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Articles 161131 - 161160 of 325454
Full-Text Articles in Medicine and Health Sciences
Role Of Pomegranate Peel On Ameliorated Hyperglycemia And Hypercholesterolemia In Experimental Rats, Magda Ramzy
Role Of Pomegranate Peel On Ameliorated Hyperglycemia And Hypercholesterolemia In Experimental Rats, Magda Ramzy
Journal of Medicine in Scientific Research
Introduction Pomegranate peels (Punica granatum) (contain fiber and antioxidants, which are beneficial to our health. This study aimed to investigate the effects of different concentrations of pomegranate peels on blood glucose, lipid profiles, and some physiological parameters, such as liver and kidney functions, in rats having diabetes and hypercholesterolemia. Methods Rats were divided into three main groups: the first main group was the negative control, the second main group was diabetic rats, and the third main group was hypercholesterolemic rats. Second and third main groups were divided into four subgroups (six rats/group) and fed with different diet levels …
Computerized Dynamic Posturography In School-Aged Children With Sensorineural Hearing Loss, Hanaa Fadel, Hoda Abu-Moussa Mina, Naema M. Ismail, Shereen Emad El Dein Abdel Moneim
Computerized Dynamic Posturography In School-Aged Children With Sensorineural Hearing Loss, Hanaa Fadel, Hoda Abu-Moussa Mina, Naema M. Ismail, Shereen Emad El Dein Abdel Moneim
Journal of Medicine in Scientific Research
Background According to embryological and anatomical connection between the cochlea and vestibular end-organs, children with sensorineural hearing loss (SNHL) may exhibit abnormalities of vestibular and balance function. Documentation of vestibular dysfunction in children with SNHL has a long and rich history indicating that 20–70% of children with SNHL demonstrate an element of vestibular end-organ dysfunction. Vestibular dysfunction was proved to correlate with severity of cochlear loss in many research works. Aim of the work To assess normative data of sensory organization test (SOT) and head shaking (HS) test according to age, weight, and height of children in control group and …
Comparable Study Between Organic And Nonorganic Vegetables In Their Contents Of Some Nutritive Components, Hamdy A. El-Bassel, Hany H. El-Gazzar
Comparable Study Between Organic And Nonorganic Vegetables In Their Contents Of Some Nutritive Components, Hamdy A. El-Bassel, Hany H. El-Gazzar
Journal of Medicine in Scientific Research
Background There is no doubt that vegetables play an essential role in human growth as they provide the human body the necessary needs of vitamins and minerals. Several analytical methods have been set up and improved to determine the quantity of vitamins and minerals in different fruits and vegetables. The purpose of this study is to evaluate the quantities of vitamins and minerals in organic and nonorganic vegetables in Egyptian. The results showed that organic tomatoes, eggplant, lettuce, squash, carrots, and cabbage had significantly higher content of vitamin C, vitamin E, β-carotene, phosphorus, and calcium. However, nonorganic vegetables showed significantly …
Haptoglobin Genotyping And Risk Of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage, Ahmed M. Ateya, Ahmed A. El-Bassiouny, Islam El-Garwany, Khaled Gobbah, Mahmoud H. Ibrahim, Nagia A. Fahmy, Sobhy H. El-Nabi
Haptoglobin Genotyping And Risk Of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage, Ahmed M. Ateya, Ahmed A. El-Bassiouny, Islam El-Garwany, Khaled Gobbah, Mahmoud H. Ibrahim, Nagia A. Fahmy, Sobhy H. El-Nabi
Journal of Medicine in Scientific Research
Background Aneurysmal subarach noid hemorrhage (aSAH) represents roughly 6–8% of all stroke types. Almost 70% of patients develop angiographic vasospasm, and 30% of them will have delayed cerebral ischemia (DCI). An 'omic signature' could combine genetic, proteomic, and metabolomic phenotypes into an accurate predictive model. Haptoglobin (Hp) genotypes could be used to stratify risk of resulting cerebral vasospasm (CV) and DCI, to give prognostic data dependent on distributed result probabilities, and to develop novel medications dependent on individual pathophysiological models. Objective This research intends to investigate the clinical and radiological factors as indicators for risk of development of CV after …
