Medicine and Health Sciences Commons^™

The Complex Relationship Between Tuberculosis And Hyperglycemia, Michelle Byers, Elizabeth Guy

Faculty, Staff and Students Publications

Hyperglycemia and tuberculosis are dual global pandemics. Each has a propulsive and amplifying effect on the other, and, because of this, we must consider hyperglycemia and tuberculosis together. Hyperglycemia is immunosuppressive and increases the risk of tuberculosis by threefold. It also leads to a more advanced presentation of pulmonary tuberculosis, thus increasing the likelihood of being smear positive and having cavitating lesions, and it impacts the duration and outcomes of treatment, with an increased one year mortality seen in patients with tuberculosis and diabetes. Additionally, any degree of hyperglycemia can have an impact on susceptibility to tuberculosis, and this effect …

Quality Of Newborn Care And Associated Factors: An Analysis Of The 2022 Kenya Demographic And Health Survey, John Baptist Asiimwe, Earnest Amwiine, Angella Namulema, Quraish Sserwanja, Joseph Kawuki, Mathius Amperiize, Shamim Nabidda, Imelda Namagembe, Lilian Nuwabaine

School of Nursing & Midwifery, East Africa

Kenya one of the African countries has pledged to reduce neonatal death as per the 2030 World Health Organization target. Providing high-quality newborn care is critical in minimizing neonatal mortality. This study aimed to determine the factors that influence the quality of newborn care in Kenya. Secondary data from 11,863 participants of the 2022 Kenya Demographic and Health Survey (KDHS) were analyzed. The participants were chosen using two-stage stratified sampling. The quality of newborn care was operationalized as receiving all components of newborn care after childbirth, as reported by the mother. Using SPSS (version 29), univariate and multivariable logistic regression …

The Infected Diabetic Foot: Does Negative Pressure Wound Therapy With Irrigation Reduce Bioburden And Improve Wound Healing?, Mehmet A Suludere, Matthew Malone, Michael C Siah, Arthur Tarricone, Tyler L Coye, Bijan Najafi, Lawrence A Lavery

Center on Aging Staff Publications

The aim of this study was to compare the microbial loads of patients with diabetic foot infections treated with negative pressure wound therapy (NPWT) with and without irrigation with polyhexamethylene biguanide (NPWTi-P). This is a post hoc analysis of combined data of two randomized clinical trials. We evaluated people with diabetes treated with moderate and severe diabetic foot infections that required surgery. Tissue specimens were obtained after the initial surgery and following a second planned return to the operating room after 48-72 h of NPWT or NPWTi-P, prior to the second surgery. We used quantitative polymerase chain reaction (qPCR) to …

Short-Term Effects Of Opioids During Therapeutic Hypothermia For Neonatal Encephalopathy, Tina Jumani, Priya Mishra, Tonya Robinson, Jeffrey Shenberger, Jonathan Davis, Benjamin Sweigart, Rodica Turcu

Department of Pediatrics Faculty Papers

OBJECTIVE: To examine the effects of opioids during therapeutic hypothermia (TH) on short-term outcomes in neonates with neonatal encephalopathy (NE).

METHODS: Multicenter retrospective study of neonates with moderate/severe NE from Jan. 2013-Feb 2021. Opioid exposure was classified as positive (>0.1 mg/kg) or negative (no exposure or ≤0.1 mg/kg) based on cumulative morphine milligram equivalents (MME). Negative binomial regression models were used to evaluate clinical outcomes.

RESULTS: One hundred and twenty neonates were included. Adjusted analyses indicated that opioid exposure was associated with an increase in (1) length of hospitalization, (2) hypotension/use of vasopressors, and (3) need for and longer …

Staff Education On Service Recovery For New Nurse Leaders, Cara Conley

Walden Dissertations and Doctoral Studies

The goal of this staff education project is to improve nurse leaders’ ability to execute service recovery strategies in a hospital setting. The identified practice problem was the lack of structured education for nurse leaders on service recovery, which impacts their effectiveness in managing patient dissatisfaction, potentially leading to compromised patient safety and organizational performance. The practice-focused question was: In nurse leaders, does the implementation of a service recovery education course significantly improve their knowledge on how to perform service recovery? The purpose of the project was to create and implement a structured education course for nurse leaders with 0–5 …

Evidence-Based Project To Improve Staff’S Knowledge And Attitude Toward Electroconvulsive Therapy, Nicole A. Marshall

