Medicine and Health Sciences Commons^™

Modulation Of K V 7 Channel Deactivation By Pi(4,5)P 2, Carlos A. Villalba-Galea

School of Pharmacy Faculty Articles

The activity of K_V7 channels critically contributes to the regulation of cellular electrical excitability in many cell types. In the central nervous system, the heteromeric K_V7.2/K_V7.3 channel is thought to be the chief molecular entity giving rise to M-currents. These K⁺-currents as so called because they are inhibited by the activation of Gq protein-coupled muscarinic receptors. In general, activation of Gq protein-coupled receptors (GqPCRs) decreases the concentration of the phosphoinositide PI(4,5)P₂ which is required for K_V7 channel activity. It has been recently reported that the deactivation rate of K …

Impact Of Passive Range Of Motion Exercises And Stretching In Knee Osteoarthritis Pain During Walking, Dominique Marchelle Ottonello

Browse all Theses and Dissertations

Knee osteoarthritis (KOA), is globally prevalent source of disability for the elderly. This degenerative malady progresses with age and has no cure. It manifests in gait changes and affects overall quality of life. Exercise therapy has been shown to improve knee joint range of motion, stiffness and pain due to KOA. This improvement is due in part to the direct relationship between muscle strength and joint stability. The purpose of this study is to examine how a passive range of motion (ROM) exercises and stretching regimens affect gait-alterations and associated pain from KOA experienced during walking. Nine KOA subjects were …

The Scoop, Vol. 6 Issue 10, January 2020, Health Sciences Library

Volume 6

Latest news and events from the Health Sciences Library in our monthly newsletter for January 2020.

Non-Invasive Retrieval Of Prefabricated Zirconia Crowns With Er,Cr:Ysgg Laser From Primary And Permanent Teeth, Connor W. Mccall Dds

Theses and Dissertations

Purpose: Compromised tooth structure on permanent and deciduous teeth in the pediatric population is increasingly being restored with tooth-colored prefabricated zirconia crowns. These restorations may need to be removed or replaced with permanent crowns. The purpose of this in vitro study was to explore the use of an Er,Cr:YSGG laser for removal of prefabricated zirconia crowns cemented with RMGI as a non-invasive alternative to rotary instruments.

Methods: Thirteen permanent and 12 primary molars were prepared to dentin and prefabricated zirconia crowns were passively fitted and cemented with two resin modified glass ionomer cements. The irradiation parameters for ErCR:YSGG were 4.5 …

Process Factors Affecting Reperfusion Time In Patients Presenting With St-Segment Elevation Myocardial Infarction (Stemi), Richard R. Wall

Theses and Dissertations

Abstract PROCESS FACTORS AFFECTING REPERFUSION TIME IN PATIENTS

PRESENTING WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION (STEMI) By Richard R. Wall MSRS, RT(R)(CT)(CI), RCIS

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2020.

Dissertation Chair: Jeffrey S. Legg Ph.D. Associate Professor and Chair, Department of Radiation Sciences

An ST-segment myocardial infarction (STEMI) occurs when the blood flow to the myocardium is suddenly and completely blocked causing the myocardium to become ischemic. A STEMI is a life-threatening condition that necessitates emergent medical treatment. Research has shown that longer …

Selenomonas Sputigena: Growth Conditions And Projected Virulence Factors Of An Emerging Oral Pathogen, Kayla A. Keller

Theses and Dissertations

Periodontal diseases are ubiquitous diseases. They can affect people through a chronic infection that happens over a lifetime, but also as an aggressive infection that afflicts the younger population. It not only results in tooth loss and a lower quality of life, but it can also lead to fatal secondary infections like cervical cancer, heart disease, and Alzheimer’s disease. This study looks at Selenomonas sputigena, an emerging oral pathogen, that has been hypothesized to contribute to periodontal disease. It has been linked to fatal septicemia and has been found in increased abundance within the oral biofilm during peak infection. …

Enhancing Chemosensitivity Of Lung Cancers By Manipulating The Tumor Microenvironment: Local Lung Delivery And Nanocarrier-Based Therapies, Hanming Zhang

Theses and Dissertations

Cancer is the second leading cause of death in United States causing an estimated six hundred thousand death in 2019. Among different types of cancer, lung cancer is the leading cause of cancer related death in both male and female. While targeted therapy and immunotherapy have shown promising clinical outcomes, currently there remain a significant proportion of patients who do not benefit from these strategies or who cannot tolerate them, making Pt based doublet chemotherapy still an indispensable component in almost all stages of treatment. However, partially due to the poor tumor distribution of small molecule drug, the development of …

Reducing Disparities In Smoking For Adults With Mental Illness: Are U.S. Tobacco Prevention Policies Effective?, L. Morgan Snell

Theses and Dissertations

One in five people in the U.S. are estimated to experience “any mental illness” (AMI); however this group represents an estimated 40% of the annual, adult cigarette consumption in the U.S. Tobacco prevention policies have been successful at reducing smoking prevalence among the U.S. population as a whole, however it is unclear whether these efforts have had significant impact on tobacco use rates among individuals with AMI. The three papers that comprise this project combined longitudinal, nationally-representative data and online behavioral experiments from U.S. adults to compare demand for cigarettes among adult smokers with and without AMI. Taken together, our …

