Medicine and Health Sciences Commons^™

Psychiatric Comorbidities Increase Cost And Length Of Hospitalization In Adolescents And Young Adults With Chronic Medical Conditions, Reem Hasan, Christina Nicolaidis

School of Social Work Faculty Publications and Presentations

Patients with chronic conditions of childhood experience exacerbations during adolescence and young adulthood, leading to higher rates of hospitalizations and burden of disease compared to earlier childhood or later adulthood.1-3 Little is known about the epidemiology of hospitalization of adolescents and young adults with childhood-onset chronic medical conditions. We describe the impact of psychiatric comorbidity on the length of stay and cost of hospitalization.

Associations Of Traffic Related Air Pollution With Physical Activity And Cardiorespiratory Health Outcomes In At-Risk Populations From El Paso, Texas, Juan Aguilera

Open Access Theses & Dissertations

Exposure to air pollution from traffic-related emissions is a considerable preventable cause of respiratory and cardiovascular diseases. However, the impacts on at-risk populations, such as children with asthma and low-income residents, are yet to be fully understood in the border city of El Paso, TX. This dissertation focused on the most common traffic-related pollutants which include particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), and ozone (O3). The research described in this work provides an overview of air pollution measurements and shares insights from three different studies in our region.

People with asthma are more likely adversely affected by traffic …

Evaluating The Impact Of The In-Store Programming And Outreach Coalition (Ipoc) On Increasing Access To Healthy Food And Healthcare Services In Paso Del Norte Region: First-Person Account Of Stakeholders' Perspective, Dennis Nyachoti

Open Access Theses & Dissertations

Grocery stores can provide a conducive environment for interventions targeting healthy eating and access to health services, particularly in low-income communities. Nationally, several organizations have implemented grocery store interventions and have shown impact on perceptions of purchasing nutritious food, especially by raising awareness of fruits and vegetables. However, most of those programs have not been implemented in a coordinated manner despite being delivered in the same location. Collaboration of local health promotion organizations with grocery stores could increase consumers' access to and selection of healthy foods, as well as access to and use of services.

This evaluation of the In-Store …

Benchmarking Machine Learning Methods For Molecular Property Prediction, Govinda Bahadur Kc

Open Access Theses & Dissertations

Machine learning (ML) techniques have been widely applied in a variety of areas ranging from pattern recognition, natural language processing, and computer games to self-driving cars, clinical diagnostics, and molecular structure prediction easing day to day life of human beings. Drug discovery is an expensive, complex, and time taking process. Currently, the pharma industry is hoping to leverage machine learning methods in expediting the drug discovery process. Molecular property prediction is one of the most important tasks in drug discovery. While developing a new drug relies on a proper understanding of molecular properties, there has been great interest in the …

Intensity Of Resistance Training Via Self-Reported History Is Critical In Properly Characterizing Musculoskeletal Health, Hawley Almstedt, Joseph W. Labrie, Todd Shoepe

Health and Human Sciences Faculty Works

Background: Intensity of resistance training history might be omitted or poorly ascertained in prescreening or data questionnaires involving musculoskeletal health. Failure to identify history of high-versus low-intensity training may overlook higher effect sizes with higher intensities and therefore diminish the precision of statistical analysis with resistance training as a covariate and bias the confirmation of baseline homogeneity for experimental group designation. The purpose was to determine the degree to which a single question assessing participant history of resistance training intensity predicted differences in musculoskeletal health. Methods: In the first research aim, participants were separated into groups with a history (RT) …

Heart Rate Variability And Cardiovascular Adaptations Among Cancer-Survivors Following A 26-Week Exercise Intervention, Heather P. Tarleton

Health and Human Sciences Faculty Works

Cardiotoxicity as a result of cancer treatment contributes to autonomic dysfunction and decreased cardiorespiratory fitness among cancer survivors. These deleterious cardiovascular outcomes reduce the survival prognosis for cancer patients and contribute to poor quality of life among survivors. Exercise interventions have been shown as effective in mitigating treatment-related side effects. However, previously published interventions have not explored the potential for improvement in autonomic dysfunction (heart rate variability, HRV). This study examined cardiovascular adaptations in cancer survivors (n = 76) who participated in a 26-week intervention consisting of combined aerobic and resistance training (CART). The most noteworthy improvements occurred during the …

