Medicine and Health Sciences Commons^™

Investigating Comorbidities And Heritability Of Chronic Intractable Migraine With Reactive Hypoglycemia, Stella Santa Ana, Alexander Baumann, Benjamin Gordon, Alex Schofield, Sophia Delgado, Catherine Yvonne Russell, Jacob Warner, Christina Nelson, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

Poster at 2025 Roseman Research Symposium

Dental Phobia And Oral Health: Assessing Its Impact On Quality Of Life, Mahak Sargodhia, Kamran H. Awan

Annual Research Symposium

No abstract provided.

Characteristics Of Athletic Trainers That Are Satisfied And Dissatisfied With Their Compensation, K Ef Mair, J P. Young, L E. Eberman

Clinical Practice in Athletic Training

Introduction: Job satisfaction among athletic trainers (ATs), particularly in relation to compensation, is a critical factor influencing retention and career fulfillment. Examining the factors linked to earnings satisfaction may offer insight into how workplace conditions can be improved to better support ATs. The purpose of our study was to investigate the attributes that distinguish ATs content with their compensation from those who are dissatisfied. Methods: We used a cross-sectional, web-based survey to gather AT compensation data, of which 1,887 participants responded to a question regarding their satisfaction with compensation. Respondents were divided into two groups based on their satisfaction with …

Development Of A Conditional Plasmid For Gene Deletion In Non-Model Fusobacterium Nucleatum Strains, Peng Zhou, Bibek G C, Chenggang Wu

Faculty, Staff and Student Publications

Fusobacterium nucleatum is an opportunistic pathogen with four subspecies: nucleatum (FNN), vincentii (FNV), polymorphum (FNP), and animalis (FNA), each with distinct disease potentials. Research on fusobacterial pathogenesis has mainly focused on the model strain ATCC 23726 from FNN. However, this narrow focus may overlook significant behaviors of other FNN strains and those from other subspecies, given the genetic and phenotypic diversity within F. nucleatum. While ATCC 23726 is highly transformable, most other Fusobacterium strains exhibit low transformation efficiency, complicating traditional gene deletion methods that rely on non-replicating plasmids. To address this, we developed a conditional plasmid system in which …

Benefits Of Equilibrium Between Microbiota- And Host-Derived Ligands Of The Aryl Hydrocarbon Receptor After Stroke In Aged Male Mice, Pedram Peesh, Maria P Blasco-Conesa, Ahmad El Hamamy, Romeesa Khan, Gary U Guzman, Parisa Honarpisheh, Eric C Mohan, Grant W Goodman, Justin N Nguyen, Anik Banerjee, Bryce E West, Kyung Ae Ko, Janelle M Korf, Chunfeng Tan, Huihui Fan, Gabriela D Colpo, Hilda Ahnstedt, Lucy Couture, Solji Roh, Julia K Kofler, Jose F Moruno-Manchon, Michael E Maniskas, Jaroslaw Aronowski, Rodney M Ritzel, Juneyoung Lee, Jun Li, Robert M Bryan, Anjali Chauhan, Venugopal Reddy Venna, Louise D Mccullough, Bhanu Priya Ganesh

Faculty, Staff and Student Publications

Recent studies have highlighted the crucial role of microglia (MG) and their interactions with the gut microbiome in post-stroke neuroinflammation. The activation of immunoregulatory pathways, including the aryl hydrocarbon receptor (AHR) pathway, is influenced by a dynamic balance of ligands derived from both the host and microbiota. This study aimed to investigate the association between stroke-induced dysbiosis and the resultant imbalance in AHR ligand sources (loss of microbiota-derived [indole-based] and increase of host-derived [kynurenine-based]) after stroke. Microbiota-derived AHR ligands decreased in human plasma and remained low for days following an ischemic stroke highlighting the translational significance. Transient-middle-cerebral-artery-occlusion was performed in …

