Medicine and Health Sciences Commons^™

Standardizing Resident Teaching In Psychiatry: A Guide For Student Engagement, Faiza Ahmad, Lesley Chapa

MEDI 9331 Scholarly Activities Clinical Years

Residents play a crucial role in shaping medical students’ learning experiences and career decisions. However, interns enter residency with varying levels of teaching experience and may struggle to engage students while managing their clinical workload. This variability often leads to inconsistent educational experiences across rotations. In Psychiatry, students frequently find the Mental Status Examination (MSE) particularly challenging due to time constraints in clinical teaching, often resulting in a superficial understanding and rote documentation. As residents advance, their increasing clinical responsibilities and distance from Step 2/Shelf-relevant material can further limit their ability to provide effective teaching. This project aims to bridge …

Alcohol And Cannabis Use For Pain Management: Translational Findings Of Relative Risks, Benefits, And Interactions, Sumin Lee, Scott Edwards

School of Medicine Faculty Publications

Chronic pain affects over 20% of the global population and contributes to the vast burden of psychiatric illness. While effective treatments for chronic pain remain limited, both alcohol and cannabis have been used for centuries to manage pain and closely associated negative affective symptoms. However, persistent misuse of alcohol and/or cannabis in such a negative reinforcement fashion is hypothesized to increase the risk of severity of substance use disorders (SUDs). The current review describes neurobiological evidence for the analgesic efficacy of alcohol and primary cannabis constituents and how use or co-use of these substances may influence SUD risk.

Ccrl2 Promotes The Interferon-Γ Signaling Response In Myeloid Neoplasms With Erythroid Differentiation And Mutated Tp53, Pablo Toledano-Sanz, Joseph Rimando, Yashvi Hemani, Brandy Perkins, Xinghan Zeng, Conover Talbot, Bogdan Paun, Abdulmuez Abdulmalik, Chen Lossos, Tatianna R Boronina, Ilias Sinanidis, Panagiotis Tsakiroglou, Priyanka Fernandes, Christopher Esteb, Alexander J Ambinder, Robert N Cole, Rena Xian, Ivana Gojo, Suman Paul, Mark J Levis, Amy E Dezern, Leo Luznik, Styliani Karanika, Linda S Resar, Richard J Jones, Frederick Bunz, Lukasz Gondek, Marios Arvanitis, Theodoros Karantanos

Faculty, Staff and Students Publications

Patients with myeloid neoplasms with loss-of-function TP53 mutations and erythroid differentiation have poor outcomes, and a better understanding of disease biology is required. Upregulation of interferon-γ (IFN-γ) signaling has been associated with acute myeloid leukemia (AML) progression and chemotherapy resistance, but its drivers remain unclear. In this study, we found that the surface receptor C-C motif chemokine receptor-like 2 (CCRL2) is overexpressed in AML with erythroid differentiation and TP53 mutations compared to other AML subtypes and healthy hematopoietic cells. The knockout (KO) of CCRL2 suppressed erythroleukemia growth in vitro and in vivo . Further proteomics and transcriptomics analysis revealed IFN-γ …

Hollow Fiber-Based Strain Sensors With Desirable Modulus And Sensitivity At Effective Deformation For Dexterous Electroelastomer Cylindrical Actuator, Yang Zhang, Keqi Deng, Tingting Shen, Yong Huang, Zhenjin Xu, Jinhui Zhang, Hang Jin, Xin Liu, Lida Xu, Lianjie Lu, Shiying Li, Daoheng Sun, Dezhi Wu

Publications

The electroelastomer cylindrical actuators, a typical representation of soft actuators, have recently aroused increasing interest owing to their advantages in flexibility, deformability, and spatial utilization rate. Proprioception is crucial for controlling and monitoring the shape and position of these actuators. However, most existing flexible sensors have a modulus mismatch with the actuation unit, hindering the free movement of these actuators. Herein, a low-modulus strain sensor based on laser-induced cellular graphitic flakes (CGF) onto the surface of hollow TPU fibers (HTF) is present. Through the electrostatic self-assembly technology, the flexible sensor features a unique hybrid sensing unit including soft HTF as …

Kedrec-Lm: A Knowledge-Distilled Explainable Drug Recommendation Large Language Model, Yejin Kim, Fabricio Murai, Xiaozhong Liu

