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Articles 31951 - 31980 of 325315

Full-Text Articles in Medicine and Health Sciences

Reimagining Stuttering Therapy And Outcomes Through An Acceptance And Collaborative Lens, Farzan Irani, Michael Azios, Michael Boyle, Geoffrey A. Coalson, Scott Palasik, Jack Rodriguez, Eric Swartz Mar 2025

Reimagining Stuttering Therapy And Outcomes Through An Acceptance And Collaborative Lens, Farzan Irani, Michael Azios, Michael Boyle, Geoffrey A. Coalson, Scott Palasik, Jack Rodriguez, Eric Swartz

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

The purpose of this paper is to summarize a panel discussion at the 2024 World Stuttering and Cluttering Organization Congress that aimed to explore and reflect on the shifting landscape of stuttering therapy across the lifespan. The panel comprised of speech-language pathologists who have experience in stuttering therapy as clients, professionals, and researchers. The panel members reflect on the research, their professional experiences, and their own personal journey toward a more acceptance-based therapy and its outcomes. The paper concludes with the panel's reflections on the future of stuttering therapy across the lifespan.


Predictors Of Mortality In Adults With Calcium Channel Blocker Toxicity Receiving Extracorporeal Membrane Oxygenation Support: An Extracorporeal Life Support Organization Registry Analysis, Rakeshkumar Subramanian, Amelia Roebuck, Hariom Joshi, Michelle Drouin Mar 2025

Predictors Of Mortality In Adults With Calcium Channel Blocker Toxicity Receiving Extracorporeal Membrane Oxygenation Support: An Extracorporeal Life Support Organization Registry Analysis, Rakeshkumar Subramanian, Amelia Roebuck, Hariom Joshi, Michelle Drouin

Hospital Medicine

Calcium channel blocker (CCB) toxicity presents a significant mortality risk, highlighting the need for effective treatment strategies such as extracorporeal membrane oxygenation (ECMO). This study analyzes Extracorporeal Life Support Organization (ELSO) registry data to determine the mortality rate in adults treated with ECMO for CCB toxicity and identifies clinical predictors of mortality. A retrospective analysis of the ELSO registry from January 2016 to April 2023 was conducted, focusing on adults diagnosed with CCB toxicity (ICD-10 T46.1) who received ECMO. Data collected included patient demographics, ECMO details (mode, duration, type), pre-ECMO clinical indicators (pH, lactate levels, cardiac arrest incidence), and in-hospital …


Applications Of Archaeal Antioxidant Coenzyme M As An Agricultural Biostimulant, Jeremy Hunter Brown Mar 2025

Applications Of Archaeal Antioxidant Coenzyme M As An Agricultural Biostimulant, Jeremy Hunter Brown

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

As the demand to meet global food security goals continue to increase, the need to increase efficiency and productivity of agricultural output also rises. This calls for innovative and cost-effective methods for improving plant growth and yield. Here we explore how antioxidants, molecules that inhibit oxidation and are necessary for redox based signaling and redox homeostasis, can be utilized as chemical biostimulants. Specifically, we investigated Coenzyme M, an antioxidant from archaea that holds potential economic advantages over other antioxidants. Chapter 1 provides a comprehensive review of antioxidants and how exogenously application of them affects plant growth and biology, highlighting the …


Under Pressure: A Rare Presentation Of Crude Oil Injection Injury To The Foot Secondary To Pressure Washer Injury, Stephanie N. Campbell, Heather V. Tran, Nikita V. Gambhir, Connor Krolikowski Mar 2025

Under Pressure: A Rare Presentation Of Crude Oil Injection Injury To The Foot Secondary To Pressure Washer Injury, Stephanie N. Campbell, Heather V. Tran, Nikita V. Gambhir, Connor Krolikowski

School of Podiatric Medicine Publications

No abstract provided.


