Medicine and Health Sciences Commons^™

Implementing Breast Milk Expression Education Protocol: A Quality Improvement, Brenda Balarezo

DNP Projects

Significance and Background: Prematurity related complications (PRC) are the second leading cause of death for children under the age of five. Breast milk (BM) contains bio-actives that reduce PRC. However, delayed BM expression (BME) reduces BM availability. Adherence to Baby Friendly Hospital Initiative’s recommendation for BME within 6 hours in mothers of neonatal intensive care unit (NICU) infants remain poor without a standardized BME protocol.

Purpose: To increase the percentage of NICU mothers initiating BME within 6 hours of birth. To educate labor and delivery nursing staff on early BME.

Methods: The Institute for Healthcare Improvement’s Model for Improvement Plan-Do-Study-Act …

Dentistry And The Law: Yes, Dentists (And The Mda) Are Subject To Antitrust Law, Daniel Schulte Jd

The Journal of the Michigan Dental Association

This legal article explains how antitrust laws apply to dentists and dental associations. It clarifies that violations occur when competitors agree to activities that unreasonably restrain competition. The article distinguishes between "per se" illegal activities (price-fixing, group boycotts, allocation of territories) and those evaluated under the "rule of reason." Specific examples of prohibited activities include agreements on fees, discount limitations, or refusals to participate with dental plans. Enforcement can come from the DOJ, FTC, state agencies, or private lawsuits, with penalties including imprisonment, fines, and treble damages.

Investigation Of The Effects Of The Peptidylarginine Deiminase Inhibitor Cl-Amidine On Apoptosis And Gene Expression In Ovarian Cancer, Victoria Walden

Longwood Senior Thesis Proposal

Peptidylarginine deiminases (PADs) are a family of enzymatic proteins responsible for the conversion of arginine and methylarginine residues to citrulline. This conversion is important for several key cellular processes including transcriptional gene regulation. Recently, a link has been established between overexpression of a particular PAD, PAD4, and the accelerated progression of both autoimmune diseases and cancers. Ovarian cancer exhibits heightened levels of PAD4 in affected cells. High levels of PAD4 are associated with the formation of neutrophil extracellular traps (NETs) that promote cancer metastasis, and downregulation of the p53 apoptotic pathway. Thus, it is important to explore inhibitors of PAD4. …

Associations Between B Vitamin Interactions With Polyunsaturated Fatty Acids And Cognitive Function Among Cognitively Healthy Older People As Modified By Amyloid Status And Sex, Chuliang Zhao, Karen A. Abbott, Chinedu Momoh, Geraint Price, Oliver J. K. Robinson, Sujin Kang, Celeste A. De Jager Loots

Brain and Mind Institute

Background/Objectives: Nutrients such as vitamin B12, folate (B9), and polyunsaturated fatty acids (PUFAs) may independently influence cognitive health, but their combined effects and interactions remain unclear. This study aims to investigate the effects of B12, folate, and PUFAs, including their interactions, on cognitive function in cognitively healthy older adults, considering effect modification by sex and amyloid-beta status.

Methods: A cross-sectional analysis was conducted using data from 321 participants aged 60–85 y enrolled in the UK CHARIOT–PRO SubStudy. Dietary intake was assessed using the Scottish Collaborative Group Food Frequency Questionnaire, and cognitive performance was measured via the Repeatable Battery …

The Effect Of A M-Health Application Compared To Standard Of Care On Adherence To Preoperative Fasting Instructions Among Adult Patients Undergoing Elective Surgery: A Randomized Controlled Study, Ivy Njeri Wanyoike

Master of Medicine in Anaesthesiology

Background: Preoperative fasting has been a pillar of the practice of anaesthesiology with the main aim of enhancing patient safety by reducing the risk of aspiration. Current clinical guidelines on preoperative fasting guidelines encourage shorter durations of fasting in keeping with current evidence that shows better patient outcomes while maintaining patient safety. Despite this, adherence to preoperative fasting instructions remains universally poor, with patients enduring long fasting periods. Advances in mobile technology, improving internet access and the widespread availability of smartphones have made mobile health a useful tool in patient care. mHealth applications are being increasingly used in perioperative …

