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Full-Text Articles in Medicine and Health Sciences

Surviving The Stigma: Incorporating Mental Health Literacy To Increase Help-Seeking In California First Responders, Yvonne C. Newson May 2023

Surviving The Stigma: Incorporating Mental Health Literacy To Increase Help-Seeking In California First Responders, Yvonne C. Newson

Master's Projects and Capstones

First responders are at risk of developing mental health problems due to repeated exposure to traumatic incidents, increasing their chance of developing Post Traumatic Stress Disorder, substance abuse, suicidal ideation, and suicide. Unfortunately, first responders do not recognize that they may have a mental illness and are reluctant to seek help. This paper will discuss the prevalence of mental health problems among first responders and the barriers to their help-seeking. These barriers include the stigma around mental illness within the culture, the assessability of professional help, and the lack of mental health literacy regarding their well-being. Further discussion will focus …


Measuring Outcomes Of Occupational Therapy Facilitated In Natural Settings With Young Children, Amie Smith, Deepak Dale, Brinda Saini, Zoe Peters, Amanda Laccone May 2023

Measuring Outcomes Of Occupational Therapy Facilitated In Natural Settings With Young Children, Amie Smith, Deepak Dale, Brinda Saini, Zoe Peters, Amanda Laccone

Occupational Therapy | Graduate Capstone Projects

To date, there is limited evidence to support the effectiveness of Occupational Therapy (OT) services delivered outside in nature. This study explored the benefits of OT intervention in Natural Settings (NS) for children by examining development in the areas of self-regulation, social skills, sensory processing, confidence, and motor skills. A quantitative, quasi-experimental pre-test/post-test design was used in this study. Researchers partnered with a local outpatient OT clinic that offers an 8-week outdoor program. Seven children and their parents were recruited and participated in the study. A modified version of the COPM and two BOT-2 subtests, along with a novel log …


Support For Social Workers Treating Adolescent Substance Abusers, Monica Delucia, Kethura Solano May 2023

Support For Social Workers Treating Adolescent Substance Abusers, Monica Delucia, Kethura Solano

Electronic Theses, Projects, and Dissertations

This study examines the barriers social workers experience when working with adolescent substance users. Research has not fully explored if intervention techniques are effective or suggest other approaches that may support substance use disorder professionals including supervisor support, training, and intervention. The purpose of this study was to evaluate if social workers who provide interventions to adolescent substance users have the adequate resources to be successful in their field. The literature review provides a better understanding of the common themes social workers experience when working with adolescent substance users.

This study used a qualitative design and interviewed 8 professional social …


Neurosteroids As Stress Modulators And Neurotherapeutics: Lessons From The Retina, Yukitoshi Izumi, Makoto Ishikawa, Toru Nakazawa, Hiroshi Kunikata, Kota Sato, Douglas F. Covey, Charles F. Zorumski May 2023

Neurosteroids As Stress Modulators And Neurotherapeutics: Lessons From The Retina, Yukitoshi Izumi, Makoto Ishikawa, Toru Nakazawa, Hiroshi Kunikata, Kota Sato, Douglas F. Covey, Charles F. Zorumski

2020-Current year OA Pubs

Neurosteroids are rapidly emerging as important new therapies in neuropsychiatry, with one such agent, brexanolone, already approved for treatment of postpartum depression, and others on the horizon. These steroids have unique properties, including neuroprotective effects that could benefit a wide range of brain illnesses including depression, anxiety, epilepsy, and neurodegeneration. Over the past 25 years, our group has developed ex vivo rodent models to examine factors contributing to several forms of neurodegeneration in the retina. In the course of this work, we have developed a model of acute closed angle glaucoma that involves incubation of ex vivo retinas under hyperbaric …


Standardized Handoffs For Anesthesia Students, Shawn Barkalow, Noah Prebish Apr 2023

Standardized Handoffs For Anesthesia Students, Shawn Barkalow, Noah Prebish

Doctor of Nursing Practice Scholarly Projects

Communication between healthcare providers is an essential aspect of caring for patients. Effective communication is vital during the patient handoff process. The patient handoff process involves exchanging patient’s medical information between a provider currently caring for the patient and the provider assuming care of the patient. If the information exchanged during the handoff process is inaccurate or essential information is omitted, that could potentially lead to harmful consequences for the patient. Currently, no standardized handoff tool exists for student registered nurse anesthesia students (SRNAs) in clinical practicum at the local level one trauma center. The lack of a standardized handoff …


