Medicine and Health Sciences Commons^™

Identification Of Xanthine Oxidase Inhibitors In Single-Clove Black Garlic Using Metabolomics And Molecular Docking Approaches, Abdul Aziz Setiawan, Shirly Kumala, Dian Ratih Laksmitawati, Ari Yuniarto, Nancy Dewi Yuliana

Makara Journal of Science

Black garlic is produced through controlled fermentation under specific temperature and humidity conditions, during which the Maillard reaction enhances its sensory properties and bioactivity. The anti-hyperuricemic potential of single-clove black garlic (SBG) remains unexplored. This study combined Ultra High-Performance Liquid Chromatography–High Resolution Mass Spectrometry-based metabolomics and an in-silico approach to identify the potential xanthine oxidase inhibitors (XOI) in SBG. Methanolic extracts (10 ppm) exhibited xanthine oxidase inhibition ranging from 50.09% to 68.01%, which is comparable to allopurinol (78.74%) at the same concentration. Metabolomic profiling tentatively identified 45 compounds, and orthogonal partial least squares analysis revealed seven metabolites as strongly correlated …

Dna Methylation In Periodontal Disease: A Focus On Folate, Folic Acid, Mitochondria, And Dietary Intervention, Elzbieta Pawlowska, Joanna Szczepanska, Marcin Derwich, Piotr Sobczuk, Nejat Düzgüneş, Janusz Blasiak

Pacific Faculty Work

Although periodontal disease (PD) is reported to be associated with changes in various genes and proteins in both invading bacteria and the host, its molecular mechanism of pathogenesis remains unclear. Changes in immune and inflammatory genes play a significant role in PD pathogenesis. Some reports relate alterations in cellular epigenetic patterns to PD characteristics, while several high-throughput analyses indicate thousands of differentially methylated genes in both PD patients and controls. Furthermore, changes in DNA methylation patterns in inflammation-related genes have been linked to the efficacy of periodontal therapy, as demonstrated by findings related to the cytochrome C oxidase II gene. …

The Influence Of Tobacco Use, Hazardous Drinking, And Other Risk Factors On Hpv-Associated Oropharyngeal Cancer Risk And Screening Perceptions Among Gay And Bisexual Men: A Cross-Sectional Study, I Niles Zoschke, Sarah L Bennis, Yi Tang, J Michael Wilkerson, Cynthia L Stull, Alan G Nyitray, Samir S Khariwala, C Mark Nichols, B R Simon Rosser, Charlene A Flash, Michael W Ross

Faculty, Staff and Student Publications

Background: Oropharyngeal cancer is the eighth most common cancer among US men and its incidence is sharply rising. Oropharyngeal cancer manifests in two major ways: the classic form is prevalent among people who use alcohol and tobacco heavily, while a growing subset of incident cases is associated with human papillomavirus-16 (HPV) and transmitted via oral sex. Gay and bisexual men appear at higher risk for each etiologic subset of oropharyngeal cancer than heterosexual men. We conducted a cross-sectional study to learn how tobacco use, hazardous drinking, and other key risk factors affect gay and bisexual men's perceptions of oropharyngeal cancer …

Outcomes Of Surgically Implanted Impella Microaxial Flow Pumps In Heart Failure-Related Cardiogenic Shock, Jacob Abraham, Mark Anderson, Scott Silvestry, Edward G Soltesz, Masahiro Ono, Kanika Mody, Fardad Esmailian, Arman Kilic, Rupinder Bharmi, Rothy Chhim, Roberta Bogaev-Chapman, Gundars J Katlaps, Ismael Salas De Armas, Mani A Daneshmand, David J Kaczorowski, Duc Thinh Pham, Danny Ramzy, David D'Alessandro

Faculty, Staff and Student Publications

Background: Patients with cardiogenic shock (CS) are increasingly treated with high-profile microaxial flow pumps (Impella 5.5), but little is known about the indications and outcomes of this support strategy in patients with CS due to heart failure (HF-CS).

