Medicine and Health Sciences Commons^™

Modified Shuttle Walk Test In Chronic Health Conditions: A Literature Review, Manish Prannath Shukla, Gaurav Chhabra, Ashish Shankarrao Deshmukh Dr

Internet Journal of Allied Health Sciences and Practice

Background: The Modified Shuttle Walk Test (MSWT) is widely utilized to assess exercise capacity across various chronic health conditions. This literature review synthesizes evidence from studies evaluating the MSWT's reliability, validity, and clinical applicability in conditions such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, sarcoidosis, obesity, hypertension, and asthma. Methods: A systematic search was conducted across electronic databases for studies published between 2006 and 2022. Eligible studies were assessed using Joanna Briggs Institute (JBI) critical appraisal tools. Data extraction focused on study objectives, methods, participants, outcomes, and quality assessment. Results: Eleven studies met the inclusion criteria. The MSWT demonstrated …

Awareness Of Predatory Journals Among Physiotherapist In Nigeria: A Result Of An Online Cross-Sectional Survey, Daha Garba Muhammad, Hassan Yusif Ahmad, Saadatu Abubakar Maiwada

Internet Journal of Allied Health Sciences and Practice

Objective: The open access publication has made it easier for low-quality journals to take advantage of new authors and those from developing countries. Therefore, this study is set to determine Nigerian Physiotherapist awareness of predatory journals (PJs).

Methodology: For this study, an online survey was used, and participants were recruited through a Google form shared via email and social media platforms like Facebook, WhatsApp, Instagram, and Twitter. The data was analyzed using frequency and percentage, and a chi-square test was used to see if there was a connection between demographic factors and awareness of predatory journals.

Results: …

High School Sport Specialization Associated With Missing Time With Friends And Frequent Travel, Madison N. Renner, Kevin M. Biese, Eric G. Post, Mayrena I. Hernandez, Emily C. Srygler, Stephanie N. Adler, David R. Bell

Internet Journal of Allied Health Sciences and Practice

Purpose: Physical consequences of youth sport specialization have been established, yet the psychosocial demands remain largely unexplored. Hypothesis: Missing time with friends due to sport demands and frequent out-of-state travel is associated with sport specialization classification for each high school grade, and this association remains after stratifying for gender and sport level. Study Design: Cross-sectional. Methods: Six hundred sixty-eight (349 female) Division I and club sport athletes from a large midwestern university completed a retrospective survey assessing sport specialization classification and the travel and social demands of sport participation for each high school grade. To measure the social and travel …

Impact Of An Education Session On Improving Female Collegiate Athletes’ Comfort With Women’S Health Topics, Pauline Skowron, Ramandeep Kaur, S. Andrew Cage, Carly Wadle, Laurel Trail, Lynzi K. Warner, Brandon J. Warner

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to assess the effectiveness of a face-to-face education session on women’s health topics to improve comfort among college female athletes when discussing women’s health topics with coaches, athletic trainers, and primary care physicians. A secondary purpose was to assess the effectiveness of the education session on college female athletes’ perceived knowledge of topics related to women’s health. Methods: A total of 44 female collegiate student athletes competing at an NCAA Division II institution consented to and participated in this study as a convenience sample (age= 20 ± 1 years). Immediately prior to the …

Strategies For Health Literacy Assessment And Patient Education In Athletic Training Practice: A Cross-Sectional Analysis, Stephanie R. Toubman, Justin Young, Lindsey E. Eberman, Matthew J. Rivera

Internet Journal of Allied Health Sciences and Practice

Purpose: Health literacy plays a vital role in patients’ health and dictates their ability to locate, process, and understand basic health information to make informed decisions. Athletic trainers in the secondary school (SSATs) setting work with patients with varying health literacy levels. The purpose of this study was to explore SSATs' knowledge of health literacy and integration of best practice behaviors for patient education. Methods: A cross-sectional design, web-based survey including demographic, patient education practice behaviors, and health literacy knowledge assessment questions. Practice behavior questions identified techniques, strategies, and educational materials used during patient education. Health literacy knowledge assessment …

