Medicine and Health Sciences Commons^™

Promoting Parent-Child Connectedness: Insights From A Parent Education Training., Bisola E. Duyile, Robyn Becker, Kate Papas, Shanta K. Pamphile

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Purpose: This study explores the interrelationship of speech, language, and literacy development, parentchild connectedness, and children’s mental health when viewed as social determinants of health, specifically among families of children with developmental disabilities. Through interprofessional collaboration, researchers aim to identify effective strategies that parents can use to enhance their children’s communication skills and emotional well-being.

Methods: A mixed methods design was employed, involving a post-workshop survey completed by five mothers. The quantitative component included Likert scale items to measure satisfaction with social support. We also evaluated satisfaction with the workshop. The qualitative component comprised openended questions about newly learned tools …

A Systematic Review Of Reading Comprehension Assessment And Intervention In Minimally And Nonspeaking Autistic Children, Grace T. Clark, Madison Skibicki, Gabriella Pesantes

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Up to 25% of autistic individuals are minimally or nonspeaking and require augmentative and alternative communication (AAC). While literacy instruction for this group is increasing, limited research has examined their reading comprehension. This systematic review examined assessment and intervention practices targeting reading comprehension in autistic children who use AAC. A search of five databases yielded 586 articles, of which 6 studies met inclusion criteria. Studies were included if they featured autistic participants under 18 who were minimally or nonspeaking and addressed reading comprehension beyond single-word decoding. Findings varied widely in participant profiles, comprehension targets, and methodological rigor. There is a …

Orthographic Support For Verb Identification In Typically Developing Three-Year-Old Children, Grace T. Clark, Christina Reuterskiold

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Children, as young as four years of age, have demonstrated enhanced noun learning when presented with orthographic representations during word learning tasks. This study sought to determine if three-year-old typically developing children would demonstrate an orthographic facilitation effect during an asynchronous computer-based verb learning task. One-hundred ten children were taught 8 novel verbs by presenting videos of novel actions paired with novel labels in sentence frames. Four novel verbs were taught with orthographic support present and four were taught without orthographic support. Participants were exposed to the words a total of two times and then given a post-test to assess …

Verbs Are Tricky: Does Orthography Support Verb Identification In Typically Developing Children Ages 3–8?, Grace T. Clark, Gabriella Pesantes, Madison Skibicki

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Purpose:
This study examined whether orthographic representations—seeing a printed word while hearing it—facilitate verb identification accuracy in typically developing children and whether developmental or literacy factors modulate this effect.

Method:
One hundred eight English-speaking children ages 3–8 years (M = 5.86) completed a web-based verb learning task through Children Helping Science. Participants were randomly assigned to an orthography-present or orthography-absent condition while learning six novel verbs paired with dynamic action videos. Accuracy during a two-alternative forced-choice test was coded from parent-verified pointing responses. Caregivers completed a literacy interest questionnaire, and children completed a letter–sound correspondence task. Multilevel logistic regression …

3d Bioprinting Technology Innovation In Female Reproductive System, Siyao Chen, Tongxin Wang, Jiaqi Chen, Mingxing Sui, Luyao Wang, Xueyu Zhao, Jianqiao Sun, Yingli Lu

Department of Obstetrics & Gynecology Faculty Publications

Several diseases affect the female reproductive system, and both disease factors and treatments impact its integrity and function. Consequently, understanding the mechanisms of disease occurrence and exploring treatment methods are key research focuses in obstetrics and gynecology. However, constructing accurate disease models requires a microenvironment closely resembling the human body, and current animal models and 2D in vitro cell models fall short in this regard. Thus, innovative in vitro female reproductive system models are urgently needed. Additionally, female reproductive system diseases often cause tissue loss, yet effective tissue repair and regeneration have long been a bottleneck in the medical field. …

Predicting Mental Health Disparities Using Machine Learning For African Americans In Southeastern Virginia, Ismail El Moudden, Michael C. Bittner, Matvey V. Karpov, Isaac O. Osunmakinde, Akosua Acheamponmaa, Breshell J. Nevels, Mamadou T. Mbaye, Tonya L. Fields, Karthiga Jordan, Messaoud Bahoura