Objectives: We sought to describe the clinical features and outcomes of patients with HF-CS treated with Impella 5.5.

Methods: We analyzed data from a prospective, multicenter observational study of patients with CS who had been implanted with an Impella 5.5. Adverse events, in-hospital survival rates and 6- and 12-month survival rates were analyzed in the total cohort and between patients treated with …

Psychological Influence Of Acne Vulgaris Among Female Students Of University Of Poonch Rawalakot Azad Jammu And Kashmir, Pakistan, Faryal Hanif, Ahmed Hussain, Ehsan Ali, Muhammad Rasheed

Journal of Bioresource Management

This study aimed to assess the prevalence of acne vulgaris among female students at the University of Poonch, Rawalakot, and to evaluate its impact on their quality of life using the Dermatology Life Quality Index (DLQI). A cross-sectional survey was conducted from July to August 2022, involving a total of 2000 female students. Out of these, 400 individuals were clinically diagnosed with acne vulgaris, indicating a prevalence rate of 20 %. The participants completed the DLQI questionnaire, which evaluates the psychological and social effects of dermatological conditions. The data obtained were analyzed to assess the influence of acne on various …

Study On Predisposing Factors And Control Measures Against Cryptosporidiosis In Buffalo Calves At Cattle Colony Hyderabad, Sindh, Pakistan, Ali Ul Murtaza, Abdul Latif Bhutto, Jam Kashif Zaman, Mansoor Tariq, Amjad Hussain Mirani, Riaz Ahmed Laghari, Pervez Ahmed Khoso, Muhammad Mohsen Rahimoon, Abdul Saboor, Fayaz Hussain

Journal of Bioresource Management

The current study looked at the variables affecting the frequency of Cryptosporidium Parvum in buffalo calves at the Hyderabad Cattle Colony. From calves, 100 fecal samples were taken in total, preserved, and analyzed using direct smear and Ziehl-Neelsen staining methods. 74 percent of the samples tested positive for Cryptosporidium Parvum. Disease rates were higher in Nili Ravi calves (86 %) compared to Kundhi calves (62 %), with a statistically significant difference (p

Review On Treatment Outcome Of Patient With Acute Bacterial Meningitis In Pediatrics, Uswa Insaf, Faiza Waseem, Nadia Iqbal, Tehseen Riaz, Irfan Bashir, Waqas Akram

Journal of Bioresource Management

Antibiotic treatment improves outcomes of treatment, but extensively available antibiotics efficiency is vulnerable by globally appearance of development of multidrug-resistant bacteria. An infectious etiology arises, such as fungi, bacteria, viruses, mycobacteria, or parasites, or be related with cancer, autoimmunity, or medications reaction. The causative organism was recognized by most patients treated with antibiotics, culture of the CSF and blood, by countercurrent immune-electrophoresis of fluids. Neisseria meningitidis, Hemophilus influenzae b and Streptococcus pneumoniae are the commonest causes of bacterial meningitis. Bacterial meningitis has adequately extreme in the pediatrics people of developing countries. Many people with bacterial meningitis don't have any …

Video Discharge Instructions Increase Patient Understanding For Office-Based Procedures: A Randomized Controlled Study, Jenna Bates Maffei, Jeffrey J Song, Gal Saffati, Mohit Khera

Faculty, Staff and Students Publications

Background: Health literacy significantly influences healthcare outcomes, with poor literacy leading to worse quality of life, increased mortality, and higher readmission rates. Recent efforts to improve post-encounter education include structured teach-back methods, patient preference assessments, and standardized discharge instructions. Studies in emergency departments have shown that incorporating video discharge instructions enhances patient understanding and retention of care information. To address the gap in urology, this study aims to evaluate patient comprehension and satisfaction with video discharge instructions following clinic-based vasectomy procedures.

