Medicine and Health Sciences Commons^™

Why A Healthy Diet Is Important For Women's Health, Halley Doster

Theses and Dissertations

Nutrition plays a critical role in women’s reproductive health, yet many women face barriers to maintaining a balanced diet. This study aimed to examine the relationship between nutritional intake and reproductive health outcomes among women of reproductive age, as well as to assess their knowledge and challenges related to healthy eating. Using a cross-sectional survey design, data were collected from 50 women at a community health center and analyzed using SPSS to generate descriptive statistics and explore patterns through chi-square and regression analyses. Findings revealed that most participants had moderate to low fruit and vegetable intake, and fewer than half …

Attacking Diabetes One Day At A Time, Kyla Duncan

Theses and Dissertations

The "Attacking Diabetes One Day at a Time" initiative targets the growing concern of public health, type 2 diabetes, among under-reserved communities. This comprehensive care program emphasizes the importance of prevention through education, improving lifestyles, and access to care. Based on insights from the Self-Care Management Theory, this initiative seeks to provide individuals with sound, culturally tailored strategies that reduce disease risk and help them manage healthy lifestyles. Major components include educational workshops, and resource navigation. The success of this program, from community engagement through evaluation on a phased implementation plan, is guaranteed. The expected outcomes of this work will …

Analysis Of The Utilization Of Vegfinhibitors In Rhode Island And In Medicare Part B Nationally, Kevin Izzio

Open Access Master's Theses

Statement of the Problem: Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are leading causes of blindness and low vision in the United States. In 2019, approximately 19.8 million Americans were living with AMD, which is classified into dry (non-neovascular) and wet (neovascular) forms, with the latter being more severe. DR, a complication of diabetes, affected an estimated 9.6 million Americans in 2021, with progression leading to proliferative DR (PDR) and diabetic macular edema (DME), both of which can cause vision loss. Vascular endothelial growth factor (VEGF) inhibitors are the standard treatment for these retinal diseases, targeting abnormal angiogenesis …

Associations Between Dietary Sodium And Potassium Intakes, Urinary Sodium And Potassium Excretion And Blood Pressure Among Adult Females In Oromia Region, Ethiopia, Fred Baffour Addo

Open Access Master's Theses

Introduction: Accurate assessment of sodium (Na) and potassium (K) intake is essential for population level monitoring of salt intake as part of global strategies to reduce salt consumption to control the increasing prevalence of high blood pressure (BP). Thus, a simple, cost-effective, and low-burden method is particularly valuable in resource-limited settings for population level monitoring of Na and K intake. This study aimed to compare the reliability of various methods of Na and K intake assessment, and their associations with blood pressure measurements.

Methods: This secondary analysis was based on a cross-sectional study of 100 non-pregnant women of …

Maternal Lipidomics For The Accurate Prediction Of Fetal Cyanotic Congenital Heart Defects, Onur Turkoglu, Nadia Ashrafi, Ali Yilmaz, Romana Ashrafi Mimi, Abdullah Khan, Perry Friedman, Ciara Talbot, Stewart Graham, Ray Bahado-Singh

Conference Presentation Abstracts

Objective: Late diagnosis of cyanotic congenital heart defects (CCHD) significantly increases newborn morbidity and mortality. However, a significant percentage of CCHD cases remain undetected prenatally. Our objectives were therefore to evaluate the accuracy of maternal serum lipidomic markers for the prenatal detection of CCHD and also to elucidate the pathogenesis of these disorders. Study Design: This prospective case-control study included 40 cases of CHD (22 cyanotic, 18 acyanotic) and 39 unaffected controls. Maternal serum samples were profiled via a combination of Ultra-High-Performance Liquid Chromatography coupled with Mass Spectrometry and Nuclear Magnetic Resonance. The mean of each lipid specie was compared …

Evaluation And Treatment Of Baseball Pitchers: There’S More To Assess Than The Arm, Matthew L. Gauthier, Casey A. Unverzagt, George J. Davies