Department of Obstetrics & Gynecology Faculty Publications

This study examined mental health disparities among African Americans using AI and machine learning for outcome prediction. Analyzing data from African American adults (18–85) in Southeastern Virginia (2016–2020), we found Mood Affective Disorders were most prevalent (41.66%), followed by Schizophrenia Spectrum and Other Psychotic Disorders. Females predominantly experienced mood disorders, with patient ages typically ranging from late thirties to mid-forties. Medicare coverage was notably high among schizophrenia patients, while emergency admissions and comorbidities significantly impacted total healthcare charges. Machine learning models, including gradient boosting, random forest, neural networks, logistic regression, and Naive Bayes, were validated through 100 repeated 5-fold cross-validations. …

Treatment Effects Of Genital Mycoplasma Species In High-Risk Pregnant Individuals: A Retrospective Cohort Study, Takashi Yoshimasu, Tasuku Inao, Tetsuya Kawakita

Department of Obstetrics & Gynecology Faculty Publications

Objective

We aimed to estimate the causal effect of treatment for genital Mycoplasma species on preterm birth (PTB) and spontaneous abortion (SA). We also evaluated treatment effects separately for cases with co-infection of Ureaplasma and Mycoplasma species.

Methods

This was a retrospective observational cohort study at a single center. Singleton mothers with one or more risk factors for PTBs were screened and treated for genital Mycoplasma species. The treatment was repeated based on polymerase chain reaction (PCR) results after each course. We applied inverse probability treatment weighting, and risk differences (RDs) of the treatment effect on pregnancy outcomes were estimated …

Automated Thermo-Mechanical Therapy For Immediate Relief In Chronic Non-Specific Lower Back Pain (Cnslbp): A Randomized Controlled Trial, Kyle V. Donnery

Dissertations and Theses

Objective: Chronic non-specific lower back pain (cNSLBP) is a prevalent and disabling condition, imposing a substantial socioeconomic burden due to high healthcare costs and productivity losses, with limited accessible and effective long-term treatment options. Automated Thermo-mechanical Therapy (ATT) is a promising, non-drug intervention that leverages innovative technical advances to provide multimodal pain relief, offering accessibility and low-cost delivery. This study tested ATT for immediate pain relief in individuals with cNSLBP in a single-session, double-blind, randomized controlled trial.

Methods: Forty participants with cNSLBP were randomly assigned to receive either active ATT (n=20) or control ATT (n=20) in a 40-minute session. The …

Training Set Augmentation And Harmonization Enables Radiomic Models To Detect Early Onset Of Lung Cancer, Claire Huchthausen, Menglin Shi, Gabriel L.A. Sousa, James Larner, Einsley Janowski, Jonathan Colen, Krishni Wijesooriya

Data Science Faculty Publications

Radiomics-based machine learning models have the potential to detect lung cancer at inception from CT scans and transform patient outcomes. Low malignancy rates in early-development pulmonary nodules (PNs) and variable image acquisition hinder development of clinically applicable radiomics-based early detection models. To address these challenges, we augmented training using later-development PNs and harmonized for acquisition effects. We first trained machine learning models to predict PN malignancy using radiomic features from scans of early-development benign and malignant PNs (n = 187) harmonized using ComBat. Observing near-chance performance, we augmented training with later-development benign and malignant PNs (n = 225). We evaluated …

Lis1 Depletion In Adult Mouse Projection Neurons Causes Neurodegeneration And Severe Neurological Phenotypes, Anne Ventrone

Theses and Dissertations

Proper LIS1 function is crucial for human brain development, as mutations in LIS1 lead to lissencephaly, a severe neurodevelopmental disorder caused by defective proliferation, differentiation and migration of neural precursors. Our understanding of LIS1's functions after brain development is limited. LIS1 regulates cytoplasmic dynein 1 (dynein), an essential microtubule motor protein in cell division and migration, but also a cellular transport motor. We previously showed that tamoxifen (TX)-induced global knockout of LIS1 using a Cre/Lox system (Act-Lis1iKO) in young adult mice results in severe neurological defects and rapid lethality. This strongly supports LIS1's critical post- developmental role, but the underlying …

