Medicine and Health Sciences Commons^™

Reduction Of Prostate Cancer Risk: Role Of Frequent Ejaculation-Associated Mechanisms., Mohamed Hassan, Thomas W. Flanagan, Abdulaziz M. Eshaq, Osama K. Altamimi, Hassan Altalag, Mohamed Alsharif, Nouf Alshammari, Tamadhir Alkhalidi, Abdelhadi Boulifa, Siraj M. El Jamal, Youssef Haikel, Mossad Megahed

School of Medicine Faculty Publications

Simple Summary: There is considerable evidence to suggest that frequent ejaculation reduces the risk of prostate cancer. The more frequently ejaculation occurs without risky sexual behavior, the lower the risk of prostate cancer. The mechanisms regulating the reduction in PCa risk associated with frequent ejaculations are attributed to the suppression of the sympathetic nervous system, resulting in a relief of tension and a slowing of the division of prostate epithelial cells. It is suggested that ejaculation frequency affects gene expression in prostate tissue and subsequently influences the susceptibility of the tissue to tumor formation, leading to a reduction in the …

Reducing Medical Waste, George M. Jeha, Stanislav N. Tolkachjov

School of Medicine Faculty Publications

No abstract provided.

Psychosocial Burden And Suicidality In Epilepsy: A Public Health Concern, Martha Sajatovic

Faculty Scholarship

The increased risk for psychosocial burden and suicidality in people with epilepsy compared to the general population is a well-established global public health concern. Suicidality risk is also increased in patients with functional seizures. The timely identification of patients at highest risk for psychosocial burden and self-harm is vital. This can pose a significant challenge for multidisciplinary clinicians caring for people with epilepsy. Early identification of social stressors and comorbid psychiatric contributors via screening are required to assist with the development of predictive models for self-harm in epilepsy; and subsequent options for treatment and the provision of adjunct supports in …

The Spread Of Tuberculosis Cases In The Highlands And Coastal Areas Of Padang, Rapitos Sidiq, Indang Dewata, Heldi Heldi, Nurhasan Syah, Linda Handayuni, Al Asyary

Kesmas

The current tuberculosis (TB) worldwide situation is very concerning in terms of the number of cases and the death toll, as well as the environmental factors that contribute to its transmission. This has driven policy decisions that aim to enhance contemporary TB control efforts. This study aimed to map the pattern of TB spread based on geographic location, particularly in the highland and coastal areas of Padang City, West Sumatra Province, Indonesia. This study employed a quantitative descriptive analysis using secondary data from 6 primary health care (PHC) from April 2022 to March 2023, comprising 896 cases. Data analysis was …

Characteristic And Survival Analysis Of Infants With Critical Congenital Heart Disease, Suprohaita Rusdi Talib, Johanes Edy Siswanto, Mulyadi M. Djer, Nurzalia Safanta, Syifa Nurhakiki, Khobir Abdul Karim Taufiqurahman, Asri Adisasmita

Kesmas

Congenital heart disease (CHD) is a major health concern worldwide. This study focused on survival analysis and the factors influencing survival in infants with critical congenital heart disease (CCHD). A total of 79 infants diagnosed with CCHD were identified, with 48.1% (n=38) exhibiting duct-dependent pulmonary circulation, 35.6% (n=28) exhibiting duct-dependent systemic circulation, 6.3% (n=5) exhibiting critical non-duct-dependent, and 10.2% (n=8) exhibiting parallel circulation issues. Of the infants studied, 55.7% (n=44) were male, 78.5% (n=62) had a gestational age of ≥37 weeks, 62% (n=49) had a birth weight of ≥2,500 grams, 59.5% (n=47) exhibited normal fetal growth, 93.7% (n=74) experienced no …

Adolescent Reproductive Health Promotion For Senior High School Students, Niken Meilani, Sunarru Samsi Hariadi, Fransiskus Trisakti Haryadi

Kesmas

Adolescence is a vulnerable period to reproductive health problems, especially regarding issues of sexuality. Healthy adolescent behavior is needed to achieve the SDGs targets by 2030. This study aimed to analyze personal factors such as attitudes, perceptions, and self-efficacy, as well as environmental factors like family, school, friends, community, and social media's role in adolescent reproductive health behavior and health promotion models. This quantitative analysis was conducted using the survey method with 326 respondents at 32 senior high schools, involving 159 male and 167 female adolescents, as samples taken through a multistage random sampling technique. This study used a questionnaire …

