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Full-Text Articles in Medicine and Health Sciences

Health Profiles, Risk Factors, And Timing Of First Prenatal Visits Among Colquitt County Residents: An Observational Study To Inform Educational Interventions, Nahimie Louissaint, Danielle Prier, Emeka Ikeakanam, Allison Tresner, Daniel York May 2025

Health Profiles, Risk Factors, And Timing Of First Prenatal Visits Among Colquitt County Residents: An Observational Study To Inform Educational Interventions, Nahimie Louissaint, Danielle Prier, Emeka Ikeakanam, Allison Tresner, Daniel York

Research Day

Introduction: Maternal health disparities remain a critical public health issue in rural Georgia, where limited healthcare access contributes to adverse pregnancy outcomes. Barriers such as provider shortages, transportation difficulties, and socioeconomic constraints delay prenatal care, increasing the risk of complications. This study examines patterns in prenatal care access, common health presentations, and pregnancy-related risk factors to inform targeted educational interventions.

Objective: This study aims to analyze health trends among pregnant women at Sterling Women's Center, focusing on risk factors, symptoms, and timing of initial prenatal visits, with the goal of improving maternal health literacy and care accessibility.

Methods: A retrospective …


The Impact Of Smoking On Ocular Health And Its Link To Lung Cancer, Maryam Ali, Debra Dougher May 2025

The Impact Of Smoking On Ocular Health And Its Link To Lung Cancer, Maryam Ali, Debra Dougher

Research Day

Introduction

Smoking is a well-established risk factor for both ocular diseases and lung cancer, yet its impact on eye health remains underrecognized. Tobacco exposure contributes to oxidative stress, inflammation, and vascular damage, accelerating the progression of cataracts, age-related macular degeneration (AMD), diabetic retinopathy, and glaucoma. Emerging evidence suggests that ocular manifestations in chronic smokers may serve as early indicators of systemic diseases, including lung cancer. This study explores the interconnection between smoking-related ocular pathology and lung cancer, highlighting the potential role of ophthalmic evaluation in early disease detection.

Methods

A systematic literature review was conducted using PubMed, MEDLINE, and Google …


Fall Incidences, Risk Factors, And Health Effects Among Early- And Middle-Aged Elderly People In Rural Areas Of Border Provinces In Southern Thailand, Phnom Sukchan, Tapanan Prateepko, Arinda Ma-A-Lee, Kruawan Hounkong, Penporn Sujiwattanarat, Gornganok Piboonpol May 2025

Fall Incidences, Risk Factors, And Health Effects Among Early- And Middle-Aged Elderly People In Rural Areas Of Border Provinces In Southern Thailand, Phnom Sukchan, Tapanan Prateepko, Arinda Ma-A-Lee, Kruawan Hounkong, Penporn Sujiwattanarat, Gornganok Piboonpol

Journal of Health Research

Background: Elderly individuals with physical and psychological challenges face a high risk of falls. This study aimed to assess the incidence, health effects of, and risk factors for falls among those aged 60-79 years old in Thailand's three southern border provinces.

Methods: A community cross-sectional study was conducted between October 2021 and September 2022. Questionnaires were administered though verbal face-to-face conversations. Descriptive statistics, the Chi-square test, Fisher’s exact test, and logistic regression were used.

Results: A total of 419 elderly participants were recruited, while 374 participated in the study. The incidence of falls was 37.4% with an average of 1.7 …


A Multi-Modal Intervention To Improve Identification, Management, And Prevention Of Recurrent Urinary Tract Infections In The Urgent Care Clinic, Stephanie Krol May 2025

A Multi-Modal Intervention To Improve Identification, Management, And Prevention Of Recurrent Urinary Tract Infections In The Urgent Care Clinic, Stephanie Krol

Evidence-Based Practice Project Reports

Nearly 60% of women will suffer from a urinary tract infection (UTI) in their lifetime, with 20- 40% of them suffering from multiple (Anger et al., 2022). The primary purpose of this evidence-based project was to implement a multi-modal intervention to improve identification of women who suffer from recurrent urinary tract infections (rUTIs) and to assist in the prevention and treatment of future UTIs. Additionally, the project aimed to increase the number of referrals to urology for better management of these patients. This project was implemented at an Urgent Care Clinic (UCC) in northwest Indiana. Eligible participants who presented with …


