Medicine and Health Sciences Commons^™

Chronic Illness Education 2025: Lupus And Cardiovascular Disease Risk, Ahmad Almaat, Dina Bayachou, Halle Escher, Isabella Imirowicz, Myles Perry, Sherley Pagan Figueroa, Usman Siddiqui

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Pediatric Depression And Anxiety: Hope Through Healthcare, Andreas Mozny, Arjan Goenaga Castillo, Audrey Millar, Ebony Williams, Griffin Lotze, Haytham Al-Qasmi, Kamontip Jongnarangsin, Tricia Jain

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Improving Lifestyle Choices In Children Withtype-2 Diabetes Mellitus, David Williams, Hariharan Ramakrishnan, Luv Thakkar, Sanjana Kumar, Srikar Munukutla, Stephan Gonzalez, Taqwa Naas, Ted Hirschfield

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Resources To Improve Diabetes Mellitus In Adult Males, Abdul Naser Zamzami, David Echeverri, Isabella Costa, Musaed Al Rashidi, Pooja Menon, Xiaohan Zhan, Zain Abdun-Noor

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Improving The Understanding Of The Complexities Underlying Adult Obesity, Ethan Montoya, Maria Villalba, Morzouk Lawal, Nataliah Jwaida, Safa Razvi, Susan Lagrand, Vittal Ashwin Kandukuri, Robert Chalhoub

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Mitigation Of Cardiovascular Disease Risk Factors For Older Adults, Amber Hool, Benjamin Sun, Jacob Nielsen, Kevin Marzolf, Mariel Agbim, Nathan Beshai, Yusuf Hashem, Zahraa Ghosn

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Lifestyle Modification Resources For Cardiovascular Disease Risk Reduction, Ali Mustapha, Cheyenne Gonzales, Clara Devota, Emily Yao, Mahmood Alsughayer, Marcel Addis Jackson, Namrata Vedagarbha, Shane Tinsley

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Resources To Prevent Adolescent Hypertension, Anabelle Dally, Carlton Parker, Henry Ubaydi, Isabella Garcia, Joshua Mathews, Lila Tudrick, Michelle Brown, Ralph Durgham

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Barriers To Effective Diabetes Management In A Socioeconomically Disadvantaged Setting, Amaris Bradley, Karen Nakhla, Kyle Tsutsui, Mohamad Fardous, Saihaj Deol, William Frazier, Yeganeh Tabatabaei Alavi, Zackary Taylor

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Treatment, Resources, And Prevalence Of Depression Among Adolescents With Chronic Health Conditions, Daeho Kim, Elyse Vanderwoude, Francesca Settineri, James Moss, Karen Crile, Matthew Mellor, Rachele Willard, Sarah Farhat

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Hypertension Prevention Strategies Catered Towards Pre-Menopausal Women, Jack Summers, Juan Rios, Karli Monahan, Lara Thomas, Leah Abdallah, Noah Ramirez, Noor Ghanam, William Merchun

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Environmental And Psychosocial Interventions In Adolescent Depression, Christian Hausner, Deanna Brown, Erica Kruszewski, Mawadda Abdelhai, Mukund Jayaraju, Sabryn Leidlein, Trentin Ines, Tyrnan Mcgowan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: A Highly Misunderstood, Multifactorial Disease, Alexa Maruszewski, Ali Eidy, Chelsea Kumi, Hailey Hartmann, Jacob Pawlowski, Kinan Suliman, Laura Garcia, William Davie

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Preventative Measures To Mitigate The Development Of Atherosclerotic Coronary Artery Disease, Alexander Orr, Celina Wu, Elijah Marquez, Fateh Ahmad, Kendyll Gartrelle, Logan Harrison, Mia Sooch, Zahra Chehab, Emilio Espinal

