Medicine and Health Sciences Commons^™

A Fatal Case Of Central Pontine Myelinolysis With Chronic Inflammatory Demyelinating Polyneuropathy, Miguel Serrano, Grant Read, Karen Joseph

West Florida Division GME Research Day 2025

No abstract provided.

The Safety Of Catheter Aspiration Of Tricuspid Valve Endocarditis Versus Open Surgery, Ali Alkhayru, Rohan Shah, Luke Thompson, Marek Solomianko, Rahul Mhaskar, Ali Abdul-Jabbar

West Florida Division GME Research Day 2025

No abstract provided.

Inked And Infected: A Case That Highlights The Emerging Concern Of Tattoo-Associated Mycobacterium Abscessus, Tory Starzyk, Neena Edupuganti

West Florida Division GME Research Day 2025

No abstract provided.

Use Of Kratom Tea Supplements For The Treatment Of Self-Diagnosed Anxiety And Its Association With New Onset Seizures In A Young Adult Male, Gloria Travieso-Zadan, Lucas Zadan, Daniel Breznau

West Florida Division GME Research Day 2025

No abstract provided.

Beyond Dry Eyes: Connecting The Dots Between Primary Sjogren’S Syndrome And Interstitial Lung Disease, Kathryn Weston, Tiffany Laitano, Gabriel Martello, Robert Digiovanni, Salah Al-Andary

West Florida Division GME Research Day 2025

No abstract provided.

Breaking The Flow: Endovascular Repair Of A Coronary Cameral Fistula, Alexander S. Yaylayan, Athanasios Larkin, Kruten M. Patel, Jesse Klein

West Florida Division GME Research Day 2025

No abstract provided.

The Final Beat: A Case Report On Recurrent Endocarditis And The Ethical Dilemmas Of Surgical Futility, Jenie Yeh, Marek Solomianko, Robert Sanchez

West Florida Division GME Research Day 2025

No abstract provided.

Implementation Of Formalized Education Of Ultrasound-Guided Intravenous Peripheral Line Placement In A Family Medicine Residency, Lucas Zadan, Gloria Travieso-Zadan, Sean Quinonez

West Florida Division GME Research Day 2025

No abstract provided.

Cochlear Implantation With Sporadic Inner Ear Schwannomas: Outcomes In 106 Patients From An International Multi-Institutional Study, John P. Marinelli, Torsten Rahne, James R. Dornhoffer, Christine M. Lohse, Justin Cottrell, J. Thomas Roland, Nicholas J. Thompson, Kevin D. Brown, Jacob C. Lucas, Seilesh C. Babu, Nathan R. Lindquist, Elizabeth L. Perkins, Donald Tan, John I. Lane, Jacob B. Hunter, Erin Harvey, Nicholas L. Deep, Samantha Y. Cerasiello, Matthew L. Kircher, Mana Espahbodi, Evan L. Tooker, Niels Cramer West, Per Caye-Thomasen, Matthew L. Carlson, Stefan K. Plontke

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

OBJECTIVE: To evaluate cochlear implant speech perception among patients with sporadic inner ear schwannoma who underwent ipsilateral implantation.

STUDY DESIGN: Retrospective multi-institutional cohort study.

SETTING: Eleven tertiary academic medical centers across Germany, Denmark, and the United States.

PATIENTS: One hundred six patients with sporadic inner ear schwannoma who received an ipsilateral cochlear implant from 2011 to 2022.

INTERVENTIONS: Ipsilateral cochlear implantation with observation, stereotactic radiosurgery, or microsurgery for tumor management.

MAIN OUTCOME MEASURES: Monosyllabic speech perception testing scores and rates of open-set speech perception.

RESULTS: Among 106 patients studied, 101 (95%) achieved open-set speech perception with a median of 24 …

Multidisciplinary Lethal Means Safety Counseling Design And Implementation: Training And Identifying Barriers In A Children's Hospital, Cassandra L. Stegall, Brendon Carnell, Jaime M. Golden, Rupa Kapoor, John H. Fanton, Paul C. Mullan, Alexandra P. Leader

Department of Pediatrics Faculty Publications

Background

Access to lethal means contributes significantly to suicide completion. Lethal means safety counseling (LMSC) is an injury prevention strategy to limit access to firearms, medications, and other means of injury. Not previously evaluated in the trauma setting, this study aims to design and implement a standardized LMSC protocol for pediatric patient discharge education in emergency (ED), trauma, and inpatient psychiatry settings.