Exploring Female University Students’ Views Of Campus Engagement In Chaarg, Lia Giffels

Williams Honors College, Honors Research Projects

There are positive benefits to group exercise, such as motivation and improved performance. However, strength training poses a gender disparity, with less participation among females. Changing Health, Attitudes, + Actions to Recreate Girls (CHAARG) is a student organization to empower females to reach health goals by participating in a comprehensive fitness program. Purpose: This investigation explores female college students’ views of their experience in CHAARG. Understanding how to engage more women in strength training and healthy lifestyles may fuel increased adherence rates. Methods: Q methodology will be used to investigate the viewpoints of female students’ members in a large Midwest …

The Delicacy Of Breath: Tribute To Cystic Fibrosis, Natalie Minns

Williams Honors College, Honors Research Projects

A simple breath is something that we do not completely focus on enough in the art of dance, and it can be something that we often take for granted. For my project, my goal is to not only shed light on the simple breath, but to delve deeper into its importance in someone living with a breathing condition. My ultimate goal is to allow these separate entities to coexist through a piece of choreographic work. Through the art of dance, I want to be able to bring awareness to cystic fibrosis (CF) in a more expansive and exploratory approach. This …

Demographics And Physical Activity Levels Of Esports Athletes At The University Of Akron, Madison Morgan, Patrick Barrett, Madeleine Stoll

Williams Honors College, Honors Research Projects

Esports is rapidly growing and gaining popularity, however there is a lack of research regarding physical activity levels of eSport athletes, especially those at the collegiate level. This study summarizes the current research and findings related to exercise, overall health, and video game performance. All varsity eSport athletes for The University of Akron varsity team were “participants” in this study. A survey tool was designed through Qualtrics (Qualtrics 2020© Provo, UT), an online survey instrument, to assess current physical activity levels, preferences and tolerance for exercise intensity, and perceptions about how physical activity affects gaming performance. This survey was distributed …

Exploring Intuitive Eating Behaviors And Attitudes Among A Sample Of College Students, Kirsten Imhoff, Christin Seher Phd, Rdn, Ld, Kristen Debois Phd

Williams Honors College, Honors Research Projects

Background: This study examined the eating philosophy of college students at a public, four-year institution to build upon prior research of intuitive eating (IE), and to guide on-campus programming and services. Questions on whether IE behaviors and attitudes would differ between students pursuing health and non-health-related careers were also considered.

Methods: The Intuitive Eating Scale-2 (Tylka and Kroon Van Diest, 2013) was replicated into a 33-question Qualtrics survey, and participation was solicited via email. A total of 109 usable surveys were collected with respondents identifying predominantly as female (64.22%), Caucasian (80.73%), and pursuing degrees in disciplines outside of health professions …

Examining Traumatic Bone Fracture Healing Versus Surgical Osteotomies In Canines And Resulting Rates Of Infection, Grace Gsellman

Williams Honors College, Honors Research Projects

The development of osteomyelitis after surgical osteotomies and fracture repair in canines can propose serious health risks, ultimately leading to additional intervention from veterinarians that can become costly for pet owners and effect prognosis for the patient. Preventive measures are currently implemented during surgery and postoperatively. However, infection rates still range from 3.0% to 7.9% (Clark et al., 2018). By examining traumatic bone fracture healing versus surgical osteotomies in canines through the collection of both clinical and radiographic medical records, our primary objective was to further understand the physiological mechanism by which osteomyelitis develops. Limitations related to the collection of …

Effects Of A Strength Training Intervention And Quality Of Life: Case Study On A Sedentary Adult Female, Lucas Frazier

Williams Honors College, Honors Research Projects

The purpose of the project is to evaluate physiological and quality of life changes in a

sedentary, senior-aged (55 or older) female using a six-week strength training

intervention. This case study will instruct how to perform a push-pull-legs split

routine by going to the gym three times per week. Prior to the six week intervention,

both quantitative and qualitative variables will be collected to assess baseline data,

including the subject’s resting heart rate, resting blood pressure, grip strength, one-

repetition maximum on seven whole body exercises (dumbbell bicep curl, tricep

pushdown, barbell bench press, wide-grip lat pull-down, seated dumbbell press, …

Measuring Eating Competence Among Participants Enrolled In A 15-Week Weight Management And Chronic Disease Prevention Program, Delaney Corrin Javens

