Medicine and Health Sciences Commons^™

Efficacy And Safety Of Concomitant Surgical Ablation During Mitral Valve Replacement: A Systematic Review, Omar Hamodat, Saif Almuzainy, Rand Yahya, Razan Alzaatreh, Samiullah Haroon, Salam Koniali

Journal of the Saudi Heart Association

Objectives: Atrial fibrillation (AF) is a common comorbidity in patients undergoing mitral valve surgery (MVS), significantly increasing the risk of thromboembolism, heart failure, and mortality. Surgical ablation has recently been given a Class IA recommendation for concomitant MVS, reinforcing its role in restoring sinus rhythm and improving outcomes in this population. However, concerns about procedural complexity, extended operative time, and postoperative risks have limited its widespread adoption. This systematic review aims to synthesize evidence from recent randomized controlled trials to evaluate the safety and efficacy of surgical ablation for AF in patients undergoing MVS, addressing critical gaps in current clinical …

The Effects Of Estradiol And Genistein On Cerebellar Neuroprotection In Zebra Finches, Grace Thompson, Tony Irovic, Lainy B. Day

Neuroscience Research Showcase

Poster presented at Annual Neuroscience Showcase University of Mississippi related to neuroprotection of genistein and estradiol post-brain lesion.

Creating Educational Curriculum And Fostering Health Promotion For Individuals With Down Syndrome At Gigi’S Playhouse, Allie Hutchinson

OTD Capstone Projects

This doctoral capstone project was completed through partnership with GiGi’s Playhouse Nashville. GiGi’s Playhouse is an organization with over 61+ locations across the United States and Mexico with the purpose of offering free, therapeutic and educational programs for individuals with Down Syndrome. The goal of this project was to create appropriate, educational curriculum for participants in GiGi Nashville’s adult education programs focused on self-confidence, skill knowledge, personal wellness, quality of life and a variety of other topics. A secondary focus of this project was to foster health promotion for individuals with Down syndrome through an emphasis on functional fitness. A …

Introduction To Neuropathy: A Foundational Guide To Understanding Neuropathy, Emilie-Grace King

OTD Capstone Projects

This project centers on the development of a deliverable titled Introduction to Neuropathy: A Foundational Guide to Understanding Neuropathy at Gilda’s Club Middle Tennessee, a nonprofit organization that provides support to individuals impacted by cancer. The initiative aimed to increase awareness and understanding of peripheral neuropathy—a common and often debilitating side effect of treatments related to cancer and other diagnosis —among club members, including patients, survivors, and caregivers. Through collaboration with clinical professionals, Gilda’s Club staff, and members of Gilda’s Club, educational materials were curated and presented in an accessible format tailored to the needs of a diverse audience. …

Evidence-Based Practice Consideration For Perioperative Use Of Mepivacaine In Total Knee Arthroplasty, Courtney E. Haley

Doctor of Nursing Practice Scholarly Projects

Total knee arthroplasty (TKA) is becoming increasingly prevalent, with projections of a significant rise in cases by 2050. Optimal perioperative management is essential for enhancing postoperative recovery, minimizing complications, and supporting early discharge. Spinal anesthesia, particularly with long-acting agents like bupivacaine, is commonly used; however, it may lead to prolonged motor blockade and postoperative urinary retention (POUR), impacting recovery. Recent research suggests that mepivacaine, an intermediate-acting spinal anesthetic, may offer improved recovery outcomes for TKA patients compared to bupivacaine. This evidence-based practice project aims to evaluate the effectiveness of mepivacaine in reducing neurologic recovery time, POUR, and length of stay …

A Narrative Review Of Military Reverse Triage., Daniel J Hurst

Rowan-Virtua School of Osteopathic Medicine Departmental Research

INTRODUCTION: Military reverse triage has been described at several points in the literature. However, an extensive review of the concept and any gaps that may exist has not been conducted. This narrative review seeks to understand how reverse triage is used in the military literature and how it might be implemented in practice, as well as the documented historical applications of reverse triage.

