Medicine and Health Sciences Commons^™

Shp2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy To Cancer Treatment And Vascular Risk, Silvia Fernanda López Moreno, Stefania Assunto Lenz, Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Jung Hyun Kim, Nicolas L Palaskas, Kevin T Nead, Venkata S K Samanthapudi, Gilbert Mejia, Oanh Hoang, Jonghae Lee, Steven H Lin, Joerg Herrmann, Guangyu Wang, Syed Wamique Yusuf, Cezar A Iliescu, Noah I Beinart, Charlotte Manisty, Masuko Ushio-Fukai, Tohru Fukai, Pietro Ameri, Roza I Nurieva, Michelle A T Hildebrandt, Keri Schadler, Efstratios Koutroumpakis, Sivareddy Kotla, Nhat-Tu Le, Jun-Ichi Abe

Faculty, Staff and Student Publications

Src homology 2-domain containing protein tyrosine phosphatase 2 (SHP2), encoded by the Ptpn11 gene (Tyrosine-protein phosphatase non-receptor type 11), is a key downstream effector of PD-1/PD-L1 signaling and is likely important, in addition to immune modulation, in tumor development and vascular homeostasis. SHP2 conveys PD-1 mediated inhibitory signaling in T cells, and is emerging as a therapeutic target. Importantly, there is an association between immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs), and cardiovascular complications, underscoring the need to understand SHP2’s role in these processes. This review aims to summarize current knowledge on SHP2/PTPN11 biology, its role in immune …

The Effect Of Uterine Entry Technique On Chorioamniotic Membrane Separation In Fetoscopic Laser Photocoagulation For Twin-To-Twin Transfusion Syndrome: Protocol For A Randomized Controlled Trial, Brian A Burnett, Jessian L Munoz, Rebecca M Johnson, Christian M Parobek, Luis E Delgadillo Chabolla, Cara Buskmiller, Roopali V Donepudi, Magdalena Sanz Cortes, Michael A Belfort, Ahmed A Nassr

Faculty, Staff and Students Publications

Background: Chorioamniotic membrane separation (CAS) is a recognized complication of fetoscopic laser photocoagulation (FLP) for twin-to-twin transfusion syndrome (TTTS), associated with increased risks of preterm prelabor rupture of membranes (PPROM) and preterm birth (PTB). Although CAS is well described, its incidence and relationship to specific surgical techniques, particularly the method of uterine entry, are not well defined in the published literature. No randomized trials have evaluated whether entry technique influences the risk of CAS.

Methods: We present the protocol for a randomized controlled trial comparing sharp-trocar and Seldinger uterine entry techniques for FLP in TTTS diagnosed between 16 + 0 …

Deletion Of Fibro-Adipogenic Progenitors-Specific Follistatin Impairs Muscle Function And Accelerates Skeletal Muscle Atrophy In Obese Mice, Muhammad Rahil Aslam, Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Shinya Abe, Nguyen Quynh Phuong, Memoona, Sana Khalid, Le Duc Anh, Ayumi Nishimura, Yoshiyuki Watanabe, Yoshiko Igarashi, Naeem Iqbal, Maki Yokoyama, Yasuhiro Onogi, Kennichi Hirabayashi, Hiroyuki Miwa, Takumi Era, Martin M Matzuk, Seiji Yamamoto, Koichi Ikuta, Isao Usui, Kohta Kobayashi, Toshihiko Satake, Masaru Kato, Shiho Fujisaka, Kazuyuki Tobe

Faculty, Staff and Students Publications

Background: Follistatin is a potent regulator of various TGF-β superfamily members, including myostatin (MSTN) and activin A. Previous studies have shown that follistatin is crucial in enhancing myogenesis during acute muscle injury. The mechanism by which fibro-adipogenic progenitors (FAPs)-specific follistatin influences muscle homeostasis in obese mice remains unknown. Therefore, we investigated the physiological role of follistatin in PDGFRα-positive FAPs in the regulation of muscle homeostasis and exercise in obese mice.