Data Reporting Quality And Semantic Interoperability Increase With Community-Based Data Elements (Codes). Analysis Of The Open Data Commons For Spinal Cord Injury (Odc-Sci), Anushka Sheoran, Kenneth A. Fond, Lex Maliga Davis, J. R. Huie, Romana Vavrek, P. J. Axtman, Vance P. Lemmon, John L. Bixby, Ubbo Visser, John C. Gensel, Karim Fouad, Adam R. Ferguson, Jeffrey S. Grethe, Anita Bandrowski, Maryann E. Martone, Abel Torres-Espin Mar 2025

Data Reporting Quality And Semantic Interoperability Increase With Community-Based Data Elements (Codes). Analysis Of The Open Data Commons For Spinal Cord Injury (Odc-Sci), Anushka Sheoran, Kenneth A. Fond, Lex Maliga Davis, J. R. Huie, Romana Vavrek, P. J. Axtman, Vance P. Lemmon, John L. Bixby, Ubbo Visser, John C. Gensel, Karim Fouad, Adam R. Ferguson, Jeffrey S. Grethe, Anita Bandrowski, Maryann E. Martone, Abel Torres-Espin

Neurology Faculty Publications

Data interoperability is crucial for effectively combining data for scientific inquiry. To facilitate interoperability, data standards such as a common definition of variables are often developed. The Open Data Commons for Spinal Cord Injury (odc-sci.org) has established an initial set of community-based data elements (CoDEs)—a minimal set of variables for sharing—to promote data interoperability in SCI research, aligning with FAIR (Findable, Accessible, Interoperable, and Reusable) data principles. We sought to understand the use of CoDEs by the SCI community to inform current standards adherence and future standards development. We systematically analyzed 39 public datasets in relation to 17 required CoDEs …


Sociodemographic Factors Associated With Prenatal Care Utilization In Arkansas, United States., Pearl A Mcelfish, Aaron Caldwell, Donya Watson, Jonathan Langner, Jennifer Callaghan-Koru, Austin Porter, Don E Willis, Jennifer A Andersen, Nicola L Hawley, James P Selig, Amir Forati, Maria R Alcala, Lanita White, Enrique Gomez-Pomar, Clare C Brown Mar 2025

Sociodemographic Factors Associated With Prenatal Care Utilization In Arkansas, United States., Pearl A Mcelfish, Aaron Caldwell, Donya Watson, Jonathan Langner, Jennifer Callaghan-Koru, Austin Porter, Don E Willis, Jennifer A Andersen, Nicola L Hawley, James P Selig, Amir Forati, Maria R Alcala, Lanita White, Enrique Gomez-Pomar, Clare C Brown

Pediatrics Faculty Publications

OBJECTIVES: This study examines prenatal care utilization differences in Arkansas.

METHODS: Birth records data from the National Center for Health Statistics were used. The study population consisted of singleton live births in Arkansas from 2014 to 2022. Primary outcomes included number of prenatal visits, fewer than the recommended number of prenatal visits, late prenatal care, and no prenatal care. Summary statistics were computed, and adjusted rates ratios were calculated adjusting for maternal age, maternal education, and parity for payer, race/ethnicity, and rural/urban residence.

RESULTS: Mothers with a Medicaid-covered birth had 0.90 times fewer prenatal care visits and were 1.26 times …


Sociodemographic Factors Associated With Prenatal Care Utilization In Arkansas, United States., Pearl A Mcelfish, Aaron Caldwell, Donya Watson, Jonathan Langner, Jennifer Callaghan-Koru, Austin Porter, Don E Willis, Jennifer A Andersen, Nicola L Hawley, James P Selig, Amir Forati, Maria R Alcala, Lanita White, Enrique Gomez-Pomar, Clare C Brown Mar 2025

Sociodemographic Factors Associated With Prenatal Care Utilization In Arkansas, United States., Pearl A Mcelfish, Aaron Caldwell, Donya Watson, Jonathan Langner, Jennifer Callaghan-Koru, Austin Porter, Don E Willis, Jennifer A Andersen, Nicola L Hawley, James P Selig, Amir Forati, Maria R Alcala, Lanita White, Enrique Gomez-Pomar, Clare C Brown

Pediatrics Faculty Publications

OBJECTIVES: This study examines prenatal care utilization differences in Arkansas.