Prevalence Of Low Back Pain Among Office Workers During The Covid-19 Pandemic In Various Countries: A Systematic Review, Yosephine Roma Intan, Ririn Arminsih Wulandari, Popy Yuniar

Kesmas

The COVID-19 pandemic has led to the implementation of work from home policies in almost all parts of the world. This policy has increased the onset of musculoskeletal disorders in workers, such as low back pain (LBP). This study aimed to examine the prevalence of LBP among office workers during the COVID-19 pandemic after implementing WFH policies. This study was performed using data from various countries to determine the relationship between LBP and several risk factors, specifically age, sex, physical activity, ergonomic factors, as well as work environment factors such as temperature, humidity, lighting, noise, and work duration. A systematic …

Thai Sugar-Sweetened Beverage Tax: Does It Really Help?, Sitaporn Suriya, Buraskorn Torut

Kesmas

A solution recommended by the World Health Organization to prevent and control noncommunicable diseases is the Sugar-Sweetened Beverage (SSB) tax. This study aimed to evaluate the Thai SSB tax efficiency affecting the change in post-tax individual-level consumption and find causal explanations for the people’s consumption behavior after the SSB tax was implemented. This study used a Productivity Model, and stratified random sampling was conducted by selecting 1,200 people. An in-depth interview was conducted to seek causal explanations for post-SSB tax consumption behavior with 15 key informants. The results revealed the SSB tax’s efficiency in terms of perception and understanding at …

Exploring Physician Well-Being: A Bibliometric Analysis Of Mental Health, Suriya Kumareswaran, Bala Murali Sundram, Vanitha Thurairasu

Kesmas

This bibliometric study examined the evolving research landscape on physician mental health from 2010 to 2023, analyzing key themes, publication trends, and global contributions. A total of 3,360 articles, including 3,137 original research and 223 reviews, were sourced from Web of Science and Scopus. Findings revealed a significant increase in research output, particularly during the COVID-19 pandemic, with burnout, depression, and anxiety emerging as dominant themes. The US accounted for most publications, while research from low- and middle-income countries remains limited, indicating a substantial global disparity. Thematic analysis highlighted variations in burnout assessment methodologies, underscoring the need for standardized evaluation …

Five-Year Journey Of Technical Assistance In Health Governance Reforms: A Case Report, Popy Yuniar, Indang Trihandini, Ibnu Muyassar, Latifatul Khoiriyah, Minawati Minawati, Fathiyya Aliyah Birjaman, Tyra Septi Diana, Annabel Serafina, Hertina Raisa Putri, Rana Maimunah, Riko Setiawan, Nadazaira Alifia Ramadhianisa, Aris Diyanto

Kesmas

Many districts and cities in Indonesia continue to have Public Health Development Index scores below the national average, highlighting the need for improved health governance. This study assessed the five-year impact (2019–2023) of a mentoring program for 149 District Health Offices in preparing annual work plans, focusing on stagnation or performance declines. Using a qualitative approach, the study analyzed annual work plan scores before and after technical assistance, conducted focus group discussions, and carried out in-depth interviews to identify challenges. Key barriers included data management issues, weak advocacy, knowledge transfer gaps, and poor cross-sectoral coordination, which hindered decision-making and program …

Public Health Entrepreneurship In Indonesia: What Is Next?, Hadi Pratomo, Roy Darmawan, Karina Samaria

Kesmas

Public health has been demanded to search for ways to improve well-being by tackling societal and ecological factors that influence health through cooperative strategies and partnerships across various fields. More interdisciplinary, interprofessional, and action-oriented approaches toward sustainable public health programs are recommended to be made. Therefore, public health entrepreneurship is an indispensable approach to creating new interventions that address future public health problems. The Indonesian Ministry of Health conceptualized five public health entrepreneurship skills as standard competence for public health personnel. In addition, the Association of Indonesian Public Health Higher Education Institutions has identified several study materials and learning outcomes …

Help-Seeking Behavior And Related Mental Health Promotion Programs In Southeast Asian Youth: A Systematic Literature Review, Gladys Octavia, James A. Doorbar, Kallista Chan

