Medicine and Health Sciences Commons^™

Priority Symptoms, Causes, And Self-Management Strategies Reported By Ayas With Cancer, Lauri Linder, Kristin Stegenga, Jeanne Erickson, Suzanne Ameringer, Amy Rose Newman, Yin-Shun Chiu, Catherine Fiona Macpherson

College of Nursing Faculty Research and Publications

Context

Cancer and symptom experiences of adolescents and young adults (AYAs) with cancer can be highly variable, creating challenges for clinicians and researchers who seek to optimize AYAs' health outcomes. Understanding the heuristics AYAs use to designate priority symptoms can provide insight into the meaning they assign to their symptoms and self-management behaviors.

Objectives

This study described the frequency and characteristics of priority symptoms. It qualitatively explored reasons for a symptom's designation as a priority symptom, perceived causes of priority symptoms, and strategies AYAs use to manage priority symptoms.

Methods

Participants in this single-group, longitudinal study reported symptoms using a …

Hypotrichosis With Juvenile Macular Dystrophy: Combination Of Whole-Genome Sequencing And Genome-Wide Homozygosity Mapping Identifies A Large Deletion In Cdh3 Initially Undetected By Whole-Exome Sequencing-A Lesson From Next-Generation Sequencing., Amir Hossein Saeidian, Hassan Vahidnezhad, Leila Youssefian, Soheila Sotudeh, Meisam Sargazi, Sirous Zeinali, Jouni Uitto

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND: Hypotrichosis with juvenile macular dystrophy (HJMD) is an autosomal recessive disorder characterized by abnormal growth of scalp hair and juvenile macular degeneration leading to blindness. We have explored the genetic basis of HJMD in a large consanguineous family with 12 affected patients, 1-76 years of age, with characteristic phenotypes.

METHODS: We first applied genome-wide homozygosity mapping to 10 affected individuals for linkage analysis to identify the genomic region of the defective gene. All affected individuals shared a 7.2 Mb region of homozygosity on chromosome 16q21-22.3, which harbored 298 genes, including CDH3, previously associated with HJMD. However, whole-exome sequencing (WES) …

Evaluation Of A Maternal, Neonatal And Child Health Intervention Package In A Rural District Of Pakistan: A Quasi-Experimental Study, Atif Habib, Kirsten I. Black, Camille Raynes Greenow, Mushtaq Mirani, Sajid Muhammad, Fariha Shaheen, Monika Christofori Khadka, Annette Vondeling, Shabina Ariff, Sajid Bashir Soofi

Department of Paediatrics and Child Health

Background: Pakistan is among the countries which have the highest maternal, neonatal and child mortality rates. Immediate efforts are required to enable Pakistan to achieve the health related sustainable development goals. The continuum of care interventions can substantially reduce the mortality burden, however local evidence to implement them is lacking in Pakistan. We implemented the maternal, neonatal and child health intervention package comprised of health facility strengthening, capacity building, continuum of care interventions and community mobilization and evaluated its effectiveness on maternal, neonatal and child health care practices and neonatal mortality.
Methods: The intervention package was delivered through existing public …

Rethinking Community Based Strategies To Tackle Health Inequities In South Asia, Zulfiqar Ahmed Bhutta, Abhay Bang, Kaosar Afsana, Bishal Gyawali, Mohammed Shafiq Mirzazada, Renuka Jayatissa

Department of Paediatrics and Child Health

No abstract provided.

Hypervirulent Klebsiella Pneumoniae Bloodstream Isolates In The United Arab Emirates, Shaikha Awad Mohammed Al Kaabi

Theses

As the presence of hypervirulent Klebsiella pneumoniae (hvKP) has not been studied in the United Arab Emirates (UAE), the aim was to determine its rate among bloodstream isolates collected in a tertiary care hospital during two years. K. pneumoniae blood isolates of 125 individual patients from Tawam Hospital, Al Ain in 2014-2015 were investigated. Clinical data on patients’ demographics and underlying medical conditions were collected. Speciation was carried out by VITEK 2, antimicrobial susceptibility was determined by disc diffusion, and for colistin by microdilution. Hypermucoviscosity was assessed by string test. Genetic markers of hypervirulence (iucA, rmpA, rmpA2), …