The Role Of Vitamin D Therapy In Patients With Fibromyalgia And Its Effect On Quality Of Life, Abeer H. Ismaiel, Aliaa El-Hady, Amal A. Mohsen, Mohamed A. Safy
The Role Of Vitamin D Therapy In Patients With Fibromyalgia And Its Effect On Quality Of Life, Abeer H. Ismaiel, Aliaa El-Hady, Amal A. Mohsen, Mohamed A. Safy
Journal of Medicine in Scientific Research
Objective To investigate the level of vitamin D and the effect of its therapy on quality of life in patients with fibromyalgia who had vitamin D deficiency. Patients and methods Sixty patients presenting with fibromyalgia and 30 healthy controls were studied. Patients were grouped as deficient (<20 ng/ml), inadequate (20–30 ng/ml), and sufficient (>30 ng/ml) according to the levels of vitamin D. Vitamin D replacement was performed for patients with deficiencies and inadequacies and they were assessed before and after vitamin D therapy using the following scales: visual analog scale, fibromyalgia impact questionnaire, short form-36, Arizona sexual life questionnaire, and Beck depression scale and correlation were …20>
Effect Of Liver Cirrhosis On Patient Outcomes From Open Heart Surgery, Ahmed A. Faragalla, Hossam B. Kashlan, Wael A. Elhakeem
Effect Of Liver Cirrhosis On Patient Outcomes From Open Heart Surgery, Ahmed A. Faragalla, Hossam B. Kashlan, Wael A. Elhakeem
Journal of Medicine in Scientific Research
Background We designed this prospective controlled study to evaluate the early postoperative outcomes in patients with liver cirrhosis (LC) after open heart surgery (OHS). Patients and methods Between May 2011 and February 2017, 120 patients with elective OHS were included and categorized into a control group (50%) and patients with LC (50%), who were further subdivided according to Child–Turcotte–Pugh (CTP) score into group CTP A (49 patients) and CTP B (11 patients). All preoperative demographic and clinical data in addition to operative and postoperative data were evaluated. Patients with CTP (class C) were excluded. Results Overall, 48 (40%) patients experienced …
Falls Prevention Among Older Adults At A Nursing Home In A Northern Suburban Of Perth In Western Australia, Horatius Musembi, Deborah Sundin
Falls Prevention Among Older Adults At A Nursing Home In A Northern Suburban Of Perth In Western Australia, Horatius Musembi, Deborah Sundin
School of Nursing & Midwifery, East Africa
The objective was to identify factors leading to falls and determine the role of nurses and carers play in falls prevention. A retrospective audit of the performance of nurses and carers regarding falls prevention among older adults was used. Residents who had a fall during July 2015 (n=25) were identified using purposeful sampling. Data for this study were collected from the files of these residents. Data analysis was done by using the Fisher exact test which was appropriate for the collected data. Residents aged 85-89 years had the most falls (32%); however, one resident who fell five times in the …
Week Of November 25, 2019, New York Medical College
Week Of November 25, 2019, New York Medical College
InTouch
- Accessibility Awareness and Education Lecture Focuses on Diabetes for National Diabetes Awareness Month
- School of Medicine Alumni Association Hosts Annual Reunion
- StuHE Hosts Career Mentor Session
The Early "Unnatural" History Following Surgical Repair Of Ventricular Septal Defects., Sathish M. Chikkabyrappa, Justin T. Tretter, Arpan R. Doshi, Sujatha Buddhe, Puneet Bhatla, Achi Ludomirsky
The Early "Unnatural" History Following Surgical Repair Of Ventricular Septal Defects., Sathish M. Chikkabyrappa, Justin T. Tretter, Arpan R. Doshi, Sujatha Buddhe, Puneet Bhatla, Achi Ludomirsky
Manuscripts, Articles, Book Chapters and Other Papers
Introduction: Surgical outcomes for simple ventricular septal defects (VSD) have been excellent in the past three decades. For this project, the timing of resolution of left-sided dilation and mitral regurgitation (MR) following VSD repair was assessed.