Racial Disparities In Adherence To Diabetes Management Guidelines: The Impact Of Immigration Status Among Asian Populations In The U.S., Aliya Kuerban Phd, Fnp-Bc, Ms, Ma, Rn, Yuging Zhang

Nursing: Faculty Presentations

Background/Purpose

Asian populations in the U.S. demonstrate lower adherence to diabetes management guidelines compared to other racial groups. The American Diabetes Association (ADA) recommends a minimum of two annual A1C tests to manage diabetes effectively. This study examines racial disparities in adherence to these guidelines, focusing on the impact of immigration-related factors and patient perceptions of provider communication. The findings aim to identify barriers and inform strategies to enhance diabetes management and improve patient-provider interactions in underserved communities.

Theoretical/Conceptual Framework

This study employs a modified patient-provider communication model as its theoretical framework, emphasizing how effective communication can influence adherence to …

Intracellular Survival Of Staphylococcus Aureus In Macrophages During Osteomyelitis, William A. Lathram, Christopher D. Radka

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Staphylococcus aureus, traditionally viewed as an extracellular pathogen, is increasingly recognized for its ability to persist intracellularly, particularly within macrophages. This intracellular lifestyle is central to osteomyelitis, a chronic bone infection characterized by persistent inflammation, bone destruction, and impaired repair. Within bone, S. aureus exploits macrophage plasticity by driving a shift from pro-inflammatory, bactericidal M1-like states to anti-inflammatory, tissue-reparative M2-like phenotypes. This polarization suppresses immune clearance and promotes an environment conducive to bacterial survival and dissemination. Additional strategies – including biofilm formation, small colony variants, and inhibition of phagolysosomal killing – further enhance persistence and immune evasion. While these …

Serglycin Controls Megakaryocyte Retention Of Platelet Factor 4 And Influences Megakaryocyte Fate In Bone Marrow, Joshua Lykins, Isabelle C. Becker, Virginia Camacho, Hammodah Rawhi Hammodah Alfar, Joonwoo Park, Joseph Italiano, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Megakaryocytes (MKs) produce platelets, and similar to other hematopoietic progenitors, they are involved in homeostatic aspects of their bone marrow niche. MKs release and endocytose various factors, such as platelet factor 4 (PF4)/CXCL4. Here, we show that the intra-α-granular proteoglycan, serglycin (SRGN), plays a key role in this process by retaining PF4, and perhaps other factors, during MK maturation. Immature, SRGN–/– MKs released ~80% of their PF4, and conditioned media from these cells negatively affected wild-type MK differentiation in vitro. This was replicated in wild-type MKs by treatment with the polycation surfen, a known inhibitor of glycosaminoglycan (GAG)/protein interactions. In …

Abcg5/Abcg8-Independent Mechanisms Fail To Maintain Sterol Balance In Mice Fed A High-Cholesterol Diet, Garrett B. Anspach, Rupinder Kaur, Isha Chauhan, Erika L. Savage, Brittney Poole, Victoria P. Noffsinger, Xiaoming Fu, Zeneng Wang, Clairity Voy, Ryan E. Temel, Scott M. Gordon, Robert N. Helsley, Gregory A. Graf

Saha Cardiovascular Research Center Faculty Publications

The ABCG5/ABCG8 (G5G8) sterol transporter opposes the accumulation of dietary xenosterols but is also the primary mediator of biliary cholesterol secretion. In humans and in mouse models of disrupted biliary cholesterol secretion, fecal neutral sterols (FNSs) remain constant, indicating the presence of an alternate pathway for cholesterol excretion. Transintestinal cholesterol elimination or excretion (TICE) is thought to compensate for biliary disruptions and G5G8 insufficiency. We sought to measure the compensatory increase in intestinal cholesterol secretion and provide mechanistic insight for how TICE maintains sterol balance in the absence of hepatic G5G8. Differences were not observed in FNSs between control, acute, …