Estimation Of Infectious Intestinal Disease Burden And Description Of The Infectious Disease Surveillance System In Ras Al Khaimah, United Arab Emirates, Fatema Hamdan Saif Al Alkeem Al Zaabi

Dissertations

Introduction: Infectious disease (ID) is an ongoing problem worldwide. In order to manage this problem, it is important to have an integrated and effective surveillance system that can be used to estimate the burden of ID. There is a scarcity of studies published on the prevalence of IDs in the United Arab Emirates (UAE), both in hospital settings and in the community. Infectious Intestinal Disease (IIDs) have been one of the most commonest IDs that have been studied in the community around the world, there are no studies on the prevalence of IIDs in Ras Al Khaimah (RAK). Furthermore, while …

Characterizing And Predicting Repeat Food Consumption Behavior For Just-In-Time Interventions, Yue Liu, Helena Huey Chong Lee, Palakorn Achananuparp, Ee-Peng Lim, Tzu-Ling Cheng, Shou-De Lin

Research Collection School Of Computing and Information Systems

Human beings are creatures of habit. In their daily life, people tend to repeatedly consume similar types of food items over several days and occasionally switch to consuming different types of items when the consumptions become overly monotonous. However, the novel and repeat consumption behaviors have not been studied in food recommendation research. More importantly, the ability to predict daily eating habits of individuals is crucial to improve the effectiveness of food recommender systems in facilitating healthy lifestyle change. In this study, we analyze the patterns of repeat food consumptions using large-scale consumption data from a popular online fitness community …

Smrtfridge: Iot-Based, User Interaction-Driven Food Item & Quantity Sensing, Amit Sharma, Archan Misra, Vengateswaran Subramaniam, Youngki Lee

Research Collection School Of Computing and Information Systems

We present SmrtFridge, a consumer-grade smart fridge prototype that demonstrates two key capabilities: (a) identify the individual food items that users place in or remove from a fridge, and (b) estimate the residual quantity of food items inside a refrigerated container (opaque or transparent). Notably, both of these inferences are performed unobtrusively, without requiring any explicit user action or tagging of food objects. To achieve these capabilities, SmrtFridge uses a novel interaction-driven, multi-modal sensing pipeline, where Infrared (IR) and RGB video sensing, triggered whenever a user interacts naturally with the fridge, is used to extract a foreground visual image of …

Estimating Glycemic Impact Of Cooking Recipes Via Online Crowdsourcing And Machine Learning, Helena Lee, Palakorn Achananuparp, Yue Liu, Ee-Peng Lim, Lav R. Varshney

Research Collection School Of Computing and Information Systems

Consumption of diets with low glycemic impact is highly recommended for diabetics and pre-diabetics as it helps maintain their blood glucose levels. However, laboratory analysis of dietary glycemic potency is time-consuming and expensive. In this paper, we explore a data-driven approach utilizing online crowdsourcing and machine learning to estimate the glycemic impact of cooking recipes. We show that a commonly used healthiness metric may not always be effective in determining recipes suitable for diabetics, thus emphasizing the importance of the glycemic-impact estimation task. Our best classification model, trained on nutritional and crowdsourced data obtained from Amazon Mechanical Turk (AMT), can …

Vitamon: Measuring Heart Rate Variability Using Smartphone Front Camera, Sinh Huynh, Rajesh Krishna Balan, Jeonggil Ko, Youngki Lee

Research Collection School Of Computing and Information Systems

We present VitaMon, a mobile sensing system that can measure the inter-heartbeat interval (IBI) from the facial video captured by a commodity smartphone's front camera. The continuous IBI measurement is used to compute heart rate variability (HRV), one of the most important markers of the autonomic nervous system (ANS) regulation. The underlying idea of VitaMon is that video recording of human face contains multiple cardiovascular pulse signals with different phase shift. Our measurement on 10 participants shows the significant time delay (36.79 ms) between the pulse signals measured at the jaw region and forehead region. VitaMon leverages deep neural network …

The Nurse As The Facilitator Of Patients' Narration: An Educational Intervention, Petra Stockman