Methods: A PDGFRα-specific follistatin knockout (follistatin KO) mouse model was generated using PDGFRα-GFP-CreERT2 (PDGFRα-GCE) and follistatinflox/flox mice. These mice were fed a 60% high-fat diet (HFD) for 20 weeks, followed …

Alteration Of Gut Microbial Ecology By The Direct Activation Of The Brain: Inverse Gut-Microbiome-Brain Dynamics, I-Ching Wang, Jessica L Swanson, Jillian L Waters, Mikhail Y Kochukov, Shelly A Buffington, Sean W Dooling, Benjamin R Arenkiel, Mauro Costa-Mattioli

Faculty, Staff and Students Publications

The gut-microbiome-brain axis is a bidirectional communication system influencing host physiology and overall fitness. While "bottom-up" effects-where gut microbes influence brain function and behavior-are well established, direct evidence for "top-down" modulation-where the brain shapes the gut microbial ecology-remains elusive. Here, we show that the selective expression of the bacterial ion channel mNaChBac in glutamatergic lateral habenula (LHb) neurons increases their bursting activity and leads to endophentypes associated with depression. Importantly, this chronic activation leads to changes in the gut microbiome composition over time, as reflected by shifts in alpha-diversity and alterations in specific microbial taxa. These findings provide direct evidence …

A Cluster-Randomized Controlled Trial Assessing The Effectiveness Of A Multifaceted Versus A Discrete Implementation Strategy On Fidelity To An Occupational Guideline For The Prevention Of Mental Health Problems At The Workplace: A Dual Perspective From Swedish Schools, Andreas Rödlund, Anna Toropova, Rebecca Lengnick-Hall, Byron J Powell, Liselotte Schäfer Elinder, Christina Björklund, Lydia Kwak

2020-Current year OA Pubs

BACKGROUND: Although the management of psychosocial risks in the work environment represents an evidence-based approach to the prevention of mental health problems, its implementation is limited, including in schools, and knowledge on how to support better implementation is scarce. This study compares the effectiveness of a multifaceted vs. a discrete implementation strategy on fidelity to an occupational guideline for the prevention of mental health problems. Dual perspectives were used to assess fidelity, an important aspect of the measurement agenda.

METHODS:  A cluster-randomized controlled trial was conducted among 55 schools in Sweden. A multifaceted strategy (educational meeting, implementation teams, ongoing training, …

Norms For Scaling Up Small And Sick Newborn Care: An Overview Of Reviews, Natalie A. Strobel, Georgia Whisson, Derek Swe, Amy Budrikis, Karen M. Edmond

Research outputs 2022 to 2026

Background: The World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) currently have no benchmarks or 'norms' for scaling up small and sick newborn (SSN) service delivery in health facilities in low- and middle-income countries (LMICs). Our objective was to understand which systematic reviews had addressed the following norms in the last five years: number of SSN beds per live births in a district or similar administrative unit (admission beds); space requirements for SSN units, including mother-infant dyads (space); health workforce ratios in SSN units (workforce); and travel time to health facilities with SSN units (travel time). Methods: …

Third Grade Reading Proficiency In Deaf/Hard Of Hearing Children Who Received Early Intervention, Jareen Meinzen-Derr, Cassandra Conrad, Mekibib Altaye, Elodie Betances, Jayna Schumacher, Susan Wiley

Journal of Early Hearing Detection and Intervention

Background

Early enrollment in Part C Early Intervention (EI) by age 6 months is linked to improved language and kindergarten readiness in deaf or hard of hearing (DHH) children, but its effect on later academic outcomes is unclear. This study examines whether earlier (<6 months) or later (>6 months) enrollment influences third-grade reading proficiency.

Method

This study used data linked from three Ohio state agencies for infants identified with permanent hearing loss born 2008-2014 who received EI; 412 had third grade standardized reading tests. Reading levels were categorized from limited to advanced. Logistic regression assessed the association between enrollment timing and reading proficiency, …

The Radical Middle: Caregiver Beliefs About Language Access For Deaf And Hard Of Hearing Children, Monica Zmudzinski, Krystal L. Werfel

Journal of Early Hearing Detection and Intervention

The purpose of this study was to explore the communication choices of caregivers of deaf or hard of hearing (DHH) children. Specifically, we explored what communication options caregivers were presented with, identify what factors impacted a caregiver’s decision to pursue spoken language, and identify what barriers exist to learning sign language. We conducted semi-structured interviews with 20 caregivers of DHH children who had decision making power at the time of their child’s diagnosis. Transcripts were coded using an inductive approach with triangulation between authors. Many families reported that minimal to no information was provided about communication options at the time …