Doctoral Dissertations and Projects

Electroconvulsive therapy (ECT) is a safe and effective treatment for depression, bipolar disorder, schizophrenia, catatonia, schizoaffective disorder, and neuroleptic malignant syndrome. Barriers to the use of ECT are misinformation and stigma among healthcare workers and limited access to the treatment. The clinical question for this scholarly project was, “In adult psychiatry and operating room staff at a multisystem hospital located in the mid-Atlantic region of the United States, improve knowledge and attitudes toward ECT?” After a brief educational PowerPoint presentation on ECT with the adult psychiatry and operating room staff, staff knowledge rose from 66% to 72% within the QuAKE …

Improving Student's Hands-On Clinical Experience Through Staff Development, Courtney Eileen Bailey

Doctoral Dissertations and Projects

Precepting students in clinical practice is a widely accepted practice for nursing education. Preceptors are nursing staff on the units working on the days the students come to practice clinical skills. These preceptors typically have minimal to no training in precepting, making them expert clinicians but novice educators. This situation can lead to a lack of knowledge of how to guide students in hands-on clinical skills during the student’s time at clinical. This lack of hands-on skills creates a poor clinical perception for the student and reduces their preparedness for practice. The purpose of this quantitative, quasi-experimental, pretest-posttest, within-subjects design …

Early Mobility And Delirium Prevention For Intensive Care Unit Patients At Kingman Regional Medical Center, Lyndsey R. Lehman Ms, Otr/L

Masters Projects

Over five million patients are admitted to the intensive care unit (ICU) annually in the United States, with 50-70% of those developing debilitating physical, cognitive, and mental health issues. Occupational therapy (OT) is a holistic profession that provides evidence-based interventions to improve ICU patients’ function and participation in daily occupations by addressing early mobility and delirium. A needs assessment performed for the Kingman Regional Medical Center (KRMC) ICU revealed a lack of knowledge about early mobility and delirium prevention among nursing staff, underutilization and limited understanding of OT services, and KRMC-specific barriers impacting patient care. This author designed and implemented …

Ar (Cag)N Microsatellite And Apex1 C444t>G (Pasp148glu) Polymorphisms As Independent Prognostic Biomarkers In Prostate Cancer: Insights From An Argentinian Cohort, Gaston Pascual, Agustina Sabater, Juan Bizzotto, Rocio Seniuk, Pablo Sanchis, Sabrina Ledesma-Bazan, Estefania Labanca, Carlos Scorticati, Osvaldo Mazza, Elba Vazquez, Ayelen Toro, Federico Prada, Geraldine Gueron, Javier Cotignola

Faculty, Staff and Student Publications

Background/objectives: Prostate cancer (PCa) is the leading malignancy and the third most common cause of cancer-related death in Argentinian men. Predicting outcomes in localized PCa remains difficult due to tumor heterogeneity. In this study, we assessed the impact of AR (CAG)n and APEX1 c.444T>G polymorphisms on biochemical relapse in Argentine patients with localized PCa.

Methods: We genotyped blood samples from 123 PCa patients for AR (CAG)n and APEX1 p.Asp148Glu (c.444T>G) polymorphisms. Associations with clinicopathological parameters and biochemical relapse-free survival (BRFS) were assessed.

Results: AR (CAG)20-23 was associated with a family history of breast/ovarian cancer (p = 0.0469). …

Tumor-Promoted Changes In Pediatric Brain Histology Can Be Distinguished From Normal Parenchyma By Desorption Electrospray Ionization Mass Spectrometry Imaging, Ana L Seidinger, Felipe L T Silva, Mayara F Euzébio, Anna C Krieger, João Meidanis, Junier M Gutierrez, Thais M S Bezerra, Luciano Queiroz, Alex A Rosini Silva, Iva L Hoffmann, Camila M M Daiggi, Helder Tedeschi, Marcos N Eberlin, Livia S Eberlin, José A Yunes, Andreia M Porcari, Izilda A Cardinalli

Faculty, Staff and Students Publications

Background: Central nervous system (CNS) tumors are the second most frequent type of neoplasm in childhood and adolescence, after leukemia. Despite the incorporation of molecular classification and improvement of protocols combining chemotherapy, surgery, and radiotherapy, CNS tumors are still the most lethal neoplasm in this age group. Mass spectrometry imaging (MSI) is a powerful tool to map the distribution of molecular species in tissue sections. Among MSI techniques, desorption electrospray ionization (DESI-MSI) has been demonstrated to enable reliable agreement with the pathological evaluation of different adult cancer types, along with an acceptable time scale for intraoperative use.