Breastfeeding After Maternal Anesthesia: A Guideline Development, Megan Berens Apr 2023

Breastfeeding After Maternal Anesthesia: A Guideline Development, Megan Berens

Doctor of Nursing Practice Scholarly Projects

Postoperative breastfeeding recommendations for lactating mothers by anesthesia providers are inconsistent and often inaccurate. Inappropriate recommendations have led to withholding of breastmilk to the infant, unnecessary disposal of breastmilk, surgical delay, exposure of an infant to high levels of drugs in breastmilk, and early cessation of breastfeeding. The purpose of the scholarly project was to develop a set of evidenced-based practice guideline recommendations and a proposed implementation plan for anesthesia providers to use in support of breastfeeding mothers who recover from surgery. Many studies in the literature indicate that there are inconsistencies in postoperative breastfeeding recommendations by anesthesia providers. When …


Creating A Culturally Adaptable Comprehensive Sexuality Education Teacher's Manual, Stephanie Carteciano Apr 2023

Creating A Culturally Adaptable Comprehensive Sexuality Education Teacher's Manual, Stephanie Carteciano

Student Works

Purpose: The purpose of this project was to create a culturally adaptable comprehensive sexual education teacher’s manual by (a) standardizing content using The United Nations Educational, Scientific and Cultural Organization’s (UNESCO) 2018 International Technical Guidance on Sexuality Education (CSE), (b) providing evidence-based CSE pedagogy in the form of classroom activities, and (c) including adaptable teaching methods to fit diverse cultural contexts.

Development: The manual lessons were derived from UNESCO’s 2018 International Technical Guidance on Sexuality Education, and the pedagogy followed Anderson and Krathwohl’s revision of Bloom’s Taxonomy. Health information was obtained from various medical and university resources. We surveyed eight …


Pharmacokinetics Of Single Feeding Of Cannabidiol In Cattle: A Pilot Study, Haley Cornette Apr 2023

Pharmacokinetics Of Single Feeding Of Cannabidiol In Cattle: A Pilot Study, Haley Cornette

Honors College Theses

Cannabidiol (CBD) is a substance that has been used in complementary medicine for many years. However, modern medicine has little knowledge of how this substance is utilized and metabolized in ruminant animals. Regulations on quality assurance and use in animals are lacking, and CBD supplementation in livestock is not approved. If CBD supplements can be shown to be safe and effective, detection in the animal will be important for determining regulation of use. A withdrawal period can then be established to allow time for deterioration of product to safe levels before livestock products enter human markets. This study sought to …


Adult Post-Cardiac Surgery Deep Sternal Wound Infections, Samantha Porcher, Cole Gatzke Apr 2023

Adult Post-Cardiac Surgery Deep Sternal Wound Infections, Samantha Porcher, Cole Gatzke

Nursing DNP Projects

ABSTRACT

Purpose and rationale: Deep Sternal Wound Infections (DSWI) are associated with morbidity rates and mortality rates as high as 10% -15% as well as significantly increased hospital costs. The purpose of this project is to decrease current rates of DSWIs in adults undergoing cardiac surgery at a large medical institution.

Synthesis of evidence: The literature shows a strong relationship between elevated HbA1C and DSWI. All articles reviewed for this proposal which implement a sternal vest intervention support its use to prevent DSWI.

Practice change and implementation strategies: The strategy used to implement these evidence-based practice interventions includes …


Charge-Voltage Curves Of Shaker Potassium Channel Are Not Hysteretic At Steady State, John Cowgill, Baron Chanda Mar 2023

Charge-Voltage Curves Of Shaker Potassium Channel Are Not Hysteretic At Steady State, John Cowgill, Baron Chanda

2020-Current year OA Pubs

Charge-voltage curves of many voltage-gated ion channels exhibit hysteresis but such curves are also a direct measure of free energy of channel gating and, hence, should be path-independent. Here, we identify conditions to measure steady-state charge-voltage curves and show that these are curves are not hysteretic. Charged residues in transmembrane segments of voltage-gated ion channels (VGICs) sense and respond to changes in the electric field. The movement of these gating charges underpins voltage-dependent activation and is also a direct metric of the net free-energy of channel activation. However, for most voltage-gated ion channels, the charge-voltage (Q-V) curves appear to be …


Increasing Student Engagement: Case-Based Teaching And Learning, Necole Leland, Lisa Nicholas Feb 2023

Increasing Student Engagement: Case-Based Teaching And Learning, Necole Leland, Lisa Nicholas