Cardiovascular Comorbidities In Chinese Inpatients With Schizophrenia Spectrum Disorders, Zhe Dong, Gang Wu, Hongbing Liu, Song Chen, Bin Bi, Fangfang Zhang, Yi Yin, Wei Qu, Baopeng Tian, Fude Yang, Alice Kochunov, Peter Kochunov, Shengmei Ban, Yang Zhao, L Elliot Hong, Yunlong Tan

Faculty, Staff and Student Publications

Cardiovascular diseases (CVDs) are the leading cause of premature mortality in patients with schizophrenia spectrum disorders (SSDs). However, the detailed categorization of these conditions remains insufficiently explored. This study aims to identify CVDs comorbidity patterns among inpatients with SSDs and to investigate associated factors. Electronic medical records (EMRs) data from three neuropsychiatric hospitals (2015-2023) in China was conducted. Comorbidity patterns were revealed through latent class analysis (LCA), and multinomial logit analysis were utilized to evaluate the effect of factors on these patterns, calculating odds ratios (ORs) and 95% confidence intervals (CIs). Among the 2830 inpatients with SSD, four distinct comorbidity …

Early Application Value Of Flexible Laryngoscope Swallowing Function Assessment In Patients After Partial Laryngectomy, Lina Jia, Chenxu Yan, Run Liu, Pengfei He, Ailing Liu, Fei Yang, Hui Huangfu, Sen Zhang

Faculty, Staff and Student Publications

To investigate the influence of early dysphagia on quality of life in patients with partial laryngectomy, and to investigate the application value of Flexible Endoscopic Evaluation of Swallowing (FEES). This study included 30 inpatients who underwent partial laryngectomy due to laryngeal cancer. In the early postoperative period, a comprehensive assessment was conducted on each patient, encompassing Videofluoroscopic Swallowing Study (VFSS), Flexible Endoscopic Evaluation of Swallowing (FEES), and MD Anderson Dysphagia Inventory (MDADI). Each patient underwent two evaluations at different time points following the surgical procedure, all conducted on the same day. The patients' first MDADI assement score after surgery was …

The Effects Of A Joint Reduction Trainer On Confidence Levels In Professional Athletic Training Students, T Franklin, S Hacherl

Clinical Practice in Athletic Training

Introduction: Dislocations are common injuries managed by athletic trainers, yet athletic training students are unlikely to practice reduction techniques during clinical experiences. Current standards set by the Commission on Accreditation of Athletic Training Education require accredited programs to prepare students to manage patients with dislocations, including joint reductions. Research indicates the use of simulation techniques, such as joint reduction simulators, in education can fill clinical experience gaps and improve student confidence and skills. Shoulder dislocations make up nearly 50% of dislocations with several reduction techniques identified in the current literature. The use of a joint reduction simulator may provide athletic …

Parent And Child Attachment-Like Behaviors With Conversational Ai Agents And Perceptions Of Impact On Family Dynamics, Brandon T. Mcdaniel Phd, Amanda Coupe, Allison Weston, Jessica Pater

Health Services and Informatics Research

Objective: We explored parents’ and children’s attachment-like behaviors with artificial intelligence (AI)-enabled smart speakers (often called digital assistants; DAs) and associations with perceived impacts on family dynamics. Background: DAs (e.g., Alexa) are increasingly integrated into homes, with prior research reporting varied uses, benefits, and concerns, including perceived emotional attachments among children. Method: We conducted an online survey of 351 parents who owned DAs to assess frequency of use, perception of positive/negative impacts, and attachment-like behaviors with DAs. Utilizing linear regression we examined associations between variables. Results: Approximately half reported at least daily DA use. Overall, participants reported moderate attachment-like behavior, …

Silencing Faf2 Mitigates Alcohol-Induced Hepatic Steatosis By Modulating Lipolysis And Pcsk9 Pathway, Nazmul Huda, Praveen Kusumanchi, Yanchao Jiang, Hui Gao, Themis Thoudam, Ge Zeng, Nicholas J. Skill, Zhaoli Sun, Suthat Liangpunsakul, Jing Ma, Zhihong Yang