Methods: Echocardiographic data surrounding surgery of 42 consecutive children who underwent surgical patch repair of a VSD were reviewed. The echocardiograms were reviewed up to a mean of 12 months post-operatively (range 9 - 14 months). Quantitative data indexed to body surface area including left atrial (LA) volume, mitral valve annulus diameter, and left ventricular end-diastolic dimension (LVEDD) was analyzed.
Results: The majority of …
Cancer-Related Risk Behaviors And Screening Intention Among Recreational Sport Athletes, Aldenise P. Ewing
Cancer-Related Risk Behaviors And Screening Intention Among Recreational Sport Athletes, Aldenise P. Ewing
USF Tampa Graduate Theses and Dissertations
The recreational sports arena provides a venue for young adults to increase physical activity and engage in a socially supportive environment. These are both important ways to decrease the risk for chronic diseases. It is assumed that physically active individuals lead healthier lifestyles and are more attuned to their long-term health needs. Recreational sport athletes also engage in risks for adverse cancer outcomes through increased sun exposure, intake of unhealthy diets, and recreational tobacco and alcohol use. It was of interest to assess cancer-related risk factors, cancer knowledge, and theory of planned behavior constructs in this group.
This study involved …
The Epidemiological Burden Of Obesity In Childhood: A Worldwide Epidemic Requiring Urgent Action, Mariachiara Di Cesare, Maroje Sorić, Pascal Bovet, J Jaime Miranda, Zulfiqar Ahmed Bhutta, Gretchen A. Stevens, Avula Laxmaiah, Andre-Pascal Kengne, James Bentham
The Epidemiological Burden Of Obesity In Childhood: A Worldwide Epidemic Requiring Urgent Action, Mariachiara Di Cesare, Maroje Sorić, Pascal Bovet, J Jaime Miranda, Zulfiqar Ahmed Bhutta, Gretchen A. Stevens, Avula Laxmaiah, Andre-Pascal Kengne, James Bentham
Department of Paediatrics and Child Health
Background: In recent decades, the prevalence of obesity in children has increased dramatically. This worldwide epidemic has important consequences, including psychiatric, psychological and psychosocial disorders in childhood and increased risk of developing non-communicable diseases (NCDs) later in life. Treatment of obesity is difficult and children with excess weight are likely to become adults with obesity. These trends have led member states of the World Health Organization (WHO) to endorse a target of no increase in obesity in childhood by 2025.
Main body: Estimates of overweight in children aged under 5 years are available jointly from the United Nations Children's Fund …
Determinants Of Linear Growth Faltering Among Children With Moderate-To-Severe Diarrhea In The Global Enteric Multicenter Study, Rebecca L. Brander, Patricia B. Pavlinac, Judd L. Walson, Grace C. John-Stewart, Marcia R. Weaver, Abu S. G Faruque, Anita K. M. Zaidi, Dipika Sur, Samba O. Sow, M Jahangir Hossain
Determinants Of Linear Growth Faltering Among Children With Moderate-To-Severe Diarrhea In The Global Enteric Multicenter Study, Rebecca L. Brander, Patricia B. Pavlinac, Judd L. Walson, Grace C. John-Stewart, Marcia R. Weaver, Abu S. G Faruque, Anita K. M. Zaidi, Dipika Sur, Samba O. Sow, M Jahangir Hossain
Department of Paediatrics and Child Health
Background: Moderate-to-severe diarrhea (MSD) in the first 2 years of life can impair linear growth. We sought to determine risk factors for linear growth faltering and to build a clinical prediction tool to identify children most likely to experience growth faltering following an episode of MSD.