Methods: In the …

The Il-1Β Inhibitor Canakinumab In Previously Treated Lower-Risk Myelodysplastic Syndromes: A Phase 2 Clinical Trial, Juan Jose Rodriguez-Sevilla, Vera Adema, Kelly S Chien, Sanam Loghavi, Feiyang Ma, Hui Yang, Guillermo Montalban-Bravo, Xuelin Huang, Xavier Calvo, Joby Joseph, Kristy Bodden, Guillermo Garcia-Manero, Simona Colla

Faculty, Staff and Student Publications

In myelodysplastic syndromes (MDS), the IL-1β pathway is upregulated, and previous studies using mouse models of founder MDS mutations demonstrated that it enhances hematopoietic stem and progenitor cells' (HSPCs') aberrant differentiation towards the myeloid lineage at the expense of erythropoiesis. To evaluate whether targeting the IL-1β signaling pathway can rescue ineffective erythropoiesis in patients with MDS, we designed a phase 2 non-randomized single-arm clinical trial (NCT04239157) to assess the safety profile and efficacy of the IL-1β inhibitor canakinumab in previously treated lower-risk MDS patients. We enrolled 25 patients with a median age of 74 years; 60% were male, 16% had …

Worldwide Trends In Diabetes Prevalence And Treatment From 1990 To 2022: A Pooled Analysis Of 1108 Population-Representative Studies With 141 Million Participants, Ncd Risk Factor Collaboration (Ncd-Risc), Bin Zhou, Archie W. Rayner, Edward W. Gregg, Kate E. Sheffer, Rodrigo M. Carrillo-Larco, James E. Bennett, Jonathan E. Shaw, Jesus Melgarejo, Gladys Maestre

School of Medicine Publications

Background: Diabetes can be detected at the primary health-care level, and effective treatments lower the risk of complications. There are insufficient data on the coverage of treatment for diabetes and how it has changed. We estimated trends from 1990 to 2022 in diabetes prevalence and treatment for 200 countries and territories.

Methods: We used data from 1108 population-representative studies with 141 million participants aged 18 years and older with measurements of fasting glucose and glycated haemoglobin (HbA1c), and information on diabetes treatment. We defined diabetes as having a fasting plasma glucose (FPG) of 7·0 mmol/L or higher, having an HbA1c …

Effects Of High-Intensity Interval Training Combined With Resistance Training On Functional Capacity And Clinical Risk Factors In Patients With Cardiovascular Disease, Philip Matthew Wilson

Doctoral Dissertations and Projects

Moderate-intensity continuous training (MICT), resistance training (RT), MICT combined with RT, and high-intensity interval training (HIIT) have all been proven to provide clinical benefits for individuals with cardiovascular disease (CVD). However, the effects of HIIT combined with RT on functional capacity outcomes and clinical risk factors outcomes in patients with CVD are not well investigated. Therefore, the purpose of this retrospective cohort study is to investigate the synergistic effects of HIIT combined with RT on functional capacity outcomes including six-minute walk distance (6MWD), peak oxygen uptake (VO2peak), and metabolic equivalent of tasks (METs) and clinical risk factors outcomes including systolic …

The Efficacy Of Suboxone As Mat Therapy For Women: A Phenomenological Study, Sara C. Swepston

Doctoral Dissertations and Projects

The Opioid Epidemic has plagued the nation for decades, with little success in treating patients for long-term sobriety. Billions of dollars are spent annually treating patients with opiate use disorder, most popularly with the pharmaceutical drug, Suboxone. However, evidence and research are lacking to truly understand if the synthetic opiate medication works in treating women with OUD. The purpose of this phenomenological study is to know from the women who have been treated using Suboxone if the medication works. The participants are all women, aged 18-45 who used Suboxone for Medically Assisted Treatment for a minimum of 90 days. The …

The Relationship Between Moral Courage And Professional Confidence And Academic Achievement Among Precertification Radiologic Sciences Students In The United States: A Cross-Sectional Quantitative Study, Kristin M. Beinschroth