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Local Action, Lower Pressure- Resources To Advocate For Improvement In Hypertension Within The Community, Carinne Jarvis, Elinor Harrison, George Yalamanchili, Kamakashi Sharma, Mackenzie Fitzgerald, Neel Lachhwani, Nimr Assaf, Richard Tuttle

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Resources To Improve Risk Of Hypertension, Bruna Storch Dos Santos, Bryce Brophy, Chonling Liu, Emily Webber, Izzy Havis, Janet Brenya, Noma Imudia, Eli Jarjous

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: School-Centered Interventions To Address Childhood Obesity, Aaron Yang, Amanda York, James Mcknight, Madison Jordan, Myron Shaba, Riley Marchin, Rita Pisegna, Constantine Tangalos

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Emotional And Behavioral Concerns With Limited Support, Ahmed Alzubaidi, Ambrielle Stoltz-Bango, Grace Doakes, Ikenna Oduocha, Isaak Miller, Kelly-Ozze Bollou, Marta Haireek, Wyatt Feldman

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Education And Resources To Improve Pediatric Type I Diabetes Mellitus Care Within Schools And Child Care Services, Alexander Seidel, Alexandra Thomas, Christine Larrea, Daven Sarikonda, Jack Gurwin, Maria Karla Bermudez Pineiro, Matthew Mello, Sana Soman

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Navigating Depression And Anxiety Amid Socioeconomic Strain, Afrah Ansari, Candice Miller, Elizabeth Heinz, Joshua Teso, Muhammad Idrees, Omolola Suleiman, Sospeter Machani, Celia Somers

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Depressive Symptoms And Treatment Hesitancy In A Middle-Aged Male Living Alone, Abdulrahman Altatan, Abigail Biddix, Joseph Kunnappilly, Katherine Zhang, Kehinde Bolaji, Kyrillos Ayoub, Maya Fajardo, Michael Niculcea

Patient Education Projects

No abstract provided.

Extubation Decisions With Predictive Information For Mechanically Ventilated Patients In Icu, Guang Cheng, Jingui Xie, Zhichao Zheng, Haidong Luo, Oon Cheong Ooi

Research Collection Lee Kong Chian School Of Business

Weaning patients from mechanical ventilators is a crucial decision in intensive care units (ICUs), significantly affecting patient outcomes and the throughput of ICUs. This study aims to improve the current extubation protocols by incorporating predictive information on patient health conditions. We develop a discrete-time, finite-horizon Markov decision process with predictions of future state to support extubation decisions. We characterize the structure of the optimal policy and provide important insights into how predictive information can lead to different decision protocols. We demonstrate that adding predictive information is always beneficial, even if physicians place excessive trust in the predictions, as long as …

Heterogeneous Impacts For Malaria Control From Larviciding Across Villages And Considerations For Monitoring And Evaluation, Ellie Sherrard-Smith, Ulrike Fillinger, Jean Philippe B. Tia, Peter Winskill, Benjamin G. Koudou, Emile S.F. Tchicaya, Antoine Sanou, Fredros Okumu, Mercy Opiyo, Silas Majambere, Arran Hamlet, Giovanni Charles, Ben Lambert, Thomas S. Churcher

All Peer-Reviewed Publications

Malaria vector control tools currently focus on insecticide treated nets (ITNs) and indoor residual spraying in malaria-endemic locations, but additional preventative strategies are needed to address protection gaps. Larval source management (LSM) includes larvicide application to aquatic habitat and an array of alternative forms of environmental efforts. An individual-based transmission model for falciparum malaria is used to demonstrate the theoretical benefit of suppressing malaria adult mosquito vector densities through LSM. The model simulates results of epidemiological trials from Western Kenya (a hilly area with papyrus swamps adjacent to human settlements and moderate to high perennial malaria transmission) and Côte d’Ivoire …

