Medicine and Health Sciences Commons^™

Effects Of A Daily, Home-Based, 5-Minute Eccentric Exercise Program On Physical Fitness, Body Composition, And Health In Sedentary Individuals, Benjamin J.C. Kirk, Georgios Mavropalias, Anthony J. Blazevich, Jodie L. Cochrane-Wilkie, Aus Molan, Kazunori Nosaka

Research outputs 2022 to 2026

Purpose: This study examined the effects of a 4-week home-based bodyweight eccentric exercise program, requiring just 5 min daily, on physical fitness, body composition, and both physical and mental health in sedentary individuals.

Methods: Twenty-two sedentary but healthy individuals (4 men, 18 women; 32–69 years) completed a two-week control period followed by a 4-week intervention. The intervention involved daily exercises consisting of 10 repetitions each of chair squats, chair reclines, wall push-ups, and heel drops, including progressions if necessary. Assessments included isometric mid-thigh pull (IMTP), handgrip (HG) strength, push-up and sit-up endurance, sit-and-reach (S&R) flexibility, 3-min step test (3ST), squat …

Fostering A Resilient Healthcare System: Supportive Practice Environment Initiatives To Support Nurse And Midwives A Scoping Review, Gemma Doleman, Dianne Bloxsome, Rong Wang, Lisa Whitehead

Research outputs 2022 to 2026

Aim: This scoping review aimed to explore supportive practice environment initiatives that support novice and expert nurses and midwives. Design: Scoping review. Methods: Studies were identified through the electronic databases Cumulative Index to Nursing and Allied Health Literature (CINAHL), MEDLINE, PsychInfo, Scopus, and Web of Science. Grey literature was searched using GreyNet, National Grey Literature Collection, ProQuest Dissertation and Theses, and Google Scholar. Results: Thirty-one papers met the criteria for inclusion and data extraction. The key concepts identified were the need for adequate staffing and resources, clear and regular communication, managerial presence and engagement in committees and relationship building, celebration …

Gestational Age–Specific Prevalence Of Preeclampsia Among Pregnant Women In Ghana: A Hospital-Based Retrospective Observational Study, Wina Ivy Ofori Boadu, Enoch Odame Anto, Akua Benewaah Asamoah, Ezekiel Ansah, Godfred Yawson Scott, Emmanuel Ekow Korsah, Joseph Frimpong, Valentine Christian Kodzo Tsatsu Tamakloe, Michael Nyantakyi, Agartha Odame Anto, Emmanuel Timmy Donkoh, Kwame Ofori Boadu, Richard Vikpebah Duneeh, Frederick Ayensu, Christian Obirikorang

Research outputs 2022 to 2026

Background: Preeclampsia is responsible for a significant rate of maternal morbidity and mortality worldwide. Gestational age as a risk factor has a significant impact on fetal outcomes in pregnancies affected by preeclampsia. However, to our knowledge, no study has identified the gestational age–specific prevalence of preeclampsia in Ghana. Thus, this study ascertained the gestational age–specific prevalence of preeclampsia as well as its associated factors. Methods: A hospital-based retrospective observational study was conducted by reviewing data collected from the maternal birth register on 619 pregnant women who delivered at the facility from 1st January 2021 to 31st December 2021. Results: Out …

Immunoglobulin G N-Glycome As A Biomarker Of Mortality Risk In Escherichia Coli Induced Sepsis, Huachen Wang, Houqiang Li, Zheng Guo, Hongda Hou, Haifeng Hou, Bing Chen

Research outputs 2022 to 2026

Background: Sepsis is a life-threatening syndrome caused by an imbalance in the inflammatory response to an infection that can lead to a high mortality rate. Escherichia coli is a common pathogen that causes sepsis. The role of immunoglobulin G N-glycome in estimating the mortality in patients with sepsis remains unknown. This study aims to reveal the clinical application of immunoglobulin G N-glycome as a potentially novel biomarker to predict mortality risk in Escherichia coli-induced sepsis. Methods: The serum immunoglobulin G N-glycome levels in 100 adult septic patient serum samples on the day of intensive care unit (ICU) admission, and 100 …