Kesmas

Mental health issues are a prominent burden among adolescents and young adults in Southeast Asia, compounded by reluctance to seek help and low treatment rates. This mixed-method systematic review analyzed help-seeking profiles (preference, facilitators, and barriers) and evaluated implemented help-seeking programs. Data were sourced from electronic databases, hand-searched local databases, conference proceedings, and grey literature. Study selection followed PRISMA 2020 guidelines, focusing on 1) adolescents (10–19 years) and young adults (18–26 years) in Southeast Asia who were not receiving mental health care, 2) assessing help-seeking behavior, and 3) evaluating programs to increase help-seeking. A total of 16 articles were identified. …

Norovirus Co-Opts Ninj1 For Selective Protein Secretion, Jaewon Song, Wandy L Beatty, Anthony Orvedahl, Et Al.

2020-Current year OA Pubs

Plasma membrane rupture by Ninjurin-1 (NINJ1) executes programmed cell death, releasing large cellular damage-associated molecular patterns (DAMPs). However, the regulation and selectivity of NINJ1-mediated DAMP release remain unexplored. Here, we uncover that murine norovirus (MNoV) strategically co-opts NINJ1 to selectively release the intracellular viral protein NS1, while NINJ1-mediated plasma membrane rupture simultaneously bulk-releases various cellular DAMPs. Host caspase-3 cleaves the precursor NS1/2, leading to NS1 secretion via an unconventional pathway. An unbiased CRISPR screen identifies NINJ1 as an essential factor for NS1 secretion. During infection, NINJ1 is recruited to the viral replication site, where it oligomerizes and forms speckled bodies, …

Families' Experiences Of End-Of-Life Care In An Acute Private Hospital: A Qualitative Study, Rosemary Saunders, Susan Alexander, Julie Andrew, Anne Wilkinson, Karen Gullick, Ashwini Davray, Manonita Ghosh, Karla Seaman, Michelle Gay

Research outputs 2022 to 2026

Objectives This study explored bereaved relatives' experiences of end-of-life care (EoL care) in the last 3 days in an acute private hospital in Australia. Methods An interpretative qualitative study was conducted. Semi-structured interviews with 8 bereaved relatives whose family member had died at an acute private hospital shared their experiences of the EoL care during the last 3 days of life. The transcribed interviews were analyzed using inductive thematic analysis. Results Bereaved family members had mixed experiences, and their primary concerns related to the need for improvements in support for the family; communication; and clinicians partnering with families. The need …

Androgen Receptor Ubiquitination Links Kctd13 To Genitourinary Tract Defects, Neetu Neetu, Abhishek Seth

Faculty, Staff and Students Publications

The potassium channel tetramerization domain containing 13 (KCTD13) protein is a substrate-specific adapter for cullin3-based E3 ubiquitin ligase. Patients with copy number variants at this locus exhibit genitourinary tract anomalies. In this study, we show that decreased androgen receptor (AR) protein level correlated with increased AR ubiquitination in the testis of Kctd13-deficient mice, suggesting that KCTD13 inhibits AR ubiquitination. KCTD13 increased CUL3-dependent AR ubiquitination but had no effect on CUL3 binding to AR, confirming the role of KCTD13 as an adaptor of CUL3 ligase. Recombinant KCTD13 directly binds to recombinant AR, and the BTB domain of KCTD13 is critical for …

Socio-Epidemiological Perspectives Of Sexual Trauma Experiences And Influential Factors On Sexual Orientation In Men Who Have Sex With Men, Rico Januar Sitorus, Misnaniarti Misnaniarti, Legiran Legiran, Rizma Adlia Syakurah, Diana Dewi Sartika, Asri Maharani, Retta Patresia

Kesmas

The complexity of sexuality and sexual trauma experiences, including harassment, unwanted touching, sexual urges, and forced sexual intercourse, should not be underestimated because of the tendency to initiate adverse psychosocial impacts. Sexual harassment can increase mental health risks, which may influence sexual orientation decisions. This quantitative study, using a cross-sectional design, aimed to determine a relationship between sexual trauma experiences and sexual orientation in men who have sex with men (MSM). This study population was MSM living in Palembang and Prabumulih City, with a sample size of 216 respondents. The proportion of respondents with homosexual orientation was 57.1%, and the …