Methods: We performed an Institutional Review Board approved (#H-51614) unblinded randomized controlled study with written consent from each participant. …

The Impact Of Cyber Victimization On Adolescent Mental Health, Sherri Ann Walker, Folashade Odedina

Mental Health Summit

Cyber victimization is a growing risk factor for mental health disorders among adolescents. This session explores its prevalence and impact on adolescent well-being, as well as evidence-based interventions to mitigate harm. Attendees will learn strategies for screening, risk assessment, and promoting protective factors with an integrated Christian perspective on supporting affected youth.

Ambiguous Loss In Perinatal Period: Mental Health Consequences, Rachel Joseph, Mary Highton

Mental Health Summit

Ambiguous loss (AL) occurs when grief lacks closure, such as in cases where a loved one is physically or emotionally absent. In this session, we’ll be discussing the impact of AL on parents of premature babies and how NICU nurses play a crucial role in recognizing grief, providing support, and using a holistic approach to promote parents’ long-term well-being

Autism Spectrum Disorder Diagnosis And Treatment Updates, Olubukola Ojuola

Mental Health Summit

This session provides an overview of the latest updates in diagnosing and treating Autism Spectrum Disorder (ASD), emphasizing early detection and individualized interventions. Attendees will explore assessment tools, evidence-based treatments, and emerging research on genetics and neurobiology. The presentation also highlights the critical role of family support and community resources in improving outcomes for individuals with ASD.

Integration Of A Biopsychosociospiritual Model In Mental Health Treatment Resistance, Sherri Ann Walker, Folashade Odedina

Mental Health Summit

Treatment resistance in mental health is a growing concern due to misdiagnosis, medication issues, socioeconomic barriers, and more. This presentation will cover a biopsychosocial model, addressing faith, existential concerns, and hope, expanding treatment approaches, and putting an emphasis on treatment resistance and holistic strategies to enhance patient outcomes and well-being.

Combating Compassion Fatigue Using Mindfulness Techniques, Christie Baker, Summer Cross

Student Scholarship & Creative Works

Demands placed on health care professionals have steadily increased and as a result, compassion fatigue has become an issue by adversely affecting the well-being of nurses and health care organizations. Compassion fatigue is a widely accepted phenomenon in nursing, creating an array of physical and emotional manifestations, impairing a health care provider’s ability to provide optimum quality care. The goal of this quality improvement project aimed to educate and provide emergency room nurses with a resource for self-care enhancement to subsequently decrease their risk of developing compassion fatigue. Nurses of a small, rural emergency department located in the southeastern region …

Ai Made Simple: A Practical Guide For Pt Practice, Stacie Mae Larreau Christensen, Brad Dexter, Megan Frazee

Posters and Presentations: Physical Therapy

No abstract provided.

Impact Of Using The Multi-Ethnic Global Lung Initiative As A Spirometry Reference Equation: Retrospective Cross-Sectional Study In Egyptians, Mohamed Gs. El-Shiekh

Journal of Medicine in Scientific Research

Context: Spirometry interpretation is largely affected by the reference equation. European Coal and Steel Community/European Respiratory Society reference equation 93 (ECSC-ERS93) is widely used in Egypt, despite the endorsement of multiethnic global lung initiative equation (GLI-2012) by many international societies as a reference. Aim: We aimed to investigate the interpretive impact of shifting from ECSC-ERS93 to GLI-2012 among Egyptians. Methods: Acceptable pre-bronchodilator spirometry tests for Egyptian subjects, obtained between January 2022 and July 2024 were included, excluding those with age and anthropometric limits of ECSC-ERS 93 equation. Interpretation of spirometric results (normal, preserved ratio impaired spirometry (PRISm), spirometric obstruction, spirometric …

Cytosimplex: Visualizing Single-Cell Fates And Transitions On A Simplex, Jialin Liu, Yichen Wang, Chen Li, Yichen Gu, Noriaki Ono, Joshua Welch