Methods

A single-center quality improvement study at an academic pediatric urban tertiary Level-one trauma center was performed from July 2023 to February 2024. Protocol was implemented for pediatric patients discharged from three departments: ED, surgery trauma service, and …

Adapting The Minority Stress Model Among Middle-Aged And Older Adults With And Without Hiv: Understanding The Interplay Between Minority Stress, Mental Health, And Sexual Risk Behaviors, Alexis R Long Thompson

All ETDs from UAB

This dissertation aims to adapt Meyer’s Minority Stress Model to understand the interplay between minority stress, mental health, and sexual risk behaviors among middle-aged and older adults with and without HIV. The study utilizes data from the MACS WIHS Combined Cohort Study, focusing on adults aged 40 and older. It examines the relationships between perceived stress, psychosocial factors (depression, substance use, social support), and sexual risk behaviors, considering the impact of minority identities such as race, gender, sexual orientation, and HIV status. The findings highlight significant differences in perceived stress, depressive symptoms, substance use, and social support across different intersectional …

Improved Survival With Phosphodiesterase-5 Inhibitor Use In Men With Male-Predominant Cancers: Real-World Large Database Study, Daniel Uralov, Sarah R. Harrington, Hani Samarah, Anika S. Walia, Marina Aweeda, Manal U. Mustafa, Parvesh Kumar, Andrew Briskin, Julian Jackson, Eric Mastrolonardo, Adam J. Luginbuhl

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

INTRODUCTION: Phosphodiesterase-5 (PDE5) inhibitors, commonly prescribed for erectile dysfunction, may exhibit immunomodulatory properties by reducing myeloid-derived suppressor cell activity and enhancing T-cell responses. This study evaluated the association between PDE5 inhibitor use and overall survival (OS) in male-predominant solid organ malignancies.

METHODS: Male-predominant solid tumors were identified using male-to-female incidence ratio ≥3:1 in SEER database: prostate, bladder, colon, esophageal, hypopharyngeal, laryngeal, tonsillar, and testicular cancers. Using the TriNetX Research Network, we compared male patients prescribed PDE5 inhibitors within 6 months of cancer diagnosis to those without PDE5 exposure. Propensity score matching (PSM) was performed on demographic, clinical, and oncologic variables. …

Promoting Parent-Child Connectedness: Insights From A Parent Education Training., Bisola E. Duyile, Robyn Becker, Kate Papas, Shanta K. Pamphile

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Purpose: This study explores the interrelationship of speech, language, and literacy development, parentchild connectedness, and children’s mental health when viewed as social determinants of health, specifically among families of children with developmental disabilities. Through interprofessional collaboration, researchers aim to identify effective strategies that parents can use to enhance their children’s communication skills and emotional well-being.

Methods: A mixed methods design was employed, involving a post-workshop survey completed by five mothers. The quantitative component included Likert scale items to measure satisfaction with social support. We also evaluated satisfaction with the workshop. The qualitative component comprised openended questions about newly learned tools …

A Systematic Review Of Reading Comprehension Assessment And Intervention In Minimally And Nonspeaking Autistic Children, Grace T. Clark, Madison Skibicki, Gabriella Pesantes

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Up to 25% of autistic individuals are minimally or nonspeaking and require augmentative and alternative communication (AAC). While literacy instruction for this group is increasing, limited research has examined their reading comprehension. This systematic review examined assessment and intervention practices targeting reading comprehension in autistic children who use AAC. A search of five databases yielded 586 articles, of which 6 studies met inclusion criteria. Studies were included if they featured autistic participants under 18 who were minimally or nonspeaking and addressed reading comprehension beyond single-word decoding. Findings varied widely in participant profiles, comprehension targets, and methodological rigor. There is a …

Orthographic Support For Verb Identification In Typically Developing Three-Year-Old Children, Grace T. Clark, Christina Reuterskiold

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Children, as young as four years of age, have demonstrated enhanced noun learning when presented with orthographic representations during word learning tasks. This study sought to determine if three-year-old typically developing children would demonstrate an orthographic facilitation effect during an asynchronous computer-based verb learning task. One-hundred ten children were taught 8 novel verbs by presenting videos of novel actions paired with novel labels in sentence frames. Four novel verbs were taught with orthographic support present and four were taught without orthographic support. Participants were exposed to the words a total of two times and then given a post-test to assess …

Verbs Are Tricky: Does Orthography Support Verb Identification In Typically Developing Children Ages 3–8?, Grace T. Clark, Gabriella Pesantes, Madison Skibicki

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Purpose:
This study examined whether orthographic representations—seeing a printed word while hearing it—facilitate verb identification accuracy in typically developing children and whether developmental or literacy factors modulate this effect.