Sexual And Reproductive Health Access Among Racial/Ethnic Minority College Students, Srithanvi Pasunuri

Honors Undergraduate Theses

Sexual and reproductive health (SRH) is critical for individual well-being, yet significant disparities in access persist among racial and ethnic minority college students in the United States. These inequities, driven by systemic barriers such as financial constraints, cultural stigmas, and inadequate campus resources, contribute to higher rates of unintended pregnancies, sexually transmitted infections (STIs), and poor health outcomes within these populations. This systematic review aims to identify and synthesize existing literature on the barriers to SRH access for racial and ethnic minority college students, explore how cultural, social, and institutional factors influence service utilization, and assess interventions proven effective in …

The Association Between Pain Sensitivity And Low Energy Availability, Sleep, Mental Health, And Stress In Female Endurance Athletes, Taylor R. Moler

Honors Undergraduate Theses

The disruption of certain physiological functions due to low energy availability (LEA) in female endurance athletes is a prominent concern. This condition resulting from LEA has been described as Relative Energy Deficiency in Sport (RED-S), which can include alterations in metabolism, menstrual function, bone deposition and resorption, mental well-being, and more. The goal of this study was to determine whether pain sensitivity was associated with LEA, sleep, mental health, and stress in female endurance athletes. Participants completed a demographic survey, the Low Energy Availability in Females Questionnaire (LEAF-Q), the Pittsburgh Sleep Quality Index (PSQI), the Patient Health Questionnaire (PHQ-4), and …

Navigating The Intersections: Immigration, Diversity Of The Workforce, Precarious Work, And Vulnerabilities In Occupational Safety And Health, Daniel Côté, Jessica Dubé

Éditoriaux, lettres à l'éditeur

Dans un contexte de mondialisation croissante, la migration est une réalité incontournable qui expose les travailleurs migrants et autochtones à des conditions précaires et à des vulnérabilités accrues en matière de santé et sécurité du travail (SST). Les formes d’emploi précaires – contrats temporaires, travail à temps partiel ou informel – touchent de manière disproportionnée ces travailleurs, limitant leur accès aux droits et protections. Les travailleurs autochtones, particulièrement en milieu rural et dans des secteurs à risque, font face à des défis similaires en raison de marginalisations historiques et structurelles.

Ce texte présente les cinq articles de la section spéciale …

Role Of Online Health Information Resources In Shaping Self Confidence Of Nursing And Midwifery Students In The Digital Era At Aga Khan University, Tanzania, Getrude Ngowi, Jackline Estomihi Kiwelu

Book Chapters / Conference Papers

Digital technologies have transformed the way people learn in the current age. Innovative multimedia online nursing and midwifery information resources have improved nursing education and brought about adaptive, interactive, and collaborative learning. This study aims to find out whether the online nursing information resources provided at Aga Khan University Tanzania are shaping the self-confidence of nurses and midwives in the digital era, to understand gaps and areas for improvement. This study used both quantitative and qualitative research approach were used. The researchers collecting data using online Google Forms, which were analysed thematically through Atlas ti. The results revealed that persistent …

Associations Between Perceived Discrimination And Sleep Health: Results From The Future Of Families And Child Wellbeing Young Adult Sleep Study, Angel I.M. Collie, Adwoa Dadzie, David A. Reichenberger, Lindsay A. Master, Gina M. Mathew, Lauren E. Hale, Anne-Marie Chang, Orfeu M. Buston

Department of Preventive Medicine Faculty Publications

Objectives. We investigated cross-sectional associations between perceived discrimination and actigraphic sleep health among young adults.