Faculty, Staff and Student Publications

Summary: Cells differentiate to their final fates along unique trajectories, often involving multi-potent progenitors that can produce multiple terminally differentiated cell types. Recent developments in single-cell transcriptomic and epigenomic measurement provide tremendous opportunities for mapping these trajectories. The visualization of single-cell data often relies on dimension reduction methods such as UMAP to simplify high-dimensional single-cell data down to an understandable 2D form. However, these dimension reduction methods are not constructed to allow direct interpretation of the reduced dimensions in terms of cell differentiation. To address these limitations, we developed a new approach that places each cell from a single-cell dataset …

Proximal Hamstring Strain - Current State Of Practice, Mike Wellsandt

Posters and Presentations: Physical Therapy

No abstract provided.

The 4-Element Movement System Model, Applications For Clinical Instructors And Novice Clinicians, Elizabeth Wellsandt, Sara E. Bills, Stacie Mae Larreau Christensen

Posters and Presentations: Physical Therapy

No abstract provided.

Novel Drug Approvals 2024, Hanh Motilall, Kelley Maberry, Connor Quinter

Transformative Medicine

In 2024, the Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CEDR) approved 50 new drugs. As healthcare professionals, staying up to date on new therapies is vital. There are a wide range of medications that fall into several categories; therefore every professional can find a medication that pertains to their field. Three medications in particular will be described in detail outlining their background, the clinical trials highlighting their efficacy and safety, and lastly the prescribing information. The three medications are as follows, Xanomeline/Trospium Chloride (Cobenfy),Sotatercept-csrk (Winrevair) and Suzetrigine (Journavx).

Xanomeline/trospium chloride (Cobenfy) is a first of …

Premature Atrial Complexes: A Minor Nuisance Or A Major Concern?, Jaswanth Jasti, Muhammad Asad Hanif, Tirumala Nischal Jasty, Muhammad Mohsin Zafar

Transformative Medicine

No abstract provided.

Effect Of Traditional Architecture And New Urbanism On Public Health: A Medical Perspective, Eron J. Powell, Jeremy R. Ellis

Transformative Medicine

No abstract provided.

Embracing Imperfection: Medical Students’ Perspectives On Pass/Fail Curricula In Medical Education, Jeremy R. Ellis, Luke M. Tomasovic, Rachel L. Marcheskie

Transformative Medicine

No abstract provided.

The Effects Of Dexmedetomidine On Nausea And Vomiting In Intraabdominal Surgical Patients, Sarah Mann

Scholars Week

Abstract

Purpose: Postoperative nausea and vomiting (PONV) affect a significant number of surgical patients. This Doctor of Nursing Practice project aimed to assess PONV rates and evaluate the effects of dexmedetomidine on PONV incidence in intraabdominal surgical patients. Additionally, the project sought to inform Certified Registered Nurse Anesthetists (CRNAs) about dexmedetomidine and assess the perceived value of this information through a survey.

Methodology: The retrospective analysis of 9,035 patients was conducted from January 2023 to July 2024. Data were divided into four datasets, and comparisons were made between the datasets to determine PONV rates and the effects of dexmedetomidine. The …

Ransomware In Healthcare: Threats, Impacts, And Mitigation Strategies, Mackenzie Dotson, Kasi Gorli, Alberto Coustasse

Management Faculty Research

Excerpt: The growing digitalization of healthcare has exposed hospitals to significant cybersecurity threats, particularly ransomware attacks. The Health Sector Cybersecurity Coordination Center (HC3) reported that as of mid-2024, there were 730 cyber-attacks worldwide against healthcare institutions, with 530 targeting the U.S. (AHA, 2024). Half of these incidents involved ransomware, a type of malware that restricts access to critical data until a ransom is paid (HHS, 2021). Hospitals are attractive targets for cybercriminals due to their essential role in patient care. Cybercriminals exploit vulnerabilities in hospital networks, often causing severe operational and financial damage. Factors such as understaffed IT teams, outdated …