Faculty, Staff and Student Publications

Drug discovery is a critical task in biomedical natural language processing (NLP), yet explainable drug discovery remains underexplored. Meanwhile, large language models (LLMs) have shown remarkable abilities in natural language understanding and generation. Leveraging LLMs for explainable drug discovery has the potential to improve downstream tasks and real-world applications. In this study, we utilize open-source drug knowledge graphs, clinical trial data, and PubMed publications to construct a comprehensive dataset for the explainable drug discovery task, named \textbf{expRxRec}. Furthermore, we introduce \textbf{KEDRec-LM}, an instruction-tuned LLM which distills knowledge from rich medical knowledge corpus for drug recommendation and rationale generation. To encourage …

Factor Structure And Longitudinal Changes In Bilinguals’ Oral Narratives Production: Role Of Language Exposure, Language-Domain Proficiency, And Transfer, Joseph Hin Yan Lam, Molly Ann Leachman, Cecilia Del Carmen Perez, Amy S. Pratt, Elizabeth D. Peña, Lisa M. Bedore, Ronald B. Gillam

Communicative Disorders and Deaf Education Faculty Publications

This paper examined the interaction between narrative performance, language exposure, and standardized measures of morphosyntax and semantics, in bilingual children tested two times, 1 year apart. We aimed to 1) identify the factor structure of oral narrative measures, and 2) examine the direction and strength of the effects of (i) language exposure and (ii) the relationship between language domains and narrative production. A total of 143 Spanish (L1)-English (L2) bilingual children completed a battery of oral narrative and oral language proficiency assessments in Spanish and English at two time points (kindergarten and Grade 1). Factor analyses yielded an identical two-factor …

The Pulse - February 27, 2025, Unm Hsc Marketing & Communications

The Pulse

Weekly newsletter of the UNM Health Sciences Center.

Complement Activity And Autophagy Are Dysregulated In The Lungs Of Patients With Nonresolvable Covid-19 Requiring Lung Transplantation, Scott D Collum, Bindu Akkanti, Simon Yau, Howard J Huang, Rahat Hussain, Harry Karmouty-Quintana

Faculty, Staff and Student Publications

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19) pandemic has challenged the current understanding of the complement cascade mechanisms of host immune responses during infection-induced nonresolvable lung disease. While the complement system is involved in opsonization and phagocytosis of the invading pathogens, uncontrolled complement activation also leads to aberrant autophagic response and tissue damage. Our recent study revealed unique pathologic and fibrotic signature genes associated with epithelial bronchiolization in the lung tissues of patients with nonresolvable COVID-19 (NR-COVID-19) requiring lung transplantation. However, there is a knowledge gap if complement components are modulated to contribute to tissue …

Is The Pendulum Slowly Starting To Swing Back?, Michael S Ewer, Jay Herson

Faculty, Staff and Student Publications

No abstract provided.

The Transition To Adulthood: A Qualitative Study Of Autism Spectrum Disorder From Military And Veteran Parents And Military-Dependent Young Adults, Antonio F Pagán, Mara C Montenegro, Mark Ahlenius, Ana C Ramirez, Miriam Ortiz, Estefani Bernal, Cecilia Montiel-Nava, Jennifer Bittner, Katherine A Loveland, Ron E Acierno

Faculty, Staff and Student Publications

Introduction: Given the unique experiences of military service members and their families, military-dependent young adults (18-25 years old) with autism spectrum disorder (ASD) and their military or veteran families experience unique barriers to accessing quality mental health care during the transition to adulthood. In fact, developing services to address ASD challenges for military families is a burgeoning area of interest for the department of defense. However, there is a limited knowledge on the specific needs of military families as the young adult's transition outside of high school and lose supports.

Materials and methods: The present study conducted 3 focus groups …

Staff Education Project Staff Education To Encourage The Accurate Use The Dynamic Appraisal Of Situational Aggression In A U.S. State Psychiatric Facility, Tracy Ann Reid-Saunders

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project involved the development and implementation of a staff education program to enhance the use of the Dynamic Appraisal of Situational Aggression (DASA) tool. The aim of the project was to address the inconsistent and inaccurate applications of the DASA tool by health staff, leading to missed opportunities for early intervention to address patient aggression and increased risk of violence to both staff and patients. The importance of addressing this issue within the context of nursing practice rests on the DASA tool’s importance as a means for nurses to assess patients with aggressive behavior, …