Evaluating Preschoolers Who Are Deaf/Hard Of Hearing Using Listening And Spoken Language To Determine Special Education Eligibility, Kameron C. Carden, R. A. Mcwilliam

Journal of Early Hearing Detection and Intervention

The aim of this study was to increase understanding of evaluation practices used when determining special education eligibility for preschoolers who are deaf/hard of hearing (DHH) using listening and spoken language (LSL), particularly during the early intervention to preschool transition. Specifically, we explored alignment of school-based practices with recommended practices from the National Association of State Directors of Special Education (NASDSE, 2018). An online survey was distributed to school-based special educators, including speech-language pathologists (SLPs), special education teachers, and teachers of the deaf within the United States that included a) evaluation practices, b) eligibility requirements, and c) practice demographics. Participant …

Developing A Research Agenda In Partnership With Parents Of Deaf/Hard-Of-Hearing Children, Carrie A. Davenport, Ursula M. Findlen, Ann Schenk Mcalearney, Lisa Vaughn

Journal of Early Hearing Detection and Intervention

Background: Community-based participatory research (CBPR) is an excellent fit for understanding and addressing the unique and diverse needs of deaf or hard-of-hearing (DHH) children and their families.

Objectives: We describe lessons learned from a capacity building project initiating an academic-community partnership between a multidisciplinary research team and a small group of parents of DHH children. Trainings and focus group style discussions created a research agenda reflective of families’ priorities.

Methods: Processes are described related to the development and composition of a Family Advisory Council, training topics and methods, the process for generating and prioritizing topics, and evaluation procedures.

Lessons learned: …

The Follow-Up Gap: Racial Disproportionality And Social Determinants Of Health In New Jersey’S Hearing Detection And Intervention Program, Maryrose Mcinerney, Wendy Zeitlin

Journal of Early Hearing Detection and Intervention

Objectives. To assess how race/ethnicity and social determinants of health are related to loss to follow-up (LTF) from NJ’s Early Hearing Detection and Intervention (EHDI) program.

Methods. All infants born in NJ between June 2015 and June 2017 referring for additional hearing healthcare after hospital discharge were considered for inclusion in this study. The sample consisted of 4,141 babies, 10.7% of which received no follow-up care. Step-wise multi-level logistic regression was used to determine how race/ethnicity, family-level, and community-level social determinants of health (SDOH) were predictive of LTF.

Results. In each model, the odds of being LTF were significantly higher …

Opportunities To Improve Continuity In Medicines Management For Aboriginal And Torres Strait Islander People Accessing Care In South Australian Hospitals: Coverage, Quality, Monitoring And Accountability, Annabelle Cranwell, Cheyne Sullivan, Kezia Daniel, Erik Cornelisse, Brianna Kinnear

Journal of the Australian Indigenous HealthInfoNet

This paper proposes that hospital admissions, which are traditionally considered high risk transitions, can be opportunities to strengthen continuity in medicines management (CMM) for Aboriginal and Torres Strait Islander patients and across the healthcare system. There are four key areas of focus in this paper including CMM coverage, CMM quality, health system monitoring of CMM, and health system accountability for CMM to Aboriginal and Torres Strait Islander people and communities. These areas for improvement are justified by the National Agreement on Closing the Gap (The National Agreement), the Guiding Principles to Achieving continuity in medication management, and Continuity in Medication …

Bridging Traditions: A Mixed Methods Systematic Review Of Yoga For Trauma Recovery In Indigenous People, Andreia Schineanu, Fredrik Velander, Julaine Allan

Journal of the Australian Indigenous HealthInfoNet

Objective: The aim of this mixed methods systematic review was to explore if Yoga can alleviate mental health issues for Indigenous people, and how participants experience the effects.

Methods: Peer-reviewed primary research published in English retrieved from 2002 to March 2024 was identified using the databases Medline, Scopus, Informit, ProQuest and PsycINFO. Qualitative, quantitative and mixed method studies with Indigenous populations, where the primary intervention was Yoga or mindfulness programs with significant yoga components that reported on mental health outcomes were included.