Re-Envisioning Throwing Programs For Baseball Pitchers: A Case Report And Literature Review, S. Andrew Cage, Alexander P. Jacobsen, Clayton Hodges, Cassandra Rasmussen, Jon-Michael Cline, Brandon J. Warner, Lynzi K. Warner, Laurel Trail, Ryan Johnson, Matt Schimpf, Pauline Skowron, Robert French, Derek Lege, Nathan Campbell

Internet Journal of Allied Health Sciences and Practice

This case report follows the injury presentation and return to pitching of two NCAA Division II baseball pitchers. A literature review is provided to detail the current prevalence and epidemiology related to injuries to the throwing arm of pitchers. The review also outlines current procedures for returning a baseball pitcher to pitching from the mound. The authors discuss key concepts related to progressing previously injured pitchers back to pitching from the mound, while using the two cases presented as exemplars for using the objective, goal oriented, and adaptable interval throwing program developed at the pitchers’ university.

Congenital Rickets, Melissa Intriago

Mako: NSU Undergraduate Student Journal

No abstract provided.

One Heart, One Vessel: Unraveling The Mystery Of Truncus Arteriosus, Claudette C. Artiles

Mako: NSU Undergraduate Student Journal

No abstract provided.

What’S New In Esophageal Atresia Treatment?, Alexandra N. Jimenez Gonzalez

Mako: NSU Undergraduate Student Journal

No abstract provided.

Comprehensive Overview Of Gastroschisis, Alexis Carver

Mako: NSU Undergraduate Student Journal

Gastroschisis is a congenital defect of the abdominal wall viscera that occurs during early embryonic development, leading to the protrusion of bowel through an opening near the umbilical cord. This condition is classified as either simple, involving only the bowel, or complex, involving additional complications like necrosis or intestinal atresia. While the exact cause of gastroschisis remains unknown, it is believed to be influenced by a combination of genetic and environmental factors. This congenital disorder affects a very small percentage of neonates, and the associated mortality rates are relatively low due to modern developments in medical science. Gastroschisis can be …

How Did Covid-19 Impact Physiology Research Globally? – Lessons Learned And Future Recommendations, Jeet Patel, Santanu De

Mako: NSU Undergraduate Student Journal

The Coronavirus Infectious Disease 2019 (COVID-19) pandemic caused massive changes in the medical field across the globe. As the whole world moved from in-person to remote activities, students found themselves in a predicament where they were compelled towards schooling and work online from home. This would mean that all projects, research, tests, and meetings were conducted over Zoom or other online meeting platforms. Laboratories were shut down or only a limited number of people were allowed to enter to conduct the necessary research. This paper discusses how the COVID-19 pandemic affected research process and experiments within various aspects of the …

Parallels Between Internet And Stimulant Drug Addiction, Yashica Bhuvane

Mako: NSU Undergraduate Student Journal

This analysis explores how stimulant addictions—specifically cocaine, methamphetamines, and nicotine—impact the brain's reward system, comparing these effects with those seen in Internet Addiction (IA). Drawing from functional magnetic resonance imaging (fMRI) studies, it assesses changes in key brain regions involved in reward processing, craving, and cognitive control related to these addictive behaviors. The analysis investigates how each stimulant affects dopaminergic transmission and disrupts reward circuitry, highlighting both similarities and differences in brain activation patterns linked to addiction. By comparing these patterns with those seen in IA, the analysis aims to identify which stimulant most closely resembles the neural disruptions associated …

Assessment Of Omentin-1 In Diabetic Nephropathy And Insulin Resistance Individuals In Type 2 Diabetic Patients, Nabaa Najam. Abd Zaid Alshamiry, Nibras Hussain. Abdulsada Al-Ghuraibawi

Maaen Journal for Medical Sciences

A case-control study at AL-Sadar Teaching Hospital/Al-Najaf Center found a negative correlation between serum omentin-1 levels and diabetic nephropathy, suggesting early detection of microvascular complications. Long-term diabetes increases the risk of complications, including nephropathy, which worsens over time. High blood pressure is a common comorbidity among diabetics, and careful glycemic control is necessary in advanced stages. Omentin-1 plays a role in enhancing insulin sensitivity and glucose metabolism, but further investigation is needed to determine diabetic nephropathy severity in T2DM patients.