Methods: Using data from the Global Enteric Multicenter Study of children 0-23 months old presenting with MSD in Africa and Asia, we performed log-binomial regression to determine clinical and sociodemographic factors associated with severe linear growth faltering (loss of ≥ 0.5 length-for-age z-score [LAZ]). Linear regression was used to estimate associations with ΔLAZ. A …
Medical School Watercooler Newsletter - November 24, 2019, Lindsey Lyle
Medical School Watercooler Newsletter - November 24, 2019, Lindsey Lyle
Watercooler Newsletter
This is the November 24, 2019 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.
Contents Include:
Simmons completes surgery leadership program at Harvard
Brooks to discuss flap surgery at grand rounds
Neurology resident to present on motor neuron disease at grand rounds
Culpepper to address chronic kidney disease at medicine grand rounds
Boudreaux named associate dean for graduate medical education
Forests And Mental Health In South Africa: Panel Data Evidence, Dambala Gelo
Forests And Mental Health In South Africa: Panel Data Evidence, Dambala Gelo
Forest Collaborative Research
Slides from a presentation that examines the linkages between the green environment (urban forests, green open urban space) and mental health in South Africa. The author used representative panel data from the National Income Dynamics Survey, including the Center for Epidemiological Studies Short Depression Scale, to uncover these links.
Finding Latent Groups In Observed Data: A Primer On Latent Profile Analysis In Mplus For Applied Researchers, Sarah L. Ferguson, E. Whitney G. Moore, Darrell M. Hull
Finding Latent Groups In Observed Data: A Primer On Latent Profile Analysis In Mplus For Applied Researchers, Sarah L. Ferguson, E. Whitney G. Moore, Darrell M. Hull
Kinesiology, Health and Sport Studies
The present guide provides a practical guide to conducting latent profile analysis (LPA) in the Mplus software system. This guide is intended for researchers familiar with some latent variable modeling but not LPA specifically. A general procedure for conducting LPA is provided in six steps: (a) data inspection, (b) iterative evaluation of models, (c) model fit and interpretability, (d) investigation of patterns of profiles in a retained model, (e) covariate analysis, and (f) presentation of results. A worked example is provided with syntax and results to exemplify the steps.
My Healthcare Administration Experience At Lifecare Alliance, Ayat Al Jbour
My Healthcare Administration Experience At Lifecare Alliance, Ayat Al Jbour
Masters Theses/Capstone Projects
My practicum site was LifeCare Alliance, "Nourishing the Human Spirit. It is a not-for-profit organization that provides a comprehensive array of health and nutrition service to residents of Central Ohio.
Northwest Immigrant Rights Project, Jorge Baron, Maria Kolby-Wolfe, Kristen Smith Dayley, Twila Bird, Tsos
Northwest Immigrant Rights Project, Jorge Baron, Maria Kolby-Wolfe, Kristen Smith Dayley, Twila Bird, Tsos
TSOS Interview Gallery
The Northwest Immigrant Rights Program has been around for 35 years, started in 1984 specifically to help Central American refugees during the mid-1980s, when they were fleeing civil wars. A pro-bono group of attorneys performing "direct legal representation", helping low income community members who are navigating different aspects of the immigration system. NWIRP also engages in "systemic advocacy" which attempts to change systems and policies revolving around asylum and immigration rights.
A Quality Improvement Study On Missed Appointment Management In Primary Care, Aunye' Dina Amos
A Quality Improvement Study On Missed Appointment Management In Primary Care, Aunye' Dina Amos
Dissertations
Abstract
Problem: Patients who miss appointments have poorer health outcomes and increase costs for medical care. The purpose of this quality improvement study was to evaluate the effects of missed appointments on patients’ outcomes for diabetes mellitus, and resulting financial losses to a private primary care practice.
Method: A quality improvement initiative with a retrospective review of patients over a six-month period in 2018 (before) and 2019 (after a missed appointment fee was implemented). All adult patients, aged 18-92 years, were included. For those with diabetes, a HbA1c for each patient who kept or missed their appointment was recorded.
