Medicine and Health Sciences Commons^™

Potential Roles Of Extracellular Vesicles In The Pathophysiology, Diagnosis, And Treatment Of Autoimmune Diseases., Jing Tian, Giacomo Casella, Yuan Zhang, Abdolmohamad Rostami, Xing Li

Department of Neurology Faculty Papers

Since extracellular vesicles (EVs) were discovered in 1983 in sheep reticulocytes samples, they have gradually attracted scientific attention and become a topic of great interest in the life sciences field. EVs are small membrane particles, released by virtually every cell that carries a variety of functional molecules. Their main function is to deliver messages to the surrounding area in both physiological and pathological conditions. Initially, they were thought to be either cell debris, signs of cell death, or unspecific structures. However, accumulating evidence support a theory that EVs are a universal mechanism of communication. Thanks to their biological characteristics and …

Emerging Regenerative Medicine And Tissue Engineering Strategies For Parkinson's Disease., James P Harris, Justin C Burrell, Laura A Struzyna, H Isaac Chen, Mijail D Serruya, John A Wolf, John E Duda, D Kacy Cullen

Department of Neurology Faculty Papers

Parkinson's disease (PD) is the second most common progressive neurodegenerative disease, affecting 1-2% of people over 65. The classic motor symptoms of PD result from selective degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in a loss of their long axonal projections to the striatum. Current treatment strategies such as dopamine replacement and deep brain stimulation (DBS) can only minimize the symptoms of nigrostriatal degeneration, not directly replace the lost pathway. Regenerative medicine-based solutions are being aggressively pursued with the goal of restoring dopamine levels in the striatum, with several emerging techniques attempting to reconstruct the …

Conditions For Combining Gene Therapy With Bone Marrow Transplantation In Murine Krabbe Disease., Mohammad Rafi, Paola Luzi, David A Wenger

Department of Neurology Faculty Papers

No abstract provided.

Curriculum For Hippotherapy For Children With Autism, Brenna Schulte, Kristy Weissling

Honors Program: Senior Projects (Public)

Innovative effective forms of allied health therapies across disciplines including occupational therapy, physical therapy, and speech therapy are being continuously researched and implemented for people with a variety of disabilities. One form of therapy increasing in popularity is Hippotherapy (HPOT). There is a variety of terms related to hippotherapy. More broadly, Equine Assisted Therapy (EAT) is the use of horses to promote physical and mental health and can be utilized for a wide variety of disabilities, such as ADHD and Autism, as well as physical disabilities such as cerebral palsy. HPOT occurs when OT, PT, and ST professionals utilizes horse …

Pharmaceutical Manufacturing In The 21st Century: Identification And Analysis Of Key Elements, Robert N. Mills

Honors Program: Senior Projects (Public)

The availability of quality pharmaceutical products impacts the lives of the global population on a daily basis. The importance of product availability and quality within pharmaceutical manufacturing requires that quality systems put into place are capable of accurately and robustly capturing the quality compliance, or lack thereof, of the various stages of production. This review intends to analyze current expert-recommended best practices within key elements of a pharmaceutical manufacturing quality control system and provide recommendations throughout. The quality elements discussed include Quality by Design method validation, necessary equipment determination, and equipment qualification, followed by documentation control and data flow.

High Lymph Node Positive To Sampled Ratio As A Potential Indication For Postoperative Radiation Therapy In Patients With Pn2 Non-Small-Cell Lung Cancer, Nikhil P Mankuzhy, Muayad F Almahariq, Craig W Stevens, Thomas J Quinn

Articles

Background: The role for postoperative radiation therapy (PORT) for patients with non–small-cell lung cancer (NSCLC) with mediastinal lymph node (LN) involvement (pN2 disease) is controversial. We performed a SEER analysis comparing surgery alone with PORT among patients with pN2 NSCLC. As we await the final results of the LUNG ART trial, a subset of patients with a high LN positive to sampled (LPR) ratio may benefit from PORT. Patients/methods: Patients with pN2 NSCLC, ranging from 1989-2016, were assessed from the Surveillance, Epidemiology and End Results (SEER) database. A propensity score (PS)-matched, inverse probability of treatment weighting (IPTW) analysis was conducted …

Encountering Grief: Exploring The Value Of Art Therapy For Bereaved Adults, Paul Moynihan

Theses

This extended literature review explores the value of art therapy interventions for bereaved adults, with a particular emphasis on its application for individuals with histories of insecure attachment. A review of literature in the areas of bereavement and attachment considers how attachment insecurities present as a risk factor for complications in the grieving process with a subsequent focus on the implications for therapeutic intervention. A review of literature in art therapy, related areas of psychoanalysis and creativity aims to highlight the distinct value that art therapy could offer this particular subgroup of bereaved adults in adapting to grief. An incorporation …