Physical Therapy Faculty Publications

Injuries are commonplace in the overhead athlete, with many occurring to the shoulder and elbow. The increasing prevalence of injuries to the shoulder and elbow has been discussed at length in recent years, with increased research focus being placed on arm care for rehabilitation and prevention strategies. Even though the pitching motion is well-established as a whole-body kinetic chain movement, most attention in rehabilitation and prevention efforts is often placed on the upper extremity. The purpose of this clinical commentary is to highlight the impact the lower extremity and trunk have on the upper extremity during the throwing motion, better …

Depletion Of Adipose Stroma-Like Cancer-Associated Fibroblasts Potentiates Pancreatic Cancer Immunotherapy, Joseph Rupert, Alexes Daquinag, Yongmei Yu, Yulin Dai, Zhongming Zhao, Mikhail G Kolonin

Faculty, Staff and Student Publications

This study shows that populations of CAFs have distinct effects on pancreatic cancer progression and shows that depletion of CAFs expressing adipose markers potentiates tumor/metastasis suppression effects of immune checkpoint blockade.

Tagraxofusp Maintenance Post-Hematopoietic Stem Cell Transplantation Provides Long-Term Survival And Manageable Safety For A Patient With Blastic Plasmacytoid Dendritic Cell Neoplasm, Qaiser Bashir, Marina Konopleva, Glorette Abueg, Jeremy Ramdial, Chitra Hosing, Samer A Srour, Amin Alousi, Uday R Popat, Yago Nieto, Gheath Alatrash, Richard E Champlin, Elizabeth J Shpall, Muzaffar Qazilbash, Naveen Pemmaraju

Faculty, Staff and Student Publications

Presented here is the case of a 68-year-old woman with blastic plasmacytoid dendritic cell neoplasm (BPDCN) treated with tagraxofusp (TAG) maintenance therapy post-allogeneic hematopoietic stem cell transplantation (allo-HCT). Prior to allo-HCT, the patient was treated with hydroxyurea and mini-CVD (cyclophosphamide, vincristine, and dexamethasone alternating with methotrexate (Methotrexate) and cytarabine) + venetoclax + TAG for 5 cycles, which induced morphologic complete remission with minimal residual disease. After allo-HCT, the patient had persistent cytogenic abnormalities 45,XX,der(7)add(7)(p13)del(7)(q11.2q22)add(7)(q32),add(12)(p13),-15,del(16)(q23),-17,+22,+2mar[1]/46,XX[19], and was then treated with TAG maintenance therapy at 9 mg/kg on a 28-day cycle for 16 cycles. At mid-treatment (cycle 6 of 16 cycles of …

Co-Morbid Indomethacin-Responsive Headaches In A Woman In Her Late 60s With Paroxysmal Hemicrania And Hypnic Headache: A Case Report, Ashlyn Brown, Randolph W Evans, Claudia Carrizo, Mark Burish

Faculty, Staff and Student Publications

Paroxysmal hemicrania (PH) and hypnic headache (HH) are rare indomethacin-responsive headache syndromes. This case report details the new onset of both disorders in a woman in her late 60s. One headache type presented as severe pain centered on the right eyebrow, lasting 30 minutes, occurring more than 8 times daily, and associated with ipsilateral lacrimation and rhinorrhea. The second type was a right frontal severe pain, with onset at 4 a.m., occurring only during sleep, lasting 30 minutes, and with no associated factors. The patient's response to indomethacin for both headache types was confirmed through an unblinded ABAB study design: …

A Bayesian Deep Segmentation Framework For Glioblastoma Tumor Segmentation Using Follow-Up Mris, Tanjida Kabir, Kang-Lin Hsieh, Luis Nunez, Yu-Chun Hsu, Juan C Rodriguez Quintero, Octavio Arevalo, Kangyi Zhao, Jay-Jiguang Zhu, Roy F Riascos, Mahboubeh Madadi, Xiaoqian Jiang, Shayan Shams