Methods. Data from the age 22 wave (mean±SD age=22.1±0.4 years) of the Future of Families and Child Wellbeing Young Adult Sleep Study, a national birth cohort originally drawn from 20 U.S. cities, included young adults (n=334; 68.9% Black, 14.7% Hispanic/Latino) who self-reported experiences of discrimination. Wrist-worn actigraphy was collected across ~2 weeks from 2020-2024 and measures included sleep duration, onset, midpoint, maintenance efficiency (SMeff), and wake after sleep onset (WASO). Multiple linear regression models examined the association between experiencing a specific type of …

Dentistry And The Law: The Difference Between ‘Non-Covered’ Vs. ‘Disallowed’ Services, Daniel Schulte Jd

The Journal of the Michigan Dental Association

The article clarifies the distinction between "non-covered" and "disallowed" services in dental plan audits. Non-covered services are not included in the patient’s dental plan, often due to plan limitations, while disallowed services are covered but deemed non-payable due to issues like claim deficiencies or lack of documentation. Dentists must review their contracts to understand obligations regarding non-covered services and ensure compliance with HIPAA for patient-paid services. For disallowed services, contesting decisions may be possible depending on the agreement with the dental plan.

Staff Matters: Why Are Our Employees Leaving? And How Do We Keep Them?, Jodi Schafer Sphr, Shrm-Scp

The Journal of the Michigan Dental Association

The article addresses the challenges of staff attrition in dental practices, emphasizing its costly impact and the need to understand its causes. Common reasons for attrition include low compensation, high workloads, poor management practices, and lack of career development opportunities. Solutions involve gathering feedback through exit interviews, improving salaries and benefits, balancing workloads, enhancing management styles, and offering career growth. Proactive measures can help retain staff and create a stable, supportive work environment.

Mda Foundation: Great Things Are Ahead For The Mda Foundation In 2025, Anne Berquist

The Journal of the Michigan Dental Association

The MDA Foundation expresses heartfelt gratitude to donors and volunteers who contributed to improving oral health care access and education in 2024. Efforts included funding free and reduced-cost clinics, awarding scholarships, and hosting the Mission of Mercy (MOM) free clinic in Flint. For 2025, plans include the Sparkling Smiles fundraising event during the MDA Annual Session in Detroit and laying the groundwork for next year’s MOM in Kalamazoo. The Foundation encourages applications for grants (deadline: May 1) and scholarships (applications open Aug. 1), continuing its commitment to supporting Michigan communities and dental students.

Association Between Rurality And Race/Ethnicity And Pediatric Cancer Early Mortality: A Population-Based Cohort Study Using Seer Data From 2000 To 2021, Kiersten Preuss, Emma Hymel, Melissa Acquazzino, Shinobu Watanabe-Galloway

Journal Articles: Epidemiology

BACKGROUND: Pediatric cancer mortality rates have steadily declined since 2009, but over a thousand deaths still occur annually. While existing research highlights the effects of race/ethnicity and rurality on overall survival, few studies have specifically analyzed these factors in relation to early mortality, defined as death within 12 months of diagnosis.

PROCEDURE: This study utilized SEER Research Plus Limited-Field Data (2000-2021) to examine the association between race/ethnicity, rurality, and early mortality in pediatric cancer patients. A cohort of 138,648 individuals was analyzed using Cox proportional hazards regression models to calculate hazard ratios and 95% confidence intervals (CIs).

RESULTS: The results …

Integrating Human And Animal Health In The Stop Spillover Outbreak Scenarios, Kathleen E. Angell, He Julia Bai, Katherine C. Prager, Janetrix H. Amuguni, Felicia B. Nutter, Jonathan D. Gass Jr, David Brett-Major

Journal Articles: Epidemiology

OBJECTIVES: To generate and employ scenarios of sentinel human and animal outbreak cases in local contexts that integrate human and animal health interests and practices and facilitate outbreak risk management readiness.

METHODS: We conducted a scoping review of past outbreaks and the strengths and weaknesses of response efforts in USAID STOP Spillover program countries. This information and iterative query-and-response with country teams and local stakeholders led to curated outbreak scenarios emphasizing One Health human:animal interfaces at sub-national levels.

