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Articles 156331 - 156360 of 325328

Full-Text Articles in Medicine and Health Sciences

Clinical Evaluation Of Pituitary Insufficiency In Adult Population, Selvi̇han Beysel, Mustafa Çalişkan, Muhammed Kizilgül, Seyfullah Kan, Mustafa Özbek, Erman Çakal Jan 2020

Clinical Evaluation Of Pituitary Insufficiency In Adult Population, Selvi̇han Beysel, Mustafa Çalişkan, Muhammed Kizilgül, Seyfullah Kan, Mustafa Özbek, Erman Çakal

Turkish Journal of Medical Sciences

Background/aim: This retrospective study aimed to investigate the clinical profile of pituitary insufficiency (PI) in adult population. Materials and methods: One hundred and fifty patients who were diagnosed as having PI between 2012 and 2018 (53.3% female, mean age 48.13 ± 15.83 years) were retrospectively analyzed. Results: Age at diagnosis was higher in females as compared with males (51.13 ± 15.95 vs. 44.70 ± 15.08 years, P = 0.012). The most frequent presenting signs were headache (29.4%) and visual disturbance (19.6%) in general. Females frequently presented with headache (33.3%), whereas males presented with sexual dysfunction (34.4%). The most frequent cause …

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Horse Allergen Sensitivity And Respiratory Symptoms Among Horse Farm Workers, Burcu Baran Ketenci̇oğlu, İnsu Yilmaz, Nuri̇ Tutar, İnci̇ Gülmez, Fatma Sema Oymak Jan 2020

Horse Allergen Sensitivity And Respiratory Symptoms Among Horse Farm Workers, Burcu Baran Ketenci̇oğlu, İnsu Yilmaz, Nuri̇ Tutar, İnci̇ Gülmez, Fatma Sema Oymak

Turkish Journal of Medical Sciences

Background/aim: Sensitivity and symptoms related to animal proteins have been investigated in various occupational groups. However, data from horse farm workers are limited. We aimed to determine horse allergen sensitivity in the horse farm workers, and to evaluate its relationship with respiratory symptoms and functional parameters. Materials and methods: A total of 110 subjects were enrolled in the study. The study group consisted of 80 horse farm workers. Face-to-face surveys, skin prick tests (SPT), and pulmonary function tests (PFT) were performed in the study group. Control group consisted of 30 healthy subjects. SPT and PFTs were also performed for control …

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Factors Associated With Severe Lung Disease In An Adult Population With Cystic Fibrosis: A Single-Center Experience, Berri̇n Er, Ebru Çelebi̇oğlu, Ebru Yalçin, Deni̇z Doğru, Özlem Erden Aki̇, Ömrüm Uzun, Murat Akova, Uğur Özçeli̇k, Nural Ki̇per, Sali̇h Emri̇ Jan 2020

Factors Associated With Severe Lung Disease In An Adult Population With Cystic Fibrosis: A Single-Center Experience, Berri̇n Er, Ebru Çelebi̇oğlu, Ebru Yalçin, Deni̇z Doğru, Özlem Erden Aki̇, Ömrüm Uzun, Murat Akova, Uğur Özçeli̇k, Nural Ki̇per, Sali̇h Emri̇

Turkish Journal of Medical Sciences

Background/Aim: The patients with cystic fibrosis (CF) are living longer compared to the past, but respiratory failure is still the most common cause of mortality. The aim of this study is to investigate factors associated with severe lung disease in a cohort of adult patients with CF. Materials and methods: Demographic data, clinical and laboratory findings of the patients aged 18 years and more were collected and the patients were grouped according to forced expiratory volume in 1 s (FEV1) as severe group:

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Could Hif-1∝ Be A Novel Biomarker For The Clinical Course And Treatment Of Pulmonary Embolism?, Buğra Kerget, Dursun Erol Afşi̇n, Alperen Aksakal, Alperen Aksakal, Seda Aşkin, Ömer Araz Jan 2020

Could Hif-1∝ Be A Novel Biomarker For The Clinical Course And Treatment Of Pulmonary Embolism?, Buğra Kerget, Dursun Erol Afşi̇n, Alperen Aksakal, Alperen Aksakal, Seda Aşkin, Ömer Araz

Turkish Journal of Medical Sciences

Background/aim: Pulmonary embolism (PE) is associated with high morbidity and mortality rates if not diagnosed and treated rapidly. The aim of our study was to investigate the relationship between levels of hypoxia-induced factor-1 alpha (HIF-1∝) and clinical course and prognosis in patients with intermediate low-risk, intermediate high-risk, and high-risk PE. Materials and methods: The study included 240 subjects in 4 groups: a healthy control group (n = 60, mean age = 60 ± 15.2, female/male = 30/30 ), intermediate low-risk PE group (n = 60, mean age = 60 ± 12,5, female/male = 27/33), intermediate high-risk PE group (n = …

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The Effect Of Sacrospinous Ligament Fixation During Vaginal Hysterectomy On Postoperative De Novo Stress Incontinence Occurrence: A Prospective Study With 2-Year Follow-Up, Eralp Başer, Kerem Doğa Seçki̇n, Pinar Kadi̇roğullari, Hüseyi̇n Kiyak Jan 2020