Comparing Treatment Effectiveness And Patient-Reported Outcome Measures Of Four Treatment Options For Obstructive Sleep Apnea, Robert Diecidue, Dmd, Md, Phd, Mba, Msph, Joseph Harrington, Bs, Erika L. Manning, Phd, Md, Mph, Colin T. Huntley, Md May 2025

Comparing Treatment Effectiveness And Patient-Reported Outcome Measures Of Four Treatment Options For Obstructive Sleep Apnea, Robert Diecidue, Dmd, Md, Phd, Mba, Msph, Joseph Harrington, Bs, Erika L. Manning, Phd, Md, Mph, Colin T. Huntley, Md

Department of Otolaryngology - Head and Neck Surgery Posters

Abstract

- There are four common treatment modalities for obstructive sleep apnea (OSA)

  • CPAP, MAD, UAS, MMA

- Retrospective data was examined to compare efficacies between these treatments for patients treated with one of these four OSA therapies.

  • Primary outcome: Mean disease alleviation (MDA) - calculated value based on improvement of AHI adjusted by compliance.
  • Secondary outcomes: Patient reported outcome measures (PROMs) - ESS, PRAQ, SAQLI

- It was found that the greatest mean disease alleviation was found in patients who underwent MMA. PROMs showed the most significant improvement in daytime sleepiness (ESS) for MMA.


Variance In Heart Rate Variability Between Healthy And Concussed Individuals, Sebastian Herrera Vargas, Joonsuk Choi May 2025

Variance In Heart Rate Variability Between Healthy And Concussed Individuals, Sebastian Herrera Vargas, Joonsuk Choi

Student Scholar Symposium Abstracts and Posters

Heart-Rate Variability (HRV) is the interval between each individual heartbeat, from p-wave to p-wave on an electrocardiogram (ECG). In general, a high HRV indicates that a person has a healthy heart with effective stress management skills. This value means that one branch of the nervous system is not overpowering the other, sympathetic vs parasympathetic–for example. Generally, HRV is related to vagal tone, the ability for your body to activate the parasympathetic system and relax when imminent danger is not present. However, when someone is concussed, the entirety of their autonomic regulation can be affected such that their HRV is altered. …


The Legacy Of William M. Pardridge (1947–2024) On The Science And Fields Concerned With The Physiology Of The Blood-Brain Barrier And The Transport Of Drugs To The Brain, Ruben J. Boado, Ulrich Bickel, Rachita K. Sumbria May 2025

The Legacy Of William M. Pardridge (1947–2024) On The Science And Fields Concerned With The Physiology Of The Blood-Brain Barrier And The Transport Of Drugs To The Brain, Ruben J. Boado, Ulrich Bickel, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

This article highlights the scientific achievements and professional career of William M. Pardridge, who passed away on 18th of June 2024. He was born in 1947 in Bethesda, Maryland, USA. William, known affectionately as Bill, was one of the most influential researchers in the blood-brain barrier (BBB) field. Bill’s research contributions to the field spun over 6 decades at the University of California, Los Angeles, and it was focused on the molecular physiology of the BBB, including the carrier-mediated transport of nutrients and small molecule drugs, the receptor-mediated transport of peptides and molecular Trojan horses, gene therapy of the brain …


How Ideological Background Affects Consumption Of And Attitudes Toward Pornography Amongst Women, Roslyn N. Addy May 2025

How Ideological Background Affects Consumption Of And Attitudes Toward Pornography Amongst Women, Roslyn N. Addy

Student Scholar Symposium Abstracts and Posters

Pornography is a notoriously male dominated field in consumption terms and as such, research regarding women’s consumption of pornography is limited and often contains focus on men’s consumption of pornography. The research conducted by Roslyn Addy and Dr. Desiree Crevecoeur-MacPhail intends to bring women in the pornography sphere as consumers rather than onlookers or subjects of pornography affected by male pornography users. Little is known about women’s actual thoughts, feelings, and use of pornography which limits the market of pornography that targets women and limits real conversations about pornography between women. The researchers have found that ideology does predict pornography …