METHODS: Birth records data from the National Center for Health Statistics were used. The study population consisted of singleton live births in Arkansas from 2014 to 2022. Primary outcomes included number of prenatal visits, fewer than the recommended number of prenatal visits, late prenatal care, and no prenatal care. Summary statistics were computed, and adjusted rates ratios were calculated adjusting for maternal age, maternal education, and parity for payer, race/ethnicity, and rural/urban residence.

RESULTS: Mothers with a Medicaid-covered birth had 0.90 times fewer prenatal care visits and were 1.26 times …


Viral Detection In Anterior Nasal Swabs Versus Nasopharyngeal Swabs In Children, Nicole Neeley, Abby Kietzman, Rangaraj Selvarangan, Dithi Banerjee, Jennifer Goldman, Jennifer Schuster Mar 2025

Viral Detection In Anterior Nasal Swabs Versus Nasopharyngeal Swabs In Children, Nicole Neeley, Abby Kietzman, Rangaraj Selvarangan, Dithi Banerjee, Jennifer Goldman, Jennifer Schuster

Posters

Background: Respiratory viruses are a significant cause of pediatric illness and healthcare utilization. Diagnostic testing for respiratory viruses is generally performed using nasopharyngeal (NP) specimens obtained by trained medical staff, limiting testing to medical settings. Evaluating additional sampling methods in children, such as anterior nasal swab (NS) specimens may expand access to diagnostic testing and aid public health surveillance. Methods: Eligible children hospitalized at Children’s Mercy Hospital in Kansas City who had a standard of care NP specimen collected for nucleic acid amplification testing for respiratory viruses were enrolled. Research NS specimens were obtained through self, caregiver, or staff collection. …


Post-Operative Pain After Non-Surgical Root Canal Treatment With A Single Cone/ Bio-Ceramic Sealer Based Obturation: A Randomized Clinical Trial, Shehabeldin Mohamed Saber Prof.Dr. Mar 2025

Post-Operative Pain After Non-Surgical Root Canal Treatment With A Single Cone/ Bio-Ceramic Sealer Based Obturation: A Randomized Clinical Trial, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: compare the post- operative pain associated with sealer-based obturation technique (SBO) using bioceramic sealer and a (CWC) obturation technique with a resin-based sealer.

Materials and methods: two-arm randomized clinical trial with 2 parallel groups 20 patients each, after shaping the canals to a minimum dimension of 30/.04, except for a single middle mesial canal, which was shaped to 25/.04 patients randomly allocated into two groups based on the obturation material used. To ensure patient privacy, each name was replaced with a case number. Patients documented their pain on a 0–10 (VAS) at: 4 hours, one day, and two days …


Intracanal Microbial Reduction After Root Canal Preparation With Different Tapered Instruments. An Ex-Vivo Study, Shehabeldin Mohamed Saber Prof.Dr. Mar 2025

Intracanal Microbial Reduction After Root Canal Preparation With Different Tapered Instruments. An Ex-Vivo Study, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: The objective of this ex vivo study was to assess the dual impact of instruments taper and irrigation activation methods on bacterial reduction in infected root canals.

Materials and methods:42 extracted human molar teeth were inoculated with Enterococcus faecalis for 2 weeks to develop a mature biofilm. The samples were divided into four experimental groups and two control groups. The experimental groups underwent root canal preparation using two different instruments: XP Shaper (taper 0.04) and Reciproc Blue R25 (taper 0.08). Additionally, two different activation methods were tested: mechanical (XP Finisher) and sonic (EDDY). Bacterial reduction was assessed using Colony …


Accuracy Of Endodontic Access Guides Printed By A Costefficient 3d Printer (An In-Vitro Study), Shehabeldin Mohamed Saber Prof.Dr. Mar 2025

Accuracy Of Endodontic Access Guides Printed By A Costefficient 3d Printer (An In-Vitro Study), Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: This study evaluated the precision and trueness of endodontic access guides fabricated using a cost-effective desktop LCD 3D

printer compared to a higher-cost SLA printer for guided endodontics.