Method:
One hundred eight English-speaking children ages 3–8 years (M = 5.86) completed a web-based verb learning task through Children Helping Science. Participants were randomly assigned to an orthography-present or orthography-absent condition while learning six novel verbs paired with dynamic action videos. Accuracy during a two-alternative forced-choice test was coded from parent-verified pointing responses. Caregivers completed a literacy interest questionnaire, and children completed a letter–sound correspondence task. Multilevel logistic regression …

3d Bioprinting Technology Innovation In Female Reproductive System, Siyao Chen, Tongxin Wang, Jiaqi Chen, Mingxing Sui, Luyao Wang, Xueyu Zhao, Jianqiao Sun, Yingli Lu

Department of Obstetrics & Gynecology Faculty Publications

Several diseases affect the female reproductive system, and both disease factors and treatments impact its integrity and function. Consequently, understanding the mechanisms of disease occurrence and exploring treatment methods are key research focuses in obstetrics and gynecology. However, constructing accurate disease models requires a microenvironment closely resembling the human body, and current animal models and 2D in vitro cell models fall short in this regard. Thus, innovative in vitro female reproductive system models are urgently needed. Additionally, female reproductive system diseases often cause tissue loss, yet effective tissue repair and regeneration have long been a bottleneck in the medical field. …

Predicting Mental Health Disparities Using Machine Learning For African Americans In Southeastern Virginia, Ismail El Moudden, Michael C. Bittner, Matvey V. Karpov, Isaac O. Osunmakinde, Akosua Acheamponmaa, Breshell J. Nevels, Mamadou T. Mbaye, Tonya L. Fields, Karthiga Jordan, Messaoud Bahoura

Department of Obstetrics & Gynecology Faculty Publications

This study examined mental health disparities among African Americans using AI and machine learning for outcome prediction. Analyzing data from African American adults (18–85) in Southeastern Virginia (2016–2020), we found Mood Affective Disorders were most prevalent (41.66%), followed by Schizophrenia Spectrum and Other Psychotic Disorders. Females predominantly experienced mood disorders, with patient ages typically ranging from late thirties to mid-forties. Medicare coverage was notably high among schizophrenia patients, while emergency admissions and comorbidities significantly impacted total healthcare charges. Machine learning models, including gradient boosting, random forest, neural networks, logistic regression, and Naive Bayes, were validated through 100 repeated 5-fold cross-validations. …

Treatment Effects Of Genital Mycoplasma Species In High-Risk Pregnant Individuals: A Retrospective Cohort Study, Takashi Yoshimasu, Tasuku Inao, Tetsuya Kawakita

Department of Obstetrics & Gynecology Faculty Publications

Objective

We aimed to estimate the causal effect of treatment for genital Mycoplasma species on preterm birth (PTB) and spontaneous abortion (SA). We also evaluated treatment effects separately for cases with co-infection of Ureaplasma and Mycoplasma species.

Methods

This was a retrospective observational cohort study at a single center. Singleton mothers with one or more risk factors for PTBs were screened and treated for genital Mycoplasma species. The treatment was repeated based on polymerase chain reaction (PCR) results after each course. We applied inverse probability treatment weighting, and risk differences (RDs) of the treatment effect on pregnancy outcomes were estimated …

Automated Thermo-Mechanical Therapy For Immediate Relief In Chronic Non-Specific Lower Back Pain (Cnslbp): A Randomized Controlled Trial, Kyle V. Donnery

Dissertations and Theses

Objective: Chronic non-specific lower back pain (cNSLBP) is a prevalent and disabling condition, imposing a substantial socioeconomic burden due to high healthcare costs and productivity losses, with limited accessible and effective long-term treatment options. Automated Thermo-mechanical Therapy (ATT) is a promising, non-drug intervention that leverages innovative technical advances to provide multimodal pain relief, offering accessibility and low-cost delivery. This study tested ATT for immediate pain relief in individuals with cNSLBP in a single-session, double-blind, randomized controlled trial.