Electronic Theses and Dissertations

More than one million resident patients live and receive care at certified long-term facilities in the United States, many of whom suffer from depressive symptoms and anxiety. Prior research recommended storytelling as a vibrant nursing intervention to assist long-term care residents in overcoming challenges and emotional pain. However, nurses frequently lack knowledge of successful planning and implementation of narrative reminiscence. This scholarly project was designed to increase nursing competence and confidence in using storytelling as a clinical tool to improve mental health in long-term care, using a quasi-experimental, nonrandomized pretest, intervention, and posttest study design. A convenience sample of 10 …

Chronic Kidney Disease: The Need To Increase Nurse Practitioner Awareness, Juan Hernandez

Electronic Theses and Dissertations

Abstract

Chronic kidney disease (CKD) has become a major issue in the United States. Individuals with chronic disease such as diabetes, cardiovascular disease, or hyperlipidemia are at higher risk of CKD. Risk factors include family history, age, obesity, and smoking. Kidney function decreases with age and other related conditions. It is critical to increase awareness, education, and prevention of CKD to advanced practice nurses. Nurse practitioners encounter and have the responsibility to be able to identify and manage patients in their primary practice. To address this issue, a sample of nurse practitioners in a local community health center was surveyed …

Exploration Of Mindfulness Among Ethnic Minority Undergraduate Nursing Students, Amber Young-Brice, Kristina Dreifuerst

College of Nursing Faculty Research and Publications

Background. Meeting projected needs for ethnically diverse nurses depends on a strong pipeline of diverse students within nursing programs. Colleges assume students readily navigate the university; however, this may not be the reality especially among ethnic minority students.

Purpose. The purpose was to explore the concept of mindfulness among ethnic minority nursing students. Exploring mindfulness, and a lack thereof, may provide strategies for overcoming challenges ethnic minority students experience in prelicensure nursing programs.

Methods. A qualitative study using thematic analysis of semistructured in-depth interviews was conducted with 20 ethnic minority undergraduate nursing students.

Results. Themes that emerged reveal positive associations …

Time To Move: Shifting The Icu Paradigm To Improve Outcomes For Survivors Of Critical Illness, Jill L. Guttormson, Natalie S. Mcandrew

College of Nursing Faculty Research and Publications

No abstract provided.

Gemcitabine Combination Nano Therapies For Pancreatic Cancer, Kamalika Samanta, Saini Setua, Sonam Kumari, Meena Jaggi, Murali Yallapu, Subhash C. Chauhan

School of Medicine Publications

Pancreatic cancer is one of the deadliest causes of cancer-related death in the United States, with a 5-year overall survival rate of 6 to 8%. These statistics suggest that immediate medical attention is needed. Gemcitabine (GEM) is the gold standard first-line single chemotherapy agent for pancreatic cancer but, after a few months, cells develop chemoresistance. Multiple clinical and experimental investigations have demonstrated that a combination or co-administration of other drugs as chemotherapies with GEM lead to superior therapeutic benefits. However, such combination therapies often induce severe systemic toxicities. Thus, developing strategies to deliver a combination of chemotherapeutic agents more securely …

Fine Mapping And Identification Of Serum Urate Loci In American Indians: The Strong Heart Family Study, Geetha Chittoor, Karin Haack, Poojitha Balakrishnan, Christopher Bizon, Sandra Laston, Lyle G. Best, Jean W. Maccluer, Kari E. North, Jason G. Umans

School of Medicine Publications

While studies have reported genetic loci affecting serum urate (SU) concentrations, few studies have been conducted in minority populations. Our objective for this study was to identify genetic loci regulating SU in a multigenerational family-based cohort of American Indians, the Strong Heart Family Study (SHFS). We genotyped 162,718 single nucleotide polymorphisms (SNPs) in 2000 SHFS participants using an Illumina MetaboChip array. A genome-wide association analysis of SU was conducted using measured genotype analysis approach accounting for kinships in SOLAR, and meta-analysis in METAL. Our results showed strong association of SU with rs4481233, rs9998811, rs7696092 and rs13145758 (minor allele frequency (MAF) …

