Medicine and Health Sciences Commons^™

The Ptp4a3 Inhibitor Kvx-053 Reduces Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Virulence, Inflammation, And Development Of Acute Lung Injury In K18-Hace2 Mice, Ruben M. L. Colunga-Biancatelli, Pavel A. Solopov, Caitlin M. Woodson, Irving Coy Allen, Ivan Akhrymuk, Maryna Akhrymuk, Brittany N. Heath, Hannah M. Ivester, Tierney Day, Dan E. Austin, Kylene Kehn-Hall, John S. Lazo, Elizabeth R. Sharlow, John D. Catravas

Bioelectrics Publications

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a global health crisis, marked by high transmissibility and virulence. Despite widespread vaccination efforts, effective treatments for COVID-19, particularly for severe cases leading to Acute Respiratory Distress Syndrome (ARDS), remain limited. This study investigates the efficacy of KVX-053, a protein tyrosine phosphatase type IVA (PTP4A3) small molecule inhibitor, in modulating SARS-CoV-2-induced inflammation and lung injury using in vitro cell models and in vivo K18-hACE2 transgenic mice. KVX-053 reduced in vitro pro-inflammatory cytokine expression, including TNFα, CXCL10, and CXCL11, without impacting viral replication or cell viability. K18-hACE2 mice treated with KVX-053 demonstrated …

Anabolic Properties Of The Progestin Altrenogest And Its Regulation As An Environmental Substance In Horse Racing – Review And Analysis, Andreas F. Lehner, Levent Dirikolu, Sarah Jacob, Kimberly Brewer, Abelardo Morales Briceñoe, Robert Holland, George Maylin, Clara Fenger, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Altrenogest is a progestogen substance used in equine medicine for the synchronization of ovulation during the spring breeding season and the control of estrus in mares. It accomplishes its actions by down-regulation of endometrial progesterone receptors and repression of estrogen receptor transcriptional activation. However, various groups have also measured androgen receptor binding activity for altrenogest in vitro; these findings combined with androgenic and anabolic properties roughly 1/20 in potency of testosterone and its structural similarity to the anabolic steroid trenbolone have created concerns among racing authorities of altrenogest’s potential abilities to alter the outcome of equine athletic performance, even though …

The Mediating Effect Of Injury On The Relationship Between Running Mileage And Depressive Symptoms In Division 2 Cross Country Athletes, Jaxon Leduc

Cal Poly Humboldt theses and projects

Training for a cross-country season requires athletes to accumulate a high volume of training miles at different intensities. Over a period of months and years, consistent high training volumes have been shown to contribute to overuse injuries in cross country athletes. Injuries have been shown to negatively impact athlete’s mental health; this is especially true in student athletes. The purpose of this research is to explore the mediating effect of injuries on the relationship between training volume and mental health in collegiate cross-country runners. Participants in this study were 40 members of NCAA Division 2 Cross Country teams with eligibility …

A Comparative Analysis Of Perineuronal Nets In Trout And Zebrafish Models, Adnan Alyan

Cal Poly Humboldt theses and projects

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround certain types of neurons in the central nervous system. Research from the past few decades has cemented PNNs as an integral player in the closure and onset of critical periods, memory modulation, and neural plasticity. These effects are thought to occur when PNNs form around a neuron and structurally stabilize its synaptic connections. PNNs have been directly linked to behavioral changes, making them of interest to psychologists as well as neuroscientists. Several PNN components, such as Hapln1 and aggrecan such as have been found in zebrafish, a teleost fish (Kang …

Tickborne Illness, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Animal Bites (Mammal), Children's Mercy Kansas City

Clinical Pathways

No abstract provided.

Utilizing A Virtual Discharge Nurse To Help Decrease Patient Length Of Stay And Improve Earlier Discharge Times, Carol A. Romano

West Chester University Doctoral Projects

Abstract

This Doctor of Nursing Practice (DNP) project explores the impact of implementing a Virtual Discharge Nurse (VDN) on patient length of stay (LOS) and discharge timing at Paoli Hospital within the Main Line Health system. Hospital discharges are often complex and can negatively impact patient flow and outcomes. This study highlights the urgent need for innovative discharge practices in healthcare and supports the potential benefits of integrating technology into nursing roles to improve patient care and operational efficiency. The project's significance lies in addressing these challenges by utilizing VDN to enhance communication, education, and resource management during discharge. We …