Survey Of Occupational Therapy Students' Attitudes, Knowledge And Preparedness For Treating Lgbt Clients, Deborah J. Bolding, Vivian Rodriguez, Helen Nguyen, Laurie A. Drabble

Faculty Research, Scholarly, and Creative Activity

Members of lesbian, gay, bisexual and transsexual (LGBT) populations are sexual and gender minorities and are at risk for significant health disparities compared to heterosexual populations. This study examined occupational therapy students’ and recent graduates’ (n=435) basic knowledge, clinical preparedness and attitudinal awareness for working with LGBT clients using the Lesbian, Gay, Bisexual, and Transgender Development of Clinical Skills Scale (LGBT-DOCSS; Bidell, 2017). Students in the study generally rated themselves low (between three and four on a seven-point scale) on questions related to clinical preparedness, indicating they felt they did not have adequate training relative to working with LGBT clients. …

Prevalence And Types Of Incivility In Occupational Therapy Fieldwork, Deborah J. Bolding, Travis Dudley, Adrienne Dahlmeier, Lauren Bland, Aimee Castro, Adrianna Covarrubias

Faculty Research, Scholarly, and Creative Activity

Civility between health professions students and fieldwork educators enhances positive learning outcomes, while incivility can lead to stress, loss of confidence, mistakes, disengagement, and decreased patient outcomes. A survey of recent graduates of occupational therapy programs (N = 247) explored the prevalence and types of incivility and bullying experienced during their Level II fieldwork experiences. Respondents reported that incivility in fieldwork education was widespread, with more severe experiences of bullying reported by 16% of respondents. Occupational therapy programs and fieldwork educators must take an active role in prevention and management of uncivil behaviors, and promote positive academic and patient care …

Pharmacists Improve Door To Needle Times In The Emergency Department, Kevin Phan, Megan Degener

Books, Presentations, Posters, Etc.

No abstract provided.

The Effect Of Dyad Rounding On Collaboration And Patient Experience, Amy Christensen, Korby Miller, Jason Neff, Rusty A. Moore, Sharee Hirschi, Katreena Collette Merrill

Faculty Publications

Communication among the healthcare team is essential to providing high-quality patient care. In the hospital, nurses care for multiple patients during their shift. Physicians or advanced practice clinicians (APCs) visit hospitalized patients daily to update orders, complete assessments, and contribute to care plans. One method to ensure that healthcare providers communicate effectively is interdisciplinary, or dyad, rounding in the hospital. This consists of purposeful rounding on each patient by the nurse and the physician or APC together to review the patient's status and update the care plan. When healthcare providers and nurses round together, it improves communication, patients are more …

Quetiapine And Wolff-Parkinson-White Syndrome, Michael Chen, Hassaan Gomaa, Alonso Cortez-Resendiz, Christopher Martin, Andrew Francis, Alfredo Bellon

Department of Psychiatry and Human Behavior Faculty Papers

Quetiapine is occasionally associated with cardiovascular adverse effects such as QTc prolongation. QTc prolongation is a side effect that requires monitoring in order to avoid more serious cardiac complications. One particular understudied area is the potential for antipsychotics to elicit electroconduction abnormalities in patients with Wolff-Parkinson-White (WPW) Syndrome. In the present report, we describe a case of quetiapine overdose in a patient with WPW.

Checklist-Ethical Analysis And Decision-Science, Melinda Wilding

Bioethics Program of Study

No abstract provided.

Negotiating The Boundaries Of The Medical Model: Experiences Of People With Epilepsy, Stephanie Kılınç, Carol Campbell, Alison Guy, Anna Van Wersch

All Works

© 2019 Elsevier Inc. People with epilepsy (PWE) continually report dissatisfaction with the support they receive, particularly in regard to their psychological wellbeing. With its focus on optimal seizure control, epilepsy treatment is entrenched in the medical model of illness, despite growing evidence of the broader psychosocial impact of the condition. This study aimed to explore how PWE experience healthcare in the context of their lives. Semistructured interviews were conducted with thirty-nine adults with epilepsy from across the UK. An adapted version of interpretative phenomenological analysis (IPA) was conducted, and three superordinate themes were identified. Firstly, “negotiating the space between …

ผลของสารทำอิมัลชันต่อคุณสมบัติและความคงตัวของแอสตาแซนทีนนาโนอิมัลชันสำหรับรับประทาน, พรรณรัตน์ นงนวล

Chulalongkorn University Theses and Dissertations (Chula ETD)