Faculty, Staff and Student Publications

Background: Glioblastoma (GBM) is the most common malignant brain tumor with an abysmal prognosis. Since complete tumor cell removal is impossible due to the infiltrative nature of GBM, accurate measurement is paramount for GBM assessment. Preoperative magnetic resonance images (MRIs) are crucial for initial diagnosis and surgical planning, while follow-up MRIs are vital for evaluating treatment response. The structural changes in the brain caused by surgical and therapeutic measures create significant differences between preoperative and follow-up MRIs. In clinical research, advanced deep learning models trained on preoperative MRIs are often applied to assess follow-up scans, but their effectiveness in this …

Examining Educational And Career Transition Points Among A Diverse, Virtual Mentoring Network, Erika L Thompson, Toufeeq Ahmed Syed, Zainab Latif, Katie Stinson, Damaris Javier, Gabrielle Saleh, Jamboor K Vishwanatha

Faculty, Staff and Student Publications

Given the differences in trajectory for under-represented minorities in biomedical careers, we sought to explore how a virtual mentoring program, the National Research Mentoring Network (NRMN), and its platform (MyNRMN), may facilitate transitions in the science, technology, engineering, mathematics, and medicine (STEMM) pipeline. The purpose of this study was to describe how the size of an MyNRMN member’s mentoring network and level of engagement correlate with academic and career transitions. We examined MyNRMN platform user data from March 2020 to May 2021 (n = 2993). Logistic regression estimated the odds of a career or academic transition related to NRMN …

Key Considerations For Combination Therapy In Alzheimer’S Clinical Trials: Perspectives From An Expert Advisory Board Convened By The Alzheimer’S Drug Discovery Foundation, Jeffrey Cummings, Michael Gold, Mark Mintun, Michael Irizarry, Andrew Von Eschenbach, Suzanne Hendrix, Donald Berry, Cristina Sampaio, Kaycee Sink, Jaren Landen, Miia Kivipelto, Michael Grundman, Steven E Arnold, Allan Green, Katherine Partrick, Laura Nisenbaum, Aaron Burstein, Howard Fillit

Faculty, Staff and Student Publications

There is growing consensus in the Alzheimer's community that combination therapy will be needed to maximize therapeutic benefits through the course of the disease. However, combination therapy raises complex questions and decisions for study sponsors, from preclinical research through clinical trial design to regulatory, statistical, and operational considerations. In January 2024, the Alzheimer's Drug Discovery Foundation convened an expert advisory board to discuss the key considerations in each of these areas. Experts agreed on the need to prioritize a combination therapy approach that encompasses a wide range of targets associated with aging and the underlying biology of Alzheimer's disease. Progress …

Sift Feature-Based Relative Altitude Estimation Enhanced With Siamese Network, Shirin Nasr-Esfahani, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

In GPS-denied environments or when GPS signals are unreliable or unavailable, alternative methods of accurate localization with coordinate generation become critical. To address localization, the scale-invariant feature transform (SIFT) algorithm, along with its numerous adaptations, is extensively utilized in computer vision and remote sensing for matching image features to identify objects and perform localization. This article presents a novel approach for estimating the relative altitude of unmanned aerial vehicles (UAVs) using SIFT features' scale (size), omitting the need for additional data like camera intrinsic parameters, as well as extensive image datasets are also required for training. Furthermore, the approach enhances …

Safe Optimal Control Of Quadrotor Formations Using Multilayer Neural Networks And Continual Learning, Ehsan Soleimani, Irfan Ahmad Ganie, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This article presents an integral reinforcement learning-based optimal formation tracking scheme for multiple quadrotors unmanned aerial vehicles (QUAVs) experiencing nonlinear coupled dynamics and subject to constraints. We use multilayer neural networks (MNN) within an actor-critic framework where the MNN weights are tuned using singular value decomposition (SVD) of the activation function gradient to approximate optimal control policy via backstepping. Additionally, barrier Lyapunov functions (BLF) are introduced to ensure set invariance, thereby maintaining the quadrotors within a defined safety space due to constraints. A novel weight update law for each layer is derived using the HJB approximation error and control input …