Results: …
Trends And Disparities In Self-Reported And Measured Osteoporosis Among Us Adults, 2007-2014., Qing Wu, Yingke Xu, Ge Lin
Trends And Disparities In Self-Reported And Measured Osteoporosis Among Us Adults, 2007-2014., Qing Wu, Yingke Xu, Ge Lin
Environmental & Global Health Faculty Research
(1) Background: Studies examining osteoporosis trends among US adults by different socioeconomic status (SES) are limited. The prevalence of self-reported osteoporosis in the US is rarely reported. (2) Methods: Data from the National Health and Nutritional Examination Survey (NHANES) between 2007–2008 and 2013–2014 cycles were analyzed. Age-adjusted prevalence of self-reported and that of measured osteoporosis were calculated overall and by sex, race/ethnicity, education attainment, and SES. (3) Results: The prevalence of self-reported osteoporosis was higher than that of measured osteoporosis in all three survey cycles for women, and in 2007–2008 and 2009–2010 for men. Participants with high school/GED or higher …
Trends And Associated Factors Of Use Of Opioid, Heroin, And Cannabis Among Patients For Emergency Department Visits In Nevada: 2009-2017, Pearl C. Kim, Ji Won Yoo, Chris R. Cochran, Seong-Min Park, Sungyoun Chun, Yong-Jae Lee, Jay J. Shen
Trends And Associated Factors Of Use Of Opioid, Heroin, And Cannabis Among Patients For Emergency Department Visits In Nevada: 2009-2017, Pearl C. Kim, Ji Won Yoo, Chris R. Cochran, Seong-Min Park, Sungyoun Chun, Yong-Jae Lee, Jay J. Shen
School of Medicine Faculty Research
To examine trends and contributing factors of opioid, heroin, and cannabis-associated emergency department (ED) visits in Nevada. The 2009 to 2017 Nevada State ED database (n = 7,950,554 ED visits) were used. Use of opioid, heroin, and cannabis, respectively, was identified by the International Classification of Diseases, 9th & 10th Revisions. Three multivariable models, one for each of the 3 dependent variables, were conducted. Independent variables included year, insurance status, race/ethnicity, use of other substance, and mental health conditions. The number of individuals with opioid, heroin, cannabis-associated ED visits increased 3%, 10%, and 23% annually from 2009 to 2015, particularly …
Calcium Pyrophosphate Deposition Disease In The Achilles Tendon, Kai-Yu Ho, Jing Nong Liang
Calcium Pyrophosphate Deposition Disease In The Achilles Tendon, Kai-Yu Ho, Jing Nong Liang
Physical Therapy Faculty Research
The classic sonographic presentation of calcium pyrophosphate dihydrate crystal deposits in the Achilles tendon is reported.
Elevated Glucose Acts Directly On Osteocytes To Increase Sclerostin Expression In Diabetes, Donna M. Pacicca, Tammy Brown, Dara Watkins, Karen Kover, Yun Yan, Matthew Prideaux, Lynda Bonewald
Elevated Glucose Acts Directly On Osteocytes To Increase Sclerostin Expression In Diabetes, Donna M. Pacicca, Tammy Brown, Dara Watkins, Karen Kover, Yun Yan, Matthew Prideaux, Lynda Bonewald
Manuscripts, Articles, Book Chapters and Other Papers
© 2019, The Author(s).