Nivolumab Plus Chemotherapy Or Ipilimumab In Gastroesophageal Cancer: Exploratory Biomarker Analyses Of A Randomized Phase 3 Trial, Kohei Shitara, Yelena Y. Janjigian, Jaffer Ajani, Markus Moehler, Jin Yao, Xuya Wang, Aparna Chhibber, Dimple Pandya, Lin Shen, Marcelo Garrido, Carlos Gallardo, Lucjan Wyrwicz, Kensei Yamaguchi, Tomasz Skoczylas, Arinilda Bragagnoli, Tianshu Liu, Michael Schenker, Patricio Yañez, Ruben Kowalyszyn, Michalis Karamouzis, Thomas Zander, Kynan Feeney, Elena Elimova, Parul Doshi, Mingshun Li, Ming Lei

Research outputs 2022 to 2026

First-line nivolumab-plus-chemotherapy demonstrated superior overall survival (OS) and progression-free survival versus chemotherapy for advanced gastroesophageal adenocarcinoma with programmed death ligand 1 combined positive score ≥ 5, meeting both primary end points of the randomized phase 3 CheckMate 649 trial. Nivolumab-plus-ipilimumab provided durable responses and higher survival rates versus chemotherapy; however, the prespecified OS significance boundary was not met. To identify biomarkers predictive of differential efficacy outcomes, post hoc exploratory analyses were performed using whole-exome sequencing and RNA sequencing. Nivolumab-based therapies demonstrated improved efficacy versus chemotherapy in hypermutated and, to a lesser degree, Epstein–Barr virus-positive tumors compared with chromosomally unstable and …

Pleural Infection: Controversies On The Therapeutic Strategies, Ken K.P. Chan, Estee P.M. Lau, Y. C. Gary Lee

Research outputs 2022 to 2026

Purpose of review Management of pleural infection remains heterogeneous worldwide. This review highlights current controversies in therapeutic strategies for pleural infection, focusing particularly on recent studies and their implications. Recent findings The introduction of intrapleural therapy combining alteplase [a tissue plasminogen activator (tPA)] and deoxyribonuclease (DNase) has revolutionized treatment practices, though the optimal delivery and dosing regimen is an area of active investigation. Variations to simplify administration protocols and/or to lower the required drug doses have been published. Most were exploratory studies, but the variations showed maintained therapeutic efficacy. Whether intrapleural alteplase/DNase or video-assisted thoracoscopic surgery (VATS) is superior is …

Practices And Perceptions In Hamstring Training For Injury Risk Mitigation: A Survey-Based Mixed-Methods Analysis, Steven Ross, Nicholas J. Ripley, John J. Mcmahon, Paul Comfort

Research outputs 2022 to 2026

In this study, the practices and perceptions of sport and exercise practitioners regarding hamstring training for injury risk mitigation were investigated. Hamstring strain injuries (HSIs) remain a prevalent issue across sports, despite extensive research. An anonymous survey was conducted to assess how practitioners integrate evidence-based strategies, such as the Nordic hamstring exercise (NHE) and high-speed running (HSR), into their training programmes. The survey included both fixed-response and open-ended questions, enabling a mixed-methods analysis of training approaches. A total of 47 practitioners responded, revealing that most incorporate the NHE and HSR into both in-season and off-season training. However, there were notable …

Prevalence And Profile Of New Zealand Osteopaths Treating People Experiencing Headaches And Migraines, Ana Paula Antunes Ferreira, Brett Vaughan, Jerry Draper-Rodi, Lee Muddle, Loïc Treffel, Cindy Mcintyre, Michael Fleischmann, Francesco Cerritelli, Kesava Kovanur Sampath, Amie Steel

Research outputs 2022 to 2026

To describe the prevalence and profile of NZ osteopaths treating people experiencing headaches and migraines. This study is the first to describe this practice. Manual and manipulative therapy interventions are commonly sought by individuals experiencing headaches or migraines. Evidence supports the use of manual therapy as part of the management of headache and migraine disorders. Osteopaths are health professionals who provide care for individuals experiencing headaches and migraines. However, there is a lack of data concerning the profile of osteopaths treating these conditions, in addition to their diagnostic and management strategies. The Osteopathy Research Connect-New Zealand (ORC-NZ), a practice-based research …

Sleep In Residential Aged Care: A Secondary Qualitative Analysis Of Data From The Australian Royal Commission Into Aged Care Quality And Safety, Aisling Smyth, Patricia Cain, Sabine Pangerl, Christopher Gordon, Kasia Bail, Davina Porock

Research outputs 2022 to 2026

Background:

Sleep is a crucial healing and restorative component of older person care but is often negatively impacted through the effects of institutionalization in residential aged care (RAC). Currently, information about how sleep occurs is limited.