Personal Development E-Portfolio Incorporating Digital Badges, Therese Murphy

Case studies: Digital Education

The BIOL 1900 Professional Skills module introduces students to the development of a Personal Development E-Portfolio, submitted via Brightspace Dropbox. This initiative, launched following a Year 1 programme review, aims to enhance the digital skills of the student cohort. The portfolio comprises two key Digital-related components: a Self-Assessment Digital Badge and enhancement of digital skills through participation in workshops and lectures, and online courses offered via TU Dublin digital badges. The Self-Assessment Digital Badge, accounting for 5% of the module, involves completing a self-assessment to evaluate digital capabilities using the JISC Discovery Tool, followed by submission of the badge and …

Evaluation Of Lc-Uv Data For Method Validation, Maeve Scott

Case studies: Digital Education

The module was co-delivered in face-to-face mode to three Science programmes (typically 70 students) in year three, many of whom apply to industries where the learning outcome of the video is a key competency. Analytical methods used in a regulated or accredited testing environment must be validated in line with international guidelines. A science graduate who intends to work in a pharmaceutical or related industry should understand how to interpret test results to demonstrate an analytical method is reliable and fit for purpose. A screen pal video was generated to support an introduction to the theory of method validation delivered …

An Interoperability Framework Across Legacy Emr Systems, Sheena Rogers

Translational Projects (Open Access)

The 21st Century Cures Act (H.R.34 – 114th Congress, 2016) specifies that patients and authorized providers must be able to receive copies of their medical records with standard medical history details upon request. While the data archival system, DRIS (Data Retention Interoperability Solution), has comprehensive patient summary reports centralizing over 100 legacy electronic health records (EHR) with broad data elements, it is not 100% compliant with the upcoming 21st Century Cures Act’s interoperability standards. As a result, patients and providers are not receiving copies of their medical records with all of the required medical history and fields in this new …

Strategies To Improve Nurse Documentation Compliance And Confidence In The Delivery Of Preprocedural Education, Danielle A. Burris

Doctor of Nursing Practice Final Project Abstract

Strategies to Improve Nurse Documentation Compliance and Confidence in the Delivery of Preprocedural Education:

Abstract

Introduction:This project aimed to implement tools to improve preprocedural education compliance between nurses and patients in an interventional radiology department. The secondary aim was increasing staff confidence in providing education, reducing the potential for avoidable harm and adverse procedural-related outcomes. The project was implemented within an interventional radiology department of a healthcare system in the Texas Medical Center, Houston, Texas.

Methodology: The project utilized the Model for Improvement and followed the steps of the Plan-Do-Study-Act cycle to implement change. Strategies included checklists, reminder tools, …

A Psychometric Validation Of The Neonatal Abstinence Syndrome: Exploring Neonatal Nurses' Attitudes, Knowledge, And Practice Tool, Megan A. Ventrello

Theses & Dissertations

Background:

The National Center for Drug Abuse Statistics estimates that as of 2020, 3.8% of American adults have abused opioids in their lifetime (Centers for Disease Control and Prevention, n.d.). In addition, around 7% of women self-reported that they were using opioid pain relievers during their pregnancy, and 1 in 5 of these women reported misusing these medications while pregnant (Centers for Disease Control and Prevention, 2022a; Ko, 2020). Women who use opioids throughout their pregnancy give birth to infants who are born with Neonatal Abstinence Syndrome. The symptoms can be marked by a signature high-pitched cry and inconsolability, making …

A Holistic Perspective On Pain Assessments, Focusing On The Multidimensional Measurement Of Comfort Levels: A Quantitative Analysis And Psychometric Evaluation Of The 13-Item Shortened General Comfort Questionnaire, Victoria A. Marner