Determinants Of Adolescent Resilience Levels In Surabaya City, East Java Province, Indonesia, Riris Diana Rachmayanti, Fatwa Sari Tetra Dewi, Diana Setiyawati, M Dody Izhar, Andrei Ramani

Kesmas

Assessing adolescent resilience may provide valuable insights into adult resilience. This study aimed to analyze the relationship between determinants and adolescent resilience in Surabaya City. The participants of this cross-sectional study were 277 adolescents aged 12–19 years who were in senior high school. The outcome was the resilience levels. This study's findings indicated relationships between resilience levels and stress experience (p-value = 0.01), access to mental health information (p-value = 0.00), life satisfaction (p-value = 0.00), family harmony (p-value = 0.03), presence of adults to share (p-value = 0.04), feeling safe at home, school, and community (p-value = 0.00), perception …

Dissolution Of Bovine Palatal Tissue With Degassed Sodium Hypochlorite

Faculty, Staff and Student Publications

Objective: To investigate the tissue dissolution efficacy of different concentrations of sodium hypochlorite (NaOCl) using the GentleWave® technology (GW) and compare it with that of passive ultrasonic irrigation. This study will provide a novel in vitro model used to evaluate the tissue dissolution efficacy of different concentrations of NaOCl using the GentleWave® procedure.

Materials and Methods: Palatal bovine tissue was standardized by weight at 70-75 mg (average of 74.4 mg). The samples were divided into three groups of n = 10, Group 1: GW + 0.5% NaOCl, Group 2: GW + 3% NaOCl, and Group 3: ultrasonic group (US) + …

Myelin-Reactive Cd8+ T Cells Influence Conventional Dendritic Cell Subsets Towards A Mature And Regulatory Phenotype In Experimental Autoimmune Encephalomyelitis, Mohit Upadhye, Connor R Wilhelm, Kai J Rogers, Chakrapani Vemulawada, Nicholas Borcherding, Alexander W Boyden, Kevin L Legge, Nitin J Karandikar

2020-Current year OA Pubs

Multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system, is modeled in mice as experimental autoimmune encephalomyelitis (EAE). While CD4

The Clinical Impact Of A Standardized Pathway For Chest Pain Evaluation In The Urgent Care Setting, Tysheena L. Jones

Doctoral Dissertations and Projects

This study aimed to evaluate the deficiencies in the current chest pain evaluation practices compared to standard of practice at urgent care centers and to develop an evidence-based clinical workflow prioritizing the reduction of the door-to-EKG times utilizing the Marburg heart score assessment tool. Conducted in three urgent care centers within a larger not-for-profit healthcare system, the retrospective pretest-posttest design involved 44 patients presenting with chest pain. Utilizing t-tests, the study found a significant reduction in door-to-EKG times from 39 minutes pre-intervention to 14 minutes post-intervention (p < 0.05). The pre implementation chart reviews revealed that 7 (32%) of the charts had the required risk assessment tool used, and score documented in the EMR. The post implementation chart reviews revealed that 6 (27%) of the charts had the required risk assessment tool used and score for chest pain documented in the EMR. The Marburg Heart Score facilitated timely identification of high-risk patients while minimizing unnecessary EKGs for low-risk individuals, though protocol adherence and external workflow disruptions were noted limitations. The findings underscore the importance of standardized workflows in enhancing care efficiency and patient outcomes, suggesting that future research explore long-term sustainability and broader implementation in urgent care settings.

Echocardiography And Heart Failure: An Echocardiographic Decision Aid For The Diagnosis And Management Of Cardiomyopathies., Ashley Pender, Jessica Lewis-Owona, Abdulmojeed Ekiyoyo, Marcus Stoddard

Division of Cardiology Faculty Papers

PURPOSE OF REVIEW: The purpose of this review is to highlight the utility of echocardiography in the diagnosis and management of cardiomyopathies.

RECENT FINDINGS: Echocardiographic parameters function synergistically to guide decision-making ranging from early detection of disease and screening to risk stratification of complex disease. The collective wealth of information available from 2D/3D assessment, Doppler, diastology and strain makes echocardiography an invaluable decision aid.