Williams Honors College, Honors Research Projects

The purpose of this research project is to measure eating competence among participants, ages 35 to 74 years-old, who are enrolled in a 15-week weight management and chronic disease prevention program at Summa Health Equity Center. The objective of this research is to determine whether the cohort's eating competence grew as a result of completing of the program that focuses on nutrition education, behavior modification, physical activity, and cooking demos. This data will be used to help program facilitators determine if the cohort's eating competence grew as a result of the nutrition and behavior modification provided throughout the program. Three …

Home Health Care Resource Binder: A User-Friendly Guide For Crossroads Hospice And Palliative Care, Deanna Eder

Williams Honors College, Honors Research Projects

Patients and families searching for home health care need accurate information regarding the community resources available to them to promote aging in place and to maintain their quality of life. In connection to the social workers at Crossroads Hospice and Palliative Care, the researcher identified a need for a centralized source of up-to-date information regarding local home health care agencies due to the current resource deficit. Social workers and other health care professionals are expected to benefit from a concise list of resources readily available to provide their patients and families with adequate support to make informed decisions about a …

Assessing Morphology Of Iprgcs After Traumatic Brain Injury, Brian Foresi, Matt Smith

Williams Honors College, Honors Research Projects

ipRGCs are retinal ganglion cells that project to visual processing centers of the brain for nonimage forming visual functions. The relation of ipRGCs to tramatic brain injury (TBI) is emerging as data has been published describing ipRGC functional changes in TBI affected military veterans. Major symptomologies of concussions, a mild form of TBI, also overlap with the function governed by sites in the brain with major ipRGC projection percentages. Assesing if a morphological change is occuring in the ipRGCs after a TBI could support the idea of a pathological mechanism of the injury. This study could also indicate further relevance …

Artificial Reverse Shoulder Arthroplasty Joint Project, Michael Rosen, Bailei Hoyng

Williams Honors College, Honors Research Projects

This proposed project will be developing an artificial reverse shoulder arthroplasty joint that focuses on improvements to the Zimmer Biomet Comprehensive Reverse System by freating a unique feature, or features, to the humeral component that focuses on the prevention of dislocation by not limiting the range of motion of men from ages 45 to 65 years.

The development of the this project will utilize the Food and Drug Administration (FDA) medical device design process. This project will involve a total of four Biomedical Engineering students from the University of Akron. Two students, Michael and Bailei, are in the Honors college …

Development Of A Method For The Detection And Quantification Of Various Benzodiazepines And Z-Drugs In Human Blood And Qualitative Identification In Urine Samples Using Liquid Chromatography Mass Spectrometry (Lc-Ms/Ms), Haley Michel

Williams Honors College, Honors Research Projects

This method developed in the toxicology department at the Cuyahoga County Medical Examiner’s Office (CCMEO) detects 40 benzodiazepines and metabolites along with several z-drugs in blood and urine by liquid chromatography tandem mass spectrometry. A sample amount of 0.5 mL was used to detect analytes in postmortem drug facilitated sexual assault and impaired driving cases. Twenty-nine analytes met criteria for quantification while the remaining 14 were used as qualitative indicators. Bias and precision results for quality controls met criteria, staying within ±15% except for clonazolam and etizolam which were within ±20%. Quantitative reporting criteria which included dilution integrity was met …

Enhancement Of The Syncardia Total Artificial Heart For Pediatric Use, Margaret Clark, Madison Marks

Williams Honors College, Honors Research Projects

Pediatric patients with disorders and diseases of the heart have limited options with regards to implantable devices. Many of these implants are ventricular assist devices, which is not always suitable for a patient. Total artificial hearts (TAHs) have supported many adult patients until transplantation, and we believe that they could do the same for pediatric patients. SynCardia has the only Food and Drug Administration (FDA) approved TAH devices. Since SynCardia is the only company with FDA approved TAHs, we decided to modify the design of the SynCardia TAH for use in pediatric patients without compromising the function of the current …