Theses & Dissertations

Background: Pain is multidimensional. It is a physical, psychospiritual, environmental, and sociocultural experience (Ebrahimpour & Hoseini, 2018). Current measures of pain tend to be unidimensional, only focusing on the physical aspect of pain. The entire experience of pain may not be effectively communicated by patients or adequately controlled by interventions (e.g., analgesics, repositioning, physical therapy). Adults in pain may struggle to participate in daily activities and responsibilities. A scale encompassing all pain contexts and comfort levels could provide a more comprehensive view of the patient’s experience. Transitioning from measuring pain to measuring comfort holistically would provide patient satisfaction and improved …

Small-Molecule Mitotic Inhibitors As Anticancer Agents: Discovery, Classification, Mechanisms Of Action, And Clinical Trials, Yazmin Salinas, Subhash Chauhan, Debasish Bandyopadhyay

School of Medicine Publications

Despite decades of research, cancer continues to be a disease of great concern to millions of people around the world. It has been responsible for a total of 609,820 deaths in the U.S. alone in 2023. Over the years, many drugs have been developed to remove or reduce the disease’s impact, all with varying mechanisms of action and side effects. One class of these drugs is small-molecule mitotic inhibitors. These drugs inhibit cancer cell mitosis or self-replication, impeding cell proliferation and eventually leading to cell death. In this paper, small-molecule mitotic inhibitors are discussed and classified through their discovery, underlying …

Sox18 Unleashed: Exploring The Transcriptomic Landscape – Differential Gene Expression Analysis Via Rna Seq In Overexpressed Sox18, Van Nguyen, Terry Shackleford, Lori Boies

Posters - 2025

Cancer remains a leading cause of death worldwide, and childhood sarcomas such as Rhabdomyosarcoma (RMS) and Ewing Sarcoma (ES) are particularly aggressive with limited targeted treatment options. Despite advancements in cancer therapies, metastatic sarcomas still have a survival rate below 30%, emphasizing the need for new therapeutic targets. SOX18, a transcription factor has played a role in vascular development and endothelial differentiation, functioning as a key driver of angiogenesis. In cancer, increased SOX18 expression has been linked to dysregulated cell migration, invasion, and therapy resistance mechanisms. However, the extent to which SOX18 influences RMS and ES at the transcriptional level …

Maternal Obesity Alters Antigen-Bound Igg Levels In Breast Milk, G. Sophia Noriega, Andrea Paredes, Emma C. Colins, Elizabeth A. Leadbetter

Posters - 2025

• Maternal obesity is an increasingly prevalent condition worldwide that has been associated with adverse outcomes in offspring, including higher propensity to infection and elevated risk of immune-related disorders like asthma and allergies 1 .

• Breast milk contains a wide variety of immunological components that are essential for neonatal immune development. Among these, it contains immunoglobin G (IgG) immune complexes, which are formed by IgG bound to specific antigens2 .

• These immune complexes have been suggested to play a crucial role in antigen-specific immune response in breastfed infants3 , increasing oral tolerance and asthma prevention 4 .

• …

The Impact Of Employer-Provided Drug/Alcohol Education On Marijuana And Alcohol Use In Young Adults., Sonia Cerrillo, Naomi Ramirez

Posters - 2025

According to the American Society of Addiction Medicine, addiction is a treatable, chronic medical disease involving complex interactions among brain circuits, genetics, the environment, and an individual’s life experiences (1). People with addiction use substances or engage in behaviors that become compulsive and often continue despite harmful consequences. The most common addictions in the United States are alcohol and marijuana (2). In the U.S., 59.277 million people twelve and older have used illegal drugs or misused prescription drugs. Out of the 138.522 million Americans who overdrink alcohol, 28.32 million have an alcohol use disorder (3).

Since alcohol and drug abuse …

Spectroscopic And Electrochemical Properties Of Ugi Adducts Of Isatin, Callah Preti, Erick Y. Morales Orrante

Posters - 2025

• β-lactams are essential structural components of many antibiotics and widely studied due to their biological importance and synthetic versatility.