Accessible Design In Rural Health Care: Usability Profile Of Outpatient Health Care Facilities In Rural West Virginia, Jordan Elliott Miller, Chris Haddox

Marshall Journal of Medicine

The purpose of this research is to better understand the physical and environmental features of outpatient healthcare facilities that act as barriers to healthcare access in rural West Virginia and factors that contribute to non-compliance with the ADA. The research aims to explore the prevalence of barriers in rural West Virginia health facilities and the relationship between building characteristics (like year of construction and original purpose) and accessibility. The researcher evaluated ten rural outpatient member-sites of the West Virginia Practice-Based Research Network using the Outpatient Health Care Usability Profile to measure essential features for a facility to be considered ‘usable’. …

Statistical Methods Useful In Clinical Simulation And Medical Education Scholarship, Zuber D. Mulla, J. Hector Aranda, Donovan Rojas, Sanja Kupesic Plavsic

Marshall Journal of Medicine

The objective of this paper is to introduce selected statistical and epidemiologic topics that are of interest to interdisciplinary teams of healthcare quality professionals, educators, technical staff, and researchers who participate in clinical simulation scholarship. Four research vignettes in the setting of a hypothetical clinical simulation training workshop are presented. The first vignette illustrates the utility of exact logistic regression when analyzing a small dataset. The second underscores the importance of using an appropriate method to account for the repeated measurement of an outcome. The third illustrates the use of the intraclass correlation coefficient to measure inter-rater reliability. The final …

Cavernous Sinus Thrombosis Complicated By Carotid Artery Occlusion: A Case Report, Faisal Taleb, Seraj S. Ajaj, Abdussalam Abograra, Ali Eldeeb

Marshall Journal of Medicine

Cavernous sinus thrombosis (CST) is a fatal phenomenon that requires clinical suspicion and emergent imaging for correct diagnosis. . However, only a few authors reported severe involvement of the internal carotid artery (ICA). Here we report an 11 year old girl diagnosed with Cavernous sinus thrombosis complicated by left internal carotid artery occlusion.

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Diabetic Muscle Infarction: A Rare End-Organ Vascular Complication Of Diabetes, Callie Seaman, Michael Amos, Adam M. Franks, Asher Sexton, Kimberly Mcclelland, Erika M. Harris

Marshall Journal of Medicine

Diabetic muscle infarction (DMI) is a rare microvascular complication of spontaneous ischemic necrosis of skeletal muscle in patients with poorly controlled diabetes. We herein describe the case of a 26-year-old woman with a history of type I diabetes and accompanying diabetic microvascular complications of neuropathy, nephropathy and retinopathy, who presented with sudden onset of swelling and sharp pain in her bilateral thighs. T2-weighted MRI imaging revealed subcutaneous edema and sub-fascial, hyper-intense enhancement of proximal thigh musculature. DMI has a relatively non-specific clinical presentation; therefore, physician awareness is key for early diagnosis, as aggressive management has been associated with poor patient …

Artificial Intelligence And The Challenge For Rural Medicine, James Denvir

Marshall Journal of Medicine

Recent advances in artificial intelligence, machine learning, and deep learning are beginning to have an impact on everyday experiences, from natural language processing used in automated telephone call centers to semi-autonomous vehicles. These techniques have also been applied to medical care. In this editorial we discuss applications of AI to medicine and argue for a proactive approach to include rural medicine in this paradigm shift.

Pigmentary And Other Dermatologic Manifestations Of Minocycline: A Reminder Of Adverse Effects, Kayla Rodriguez, Courtney Wellman, Adam M. Franks, Kimberly Mcclelland, Tammy Bannister

Marshall Journal of Medicine

The applications of the tetracycline class of antibiotics extends beyond their antimicrobial activity to anti-inflammatory, immunosuppressive and neuroprotective applications making it a commonly used class of medication. Minocycline, a second generation tetracycline, has inherent characteristics that improve absorption and distribution. These benefits promote even more wide spread use. This familiarity of usage breeds prescriptive complacency toward the dermatologic complications including hyperpigmentation. The following case explores these adverse manifestations of Minocycline use.