Evaluation Of A Guide To Accessing Accommodations During Medical School Created By And For Students With Disabilities, Nora Newcomb, Emily Coughlin, Zainub Dhanani, Kie Fujii, Lily Upp, Harika Kottakota, Rahul Mhaskar, Andrew Galligan

Journal of Science Education for Students with Disabilities

Medical students with disabilities constitute 7.6% of allopathic (MD) and 4.3% of osteopathic (DO) programs, and they are entitled to reasonable accommodation, per the Americans with Disabilities Act. However, research has demonstrated that disabled medical students often encounter barriers when accessing accommodations. In response to these barriers, Medical Students with Chronic Illness and Disability (MSDCI) National created the MSDCI Guide to Accessing Disability Accommodations During Undergraduate Medical Education (the Guide). We conducted a program evaluation to evaluate the efficacy of the Guide as a resource to the members of MSDCI, a program evaluation was conducted. A Qualtrics survey was distributed …

Does Body Mass Index Influence Intraoperative Costs And Operative Times For Open Transforaminal Lumbar Interbody Fusion? A Time-Driven Activity-Based Costing Analysis, Danyal A. Quraishi, Advith Sarikonda, Dwight M. Self, Emily Isch, Steven R. Glener, Arbaz A. Momin, Ashmal Sami, Nicholas Clark, Joshua Pelta-Heller, Srinivas Prasad, Ashwini Sharan, Jack Jallo, James Harrop, Alex R. Vaccaro, Ahilan Sivaganesan

Department of Neuroscience Faculty Papers

BACKGROUND: The increasing prevalence of obesity has raised concerns about its impact on surgical outcomes and healthcare costs. This study evaluates the influence of Body Mass Index (BMI) on intraoperative costs and operative times during open Transforaminal Lumbar Interbody Fusion (TLIF) procedures using a Time-Driven Activity-Based Costing (TDABC) approach.

METHODS: A retrospective analysis was conducted on 279 patients who underwent TLIF between 2019 and 2022. Patients were categorized into 5 BMI cohorts: healthy weight (BMI 18.5-24.99), overweight (BMI 25.0-29.99), Class I obese (BMI 30.0-34.99), Class II obese (BMI 35.0-39.99), and Class III obese (BMI >40). Intraoperative costs were calculated using …

Analyzing And Mitigating The Risks Of Patient Harm During Operating Room To Intensive Care Unit Patient Handoffs., Nara Regina Spall Martins, Edson Zangiacomi Martinez, Cláudia Marquez Simões, Paul Barach, Maria José Carvalho Carmona

SKMC Student Presentations and Publications

Patients continue to suffer from preventable harm and uneven quality outcomes. Reliable clinical outcomes depend on the quality of robust administrative systems and reliable support processes. Critically ill patient handoffs from the operating room (OR) to the intensive care unit (ICU) are known to be high-risk events. We describe a novel perspective on how risk factors associated with the process of patient handoff communication between the OR and the ICU can lead to flawed communication, degraded team awareness, medical errors, and increased patient harm. Data were collected from two semi-structured focus groups using a five-step risk management approach at a …

Economic Impact And Clinical Benefits Of Clinical Pharmacy Interventions: A Six-Year Multi-Center Study Using An Innovative Medication Management Tool, Watheq M. Alsetohy, Kareem A. El-Fass, Seif El Hadidi, Mohammad F. Zaitoun, Osama Badary, Kareem Ali, Ahmed Ezz-Elden, Mohamed R. Ibrahim, Bahaa S. Makhlouf, Asmaa Hamdy, Noha S. El Baghdady, Maha Gamal Eldien, Sherif Allama, Amr A. Alashkar, Ahmed Seyam, Nanees Adel, Ahmed R. N. Ibrahim, Hany V. Zaki

Pharmacy

Background

Increasing healthcare costs, particularly in Low- and Middle-Income Countries (LMICs) like Egypt, highlight the need for rational economic strategies. Clinical pharmacy interventions offer potential benefits by reducing drug therapy problems and associated costs, thereby supporting healthcare system sustainability.