Cyber Threats In Healthcare: The Ransomware Epidemic, Mackenzie Dotson, Kasi Gorli, Alberto Coustasse

Management Faculty Research

In this presentation, we will delve into the growing ransomware crisis in healthcare, examining how these cyber threats disrupt hospital operations, jeopardize patient safety, and impose significant financial burdens. From understanding how ransomware infiltrates hospital systems to exploring real-world case studies, we will uncover the devastating impact of these attacks. Our discussion will also focus on mitigation strategies, cybersecurity best practices, and policy recommendations to safeguard healthcare institutions from future threats.

Breakfast In Schools: Literature Review, Hannah C. Posey

Master of Nutrition and Dietetics

Breakfast is recommended as part of a healthy diet because it is associated with healthier macro and micronutrient intakes, BMI, and lifestyle. Breakfast is also widely promoted to improve cognitive function and academic performance (Hoyland et al., 2009). Yet, according to Hayes and FitzSimons (2024) in the 2021-2022 school year, 51.9 out of every 100 students picked up breakfast, while in the 2022-2023 school year that decreased to 50.9 out of every 100 students. That is a decrease of 1.2 million children for the school year not receiving school breakfast that had the year prior. Hearst et al. (2017) discovered …

Smart Radiology: Using Artificial Intelligence For Better Imaging Outcomes, Jordan Watts, Jeffrey Larson, Kasi Gorli, Alberto Coustasse

Management Faculty Research

We hypothesize that the use of Artificial Intelligence (AI) in radiology improves the quality of care by increasing diagnostic accuracy, reducing interpretation time, and enhancing clinical workflow efficiency by minimizing imaging acquisition errors.

Defining Sexual Assault, Consent, And Resources To Empower Students: A Dnp Project, Sarah Powers

SACAD: Scholarly Activities

Abstract

Sexual assault (SA) remains a pervasive issue on college campuses in the United States, often compounded by underreporting and a lack of knowledge about available resources. This Doctor of Nursing Practice (DNP) project aims to educate first-year college students about SA, sexual consent, and available resources to empower students in preventing assaults and seeking help when needed. The intervention, which was integrated into mandatory freshman seminars at a four-year university, was guided by Knowles' Adult Learning Theory. A presentation provided critical information, and knowledge gains were assessed through pre- and post-presentation surveys. Initial findings indicated significant increases in understanding …

Use Of Telemetry In A Non-Critical Care Setting, Edna A. Howerton

Walden Dissertations and Doctoral Studies

This clinical practice guideline (CPG) project was developed for best utilization of telemetry. In order to diagnose arrhythmias and ischemic changes in the heart, continuous cardiac monitoring or telemetry is crucial. The practice-focused question was, “Does the evidence support the development and quality scoring of a CPG using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument, that is also approved for use in the practice setting by end users?” The purpose of this doctoral project was to create a CPG to offer the best evidence for practice and optimal approaches to improve the effective utilization of …

Pedagogy, Technology Acceptance, And Technological Pedagogical Content Knowledge Among Nursing Faculty, Rachel Ross

USF Tampa Graduate Theses and Dissertations

Integrating pedagogical and technological knowledge among faculty is crucial, especially within Florida state colleges’ Nursing (ADN) programs. I explored the impact of three decades of technological advancements on faculty's ability to incorporate technology into their teaching methods using a qualitative, exploratory design; I conducted semi-structured interviews via Microsoft Teams. The analysis of faculty perceptions, experiences, and challenges reveals a significant gap in pedagogical knowledge despite strong subject matter expertise, indicating underdeveloped instructional strategies and learner-centered pedagogies. Additionally, participants exhibited a diverse understanding of the Technological Pedagogical Content Knowledge (TPACK) framework, highlighting difficulties in effectively integrating technology, pedagogy, and content knowledge. …