Towards The Performance Characterization Of A Robotic Multimodal Diagnostic Imaging System, George Papaioannou, Christos Mitrogiannis, Mark Schweitzer, Nikolaos Michailidis, Maria Pappa, Pegah Khosravi, Apostolos Karantanas, Sean Starling, Christian Ruberg May 2025

Towards The Performance Characterization Of A Robotic Multimodal Diagnostic Imaging System, George Papaioannou, Christos Mitrogiannis, Mark Schweitzer, Nikolaos Michailidis, Maria Pappa, Pegah Khosravi, Apostolos Karantanas, Sean Starling, Christian Ruberg

Publications and Research

Characterizing imaging performance requires a multidisciplinary approach that evaluates various interconnected parameters, including dosage optimization and dynamic accuracy. Radiation dose and dynamic accuracy are challenged by patient motion that results in poor image quality. These challenges are more prevalent in the brain/cardiac pediatric patient imaging, as they relate to excess radiation dose that may be associated with various complications. Scanning vulnerable pediatric patients ought to eliminate anesthesia due to critical risks associated in some cases with intracranial hemorrhages, brain strokes, and congenital heart disease. Some pediatric imaging, however, requires prolonged scanning under anesthesia. It can often be a laborious, suboptimal …


The Association Of Resistin With Metabolic Health And Obesity In A Mexican-American Population, Reem Al-Dallal, Keziah Thomas, Minjae Lee, Aysha Chaudhri, Eleanor Davis, Priyanka Vaidya, Miryoung Lee, Joseph B Mccormick, Susan P Fisher-Hoch, Absalon D Gutierrez May 2025

The Association Of Resistin With Metabolic Health And Obesity In A Mexican-American Population, Reem Al-Dallal, Keziah Thomas, Minjae Lee, Aysha Chaudhri, Eleanor Davis, Priyanka Vaidya, Miryoung Lee, Joseph B Mccormick, Susan P Fisher-Hoch, Absalon D Gutierrez

Faculty, Staff and Student Publications

Research on the relationship between resistin levels, metabolic health, and obesity has produced inconsistent findings across different ethnic groups, making it unclear whether lower resistin levels are associated with these conditions in Mexican-Americans. This cross-sectional study investigated the relationship between resistin, metabolic health, and obesity in an adult Mexican-American cohort (n = 1511) using multivariable linear regression analysis. Related adipokines (leptin and adiponectin) were measured simultaneously. Participants were categorized into four groups by metabolic health (healthy/unhealthy) and obesity (obese/non-obese) status. “Metabolically unhealthy” was defined as ≥2 cardiometabolic abnormalities. Obesity was defined as a BMI ≥ 30 kg/m2. We also …


Exploring The Relationship Between Disability And Stress: A Preliminary Study, Katie Mcclyman May 2025

Exploring The Relationship Between Disability And Stress: A Preliminary Study, Katie Mcclyman

Undergraduate University Honors Capstones

Mental health issues can become disabling, and living with a disability in an ableist world can cause mental health struggles. This project explores what aspects of living with a disability generate stress. This project is a survey that gathered data through a two-questionnaire survey of disabled college-aged students. The need for a project like this came from the fact that there is not substantial research from the field of psychology done on disabled people and the relationship between disability and stress. The results of this study found that the more disability impact increases, so does disability related stress. This means …


Sugammadex For Reversal Of Neuromuscular Blocking Agents Versus Neostigmine - Safety Comparison, Amanda K. Butler, Daniel Belu, Bailey Accardo, Courtney Ayana Bullard, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Hget-C, Ebp-C, Dwayne Accardo Dnp, Crna, Faana May 2025

Sugammadex For Reversal Of Neuromuscular Blocking Agents Versus Neostigmine - Safety Comparison, Amanda K. Butler, Daniel Belu, Bailey Accardo, Courtney Ayana Bullard, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Hget-C, Ebp-C, Dwayne Accardo Dnp, Crna, Faana

Doctor of Nursing Practice Projects

Purpose/Background

Sugammadex and neostigmine are two common drugs used to reverse neuromuscular blockade in anesthesia, but they differ in mechanism of action, side effects, and cost.

Sugammadex provides rapid reversal, has fewer side effects, and has a lower risk of bradycardia than neostigmine. This scoping review examines the frequency of bradycardia in adult surgical patients receiving sugammadex versus neostigmine.