School of Medicine Faculty Publications

BACKGROUND: Chronic alcohol consumption leads to lipid accumulation, oxidative stress, cellular damage, and inflammation in the liver, collectively referred to as alcohol-associated liver disease (ALD). FAF2/UBXD8/ETEA (Fas-associated factor 2) is a ubiquitin ligase adaptor protein that plays a crucial role in the ubiquitin-mediated degradation of misfolded proteins in the endoplasmic reticulum. A recent genome-wide association study indicated an association between FAF2 and ALD; however, the exact contribution of FAF2 to ALD pathogenesis remains unclear. METHODS: FAF2 was knocked down using AAV-delivered shRNA in C57/BL6 mice. Mice were subjected to a chronic-plus-single binge ethanol feeding (NIAAA) model. Nine hours after gavage, …

Successful Endovascular Management Of Concomitant Ischemic Stroke, Myocardial Infarction, And Massive Pulmonary Embolism, Ryan W Nolan, Naganathan B Mani, Amir Ata Rahnemai-Azar, Sriya Kosaraju, Arindam Chatterjee, Jasvindar Singh, Pavan Kumar Kavali

2020-Current year OA Pubs

BACKGROUND: Ischemic stroke, myocardial infarction (MI), and pulmonary embolism (PE) are emergent conditions which can be treated with catheter-directed therapies. Concomitant management of these conditions with catheter-directed therapy is not well-documented and lacks strong guidelines.

CASE SUMMARY: A 70-year-old woman presented with stroke symptoms and ST-segment elevation MI. Rapid stroke protocol imaging confirmed ischemic stroke and extensive bilateral PE. To address these conditions rapidly and because of contraindications for systemic thrombolysis, she underwent percutaneous coronary intervention without stenting, stroke thrombectomy, and finally pulmonary thrombectomy.

DISCUSSION: This case provides insight into the management of a patient with 3 emergent pathologies with …

Chromosomal And Gonadal Sex Have Differing Effects On Social Motivation In Mice, Sneha M Chaturvedi, Simona Sarafinovska, Din Selmanovic, Katherine B Mccullough, Raylynn G Swift, Susan E Maloney, Joseph D Dougherty

2020-Current year OA Pubs

BACKGROUND: Sex differences in brain development are thought to lead to sex variation in social behavior. Sex differences are fundamentally driven by both gonadal hormones and sex chromosomes, yet little is known about the independent effects of each on social behavior. Further, mouse models of the genetic liability for the neurodevelopmental disorder MYT1L Syndrome have shown sex-specific deficits in social motivation. In this study, we aimed to determine if gonadal hormones or sex chromosomes primarily mediate the sex differences seen in mouse social behavior, both at baseline and in the context of Myt1l haploinsufficiency.

METHODS: Four-core genotypes (FCG) mice, which …

Targeting Fatty Acid Synthase Reduces Aortic Atherosclerosis And Inflammation, Rodrigo Meade, Dina Ibrahim, Connor Engel, Larisa Belaygorod, Batool Arif, Fong-Fu Hsu, Sangeeta Adak, Ryan Catlett, Mingzhou Zhou, Ma Xenia G Ilagan, Clay F Semenkovich, Mohamed A Zayed

2020-Current year OA Pubs

Fatty acid synthase (FAS) is predominantly expressed in the liver and adipose tissue. It plays vital roles in de novo synthesis of saturated fatty acids and regulates insulin sensitivity. We previously demonstrated that serum circulating FAS (cFAS) is a clinical biomarker for advanced atherosclerosis, and that it is conjugated to low-density lipoproteins (LDL). However, it remains unknown whether cFAS can directly impact atheroprogression. To investigate this, we evaluate whether cFAS impacts macrophage foam cell formation - an important cellular process leading to atheroprogression. Macrophages exposed to human serum containing high levels of cFAS show increased foam cell formation as compared …