Results: Only 5 studies met the inclusion criteria. The studies demonstrated significant improvements in mental health outcomes, including …

Hpv Prevention In Men: A Narrative Review Of Strategies, Risks, And Public Health Implications, Martin S. Lipsky, Bayler Gunnell, Justin Nguyen, Samantha Lee, Geo Wolfe, Man Hung

Institute on Aging Publications

Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide, impacting both males and females. In men, HPV causes genital warts, more than 90% of anal cancers, and 60% of oropharyngeal cancers. Given that one in three men are infected with HPV worldwide, there is a pressing need for enhanced public health strategies focusing on prevention. This comprehensive narrative review presents an overview of HPV in men, key risk factors, and primary prevention in men. The most effective preventive measure for HPV in males is vaccination. Males at high risk for HPV include those who smoke, have human immunodeficiency …

Incivility Experienced By Males In Nursing Education, Christopher S. Hale

MUSC Theses and Dissertations

Background: Nursing shortages are exacerbated by unhealthy learning environments. Men remain underrepresented among nursing students and faculty, yet their experiences of incivility are rarely examined.

Purpose: Guided by Clark’s Model of Civility in Nursing Education, this dissertation explored how male nursing students and educators in U.S. prelicensure programs experience incivility and how these patterns inform strategies to promote civility and retention.

Methods: This compendium includes (a) an integrative review of nursing faculty mistreatment using Whittemore and Knafl’s method; (b) a cross-sectional survey of male nursing educators and students using the Incivility in Nursing Education–Revised (INE-R) to estimate the prevalence and …

Understanding The Lived Experience Of Mental Health Following An Alpha-Gal Syndrome Diagnosis: A Phenomenological Study Grounded In Maslow’S Hierarchy Of Needs, Heather L. Hargis

Dissertations

Alpha-gal syndrome is a tick-borne food allergy that triggers delayed allergic reactions to mammalian products and profoundly alters daily life. While growing research examines the physiological aspects of alpha-gal syndrome, little is known about its psychological impact. This phenomenological study explored the lived experiences of individuals with alpha-gal syndrome to understand how the condition influences mental health through the lens of Maslow’s Hierarchy of Needs. Data was collected through semi-structured virtual interviews with adults medically diagnosed with alpha-gal syndrome. Thematic analysis revealed significant challenges in meeting Maslow’s lower-tier needs—physiological, safety, and love/belonging—due to dietary restrictions, medical uncertainty, social isolation, and …

Unveiling The Clinical Profiles Of Critically Ill Covid-19 Patients: Insights From Ezhou During The Early Spread, Guohui Yang, Zewen Liu, Tabitha Abraham, Linwei Li, Tingyang Zhou, Qing Zhang, Li Zuo

School of Medicine Publications

The coronavirus disease 2019 (COVID-19) started in December 2019 in Wuhan. This article evaluated clinical characteristics, and imaging manifestations in Ezhou, an early locked-down city, 80 kilometers east of Wuhan. We analyzed data from 98 confirmed severe COVID-19 patients in Ezhou Central Hospital between February 1st and March 22nd, 2020. We compared patients' laboratory results, imaging manifestations, and treatments between survival and death groups. Of these 98 confirmed COVID-19 patients, 24 individuals (24.6%) had chronic diseases. The main symptoms of critically ill patients were fever (86.7%), cough (83.7%), and dyspnea (59.1%). Common complications were acute respiratory distress syndrome (ARDS; 49%), …

Alcohol Use Disorder, Kendall Walker, James Mcnary, Hamilton Farris

School of Medicine Faculty Publications

No abstract provided.

Semaglutide Use Before Single-Level Lumbar Fusion Associated With Fewer Readmissions And 90-Day Costs, Mitchell K. Ng, Paul G. Mastrokostas, Ariel N. Rodriguez, Abigail Razi, Leonidas E. Mastrokostas, Ahmed K. Emara, Brian T. Ford, Jacquelyn J. Xu, Jonathan Dalton, Rajkishen Narayanan, Christopher K. Kepler, Alan S. Hilibrand, Alex R. Vaccaro, Jad Bou Monsef, Afshin E. Razi

Rothman Institute Papers

CONTEXT: Semaglutide, a glucagon-like protein-1 receptor agonist used in diabetes and obesity management, has demonstrated perioperative benefits in other surgical populations. However, its role in spine surgery remains unclear.