Analysis Of Adult Neural Retina Extracellular Vesicle Release, Rna Transport And Proteomic Cargo, Jason Mighty, Jing Zhou, Alberto Benito-Martin, Sami Sauma, Samer Hanna, Onyekwere Onwumere, Cui Shi, Martin Muntzel, Moira Sauane, Michael Young, Henrik Molina, Dianne Cox, Stephen Redenti

Publications and Research

PURPOSE. Extracellular vesicles (EVs) contain RNA and protein cargo reflective of the genotype and phenotype of the releasing cell of origin. Adult neural retina EV release, RNA transfer, and proteomic cargo are the focus of this study.

METHODS. Adult wild-type mouse retinae were cultured and released EV diameters and concentrations quantified using Nanosight. Immunogold transmission electron microscopy (TEM) was used to image EV ultrastructure and marker protein localization. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze retinal cell transcripts present in EVs. Super-resolution microscopy was used to image fluorescent (green) RNA and (red) lipid membrane labeled EVs, released …

Environmental Impacts On The Occupations Of Non-Binary Individuals, Meghan Ballog, Maria Mayela Carranza, Katherine Lee

Occupational Therapy | MSOT Capstone Projects

Understanding the link between occupations, gender identity, and the environment is fundamental to the comprehension of the occupational participation of non-binary individuals. Occupations are used to express an individual’s personal and social identity and serve as a modality for identity “growth and reconstruction” (Laliberte-Rudman, 2002). Beagan et al. (2012) reveal that transgender individuals use occupations to shape and project their identity; the inability to engage in occupations that align with an individual’s identity (particularly gender identity) resulted in distress, a sense of emptiness, and occupational deprivation. Current research addresses the transgender population but fails to distinguish between the binary and …

Can Human Neurological Tests Of Consciousness Be Applied To Octopus?, Benedetta Cecconi, Jitka Annen, Steven Laureys

Animal Sentience

If the anatomy, physiology and behaviour of a species differ substantially from our own, can we infer that the species is unconscious? In the daily clinical care of patients with disorders of consciousness we face many similar challenges: our current approach with these patients - a combination of behavioural and brain imaging-based assessments - might also be a viable route to investigating octopus consciousness.

Perceived Benefits And Barriers Of Static Stretching In Exercisers, Meg Rolfzen (Thacker), Susan Evans, Jenenne A. Geske

EMET Projects

No abstract provided.

Using The Rapid Assessment For Adolescent Preventative Services Risk Screening Tool To Identify Depression In Two Omaha High Schools, Annie Ballén, Melanie Menning, Jenenne A. Geske

EMET Projects

No abstract provided.

Acute Mesenteric Thrombosis: A Hematologist Perspective, Bushra Moiz, Zaid Muslim, Zahraa Farrukh Siddiqui, Hasnain Zafar

Department of Pathology and Laboratory Medicine

No abstract provided.

Kidney Stone Analysis And Spiritual Guides (Pir Faqir): The Known-Unknowns, Lena Jafri, Aysha Habib Khan, Humaira Asif

Department of Pathology and Laboratory Medicine

No abstract provided.

Glycogen Storage Diseases-Time To Flip The Outdated Diagnostic Approach Centered On Liver Biopsy With The Molecular Testing, Sibtain Ahmed, Bushra Afroze

Department of Pathology and Laboratory Medicine

The glycogen storage diseases (GSDs) are a group of inherited metabolic disorders that result from a defect in any one of several enzymes required for either glycogen synthesis or glycogen degradation. The traditional diagnostic approach is based on the invasive hepatic or muscle biopsies, which are neither cost effective nor convenient. Molecular (gene testing) has emerged over the course of past few years as a robust alternative diagnostic tool, which not only confirms the diagnosis of GSDs but also clearly differentiates the types of GSDs allowing the initiation of the type-specific appropriate treatment for the particular type of GSDs. The …

Kidney Stone Analysis And Spiritual Guides (Pir Faqir): The Known-Unknowns, Lena Jafri, Aysha Habib Khan, Humaira Asif

Department of Pathology and Laboratory Medicine

No abstract provided.

Use Of Pefloxacin As A Surrogate Marker To Detect Ciprofloxacin Susceptibility In Salmonella Enterica Serotypes Typhi And Paratyphi A, Safia Moin, Mohammad Zeeshan, Sidra Laiq, Ahmed Raheem, Afia Zafar

Department of Pathology and Laboratory Medicine

Objective: To determine the use of pefloxacin as a surrogate marker to detect fluoroquinolone (ciprofloxacin) susceptibility against Salmonella enterica serotypes Typhi and Paratyphi A.
Methods: The prospective, descriptive cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from September 2016 to March 2018, and comprised Salmonella Typhi and Paratyphi A isolates of blood cultures. Disk susceptibility tests and broth microdilution to test minimum inhibitory concentration were performed as per standard guidelines. Data was analysed using SPSS 21.
Results: Of the 138 isolates, 91(66%) were intermediate resistant to ciprofloxacin but were resistant to pefloxacin, 42(30%) were resistant to both …