Bone quality in diabetic patients is compromised, leading to weaker bones and increased fracture risk. However, the mechanism by which this occurs in diabetic bone remains to be fully elucidated. We hypothesized that elevated glucose and glucose variation would affect the function of osteocytes, essential regulators of bone homeostasis and quality. To first test this hypothesis, we used the IDG-SW3 osteocyte-like cell line to examine the effects of glucose levels on osteocyte function and viability in vitro. We confirmed our in vitro findings using the in vivo streptozotocin-induced (STZ) diabetic rat model and ex-vivo cultured osteocytes …
You Learn When You Teach: A Narrative Pedagogy For Faculty And Doctoral-Level Student Teaching Assistants, Lauren A. Acosta Ms, Rn, Phd Candidate, Penny M. Overgaard Phd, Msn, Rn, Natalie M. Pool Phd, Rn, Bsn, Susan M. Renz Phd, Dnp, Rn, Gnp-Bc, Janice D. Crist Phd, Rn, Fwan, Faan
You Learn When You Teach: A Narrative Pedagogy For Faculty And Doctoral-Level Student Teaching Assistants, Lauren A. Acosta Ms, Rn, Phd Candidate, Penny M. Overgaard Phd, Msn, Rn, Natalie M. Pool Phd, Rn, Bsn, Susan M. Renz Phd, Dnp, Rn, Gnp-Bc, Janice D. Crist Phd, Rn, Fwan, Faan
The Qualitative Report
The purpose of this study was to understand the meaning of online co-teaching for PhD faculty and teaching assistants (TAs). Narrative pedagogy underpinned the inquiry, which was designed to advance the discourse on mentorship of PhD future faculty. A faculty member and TA authors kept concurrent weekly journals or after-the-fact written reflections. The authors analyzed data as a team using a five-phase interpretive phenomenological analysis process to interpret the meaning of co-teaching for faculty and TAs. Lines of inquiry, central concerns, exemplars, shared meanings, and paradigm cases supported the overall interpretation, “You Learn When You Teach.” Co-mentorship should be a …
How Urban Land Use Contributes To Inequitable Health Outcomes: An Interdisciplinary Review & Analysis, Bliss Storm Croton
How Urban Land Use Contributes To Inequitable Health Outcomes: An Interdisciplinary Review & Analysis, Bliss Storm Croton
University Honors Theses
Using existing literature as a basis for initial review, this paper seeks to explore the relationship between urban land use and socioeconomic status as both pertain to the prevalence of psychological health diagnoses among neighborhood residents. The purpose of this analysis is to investigate the combined literature from multiple areas of research in order to gain a more holistic, up-to-date scope of knowledge regarding how discriminatory neighborhood land use may result in poorer psychological health outcomes for urban populations. By utilizing an interdisciplinary approach, some of the locally relevant, long-term impacts of uneven development and environmental injustice are examined based …
Art Therapy And Dialectical Behavioral Therapy: A Workbook, Jasmine S. Griswold
Art Therapy And Dialectical Behavioral Therapy: A Workbook, Jasmine S. Griswold
University Honors Theses
Looking into the ways in which we treat anxiety and depression in both clinical and casual settings it seemed apparent that there are similar tools being utilized to alleviate the effects, but there didn’t seem to be a cohesion of these tools. With Dialectical Behavioral Therapy (DBT) a mindfulness based approach to therapy and the use of art as a tool to create dialogue in Art Therapy (AT) it seemed appropriate to combine the modalities to create a workbook that could be used on one's own or in conjunction with a therapist.