UNLV Best Teaching Practices Expo

Case-based learning (CBL) is an active learning approach using hypothetical or real life problems that help learners develop clinical judgment and problem-solving skills (Bastable, 2023). CBL can be used in multiple settings, including the classroom, the clinical environment, and simulation. CBL can be used in most disciplines to bring real life scenarios to life for learners. Learners identify the problem in the case, develop multiple approaches to solving problems, discuss different viewpoints or assumptions, propose alternate decisions, and weigh consequences (Young & Paterson, 2007). CBL helps make connections that transfer theoretical knowledge to practical application (Billings & Halstead, 2020). CBL …


Session 12: Active Learning To Minimize The Possible Risk From Future Epidemics, Kc Santosh Feb 2023

Session 12: Active Learning To Minimize The Possible Risk From Future Epidemics, Kc Santosh

SDSU Data Science Symposium

In medical imaging informatics, for any future epidemics (e.g., Covid-19), deep learning (DL) models are of no use as they require a large dataset as they take months and even years to collect enough data (with annotations). In such a context, active learning (or human/expert-in-the-loop) is the must, where a machine can learn from the first day with minimum possible labeled data. In unsupervised learning, we propose to build pre-trained DL models that iteratively learn independently over time, where human/expert intervenes only when it makes mistakes and for only a limited data. In our work, deep features are used to …


2d Respiratory Sound Analysis To Detect Lung Abnormalities, Rafia Sharmin Alice, Kc Santosh Feb 2023

2d Respiratory Sound Analysis To Detect Lung Abnormalities, Rafia Sharmin Alice, Kc Santosh

SDSU Data Science Symposium

Abstract. In this paper, we analyze deep visual features from 2D data representation(s) of the respiratory sound to detect evidence of lung abnormalities. The primary motivation behind this is that visual cues are more important in decision-making than raw data (lung sound). Early detection and prompt treatments are essential for any future possible respiratory disorders, and respiratory sound is proven to be one of the biomarkers. In contrast to state-of-the-art approaches, we aim at understanding/analyzing visual features using our Convolutional Neural Networks (CNN) tailored Deep Learning Models, where we consider all possible 2D data such as Spectrogram, Mel-frequency Cepstral Coefficients …


Ion Channel Regulation Of Gut Immunity, Jing Feng, Zili Xie, Hongzhen Hu Feb 2023

Ion Channel Regulation Of Gut Immunity, Jing Feng, Zili Xie, Hongzhen Hu

2020-Current year OA Pubs

Mounting evidence indicates that gastrointestinal (GI) homeostasis hinges on communications among many cellular networks including the intestinal epithelium, the immune system, and both intrinsic and extrinsic nerves innervating the gut. The GI tract, especially the colon, is the home base for gut microbiome which dynamically regulates immune function. The gut's immune system also provides an effective defense against harmful pathogens entering the GI tract while maintaining immune homeostasis to avoid exaggerated immune reaction to innocuous food and commensal antigens which are important causes of inflammatory disorders such as coeliac disease and inflammatory bowel diseases (IBD). Various ion channels have been …


The Effects Of Covid-19 On Clinical Coordination And The Education Of Physician Assistant Students, Halley Barke Feb 2023

The Effects Of Covid-19 On Clinical Coordination And The Education Of Physician Assistant Students, Halley Barke

SIU Journal of Medical Science Scholarly Works

COVID-19 left a damaged path since its arrival in December 2019. Clinical Coordination in a Physician Assistant (PA) program is an important aspect of PA education. It is important to examine the effects, good or bad, that COVID-19 and other factors have played in the clinical rotation scheduling and placement of PA students in their clinical rotation experiences. To evaluate those effects, it was determined to look at the encounter numbers from the past seven years in the Evalue online system of students in the Southern Illinois University (SIU) PA program as well as survey results obtained from other institutions …


The Integration Of The Scholarship Of Teaching And Learning Into The Discipline Of Communication Sciences And Disorders, Jennifer Friberg, Jerry K. Hoepner, Allison M. Sauerwein, Kerry Mandulak Feb 2023

The Integration Of The Scholarship Of Teaching And Learning Into The Discipline Of Communication Sciences And Disorders, Jennifer Friberg, Jerry K. Hoepner, Allison M. Sauerwein, Kerry Mandulak