• The Ugi reaction is a multicomponent reaction involving: • Aldehyde, primary amine, carboxylic acid, and isocyanide.

• Rapidly generates α-acetamido carboxamide derivatives (Ugi adducts). • The study focuses on the synthesis and characterization of two oxindole-based β-lactam derivatives:

• 1-Benzyl-N-(tert-butyl)-2-oxo-3-(2-oxoazetidin-1-yl)indoline-3- carboxamide (4a).

• N-(tert-Butyl)-2-oxo-3-(2-oxoazetidin-1-yl)indoline-3- carboxamide (4d).

• Characterization methods included IR Spectroscopy, UV-Visible Spectroscopy, and X-Ray Crystallography.

• Future work will investigate metal complexation to enhance β-lactam stability, alter electronic properties, and improve biological activity

Examining The Features Of Former Research Regarding Substance Abuse Treatment, Autumn Gonzales

Posters - 2025

“Drug misuse is one of the major social, legal, and publichealth challenges in the modern world” (Nutt et al., 2007). This study explored the characteristics of former research on substance abuse treatment approaches and treatment settings. Past literature showed short-term treatment can be beneficial depending on what works best for the individual and studies have shown short-term treatment has helped individuals with Substance Use Disorder (SUD). However, long-term treatment is the preferred method for individuals as it has a lower chance of relapse. A small systematic review was conducted from which data were coded of former published articles. A frequency …

Evaluation Of Angiogenesis In An Ex-Ovo Chick Chorioallantoic Membrane (Cam) Assay To Study The Mmp9 Gene In Pediatric Cancer Cell Lines, Franchesca Tinacba, Kahlie Hernandez, Terry Jo Shackleford

Posters - 2025

Model organisms are widely utilized in cancer research due to their ability to allow researchers to study biological processes that occur within cancer progression. One model organism that is used is the Chorioallantoic Membrane (CAM) assays. Chicken embryos are a sufficient model that are used to study processes such as angiogenesis, tumor growth, and drug effects. What makes these models useful is due to the cost efficiency, accessibility, and the increased speed the blood vessels can grow. Despite the results, it can be difficult to image the results or monitor the CAM assay. That is why Ex-ovo CAM assays have …

Cd36 Deletion Hampers T-Bet B Cell-Differentiation In R848 Immunized Mice And Hfd Models, Andrea Paredes, G. Sophia Noriega, Carlo Vanz, Emma Collins, Elizabeth A. Leadbetter, Benjamin T. Enslow

Posters - 2025

In states of chronic inflammation, a subset of B cells exquisitely responsive to nucleic acid antigen and expressing the proinflammatory transcription factor T-bet have been found to accumulate1. Depending on the context, these T-bet+ B cells can play both protective and pathogenic roles, from enhancing antiviral defenses to contributing to autoreactive antibody production and exacerbating metabolic disease1,2.

• Recently, our laboratory and others have found that T-bet+ B cells extracted from human or murine tissues exhibit unusually high expression of the class B scavenger receptor and fatty acid translocase CD36.

• As CD36 expression in B cells is generally limited …

The Acute Effects Of High-Intensity Functional Training On Inhibitory Control, Julia Daniel, Amaryllis Rubalcaba, Brianna Valadez

Posters - 2025

High-Intensity Functional Training (HIFT), such as CrossFit®, integrates high-intensity, multi-joint movements and has gained attention for its potential to enhance both physical and cognitive performance. While acute resistance exercise (RE) is known to influence physiological responses like heart rate variability (HRV) and cognitive functions such as inhibitory control, the specific effects of CrossFit®—a structured HIFT program—on cognitive outcomes remain underexplored, particularly when comparing trained CrossFit participants to untrained or non-CrossFit populations. HIFT’s unique combination of cardiorespiratory and muscular stress may uniquely enhance cognitive processing speed and response stability, especially in individuals with chronic CrossFit® experience. However, it is unclear how …

V.O.T.S. Virus Outbreak Tracking System, Izak O. De La Cruz, Elias Ciudad Leon, Van Nguyen, Amy Torres, Enzo Jaques

Posters - 2025

In a post-pandemic world, the need for real-time, accessible disease tracking has never been more critical. While global COVID-19 heat maps were widely utilized during the pandemic, local virus tracking tools have since diminished, leaving a gap in public health awareness.