Objective

This study evaluates the economic impact and clinical benefits of clinical pharmacy interventions in four tertiary hospitals in Egypt by implementing an innovative tool for medication management, focusing on cost avoidance and return on investment (ROI), while accounting for case severity and drug therapy problem (DTP) resolution.

Methods

Utilizing a digital tool, cost avoidance was assessed by considering the severity …

Artificial Intelligence For The Detection Of Acute Myeloid Leukemia From Microscopic Blood Images; A Systematic Review And Meta-Analysis, Feras Al-Obeidat, Wael Hafez, Asrar Rashid, Mahir Khalil Jallo, Munier Gador, Ivan Cherrez-Ojeda, Daniel (Centro De Investigación De Salud Pública Y Epidemiología Clínica Simancas-Racines, , Universidad Ute, Quito, Ecuador , Universidad Ute, Quito, Ecuador

All Works

Leukemia is the 11th most prevalent type of cancer worldwide, with acute myeloid leukemia (AML) being the most frequent malignant blood malignancy in adults. Microscopic blood tests are the most common methods for identifying leukemia subtypes. An automated optical image-processing system using artificial intelligence (AI) has recently been applied to facilitate clinical decision-making. To evaluate the performance of all AI-based approaches for the detection and diagnosis of acute myeloid leukemia (AML). Medical databases including PubMed, Web of Science, and Scopus were searched until December 2023. We used the “metafor” and “metagen” libraries in R to analyze the different models used …

Alpha Synuclein And Inflammaging, Geneviève L. Putnam, Robert W. Maitta

Faculty Scholarship

The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with inflammasomes in response to aging. As age is an inevitable physiological state and is also considered the greatest risk factor for PD, this calls for investigation into how α-syn, aging, and PD could be linked. There is a growing amount of data regarding α-syn normal function in the body that includes involvement in cellular transport such as protein complexes assembly, vesicular trafficking, neurotransmitter release, …

Lumen-Apposing Metal Stent Placement In Severe Sepsis Secondary To Afferent Limb Syndrome, Nicholas Noverati, Faisal Kamal

Division of Gastroenterology and Hepatology Faculty Papers

No abstract provided.

Development Of Spray-Dried Micelles, Liposomes, And Solid Lipid Nanoparticles For Enhanced Stability, Shradha Dattani, Xiaoling Li, Charina Lampa, Amanda Barriscale, Behzad Damadzadeh, David Lechuga-Ballesteros, Bhaskara R. Jasti

Pacific Faculty Work

Objectives: Micelles, liposomes, and solid lipid nanoparticles (SLNs) are promising drug delivery vehicles; however, poor aqueous stability requires post-processing drying methods for maintaining long-term stability. The objective of this study was to compare the potential of lipid-based micelles, liposomes, and SLNs for producing stable re-dispersible spray-dried powders with trehalose or a combination of trehalose and L-leucine. This study provides novel insights into the implementation of spray drying as a technique to enhance long-term stability for these lipid-based nanocarriers. Methods: Aqueous dispersions of LDV-targeted micelles, liposomes, and SLNs loaded with paclitaxel (PTX) were converted into re-dispersible powders using spray drying. The …

Il-1Β In Neoplastic Disease And The Role Of Its Tumor-Derived Form In The Progression And Treatment Of Metastatic Prostate Cancer, Yetunde Oyende, Luke Taus, Alessandro Fatatis

Kimmel Cancer Center Faculty Papers

Since its discovery, IL-1β has taken center stage as a key mediator of a very broad spectrum of diseases revolving around immuno-mediated and inflammatory events. Predictably, the pleiotropic nature of this cytokine in human pathology has led to the development of targeted therapeutics with multiple treatment indications in the clinic. Following the accumulated findings of IL-1β's central modulatory role in the immune system and the implication of inflammatory pathways in cancer, the use of IL-1β antagonists was first proposed and then also pursued for oncology disorders. However, this approach has consistently relied on the perceived need of interfering with IL-1β …