The Relationship Between Intensity Of Fitness Tracker Usage And Motivation, Rachel Cannata, Abigail C. Daugherty, Madison O. Dirocco, Julianne Green, Pial Dasgupta

Williams Honors College, Honors Research Projects

Many college students engage in unhealthy behaviors which may contribute to diseases. Additionally, some students may lack motivation to rectify these behaviors to improve their long-term health. This study assessed the relationship between intensity of fitness tracker usage and motivation among health professions students at a large, public Midwestern university. This non-experimental, correlational study used convenience sampling and a theoretical framework based on Bandura’s Social Cognitive Theory. Online recruitment announcements were emailed and included links to the consent form and survey. Motivation was measured with Deci and Ryan’s modified self-determination tool. Intensity of tracker usage was measured using a scale …

Nasa Dugo (‘It’S In The Blood’): Lay Conceptions Of Hypertension In The Philippines, Gideon Lasco, Jhaki Mendoza, Alicia Renedo, Maureen L. Seguin, Benjamin Palafox, Lia M. Palileo-Villanueva, Arianna Maever L. Amit, Antonio L. Dans, Dina Balabanova, Martin Mckee

Development Studies Faculty Publications

Introduction: Understanding explanatory models is important for hypertension, a leading risk factor for cardiovascular disease and stroke. This article aims to determine what adult patients with hypertension in the Philippines attribute their condition to, how these views might be explained and what the implications are for hypertension management. Methods: This is a qualitative study drawing on 71 semistructured interviews (40 initial and 31 follow-up) and four focus group discussions with patients diagnosed with hypertension. The setting was urban and rural low-income communities in the Philippines. Results: Four prominent perceived causes were identified—genetics, heat, stress and diet—for what patients refer to …

The Chemical Lives Of Young Filipinos, Gideon Lasco

Development Studies Faculty Publications

Many young Filipinos are using a wide array of ‘chemicals’ that structure, and are structured by, their everyday lives. These chemicals - cosmetics, supplements, narcotics, beverages - range from local to foreign, cheap to expensive, licit to illicit; orally ingested to topically applied, and are used for different reasons in a variety of contexts. This chapter analyzes and seeks to make sense of the use of chemicals by young Filipinos.

Department Of Education: Fy2020 Annual Report, Lehigh Valley Health Network

Department of Education

No abstract provided.

Developing Implementation Research Capacity: Longitudinal Evaluation Of The King’S College London Implementation Science Masterclass, 2014-2019, Rachel Davis, Brian Mittman, Madelene Boyton, Aoife Keohane, Lucy Goulding, Jane Sandall, Graham Thornicroft, Nick Sevdalis

Faculty Publications

Background: Despite an increasing number of training opportunities in implementation science becoming available, the demand for training amongst researchers and practitioners is unmet. To address this training shortfall, we developed the King's College London 'Implementation Science Masterclass' (ISM), an innovative 2-day programme (and currently the largest of its kind in Europe), developed and delivered by an international faculty of implementation experts. Methods: This paper describes the ISM and provides delegates' quantitative and qualitative evaluations (gathered through a survey at the end of the ISM) and faculty reflections over the period it has been running (2014-2019). Results: Across the 6-year evaluation, …

Proposing The Mindful Check-In: A Brief Mindfulness Exercise, Michael Viveiros

EWU Masters Thesis Collection

This study investigated the effectiveness and adherence rate of the mindful check-in compared to a traditional mindfulness exercise. This study compared the effects of a traditional mindful breathing exercise and a no-treatment control condition to the mindful check-in on measures of mindfulness, psychological flexibility, affect, compassion, and adherence to the proposed practice schedule. Statistical analyses showed that the mindful check-in reduced negative affect compared to the other two conditions, increased mindful ability on one of the two measures of mindfulness, had a marginally-significant increase in psychological flexibility, and reduced fear of receiving compassion from others and giving compassion to yourself. …

Pneumovirus Infections: Understanding Rsv And Hmpv Entry, Replication, And Spread, Jonathan T. Kinder

Theses and Dissertations--Molecular and Cellular Biochemistry

Pneumoviruses including human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are significant causes of respiratory tract infections globally. Children, elderly, and immunocompromised patients are at the greatest risk for developing severe infections, which can have devastating outcomes. Although these viruses are ubiquitous with significant impacts on human health, there are no antivirals or vaccines available. The only FDA approved therapy is a monoclonal antibody for RSV, given prophylactically during the infectious season, and this treatment is only available for high risk infants. The work presented in this thesis aims to increase our understanding of how these viruses enter, replicate, and …

Physiological Adaptations To Training And Associations With Performance In Division I Cross-Country Runners, Kailyn Renae Sanchez

EWU Masters Thesis Collection

No abstract provided.