Materials and methods: Thirty-two root canals from Nissin typodont teeth were divided into two groups: LCD and SLA. Virtual

planning was performed, and endodontic guides were fabricated using both 3D printing technologies. Pre-operative and postoperative

cone beam tomography (CBCT) scans were taken, and the linear deviation between the planned and actual access paths

was measured at two axial levels: the occlusal entry point and the canal orifice. Statistical analyses were conducted …


Evaluation Of Thymoquinone Cancer Chemo-Preventive Effect On Oral Leukoplakia: A Randomized Clinical Trial, Dalia Ghalwash, Fatheya Zahran Mar 2025

Evaluation Of Thymoquinone Cancer Chemo-Preventive Effect On Oral Leukoplakia: A Randomized Clinical Trial, Dalia Ghalwash, Fatheya Zahran

Dentistry

Aim: This randomized clinical trial aimed to investigate the chemo-preventive role of thymoquinone in Nigella sativa extract in managing oral leukoplakia clinically, histologically, and at the molecular level. Methods: A total of 48 patients with oral leukoplakia were randomly allocated to three groups; Group A received local muco-adhesive tablets with Nigella sativa extract in 10 mg/kg dose, for three months, Group B same intervention but with Nigella sativa extract in 5 mg/kg dose, and lastly Group C was the placebo group. The outcomes assessed were clinical improvement, histologic improvement (degree of dysplasia), and molecular biomarkers Ki-67 and caspase-3 by immunohistochemistry. …


Contraceptive Hormone Influences On The Role Of Primary Reinforcement And Reinforcer-Enhancement In Nicotine Self-Administration, Kathleen Robin Mcnealy Mar 2025

Contraceptive Hormone Influences On The Role Of Primary Reinforcement And Reinforcer-Enhancement In Nicotine Self-Administration, Kathleen Robin Mcnealy

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Hormonal contraceptives contain a synthetic estrogen (e.g., ethinyl estradiol/EE) and/or a synthetic progestin (e.g., levonorgestrel/LEVO) and can exacerbate nicotine intake. However, whether altered intake reflects changes in nicotine reinforcement or enhancement by nicotine of co-occurring reinforcers is unknown. This reinforcer-enhancement effect is evidenced in rats when nicotine self-administration is increased by the presence of a visual stimulus (VS) reinforcer. This dissertation examined the effects of EE and LEVO on nicotine reinforcement and reinforcer-enhancement in ovary-intact female Sprague-Dawley rats. Rats were implanted with a jugular catheter and assigned to receive daily injections of EE (Vehicle, 0.125 [Low], or 0.18 [High] μg/day; …


Rates Of Minimally Invasive Surgery After Introduction Of Robotic-Assisted Surgery For Common General Surgery Operations, Zhi Ven Fong, Elizabeth Wall-Wieler, Shaneeta Johnson, Richard Culbertson, Brian Mitzman Mar 2025

Rates Of Minimally Invasive Surgery After Introduction Of Robotic-Assisted Surgery For Common General Surgery Operations, Zhi Ven Fong, Elizabeth Wall-Wieler, Shaneeta Johnson, Richard Culbertson, Brian Mitzman

School of Public Health Faculty Publications

Importance: Many patients who would benefit from minimally invasive surgery (MIS) have open surgery; robotic-assisted surgery (RAS) addresses some of the limitations of laparoscopic surgery and could increase rates of MIS across different patient populations. Objective: To determine whether the introduction of RAS increases MIS rates and whether increases are seen across different patient populations undergoing common general surgery procedures. Design: A retrospective cohort study was performed to compare rates of MIS in the year before and after the index date for hospitals that did and did not introduce RAS. Generalized estimating equation regression models were used to compare rates …


Clinical And Polysomnographic Analysis Of Lvhn Narcolepsy Cohort, Rena Y Jiang, Martina Vendrame Md, Phd, Roger Rochart, Irene Chu Mph, Md, Shae Duka Mph Mar 2025

Clinical And Polysomnographic Analysis Of Lvhn Narcolepsy Cohort, Rena Y Jiang, Martina Vendrame Md, Phd, Roger Rochart, Irene Chu Mph, Md, Shae Duka Mph

USF-LVHN SELECT

No abstract provided.