RESULTS: Two core scenarios were generated adapted to each of 4 countries’ pathogen priorities and workflows in Africa and Asia, anchoring on …

Schistosoma Haematobium Infection And Associated Risk Factors Among Pre-School Age Children In Gambella, Ethiopia, Tigist Mohammed, Abraham Degarege, Mulugeta Aemero, Abebe Animut, Yohannes Negash, Yirgalem Gebrehiwot, Berhanu Erko

Journal Articles: Epidemiology

Background

Method

How Do Patient-Provider Relationships Affect Patient Satisfaction?, Rose D. Lightspeed

Anthós

This article reviews studies on patient satisfaction within the U.S. healthcare system to investigate how physicians’ behavior influences patients’ reported quality of care. Medical negligence, neglect, and cognitive biases are identified from the reviewed literature as physician behaviors that affect the patient-provider relationship and patient satisfaction. Emphasizing patient satisfaction and involvement in their care as important considerations when evaluating patient-provider relationships, Lightspeed underscores how the complex dynamic between patient and provider–including physicians’ reported feeling of inadequate interpersonal skills and patients’ sensitivity to dismissive communication–contributes to reduced satisfaction rates. Lightspeed argues that increasing physician awareness of these factors that influence patient …

Dialing In Or Dialing Out? The Relationships Between State Telemedicine Law And Access To Buprenorphine, Stacey A. Tovino

Faculty Articles

This Article begins by reporting the results of a comprehensive 50-state survey assessing state laws and other state sources governing the telemedicine induction (“tele-induction”) and subsequent telemedicine prescription (“tele-prescription”) of buprenorphine for the treatment of opioid use disorder (“OUD”) following the expiration of the COVID-19 public health emergency (“PHE”). Original, concrete findings include: (1) the glaring patchwork of state law governing the tele-induction and subsequent tele-prescription of buprenorphine for the treatment of OUD in the United States; (2) the variety of primary authorities and secondary sources that house relevant permissions, prohibitions, and affiliated requirements; (3) the number of primary authorities …

Learning From Leads: A 1d Dilated Resnet For Ecg Chagas Disease Screening, Somesh Saini, Matheus Lima Diniz Araujo

Student Scholarship

No abstract provided.

Genetic Associations Among Inflammation, White Matter Architecture, And Extracellular Free Water, Amanda L. Rodrigue, Emma M. Knowles, Josephine Mollon, Samuel R. Mathias, Juan M. Peralta, Ana C. Leandro, Peter T. Fox, Peter Kochunov, Rene L. Olvera, Laura Almasy, Joanne E. Curran, John Blangero, David C. Glahn

School of Medicine Publications

Phenotypic and genetic relationships between white matter microstructure (i.e., fractional anisotropy [FA]) and peripheral inflammatory responses (i.e., circulating cytokines) have important implications for health and disease. However, it is unclear whether previously discovered genetic correlations between the two traits are due to tissue‐specific white matter architecture or increased free water in the extracellular space. We applied a two‐compartment model to diffusion tensor imaging (DTI) data and estimated tissue‐specific white matter microstructure (FAT) and free water volume (FW). We then quantified their heritability and their genetic correlations with two peripherally circulating proinflammatory cytokines (IL‐8 and TNFα), and compared these correlations to …

Female Brain And Endocrinological Research–Veteran (Fember-Vet) Study: A Study Protocol For Identifying Endocrinological, Lifestyle And Psychosocial Determinants Of Brain Health Outcomes In Female Veterans For Future Intervention Success, Tamlyn Watermeyer, Elliott Atkinson, Glyn Howatson, Gill Mcgill, Christina Dodds, Paul Ansdell, Chinedu Momoh

Brain and Mind Institute

Background: Recent studies have demonstrated a greater risk of dementia in female veterans compared to civilians; with the highest prevalence noted for former service women with a diagnosis of psychiatric (trauma, alcoholism, depression), and/or a physical health condition (brain injury, insomnia, diabetes). Such findings highlight the need for increased and early screening of medical and psychiatric conditions, and indeed dementia, in the female veteran population. Further, they call for a better understanding of the underlying biopsychosocial mechanisms that might confer heightened risk for female veterans, to tailor preventative and interventional strategies that support brain health across the lifespan.

Methods …