V.O.T.S. is an interactive application that visualizes real time disease outbreaks through an interactive heatmap, enabling users to track virus trends by county, severity, and timeframe. The system integrates public health data from trusted sources such as the CDC, empowering individuals and healthcare professionals to make informed decisions. In addition, V.O.T.S. enhances accessibility with multilingual support, symptoms assessment, and …

Investigating The Drug Response Of Pdac Cells To Pan-Kras Inhibitor, Jalyn De La Fuente, Yi Xu, Jun Liu, Angel Dominquez, Ava Sanchez, Pei Wang

Posters - 2025

Pancreatic ductal adenocarcinoma (PDAC) is an exocrine pancreatic cancer. It is one of the most lethal types of cancer and is projected to become the second leading cause of cancer-related deaths by 20401 . One major challenge in treating PDAC is drug resistance and the lack of effective treatments. Oncogenic KRAS mutation and loss of function mutation in tumor suppressor genes including P16, TP53, and SMAD4 are found in most PDAC patients. It is unclear whether the different driver mutations can affect the tumor responses to chemo- and targeted therapy. Gemcitabine, a chemotherapy drug, is a cytotoxic agent that has …

Acute Physiological Responses To An Infrared Sauna Blanket Towards Home Based Passive Heat Therapy, Arlene Chaidez, Mia Gonzales, Amaryllis Rubalcaba, Meghan Walls, Rene Barbier

Posters - 2025

Repeated passive heat exposure can improve cardiovascular health outcomes. A novel infrared sauna blanket may enable home-based heat therapy, but these devices are yet understudied. By closely monitoring blood pressure, heart rate, core body temperature, and perceptual responses, it could be determined how a participant's body reacts to the infrared treatment. We found elevated cardiovascular activity in response to the sauna blanket, similar to that observed during moderate-intensity exercise. Therefore, the infrared sauna blanket may have potential for inducing long-term cardiovascular adaptations and become an accessible and costeffective way of treating/preventing chronic illness.

Student Described Importance Of Nurse Educator Caring Actions In Various Class Settings, Jessica Leiberg

Dissertations (1934 -)

Caring pedagogy is a well-known and proven nurse educator instructional approach resulting in improved student attrition, enhanced attitude towards the students’ nursing program, and a caring approach extending into professional practice. Despite much research and development of nurse educator caring actions, the possible effect of different class settings on the student perception of these nurse educator caring actions is unknown. The purpose of this study aimed to identify how students’ rate and rank order the importance of nurse educator caring actions within the different class settings. A descriptive quantitative design was conducted to explore student perceptions of the importance of …

Role For Astrocytes In Complex Cognition: An Evolutionary, Behavioral And Computational Perspective, Gregory Simandl

Dissertations (1934 -)

The human brain has more computational power than modern supercomputers by utilizing only a few signaling systems, rendering it the most efficient computational device ever created. Evolution, though not prospective, has iteratively constructed neural networks of increasing complexity that have ultimately endowed humans with extraordinary cognitive abilities. Through an evolutionary lens, there is a clear correlation between organismal sophistication and network signaling complexity Astrocytes, a non-neuronal cell that makes up approximately half the cells in the human brain, show dramatic increases in morphological and signaling complexity in higher-order species. This co-evolution is likely not coincidental but rather represents the development …

The Impact Of Electronic Health Record Training: How Students Utilize The Electronic Record To Inform Clinical Judgment, Sarah Marie Calonder

Dissertations (1934 -)