How Do Language Barriers Affect Diagnosis And Treatment Of Miscarriages In The Emergency Department?, Natalie Burkert, Patricia L. Maran Md Mar 2025

How Do Language Barriers Affect Diagnosis And Treatment Of Miscarriages In The Emergency Department?, Natalie Burkert, Patricia L. Maran Md

USF-LVHN SELECT

No abstract provided.


Improving Postpartum Diabetes Screening For Patients Diagnosed With Gdm, Julia Cheng, Lindsey Martinez Md, Faris Albakaa Md, Nicole M. Burgess, Autumn Kieber-Emmons Md, Mph Mar 2025

Improving Postpartum Diabetes Screening For Patients Diagnosed With Gdm, Julia Cheng, Lindsey Martinez Md, Faris Albakaa Md, Nicole M. Burgess, Autumn Kieber-Emmons Md, Mph

USF-LVHN SELECT

No abstract provided.


A Quality Improvement Approach To Decrease Primary Cesarean Deliveries At One Health Network, Jeannez Daniel, Joanne Quiñones Md, Msce, Kay Young Msn, Rnc-Ob, Jennifer Heibig Do, Amanda B. Flicker Md Mar 2025

A Quality Improvement Approach To Decrease Primary Cesarean Deliveries At One Health Network, Jeannez Daniel, Joanne Quiñones Md, Msce, Kay Young Msn, Rnc-Ob, Jennifer Heibig Do, Amanda B. Flicker Md

USF-LVHN SELECT

No abstract provided.


Growth Of Medical Schools In The United States: Its Potential Influence On Students Applying For Urology, Umberto Donato, David Nelwan, Ahmad Imam, Dominique Ebedes, Trushar Patel Mar 2025

Growth Of Medical Schools In The United States: Its Potential Influence On Students Applying For Urology, Umberto Donato, David Nelwan, Ahmad Imam, Dominique Ebedes, Trushar Patel

USF-LVHN SELECT

No abstract provided.


Implementation And Evaluation Of Disability-Focused Educational Initiatives, Nora Newcomb, Aishwarya Vuppala, Shannon Mccarthy, Emily Coughlin, Abigail Weisse, Maggie Fitzsimmons, Franklin Sun, Kyle Lien, Anita Varkhede, Andrew Galligan, Priya Chandan, Emily Noonan, Peyton Purcell, Rahul Mhaskar, Vinita Kiluk Mar 2025

Implementation And Evaluation Of Disability-Focused Educational Initiatives, Nora Newcomb, Aishwarya Vuppala, Shannon Mccarthy, Emily Coughlin, Abigail Weisse, Maggie Fitzsimmons, Franklin Sun, Kyle Lien, Anita Varkhede, Andrew Galligan, Priya Chandan, Emily Noonan, Peyton Purcell, Rahul Mhaskar, Vinita Kiluk

USF-LVHN SELECT

No abstract provided.


Mass Carbon Monoxide Poisoning At A Daycare: A Public Health Lesson, Christopher Popiolek, Kenneth D. Katz Md, Putt Vithayaveroj, Chase Jones Do, Natalie E. Ebeling-Koning Do, John Delbianco Md, Alexandra Amaducci Do, Susan K. Yaeger Md, Gillian A. Beauchamp Md Mar 2025

Mass Carbon Monoxide Poisoning At A Daycare: A Public Health Lesson, Christopher Popiolek, Kenneth D. Katz Md, Putt Vithayaveroj, Chase Jones Do, Natalie E. Ebeling-Koning Do, John Delbianco Md, Alexandra Amaducci Do, Susan K. Yaeger Md, Gillian A. Beauchamp Md

USF-LVHN SELECT

No abstract provided.