Cultivating Civility, Courtney Ruck

West Chester University Doctoral Projects

Nurse leaders play a vital role in creating, sustaining, and ensuring a culture of civility along with a healthy work environment for both staff and patients. A challenge nurse leaders face today is the prevalence of bullying and incivility that continues to grow within the nursing profession and has detrimental effects on nursing staff, patient satisfaction, and healthcare organizations. Bullying and incivility can have disastrous effects on the mental, emotional, physical, and professional lives of those victimized by such behavior. When a culture of incivility is prevalent, patients suffer as secondary victims; patient safety and patient satisfaction are compromised. Organizations …

Development Of An Artificial Intelligence Powered Software For Automated Analysis Of Skeletal Muscle Ultrasonography, Zoe Calulo Rivera, Felipe González-Seguel, Arimitsu Horikawa-Strakovsky, Catherine Granger, Aarti Sarwal, Sanjay Dhar, George Ntoumenopoulos, Jin Chen, V. K. Cody Bumgardner, Selina M. Parry, Kirby P. Mayer, Yuan Wen

Center for Muscle Biology Faculty Publications

Muscle ultrasound has high utility in clinical practice and research; however, the main challenges are the training and time required for manual analysis to achieve objective quantification of muscle size and quality. We aimed to develop and validate a software tool powered by artificial intelligence (AI) by measuring its consistency and comparability of expert manual analysis quantifying lower limb muscle ultrasound images. Quadriceps complex (QC) and tibialis anterior (TA) muscle images of healthy, intensive care unit, and/or lung cancer participants were captured with portable devices. Manual analyses of muscle size and quality were performed by experienced physiotherapists taking approximately 24 …

The Effect Of Fructose Metabolism On Hepatic De Novo Lipogenesis And Adipose Tissue Insulin Resistance, Taghreed Ibrahim Fadhul

Theses and Dissertations--Nutritional Sciences

There is a worldwide epidemic of obesity and metabolic dysfunction. The root cause of obesity is driven by a positive energy balance, which is a consequence of increased caloric intake and decreased energy expenditure. Energy intake is the more dominant force, as increasing energy expenditure is a time-consuming and labor-intensive process. The caloric surplus can be mainly accounted for by increased consumption of high-fat and high-sugar diets. While the risks associated with fat consumption are well-documented, the impact of sugar intake is less understood.

Fructose is a simple sugar widely consumed in modern diets. Its intake has been associated with …

Menstrual Hygiene Screening Needs Assessment In South Dakota, Mariah M. Shafer, Denyelle Kenyon

Scholarship Pathways Program

Introduction: Menstrual hygiene management (MHM) is essential to women’s reproductive health; literature demonstrates there are mental, social, and economic consequences to inadequate MHM in rural and developing countries. Emerging studies show that US women who are impoverished, experiencing homelessness, or incarcerated also face poor MHM. To understand the implications of poor MHM in South Dakota, a largely rural state, a thorough gynecologic health history is essential; this needs assessment explores the scope of MHM questions asked by SD providers.

Methods: This study used survey methodology to determine the quality and depth of gynecologic health histories commonly taken regarding hygiene. The …

Sharksrx Newsletter Spring 2025, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Factors And Outcomes Associated With Using Scratch‐Cooked, Organic, And Locally Grown Foods In School Meals In California, Monica D. Zuercher, Dania Orta-Aleman, Caitlin D. French, Juliana F.W. Cohen, Christina A. Hecht, Kenneth Hecht, Leah Elizabeth Chapman, Margaret Read, Punam Ohri-Vachaspati, Marlene B. Schwartz, Anish I. Patel, Lorrene D. Ritchie, Wendi Gosliner

Health Sciences Faculty Publications

No abstract provided.