Explainable And Safety Aware Deep Reinforcement Learning-Based Control Of Nonlinear Discrete-Time Systems Using Neural Network Gradient Decomposition, Behzad Farzanegan, S. Jagannathan

Electrical and Computer Engineering Faculty Research & Creative Works

This paper presents an explainable deep-reinforcement learning (DRL)-based safety-aware optimal adaptive tracking (SOAT) scheme for a class of nonlinear discrete-time (DT) affine systems subject to state inequality constraints. The DRL-based SOAT utilizes a multilayer neural network (MNN)-based actor-critic to estimate the cost function and optimal policy while the MNN update laws are tuned both using the singular value decomposition (SVD) of activation function gradient in order to mitigate the vanishing gradient issue and safety-aware Bellman error at each layer. An approximate safety-aware optimal policy is developed using Karush–Kuhn–Tucker (KKT) conditions by incorporating the higher-order control barrier function (HOCBF) into the …

Effect Of Non-Complicated Cataract Extraction With Phacoemulsification On Central Macular Thickness (Cmt) And Ganglion Cell Complex (Gcc) In Non-Diabetic Patients At Sohag Teaching Hospital, Mohammed Shikhoun Ahmed, Mariam Kamal

Journal of Medicine in Scientific Research

Background: Cataracts are widely acknowledged as the primary cause of blindness on a global scale. Cataract surgery, particularly phacoemulsification, is the most effective and the only approved intervention for cataracts, regardless of etiology. Phacoemulsification, with its numerous advantages, is the most widely used method for cataract removal. It is important to note that while phacoemulsification is considered a safe and effective procedure, there are potential complications that need to be managed. Methods: This study included one hundred eyes of 93 nondiabetic patients undergoing noncomplicated cataract operation at the ophthalmology department at Sohag Teaching Hospital. A preoperative assessment of the best …

Healthcare Providers’ Lived Experiences During Pivotal Change, Lisa Raynelle Shelley

Dissertations

This phenomenological study examined healthcare providers’ lived experiences of psychological safety and administrative leader behaviors that influenced those experiences during pivotal change. While much research addressed psychological safety among frontline healthcare staff, a gap was noticed concerning providers. This study aimed to investigate the impact of psychological safety and administrative support on provider engagement, emotional response, and retention during periods of significant change. Data were collected via a survey containing multiple-choice and open-ended questions, followed by semi-structured interviews. Four findings emerged. First, the providers’ pivotal events generated themes of “workplace power dynamics,” “systemic and organizational change,” “transformational crisis,” and “physical …

Cognitive Rehabilitation Of Brain Tumor Survivors: A Systematic Review, Rabeet Tariq, Hafiza Fatima Aziz, Shahier Paracha, Nida Zahid, Timothy J. Ainger, Farhan A. Mirza, Syed Ather Enam

Neurology Faculty Publications

Background Cognitive decline is commonly seen in brain tumor (BT) patients and is associated with a worsened prognosis. Cognitive rehabilitation (CR) for cancer-related cognitive dysfunction has been widely studied for non-central nervous system cancers; however, recent emerging research has commenced documenting CR strategies for BT patients and survivors. Our objective was to review the current literature on various CR modalities in patients and BT survivors.