Breast Implant Salvage Rate Following Percutaneous Drainage For Periprosthetic Infection, Caitlin Read, Samantha Delapena Md, Aaron Jacobs Md, Nathan F. Miller Mar 2025

Breast Implant Salvage Rate Following Percutaneous Drainage For Periprosthetic Infection, Caitlin Read, Samantha Delapena Md, Aaron Jacobs Md, Nathan F. Miller

USF-LVHN SELECT

No abstract provided.


Improving The Diagnostic Algorithm Of Pulmonary Nodules Undergoing Tissue Sampling, Austin Retzloff, Daniel Schwed-Lustgarten Md Mar 2025

Improving The Diagnostic Algorithm Of Pulmonary Nodules Undergoing Tissue Sampling, Austin Retzloff, Daniel Schwed-Lustgarten Md

USF-LVHN SELECT

No abstract provided.


The Narcan Project: Impact Of Opioid Overdose Response Training On Medical Students’ Knowledge And Confidence, Putt Vithayaveroj, Emily Luo, Rithvic Jupudi, Nishanth Chalasani, Nathan Einhorn, Rebecca Lipscomb, Jennifer Costa Mar 2025

The Narcan Project: Impact Of Opioid Overdose Response Training On Medical Students’ Knowledge And Confidence, Putt Vithayaveroj, Emily Luo, Rithvic Jupudi, Nishanth Chalasani, Nathan Einhorn, Rebecca Lipscomb, Jennifer Costa

USF-LVHN SELECT

No abstract provided.


Assessment Of Parents’ Awareness About The Care Of Their Neonates With Neural Tube Defects, Asmaa Salah Khamis, Hayam Salah Tanatwy, Safaa Salah Ismail Mar 2025

Assessment Of Parents’ Awareness About The Care Of Their Neonates With Neural Tube Defects, Asmaa Salah Khamis, Hayam Salah Tanatwy, Safaa Salah Ismail

Nursing

Background: Neural Tube Defects are one of the most congenital anomalies of the Central Nervous System that may happen in the neonatal period. Aim of the study: this study aimed to assess parents’ awareness about the care of their neonates with neural tube defects. Research design: A descriptive study design was used. Setting: the study was conducted at the outpatient clinic for pediatric Neurology at Ain Shams Educational Hospital. Methods: A convenient sample of 40 parents accompanied by their neonates who suffered from neural tube defects. Tools: Data was collected using three tools. Tool (I) A structured questionnaire sheet composed …


A Study Of Secondary Traumatic Stress In Health Care Professionals In Long-Term Care., Bethany Proudfoot Mar 2025

A Study Of Secondary Traumatic Stress In Health Care Professionals In Long-Term Care., Bethany Proudfoot

Doctor of Social Work Capstone Projects

Secondary traumatic stress (STS) is a significant concern for healthcare professionals in long-term care (LTC) settings. This study explores the impact of STS on clinical staff, addressing the research question: How has STS affected employees within the LTC sector, and what resources or support can be provided to mitigate its effects? The study utilized a mixed-methods approach, combining survey data from clinical staff across five LTC facilities in Ohio, incorporating the survey data measuring levels of STS and qualitative responses. Findings revealed that 64% of participants experienced high to severe levels of STS, with symptoms including anxiety, depression, sleep disturbances, …


A Hot Topic: Standardization Of Fire Safety Training In Perioperative Areas, Megan Benner Msn-Ed, Rn, Cpan, Npd-Bc Mar 2025

A Hot Topic: Standardization Of Fire Safety Training In Perioperative Areas, Megan Benner Msn-Ed, Rn, Cpan, Npd-Bc

MaineHealth Maine Medical Center

Introduction: Fires in perioperative areas, while rare, are considered high-risk events. Up to 650 fires occur in the operating room annually in the United States with head and neck procedures having the highest rate of injury and mortality.