แอสตาแซนทีนเป็นสารต้านออกซิเดชันที่มีฤทธิ์แรงซึ่งมีผลิตภัณฑ์จำหน่ายในรูปแบบเม็ดและแคปซูลสำหรับรับประทาน อย่างไรก็ตาม แอสตาแซนทีนมีข้อจำกัดด้านการดูดซึมเข้าสู่ทางเดินอาหาร จึงมีการนำระบบนาโนอิมัลชันมาใช้ในการพัฒนาเป็นระบบนำส่งแอสตาแซนทีน โดยทำการศึกษาผลของชนิดและความเข้มข้นของสารทำอิมัลชันต่อคุณสมบัติและความคงตัวของตำรับแอสตาแซนทีนนาโนอิมัลชันชนิดรับประทาน โดยใช้น้ำมันรำข้าว และใช้สารทำอิมัลชันเดี่ยว (โซเดียมเคซิเนต 1, 3, 5% หรือ พอลิซอร์เบต 80 4, 6, 8%) และใช้สารทำอิมัลชันผสมทั้งสองชนิด ผลการศึกษาพบว่า ขนาดหยดอนุภาคของตำรับนาโนอิมัลชันเปล่าที่ใช้สารทำอิมัลชันเดี่ยวโซเดียมเคซิเนตใหญ่กว่าตำรับที่ใช้สารทำอิมัลชันเดี่ยวพอลิซอร์เบต 80 และการเพิ่มความเข้มข้นของพอลิซอร์เบต 80 ส่งผลให้ขนาดหยดวัฏภาคภายในลดลงอย่างมีนัยสำคัญ (p<0.05) สำหรับตำรับที่ใช้สารทำอิมัลชันผสม การเพิ่มความเข้มข้นของสารทำอิมัลชัน ทำให้ขนาดหยดวัฏภาคภายในมีขนาดเล็กลงและมีค่าศักย์ไฟฟ้าซีต้าอยู่ระหว่างการใช้สารทำอิมัลชันเดี่ยว 2 ชนิด จากการศึกษาความคงตัวทางกายภาพภายใต้สภาวะเร่งร้อน-เย็น จำนวน 6 รอบ พบว่า ทุกตำรับที่ใช้สารทำอิมัลชันเดี่ยวและตำรับที่ใช้สารทำอิมัลชันผสมที่มีโซเดียมเคซิเนต 1% มีความคงตัวทางกายภาพที่ดี จากนั้น เลือกใช้สารทำอิมัลชันที่ความเข้มข้นน้อยที่สุดและให้ความคงตัวที่ดี นำมาเตรียมนาโนอิมัลชันที่บรรจุแอสตาแซนทีน โดยเลือกใช้สารทำอิมัลชันเดี่ยว 1% โซเดียมเคซิเนต, 4% พอลิซอร์เบต 80 และสารทำอิมัลชันผสมทั้งสองชนิดที่ความเข้มข้นเดียวกัน จากการศึกษาความคงตัวทางกายภาพและเคมี ที่อุณหภูมิ 5 °C และ 25 °C เป็นเวลา 100 วัน พบว่า ที่อุณหภูมิ 5 °C ตำรับแอสตาแซนทีนนาโนอิมัลชันมีความคงตัวทางเคมีดีกว่าที่อุณหภูมิ 25 °C และตำรับที่ใช้สารทำอิมัลชันผสมมีความคงตัวทางเคมีดีกว่าตำรับที่ใช้สารทำอิมัลชันเดี่ยวโซเดียมเคซิเนต และพอลิซอร์เบต 80 ตามลำดับ ผลการศึกษาที่ได้สามารถนำไปประยุกต์ใช้ในการพัฒนาระบบนำส่งแอสตาแซนทีนในรูปแบบนาโนอิมัลชันสำหรับรับประทานต่อไป

I Don’T Want To Go Back: Examining The Return To Physical Workspaces During Covid-19, Zihan Liu, Drake Van Egdom, Rhona Flin, Omolola Adepoju, Ramanari Krishnamoorti

Research Collection Lee Kong Chian School Of Business

Objective: We study employee perspectives on return to physical workspaces to ultimately inform employers' and policy makers' decision making around the return to work during COVID-19. Methods: We tested the three-component conceptual model using survey data collected in the United States in May 2020 from samples of energy workers (N = 333). Results: Women, non-Caucasians, and employees living in multi-generational households were less willing to return. Concerns about childcare were negatively related to willingness to return, whereas organizational strategies for mitigating COVID-19 transmission at work were positively related to willingness to return. COVID-19 infections in an employees' network were also …

Doctor-Patient Communication: The Experiences Of Black Caribbean Women Patients With Diabetes, Rosanne Paul-Bruno