Synthesis, Characterization, And Biological Activity Of Ni(Ii) And Co(Iii) Thiosemicarbazone Complexes As Potential Anticancer Agents, Jack Martin

Pitzer Senior Theses

The mechanics by which Reactive Oxygen Species work is an area of great interest given ROS’s wide range of biological applications. From cell signaling and mitochondrial regulation to pathogenesis and tumor cell death, varying concentrations of ROS in a system can lead to a whole host of positive and negative effects. In a similar vein, thiosemicarbazones are known to be equally useful for their myriad of antibacterial, antifungal, antiviral, and antitumoral effects. They have been at the core of the pharmaceutical world or the better part of the last century. The purpose of this work is to synthesize, characterize and …

Optimizing Decision-Making In A Cerebral Palsy Model Using Reinforcement Learning, Richard Ampah

Pitzer Senior Theses

This study presents an original interdisciplinary investigation into how reinforcement learning (RL) can model motor and cognitive defects and potentially improve motor and cognitive functions in individuals with cerebral palsy (CP), a non-progressive neurological disorder that impairs movement and adaptability. Integrating computational neuroscience and machine learning, the research applies policy gradient methods and Markov Decision Processes (MDPs) to simulate adaptive learning in agents with and without CP-related constraints.

The central aim is to compare the cumulative rewards of optimal policies, derived from value iteration, and human-like learning policies using the REINFORCE algorithm, both with and without the Bellman baseline. The …

Evaluation Of Corticosteroid Use In Pediatric Patients With Bronchiolitis, Kaitlyn Margraf Pharmd

Pharmacy Residency

Presented at Midyear Clinical Meeting.

Nearly 67% of pediatric patients treated for bronchiolitis received steroids with no underlying indication, which deviates from clinical guidelines. Patients who received steroids without an indication had an apparent trend toward more oxygen support and had an increase in maximum flow rate compared to patients with an indication for steroid use.

Use Of Finerenone For Chronic Kidney Disease In Type 2 Diabetes: A Cross-Sectional Study At A Large Health System, Robert D. Beckett

Parkview Pharmacy Department

Presented at the Midyear Clinical Meeting.

While most patients met individual KDIGO finerenone initiation criteria, fewer than one-third met all guideline recommended parameters. Guideline directed K+ monitoring following initiation was underperformed, highlighting a need for improved follow up Procedures.

Evaluation And Reduction Of Pediatric Precaution Alert Volume Across A Large Community Health System, Sarah Ferrell Pharmd

Parkview Pharmacy Department

Presented at the Midyear Clinical Meeting.

This evaluation found the potential to remove 15,174 alerts per year. Based off a physician spending a median of 8 seconds processing an alert, a reduction of 15,174 alerts per year saves about 34 hours of physician work-time per year.

Stool Rules: Evaluation Of Fidaxomicin Use Before And After Formulary Addition And Implementation Of Use Criteria, Anna Koeva Pharmd

Pharmacy Residency

Presented at the Midyear Clinical Meeting.

This evaluation found that appropriate use of fidaxomicin improved after addition to formulary with use restrictions, along with a decrease in 30-day CDI recurrence.

Naloxone Addition To The Nursing Admission Order Set: A Retrospective Review, Sydney Pelnick Pharmd

Pharmacy Residency

Presented at the Midyear Clinical Meeting

Nurse access to naloxone improved after implementation of standing order. Post-implementation outcomes demonstrated more appropriate use of naloxone. An increase in opioid utilization within 12 hours of naloxone supports a greater use for intended purpose.

Catch Flights, Not Rsv: Real-World Evaluation Of Respiratory Syncytial Virus (Rsv) Vaccine Use In Maternal And Older Adult Populations, Afamefuna Nzekwe

Pharmacy Residency

Present at the Midyear Clinical Meeting.

This evaluation found that most vaccinated patients met criteria. About 1/3 of newborns received RSV protection, but post-birth nirsevimab use could not be confirmed for non-Parkview patients.

Evaluating A Clinical Pharmacist's Role In An Internal Medicine Graduate Medical Education Primary Care Residency Clinic, Le Thien Truc Pham Pharmd

Pharmacy Residency

Presented at the Midyear Clinical Meeting

Approximately 98% of all survey participants were satisfied with the clinical pharmacy services. Diabetes management was found to be the most valuable pharmacy service.