Nurses practice within a complex healthcare environment and must make well-informed judgments about their patients to provide safe, quality care. The electronic health record (EHR) is a piece of healthcare and informatics technology which houses important patient information that nurses utilize frequently while making clinical judgments surrounding patient care. The importance of entry-level nurse competency with the EHR and similar healthcare and informatics tools has been outlined by the American Association of Colleges of Nursing (AACN) Essentials and other nursing organizations concerned with the preparation of future nurses (AACN 2021; QSEN, 2020). Currently, there are limited established best practices for …

Confirming The Validity And Reliability Of The Placement Evaluation Tool To Evaluate Midwifery Practice Placements (Pet-Midwifery), Fiona Bogossian, Dianne Bloxsome, Angela Brown, Robyn Cant, Susan Hunter, Lauren Kearney, Lesley Kuliukas, Carolyn Ross, Simon Cooper

Research outputs 2022 to 2026

Problem: In Australia, program accreditation requirements include that education providers monitor and evaluate teaching and learning environments and provide evidence of outcomes being used to inform program quality improvement. Yet, closing this loop has proven challenging. Background: The Australian National Placement Evaluation Centre (NPEC) functions to measure the quality of placements through student evaluations. One measure the Placement Evaluation Tool (PET) had not been tested in midwifery student cohorts. Aim: To confirm the validity and reliability of the Placement Evaluation Tool (PET) for midwifery. Design: Survey instrument development. Methods: A three-phase, sequential study involving seven Australian universities and students enrolled …

Comparison Between Shoulder Flexed And Extended Positions In Elbow Flexion Resistance Training On Regional Hypertrophy And Maximum Strength: Preacher Versus Bayesian Cable Curls, Parsa Attarieh, João Pedro Nunes, Saeed Khani, Saman Negahdar, Amirali Goli, Hamed Nazarirad, Shahriar Nazarirad, Shima Mojtahedi, Kazunori Nosaka, Rahman Soori

Research outputs 2022 to 2026

In the present study, the effects of resistance training on regional hypertrophy and maximum strength of the elbow flexor muscles were compared between elbow flexion exercises performed with different shoulder joint angles (∼50° of flexion vs. extension) while matched for resistance profiles. In a within-subject design, 15 young men (25.6 ± 2.1 y; 77.3 ± 6.8 kg; 175.1 ± 5.7 cm) underwent a resistance training program twice a week for 10 weeks (3–5 sets, 8–12RM), and their arms were dominant-side balanced, randomly assigned to one of the two conditions according to elbow flexion exercises: unilateral cable curl with shoulder flexed …

How Sexism Affects Women In Healthcare And Medical Training In The United States And The United Kingdom, Emily Kerr

Honors Projects

This in-depth secondary research was performed to review existing literature about how sexism affects women in healthcare and medical training in the United States and the United Kingdom. Despite previous legislation passed to limit sexism and sexual harassment in both countries, sexism and sexual harassment are still relevant today, especially in the medical and healthcare field. In fact, despite a continued increase of women in medicine, 91% of qualified female health professionals have experienced sexism at work and 54% of both male and female health professionals believe that sexism acts as a barrier to career progression (BMA, 2024). Based on …

Resting Energy Expenditure And Metabolic Features In Children With Septo-Optic Dysplasia, David J. Cullingford, Jacqueline A. Curran, Mary B. Abraham, Aris Siafarikas, A. Marie Blackmore, Jenny Downs, Catherine S.Y. Choong

Research outputs 2022 to 2026

Context: Septo-optic dysplasia (SOD) is a major cause of congenital hypopituitarism and is known to be associated with overweight and obesity in up to 44% of children. Given the role of the hypothalamus in hormonal regulation, we sought to assess the association of resting energy expenditure (REE), appetite and physical activity with SOD. Objective: To characterize REE and other metabolic features in patients with SOD and evaluate relationships with elevated body mass index (BMI). Methods: Children with SOD above 5 years of age attending Perth Children's Hospital participated. A CosMED Q-NRG indirect calorimeter was used to calculate mean measure REE …