Methods:

Through the lens of person-centered care, this study examined submissions to the Australian Royal Commission into Aged Care Quality and Safety. The Commission was established in 2018 with the aim of protecting and improving the safety, quality of life, and well-being of people receiving aged care. The commission received 10 000+ submissions from a range of stakeholders, including consumers, family members, expert witnesses, …

Sports Metaresearch: An Emerging Discipline Of Sport Science And Medicine, John Warmenhoven, Paolo Menaspà, David N. Borg, Simine Vazire, Nicole White, Kristin Sainani, Sophia Nimphius, Aaron J. Coutts, Franco M. Impellizzeri

Research outputs 2022 to 2026

Inadequacies in the conduct and quality of research are well established across many research domains, including sport science and medicine. Metaresearch—the practice of performing research on research—is presented as a practical vehicle for improving research quality through evaluating the research processes. This article introduces the concept of metaresearch to sport as a new sub-field of sport science. The broad types of metaresearch are introduced, with a mapping of current sports metaresearch activity across these areas. Interdisciplinary centres aimed at improving scientific quality across other fields are also introduced to sport, and specific considerations for beginning metaresearch are provided for sport. …

Survival After Cessation Of Immunotherapies In Melanoma: A Systematic Review And Meta-Analysis, Kristine E. Mayer, Lydia Warburton, Anne Zaremba, Sarah Preis, Yannick Foerster, Tilo Biedermann, Oana Diana Persa

Research outputs 2022 to 2026

Background: Immune-checkpoint inhibitor (ICI) therapy elicits durable responses in a subset of patients with advanced melanoma. However, the appropriate timing for treatment cessation remains an unresolved issue. Moreover, some patients are required to discontinue therapy due to the occurrence of severe adverse events. Upon treatment cessation, a subset of patients maintains a durable response, while some patients relapse and require rechallenge with ICI. Criteria for a safe stop of ICI have not been established. Objectives: The aim of this systematic review and meta-analysis was to evaluate the durability of response in melanoma patients who discontinued ICI therapy. Furthermore, the outcome …

Travel Therapy: Simple Exercise Interventions For Osteoporosis Patients, Jun Wen, Fangli Hu, Yuan Chai

Research outputs 2022 to 2026

No abstract provided.

Understanding The Lived Experiences Of Individuals With Functional Neurological Disorders (Fnd) In Australia, Omid Rezaei, Mandy Stanley

Research outputs 2022 to 2026

Purpose: This study aims to explore the lived experiences of individuals with Functional Neurological Disorder (FND) in Australia, focusing on the challenges they face in daily life, healthcare interactions, and service access. Materials and methods: A qualitative approach was employed, involving semi-structured interviews with 11 participants diagnosed with FND. Data were analysed thematically to identify key issues impacting their experiences. Results: Five key themes emerged: (1) disruptions in daily life due to symptoms, (2) a prolonged and frustrating diagnostic journey, (3) difficulties accessing healthcare services in regional areas, (4) societal misconceptions and stigma surrounding FND, and (5) financial strain linked …

Why We Must Stop Assuming And Estimating Menstrual Cycle Phases In Laboratory And Field-Based Sport Related Research, Kirsty Jayne Elliott-Sale, Marco Altini, Patricia Doyle-Baker, Eva Ferrer, Tessa Rose Flood, Rachel Harris, Franco Milko Impellizzeri, Xanne Janse De Jonge, Katrine Okholm Kryger, Gary Lewin, Constance M. Lebrun, Alan Mccall, Sophia Nimphius, Stuart M. Phillips, Paul A. Swinton, Madison Taylor, Evert Verhagen, Richard James Burden

Research outputs 2022 to 2026

The increased growth, popularity, and media interest in women’s sport has led to calls for greater prioritisation of female-specific research and innovation. In response, science and medicine researchers have increased the volume of sport-related studies investigating female-specific matters, such as the menstrual cycle. Whilst the accelerated rate of published studies with female participants is welcome, the emerging trend of using assumed or estimated menstrual cycle phases to characterise ovarian hormone profiles is a significant concern. Replacing direct measurements of key characteristics of the menstrual cycle (e.g. the surge in luteinising hormone prior to ovulation via urine detection and sufficient luteal …