Assessing The Contribution Of Rare Protein-Coding Germline Variants To Prostate Cancer Risk And Severity In 37,184 Cases, Jonathan Mitchell, Niedzica Camacho, Patrick Shea, Konrad H Stopsack, Vijai Joseph, Oliver S Burren, Ryan S Dhindsa, Abhishek Nag, Jacob E Berchuck, Amanda O'Neill, Ali Abbasi, Anthony W Zoghbi, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen, Roberto Tapia-Conyer, Jonathan Emberson, Jason M Torres, Rory Collins, Quanli Wang, David Goldstein, Athena Matakidou, Carolina Haefliger, Lauren Anderson-Dring, Ruth March, Vaidehi Jobanputra, Brian Dougherty, Keren Carss, Slavé Petrovski, Philip W Kantoff, Kenneth Offit, Lorelei A Mucci, Mark Pomerantz, Margarete A Fabre

Faculty, Staff and Students Publications

To assess the contribution of rare coding germline genetic variants to prostate cancer risk and severity, we perform here a meta-analysis of 37,184 prostate cancer cases and 331,329 male controls from five cohorts with germline whole exome or genome sequencing data, and one cohort with imputed array data. At the gene level, our case-control collapsing analysis confirms associations between rare damaging variants in four genes and increased prostate cancer risk: SAMHD1, BRCA2 and ATM at the study-wide significance level (P <  1×10−8), and CHEK2 at the suggestive threshold (P <  2.6×10−6). Our case-only analysis, reveals that rare damaging variants in AOX1 are associated with more aggressive disease (OR = 2.60 [1.75–3.83], …

Trem2 Promotes Lung Fibrosis Via Controlling Alveolar Macrophage Survival And Pro-Fibrotic Activity, Huachun Cui, Sami Banerjee, Na Xie, Musaddique Hussain, Ashish Jaiswal, Hongli Liu, Tejaswini Kulkarni, Veena B Antony, Rui-Ming Liu, Marco Colonna, Gang Liu

2020-Current year OA Pubs

Lung macrophages play a pivotal role in pulmonary fibrosis, with monocyte-derived alveolar macrophages driving disease progression. However, the mechanisms regulating their pro-fibrotic behavior and survival remain unclear, and effective therapeutic strategies are lacking. Here we show that triggering receptors expressed on myeloid cells 2 are predominantly expressed on monocyte-derived alveolar macrophages in fibrotic mouse lungs and are significantly elevated in lung macrophages from patients with idiopathic pulmonary fibrosis. Deletion or knockdown of this receptor disrupts intracellular survival signaling, promotes macrophage apoptosis, and attenuates their pro-fibrotic phenotype. We further demonstrate that a lipid mediator and a high-avidity ligand of this receptor, …

Collaborative Healthcare: Advancing Interprofessional Practice & Education, Volume 15, Number 1, Fall 2024/Winter 2025

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

In this Issue:

• From the Editors
• JCIPE Certificate of Excellence in Interprofessional Collaborative Practice
• Welcoming New Faces
• Meet an IPE/CP Faculty Champion
• Meet an IPE/CP Student Champion
• Transformative Learning Through IPE
• Interprofessional Palliative Care Program

United In Inquiry: Exploring Interprofessional Collaboration In Healthcare Research, Srinija Balabhadra, Harshita Sarambale, Sherli Koshy-Chenthittayil Phd, John Rider Phd

Annual Research Symposium

This poster explores an interprofessional research project conducted by an OT professional, a data analyst and two medical students at Touro University Nevada.

A Narrative Review Of Barriers To Utilization Of Surgical Risk Assessment Calculators, Jacob Lahti, Kaiya A. Noe, Abigail Veenstra, Sarah Gallitto, Victoria I. De Leon, Thomas C. Varkey, Nimit Agarwal

Annual Research Symposium

Over the last several decades, it has become the desire of surgical and medical teams to decrease risk levels involved for patients undergoing surgery. However, despite the advent of risk assessment calculators to help physicians obtain more accurate and objective judgements for postoperative complications, these tools are underutilized in standard clinical practices in comparison to other methods of risk assessment. This is likely due at least in part to certain barriers that decrease their functionality and ease of use. This review discusses the major barriers to the utilization of current risk calculators so as to allow for a better understanding …

The Effects Of Smokeless Tobacco Products And Affiliates On Epigenetic Changes And Biomarkers, Saad Saeed, Kamran Awan

Annual Research Symposium

No abstract provided.