Parent Social Media Use And Gaming On Mobile Phones, Technoference In Family Time, And Parenting Stress., Brandon Mcdaniel, Alison K. Ventura, Michelle Drouin

Health Services and Informatics Research

Possible effects of parent phone use on parent–child interactions and child behavior are of concern, warranting research to understand parent phone use. In this survey study of 183 families with a young child (M = 2.89 years), we examined parents’ phone use for texting/calling, social media (SM) use, mobile gaming (MG), and perceptions of cutting into family time; we also examined differences between mothers and fathers and associations with parenting stress. Mothers engaged in greater SM use but less MG compared to fathers; 61% of mothers and 38% of fathers used SM 31+ min per day, while 23% of …

The Anatomy Of A Reconstruction: From Fourier Space To Image Recovery In Computed Tomography, Charlotte P. Maurer

Honors Theses

This thesis develops the mathematical foundations of computed tomography (CT) reconstruction through the lens of harmonic analysis. Beginning with the Schwartz class, we introduce the Fourier transform and its role in expressing the Radon transform and its inversion via a fractional Laplacian. After constructing the Radon transform in general dimension R^d, we specialize to the cases d = 2 and d = 3, demonstrating explicit inversion formulas and the associated instability in lower dimensions. For its computational advantages, we study filtered back-projection using classical low-pass filters (Ram-Lak, Shepp–Logan, Cosine, Gaussian) and formulate a discrete reconstruction algorithm grounded in …

How Does Cocaine Exposure Affect Early Gene Expression Changes In The Prefrontal Cortex (Pfc) And Striatum?, Saathvika Diviti

Honors Theses

Cocaine use disorder (CUD) remains a significant public health concern, yet the molecular mechanisms underlying individual susceptibility are poorly understood. This study investigates early transcriptional responses to acute cocaine exposure in two key brain regions implicated in addiction, the prefrontal cortex (PFC) and striatum, using genetically diverse Diversity Outbred (DO) mice. Paired tissue samples were collected following a standardized sensitization protocol and analyzed via bulk RNA sequencing. Differential expression analysis revealed 37 significantly differentially expressed genes in the striatum. These genes overlapped with gene sets associated with substance use, neurodevelopmental disorders, and immune signaling, implicating shared pathways in central nervous …

Ai-Infused Discussion Boards: Enhancing Engagement, Reflection, And Academic Integrity In Anatomy And Physiology Education, Wade Dauberman

Teaching Repository of AI-Infused Learning

This paper presents the design, implementation, and evaluation of an AI-infused discussion board assignment that promotes ethical AI engagement, enhances student learning in anatomy and physiology, and addresses academic integrity concerns in higher education.

Mind The Gap, Klaire Perry

OTD 721: Cultural Responsiveness & Occupation

I went in to OT to make the world more accessible. I love how OT views people as their hopes, dreams, values, strengths, and facilitators...NOT as an injury or disease. At this point, every room I enter becomes a personal case study of accessibility. I can't help but wonder how many spaces have hung huge signs that say "YOU ARE NOT WELCOME" that are only visible to some. I'm thankful for my love ones who agreed to help me with this project. While I can never fully understand their experience, I can listen.

Klaire Perry, Class of 2027

Summer School: The Experience Of An Occupational Therapy Student Exploring Culture In Spokane!, Lulu Brady

OTD 721: Cultural Responsiveness & Occupation

This zine illustrates my experience in this OTD 721 Cultural Responsiveness class, led by Dr. Kirkpatrick. The class took place in the summer of 2025. It was absolutely inspiring, and I wanted to be able to share my takeaways and learnings from my experiences in this class. Culture is so relevant to the field of occupational therapy (OT) because occupations are often shaped by culture, OT cannot be truly client-centered without respective culture. Not only did this class help me grow as a future occupational therapist practitioner, but it also helped me grow as a person. It showed me the …

Welcomed In: A Love Letter To Okinawa, Taylor Fernandez

OTD 721: Cultural Responsiveness & Occupation

This zine is a personal, reflective project exploring Okinawan culture through my lens as a long-term guest -- first as a military child, then as an adult returning "home" to visit the island where my parents still live. While I am not Okinawan, the culture has deeply influenced my values, worldview, and understanding of community, aging, and wellness.

Through this project, I have sought to honor the richness of Okinawan traditions -- not as an authority, but a someone shaped by the grace of being welcomed in. The pages blend scholarly knowledge, lived experience, and cultural observation to explore how …

Occupational Apartheid, Kimberly Dewey

OTD 721: Cultural Responsiveness & Occupation

Occupational apartheid is a term that is often misunderstood. I wanted to bring more awareness and understanding to a very real concept that happens every day. I hope to have provided education and examples that make it easy to follow along and see how apartheid shows up on a daily basis. Let's work together as future OT professionals to expand our knowledge and practice to decrease experiences of occupational apartheid.

Kimberly Dewey, Class of 2027