A Turning Point In Cardiac Remodelling In Obesity: Obesity, Mariella R. Huaman, Carlos J. Toro-Huamanchumo

Research outputs 2022 to 2026

Cardiac remodelling in obesity has received growing attention in the past two decades, particularly as the prevalence of obesity continues to rise globally. In 2013, Aurigemma and colleagues published a seminal study that provided crucial insights into the structural changes in the heart associated with obesity. This study summarized advances in understanding how the disproportionate growth of adipose tissue affects cardiac function, and challenged and reshaped previously established paradigms. Before the publication of this report, the standard paradigm held that obesity-induced haemodynamic stress primarily drove eccentric left ventricular hypertrophy. However, this study instead demonstrated that in individuals with obesity, concentric …

Effect Of 6-Week Single Leg Countermovement Jump Training On Force Time Metrics In Elite Female Youth Footballers, Jack T. Fahey, Paul Comfort, Paul Jones, Nicholas, J. Ripley

Research outputs 2022 to 2026

Female football participation has grown exponentially. Unfortunately, females exhibit greater injury risk than male athletes, and experience increased mechanical stress during adolescence. Force plates provide accurate and reliable force-time characteristics enabling profiling of injury risk and benchmarking using a variety of jump and isometric tasks. The purpose of this study was to determine whether test-retest reliability and force-time characteristics of SLCMJ, bilateral countermovement jump (CMJ), countermovement rebound jump (CMJ-R) and isometric mid-thigh pull (IMTP) change with six weeks of SLCMJ training. Twenty-eight elite youth female footballers (13.7 ± 1.1 years, 53.27 ± 8.82 kg, 162.20 ± 5.37 cm) completed six …

Igg N-Glycosylation Contributes To Different Severities Of Insulin Resistance: Implications For 3p Medical Approaches, Xiaohong Chen, Lois Balmer, Kun Lin, Weijie Cao, Ziyu Huang, Xiang Chen, Manshu Song, Yongsong Chen

Research outputs 2022 to 2026

Background: Reliable biomarkers capturing immunometabolic processes in insulin resistance (IR) remain limited. IgG N-glycosylation modulates immune responses and reflects metabolic disorders, yet its role in IR remains unclear. This study investigated its potential for early detection, risk stratification, and targeted prevention within the framework of predictive, preventive, and personalised medicine (PPPM/3PM). Methods: A total of 313 participants were categorized into three groups based on the homeostatic model assessment for insulin resistance (HOMA-IR): insulin-sensitive (HOMA-IR < 2.69 without diabetes, n = 75), mild IR (HOMA-IR ≥ 2.69 without diabetes, n = 155), and severe IR (HOMA-IR ≥ 2.69 with type 2 diabetes, n = 83). Canonical correlation analysis was conducted to explore the overall relationship between IgG N-glycosylation and IR-related inflammation, indicated by tumour necrosis factor-α, interleukin- 6, C-reactive protein, and adiponectin. Mediation analysis was performed to evaluate the effect of IgG N-glycans on IR. Ordinal logistic regression was used to assess the association between IgG N-glycans and IR severity, with discriminative power evaluated using receiver operating characteristic curves. Results: Pro-inflammatory IgG N-glycoforms, characterized by reduced sialylation and galactosylation, along with increased bisecting N-acetylglucosamine, were observed as IR severity increased. IgG N-glycosylation significantly correlated with inflammatory markers in the insulin-sensitive (r = 0.599, p < 0.05), mild (r = 0.461, p < 0.05), and severe (r = 0.666, p < 0.01) IR groups. IgG N-glycosylation significantly influenced IR (β = 0.406) partially via modulation of inflammation. Increased glycoforms FA2[6]G1 (OR: 0.86, 95% CI: 0.78–0.96) and A2G2S2 (OR: 0.88, 95% CI: 0.82–0.94) were associated with a lower IR risk, with respective area under the curves (AUCs) of 0.752, 0.683, and 0.764 for the insulin sensitive, mild, and severe IR groups. Conclusions: IgG N-glycosylation contributes to IR by modulating inflammatory responses. Glycoforms FA2[6]G1 and A2G2S2 emerge as protective biomarkers, offering potential for predicting and preventing IR through primary prevention strategies within the PPPM framework.