MATERIALS AND METHODS: Four databases were searched manually for English-language articles: PubMed, SCOPUS, JSTOR, and Worldwide Political Science Abstracts. In addition, a manual search of references, U.S. DoD, and NATO doctrine, as well as other published works …

Bridging The Gap: Educating Occupational Therapy Students On Services For Medically Complex Children In Prescribed Pediatric Extended Care Centers And Similar Settings, Karleigh Villneuve, Zeida Gutierrez

Spring 2025 OTD Capstone Symposium

The purpose of this project was to educate entry-level OT students on healthcare and OT services for CMC in PPEC centers and similar facilities through an educational seminar and resources. Educating students about healthcare and OT services for CMC in PPEC centers and similar facilities will hopefully increase interest in pursuing a role in this emerging practice area and increase advocacy efforts for this vulnerable population.

Relationship Between Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Inflammatory Biomarkers, And Hospital Length Of Stay Among Covid-19 Patients., Alice Aghamie Osuji

Walden Dissertations and Doctoral Studies

COVID-19 has put immense pressure on healthcare facilities, especially in managing patients with comorbidity. This study addressed the association between two important coinfections, congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD), and their effect on hospital length of stay (LOS) among COVID-19 patients. The study also explored the predictive role of the inflammatory biomarker C-reactive protein (CRP) in prolonged hospitalization, also considering the influence of age and race. This study applied the Biopsychosocial Model and Chronic Care Model (CCM) to examine health outcomes and resource use. A retrospective cohort research design was used to examine medical records of …

Management Of Sensory Processing Differences To Support Children’S Participation In Church, Sarah Allen

OTD Capstone Projects

This doctoral capstone project was completed in partnership with the First Presbyterian Church of Nashville (FPCN), with the shared objective of fostering a more inclusive and sensory-friendly environment within its Children’s Ministry. In alignment with FPCN’s mission to nurture young disciples through holistic, age-appropriate faith formation, this project addressed the growing need to accommodate children’s diverse sensory needs. Key outcomes included improved staff confidence as measured through pre- and post-training surveys, the creation of a resource binder on sensory processing, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD), and concrete changes to curriculum structure and classroom environments to better support …

Combating The Impact Of Adverse Childhood Experiences On Self-Esteem And Emotion Regulation: An Art-Based Intervention Program, Kaileigh Kirk, Cynthia Haynes

Spring 2025 OTD Capstone Symposium

This poster presents an art-based intervention program developed and designed to positively impact self-esteem and emotion regulation in children with Adverse Childhood Experiences (ACEs) through evidence-based intervention activities and group discussions. This program was created with the hopes of expanding occupational therapy's knowledge and utilization of potential interventions for children with ACEs.

Effectiveness Of A Mindfulness Program On Traumatic Upper Extremity Injuries, Chloe M. Greer, Zeida Gutierrez, Julie Ward

Spring 2025 OTD Capstone Symposium

The general overview of this research study is to develop and assess the effectiveness of a mindfulness program for supporting the psychosocial symptoms that are associated with post traumatic UE injuries. Mindfulness as an intervention will be used to support possible negative psychosocial implications the patient is experiencing post traumatic injury.

Researching Effective Interventions Within Occupational Therapy For Individuals With Complex Regional Pain Syndrome, Brooklyn Devenny, Zeida Gutierrez, Jen Neuenfeldt

Spring 2025 OTD Capstone Symposium

This research project assessed client and clinician perceptions on the effectiveness of treatment interventions for CRPS. The purpose of this research was to assess the effectiveness of interventions for CRPS as perceived by clinicians and clients to evaluate the impact on client function and overall satisfaction coping with CRPS.