More Than Numbers: Black Adolescents’ Journey With Type 1 Diabetes Management, Vanessa Di Felice

Walden Dissertations and Doctoral Studies

Black adolescents with Type 1 diabetes mellitus (T1DM) face significant health disparities, yet their unique treatment journeys remain largely underreported. This phenomenological qualitative study explored the lived experiences of Black adolescents with T1DM. The study addressed two research questions examining how these individuals experience and navigate T1DM self-management, self-efficacy beliefs, and perceived barriers and facilitators to optimal self-care. Virtual semi-structured interviews were conducted with 15 Black adolescents with T1DM recruited from a pediatric hospital in Washington, DC. The study utilized Bandura's social cognitive theory as the theoretical framework. Thematic data analysis identified four key themes: (1) character development through knowledge …

Nanometer Condensate Organization In Live Cells Derived From Partitioning Measurements, Archish Anand, Gandhar K Datar, Jeremy D Schmit, Joshua A Riback

Faculty, Staff and Students Publications

Biomolecules associate, forming condensates that house essential biochemical processes, including ribosome biogenesis. Unraveling how condensates shape macromolecular assembly and transport requires cellular measurements of nanoscale structure. Here, we determine the organization around and between specific proteins at nanometer resolution within condensates, deploying thermodynamic principles to interpret partitioning measurements of designed protein probes. When applied to the nucleolus as a proof of principle, the data reveals considerable inhomogeneity, deviating from that expected within a liquid-like phase. The inhomogeneity can be attributed to ribosome biogenesis, with the local meshwork weakening as biogenesis progresses, facilitating transport. Beyond introducing an innovative modality for biophysical …

Interim Estimates Of 2024-2025 Seasonal Influenza Vaccine Effectiveness - Four Vaccine Effectiveness Networks, United States, October 2024-February 2025, Haris M Ahmad, Ashley M Price, Wesley H Self, Yuwei Zhu, Basmah Safdar, Ithan D Peltan, Kevin W Gibbs, Matthew C Exline, Adam S Lauring, Sarah W Ball, Malini Desilva, Sara Y Tartof, Kristin Dascomb, Stephanie A Irving, Nicola P Klein, Brian E Dixon, Toan C Ong, Ivana A Vaughn, Stacey L House, Kiran A Faryar, Mary Patricia Nowalk, Manjusha Gaglani, Karen J Wernli, Vel Murugan, Olivia L Williams, Rangaraj Selvarangan, Geoffrey A Weinberg, Mary A Staat, Natasha B Halasa, Leila C Sahni, Marian G Michaels, Janet A Englund, Marie K Kirby, Diya Surie, Fatimah S Dawood, Benjamin R Clopper, Heidi L Moline, Ruth Link-Gelles, Amanda B Payne, Elizabeth Harker, Kristina Wielgosz, Zachary A Weber, Duck-Hye Yang, Nathaniel M Lewis, Jennifer Decuir, Samantha M Olson, Jessie R Chung, Brendan Flannery, Lisa A Grohskopf, Carrie Reed, Shikha Garg, Sascha Ellington, Cdc Influenza Vaccine Effectiveness Collaborators

Faculty, Staff and Students Publications

Annual influenza vaccination is recommended for all persons aged ≥6 months in the United States. Interim influenza vaccine effectiveness (VE) was calculated among patients with acute respiratory illness–associated outpatient visits and hospitalizations from four VE networks during the 2024–25 influenza season (October 2024–February 2025). Among children and adolescents aged <18 years, VE against any influenza was 32%, 59%, and 60% in the outpatient setting in three networks, and against influenza-associated hospitalization was 63% and 78% in two networks. Among adults aged ≥18 years, VE in the outpatient setting was 36% and 54% in two networks and was 41% and 55% against hospitalization in two networks. Preliminary estimates indicate that receipt of the 2024–2025 influenza vaccine reduced the likelihood of medically attended influenza and influenza-associated hospitalization. CDC recommends annual receipt of an age-appropriate influenza vaccine by all eligible persons aged ≥6 months as long as influenza viruses continue to circulate locally.