AIMS: This study aims to evaluate whether patients undergoing single-level lumbar fusion demonstrate: (1) fewer medical complications; (2) surgical complications; and (3) healthcare utilization as measured by readmissions and costs.

SETTINGS AND DESIGN: A retrospective cohort study using a national claims database from 2010 to 2021.

SUBJECTS AND METHODS: Patients with diabetes mellitus undergoing single‑level lumbar fusion were identified and matched 1:5 using propensity scores based on age, sex, body mass …

Challenges In Postoperative Compliance And Follow-Up Among Trauma Patients: A Case Report Of A Trans-Scaphoid Perilunate Dislocation, Paul Bonilla, Anesu K. Murambadoro, Chloe Harris, Sergio Rodriguez

School of Medicine Publications

The wrist joint is a complex articulation that involves the distal radius, ulna, eight carpal bones (scaphoid, lunate, triquetrum, pisiform, trapezium, trapezoid, capitate, and hamate), and the bases of the metacarpals. Trans-scaphoid perilunate fracture-dislocations are complex wrist injuries, most commonly resulting from high-energy mechanisms involving hyperextension and ulnar deviation. Prompt diagnosis and surgical management are essential in restoring wrist function and stability. This report focuses on the case of a 28-year-old male who sustained a trans-scaphoid perilunate dislocation with multiple associated fractures after an all-terrain vehicle (ATV) rollover accident. Surgical intervention included median nerve decompression, open reduction and internal fixation …

Exploring The Acceptability Of The Kimberley Mum’S Mood Scale For Perinatal Mental Health Screening In Gove District Hospital, North-East Arnhem Land, Tom P. Atkinson, Erica P. Spry, David Atkinson, Julia V. Marley, Emma Carlin

Journal of the Australian Indigenous HealthInfoNet

Objective: Across Australia perinatal mental health challenges disproportionately impact Aboriginal women. Identifying Aboriginal women at risk of adverse mental health outcomes in the perinatal period is an important step in supporting their overall health and wellness. Current screening tools have significant limitations when used with Aboriginal women.

The Kimberley Mums Mood Scale (KMMS) is a culturally secure approach to screening for perinatal mental health disorders in Aboriginal women. It has been validated in the Kimberley region of Western Australia and may be able to improve mental health screening in other regions. In this study the KMMS was trialled at a …

Dimensions Of Queens Culture / The Personality Of Queens, Claudia Brumbaugh

Open Educational Resources

1. Description of the resource: This assignment will be given early in the semester, and will be due near the end of the semester, scaffolded into steps over the semester:
   1. Via descriptive writing, define one of five, cultural dimensions / Big 5 traits. Then, define the dimension / trait in terms of the local conditions in Queens (e.g., what it means more specifically in the context of Queens).* You can pick the level of analysis for “Queens”. It could be QC, or neighborhood, or the entire borough. Next, place your level of Queens analysis into historical context, describing past movements/events, and …

Nirsevimab Effectiveness Against Intensive Care Unit Admission For Respiratory Syncytial Virus In Infants - 24 States, December 2024-April 2025, Laura D. Zambrano, Regina M. Simeone, Margaret M. Newhams, Amanda B. Payne, Natasha B. Halasa, Amber O. Orzel-Lockwood, Jemima M. Calixte, Satoshi Kamidani, Hillary Crandall, Melissa A. Cameron, Jennifer E. Schuster, Aline B. Maddux, Kathleen Chiotos, Katherine Irby, Steven L. Shein, Mary Allen Staat, Lora M. Martin, Samina S. Bhumbra, Ryan A. Nofziger, Jigar C. Chauhan, Danielle M. Zerr, Shira J. Gertz, Judith A. Guzman-Cottrill, Michele Kong, Janet R. Hume, Bria M. Coates, Kelly N. Michelson, Tamara T. Bradford, Et Al