Autologous T Cell Therapy For Prame, Martin Wermke, Dejka M Araujo, Manik Chatterjee, Apostolia M Tsimberidou, Tobias A W Holderried, Amir A Jazaeri, Ran Reshef, Carsten Bokemeyer, Winfried Alsdorf, Katrin Wetzko, Peter Brossart, Katrin Aslan, Linus Backert, Sebastian Bunk, Jens Fritsche, Swapna Gulde, Silvana Hengler, Norbert Hilf, Mohammad B Hossain, Jens Hukelmann, Mamta Kalra, Delfi Krishna, M Alper Kursunel, Dominik Maurer, Andrea Mayer-Mokler, Regina Mendrzyk, Ali Mohamed, Karine Pozo, Arun Satelli, Marilena Letizia, Heiko Schuster, Oliver Schoor, Claudia Wagner, Hans-Georg Rammensee, Carsten Reinhardt, Harpreet Singh-Jasuja, Steffen Walter, Toni Weinschenk, Jason J Luke, Cedrik M Britten

Faculty, Staff and Student Publications

In contrast to chimeric antigen receptor T cells, T cell receptor (TCR)-engineered T cells can target intracellular tumor-associated antigens crucial for treating solid tumors. However, most trials published so far show limited clinical activity. Here we report interim data from a first-in-human, multicenter, open-label, 3 + 3 dose-escalation/de-escalation phase 1 trial studying IMA203, an autologous preferentially expressed antigen in melanoma (PRAME)-directed TCR T cell therapy in HLA-A*02+ patients with PRAME+ recurrent and/or refractory solid tumors, including melanoma and sarcoma. Primary objectives include the evaluation of safety and tolerability and the determination of the maximum tolerated dose (MTD) and/or recommended dose …

Memantine Inhibits Calcium-Permeable Ampa Receptors, Elisa Carrillo, Alejandra Montaño Romero, Cuauhtemoc U Gonzalez, Andreea L Turcu, Santiago Vázquez, Edward C Twomey, Vasanthi Jayaraman

Faculty, Staff and Student Publications

Memantine is an US Food and Drug Administration (FDA) approved drug that is thought to selectively inhibit NMDA-subtype of ionotropic glutamate receptors (NMDARs). NMDARs enable calcium influx into neurons and are critical for normal brain function. However, increasing evidence shows that calcium influx in neurological diseases is augmented by calcium-permeable AMPA-subtype ionotropic glutamate receptors (AMPARs). Here, we demonstrate that these calcium-permeable AMPARs (CP-AMPARs) are inhibited by memantine. Electrophysiology unveils that memantine inhibition of CP-AMPARs is dependent on their calcium permeability and the presence of their neuronal auxiliary subunit transmembrane AMPAR regulatory proteins (TARPs). Through cryo-electron microscopy we elucidate that memantine …

Hernia Recurrence Risk Matters More Than Mesh Type To Patients Undergoing Ventral Hernia Repair, Stephanie Martinez Ugarte, Mokunfayo O Fajemisin, Chelsea J Guy-Frank, Dalya M Ferguson, Jonah J Stulberg, Lillian S Kao, Julie L Holihan

Faculty, Staff and Student Publications

Introduction: Patients' perceptions about synthetic mesh for ventral hernia repair (VHR) may stem from a lack of knowledge of risks. We assessed patients' threshold for accepting the risk of hernia recurrence to avoid synthetic mesh.

Methods: Patients ≥18 y old with prior or upcoming VHR viewed a one-time video decision aid describing recurrence risk with biologic versus synthetic mesh. Patients chose between these options using a probability trade-off (PTO) technique, varying hernia recurrence rate with biologic mesh. Based on randomized trials, the recurrence rate using synthetic mesh was 9%. The PTO score was the recurrence rate (0%-100%) at which patients …

Outcomes And Toxicity Following 3 Or More Definitive Courses Of Thoracic Radiation Therapy For Non-Small Cell Lung Cancer, Abigael Odwuor, Percy Lee, Joe Y Chang, Saumil Gandhi, Zhongxing Liao, Steven H Lin, Aileen Chen, Quynh-Nhu Nguyen, Michael S O'Reilly, Stephen G Chun, Julianna Bronk, David Qian, Matthew S Ning

Faculty, Staff and Student Publications

Purpose: Salvage re-irradiation is increasingly utilized to manage non-small cell lung cancer (NSCLC) locoregional recurrence or new lung primaries in previously treated areas. There is sparse information on efficacy and toxicity profile. We report a large experience of patients treated with multiple courses of definitive radiation for new and recurrent NSCLC.