Early Introduction Of Simulation In Undergraduate Nursing: How To Improve The First Year Nursing Experience, Tori Furlong, Kayla Skeate, Sara Nylin

Day of Scholarship

In spring 2023, nursing faculty introduced a simulation experience in the sophomore Health Assessment course. This initiative aimed to enhance student learning outcomes and reduce anxiety related to clinical practice, based on current research which indicates early introduction to simulation has a positive impact on student anxiety in the clinical setting. The simulation served as a summative assessment, integrating key competencies such as patient data collection, therapeutic communication, vital signs assessment, and respiratory evaluation. Initial evaluation efforts are ongoing, with data collection extending into 2024 after adding a documentation element. Data from the 2023 pilot suggests that the simulation significantly …

Safe And Effective Team Communication: Utilizing Virtual Simulation To Apply Ipass And Isbarr, Bethany J. Gerdin, Laura Nugteren, Ann E. Holland Phd, Rn

Day of Scholarship

Research problem: Recognizing failure in communication and teamwork as leading causes of sentinel events in patient care, the Department of Health and Human Services (2023) recommends utilizing standard scripts such as ISBARR and the newly developed IPASS for effective team communication. Study Design: Due to limited opportunity for interdisciplinary communication in the clinical setting, course faculty designed an alternative clinical experience using virtual simulation (VSIM). Students complete a medical-surgical VSIM independently and then participate in a faculty-guided small group experience to discuss rationale. They collaboratively prepare an ISBARR communication between the nurse and provider for a patient need that occurs …

Evaluation Of Unique Care Coordination And Transition Management Clinical Module, Debbie Solomon, Ann E. Holland Phd, Rn

Day of Scholarship

A two-year curriculum evaluation was undertaken to guide development of a unique clinical curricular module focused on care coordination and transition management. The module, in place in the junior curriculum since 2015, had been modified through the years in response to changes in faculty, clinical partners, and department resources. The COVID-19 pandemic significantly limited student field experiences, requiring development of existing and new on-campus simulated learning experiences. Three analytic processes were used to evaluate how teaching methods and resource utilization contributed to student achievement of learning outcomes. The results led faculty to reinitiate field experiences in home care and hospice …

Patient Centered Care Coordination: The Impact Of A Non-Acute Care Clinical Curricular Module On Nursing Student Learning Outcomes, Ann Holland, Jone Tiffany, Kathy Tilton, Mccall Kleve

Day of Scholarship

Addition of Care Coordination module to nursing curriculum

Nurses’ Understanding Of Skin Cancer, Sun Protective Behaviors And Their Ability And Comfort Level In Teaching And Screening Patients, Victoria Siegel Edd, Cns, Rn, Veronica Feeg, Lincy Philip, Patti Eckardt

Faculty Research Day

Abstract

Background:

Health promotion and patient advocacy are part of nursing practice. Nurses are in an ideal position to educate and assess patients for skin cancer. Skin cancer has reached epidemic proportions and is the only cancer increasing in frequency.

Aims:

The purpose of this study was to explore nurses’ understanding of skin cancer, sun protective behaviors and their ability and comfort level in teaching and screening patients.

Methods:

This survey study was designed to evaluate nurses’ understanding of skin cancer, sun protective behaviors and their ability and comfort level in teaching and screening patients. Participants were nurses in practice …

Anterior Vocal Fold Scar., Arianne J Abreu, Omar Ramadan, Robert T Sataloff

Otolaryngology (ENT) Resident Research

No abstract available

Association Of Knee Osteoarthritis Treatment Types, Patient Characteristics, And Medical History With Subsequent Risk For Total Knee Arthroplasty: Data From A New Real-World Registry, Andrew L. Concoff, Jennifer H. Lin, Andrew I. Spitzer, Vinod Dasa, Adam Rivadeneyra, David Rogenmoser, Mitchell K. Ng, Mary Digiorgi, Stan Dysart, Joshua Urban, William M. Mihalko, Michael A. Mont

School of Medicine Faculty Publications

BACKGROUND: This article examines predictors of subsequent total knee arthroplasty (TKA) within 6 months of nonoperative intervention based on (1) patient demographics; (2) knee osteoarthritis (OA) severity; and (3) various nonoperative treatments (cryoneurolysis with superficial or deep genicular nerve block, intra-articular [IA] hyaluronic acid injections, nonsteroidal inflammatory drug injections, IA-corticosteroids injections, or IA-triamcinolone extended-release [IA-TA-ER] injections). METHODS: Patients who had unilateral knee OA and received nonoperative intervention were identified in the Innovations in Genicular Outcomes Research registry between September 2021 and February 2024, identifying 505 patients. Baseline patient demographics were tabulated by knee OA severity as graded by Kellgren-Lawrence (KL) …