The Contribution Of Frequency Discrimination Ability To Auditory Temporal Patterning Tests In Children, Ashley G. Flagge, Tara M. Davis, Victoria Henbest

Ashley Flagge Publications

Purpose: The Pitch Patterns Test (PPT) and Duration Patterns Test (DPT) are clinical auditory processing tests that evaluate temporal patterning skills based on pitch (PPT) or duration (DPT) aspects of sound. Although temporal patterning tests are categorized under the temporal processing domain, successful performance on the PPT also relies on accurate pitch discrimination. However, the relationship between pitch discrimination ability and temporal patterning skills have not been thoroughly evaluated. This study examined the contribution of pitch discrimination ability to performance on temporal patterning in children through the use of a pitch discrimination task and the PPT …

2020-2021 Nursing Graduate Msn-Fnp Handbook, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2020-2021 Graduate Student Handbook for the Department of Nursing at Morehead State University.

Exploring Cryotherapy As A Therapeutic Approach For Stress-Induced Tension Headaches In College Students, Mona Hassan Abdelaal

Nursing

ABSTRACT Tension-type headaches and stress are common problems for students. It is one of the most neglected headache types, with prevalence of ~ 15–20% in population-based studies. Alternative and complementary medicine such as cryotherapy is effective for relieving physical and psychological pain; using ice compresses by placing it at the back of the neck, leads to relief of tension and anxiety, and gives the feeling of relaxation and full of energy for doing daily life activities. The findings from this study provide the basis for the formulation of future research questions that can explore the effect of cryotherapy on the …

Postnatal Outcomes Of Genitourinary Abnormalities Diagnosed On Antenatal Ultrasound, Andrea Johnson, Meredith Rochon Md, Michele R. Clement Md, Ashley Costa Md, Kristin Aneskevich, Joanna Bock

USF-LVHN SELECT

No abstract provided.

A Qualitative Analysis Of Resident Report Medication Safety Events In The Emergency Department, Charles Soares, Bryan G. Kane Md

USF-LVHN SELECT

No abstract provided.

A Cross-Sectional Study Of The Information-Seeking Behaviors Of An Independent Academic Medical Center Staff, Robert Postlethwaite, Robert D. Barraco Md, Mph, Rahul Mhaskar, Jordan Davis, Matthew Molnar, Nicholas Werbeckes, Maria Karagias, S Reynolds, Angela Davis, Bryan G. Kane Md

USF-LVHN SELECT

No abstract provided.

Improving Emergency Physician Availability For Trauma Cases In A Pod-Based System, Hernando Castillo Ms, Richard S. Mackenzie Md

USF-LVHN SELECT

No abstract provided.

Feasibility Of Implementation Of An Emergency Department Discharge Opioid Taper Protocol At Lehigh Valley Health Network, Sarah Iqbal, Gillian A. Beauchamp Md

USF-LVHN SELECT

No abstract provided.

Selective Service: Experiences Of Speech-Language Pathologists Serving Underrepresented Populations, Maymuna Najam Jamil

Senior Honors Theses and Projects

Members of underserved populations, particularly those of low socioeconomic standing, are less likely to receive speech-language pathology services. Through a series of indepth interviews, this study observes the experiences of speech-language pathologists working with underserved populations in order to understand how they help such populations. The subjects include at least one speech-language pathologist from each of the following settings: school, private practice, hospital, and skilled nursing facility. Results of this study yield common themes in working with members of underserved populations, as well as implications for improving the accessibility of speech-language pathology services.

Nursing Student Confidence In Implementing Comfort Measures With The Laboring Client, Heily Alvelo-Saada

Senior Honors Theses and Projects

Student self-efficacy in implementing comfort measures with the laboring client is examined at a baccalaureate school of nursing (BSN) in the midwest. Results indicated that students were not fully confident in their ability to perform these comfort measures towards the end of their Nursing Care of Childbearing Families lecture and clinical courses. These findings suggest that teaching methods are examined to find areas that could use improvement in order to increase student self-efficacy in implementing comfort measures with the laboring client.

The Implications Of Gut Health On Mental Health, Cali Curlee

Senior Honors Theses and Projects

The neurotransmitter deficiency hypothesis suggests that neurotransmitter imbalance is the physiologic cause for mental health conditions like depression and anxiety. With up to 90% of serotonin produced in the gut, it is of particular interest whether diet may influence this balance. The current research seeks to identify a connection between one’s intake of microbiome-influencing foods/beverages and mental health status. The hypothesis of the study is that participants who regularly consume greater amounts of pre/probiotic foods will have a decreased prevalence of depression and anxiety, relative to those who rarely consume pre/probiotic foods. Differences in survey data were not statistically significant, …

Determining K-Levels For Lower Extremity Amputations: Are We Documenting Enough?, Michelle Hong, James J. Goodreau Md

USF-LVHN SELECT

No abstract provided.