Implementation Of A Coach-Supported Mhealth Intervention For Dementia Prevention In China: A Qualitative Study Among Chinese Participants And Coaches In The Prodemos Trial, Jinxia Zhang, Marieke P. Hoevenaar-Blom, Xuening Jian, Haifeng Hou, Siqi Ge, Carol Brayne, Esmé Eggink, Melanie Hafdi, Mingyue He, Guohua Wang, Wenzhi Wang, Wei Zhang, Yueyi Yu, Yixuan Niu, Jihui Lyu, Libin Song, Wei Wang, Youxin Wang, Eric P. Moll Van Charante, Manshu Song

Research outputs 2022 to 2026

Background Modifiable risk factors have been linked to 45% of dementia cases. Mobile health (mHealth) interventions targeting lifestyle-related risk factors with remote coaching have the potential to reach underserved high-risk populations globally. To date, little is known about the implementation of such interventions in China. Methods Fifty semi-structured interviews were conducted with 14 participants and 11 health coaches involved in the PRODEMOS trial. This trial investigated whether a coach-supported mHealth application intervention can reduce dementia risk in people aged 55–75 years with multiple risk factors. Interviews were conducted three months and 12–18 months into the intervention, focusing on implementation outcomes …

Investigating Protective And Risk Factors And Predictive Insights For Aboriginal Perinatal Mental Health: Explainable Artificial Intelligence Approach, Guanjin Wang, Hachem Bennamoun, Wai Hang Kwok, Jenny Paola Ortega Quimbayo, Bridgette Kelly, Trish Ratajczak, Rhonda Marriott, Roz Walker, Jayne Kotz

Research outputs 2022 to 2026

Background: Perinatal depression and anxiety significantly impact maternal and infant health, potentially leading to severe outcomes like preterm birth and suicide. Aboriginal women, despite their resilience, face elevated risks due to the long-term effects of colonization and cultural disruption. The Baby Coming You Ready (BCYR) model of care, centered on a digitized, holistic, strengths-based assessment, was co-designed to address these challenges. The successful BCYR pilot demonstrated its ability to replace traditional risk-based screens. However, some health professionals still overrely on psychological risk scores, often overlooking the contextual circumstances of Aboriginal mothers, their cultural strengths, and mitigating protective factors. This highlights …

Nutritional Strategies To Improve Post-Exercise Recovery And Subsequent Exercise Performance: A Narrative Review, Alireza Naderi, Jeffrey A. Rothschild, Heitor O. Santos, Amin Hamidvand, Majid S. Koozehchian, Abdolrahman Ghazzagh, Erfan Berjisian, Tim Podlogar

Research outputs 2022 to 2026

Post-exercise recovery strategies influence the body’s ability to restore physiological homeostasis, replenish energy stores, repair muscle damage, and promote desired adaptations, which improve exercise performance. This narrative review examines the impact of nutritional strategies commonly used for enhancing recovery and subsequent exercise performance, particularly when athletes face short recovery periods. Carbohydrate ingestion is essential for glycogen replenishment, especially within the initial hours post-exercise, with its impact dependent on the types, timing, and amount. Protein is essential for accelerating muscle recovery and achieving a positive nitrogen balance, depending on the type and dosage. The co-ingestion of carbohydrates with proteins or fats …

Quality Cancer Survivorship Care: A Modified Delphi Study To Define Nurse Capabilities, Gemma Mcerlean, Heidi Hui, Fiona Crawford-Williams, Nicolas H. Hart, Meinir Krishnasamy, Bogda Koczwara, Thomas Walwyn, Mahesh Iddawela, Rebecca Mcintosh, Raymond J. Chan, Michael Jefford

Research outputs 2022 to 2026

Purpose: To establish capabilities required by nurses to deliver quality cancer survivorship care in Australia. Methods: A two-round online modified Delphi involving Australian cancer nurses. Initial domains and capability statements were based on the Quality of Cancer Survivorship Care Framework and supplemented by national and international nursing frameworks. In Round 1 (R1), experts categorised the applicability of 53 capabilities for cancer nurses, across eight domains, in relation to Australian National Professional Development Framework for Cancer Nursing (EdCaN) groups: ‘All’, ‘Many’, ‘Some’, and ‘Few’ nurses, or not relevant. In Round 2 (R2), experts rated agreement with capabilities allocated to the nurse …