Methods

A scoping review was completed of peer-reviewed articles comparing the incidence of bradycardia in adult surgical patients after the administration of sugammadex and neostigmine for neuromuscular blockade reversal. Findings indicate that sugammadex resulted in fewer adverse events, including bradycardia, than …


Theoretical And Experimental Synthesis Of Β-Fluorinated Morphine Derivative For Selective Binding In Inflamed Tissue, Thu Doan, Amelia Bayha, Adel Martinez, Nayiri Alexander May 2025

Theoretical And Experimental Synthesis Of Β-Fluorinated Morphine Derivative For Selective Binding In Inflamed Tissue, Thu Doan, Amelia Bayha, Adel Martinez, Nayiri Alexander

Student Scholar Symposium Abstracts and Posters

Over the past two decades, the United States has experienced a substantial rise in opioid overdoses and related fatalities. Morphine is a frequent prescription for pain management following traumatic procedures and contributes to potential tolerance and dependency with prolonged use. By reconstructing the structure of morphine, adverse side effects may be eliminated. Previous studies have identified several morphine derivatives that, in theory, could result in fewer side effects. This was determined by a decreased pKₐ of the biochemically active amine group to promote the selective binding in peripheral opioid receptors within inflamed tissue (pH=6-6.5). This activation provides analgesia while central …


Activity Of Novel Ceftibuten-Avibactam, Ceftazidime-Avibactam, And Comparators Against A Challenge Set Of Enterobacterales From Outpatient Centers And Nursing Homes Across The United States (2022-2024), Aliaa Fouad, May M. Bobenchik, Robin Chamberland, Andrew E. Clark, Holly K. Huse, Isabella W. Martin, A Brian Mochon, Erik Munson, Maroun M. Sfeir, Monica Srodon, Kimberly A. Taylor Dnp, Rn, Nea-Bc, Cnor, Clssbb, Yungchou Wang, Lars F. Westblade, David P. Nicolau, Tomefa E. Asempa May 2025

Activity Of Novel Ceftibuten-Avibactam, Ceftazidime-Avibactam, And Comparators Against A Challenge Set Of Enterobacterales From Outpatient Centers And Nursing Homes Across The United States (2022-2024), Aliaa Fouad, May M. Bobenchik, Robin Chamberland, Andrew E. Clark, Holly K. Huse, Isabella W. Martin, A Brian Mochon, Erik Munson, Maroun M. Sfeir, Monica Srodon, Kimberly A. Taylor Dnp, Rn, Nea-Bc, Cnor, Clssbb, Yungchou Wang, Lars F. Westblade, David P. Nicolau, Tomefa E. Asempa

Publications

Ceftibuten is being developed in combination with the oral prodrug of avibactam. Outpatient isolates (n = 500) from 11 US states underwent susceptibility testing with manual broth microdilution. Ceftibuten had susceptibility rates of 64% (CLSI) and 23% (EUCAST). Ceftibuten-avibactam achieved 96.4% inhibition at MIC ≤ 1 µg/mL. Susceptibility rates were as follows: cefpodoxime (2.6%), ceftriaxone (1%), ceftazidime-avibactam (99.6%), tebipenem (89%), ertapenem (94.4%), levofloxacin (26.6%), trimethoprim-sulfamethoxazole (40.2%), and fosfomycin (96.8%). Ceftibuten-avibactam demonstrates potent in vitro activity against cephalosporin non-susceptible isolates.


Podcasts In Mental, Physical, Or Combined Health Interventions For Adults: Scoping Review, Elizabeth M. Dascombe, Philip J. Morgan, Ryan J. Drew, Casey P. Regan, Gabrielle Turner-Mcgrievy, Myles D. Young May 2025

Podcasts In Mental, Physical, Or Combined Health Interventions For Adults: Scoping Review, Elizabeth M. Dascombe, Philip J. Morgan, Ryan J. Drew, Casey P. Regan, Gabrielle Turner-Mcgrievy, Myles D. Young

Faculty Publications

Background:

The increasing prevalence of poor mental and physical health in adults is a global health concern. Given the scope of this problem, scalable and effective treatment interventions are needed. While podcasts (online digital audio files) are becoming more popular, the extent of podcast use in mental, physical, or combined health interventions has not been reviewed.