Male Burmese Pythons Follow Female Scent Trails And Show Sex-Specific Behaviors, Shannon A. Richard, Eric A. Tillman, John S. Humphrey, Michael L. Avery, M. Rockwell Parker
Male Burmese Pythons Follow Female Scent Trails And Show Sex-Specific Behaviors, Shannon A. Richard, Eric A. Tillman, John S. Humphrey, Michael L. Avery, M. Rockwell Parker
United States Department of Agriculture Wildlife Services: Staff Publications
Animals communicate with potential mates using species-specific signals, and pheromones are powerful sexual signals that modify conspecific behavior to facilitate mate location. Among the vertebrates, snakes are especially adept in mate searching via chemical trailing, which is particularly relevant given that many snake species are invasive outside their native ranges. Chemical signals used in mate choice are, thus, potentially valuable tools for management of invasive snake species. The Burmese python (Python bivittatus) is an invasive snake in the Florida Everglades where it is negatively impacting native fauna. In this study, we sought to: (i) determine if males can follow conspecific …
Millennial Perceptions Of Leadership As An Influential Factor In Nursing Retention: A Phenomenological Study, M'Lyn Spinks
Millennial Perceptions Of Leadership As An Influential Factor In Nursing Retention: A Phenomenological Study, M'Lyn Spinks
Doctorate of Nursing Science Dissertations
For years, stakeholders in nursing have anticipated the retirement of the baby-boomer nursing workforce while heralding it as a major factor in a persistent global nursing shortage (American Association of Colleges of Nursing [AACN], 2017). Nursing shortages, known to have a negative impact on patient safety and outcomes, call for strategies to alleviate, if not resolve, issues of retention (Aiken et al., 2017). Authentic leadership, an identified retention factor among professional nurses and associated with improved patient outcomes, has the potential to provide the theoretical support needed to better inform millennial nursing leadership training and development. This phenomenological study explored …
Improving Access To Mental Health Care With Nurse Practitioners, Jessica Whelan
Improving Access To Mental Health Care With Nurse Practitioners, Jessica Whelan
Dissertations
Problem: Over 40% of those with mental illness are untreated since the supply of psychiatrists does not meet the demand. The psychiatric mental health nurse practitioner (PMHNP) may be an adjunct in providing those services. The purpose of this quality assurance study was to evaluate outcomes of care between a PMHNP and a psychiatrist (medical doctor [MD]).
Methods: An observational, descriptive design with a retrospective medical record review of adult patients over a six-month period in a suburban, Midwestern, privately owned psychiatric practice.
Results: A total of 787 individual patients encountered at least one visit (N=787) although 3,679 …
The Opioid Crisis Examined, Anatolly Zekhtser
The Opioid Crisis Examined, Anatolly Zekhtser
BIO4960: Practicum in Biology I
The Opioid Crisis is a national crisis affecting public, social, and economic healthcare. Nearly 50,000 deaths were caused by opioid overdoses in 2017. Current treatments of opioid addictions include the use of methadone and buprenorphine. These medications have been known to reduce opioid dependency, lower tolerances, increase the opioid overdose threshold, and lower overdose mortality. An analysis was conducted on prominent research studies investigating the effectiveness, safety, side effects, and influence of Methadone and Buprenorphine. The meta-analysis confirmed that both drugs are effective opioid agonists that contribute to decreased opioid dependence and increased opioid abstinence. Due to a series of …
A Systematic Comparison Of Lipopolymers For Sirna Delivery To Multiple Breast Cancer Cell Lines: In Vitro Studies, Hamidreza Montazeri Aliabadi, Remant Bahadur Kc, Emira Bousoik, Ashley Barbarino, Bindu Thapa, Melissa Coyle, Parvin Mahdipoor, Hasan Uludağ
A Systematic Comparison Of Lipopolymers For Sirna Delivery To Multiple Breast Cancer Cell Lines: In Vitro Studies, Hamidreza Montazeri Aliabadi, Remant Bahadur Kc, Emira Bousoik, Ashley Barbarino, Bindu Thapa, Melissa Coyle, Parvin Mahdipoor, Hasan Uludağ
Pharmacy Faculty Articles and Research
Small interfering RNA (siRNA) therapy is a promising approach for treatment of a wide range of cancers, including breast cancers that display variable phenotypic features. To explore the general utility of siRNA therapy to control aberrant expression of genes in breast cancer, we conducted a detailed analysis of siRNA delivery and silencing response in vitro in 6 separate breast cancer cell models (MDA-MB-231, MDA-MB-231-KRas-CRM, MCF-7, AU565, MDA-MB-435 and MDA-MB-468 cells). Using lipopolymers for siRNA complexation and delivery, we found a large variation in siRNA delivery efficiency depending on the specific lipopolymer used for siRNA complexation and delivery. Some lipopolymers were …