A Nursing Education Intervention In An Adult Inpatient Setting To Improve Compliance Rate With Pressure Injury Prevention Intervention, Brooklynn Jane Janke

Doctoral Dissertations and Projects

Pressure injuries can lead to life-threatening health complications for patients and cause physical, psychological, and financial stress to patients suffering from them. The literature review demonstrated that bedside nursing staff often have not received the appropriate education about pressure injury prevention and care. The literature review also revealed that nurses prefer to be educated one-on-one and peer-to-peer. Therefore, providing focused and frequent education on pressure injury prevention and improving nurses’ understanding of the importance of pressure injury prevention can improve the quality of care a nurse provides, and patients receive, thus reducing the number of health care-acquired pressure injuries. The …

Reducing Burnout Among Physiatry Trainees During The Pandemic: Instituting A Wellness Retreat, Edwin Amirianfar, Oliver Acosta, Eduard Tiozzo, Joslyn Gober, Monica Verduzco-Gutierrez

Journal of Wellness

Introduction: Burnout has been described as “a state of mental and physical exhaustion related to work or caregiving activities.” Among resident physicians, burnout is a serious concern that can lead to medical errors and negative patient outcomes. To combat burnout among physiatry trainees during the COVID-19 pandemic, an innovative wellness retreat was created and implemented at the University of Miami’s Physical Medicine and Rehabilitation (PM&R) Residency Program in March 2021 and February 2022.

Methods: The retreat curriculum was designed by the PM&R Residency Wellness Committee and supported by departmental funding. The retreat(s) consisted of three strategies: education and discussion on …

Development Of A Futsal Sports Curriculum Model Aged 6-8 Years At The Super Junior Club In Malang City, Dwi Novenda, Prisca Widiawati

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: The lack of a structured futsal curriculum for children aged 6-8 years in futsal clubs, especially in Super Junior Club Malang, causes limitations in developing techniques, skills, and long-term athlete development. Objective: This is for developing a futsal curriculum model at the Super Junior Club of Malang City, which is presented as a curriculum for learning. Methods: The research and development model used in the study is to develop a curriculum model. Development research This uses the ADDIE method with steps study as follows: 1) analysis, 2) design, 3) development, 4) implementation, and 5) evaluation. This is done using …

The Synergistic Effects Of Circuit Training And Diet On Weight Loss, Body Fat Percentage, And Bmi In Obese Indonesian Females: A Randomized Controlled Trial, Ali Muthahhari Rahim, Ahmad Nasrulloh

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: Despite the popularity of circuit training and dietary interventions, their combined effects on obese Southeast Asian populations remain underexplored.  Objective: This study aims to examine the effects of circuit training (using free weights and body weight) and dietary interventions (low-calorie diet and intermittent fasting using the OCD method), as well as their interaction, on weight loss, body fat percentage, and body mass index in obese individuals. Methods: This type of research is an experiment using a 2 x 2 factorial design. This experimental study used four groups that received different treatments, namely the provision of circuit training with free …

The Effects Of Competitive Plyometric Training On Speed, Strength, And Defensive Skills Of Handball Players, Abbas Abdulhamza Kadhem

Indonesian Journal of Research in Physical Education, Sport, and Health

Background: The importance of this research lies in preparing handball players with enhanced physical and skill capabilities through modern methods such as competitive plyometric training. The study was motivated by observed performance inconsistencies among Iraqi handball teams, particularly a decline in players' physical and technical execution toward the end of matches. This issue is attributed to the use of traditional training programs, which fail to develop the players’ physical fitness and technical performance adequately.  Objective: This study examines the effects of competitive plyometric training on handball players' speed, strength, and defensive skills. Methods: The research was driven by the observation …

Muscle-Specific Errγ Activation Mitigates Muscle Atrophy After Acl Injury, Aiping Lu, Katie J Sikes, Ping Guo, Matthieu Huard, Shelbi Green, Jacob Singer, Scott Tashman, Vihang A Narkar, Johnny Huard

Faculty, Staff and Student Publications

Anterior cruciate ligament (ACL) injury adversely affects skeletal muscle, leading to muscle atrophy and weakness, significantly impacting clinical outcomes. This study aimed to determine if estrogen-related receptor gamma (ERRγ) overexpression in skeletal muscle could mitigate muscle atrophy after ACL injury. An animal model with selective overexpression of ERRγ in skeletal muscle (ERR-gamma transgenic mice, TG) and WT control mice were used for this study. All the mice received a mechanical ACL rupture and were euthanized at 4- and 8-week post-injury. Muscle histology, atrophy, and function were evaluated and compared between the TG and WT mice. Muscle-specific ERRγ activation in TG …