Advocacy For On-Campus Occupational Therapy In College Athletics, Doyle C. Taylor, Keisa Boykin

Spring 2025 OTD Capstone Symposium

This project focuses on a growing issue in college sports: the lack of accessible, specialized rehabilitation for student-athletes. Many universities rely on off-campus providers for occupational therapy, which often leads to delays in treatment, missed appointments, and inconsistent care. To address this gap, the project advocates for the integration of occupational therapists directly into athletic departments. By developing and delivering educational workshops, distributing advocacy materials, and engaging with key stakeholders, the project highlights how on-campus OT services can streamline care, improve recovery outcomes, and support both the physical and mental well-being of student-athletes. The goal is to bring awareness to …

The Impact Of Perfusion Techniques On Inflammatory Response During Cardiopulmonary Bypass; A Scoping Review, Rodolfo Alfaro

Student Works

Background: Cardiopulmonary bypass (CPB) is an essential part of cardiac surgery, but it leads to SIRS (systemic inflammatory response syndrome) which in turn increases postoperative complications. There are many proposed approaches to reduce inflammation, but there is no clear best practice on the approach to use. This scoping review aims to explore the literature and classify the studies that investigate the effects of various CPB perfusion techniques on inflammatory responses to determine the possible best practices and the gaps that exist in the literature.

Methods: The present scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews …

Impact Of Cde Referral On A1c Control In Adult Type 2 Dm Patients., Alivia Watts Bsn, Rn, Yesica Sanchez Bsn, Rn, Morgan Hilliard Bsn, Rn, Laura Reed Dnp, Fnp-Bc

Doctor of Nursing Practice Projects

Type II Diabetes Mellitus is a chronic health condition impacting many adults in Tennessee. Certified Diabetic Educators (CDEs) are specifically trained in educating and addressing the health care needs of patients with diagnoses of Type I or Type II Diabetes. Research has shown that education conducted by CDEs leads to improved outcomes and self- care in those with diabetes (Bowen, et al., 2016, King et al., 2019). Not only are CDEs cost effective services leading to a decrease in healthcare costs, but they also aid in the improvement of hemoglobin A1C (Hgb A1C) levels and decrease complications associated with Type …

Blind Early Services Tn: An Inclusive Summer Camp, Caroline Mcdermott

OTD Capstone Projects

This doctoral capstone project was completed in partnership with Blind Early Services Tennessee (BEST), a non-profit organization with the focus on early intervention-based services for children with visual impairments. Currently, BEST serves over 200 families across the state of Tennessee with the following providers; teachers of the visually impaired (TVI), orientation & mobility specialists (O&M), and occupational therapists (OT). The focus of this project was to create BEST’s second annual summer camp, free of charge to participants, with activities specifically catered toward and adapted for children with low vision. Deliverables included a schedule of sensory, motor, and literacy activities, a …

A Guide To Home Modifications Through The Ot Lens, Alexis Pitman

OTD Capstone Projects

This doctoral capstone was completed through partnership with Westminster Home Connection. Westminster Home Connection is a non-profit agency serving low income adults 60+ or individuals with a disability by providing home repair and modifications to allow individuals to safely live in their home. The primary focus of this project was to create educational materials and bring an OT perspective to the assessment and modification process. Resources provided included a guidebook for home modifications and fall prevention education. Throughout this project I attended and assisted with home assessments, home modification, ramp builds, and declutter projects.

Investigating The Effects Of Sex And Estrous Cycle On The Incubation Of Cue-Induced Oxycodone Craving, Bhumiben Pradipkumar Patel

Theses and Dissertations

The overprescription and misuse of opioids like oxycodone has played a significant role in the ongoing opioid crisis. While effective painkillers, drugs like oxycodone are also reinforcing and often misused. While sex and ovarian hormones can impact the analgesic effects of these drugs, the impact of these factors on oxycodone reinforcement are not fully understood. This relationship between ovarian hormones and opioid reward is further complicated by the fact that opioid use can disrupt ovarian hormone levels and produce reproductive cycle irregularities. Using a rat model of drug craving and relapse vulnerability, we found that chronic oxycodone exposure produced reproductive …

Association Of Driving With Blood Delta-9-Tetrahydrocannabinol: A Systematic Review, Danial Behzad, Sampson Zhao, Reena Besa, Bruna Brands, Christine M. Wickens, Marilyn A. Huestis, Bernard Le Foll, Patricia Di Ciano

Institute of Emerging Health Professions Faculty Papers

IMPORTANCE: Driving under the influence of cannabis increases the risk of motor vehicle collisions. In some jurisdictions, deterrence rests on the ability to detect delta-9-tetrahydrocannabinol (THC) in blood. Recent evidence suggests that there may be a nuanced relationship of blood THC to driving.