Train Less And Still Similarly Improve? Maturational Growth Is More Influential Than Training Engagement On Performance Indices Development In Volleyball, Stephen Cobley, Marie Javet, Shaun Abbott, Caitlin Fox-Harding, Stephen Bested, Daniel Hackett, Michael Romann

Research outputs 2022 to 2026

Identifying factors which more or less account for performance improvement during developmental stages is essential for sports science knowledge and coaching practice. Accordingly, this study examined the longitudinal, changing, influences of Volleyball-specific Training Engagement (VTE) and Maturity Status on physical test performance development. Participants were N = 139 Swiss female competitive volleyball players, aged 10–14 years at baseline (M = 12.93, SD = 1.15 years). Annually for 3 years, participants completed the 9-3-6-3-9 Agility Sprint; Standing Long Jump [SLJ] and Jump & Reach test. Linear Mixed Models (LMMs) examined longitudinal independent and interactive relationships between VTE (hours/week) and Maturity Status …

When Nurses Worry: A Concept Analysis Of Intuition In Clinical Deterioration, Amy Louise Byrne, Deb Massey, Tracy Flenady, Justine Connor, Wei Ling Chua, Danielle Le Lagadec

Research outputs 2022 to 2026

Background: Nurse worry is a criterion often included in early warning systems tools and used to escalate care when other clinical markers do not indicate deterioration. What it means to worry, however, is not always clear. Aims: To generate a concept analysis of nurse worry in relation to clinical deterioration. Design: Rodgers's evolutionary method was used. Method: A review was first conducted in April 2024, searching the Cumulative Index for Nursing and Allied Health Literature, Pubmed, EmCare, and Embase databases. A total of 22 articles were subjected to analysis of the antecedents, attributes, and consequences of nurse worry in the …

Assessment Of Multilingual Children By Western Australian Speech-Language Pathologists: A Survey Of Practices, Barriers And Facilitators, Emily Frances Hunt, Charn Nang, Suzanne Jacqueline Meldrum, Elizabeth Armstrong

Research outputs 2022 to 2026

Purpose: In the past decade, diagnostic criteria for developmental language disorder, guidelines for assessment of multilingual children, and reviews of the diagnostic utility of dynamic assessment have been published. It is unknown how Australian speech-language pathologists currently assess multilingual children or how local factors influence assessment. Method: A mixed-method anonymous online survey of Western Australian speech-language pathologists explored the frequency and perceived usefulness of assessment practices recommended for multilingual children, elements of dynamic assessment used, and the utility of specific client factors for diagnosis. Confidence ratings and descriptions of barriers and facilitators that affect assessment of multilingual children were also …

Clinical Impact Of Sub-Clonal Ras/Braf Alterations In Liquid Biopsies From Patients With Advanced Or Metastatic Crc, Peter Gibbs, Khalid Abubaker, Danyi Wang, Zheng Feng, Jawad Hamad, Jiemin Liao, Christopher Stroh, Soetkin Vlassak, Kathrin Heinrich, Adnan Khattak, Juergen Scheuenpflug

Research outputs 2022 to 2026

Introduction: Colorectal cancer (CRC), a global health concern, requires effective treatments. Anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibodies are used for RAS wild-type and BRAFV600 mutation-negative metastatic CRC (mCRC) but are not indicated for RAS mutant CRC. Evidence suggests CRC patients with sub-clonal RAS/BRAF mutations in tumor tissue may benefit from anti-EGFRs. We assessed the outcomes of patients with sub-clonal RAS/BRAF mutated advanced/mCRC receiving anti-EGFRs using liquid-based GuardantINFORM real-world clinical-genomic analysis. Patients and Methods: GuardantINFORM analyzed US patients with advanced CRC with BRAFV600/KRAS/NRAS mutations who received anti-EGFR therapies within 90 days after a Guardant360 test. Primary endpoints were time-to-next treatment …

Decolonising Outcome Measurement: A Systematic Review Of Health And Wellbeing Measures For Māori, Margaret Sandham, Maree Roche, Melissa Carey, Richard J. Siegert, Rebecca J. Jarden