Methods: Forty participants with cNSLBP were randomly assigned to receive either active ATT (n=20) or control ATT (n=20) in a 40-minute session. The …

Training Set Augmentation And Harmonization Enables Radiomic Models To Detect Early Onset Of Lung Cancer, Claire Huchthausen, Menglin Shi, Gabriel L.A. Sousa, James Larner, Einsley Janowski, Jonathan Colen, Krishni Wijesooriya

Data Science Faculty Publications

Radiomics-based machine learning models have the potential to detect lung cancer at inception from CT scans and transform patient outcomes. Low malignancy rates in early-development pulmonary nodules (PNs) and variable image acquisition hinder development of clinically applicable radiomics-based early detection models. To address these challenges, we augmented training using later-development PNs and harmonized for acquisition effects. We first trained machine learning models to predict PN malignancy using radiomic features from scans of early-development benign and malignant PNs (n = 187) harmonized using ComBat. Observing near-chance performance, we augmented training with later-development benign and malignant PNs (n = 225). We evaluated …

Lis1 Depletion In Adult Mouse Projection Neurons Causes Neurodegeneration And Severe Neurological Phenotypes, Anne Ventrone

Theses and Dissertations

Proper LIS1 function is crucial for human brain development, as mutations in LIS1 lead to lissencephaly, a severe neurodevelopmental disorder caused by defective proliferation, differentiation and migration of neural precursors. Our understanding of LIS1's functions after brain development is limited. LIS1 regulates cytoplasmic dynein 1 (dynein), an essential microtubule motor protein in cell division and migration, but also a cellular transport motor. We previously showed that tamoxifen (TX)-induced global knockout of LIS1 using a Cre/Lox system (Act-Lis1iKO) in young adult mice results in severe neurological defects and rapid lethality. This strongly supports LIS1's critical post- developmental role, but the underlying …

Racial Disparities In Adherence To Diabetes Management Guidelines: The Impact Of Immigration Status Among Asian Populations In The U.S., Aliya Kuerban Phd, Fnp-Bc, Ms, Ma, Rn, Yuging Zhang

Nursing: Faculty Presentations

Background/Purpose

Asian populations in the U.S. demonstrate lower adherence to diabetes management guidelines compared to other racial groups. The American Diabetes Association (ADA) recommends a minimum of two annual A1C tests to manage diabetes effectively. This study examines racial disparities in adherence to these guidelines, focusing on the impact of immigration-related factors and patient perceptions of provider communication. The findings aim to identify barriers and inform strategies to enhance diabetes management and improve patient-provider interactions in underserved communities.

Theoretical/Conceptual Framework

This study employs a modified patient-provider communication model as its theoretical framework, emphasizing how effective communication can influence adherence to …

Intracellular Survival Of Staphylococcus Aureus In Macrophages During Osteomyelitis, William A. Lathram, Christopher D. Radka

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Staphylococcus aureus, traditionally viewed as an extracellular pathogen, is increasingly recognized for its ability to persist intracellularly, particularly within macrophages. This intracellular lifestyle is central to osteomyelitis, a chronic bone infection characterized by persistent inflammation, bone destruction, and impaired repair. Within bone, S. aureus exploits macrophage plasticity by driving a shift from pro-inflammatory, bactericidal M1-like states to anti-inflammatory, tissue-reparative M2-like phenotypes. This polarization suppresses immune clearance and promotes an environment conducive to bacterial survival and dissemination. Additional strategies – including biofilm formation, small colony variants, and inhibition of phagolysosomal killing – further enhance persistence and immune evasion. While these …

Serglycin Controls Megakaryocyte Retention Of Platelet Factor 4 And Influences Megakaryocyte Fate In Bone Marrow, Joshua Lykins, Isabelle C. Becker, Virginia Camacho, Hammodah Rawhi Hammodah Alfar, Joonwoo Park, Joseph Italiano, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Megakaryocytes (MKs) produce platelets, and similar to other hematopoietic progenitors, they are involved in homeostatic aspects of their bone marrow niche. MKs release and endocytose various factors, such as platelet factor 4 (PF4)/CXCL4. Here, we show that the intra-α-granular proteoglycan, serglycin (SRGN), plays a key role in this process by retaining PF4, and perhaps other factors, during MK maturation. Immature, SRGN–/– MKs released ~80% of their PF4, and conditioned media from these cells negatively affected wild-type MK differentiation in vitro. This was replicated in wild-type MKs by treatment with the polycation surfen, a known inhibitor of glycosaminoglycan (GAG)/protein interactions. In …