Theses and Dissertations

This applied dissertation was designed to examine the verbal and non-verbal communication experiences of Black Caribbean diabetic women patients with their doctors, in order to provide a better understanding of the essential aspects of doctor- patient communication and their experiences as they managed their condition. Black Caribbean women have been disproportionately impacted by medical conditions such as diabetes. It has been a documented fact that minorities experience disparities in the health care system at different levels and doctor-patient communication is no exception. Poor doctor-patient communication has been known to hinder patients’ health outcomes, and therefore warrants such studies to increase …

Arabic Version Of The Personality Inventory For The Dsm-5 (Pid-5) In A Community Sample Of United Arab Emirates Nationals, Olga Coelho, Rute Pires, Ana Sousa Ferreira, Bruno Gonçalves, Maryam Aljassmi, Joana Stocker

All Works

© 2020 Coelho et al. Background: Section III of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) proposes a model for conceptualizing personality disorders in which they are characterized by impairments in personality functioning and maladaptive personality traits. The Personality Inventory for DSM-5 (PID-5) is a self-report measure that assesses the presence and severity of these maladaptive personality traits. Objective: The current study examined the reliability and validity of the Arabic version of the Personality Inventory for DSM-5 (PID-5) to measure maladaptive personality traits in the Emirati population of the United Arab Emirates. Methods: The Arabic version of the …

An International Fieldwork Placement: A Mixed Methods Study, Dianna Lunsford, Kristin A. Valdes

Journal of Occupational Therapy Education

The purpose of this study was to evaluate the impact of an international fieldwork placement on occupational therapy doctoral (OTD) students’ cultural competence, community engagement, and ethical leadership. This study used a mixed methods approach. The Public Affairs Scale (PAS) was used to gather pre and post placement data on cultural competence, community engagement, and ethical leadership. Qualitative data was themed from a reflection paper along with researcher field notes from a fieldwork placement to Ibarra, Ecuador. Eleven OTD students participated in the study. The study demonstrated a convergence of the data in the area of cultural competence and responsiveness. …

Pharmacokinetics And Antibacterial Activity Of Fosfomycin Against Escherichia Coli From Urinary Tract Infected Dogs, Nattha Jariyapamornkoon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Using old or uncommon drugs as alternative choices are interesting option to avoid drug resistance problems. Fosfomycin is an old antibacterial drug with broad spectrum and excreted via urine in active form. Fosfomycin tromethamine (FOS) has been approved to treat uncomplicated urinary tract infection (UTI) in women by FDA. However, in dogs, FOS data is inadequate and precise dosages have not been established yet. Thus, this study aims to determine pharmacokinetics (PK) and pharmacodynamics (PD) of FOS in E. coli from dog with UTI. A total of 6 healthy male beagle dogs were administered with FOS in 3 different dosages …

Unf Covid-19 Testing: Informed Consent, University Of North Florida

UNF COVID-19 Response

Consent form for COVID-19 testing

Covid-19 Self-Screening Guidance, Unf Human Resources

UNF COVID-19 Response

No abstract provided.

Unf Covid-19 Education Program, Center For Professional Development And Training

UNF COVID-19 Response

No abstract provided.

Emergency Relief For Unf Students, University Of North Florida

UNF COVID-19 Response

As part of University of North Florida's response to the COVID-19 Pandemic, it crowdfunded emergency relief for UNF students.

Unf Tennis Complex Covid-19 Protocol, University Of North Florida Athletics

UNF COVID-19 Response

UNF Tennis Complex Covid-19 protocols

Unf Preschool Covid-19 Pandemic: Policy For Lab Tested Positive Case, Unf Preschool

UNF COVID-19 Response

Preschool Policy on Covid-19 positive cases

Cares Act Student Emergency Aid Funding Faqs, Unf One-Stop Student Services

UNF COVID-19 Response

Frequently Asked Questions on the Cares Act and Student funding

Covid-19 Information Libguide, Thomas Carpenter Library

UNF COVID-19 Response

Modified Library protocols, policies, and procedures 2020

Self-Quarantine/Isolation Procedures, Unf Human Resources

UNF COVID-19 Response

Covid Quarantine and isolation protocols

A Rare Case Of Herpes Zoster Ophthalmicus After Photodynamic Therapy, Madison Bradley, Sonal Muzumdar, Neda Shahriari, Marti J. Rothe, Madina Falcone

Biology Undergraduate Publications

Dear Editors:

Topical photodynamic therapy (PDT) is frequently used in dermatology to treat actinic keratoses (AKs) and superficial nonmelanoma skin cancers (Ibbotson et al., 2019). Herein, we present an extremely rare case of herpes zoster ophthalmicus (HZO) after PDT.