Preparing Public Health Researchers To Interact With State-Level Legislators: Evaluation Of The Texas Research-To-Policy Collaboration Project Training, Tiffni Menendez, Amelia Roebuck, Shelby Flores-Thorpe, Yuzi Zhang, Kathleen Manuel, Christine Jovanovic, Alexandra Van Den Berg, J. Taylor Scott, D. Max Crowley, Elizabeth C. Long, Deanna M. Hoelscher

Health Services and Informatics Research

To implement evidence-based health policy, public health researchers need to be equipped with the necessary skills or knowledge to engage with policymakers effectively. The study aimed to evaluate the impact of the Texas Research-to-Policy Collaboration (TX RPC) training on public health professionals and to compare the effectiveness of different training delivery modes (in-person or web-based). In the study, 59 researchers received training to increase their capacity for interacting with legislators and completed pre- and post-training surveys assessing three scales: self-efficacy, knowledge, and training needs. To determine researchers’ pre- and post-training changes, we applied paired t tests. Two-sample t tests were …

Accelerating Earlier Access To Anti-Tnf-Α Agents With Biosimilar Medicines In The Management Of Inflammatory Bowel Disease, Gionata Fiorino, Ashwin Ananthakrishnan, Russell D Cohen, Raymond K Cross, Parakkal Deepak, Francis A Farraye, Jonas Halfvarson, A Hillary Steinhart

2020-Current year OA Pubs

Data indicate that earlier initiation of anti-tumor necrosis factor alpha (anti-TNF-α) biologic medicines may prevent progression to irreversible bowel damage and improve outcomes for patients with inflammatory bowel disease (IBD), particularly Crohn's disease. However, the high cost of such therapies may restrict access and prevent timely treatment of IBD. Biosimilar anti-TNF-α medicines may represent a valuable opportunity for cost savings and optimized patient outcomes by improving access to advanced therapies and allowing earlier anti-TNF-α treatment initiation. Biosimilar anti-TNF-α medicines have been shown to offer consistent therapeutic outcomes to their reference medicines, yet despite entering the IBD treatment armamentarium over 10 …

A Review Of Gut Failure As A Cause And Consequence Of Critical Illness, Danielle E. Soranno, Craig M. Coopersmith, Jessica F. Brinkworth, Faith N. F. Factora, Julia H. Muntean, Monty G. Mythen, Jacob Raphael, Andrew D. Shaw, Vidula Vachharajani, Jeannette S. Messer

Department of Anesthesiology Faculty Papers

In critical illness, all elements of gut function are perturbed. Dysbiosis develops as the gut microbial community loses taxonomic diversity and new virulence factors appear. Intestinal permeability increases, allowing for translocation of bacteria and/or bacterial products. Epithelial function is altered at a cellular level and homeostasis of the epithelial monolayer is compromised by increased intestinal epithelial cell death and decreased proliferation. Gut immunity is impaired with simultaneous activation of maladaptive pro- and anti-inflammatory signals leading to both tissue damage and susceptibility to infections. Additionally, splanchnic vasoconstriction leads to decreased blood flow with local ischemic changes. Together, these interrelated elements of …

Increasing Risk Of Postlung Transplant Hospitalizations For Infection: An Analysis Of Recent Trends, Shi Nan Feng, Armaan F. Akbar, Alice L. Zhou, Andrew Kalra, Sean Agbor-Enoh, Christian A. Merlo, Errol L. Bush

SKMC Student Presentations and Publications

BACKGROUND: Despite advancements in lung transplantation (LT), infection remains a major cause of morbidity and mortality following LT. We examined trends in hospitalizations for infection in the first year after LT.