Methods The review was conducted in accordance with the PRISMA guidelines. The studies on CR were searched across 3 databases using a predefined search strategy. After removing duplicates, performing initial and full-text screenings, and applying …

To Be Or Not To Be Controlled: The Making Of Thespians In Nineteenth-Century Asylums, Olivia Kurylo

Williams Honors College, Honors Research Projects

Throughout the 1800s, superintendents of insane asylums incorporated the works of Shakespeare into their medical practices. Shakespearean plays became a conduit of power for the asylum superintendents, providing them with a literary model of sanity that they imposed on patients while simultaneously becoming a mode of communication for asylum patients to perform as ‘sane’ in accordance to the superintendents’ definitions. While the superintendents imposed a Shakespearean model of social normalcy onto the patients, the asylum patients used Shakespeare’s plays as a conduit for verbal expression. Essentially, asylums became Shakespearean plays as both the medical staff and the asylum patients employed …

Smart Goal-Setting On Behaviors To Enhance Intrinsic Motivation For Exercise: A Pilot Study With Orangetheory Fitness Participants, Adam Relitz

Williams Honors College, Honors Research Projects

Abstract

PURPOSE: Sustaining long-term motivation for exercise remains a challenge within health and fitness, particularly when extrinsic factors like weight loss dominate motivational strategies. This study investigates the role of behavioral SMART (Specific, Measurable, Achievable, Relevant, Time-bound) goal-setting in fostering intrinsic motivation, a self-driven form of engagement, among participants in a structured fitness program. The primary aim was to evaluate the effectiveness of a SMART goal-setting curriculum in promoting intrinsic motivation and behavior-based goals over external outcomes like losing weight. METHODS: Participants (N = 24) were recruited from a fitness challenge program and selected one behavioral SMART goal from a …

Skinrisk Ai, Spencer Simms

Williams Honors College, Honors Research Projects

SkinRisk AI is an exploration of the opportunities for implementing machine learning (ML) and artificial intelligence (AI) in the medical technology field, specifically in the early detection of skin cancer. This project presents the design, development, and evaluation of a mobile application that allows users to capture images of skin lesions and receive a machine learning assisted risk assessment. The system combines a convolutional neural network (CNN) for image analysis with an intuitive mobile app built using Flutter, FastAPI, and Supabase to deliver real time screening.

Motivated by the rising skin cancer rates and importance of early detection, SkinRisk AI …

A Form-Fitting Model For The Simulation Of Traumatic Brain Injury In Zebrafish, Abigail Armstrong

Williams Honors College, Honors Research Projects

Developing a model to study traumatic brain injury (TBI) is important as it allows for the better understanding of mechanisms underlying the disease to develop effective treatments and other strategies. Creating a realistic simulation of TBI, permits the research of different types of impacts and severities that can be seen in brain function and structure. The simulation is also valuable for monitoring progression of injuries over time and developing personalized treatment plans. Zebrafish, in particular, are prime candidates given their status as model organisms, affordability, and ease of direct observation in the research setting. Overall, efficient and accurate TBI models …

Exploring Familial Lymphoma And Chronic Lymphocytic Leukemia, Rhea Mahajan

Williams Honors College, Honors Research Projects

This project aims to investigate the familial incidence of lymphoma and Chronic Lymphocytic Leukemia (CLL) within the patient population at Gabrail Cancer Center (GCC). Using the Electronic Medical Record from the past ten years, patients with current or historical diagnoses of lymphoma or CLL will be identified and surveyed (along with using patient records, including consult notes, hospital notes, MD notes, etc.) to extract any family history of these cancers. The project will analyze clinical outcomes in these cases, and analyze whether there were multiple family members to have been affected by lymphoma or CLL (or other cancers), and see …

Indirect Calorimetry: The Effects Of Overfeeding And Underfeeding Mechanically Ventilated Patients, Hailee Schirm

Williams Honors College, Honors Research Projects

This research focuses on the effects of overfeeding and underfeeding mechanically ventilated patients in the ICU and how indirect calorimetry plays a role in improving patient outcomes. Research was pulled from eight peer reviewed sources written within the last ten years to support this statement. It includes multiple types of studies including but not limited to a retrospective cohort study, meta-analysis, review, and deterministic cost-sequences analysis. Indirect calorimetry measures carbon dioxide production and oxygen consumption to calculate energy expenditure and determine the number of calories needed to sustain one’s body. This allows us to determine the number of calories a …