Viroporin Activity Is Necessary For Intercellular Calcium Signals That Contribute To Viral Pathogenesis, J Thomas Gebert, Francesca J Scribano, Kristen A Engevik, Ethan M Huleatt, Michael R Eledge, Lauren E Dorn, Asha A Philip, Takahiro Kawagishi, Harry B Greenberg, John T Patton, Joseph M Hyser

Faculty, Staff and Students Publications

Viruses engage in a variety of processes to subvert host defenses and create an environment amenable to replication. Here, using rotavirus as a prototype, we show that calcium conductance out of the endoplasmic reticulum by the virus encoded ion channel, NSP4, induces intercellular calcium waves that extend beyond the infected cell and contribute to pathogenesis. Viruses that lack the ability to induce this signaling show diminished viral shedding and attenuated disease in a mouse model of rotavirus diarrhea. This implicates nonstructural protein 4 (NSP4) as a virulence factor and provides mechanistic insight into its mode of action. Critically, this …

Nkapl Facilitates Transcription Pause-Release And Bridges Elongation To Initiation During Meiosis Exit, Zhenlong Kang, Chen Xu, Shuai Lu, Jie Gong, Ruoyu Yan, Gan Luo, Yuanyuan Wang, Qing He, Yifei Wu, Yitong Yan, Baomei Qian, Shenglin Han, Zhiwen Bu, Jinwen Zhang, Xian Xia, Liang Chen, Zhibin Hu, Mingyan Lin, Zheng Sun, Yayun Gu, Lan Ye

Faculty, Staff and Students Publications

Transcription elongation, especially RNA polymerase II (Pol II) pause-release, is less studied than transcription initiation in regulating gene expression during meiosis. It is also unclear how transcription elongation interplays with transcription initiation. Here, we show that depletion of NKAPL, a testis-specific protein distantly related to RNA splicing factors, causes male infertility in mice by blocking the meiotic exit and downregulating haploid genes. NKAPL binds to promoter-associated nascent transcripts and co-localizes with DNA-RNA hybrid R-loop structures at GAA-rich loci to enhance R-loop formation and facilitate Pol II pause-release. NKAPL depletion prolongs Pol II pauses and stalls the SOX30/HDAC3 transcription initiation complex …

Prevalence Of High Tricuspid Regurgitation Jet Velocity In Patients With Sickle Cell Disease, Asaad Faisal Alkuheli, Meaad Kadhum Hassan, Jawad Atiya

Iraqi National Journal of Medicine

Background: Elevated tricuspid regurgitation jet velocity (TRV) is a key indicator of pulmonary hypertension (PHT) in sickle cell disease (SCD) patients, with SCD occurring frequently in both adults and children. Aim: This study aimed to estimate TRV through echocardiography and assess the presence of comorbidities in SCD patients at the Center of Hereditary Blood Diseases. It further aimed to determine the percentage of elevated TRV and its relationship to various SCD-related variables. Methods: A cross-sectional, descriptive study was conducted to assess TRV in children and adolescents with SCD registered at the Center of Hereditary Blood Diseases from October 1, 2021 …

Utilizing Patient-Derived Xenografts To Model Precision Oncology For Biliary Tract Cancer, Timothy P Diperi, Kurt W Evans, Stephen Scott, Xiaofeng Zheng, Kaushik Varadarajan, Lawrence N Kwong, Michael Kahle, Hop S Tran Cao, Ching-Wei Tzeng, Thuy Vu, Sunhee Kim, Fei Su, Maria Gabriela Raso, Yasmeen Rizvi, Ming Zhao, Huamin Wang, Sunyoung S Lee, Timothy A Yap, Jordi Rodon, Milind Javle, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Purpose: Biliary tract cancers, which are rare and aggressive malignancies, are rich in clinically actionable molecular alterations. A major challenge in the field is the paucity of clinically relevant biliary tract cancer models that recapitulate the diverse molecular profiles of these tumors. The purpose of this study was to curate a collection of patient-derived xenograft (PDX) models that reflect the spectrum of genomic alterations present in biliary tract cancers to create a resource for modeling precision oncology.