METHODS: We identified adult LT recipients in the United States (March 1, 2018-March 9, 2023) using the Organ Procurement and Transplantation Network database. We categorized transplants into 3 eras to account for the Composite Allocation Score allocation policy change and coronavirus disease 2019: March 2018 to March 2020, March 2020 to March 2022, and March 2022 to March 9, 2023. One-year post-LT survival was compared using Kaplan-Meier survival analysis …

Design And Validation Of A Cross-Cultural Virtual Exchange Experience Among Bilingual Medical Students, John R. Vaile, Cierrah Doran, Arlene R. Maheu, Valentina Jaramillo, Daniela A. Perez-Chadid, Tomas Fernandez, Carissa Walkosak, Dinah Roll Velez, Sara Carolina Bedoya Osorio, Courtney Seebadri-White, Susan Truong, Dimitrios Papanagnou, Andres Fernandez, Rosemary Frasso

Department of Medicine Faculty Papers

Exposure to cross-cultural medical education is essential for professionals aiming to work in global health or serve diverse communities. However, traditional in-person exchange programs can be complex, costly, and restricted, particularly during times when travel is limited, such as during the COVID-19 pandemic. These challenges prompted us to explore novel approaches to support cross-cultural exchange programs. We designed, piloted, and evaluated a cross-cultural virtual exchange experience using case-based learning (CBL). Our study involved 14 bilingual medical students from the United States and Colombia who participated in four virtual CBL sessions. Following each session, participants engaged in guided discussions to reflect …

Developing Evaluation Metrics To Measure The Us National Institute Of Health Plans To Enhance Diverse Perspectives: A Protocol For A Consensus-Based Study, Yulia A Levites Strekalova, Sanjay Jain, Pinaki Sarder

2020-Current year OA Pubs

INTRODUCTION: The diversity of participating investigators representing diverse disciplines, career stages, stakeholder groups, regions and types of institutions is essential for the success of large-scale research programmes. In 2021, the National Institutes of Health introduced a requirement for some of its large grants to include a separate section that describes the project's plan for enhancing diverse perspectives (PEDPs). Our project aims to develop consensus-based PEDP evaluation metrics and instruments that can be systematically and sustainably collected across the projects.

METHODS AND ANALYSIS: Evaluation work is organised into three objectives. First, shared knowledge about PEDP infrastructures, activities and outcomes will be …

Sweet Lies: Influence Of Food Marketing On Childrens’ Health And The Need For Reform, Mollie M. Warrington

Honors Theses

Markedly, there is heavy marketing of unhealthy food to children. This has become a significant public health concern because of escalating rates of child obesity, which have long-term consequences for physical health and severe mental health repercussions, such as body image concerns and low self-esteem. This thesis explores how food marketing strategies, historically rooted in television ads and evolving through digital platforms, are linked to children's dietary choices and broader public health implications. It analyzes various manipulative tactics, such as digital advertising, influencer endorsement, and gamification, showing how companies take advantage of the cognitive vulnerabilities of children to propagate unhealthy …

Cold Snare Polypectomy In Pediatric Polyposis: A Multicenter Experience., Hunter J. Friesen, Thomas M. Attard, Andrew Y J Liman, Osamu W. Yasui, Catharine M. Walsh, Roberto Gugig, Monique T. Barakat

Manuscripts, Articles, Book Chapters and Other Papers

Background: Cold snare polypectomy (CSP) is a well-established and recommended technique in adult gastroenterology for the safe, efficient and complete removal of nonpedunculated lesions up to 10 mm, with piecemeal excision possible for larger lesions. However, the application of CSP in pediatric patients remains underexplored. This study summarizes a multicenter experience of CSP in pediatric polyposis patients, focusing on safety, efficacy and clinical outcomes. Methods: This retrospective study was conducted at two pediatric tertiary centers, encompassing patients aged 1 to 21 years with polyposis who underwent colonoscopy with CSP and hot snare polypectomy (HSP) between January 2022 and …

Inhibition Of Il-6 Trans-Signaling Promotes Post-Stroke Functional Recovery In A Sex And Dose-Dependent Manner, Anjali Chauhan

Faculty, Staff and Student Publications

Introduction: Elevated circulating IL-6 levels are associated with poorer outcomes after stroke, and increased serum IL-6 levels are linked to a higher risk of stroke. IL-6 binds to soluble IL-6 receptors (sIL-6R) and subsequently to ubiquitously expressed gp130, initiating proinflammatory trans-signaling. This study tested the hypothesis that inhibiting IL-6 trans-signaling by administering soluble (s) gp130 improves long-term functional outcomes in young mice after stroke.

Methods: Recombinant mouse gp130Fc chimera (sgp130) was administered one hour after middle cerebral artery occlusion (MCAO) followed by twice-weekly administration for 2 weeks in mice (8-15 weeks old). Behavioral assessments were done on days 7 and …