The Effects Of Gspt1 Degradation On Serum Calcium, Parathyroid Hormone, And Fibroblast Growth Factor 23 Concentrations In Human Cereblon Knock-In Mice, Kamran Ghoreishi

Theses and Dissertations

Test article CC-325 is a potent oral cereblon (CRBN) modulator that has shown potent G1 to S phase transition 1 (GSPT1) degradation and anti-tumor activity in pre-clinical models. One of the adverse effects associated with CC-325 was dose dependent hypocalcemia, which was determined to be an on-target toxicity.

To investigate the mechanism of hypocalcemia, we conducted a toxicity study in human cereblon (huCRBN) knock-in (KI) mice with CC-325. The huCRBN KI mice are transgenic mice engineered to express human cereblon that is capable of binding to CRBN and degrading GSPT1. Four groups of mice were treated with vehicle (0 mg/kg), …

Insulin-Induced Serine 22 Phosphorylation Of Retinoid X Receptor Alpha Is Dispensable For Adipogenesis In Brown Adipocytes, Jacob Ardenkjær-Larsen, Kaja Rupar, Goda Sinkevičiūtė, Patricia S.S. Petersen, Julia Villarroel, Morten Lundh, Romain Barrès, Atefeh Rabiee, Brice Emanuelli

School of Pharmacy Faculty Articles

Insulin action initiates a series of phosphorylation events regulating cellular differentiation, growth and metabolism. We have previously discovered, in a mass spectrometry-based phosphoproteomic study, that insulin/IGF-1 signalling induces phosphorylation of retinoid x receptor alpha (RXRα) at S22 in mouse brown pre-adipocytes. Here, we show that insulin induces the phosphorylation of RXRα at S22 in both brown precursor and mature adipocytes through a pathway involving ERK, downstream of IRS-1 and −2. We also found that RXRα S22 phosphorylation is promoted by insulin and upon re-feeding in brown adipose tissue in vivo, and that insulin-stimulated S22 phosphorylation of RXRα is dampened by …

Eecp Improves Markers Of Functional Capacity Regardless Of Underlying Ranolazine Therapy, Sanaz Ziad, Jamil Malik, Obinna Isiguzo, Lang Xu, Leqi Chen, Annette Cox, Sachin Shah

School of Pharmacy Faculty Articles

OBJECTIVE: Enhanced external counterpulsation (EECP) and ranolazine are approved treatments for patients with chronic stable angina by the United States Food and Drug Administration (FDA). Whether EECP offers clinical benefits regardless of underlying ranolazine therapy needs further investigation.

METHODS: This was a retrospective evaluation of patients referred to a specialized EECP center. Patients having data on 6-Minute Walk Distance (6MWD) or Duke Activity Status Index (DASI) were categorized into two groups (EECP with ranolazine or EECP only). The primary endpoints were change in 6MWD and DASI before and after a full course of EECP within each of the two groups. …

Does Smoke-Free Legislation Work For Teens Too?: A Logistic Regression Analysis Of Smoking Prevalence And Gender Among Sixteen Years Old In Ireland Using The 1995-2015 Espad School Surveys, Shasha Li, Sheila Keogan, Luke Clancy

Articles

Objectives: To assess the role of tobacco control legislation (TCL) in youth smoking in Ireland. To examine the effects of smoke-free legislation in youth. To consider whether TCL contributed to the gender equalisation in prevalence in 16 years old seen between 2003 and 2015.

Setting Data are from the 4 yearly European School Survey Project on Alcohol and Other Drugs from 1995 to 2015. Total sample size was 12.394. A logistic regression model on grouped data was used. Dependent variable is whether a student was a smoker in last 30 days. Independent variables are time, gender and the policy indicators, …