Methods and materials: Medical records of patients who underwent ≥ 3 definitive thoracic radiation therapy (RT) courses for new or recurrent NSCLC at our cancer center from 2012 through 2021 were retrospectively reviewed following institutional review board approval. Toxicity was graded per Common Terminology Criteria for Adverse Events (CTCAE) …

Oatp1b1/1b3 Deficiency Exacerbates Hyperbilirubinemia In Erythropoietic Protoporphyria, Ruizhi Gu, Fu-Ying Qin, Luxuan Wang, Jiaojiao Zhang, Jacob Emerson, Qing Ma, Jie Lu, Karl E Anderson, Junmei Wang, Xiaochao Ma

Faculty, Staff and Student Publications

Erythropoietic protoporphyria (EPP) is caused by loss-of-function mutations in ferrochelatase (FECH), leading to the accumulation of its substrate, protoporphyrin IX (PPIX). PPIX is primarily produced in the bone marrow and transported to the liver for excretion. Because PPIX is hydrophobic, its elevated levels can cause bile duct blockage, cholestatic liver injury, and even liver failure. However, the specific transporter responsible for PPIX uptake into hepatocytes remains unclear. The OATP1B1/1B3 transporters, which are expressed in hepatocytes, facilitate the uptake of coproporphyrin III, a structural analog of PPIX. Additionally, OATP1B1/1B3 mediates the uptake of bilirubin, a biomarker of liver injury, from plasma …

Histone Lysine Methyltransferases Mll3 And Mll4 Direct Gene Expression To Produce Platelets Efficiently, Guozhen Gao, Josimar Dornelas Moreira, Prosun Das, Kevin Lin, Kai Ge, Taiping Chen, Yue Lu, Margarida A Santos

Faculty, Staff and Student Publications

Circulating blood platelets are responsible for maintaining hemostasis. They are released into blood vessels from mature megakaryocytes. Although several transcription factors have been reported to orchestrate the transcriptional programs required for platelet production, how chromatin regulators control these processes is still poorly understood. MLL3 and MLL4 are the main lysine methyltransferases responsible for the deposition of H3K4me1 histone marks at enhancers. MLL3 and MLL4 typically form complexes with other co-factors, such as PTIP. Recently, we showed that loss of PTIP leads to decreased platelet numbers in mice. Here, we find that, although MLL3/4 double deficiency does not alter megakaryopoiesis and …

Heat Shock Induces Alternative Polyadenylation Through Dynamic Dna Methylation And Chromatin Looping, Emily E Fink, Yi Zhang, Briana Santo, Anwita Siddavatam, Rosie Ou, Vishal Nanavaty, Byron H Lee, Angela H Ting

Faculty, Staff and Student Publications

Alternative cleavage and polyadenylation (APA) is a gene regulatory mechanism used by cells under stress to upregulate proteostasis-promoting transcripts, but how cells achieve this remains poorly understood. Previously, we elucidated a DNA methylation-regulated APA mechanism, in which gene body DNA methylation enhances distal poly(A) isoform expression by blocking CCCTC-binding factor (CTCF) binding and chromatin loop formation at APA control regions. We hypothesized that DNA methylation-regulated APA is one mechanism cells employ to induce proteostasis-promoting poly(A) isoforms. At the DNAJB6 cochaperone locus, acute heat shock resulted in binding of stress response transcription factors heat shock factor 1, ATF6, and YY1 at …