Teaching and Learning in Communication Sciences & Disorders

McKinney (2018) has argued that for the scholarship of teaching and learning (SoTL) to advance within a discipline, the integration of SoTL must be closely examined and opportunities for growth in SoTL must be recognized and discussed. To that end, this paper reflects on the degree to which SoTL is integrated into communication sciences and disorders (CSD) by examining a variety of topics: perspectives and theories historically valued by our discipline, existing supports for SoTL at various levels (i.e., individual teacher-scholars, departments, institutions, and the CSD discipline as a whole), the application of SoTL findings in teaching and learning. Four …


The Utility Of Peer-To-Peer Practice For Teaching Speech-Language Pathology Students Transnasal Endoscopy, Laura L. Wolford, George W. Wolford, Charlotte A. Bolch Feb 2023

The Utility Of Peer-To-Peer Practice For Teaching Speech-Language Pathology Students Transnasal Endoscopy, Laura L. Wolford, George W. Wolford, Charlotte A. Bolch

Teaching and Learning in Communication Sciences & Disorders

Introduction: Transnasal flexible endoscopy (TNFE) is necessary for multiple assessments in speech-language pathology (SLP), but it is generally considered an advanced practice technique to be learned during clinical practice. As such, there is no standardized way that it is taught in training programs, leading to a substantial knowledge gap for new graduates. Though peer-to-peer practice has been discussed as an important step in training, it is not clear whether it confers additional benefits above and beyond simulation. This study sought to answer that question in the areas of student confidence, endoscopy speed, and motivation to pursue further TNFE experiences. Methods: …


Partnering With Students To Increase Engagement And Inclusion In An Undergraduate Phonetics & Acoustics Course, Teresa Roberts, Rik Lemoncello Feb 2023

Partnering With Students To Increase Engagement And Inclusion In An Undergraduate Phonetics & Acoustics Course, Teresa Roberts, Rik Lemoncello

Teaching and Learning in Communication Sciences & Disorders

An introductory phonetics course provides foundational content for future clinical practice and may serve as a student’s first experience within the field of Communication Sciences and Disorders. The Students as Partners framework (Cook-Sather et al., 2014) offers a model for valuing student assets and experiences in co-creating learning materials to enhance active learning and deepen understanding. Incorporating positive affective feelings around learning complex material, integrating technology, and building a mutually respectful learning community can foster inclusive practices. In this manuscript, the authors share how redesigning an introductory Phonetics and Acoustics course at a large, urban, commuter, public university led to …


Student Perspectives On Learning Language Sample Analysis Using Lena, Michelle Flippin Feb 2023

Student Perspectives On Learning Language Sample Analysis Using Lena, Michelle Flippin

Teaching and Learning in Communication Sciences & Disorders

Language sample analysis (LSA) is valuable clinical tool and an important component of comprehensive language assessment. However, LSA is underutilized in real-world practice. SLPs have identified time constraints, insufficient training, and lack of confidence in LSA skills as barriers to regular LSA implementation. Communication science and disorders (CSD) programs have opportunities to provide LSA instruction to address these barriers and prepare students to reliably, feasibly, and confidently use LSA in clinical practice. This pilot study examined CSD students’ perspectives on LSA instruction using the Language ENvironment Analysis System (LENA). Undergraduate students (n = 38) completed a series of two …


Speech Pathology Student Perspectives On Virtual Reality To Learn A Clinical Skill, Bridget Kelly, Joanne Walters, Rachael Unicomb Feb 2023

Speech Pathology Student Perspectives On Virtual Reality To Learn A Clinical Skill, Bridget Kelly, Joanne Walters, Rachael Unicomb

Teaching and Learning in Communication Sciences & Disorders

Evidence supports the use of simulation in educating speech pathology (SP) students, however most of the research has centered on low fidelity techniques as opposed to high fidelity and immersive technologies like virtual reality (VR). Whilst there has been research on the use of VR to teach clinical skills to students in other health disciplines (e.g., dentistry, nursing), use of VR in SP has focused mainly on its use in client intervention. There is an opportunity to use VR to teach clinical skills to SP students, particularly in response to barriers to clinical placement opportunities like the COVID 19 pandemic. …


Teaching End-Of-Life Care In Speech-Language Pathology: A Tutorial, Amanda Stead, Sara Haynie, Monica Vinson Feb 2023

Teaching End-Of-Life Care In Speech-Language Pathology: A Tutorial, Amanda Stead, Sara Haynie, Monica Vinson

Teaching and Learning in Communication Sciences & Disorders

Speech-language pathologists often lack preparation for working with patients near the end of life (EoL). Few academic training programs offer dedicated or sufficient content in the area of end-of-life care (EoLC). Furthermore, traditional knowledge-focused outcomes are not the most effective pedagogical strategy in teaching EoL and palliative care to students. Instead, a focus on self-awareness and personal beliefs in relation to death and dying have been shown to have a positive effect on attitudes toward EoLC. The purposes of this paper are three-fold: First, to explore what is known about the teaching and training of EoL in the discipline of …