Acute Diagnosis Of Wilson’S Disease In A Teenage Patient, Sarah Irvin, Ryan Mccarthy

Marshall Journal of Medicine

Wilson’s Disease, a rare autosomal recessive genetic disease, is caused by a mutation in the ATP7B enzyme gene. Without this enzyme, copper builds up in the brain, liver, and cornea causing a multitude of symptoms. It is important to consider Wilson’s disease because the prognosis is dependent on timely diagnosis. This is an interesting case of a 19-year-old male who presented with suicidal thoughts and rapid weight loss. After many months and an extensive work-up, Wilson’s Disease was diagnosed. Due to his rapid decline, he was transferred to a larger university healthcare center where he is currently enrolled in clinical …

Is Napping A Good Thing?, Sammar Atassi

Marshall Journal of Medicine

This article aims to explore new findings in research in the relationship between sleep disorders and dementia. The new research questions the glymphatic system's role in clearing the toxic proteins from the brain during sleep.

Case Reports: Add Value Beyond The Impact Factor, Darshana T. Shah

Marshall Journal of Medicine

No abstract provided.

Evaluating Feline Release Criteria Following Iodine-131 Therapy For Hyperthyroidism, Anthony Davila

LSU Master's Theses

Hyperthyroidism is a very common endocrine disorder in both humans and cats. Radioactive iodine ablation therapy is considered the gold standard; however, the patient becomes a radiation source and poses a potential radiological risk to others. The regulations governing when the patient can be released differ between human medicine and veterinary medicine. A human patient can receive up to 33 mCi of I-131 and be discharged the same day; yet a feline patient can receive a dose as low as 2 mCi and require multiple days of hospitalization. This discrepancy has not been satisfactorily addressed; and overly restrictive release criteria …

Unlocking Data To Deliver Infant Mortality Solutions, Kylie Veleta

Innovation and SimLab

No abstract provided.

Deepcon-Pre: Improved Protein Contact Map Prediction Using Inverse Covariance And Deep Residual Networks, Nachammai Palaniappan

Theses

As with most domains where machine learning methods are applied, correct feature engineering is critical when developing deep learning algorithms for solving the protein folding problem. Unlike the domains such as computer vision and natural language processing, feature engineering is not rigorously studied towards solving the protein folding problem. A recent research has highlighted that input features known as precision matrix are most informative for predicting inter-residue contact map, the key for building three-dimensional models. In this work, we study the significance of the precision matrix feature when very deep residual networks are trained. Using a standard dataset of 3456 …

Split Selectable Markers., Nathaniel L. Jillette, Menghan Du, Jacqueline Jufen Zhu, Peter Cardoz, Albert W Cheng

Faculty Research 2019

Selectable markers are widely used in transgenesis and genome editing for selecting engineered cells with a desired genotype but the variety of markers is limited. Here we present split selectable markers that each allow for selection of multiple "unlinked" transgenes in the context of lentivirus-mediated transgenesis as well as CRISPR-Cas-mediated knock-ins. Split marker gene segments fused to protein splicing elements called "inteins" can be separately co-segregated with different transgenic vectors, and rejoin via protein trans-splicing to reconstitute a full-length marker protein in host cells receiving all intended vectors. Using a lentiviral system, we create and validate 2-split Hygromycin, Puromycin, Neomycin …

Relationship Between Smoking Habit And Sperm Parameters Among Patients Attending An Infertility Clinic, Rehana Rehman, Nida Zahid, Sofia Amjad, Mukhtiar Baig, Zohair Jamil Gazzaz

Department of Biological & Biomedical Sciences

Background: This study aimed to estimate stress markers, oxidative stress (OS), reproductive hormones and sperm parameters in male smokers and non-smokers and observe the impact of oxidative stress markers and smoking on sperm count, motility and morphology in a selected population of Karachi, Pakistan.
Methods: This cross-sectional study was conducted from July 2017 to July 2018 at Aga Khan University (AKU), in Karachi, Pakistan. The subjects were recruited from the Sindh Institute of Reproductive Medicine (SIRM), Karachi based on defined inclusion criteria. The subjects were categorized into fertile and infertile based on cut off values of sperm parameters as recommended …