Objective:

This scoping review primarily aims to summarize the available evidence regarding the use of podcasts in health promotion interventions. A series of 5 research questions was designed to systematically review and accurately represent podcast use in current research interventions.

Methods:

We conducted a …


The Seroprevalence And Risk Factors For Spotted Fever Group And Typhus Group Rickettsia Along The Texas-Mexico Border, Frederick M Cramer, Lauren M Leining, Timothy A Erickson, Josephine Tolan, Craig L Hanis, Eric L Brown, Sarah M Gunter May 2025

The Seroprevalence And Risk Factors For Spotted Fever Group And Typhus Group Rickettsia Along The Texas-Mexico Border, Frederick M Cramer, Lauren M Leining, Timothy A Erickson, Josephine Tolan, Craig L Hanis, Eric L Brown, Sarah M Gunter

Faculty, Staff and Students Publications

Rickettsial pathogens are an endemic and emergent source of disease in Texas, with a historically high rate of transmission along the United States-Mexico border. To better understand the prevalence and risk factors for spotted fever group Rickettsia (SFGR) and typhus group Rickettsia (TGR) along the Texas-Mexico border, we conducted a seroprevalence study of adults residing in Starr County, Texas (N = 616). Plasma samples were screened for IgG reactivity to SFGR and TGR using commercially available ELISA. ELISA-positive samples were confirmed using a dual spot IgG indirect immunofluorescent assay. Seropositivity was defined as having a ≥1:128 titer. Analysis was conducted …


Characterising Acute And Chronic Care Needs: Insights From The Global Burden Of Disease Study 2019, A. A. Asadi-Pooya May 2025

Characterising Acute And Chronic Care Needs: Insights From The Global Burden Of Disease Study 2019, A. A. Asadi-Pooya

Department of Neurology Faculty Papers

Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into acute or chronic care categories. Data were analysed by age, sex, and socio-demographic index, presenting total numbers and contributions to burden metrics such as Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLD), and Years of Life Lost (YLL). Approximately 68% of DALYs were attributed to chronic …


Development And Feasibility Of An Immersive Feedback Protocol To Reduce Knee Moments And Pain With Potential Application To People With Knee Osteoarthritis, Evan Shrier, Shawn Farrokhi, P. Pallante, Natalia Sanchez Aldana May 2025

Development And Feasibility Of An Immersive Feedback Protocol To Reduce Knee Moments And Pain With Potential Application To People With Knee Osteoarthritis, Evan Shrier, Shawn Farrokhi, P. Pallante, Natalia Sanchez Aldana

Student Scholar Symposium Abstracts and Posters

Background: Osteoarthritis (OA) is the most common cause of disability in the US, affecting 1 in 5 people. Of that, 45% will experience OA in at least one knee. To alleviate pain and prevent knee OA disease progression, walking modification techniques have been proposed. While studies and meta-analyses exist suggesting reductions knee moments due to these modifications (Bechard 2012, Bowd 2019, Fregly 2012), little conclusive evidence exists quantifying their effectiveness. Objective: This research aims to assess the feasibility of an immersive bio-feedback system that provides real-time information about how to effectivedly perform walking modifications that reduce knee moments …


Nifuroxazide And 4-Hydroxybenzhydrazone Derivatives As New Antiparasitic (Trypanosoma Cruzi And Leishmania Mexicana) And Anti-Mycobacterium Tuberculosis Agents, Timoteo Delgado-Maldonado, Diana V. Navarrete-Carriola, Lenci K. Vazquez-Jimenez, Alma D. Paz-Gonzalez, Baojie Wan, Scott Franzblau, Othman Mueen Mohammed, Lorena Rodríguez-Páez, Charmina Aguirre-Alvarado, Debasish Bandyopadhyay May 2025

Nifuroxazide And 4-Hydroxybenzhydrazone Derivatives As New Antiparasitic (Trypanosoma Cruzi And Leishmania Mexicana) And Anti-Mycobacterium Tuberculosis Agents, Timoteo Delgado-Maldonado, Diana V. Navarrete-Carriola, Lenci K. Vazquez-Jimenez, Alma D. Paz-Gonzalez, Baojie Wan, Scott Franzblau, Othman Mueen Mohammed, Lorena Rodríguez-Páez, Charmina Aguirre-Alvarado, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

Background/Objectives: Nifuroxazide (Nfz) is a drug that has been used as a scaffold for designing antimicrobial and antiparasitic agents. This study aimed to synthesize and evaluate in vitro of Nfz and twenty-five 4-hydroxybenzhydrazone derivatives as potential anti-Trypanosoma cruzi, anti-Leishmania mexicana, and anti-Mycobacterium tuberculosis agents.