Examining The Item-Level Psychometric Properties Of The Self-Efficacy Questionnaire (Seq) For Students In Communication Sciences And Disorders, Sabiha Parveen, Neila Donovan, Gina Morris, Kristi Dickey Feb 2023

Examining The Item-Level Psychometric Properties Of The Self-Efficacy Questionnaire (Seq) For Students In Communication Sciences And Disorders, Sabiha Parveen, Neila Donovan, Gina Morris, Kristi Dickey

Teaching and Learning in Communication Sciences & Disorders

The purpose of this study was to examine the psychometric properties of the Self-Efficacy Questionnaire (SEQ), a self-reported questionnaire using Rasch analysis, a one-parameter logistic probability model based on scientific measurement principles. Rasch analysis was completed using the rating scale model. The various analyses allow researchers to examine the item-level psychometric properties of the SEQ, which result in measures that provide evidence for validity, reliability, and sensitivity of the instrument. Rasch analysis demonstrated that the latent trait established by the SEQ, Perceived Self-efficacy (called self-efficacy from here on), was a unidimensional construct that could be measured on a linear scale. …


Use Of A Living Document To Facilitate Critical Engagement With Social Justice For Undergraduate Audiology And Speech-Languages Pathology Students, Kristen Secora, David H Smith Feb 2023

Use Of A Living Document To Facilitate Critical Engagement With Social Justice For Undergraduate Audiology And Speech-Languages Pathology Students, Kristen Secora, David H Smith

Teaching and Learning in Communication Sciences & Disorders

Although pedagogy focused on social justice, power, and privilege have been included in teacher preparatory programs for a number of years, such topics are much newer and relatively unexplored within the context of Communication Sciences and Disorders (CSD) preprofessional programs. This reflection provides information on use of a living document assignment to encourage undergraduate CSD students to grapple with these difficult topics (e.g., privilege, oppression, social justice, allyship) early in their professional careers resulting in benefits for the students, their future clients, and the field of CSD.


Impact Of The Covid-19 Pandemic On Undergraduate Students Studying Anatomy And Physiology Of Speech And Hearing: A Pilot Investigation, Katelyn J. Kotlarek, Kerry Callahan Mandulak Feb 2023

Impact Of The Covid-19 Pandemic On Undergraduate Students Studying Anatomy And Physiology Of Speech And Hearing: A Pilot Investigation, Katelyn J. Kotlarek, Kerry Callahan Mandulak

Teaching and Learning in Communication Sciences & Disorders

The purpose of this pilot study was to define what changes were experienced in the Fall 2020 semester by students in an undergraduate anatomy and physiology of speech and hearing course and highlight any differences in the experience of first-generation college students (FGCS). An online survey was administered to a single class of undergraduate students. Results indicated that students experienced a variety of challenges related to the pandemic and virtual learning. Differences in the experiences of FGCS compared to traditional students included increased hours worked and feelings of being overwhelmed and spending less time on course content each week. Future …


Coronary Flow And Unloading In Acute Myocardial Infarction Shock, Kiyo Ishikawa Feb 2023

Coronary Flow And Unloading In Acute Myocardial Infarction Shock, Kiyo Ishikawa

Journal of Shock and Hemodynamics

In patients with cardiogenic shock that undergo successful coronary intervention, there are still factors complicating myocardial recovery. There is room for improvement in coronary flow using mechanical circulatory devices, specifically by left ventricular unloading. This idea was further explored in a research study using pigs. Results showed that subjects with acute myocardial infarction who have reduced cardiac contractility and/or high diastolic pressure would benefit from support strategies targeting left ventricular unloading.