Insulin Receptor Responsiveness Governs Tgfβ-Induced Hepatic Stellate Cell Activation: Insulin Resistance Instigates Liver Fibrosis, Wang-Hsin Lee, Evelyn A. Bates, Zachary A. Kipp, Sally Pauss, Genesee J. Martinez, Cheavar A. Blair, Terry D. Hinds Jr. Mar 2025

Insulin Receptor Responsiveness Governs Tgfβ-Induced Hepatic Stellate Cell Activation: Insulin Resistance Instigates Liver Fibrosis, Wang-Hsin Lee, Evelyn A. Bates, Zachary A. Kipp, Sally Pauss, Genesee J. Martinez, Cheavar A. Blair, Terry D. Hinds Jr.

Markey Cancer Center Faculty Publications

The insulin receptor (INSR) has been shown to be hyperactive in hepatic stellate cells (HSCs) in humans and rodents with liver fibrosis. To explore HSC cellular mechanisms that INSR regulates during pro-fibrotic stimulation, we used CRISPR-Cas9 technology. We knocked out a portion of the INSR gene in human LX2 HSC cells (INSRe5- 8 KO) that regulates insulin responsiveness but not the insulin-like growth factor (IGF) or transforming growth factor-β (TGFβ) signaling. The INSRe5- 8 KO HSCs had significantly higher cell growth, BrdU incorporation, and lower TP53 expression that suppresses growth, and they also exhibited increased migration compared to the Scramble …


Lc-Ms Analysis Of Serum Lipidomic And Metabolomic Signatures In Pediatric Patients With Acute Lymphoblastic Leukemia, Feiyu Yan, Shengnan Wang, Yilin Wang, Yan Sun, Jing Yang, Lirong Sun, Yekaterina Y. Zaytseva, Pan Deng, Lingzhen Wang Mar 2025

Lc-Ms Analysis Of Serum Lipidomic And Metabolomic Signatures In Pediatric Patients With Acute Lymphoblastic Leukemia, Feiyu Yan, Shengnan Wang, Yilin Wang, Yan Sun, Jing Yang, Lirong Sun, Yekaterina Y. Zaytseva, Pan Deng, Lingzhen Wang

Markey Cancer Center Faculty Publications

Background Acute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy that primarily affects children. The diagnosis and treatment of pediatric ALL remain challenging. This study aimed to identify differential lipids and metabolites that may hold potential for improving ALL treatment.

Methods In this retrospective case-control study, serum samples obtained from children with ALL and healthy controls were analyzed. Serum lipidome and metabolome alterations of ALL were analyzed by comparing pediatric patients with ALL with healthy controls based on liquid chromatography high-resolution mass spectrometry analysis of serum lipidomic and metabolomic signatures.

Results We identified 2,298 lipid features in the serum. Among …


Exploring Oxylipins In Host–Microbe Interactions And Their Impact On Infection And Immunity, Robert J. Neff, Christopher D. Radka Mar 2025

Exploring Oxylipins In Host–Microbe Interactions And Their Impact On Infection And Immunity, Robert J. Neff, Christopher D. Radka

Markey Cancer Center Faculty Publications

Plasma lipids are essential components of biological systems, transported through interactions with proteins to maintain cellular functions. These lipids exist in various forms, such as fatty acids, glycerolipids, glycerophospholipids, sphingolipids, sterols, and prenol lipids, derived from dietary intake, adipose tissue, and biosynthesis. While the association between certain fatty acids and cardiovascular diseases has been widely recognized, polyunsaturated fatty acids (PUFAs) exhibit cardioprotective effects, reducing risks of arrhythmias and heart-related mortality. This is due to their role in the production of eicosanoids, which modulate inflammation. Chronic inflammation, particularly in obesity, is significantly influenced by fatty acids, with saturated fatty acids promoting …