Research outputs 2022 to 2026

The objective of the study is to conduct a systematic review and methodological quality appraisal on studies reporting the development of health and wellbeing outcome measures for Māori (Indigenous people of New Zealand), identify common features and processes, and critically appraise the measures using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN). Key databases were searched using key terms in May 2022 without date limiters. English or Māori language publications were included if they reported Māori health and wellbeing outcome measure development. Studies were then appraised using the COSMIN. Seven publications developed outcome measures and seven reported …

Feasibility Of Conducting A Randomized Controlled Trial To Explore The Muscular Influence Of Post-Operative Intravenous Iron Treatment For Anaemia After Major Abdominal Surgery, Beth Maclean, Robert U. Newton, Jayne Lim, Toby Richards

Research outputs 2022 to 2026

Background and Objectives: Iron deficiency anaemia is common in patients recovering from major surgery and is associated with poorer post-operative outcomes. We designed a randomized controlled trial treating post-operative anaemia with iron therapy to observe the influence on post-operative recovery. Materials and Methods: Anaemic patients (haemoglobin [Hb] < 120 g/L for women, Hb < 130 g/L for men) recovering from major abdominal surgery at Fiona Stanley Hospital were recruited. Patients were double-blind randomized 1:1 to ferric carboxymaltose (FCM) or saline administered 4 weeks post-discharge and included in a 12-week exercise programme. Iron indices, quality of life (QoL) questionnaires and muscle function tests were conducted at 4 weeks (baseline), 8-, 12- and 16-weeks post-discharge. This pilot study primarily aimed to assess the feasibility of recruiting 20 patients per intervention arm. Trial registration: ACTRN12622001447741. Results: Of 205 eligible patients screened between 5 May 2023 and 31 August 2023, only four patients were recruited, of which one completed the study. After randomization to FCM, results obtained from the sole participant that completed the trial suggested a trend towards improvement in QoL outcomes, Hb and muscle function. Conclusion: Recruitment to a randomized controlled trial exploring the influence of iron therapy on muscle function after major abdominal surgery was not feasible.

Focus On Frailty: Co-Designing Digital Frailty Education With Healthcare Students, Kristiana Ludlow, Sarah Martin, Benignus Logan, Ruth E. Hubbard, Nicola Warren, Olivia Gallagher, Bonnie K. Kwok, Rosemary Saunders

Research outputs 2022 to 2026

Introduction: Frailty is prevalent in hospitals and is associated with adverse events and poor health outcomes. In Australia, there is a need for co-designed, multidisciplinary, and contextually relevant frailty education to improve healthcare students’ understanding and knowledge of frailty within the hospital setting. Objective: This study aimed to i) explore healthcare students’ understanding of frailty and their experiences with patients who are frail, and ii) seek healthcare students’ design ideas for the content of a new digital frailty education course.

Methods: Participants were university students enrolled in a health-related degree. Online focus groups and interviews were conducted between August and …

Individual Differences Provide A Nuanced Understanding Of The Contributions Of Age, Experience, And Level Played To Superior Perceptual-Cognitive-Motor Skill, Khaya Morris-Binelli, Minerva A. Westbrook, Benjamin Piggott, Sean Müller, Paola Chivers

Research outputs 2022 to 2026

Theories of expertise either predict superior performance is due to monotonic and progressive exposure to a domain task or due to non-linear exposure to a domain. The aim of this study was to explore the predictions of these theories by use of an individual differences approach to investigate how age, experience, and level played within a sample of athletes with high expertise contributes to superior perceptual-cognitive-motor skill. Twenty-seven players sampled from junior rugby union high-performance pathways and professional rugby union teams in Australia completed an in-situ perceptual-cognitive-motor test involving four attackers and three defenders. Participants were presented with scenarios representative …

Training Load Influences Gut Microbiome Of Highly Trained Rowing Athletes, B. Charlesson, J. Jones, C. Abbiss, P. Peeling, S. Watts, C. T. Christophersen

Research outputs 2022 to 2026

Background: Despite the importance of the gut microbiome on physical performance and health, little is known on the impact of training on an athlete’s gut health. Objective: This study investigates the effect of training load on markers of gut health. Methods: Whole stool (24 h) samples were collected from 23 highly trained rowers (mean ± SD; age 19.2 ± 1.1 y; weight 80.1 ± 11.4 kg; height 1.83 ± 0.09 m) following periods of high (HT) and low training load (LT). The microbiome and short-chain fatty acid concentrations were characterized from the whole stool samples. Three-day weighted food records were …