OBJECTIVE: The purpose of this systematic review was to summarize all published papers investigating the presence of a linear relationship between blood THC and driving, primarily measured by simulated driving in the lab.

OUTCOMES: The main outcomes assessed included "weaving"/lateral control (eg, standard deviation of lateral position), speed, car following (following distance; coherence), reaction time, and overall …

Advocating For Pots; A Misdiagnosed And Underserved Population, Abbey E. Zimmers, Zeida Gutierrez

Spring 2025 OTD Capstone Symposium

Postural Orthostatic Tachycardia Syndrome (POTS) is a form of dysautonomia that primarily affects the autonomic nervous system, making daily activities such as standing or concentrating difficult due to symptoms like fatigue, dizziness, and brain fog. It is most common in young women, often triggered by autoimmune diseases, viral infections, or trauma. POTS is under-diagnosed, with healthcare providers often unaware of its full spectrum of symptoms and the role of occupational therapy in managing daily function. Occupational therapy (OT) can significantly improve quality of life by helping patients manage symptoms and regain independence. Raising awareness of POTS and the benefits of …

The Impact Of A Sel-Based School Transition Readiness Program For Fifth Grade Students, Abigail V. Hall, Cynthia Haynes, Trish Chialastri

Spring 2025 OTD Capstone Symposium

This poster presents a study that developed and evaluated a Social-Emotional Learning (SEL) based educational program designed to support fifth-grade students transitioning to middle school. This program targeted five key SEL skills: Self-Awareness, Self-Management, Social-Awareness, Relationship Skills, and Responsible Decision-Making. The study aimed to improve students' occupational performance and self-perceived skill sets while also expanding knowledge on the role of OT with a psychosocial emphasis. The research addresses the gap in knowledge regarding SEL-based interventions for supporting students during critical educational transitions.

Assessing Social Media Experiences Of Young Adults And Its Impact On Mental Functions And Daily Routine Performances, Dominique E. Barron, Lakeisa Boykin

Spring 2025 OTD Capstone Symposium

This capstone project is a qualitative research study investigating the relationship between social media and the wellbeing of users.

Support Group Development For The Mental Health Of Parents Of Children With Complex Diagnoses, Sarah G. Bonner, Lakesia Boykin, Dana Madalon

Spring 2025 OTD Capstone Symposium

This presentation covers support group program development for the mental health of parents of children with complex diagnoses. It outlines the need for emotional support, describes the group activities used to promote coping and resilience, and explains how the program was implemented and evaluated using pre- and post-surveys.

Exploring The Impact Of Ot On Pain Management & Quality Of Life In Individuals Following Lower Limb Amputation, Fernanda D. Massey, Lakeisa Boykin

Spring 2025 OTD Capstone Symposium

This capstone project explores the role of occupational therapy (OT) in managing pain and enhancing quality of life (QoL) for individuals following lower limb amputation (LLA). Despite OT's recognized potential in addressing physical and psychosocial challenges, there is a lack of research specifically examining its impact on pain management outcomes post-amputation. This mixed-methods study involved quantitative surveys and qualitative interviews with 11 participants to assess their experiences with OT services, pain strategies, and QoL. Results highlighted both the benefits and limitations of current OT interventions, emphasizing the need for personalized, client-centered approaches. Themes such as the search for non-pharmacological strategies, …

Ahr Activation At The Air-Blood Barrier Alters Systemic Microrna Release After Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals, Ankit Aryal, Ashlyn C. Harmon, Alexandra Noël, Qingzhao Yu, Kurt J. Varner, Tammy R. Dugas