New Onset Diabetes Predicts Clinical Outcomes In Patients With Pancreatic Adenocarcinoma, Chirayu Mohindroo, Paul S Dy, Suraj P Hande, Christopher R D'Adamo, Arun Mavanur, Florencia Mcallister

Faculty, Staff and Student Publications

Background: One percent of pancreatic adenocarcinoma (PDAC) patients are diagnosed with new onset diabetes (NOD) over the age of 50 years within 3 years. Therefore, NOD is a major factor for early diagnosis of PDAC. Research has focused on understanding the differences between NOD and type 2 diabetes, particularly in relation to PDAC. However, conflicting data exists regarding their impact on survival outcomes in PDAC patients. We performed this multi-center study to assess the prevalence and influence of NOD on clinical outcomes in patients with PDAC within a community-based hospital system.

Methods: We conducted a retrospective cohort study of 138 …

Chemogenetic Activation Of Microglial Gi Signaling Decreases Microglial Surveillance And Impairs Neuronal Synchronization, Yue Liang

Faculty, Staff and Student Publications

Microglia actively survey the brain and dynamically interact with neurons to maintain brain homeostasis. Microglial Gi protein-coupled receptors (Gi-GPCRs) play a critical role in microglia-neuron communications. However, the impact of temporally activating microglial Gi signaling on microglial dynamics and neuronal activity in the homeostatic brain remains largely unknown. In this study, we used Gi-based designer receptors exclusively activated by designer drugs (Gi-DREADD) to selectively and temporally modulate microglial Gi signaling pathway. By integrating this chemogenetic approach with in vivo two-photon imaging, we observed that exogenous activation of microglial Gi signaling transiently inhibited microglial process dynamics, reduced neuronal activity, and impaired …

Spetzler-Martin Grade I And Ii Cerebral Arteriovenous Malformations: A Propensity-Score Matched Analysis Of Resection And Stereotactic Radiosurgery In Adult Patients, Nimer Adeeb, Basel Musmar, Kareem El Naamani, Christopher Ogilvy, Douglas Kondziolka, Ahmed Abdelsalam, Deepak Kumbhare, Sanjeev Gummadi, Cagdas Ataoglu, Ufuk Erginoglu, Muhammed Amir Essibayi, Abdullah Keles, Sandeep Muram, Daniel Sconzo, Howard Riina, Arwin Rezai, Johannes Pöppe, Rajeev D Sen, Omar Alwakaa, Christoph J Griessenauer, Pascal Jabbour, Stavropoula I Tjoumakaris, Jan-Karl Burkhardt, Robert M Starke, Mustafa Baskaya, Laligam N Sekhar, Michael R Levitt, David J Altschul, Neil Haranhalli, Malia Mcavoy, Assala Aslan, Abdallah Abushehab, Christian Swaid, Adib Abla, Christopher Stapleton, Matthew Koch, Visish M Srinivasan, Peng R Chen, Spiros Blackburn, Mark J Dannenbaum, Omar Choudhri, Bryan Pukenas, Darren Orbach, Edward Smith, Markus Möhlenbruch, Ali Alaraj, Ali Aziz-Sultan, Aman B Patel, Hugo H Cuellar, Michael Lawton, Jacques Morcos, Bharat Guthikonda, Jason Sheehan

Faculty, Staff and Student Publications

Cerebral arteriovenous malformations (AVMs) are congenital vascular anomalies that can lead to severe complications, including hemorrhage and neurological deficits. This study compares the outcomes of microsurgical resection and stereotactic radiosurgery (SRS) for SM grade I and II AVMs. Out of a large multicenter registry, we identified 180 matched patients with SM grade I and II AVMs treated with either microsurgical resection or SRS between 2010 and 2023. The primary outcomes were AVM obliteration rates and complications; secondary outcomes included neurological status and functional outcomes measured by the modified Rankin Scale (mRS). Propensity score matching (PSM) was utilized to ensure comparability …