A Fair Incentive Scheme For Community Health Workers, Avinandan Bose, Tracey Li, Arunesh Sinha, Tien Mai Feb 2023

A Fair Incentive Scheme For Community Health Workers, Avinandan Bose, Tracey Li, Arunesh Sinha, Tien Mai

Research Collection School Of Computing and Information Systems

Community health workers (CHWs) play a crucial role in the last mile delivery of essential health services to under-served populations in low-income countries. Many non-governmental organizations (NGOs) provide training and support to enable CHWs to deliver health services to their communities, with no charge to the recipients of the services. This includes monetary compensation for the work that CHWs perform, which is broken down into a series of well-defined tasks. In this work, we partner with a NGO D-Tree International to design a fair monetary compensation scheme for tasks performed by CHWs in the semi-autonomous region of Zanzibar in Tanzania, …


One And A Half-Stage Revision With Prosthetic Articulating Spacer For Definitive Management Of Knee Periprosthetic Joint Infection., Ahmed Siddiqi, Yusuf Mahmoud, Salvador A. Forte, Thomas A Novack, James Nace Feb 2023

One And A Half-Stage Revision With Prosthetic Articulating Spacer For Definitive Management Of Knee Periprosthetic Joint Infection., Ahmed Siddiqi, Yusuf Mahmoud, Salvador A. Forte, Thomas A Novack, James Nace

Orthopedic Surgery Resident Research

This paper is a comprehensive review that describes indications, contraindications, clinical outcomes, and pearls and pitfalls of 1.5-stage revision total knee arthroplasty (TKA) utilizing a primary TKA femoral component, all-polyethylene tibial component, and hand-crafted antibiotic cement for the management of chronic periprosthetic joint infection. The 1.5-stage exchange TKA details placement of an articulating spacer for an indefinite period, prolonging revision until reinfection, deterioration of functional status, or construct failure. A 1.5-stage revision TKA technique is a viable option for treatment of chronic periprosthetic knee infections. The inherent advantages of decreased health-care costs, decreased morbidity and mortality, and improved emotional ease …


Second Generation Phenyloxadiazolyl Methyl Sulfones For Thiol-Specific Bioconjugations, Guillaume Dewaele-Le Roi Feb 2023

Second Generation Phenyloxadiazolyl Methyl Sulfones For Thiol-Specific Bioconjugations, Guillaume Dewaele-Le Roi

Dissertations, Theses, and Capstone Projects

The role of antibody-based molecular agents for diagnosis and therapy of cancer has expanded significantly over the past decades. However, most of these constructs are synthesized using traditional bioconjugation methods based on the random ligations between the molecular cargo and lysine residues within the protein. These non-specific approaches can create poorly defined conjugates with suboptimal immunoreactivity and in vivo performance while Site-specific approaches to antibody bioconjugation based on ligations between maleimides and free cysteine residues have long stood as attractive alternatives. Yet the inherent instability of the thiol-maleimide linkage has fueled the search for new, more stable thiol-reactive prosthetic groups. …


Using Exterior Housing Conditions To Predict Elevated Pediatric Blood Lead Levels., Neal J Wilson, Elizabeth Friedman, Kevin Kennedy, Panayiotis T. Manolakos, Lori Reierson, Amy Roberts, Steve Simon Feb 2023

Using Exterior Housing Conditions To Predict Elevated Pediatric Blood Lead Levels., Neal J Wilson, Elizabeth Friedman, Kevin Kennedy, Panayiotis T. Manolakos, Lori Reierson, Amy Roberts, Steve Simon

Manuscripts, Articles, Book Chapters and Other Papers

Housing-based lead paint dust is the most common source of lead exposure for US-born children. Although year of housing construction is a critical indicator of the lead hazard to US children, not all housing of the same age poses the same risk to children. Additional information about housing condition is required to differentiate the housing-based lead risk at the parcel level. This study aimed to identify and assess a method for gathering and using observations of exterior housing conditions to identify active housing-based lead hazards at the parcel level. We used a dataset of pediatric blood lead observations (sample years …


Motor Cortical Excitability And Pre-Supplementary Motor Area Neurochemistry In Healthy Adults With Substantia Nigra Hyperechogenicity, Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina Von Thaler, Clarence Chiang, Kay L. Double Feb 2023

Motor Cortical Excitability And Pre-Supplementary Motor Area Neurochemistry In Healthy Adults With Substantia Nigra Hyperechogenicity, Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina Von Thaler, Clarence Chiang, Kay L. Double

Research outputs 2022 to 2026

Substantia nigra (SN) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for Parkinson's disease. We hypothesized that SN hyperechogenicity in healthy adults aged 50 – 70 years is associated with reduced short-interval intracortical inhibition in primary motor cortex, and that the reduced intracortical inhibition is associated with neurochemical markers of activity in the pre-supplementary motor area (pre-SMA). Short-interval intracortical inhibition and intracortical facilitation in primary motor cortex was assessed with paired-pulse transcranial magnetic stimulation in 23 healthy adults with normal (n = 14; 61 ± 7 yrs) or abnormally enlarged (hyperechogenic; n = 9; 60 ± 6 yrs) area …