Methods: The compounds were synthesized by condensing 4-hydroxybenzhydrazide with appropriate aldehydes in acidic conditions and structurally confirmed by spectroscopic techniques. All compounds were evaluated in vitro against T. cruzi strains (NINOA and A1), L. mexicana (M379 and FCQEPS strains), and M. tuberculosis (H37Rv strain), followed by enzymatic assays against T. cruzi …


Patient Perception Of Nurse Practitioner Care, Nurse Practitioner Scope Of Practice And How That Influences Provider Choice, Naomi Hemp May 2025

Patient Perception Of Nurse Practitioner Care, Nurse Practitioner Scope Of Practice And How That Influences Provider Choice, Naomi Hemp

Doctoral Projects

This project investigates patients' perceptions of nurse practitioner (NP) care versus physician (MD) care, the factors influencing these perceptions, and patients' understanding of NP scope of practice. A cross-sectional design was used, gathering quantitative data through an anonymous one-time survey distributed via Qualtrics, open for three months. Questions were based on The Watson Caritas Patient Score (WCPS) and the Hospital Consumer Assessment of Healthcare Providers and Systems Survey (HCAHPS). Data were analyzed using Intellectus Statistics software™, with descriptive statistics summarizing the findings. A two-tailed paired samples t-test revealed statistically significant differences in favor of patients' perceptions of NP care versus …


Human Pain Neuroscience And The Next Generation Of Pain Therapeutics, Bryan A Copits, Michele Curatolo, Patrick M Dougherty, Robert W Gereau, Wenqin Luo, Maryann Martone, Hakan Olausson, Theodore J Price, William Renthal, Clifford J Woolf, Guoyan Zhao May 2025

Human Pain Neuroscience And The Next Generation Of Pain Therapeutics, Bryan A Copits, Michele Curatolo, Patrick M Dougherty, Robert W Gereau, Wenqin Luo, Maryann Martone, Hakan Olausson, Theodore J Price, William Renthal, Clifford J Woolf, Guoyan Zhao

Faculty, Staff and Student Publications

The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.


Rationally Designed Pentapeptide Analogs Of Aβ19-23 Fragment As Potent Inhibitors Of Aβ42 Aggregation, Sachin B. Baravkar, Yan Lu, Qi Zhao, Hongying Peng, Weilie Zhou, Song Hong May 2025

Rationally Designed Pentapeptide Analogs Of Aβ19-23 Fragment As Potent Inhibitors Of Aβ42 Aggregation, Sachin B. Baravkar, Yan Lu, Qi Zhao, Hongying Peng, Weilie Zhou, Song Hong

School of Medicine Faculty Publications

Amyloid beta (Aβ42 and Aβ40) aggregation, along with neurofibrillary tangles, is one of the major neurotoxic events responsible for the onset of Alzheimer's disease. Many potent peptide-based inhibitors mainly focusing on central hydrophobic core Aβ16-20 (KLVFF) have been reported in recent years. Herein, we report pentapeptides -, based on the β-turn-inducing fragment Aβ19-23 (FFAED). The synthesis of peptides - was carried out using Fmoc/tBu-based solid-phase peptide synthesis technique, and it was found that pentapeptide potently inhibit the aggregation propensity of Aβ42, when incubated with it at 37 °C for 48 h. The aggregation inhibition study was conducted using thioflavin T-based …


A Honduran Prevalence Study On Soil-Transmitted Helminths Highlights Serological Antibodies To Tm-Wap49 As A Diagnostic Marker For Exposure To Human Trichuriasis, Neima Briggs, Leroy Versteeg, Rojelio Mejia, Jeroen Pollet, Maria Jose Villar, Bin Zhan, Graeme Segal, Stephanie Novak, Patricia Lenihan, Paul Musgrave, Viviana Ellis, Carol Florencia Coello, K Jagannadha Sastry, Joe Craft, Peter J Hotez, Maria Elena Bottazzi May 2025