School of Public Health Faculty Publications

Particulate matter containing environmentally persistent free radicals (EPFRs) is formed when organic pollutants are incompletely burned and adsorb to the surface of particles containing redox-active metals. Our prior studies showed that in mice, EPFR inhalation impaired vascular relaxation in a dose- and endothelium-dependent manner. We also observed that activation of the aryl hydrocarbon receptor (AhR) in the alveolar type-II (AT-II) cells that form the air-blood interface stimulates the release of systemic factors that promote endothelial dysfunction in vessels peripheral to the lung. AhR is a recognized regulator of microRNA (miRNA) biogenesis, and miRNA control diverse signaling pathways. We thus hypothesized …

Large-Scale Multi-Omics Analyses In Hispanic/Latino Populations Identify Genes For Cardiometabolic Traits, Lauren E Petty, Hung-Hsin Chen, Elizabeth G Frankel, Wanying Zhu, Carolina G Downie, Mariaelisa Graff, Phillip Lin, Priya Sharma, Xinruo Zhang, Alyssa C Scartozzi, Rashedeh Roshani, Joshua M Landman, Michael Boehnke, Donald W Bowden, John C Chambers, Anubha Mahajan, Mark I Mccarthy, Maggie C Y Ng, Xueling Sim, Cassandra N Spracklen, Weihua Zhang, Michael Preuss, Erwin P Bottinger, Girish N Nadkarni, Ruth J F Loos, Yii-Der Ida Chen, Jingyi Tan, Eli Ipp, Pauline Genter, Leslie S Emery, Tin Louie, Tamar Sofer, Adrienne M Stilp, Kent D Taylor, Anny H Xiang, Thomas A Buchanan, Kathryn Roll, Chuan Gao, Nicholette D Palmer, Jill M Norris, Lynne E Wagenknecht, Darryl Nousome, Rohit Varma, Roberta Mckean-Cowdin, Xiuqing Guo, Yang Hai, Willa Hsueh, Kevin Sandow, Esteban J Parra, Miguel Cruz, Adan Valladares-Salgado, Niels Wacher-Rodarte, Jerome I Rotter, Mark O Goodarzi, Stephen S Rich, Alain Bertoni, Leslie J Raffel, Jerry L Nadler, Fouad R Kandeel, Ravindranath Duggirala, John Blangero, Donna M Lehman, Ralph A Defronzo, Farook Thameem, Yujie Wang, Sheila Gahagan, Estela Blanco, Raquel Burrows, Alicia Huerta-Chagoya, Jose C Florez, Teresa Tusie-Luna, Clicerio González-Villalpando, Lorena Orozco, Christopher A Haiman, Craig L Hanis, Rebecca Rohde, Eric A Whitsel, Alexander P Reiner, Charles Kooperberg, Yun Li, Qing Duan, Miryoung Lee, Paulina Correa-Burrows, Susan K Fried, Kari E North, Joseph B Mccormick, Susan P Fisher-Hoch, Eric R Gamazon, Andrew P Morris, Josep M Mercader, Heather M Highland, Jennifer E Below