Doctoral Dissertations and Projects

Moral courage and professional confidence are traits that benefit healthcare professionals and students in practice but have yet to be explored in the radiologic science population. This study aimed to discern if relationships exist among moral courage, professional confidence, and academic achievement factors in pre-certification radiologic sciences students in the United States. This cross-sectional, nonexperimental quantitative study employed correlation and regression analyses using abridged versions of the Nurses’ Moral Courage Scale (NMCS) (Numminen et al., 2019) and the Confidence in Managing Challenging Situations Scale (CMCS) (Walsh et al., 2021). Participants exhibited high moral courage and high professional confidence, and both …

Behavioral And Neural Mechanisms Of Face-Specific Attention During Goal-Directed Visual Search, Jie Zhang, Xiaocang Zhu, Huihui Zhou, Shuo Wang

2020-Current year OA Pubs

Goal-directed visual attention is a fundamental cognitive process that enables animals to selectively focus on specific regions of the visual field while filtering out irrelevant information. However, given the domain specificity of social behaviors, it remains unclear whether attention to faces versus nonfaces recruits different neurocognitive processes. In this study, we simultaneously recorded activity from temporal and frontal nodes of the attention network while macaques performed a goal-directed visual search task. V4 and inferotemporal (IT) visual category-selective units, selected during cue presentation, discriminated fixations on targets and distractors during the search but were differentially engaged by face and house targets. …

Synthesis And Evaluation Of Photoaffinity Labeling Reagents For Identifying Binding Sites Of Sulfated Neurosteroids On Nmda And Gabaa Receptors, Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F Zorumski, Alex S Evers, Steven Mennerick, Douglas F Covey

2020-Current year OA Pubs

The endogenous neurosteroids dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate (PS) are allosteric modulators of γ-aminobutyric acid type A (GABA

Mouse Mammary Tumor Virus (Mmtv) Genomic Rna (Grna) Packaging: Selective Grna Encapsidation Is Facilitated By Long-Range Interactions (Lris) That Facilitate Specific Gag Binding, Suresha G. Prabhu

Thesis/ Dissertation Defenses

Mouse mammary tumor virus (MMTV) is a betaretrovirus that induces breast cancer and sporadically, T-cell lymphomas in mice. MMTV serves as a pertinent model for elucidating the mechanism(s) of oncogenesis and the genetics associated with the development of mammary tumors. Being a rodent retrovirus, MMTV is phylogenetically distant from human and other primate retroviruses; thus, positioning it ideally as a potential vector of choice for human gene therapy. This may circumvent safety concerns such as recombination with other related endogenous human retroviruses. In addition, MMTV is distinct from most other retroviruses, but similar to lentiviruses, in that it has the …

The Mediating Role Of Religious Coping And Psychological Inflexibility In The Relationship Between Perceived Life Stress And Depression In An Arab Muslim Sample, Mariam Kashakesh

Thesis/ Dissertation Defenses

This study examines the association between depression and perceived stress, with a particular focus on the mediating function of psychological rigidity and religious coping strategies in a sample of 18–30-year-old Arab Muslims. Online questionnaires measuring psychological flexibility, perceived stress, depression, religious coping, and demographics were filled out by participants. Higher stress levels were expected to be associated with higher levels of depression (H1), and the study postulated that both negative and positive psychological inflexibility and religious coping would mitigate this association (H2a and H2b, respectively). Significant positive relationships were found between religious coping qualities, depression, and perceived stress. A mediation …

Exploring The Interplay Of Loss, Perceived Social Support, And Prior Anxiety Levels In Predicting Death Anxiety Among Individuals Who Experienced The Loss Of A Loved One, Zeina Bassam Makki

Thesis/ Dissertation Defenses

The study explores the relationship between preceding anxiety, perceived social support, and death anxiety, particularly following bereavement. Death anxiety is a significant psychological issue, especially after the loss of a loved one, and is linked to various mental health disorders. Despite the known importance of social support in mental health, its role in mitigating death anxiety remains underexplored. This study aimed to: (1) examine how bereavement impacts death anxiety; (2) investigate whether perceived social support mediates the relationship between bereavement and death anxiety; and (3) assess the influence of preceding anxiety on death anxiety. A cross-sectional design was utilized, with …

Examining The Mediational Role Of Self-Efficacy In The Relation Between Grit And Well-Being Among Non-Traditional (Working) University Students In The U.A.E, Ektha Benny