Experimental design: PDXs were derived from biliary tract cancer samples collected from surgical resections or metastatic biopsies. Alterations present in the PDXs were …

Revisiting Phosphoregulation Of Cdc25c During M-Phase Induction, Tan Tan, Chuanfen Wu, Ruoning Wang, Bih-Fang Pan, David Hawke, Fumin Yin, Zehao Su, Boye Liu, Sue-Hwa Lin, Wei Zhang, Jian Kuang

Faculty, Staff and Student Publications

Cdc25C undergoes a sudden and substantial gel mobility shift at M-phase onset, correlating with abrupt activation of both Cdc25C and Cdk1 activities. A positive feedback loop between Cdk1 and Cdc25C has been used to explain this hallmark phenomenon. Here, we demonstrate that the M-phase supershift and robust activation of Cdc25C are due to the site-comprehensive phosphorylation of its long intrinsically disordered regulatory domain without requiring Cdk1 or other major mitotic kinase activities. The phosphorylation process involves substrate-mediated assembly of phosphorylation machinery that catalyzes multisite phosphorylation continuously without substrate dissociation. In contrast to the site-comprehensive phosphorylation of Cdc25C occurring at M-phase …

Innervation Of Human Intestinal Organoids, Rachel C Bordelon, Madushani Herath, Allison L Speer

Faculty, Staff and Student Publications

The complexity of intestinal cytoarchitecture and function poses significant challenges for the creation of the bioengineered small intestine. Techniques for generating human intestinal organoids (HIOs) resembling human small intestine have been previously reported. HIOs contain epithelium and mesenchyme but lack other critical components of functional intestine such as the enteric nervous system (ENS), immune cells, vasculature, and microbiome. Two independent research groups have published distinct methods to innervate HIOs with an ENS. Here we discuss a unique method of incorporating the ENS into an HIO-derived bioengineered small intestine, which utilizes components of these prior reports to optimize progenitor cell identity …

Supplementary Motor Area In Speech Initiation: A Large-Scale Intracranial Eeg Evaluation Of Stereotyped Word Articulation, Latané Bullock, Kiefer J Forseth, Oscar Woolnough, Patrick S Rollo, Nitin Tandon

Faculty, Staff and Student Publications

Speech production engages a distributed network of cortical and subcortical brain regions. The supplementary motor area (SMA) has long been thought to be a key hub in coordinating across these regions to initiate voluntary movements, including speech. We analyzed direct intracranial recordings from 115 patients with epilepsy as they articulated a single word in a subset of trials from a picture-naming task. We aimed to characterize the temporal dynamics of SMA relative to other cortical regions. SMA and preSMA were among the first regions to activate after cue onset, peaked in activity before articulation onset, and were the earliest regions …

Update On Pediatric Surveillance Recommendations For Pten Hamartoma Tumor Syndrome, Dicer1-Related Tumor Predisposition, And Tuberous Sclerosis Complex, Kris Ann P Schultz, Suzanne P Macfarland, Melissa R Perrino, Sarah G Mitchell, Junne Kamihara, Alexander T Nelson, Paige H R Mallinger, Jack J Brzezinski, Kara N Maxwell, Emma R Woodward, Bailey Gallinger, Sun Young Kim, Mary-Louise C Greer, Kami Wolfe Schneider, Sarah R Scollon, Anirban Das, Jonathan D Wasserman, Charis Eng, David Malkin, William D Foulkes, Orli Michaeli, Andrew J Bauer, Douglas R Stewart

Faculty, Staff and Students Publications

Phosphate and tensin homolog hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex are rare conditions, which each increases risk for distinct spectra of benign and malignant neoplasms throughout childhood and adulthood. Surveillance considerations for each of these conditions focus on patient and family education, early detection, and multidisciplinary care. In this article, we present updated surveillance recommendations and considerations for children and adolescents with phosphate and tensin homolog hamartoma tumor syndrome, DICER1-related tumor predisposition, and tuberous sclerosis complex and provide suggestions for further research in each of these conditions.