A Honduran Prevalence Study On Soil-Transmitted Helminths Highlights Serological Antibodies To Tm-Wap49 As A Diagnostic Marker For Exposure To Human Trichuriasis, Neima Briggs, Leroy Versteeg, Rojelio Mejia, Jeroen Pollet, Maria Jose Villar, Bin Zhan, Graeme Segal, Stephanie Novak, Patricia Lenihan, Paul Musgrave, Viviana Ellis, Carol Florencia Coello, K Jagannadha Sastry, Joe Craft, Peter J Hotez, Maria Elena Bottazzi

Faculty, Staff and Student Publications

Soil-transmitted helminth (STH) infections rank among the most prevalent communicable diseases of humans, yet detection of these parasites is mostly restricted to identifying active infection through fecal examinations. Currently, there are no commercial diagnostic tools to identify a prior whipworm or hookworm exposure, and the few serological assays for roundworm infection have not been well validated for crossreactivity or infections in humans. Such diagnostic restrictions limit the range of scientific and clinical questions that surround STH exposures and their implicated relationship to chronic diseases, such as autoimmunity, allergy, and cancer. The goal of this investigation was to evaluate the diagnostic …


Estradiol Protects Against Pain-Facilitated Fentanyl Use Via Suppression Of Opioid-Evoked Dopamine Activity In Males, Jessica A Higginbotham, Julian G Abt, Rachel H Teich, Joanna J Dearman, Tania Lintz, Jose A Morón May 2025

Estradiol Protects Against Pain-Facilitated Fentanyl Use Via Suppression Of Opioid-Evoked Dopamine Activity In Males, Jessica A Higginbotham, Julian G Abt, Rachel H Teich, Joanna J Dearman, Tania Lintz, Jose A Morón

2020-Current year OA Pubs

Pain relief is the most frequently reported motivation for opioid misuse, but it remains unclear how pain alters reward pathway function contributing to maladaptive opioid use and whether these neuroadaptations occur in a sex-specific manner. Here, we show that persistent inflammatory pain leads to augmented fentanyl self-administration in male, not female, rats. Wireless in vivo fiber photometry recordings and chemogenetic manipulations indicate that pain-facilitated fentanyl use is mediated by enhanced ventral tegmental area dopamine (VTA


Diagnostic Imaging Of A Large Pancreatic Pseudocyst With Infection Over Time In A Dog, Chanyoung Ryu, Wooseok Jin, Sang-Kwon Lee, Daji Noh, Sooyoung Choi, Kija Lee May 2025

Diagnostic Imaging Of A Large Pancreatic Pseudocyst With Infection Over Time In A Dog, Chanyoung Ryu, Wooseok Jin, Sang-Kwon Lee, Daji Noh, Sooyoung Choi, Kija Lee

The Thai Journal of Veterinary Medicine

A 5-year-old Pompitz presented with anorexia and vomiting. Radiographs showed a half-moon-shaped mass in the left cranial abdomen. A large cyst was identified near the left pancreas on ultrasound. Computed tomography revealed a fluid-attenuating mass with rim enhancement in the pancreas. Laboratory tests identified Staphylococcus warneri in the cystic lesion, and pancreatic pseudocyst with infection was suspected. The fluid accumulation and clinical signs recurred over several months. Pre-operative magnetic resonance imaging showed a hyperintense cystic lesion with a duct-like structure and hyperintense line between the cyst and the gastric wall on T2-weighted images as well as signal change of the …


A Rare Splenic Artery Aneurysm In A 19-Year-Old Female, Bailey N. Belcher, Barkley D. Smith, Andres A. Brito, Ravi J. Shekarappa May 2025

A Rare Splenic Artery Aneurysm In A 19-Year-Old Female, Bailey N. Belcher, Barkley D. Smith, Andres A. Brito, Ravi J. Shekarappa

Research Day

Introduction

Splenic Artery Aneurysm (SAA) is a visceral artery aneurysm affecting less than one percent of the general population. Most individuals affected are women in the 5th to 6th decade of life or those with pre-existing conditions including atherosclerosis, portal hypertension, and connective tissue disorders. In this case study we describe a 19-year-old with a splenic artery aneurysm without known comorbidities.