Investigating The Relationship Between The Circadian Clock, Age, And Lifestyle, Samuel Park, Amaka Eziakonwa, Amega Nguyen, Madison Payne, Erich Stahmer, Alexis Salinas, Payson Broome, Angel Oliver, Christian Mccormick, Jasmyn Brown, Julie A. Zacharias-Simpson, Jutta Ward, Deborah Bell-Pedersen

Annual Research Symposium

This poster presentation aims to understand how circadian clock strength and phase are affected by age and lifestyle. By analyzing changes in physiological rhythms, the study seeks to develop strategies for promoting healthy aging by optimizing circadian function.

The Effectiveness Of Cochlear Implants On Cognitive Function In Children And Adolescents With Hearing Loss: A Systematic Review, Harshita Sarambale, Joshua Ahdout, Srinija Balabhadra, Yesenia Valle Ramirez, John V. Rider Phd, Otr/L, M. De Armond Mfa, Mslis, S. Koshy-Chenthittayil Phd

Annual Research Symposium

This ongoing research project is a medical student led systematic review on cognitive function in pediatric cochlear implant patients.

Silver Diamine Fluoride And Oral Health Equity: Clinical And Public Health Perspectives, Rheannon Ainsworth, William Carroll Dds

Annual Research Symposium

11th Annual Roseman University Research Symposium.

Using Detrended Fluctuation Analysis To Determine The Effects Of Footwear On Postural Dynamics In Children, Samantha Martinez, Crystal S. Trevino, Bryon C. Applequist

International Journal of Exercise Science: Conference Proceedings

ABSTRACT

Footwear, particularly stiff-soled shoes, can impact postural control in young children during a critical period of motor development. While proprioception plays a key role in maintaining balance, shoes may restrict natural movement, potentially affecting overall posture and proprioceptive abilities. This study examines how stiff-soled footwear influences postural control during quiet standing in children. PURPOSE: This study aimed to explore the influence of stiff-soled footwear on postural control in young children by analyzing balance and stability during quiet standing. Specifically, we assessed whether wearing footwear with various degrees of stiffness influenced the temporal correlations of center of pressure (COP). …

Treadmill Training Program For A Non-Ambulatory Individual With Spastic Quadriplegic Cerebral Palsy, Krysta V. Rivero Romero, Vanessa Mikan Phd, Edward Merritt

International Journal of Exercise Science: Conference Proceedings

CASE HISTORY: 26-year-old Caucasian male. Primary medical history includes spastic quadriplegic cerebral palsy, otherwise negative health history. Presented to human performance laboratory for case study of pre- and post-exercise training cardiorespiratory fitness testing. PHYSICAL EXAM: Patient examination indicated bilateral upper and lower limb contractures, and bilateral upper and lower limb spasticity. Hyperlordosis was also noted. Patient had a limited range of motion across hip, knee, and ankle, and was unable to walk without support on a motorized treadmill. DIFFERENTIAL DIAGNOSES: General: Alert and oriented. Neural: spastic upper and lower extremities. Musculoskeletal: upper and lower extremity contractures. TESTS & RESULTS …

Mitochondrial Function In T-Cells: The Impact Of Cardiorespiratory Fitness And Body Fat In Men And Women, Nathan Fuentes, Emily Lavoy, Charlie Hodgman, Rebeka Hunt, Justin Crane, Micheal Herskowitz

International Journal of Exercise Science: Conference Proceedings

PURPOSE: Determine whether T-cell mitochondria differ in women and men categorized by cardiorespiratory fitness and percent body fat. METHODS: 9 women (age: (mean ± standard deviation) 29.2 ± 6.8 years) and 17 men (age: 28.0 ± 6.3 years) visited our laboratory for a body fat scan, donate blood sample and complete a VO2max test. For the VO2max test, participants were fitted with a heart rate monitor and a mask for breath analysis with a metabolic cart. Participants cycled on bicycle ergometer with the resistance increased 20 watts/minute until volitional exhaustion. Peripheral blood mononuclear cells were isolated and stained …