School of Medicine Faculty Publications

Respiratory syncytial virus (RSV) is a leading cause of intensive care unit (ICU) admission and respiratory failure among infants (children aged < year) in the United States. In August 2023, CDC’s Advisory Committee on Immunization Practices recommended nirsevimab, a long-acting monoclonal antibody, to protect against RSV-associated lower respiratory tract infection among all infants aged < 8 months born during or entering their first RSV season. Following licensure, nirsevimab effectiveness has been demonstrated against RSV-associated infant hospitalization, but evidence regarding effectiveness against RSV-associated critical illness is limited. In a 27-hospital case-control investigation, nirsevimab effectiveness against both RSV-associated infant ICU admission and acute respiratory failure (illness requiring continuous positive airway pressure, bilevel positive airway pressure, or invasive mechanical ventilation) after hospital admission was evaluated during December 1, 2024-April 15, 2025. Among 457 case-patients who received a positive RSV test result and 302 control patients who received a negative RSV test result admitted to an ICU with respiratory symptoms, 14% and 45%, respectively, had received nirsevimab ≥ 7 days before symptom onset. Nirsevimab was 80% effective (95% CI = 70%-86%) against RSV-associated ICU admission and 83% effective (95% CI = 74%-90%) against acute respiratory failure when received a median of 52 days (IQR = 32-89 days) and 50 days (IQR = 32-86 days) before onset for each respective endpoint. These estimates support the recommendation for use of nirsevimab as a prevention strategy to protect infants against severe outcomes from RSV infection.

Providencia Rettgeri As An Unusual Pathogen In Diabetic Foot Osteomyelitis: A Case Report And Literature Review, Stephanie N. Campbell, Madeleine Mehaffey, Nikita Gambhir, Amanda L. Killeen

School of Podiatric Medicine Publications

Providencia rettgeri is a Gram-negative bacterium, rarely reported as a cause of diabetic wound infections. Its frequent resistance to β-lactams and carbapenems limits treatment options, especially in immunocompromised patients. We present the case of a 59-year-old unhoused male living with diabetes, peripheral artery disease, and prior bilateral transmetatarsal amputations who presented with a University of Texas 3B diabetic foot ulcer. Magnetic resonance imaging showed osteomyelitis of metatarsals 2–4, and bone biopsy grew Providencia rettgeri and Proteus mirabilis. The patient declined further surgery and was treated with 6 weeks of cefepime and metronidazole, with outpatient wound care, achieving wound closure …

Nirsevimab Effectiveness Against Intensive Care Unit Admission For Respiratory Syncytial Virus In Infants - 24 States, December 2024-April 2025., Laura D. Zambrano, Regina M. Simeone, Margaret M. Newhams, Amanda B. Payne, Natasha B. Halasa, Amber O. Orzel-Lockwood, Jemima M. Calixte, Satoshi Kamidani, Hillary Crandall, Melissa A. Cameron, Jennifer E. Schuster, Aline B. Maddux, Kathleen Chiotos, Katherine Irby, Steven L. Shein, Mary Allen Staat, Lora M. Martin, Samina S. Bhumbra, Ryan A. Nofziger, Jigar C. Chauhan, Danielle M. Zerr, Shira J. Gertz, Judith A. Guzman-Cottrill, Michele Kong, Janet R. Hume, Bria M. Coates, Kelly N. Michelson, Emily R. Levy, Tamara T. Bradford, Stephanie P. Schwartz, Tracie C. Walker, Melissa S. Stockwell, Austin Biggs, Alexander H. Hogan, Katherine Lindsey, Angela P. Campbell, Adrienne G. Randolph, Overcoming Rsv Investigators

Manuscripts, Articles, Book Chapters and Other Papers

Respiratory syncytial virus (RSV) is a leading cause of intensive care unit (ICU) admission and respiratory failure among infants (children aged < 1 year) in the United States. In August 2023, CDC's Advisory Committee on Immunization Practices recommended nirsevimab, a long-acting monoclonal antibody, to protect against RSV-associated lower respiratory tract infection among all infants aged < 8 months born during or entering their first RSV season. Following licensure, nirsevimab effectiveness has been demonstrated against RSV-associated infant hospitalization, but evidence regarding effectiveness against RSV-associated critical illness is limited. In a 27-hospital case-control investigation, nirsevimab effectiveness against both RSV-associated infant ICU admission and acute respiratory failure (illness requiring continuous positive airway pressure, bilevel positive airway pressure, or invasive mechanical ventilation) after hospital admission was evaluated during December 1, 2024-April 15, 2025. Among 457 case-patients who received a positive RSV test result and 302 control patients who received a negative RSV test result admitted to an ICU with respiratory symptoms, 14% and 45%, respectively, had received nirsevimab ≥7 days before symptom onset. Nirsevimab was 80% effective (95% CI = 70%-86%) against RSV-associated ICU admission and 83% effective (95% CI = 74%-90%) against acute respiratory failure when received a median of 52 days (IQR = 32-89 days) and 50 days (IQR = 32-86 days) before onset for each respective endpoint. These estimates support the recommendation for use of nirsevimab as a prevention strategy to protect infants against severe outcomes from RSV infection.