Methods

This is an observational case study. A comprehensive chart review of the patient’s medical chart was conducted. A literature review of relevant materials was then conducted in order to evaluate for prevalence of disease and corrective management.

Results …


How Adverse Childhood Trauma Affects Coping Behaviors And Anxiety In College Students During Covid-19: A Neurobiological Perspective, Harshita Yepuri, Amanda Gilmore, Laura Carruth, Ruschelle Leone May 2025

How Adverse Childhood Trauma Affects Coping Behaviors And Anxiety In College Students During Covid-19: A Neurobiological Perspective, Harshita Yepuri, Amanda Gilmore, Laura Carruth, Ruschelle Leone

Research Day

The Coronavirus disease (COVID-19) pandemic has uprooted college students from the traditional college environment and placed additional stressors on them, yet its effects are still emerging. In the present study, 329 college students (Mage=19.74, SDage= 1.96) completed measures of generalized anxiety, behavioral coping, and adverse childhood experiences between July 2020 and March 2021 of the COVID-19 pandemic. It is hypothesized that more adverse childhood experiences would be associated with more maladaptive behavioral coping strategies. In addition, less adaptive coping strategies would be positively associated with more anxiety among college students. Results indicated that negative coping behaviors were associated with more …


Lymphoscintigraphy Use And Surgical Planning In Patients With Recurrent Ipsilateral Breast Cancer, Noah Mejias, Katie Pyrz, Kathleen Jeffery May 2025

Lymphoscintigraphy Use And Surgical Planning In Patients With Recurrent Ipsilateral Breast Cancer, Noah Mejias, Katie Pyrz, Kathleen Jeffery

Research Day

Background/Objective:

In recent literature, there has been a question of how to surgically manage patients with recurrent ipsilateral breast cancer due to the possibility of aberrant lymphatic drainage pattern secondary to a previous axillary lymph node dissection. The use of preoperative lymphoscintigraphy to map possible aberrant drainage patterns prior to surgery remains investigational, necessitating the need for further management guidelines.

Methods:

We identified two patients in our database with recurrent ipsilateral breast cancer and previous nodal surgery as well as lymphoscintigraphy showing focal uptake of radioactive tracer on the contralateral side.

Results:

Two patients presented with recurrent ipsilateral breast cancer. …


Recurrence Of Symptoms Following Conservative And Surgical Treatment For Lumbar Radiculopathy: A Literature Review, Aribah Ali, Tina Alkhazali, Robert Ablove May 2025

Recurrence Of Symptoms Following Conservative And Surgical Treatment For Lumbar Radiculopathy: A Literature Review, Aribah Ali, Tina Alkhazali, Robert Ablove

Research Day

Introduction: Lumbar radiculopathy is a common clinical problem and remains a controversial diagnosis at fundamental levels, including its diagnostic criteria, pathophysiology, and optimal treatment. Patients with lumbar radiculopathy may improve with either conservative or surgical treatment; the specific treatment chosen is based on patient preferences, priorities of care, and comorbidities. However, there is limited evidence from clinical studies to support treatment choice in daily practice. The purpose of this literature review is to summarize evidence regarding the recurrence of symptoms following conservative treatments and surgical treatments for patients with lumbar radiculopathy.

Methods: The review was conducted using the OneSearch database …


A Systemic Review Of Efficacy, Ratings And Top Football Gear For Concussion Prevention In 2024, Mustafa I. Ansari, Mutasem F. Shopon, Erik Zarandy May 2025

A Systemic Review Of Efficacy, Ratings And Top Football Gear For Concussion Prevention In 2024, Mustafa I. Ansari, Mutasem F. Shopon, Erik Zarandy

Research Day

Introduction: Concussions in football pose significant health risks, requiring the implementation of effective protective gear to reduce the incidence of head injuries. Helmets and mouthguards are standard equipment, but their true effectiveness remains debated.

Objective: This study aimed to systematically evaluate the efficacy of modern football protective gear, specifically helmets and mouthguards, in the prevention of concussions.

Methods: Following PRISMA guidelines, a comprehensive search was conducted in PubMed, Cochrane Library, Google Scholar, and Embase. A total of 3,894 studies were reviewed, and 35 studies met the inclusion criteria. Independent reviewers analyzed the studies to determine the impact of helmets and …