Faculty, Staff and Student Publications

Here, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with …

Whole Genome Sequencing Analysis Of Body Mass Index Identifies Novel African Ancestry-Specific Risk Allele, Xinruo Zhang, Jennifer A Brody, Mariaelisa Graff, Heather M Highland, Nathalie Chami, Hanfei Xu, Zhe Wang, Kendra R Ferrier, Geetha Chittoor, Navya Shilpa Josyula, Mariah Meyer, Shreyash Gupta, Xihao Li, Zilin Li, Matthew A Allison, Diane M Becker, Lawrence F Bielak, Joshua C Bis, Meher Preethi Boorgula, Donald W Bowden, Jai G Broome, Erin J Buth, Christopher S Carlson, Kyong-Mi Chang, Sameer Chavan, Yen-Feng Chiu, Lee-Ming Chuang, Matthew P Conomos, Dawn L Demeo, Mengmeng Du, Ravindranath Duggirala, Celeste Eng, Alison E Fohner, Barry I Freedman, Melanie E Garrett, Xiuqing Guo, Chris Haiman, Benjamin D Heavner, Bertha Hidalgo, James E Hixson, Yuk-Lam Ho, Brian D Hobbs, Donglei Hu, Qin Hui, Chii-Min Hwu, Rebecca D Jackson, Deepti Jain, Rita R Kalyani, Sharon L R Kardia, Tanika N Kelly, Ethan M Lange, Michael Lenoir, Changwei Li, Loic Le Marchand, Merry-Lynn N Mcdonald, Caitlin P Mchugh, Alanna C Morrison, Take Naseri, Jeffrey O'Connell, Christopher J O'Donnell, Nicholette D Palmer, James S Pankow, James A Perry, Ulrike Peters, Michael H Preuss, D C Rao, Elizabeth A Regan, Sefuiva M Reupena, Dan M Roden, Jose Rodriguez-Santana, Colleen M Sitlani, Jennifer A Smith, Hemant K Tiwari, Ramachandran S Vasan, Zeyuan Wang, Daniel E Weeks, Jennifer Wessel, Kerri L Wiggins, Lynne R Wilkens, Peter W F Wilson, Lisa R Yanek, Zachary T Yoneda, Wei Zhao, Sebastian Zöllner, Donna K Arnett, Allison E Ashley-Koch, Kathleen C Barnes, John Blangero, Eric Boerwinkle, Esteban G Burchard, April P Carson, Daniel I Chasman, Yii-Der Ida Chen, Joanne E Curran, Myriam Fornage, Victor R Gordeuk, Jiang He, Susan R Heckbert, Lifang Hou, Marguerite R Irvin, Charles Kooperberg, Ryan L Minster, Braxton D Mitchell, Mehdi Nouraie, Bruce M Psaty, Laura M Raffield, Alexander P Reiner, Stephen S Rich, Jerome I Rotter, M Benjamin Shoemaker, Nicholas L Smith, Kent D Taylor, Marilyn J Telen, Scott T Weiss, Yingze Zhang, Nancy Heard-Costa, Yan V Sun, Xihong Lin, L Adrienne Cupples, Leslie A Lange, Ching-Ti Liu, Ruth J F Loos, Kari E North, Anne E Justice

Faculty, Staff and Student Publications

Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P <  5 × 10

Vasoactive Selection For Pediatric Septic Shock-Where To Begin?, Scott L. Weiss

Department of Pediatrics Faculty Papers

No abstract provided.

Staff Education To Enhance Nurses' Knowledge Of Pressure Injury Prevention, Jacqueline Evette Foster

Walden Dissertations and Doctoral Studies

Summary Hospital-acquired pressure injuries (HAPIs) have a significant negative impact on patient safety and the quality of care. This doctor of nursing practice (DNP) staff education project focused on improving staff nurses’ knowledge in preventing pressure injuries. Recognizing the high incidence of pressure injuries at the project site, this staff education project addressed the critical need to reduce pressure injuries for at-risk patients by providing ongoing education and training to enhance pressure injury management, reduce hospital costs and length of hospitalization, and improve patient care quality. The practice-focused question guiding this staff education project was the following: To what degree …

Total Intestinal Atresia In A Neonate: A Case Report., Cory Nonnemacher, Seth Saylors, Naomi-Liza Denning, Vatche Melkonian, Pablo Aguayo

Manuscripts, Articles, Book Chapters and Other Papers

Intestinal atresias are a common cause of neonatal intestinal obstruction. An extremely rare variant is total intestinal atresia, where no lumen is appreciable from the duodenum through the colon. We describe a case of a 33-week female who was born at an outside hospital and underwent laparotomy for concern for intrauterine perforation and proximal intestinal obstruction. Laparotomy revealed a duodenal perforation and an atresia in the proximal jejunum. Resection of this segment revealed no intestinal lumen distally, and the patient was left in discontinuity and transferred to our tertiary children's hospital. Repeat laparotomy revealed atretic bowel with no lumen through …