Queens Mindscapes: A Digital Field Research Project, Shonelle George

Open Educational Resources

This Open Educational Resource (OER) is designed for an undergraduate Introduction to General Psychology course at Queens College, CUNY. Titled “Queens Mindscapes: A Digital Field Research Project,” this assignment is part of a module that engages students in real-world psychological research grounded in the diverse communities of Queens, New York. Drawing from the Noba module from the course textbook, “Conducting Psychology Research in the Real World”, this resource emphasizes experiential learning through ethical, place-based inquiry.

Students will select a Queens neighborhood undergoing social, economic, or cultural change and use real-world research methods such as diary entries, experience sampling, or oral …

Perceived Risk Of Colorectal Cancer In Oman: Implications For Screening And Prevention, Adhari A. Al Zaabi, Amira Alamri, Thamra Al Ghafri, Ahmed Alhabsi, Munther Alzidi, Abdulmalik Alsarmi, Asmaa Alshidhani

Sultan Qaboos University Medical Journal

Objectives: Colorectal cancer (CRC) remains one of the leading causes of cancer-related deaths worldwide and is the most diagnosed malignancy among men in Oman. Although it has historically affected older populations, a troubling rise in CRC incidence among younger demographics has emerged in recent years. This study assessed perceived CRC risk, beliefs, and awareness among Omani adults and identified sociodemographic predictors to inform culturally tailored prevention strategies. Methods: A national cross-sectional survey of 1,060 adults aged ≥18 years was conducted across Oman between March and August 2023 using a validated questionnaire adapted from the Health Information National Trends Survey (HINTS). …

Staff Education On The Timeliness Of Administration Of Insulin For The Hospitalized Diabetic Patient, Precious C. Abidoye

Walden Dissertations and Doctoral Studies

The problem addressed in this DNP project was the necessity for a nursing staff education program (SEP) focused on the prompt administration of insulin and order management as well as the evaluation of the hospital policy regarding diabetes mellitus in nonpregnant adult patients concerning hypoglycemia/hyperglycemia. Timely administration of insulin in the hospital is essential to maintain blood glucose levels within a permissible range, which greatly reduces the chances of encountering complications related to diabetes. The project questions were: Will there be an alteration in the nursing team members’ understanding of the promptness of insulin administration and the associated policy from …

Staff Education On Understanding Nurse Burnout, Kathlyn Tracy Mcglynn

Walden Dissertations and Doctoral Studies

Summary This Doctor of Nursing Practice (DNP) project was a staff education program on nurse burnout, which remains a pressing issue in healthcare. Burnout is marked by emotional exhaustion, depersonalization, and a diminished sense of personal achievement. Addressing burnout within the nursing profession is important because burnout leads to job dissatisfaction, absenteeism, and turnover. The project was guided by two practice-focused questions: Will there be a change in knowledge from pre- to posttest after participating in an educational program on nurse burnout? Will the objectives of the educational program be met relative to the curriculum presented? Therefore, the purpose of …

Experiences Of Baccalaureate Prepared Nurses On Their Transition To Novice Faculty Members, Theresa Jade Lombardo

Walden Dissertations and Doctoral Studies

The shortage of qualified nursing faculty in Canada threatens the ability to educate sufficient numbers of nurses to meet healthcare demands. Despite this, limited research explores how baccalaureate-prepared nurses experience the transition into nursing faculty roles. The purpose of this qualitative study, guided by Schoening’s nurse educator transition model, was to explore the experiences of baccalaureate prepared nurses on the transition to novice nurse faculty members teaching in 2-year diploma prepared nursing programs in Northwestern Ontario. Five semi-structured interviews were conducted with baccalaureate-prepared novice nursing faculty members, analyzed, and transcribed using Zoom. Data were coded and analyzed using Saldana’s first …