Thesis/ Dissertation Defenses

Developments in the educational and economic sector have led to a rising number of older adults enrolling to pursue higher education. In the UAE, there is a large proportion of students who may be categorized as “non-traditional”, i.e., university students who are working, married or older in age, in comparison to “traditional” students. Yet there is a dearth of literature to understand the unique experiences of this specific student population, especially in the current context. This study adopts a strengths-based approach to investigate the experiences of university students in the UAE who are also simultaneously working. The aim of the …

The Impact Of Coordination Training On Motor Skills In Adolescent Handball Players Aged 14–15 Years: A Randomized Controlled Trial, Michał Spieszny, Wojciech Wąsacz, Zbigniew Kamys, Tadeusz Ambroży, Krzysztof Kasicki, Paweł Kapuściński, Łukasz Rydzik

Baltic Journal of Health and Physical Activity

Introduction: Motor skills are fundamental to athletic performance, particularly in sports like handball, where coordination, speed, and power are critical. This study aimed to evaluate the effects of an innovative coordination training program on the profile of motor skills of adolescent handball players compared to traditional training methods. Materials and Methods: A randomized controlled trial was conducted with 27 young handball players. Participants were divided into an experimental group (n = 15) receiving additional co-ordination training and a control group (n = 12) following standard training. The participants’ motor fitness was assessed using selected population tests from the …

Demonstrating Awareness On The Impact Of Vapes In Society, Jean Carlos Cortez-Rivera, Kianie Cruz Rosado, Andrea De Jesús Navia, Kenneth Hartú Rodríguez, Dayrimar Marchena Santiago

College of Pharmacy Student Research

Vaping, initially marketed as a smoking cessation tool, has become a public health concern due to its widespread use, particularly among youth. Despite claims of harm reduction compared to traditional cigarettes, vaping products pose significant health risks. These include respiratory issues, cardiovascular complications, and neurological impacts, largely driven by nicotine addiction and exposure to toxic substances. Vaping's appeal, fueled by extensive advertising and enticing e-liquid flavors, has led to an epidemic among adolescents, with notable social and economic consequences. Additionally, the improper disposal of vaping devices poses environmental hazards, contributing to pollution and carbon emissions. While advocates argue that vaping …

Lecture Capture, Transcripts, And Captioning In Us Colleges Of Osteopathic Medicine: Descriptive Cross-Sectional Survey, Phillip Khong, Duncan Holmes, Bahar Masoudian, Gregg C. Lund, Steve Garwood

Rowan-Virtua School of Osteopathic Medicine Departmental Research

This study describes lecture capture, transcription, and captioning services at US Colleges of Osteopathic Medicine (COMs). An anonymous online survey was sent to Deans or Directors of Curriculum at all 34 fully accredited COMs, with 21 (62%) responding. Results showed widespread lecture recording (95%), but of those, there were varied transcript and caption offerings: 7 (33%) provided both, 5 (24%) offered closed captions only, and 3 (14%) offered transcripts only. Overall, 71% offered at least one service. These findings indicate the prevalence of these lecture services at US COMs and will assist COMs in benchmarking their practices.

The Time To Treatment: A Retrospective Analysis Of The Time To All-Trans Retinoic Acid (Atra) In Patients With Suspected Acute Promyelocytic Leukemia (Apl), Grant Jirka, Md, Tara Rakiewicz, Md, Navya George, Md, Misung Yi, Phd, Lindsay Wilde, Md

Jefferson Hospital Staff Papers and Presentations

PURPOSE: Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) defined by the chromosomal translocation t(15;17), which creates fusion of the promyelocyte gene and the retinoic acid receptor alpha gene. Dysplastic promyelocytes induce aberrations in coagulation leading to hemorrhage and disseminated intravascular coagulation (DIC), which often devolves into a rapidly fatal course. Prompt administration of all-trans retinoic acid (ATRA) reverses the coagulopathy in patients with suspected APL, which ultimately decreases morbidity and mortality.