The Effect Of Footwear And Speed On Nonlinear Variability Of Runners, Kaleb Luna, Becca Henicke, Bryon C. Applequist

International Journal of Exercise Science: Conference Proceedings

The high incidence of foot and lower leg injury in adult walkers and runners and its relationship with footwear is a problem that has been investigated exhaustively (Barnes & Smith, 1994; Herzog, 2012; Knapik et al., 2014; Tancred, 1996).Traditionally, measures such as stride length, step length, step width, stride time and step time, as well as kinematic (joint angles) and kinetic (forces) measures have been used to quantify gait (Chang et al., 2006, Diop et al., 2005, Diop et al., 2004, Samson et al., 2009). These measures are important, but may not reveal the mechanism, or mechanisms affecting gait. Many …

Balance Control During Stair Descent In Older Adults, David Wyatt

International Journal of Exercise Science: Conference Proceedings

Falls during step descent are a significant risk for older adults, often hindering independence in daily activities such as stair descent and stepping off curbs. This study examines the effects of gait width and foot angle on stability and control during step descent. PURPOSE: To determine whether a wider gait with a 30-degree foot angle improves stability and reduces the risk of falls, thereby supporting safer and more independent mobility in older adults. METHODS: Participants aged 18-25 and 70-79, with no known gait impairments or balance disorders, performed a 14 cm step descent using a normal gait and a wider …

The Effect Of A Short-Term Antibiotic Cycle On Blood Biomarkers In Adults With Overweight And Obesity, Anne George, Melissa Fernandez Alonso, Ashlyn Dooley, Matthew Loritz, Jessica Mrosla, Olivia Landis, Katelyn Harnen, Genevieve Aiwonegbe, Meggan Duncan, Angela Berry, Jaidyn Hooper, Sarah Mckinley-Barnard, Elisa Marroquine, Ryan R. Porter

International Journal of Exercise Science: Conference Proceedings

It has been demonstrated in previous literature that early-life antibiotic exposure may contribute to metabolic dysfunction related to the development of overweight and obesity later in life. More recent studies suggest an additional relationship between antibiotic exposure beyond early life and obesity, as well as insulin resistance. However, there are a limited number of studies reporting the effects of short-term antibiotic exposure on insulin resistance and other blood biomarkers. PURPOSE: This study investigates the effects of short-term antibiotic exposure on insulin resistance and other blood biomarkers. METHODS: This study is part of a larger ongoing investigation examining the …

The Comparison Of Time To Peak Rapid Force Production In Division One Collegiate Male Football, Track, And Basketball Players, Anthony M. Rogers Jr, Matthew P. Gonzalez, Samuel Montalvo, Sandor Dorgo

International Journal of Exercise Science: Conference Proceedings

Sports such as football (FB), track (TR), and basketball (BB) use movements that require rapid force development in order to be successful. An athlete’s ability to generate power is vital for performance in these sports. While many studies have looked at rapid force development in one sport, there is a paucity of research when comparing athletes across different sports for their time to peak force development. PURPOSE: The purpose of this study was to compare male FB, BB, and TR athletes’ time to peak force and rate of development performance. METHODS: A total of 138 athletes (n=14 BB, n=108 FB, …

Paraspinal And Gastrocnemii Response To Shod And Barefoot Running With Rearfoot And Forefoot Landing, Shivaniba Gohil

International Journal of Exercise Science: Conference Proceedings

Barefoot (BF) and shod (S) running with conditions at heel landing (HS) and forefoot landing (FF) has impact on shock attenuation at the foot through the trunk. Muscle activation is crucial to understand the response of the system to vertical loading of the system during running. Purpose: This study investigated muscle activation in the gastrocnemii and lumbar paraspinal (LP) muscles during barefoot (BF) and shod (S) running with heel strike (HS) and forefoot strike (FF) landings to understand neuromuscular responses to vertical loading. Methods: Sixteen female collegiate runners (20.4 ± 3.2 yrs, 59.4 ± 7.7 kg, 1.63 ± 0.07 m) …