Abcg5/Abcg8-Independent Mechanisms Fail To Maintain Sterol Balance In Mice Fed A High-Cholesterol Diet, Garrett B. Anspach, Rupinder Kaur, Isha Chauhan, Erika L. Savage, Brittney Poole, Victoria P. Noffsinger, Xiaoming Fu, Zeneng Wang, Clairity Voy, Ryan E. Temel, Scott M. Gordon, Robert N. Helsley, Gregory A. Graf

Saha Cardiovascular Research Center Faculty Publications

The ABCG5/ABCG8 (G5G8) sterol transporter opposes the accumulation of dietary xenosterols but is also the primary mediator of biliary cholesterol secretion. In humans and in mouse models of disrupted biliary cholesterol secretion, fecal neutral sterols (FNSs) remain constant, indicating the presence of an alternate pathway for cholesterol excretion. Transintestinal cholesterol elimination or excretion (TICE) is thought to compensate for biliary disruptions and G5G8 insufficiency. We sought to measure the compensatory increase in intestinal cholesterol secretion and provide mechanistic insight for how TICE maintains sterol balance in the absence of hepatic G5G8. Differences were not observed in FNSs between control, acute, …

Sexual And Reproductive Health Access Among Racial/Ethnic Minority College Students, Srithanvi Pasunuri

Honors Undergraduate Theses

Sexual and reproductive health (SRH) is critical for individual well-being, yet significant disparities in access persist among racial and ethnic minority college students in the United States. These inequities, driven by systemic barriers such as financial constraints, cultural stigmas, and inadequate campus resources, contribute to higher rates of unintended pregnancies, sexually transmitted infections (STIs), and poor health outcomes within these populations. This systematic review aims to identify and synthesize existing literature on the barriers to SRH access for racial and ethnic minority college students, explore how cultural, social, and institutional factors influence service utilization, and assess interventions proven effective in …

The Association Between Pain Sensitivity And Low Energy Availability, Sleep, Mental Health, And Stress In Female Endurance Athletes, Taylor R. Moler

Honors Undergraduate Theses

The disruption of certain physiological functions due to low energy availability (LEA) in female endurance athletes is a prominent concern. This condition resulting from LEA has been described as Relative Energy Deficiency in Sport (RED-S), which can include alterations in metabolism, menstrual function, bone deposition and resorption, mental well-being, and more. The goal of this study was to determine whether pain sensitivity was associated with LEA, sleep, mental health, and stress in female endurance athletes. Participants completed a demographic survey, the Low Energy Availability in Females Questionnaire (LEAF-Q), the Pittsburgh Sleep Quality Index (PSQI), the Patient Health Questionnaire (PHQ-4), and …

Navigating The Intersections: Immigration, Diversity Of The Workforce, Precarious Work, And Vulnerabilities In Occupational Safety And Health, Daniel Côté, Jessica Dubé

Éditoriaux, lettres à l'éditeur

Dans un contexte de mondialisation croissante, la migration est une réalité incontournable qui expose les travailleurs migrants et autochtones à des conditions précaires et à des vulnérabilités accrues en matière de santé et sécurité du travail (SST). Les formes d’emploi précaires – contrats temporaires, travail à temps partiel ou informel – touchent de manière disproportionnée ces travailleurs, limitant leur accès aux droits et protections. Les travailleurs autochtones, particulièrement en milieu rural et dans des secteurs à risque, font face à des défis similaires en raison de marginalisations historiques et structurelles.

Ce texte présente les cinq articles de la section spéciale …

Role Of Online Health Information Resources In Shaping Self Confidence Of Nursing And Midwifery Students In The Digital Era At Aga Khan University, Tanzania, Getrude Ngowi, Jackline Estomihi Kiwelu

Book Chapters / Conference Papers

Digital technologies have transformed the way people learn in the current age. Innovative multimedia online nursing and midwifery information resources have improved nursing education and brought about adaptive, interactive, and collaborative learning. This study aims to find out whether the online nursing information resources provided at Aga Khan University Tanzania are shaping the self-confidence of nurses and midwives in the digital era, to understand gaps and areas for improvement. This study used both quantitative and qualitative research approach were used. The researchers collecting data using online Google Forms, which were analysed thematically through Atlas ti. The results revealed that persistent …