Cochlear Electrode Insertion Training Model, Sarah Powell, Kaelyn E. Kraley, Nathan J. Smith

Williams Honors College, Honors Research Projects

Cochlear implant surgery is a delicate procedure performed by Otolaryngologists (ENTs) to implant an electronic device into the inner ear to provide a sense of sound for people who are profoundly deaf or hard of hearing. The current practices of training involve cadavers and 3D-printed models. Cadavers are commonly used but are expensive, single-use, and do not provide visual and haptic feedback, which are essential for medical students. 3D printed models are less commonly used and are hard to fabricate and not as realistic. If medical students are not properly trained for this delicate procedure, then risks are significantly increased …

Positive Coping Within The Nicu, Abrielle Kautza, Allison Garrett, Manaar Muhammad

Williams Honors College, Honors Research Projects

The focus of this paper is how nursing staff can cultivate positive coping strategies for both the parents and babies in the neonatal intensive care unit. This was done by analyzing four specific nursing interventions: music therapy, baby cuddling, spirituality, family centered care. The purpose of researching these interventions is because knowledge on their benefits allows for positive coping in both the parents and their baby. The articles chosen were retrieved from EbscoHost, Pubmed, and Wiley Online Library. The articles are primarily levels four and five on the hierarchy of evidence. Family centered care implementation showed a positive effect on …

Critical Analysis Of Gestational Diabetes Risk Factors: A Systematic Review, Madison Keich, Madeleine Ray, Mia Ross

Williams Honors College, Honors Research Projects

Gestational Diabetes Mellitus (GDM) is a common complication of pregnancy that causes an increased blood sugar that can affect both the mother's and baby’s health. A variety of factors can increase the risk of developing the disease, including race, socioeconomic status, and prenatal education. Each of these factors contributes to the experience of one’s maternal care. Expecting mothers may not understand how significant GDM is, and its potential to result in negative outcomes. It is important to review these factors, acknowledge them, and help reduce health disparities caused by them. Nurses are vital to assessing and delivering patient education on …

Psychological Interventions In The Work Environment And Reducing Burnout In Critical Care Nurses, Amelia Bloom, Isabella Tisevich

Williams Honors College, Honors Research Projects

Burnout is an increasing issue in the nursing field, particularly for critical care nurses. The purpose of this systematic review is to discover how the work environment impacts burnout of critical care nurses, and how different psychological interventions instituted by the workplace impact their burnout levels. The PICO question is: In critical care nurses, do work environments that provide psychological interventions compared to work environments that do not provide psychological interventions document outcomes of less burnout? The articles used within this systematic review were found using the databases Academic Search Complete and PubMed. Articles were selected based on the inclusion …

Perceived Shoulder Discomfort In Adolescent Swimmers, Abigail Daniel

Williams Honors College, Honors Research Projects

Competitive swimming is a sport that athletes traditionally start at a young age, training for many years to build up an aerobic base, learn the best techniques of the sport, and gain experience racing. While this increases the ability to perform and adapt to training in the sport, it also can lead to shoulder tightness, soreness, and even injury. PURPOSE: To investigate any correlation between the perceived shoulder discomfort of adolescents to flexion and extension measurements. METHODS: Participants (N=25) were recruited in person from a swimming club. Swimmers were between 13-18 years old and varied in participation level from recreational …

Effects Of Exercise On Cognitive Performance, Autumn Bailey

Williams Honors College, Honors Research Projects

This research project “Effects of Exercise on Cognitive Performance” will be conducted with the purpose of determining the relationship between exercise and cognitive performance. The relationship between injury and cognitive performance will also be investigated. In order to investigate these relationships 60 participants who are current students at the University of Akron will be asked to complete three cognitive assessments, one while at rest, one while riding an exercise bike, and one following the completion of exercise. The results of these three assessments will be compared to determine the relationship between cognitive performance in all three states. Participants will include …