PATIENTS AND METHODS: This retrospective study examines 91 patients over a 5-year period who received ATRA for a suspected or confirmed diagnosis of APL …

Screen-Printed Wearable Sensors For Continuous Respiratory Rate Monitoring: Fabrication, Clinical Evaluation, And Point-Of-Care Potential, Ala’Aldeen Al-Halhouli, Ahmed Albagdady, Alexander Rabadi, Musab Hamdan, Jumana Abu-Khalaf, Mahmoud Abu-Abeeleh

Research outputs 2022 to 2026

In this paper, we investigated the use of screen printing for the fabrication of a non-invasive wearable sensor, aimed at achieving accurate and continuous measurement of respiratory rate. The developed sensor was clinically evaluated on 15 healthy human participants, demonstrating its potential for point-of-care testing. Wearable sensors are emerging as the future of continuous healthcare monitoring by recording crucial physiological parameters that can be processed to monitor existing health conditions and predict future ones. Having a reliable tool to monitor respiratory rate is extremely valuable for healthcare professionals since it can indicate disease progression under certain conditions like COPD (chronic …

Hypnopressure As A Non-Invasive Method For Anxiety And Pain Management In Primigravidae During Active Labor, Yeni Fitrianingsih, Hanung Prasetya, Rani Widiyanti

Folia Medica Indonesiana

Highlights:
1. This study applied hypnopressure, an innovative method that combines auditory hypnosis with acupressure on effective uterine points, namely the Hegu (LI4) and Sanyinjiao (Sp6) points.
2. This innovation offers an effective method for managing labor pain in primigravidae during the active phase of the first labor stage compared to hypnotherapy and acupressure administered separately.

Abstract
Psychological factors, such as fear and anxiety, are often responsible for prolonged labor. Anxiety affects 58% of primigravidae, while 2–4% experience pain with scores ranging from 30 to 40 out of 50. Hypnopressure is an innovative combination of hypnotherapy and acupressure applied on …

Reduction Of Postoperative Nausea And Vomiting Induced By Spinal Anesthesia: Peppermint And Lavender Aromatherapies As Complementary Therapies, Taufan Arif, Maria Diah Ciptaningtyas, Navalia Nailin Mudviyanti, Fitriana Kurniasari Solikhah

Folia Medica Indonesiana

Highlights:
1. This study provides insight into the effectiveness of peppermint and lavender aromatherapies in reducing postoperative nausea and vomiting in patients following spinal anesthesia.
2. Aromatherapies with peppermint and lavender administered three times within six hours have demonstrated potential as an easy-to-apply intervention that reduces postoperative nausea and vomiting.
3. In terms of effectiveness, however, peppermint aromatherapy exhibits a higher effectiveness in reducing nausea and vomiting compared to lavender aromatherapy.

Abstract
Nausea and vomiting are common occurrences after surgery with spinal anesthesia, potentially leading to complications and delayed recovery. Hypotension associated with spinal, epidural, and combined spinal-epidural anesthesia is …

The Differences Between Pre- And Post-Therapy Levels Of Platelet Count And Platelet Indices In Children With Immune Thrombocytopenia Purpura, Regina Rania Cahya Kusumaningrum, Mia Ratwita Andarsini, Yetti Hernaningsih, Pradana Zaky Romadhon

Folia Medica Indonesiana

Highlights:
1. This study was the first to analyze the therapeutic response in children with ITP at Dr. Soetomo General Academic Hospital, Surabaya.
2. This study analyzed the response of platelet count and indices, including MPV, PDW, P-LCR, and PCT to therapy, which provides a more comprehensive perspective on therapy response in children with ITP.
3. This study explored the effectiveness of various therapeutic approaches based on ITP categories, offering new insights into the most effective treatment options for children with ITP.

Abstract
Immune Thrombocytopenia Purpura (ITP) is an autoimmune disorder triggered by antiplatelet autoantibodies. Clinically, ITP is classified into …

Urine Periostin Level And Renal Function In Malignancy Patients Treated With High-Dose Cisplatine, Harry Yusuf, Andhika Rachman, M Bonar Marbun, Hamzah Shatri, Putri Aliya Ahadini

Folia Medica Indonesiana

Cisplatin has been used extensively as a cancer treatment. Nephrotoxicity, which is assessed by blood urea levels, blood creatinine, and estimated glomerular filtration rate (eGFR), is caused by cisplatin metabolites that build up in the kidneys. Because of these indicators' numerous flaws, optimal biological markers are required. One of the key mediators of inflammatory processes, such as kidney fibrosis and inflammation, is periostin. In cancer patients undergoing high-dose cisplatin therapy, the purpose of this study is to ascertain how urine periostin changes and how it relates to kidney function. This cross-sectional study was carried out at the National Center General …