The Effect Of Sacrospinous Ligament Fixation During Vaginal Hysterectomy On Postoperative De Novo Stress Incontinence Occurrence: A Prospective Study With 2-Year Follow-Up, Eralp Başer, Kerem Doğa Seçki̇n, Pinar Kadi̇roğullari, Hüseyi̇n Kiyak

Turkish Journal of Medical Sciences

Background/aim: To investigate the risk of de novo stress urinary incontinence (SUI) occurrence in women who were treated for pelvic organ prolapse (POP) with sacrospinous ligament fixation (SSLF) in addition to vaginal hysterectomy (VAH) and antero-posterior colporrhaphy (CAP) over a 24-month follow-up period. Materials and methods: A prospective randomized study was designed. Women without occult or obvious SUI were randomized into either one of the study groups: Group 1: VAH + CAP, and Group 2: VAH + CAP + SSLF. Postoperatively, the patients were reevaluated for de novo SUI occurrence. Results: A total of 150 women were analyzed [G1 = …

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Neurotrophic Factors In Bipolar Disorders Patients With Manic Episode, Özgür Korhan Tunçel, Gökhan Sarisoy, Eda Çeti̇n, Ebru Kaynar Tunçel, Bi̇rşen Bi̇lgi̇ci̇, Arzu Karaustaoğlu Jan 2020

Neurotrophic Factors In Bipolar Disorders Patients With Manic Episode, Özgür Korhan Tunçel, Gökhan Sarisoy, Eda Çeti̇n, Ebru Kaynar Tunçel, Bi̇rşen Bi̇lgi̇ci̇, Arzu Karaustaoğlu

Turkish Journal of Medical Sciences

Background/aim: Neurotrophins are one of the most important molecule groups affecting cerebral neuroplasticity. The amount of evidence about the role of changes in neuroplasticity in the pathophysiology of bipolar disease is growing. Materials and methods: We measured serum levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), glial cell-line derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), fibroblast growth factor (FGF)-2, neuritin 1 (Nrn 1) in bipolar 1 manic episode patients (n = 45) and healthy control group. Results: When controlled for age, BMI and cortisol, it was found that the serum …

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Evaluation Of The Cardioprotective Effects Of Crystalloid Del Nido Cardioplegia Solution Via A Rapid And Accurate Cardiac Marker: Heart-Type Fatty Acid-Binding Protein, Mehmet Ki̇ri̇şci̇, Aydemi̇r Koçarslan, Duygun Altintaş Aykan, Fi̇li̇z Alkan Baylan, Adem Doğaner, Yavuz Orak Jan 2020

Evaluation Of The Cardioprotective Effects Of Crystalloid Del Nido Cardioplegia Solution Via A Rapid And Accurate Cardiac Marker: Heart-Type Fatty Acid-Binding Protein, Mehmet Ki̇ri̇şci̇, Aydemi̇r Koçarslan, Duygun Altintaş Aykan, Fi̇li̇z Alkan Baylan, Adem Doğaner, Yavuz Orak

Turkish Journal of Medical Sciences

Background/aim: Our aim in this study was to compare the efficacy and safety of crystalloid del Nido solution and cold blood cardioplegia solution on clinical and laboratory parameters. Materials and methods: Sixty patients who underwent elective coronary bypass operation between July 2019 and January 2020 were included in our study. Patients were divided into 2 groups of 30 patients using del Nido solution (DNS) and cold blood cardioplegia solution (CBCS), which were given for cardiac arrest. Demographic data, preoperative, postoperative 0th h, 6th h and 4th day creatine kinase myocardial band (CK-MB) and troponin I values were compared with a …

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Prospective Evaluation Of Vascular Changes In Acute Respiratory Infections In Children With Cystic Fibrosis, Gökçen Kartal Öztürk, Aykut Eşki̇, Fi̇gen Çelebi̇ Çeli̇k, Seçi̇l Conkar, Fi̇gen Gülen, Esen Demi̇r, Ahmet Keski̇noğlu Jan 2020

Prospective Evaluation Of Vascular Changes In Acute Respiratory Infections In Children With Cystic Fibrosis, Gökçen Kartal Öztürk, Aykut Eşki̇, Fi̇gen Çelebi̇ Çeli̇k, Seçi̇l Conkar, Fi̇gen Gülen, Esen Demi̇r, Ahmet Keski̇noğlu

Turkish Journal of Medical Sciences

Background/aim: Acute exacerbations and chronic inflammation are risk factors for cardiovascular disease (CVD) in cystic fibrosis (CF) patients. The aim of this study was to investigate the effects of acute exacerbation therapy on arterial stiffness in children with CF. Materials and methods: Augmentation index (Aix) and pulse wave velocity (PWV) were measured before and after treatment and 1 month after the end of treatment in patients with acute exacerbation. The relationship between hemodynamic measurements and c-reactive protein (CRP) and pulmonary function tests (PFTs) was investigated. Results: Measurements before and after treatment were evaluated in 27 patients and were repeated in …

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Dti-Mri Findings In Synthetic Cannabinoid Users, Fatma Di̇lek Gökharman, Sonay Aydin, Sali̇h Ci̇hat Paltun, Erdem Fati̇hoğlu, Şafak Yalçin Şahi̇ner, Pinar Nerci̇s Koşar Jan 2020

Dti-Mri Findings In Synthetic Cannabinoid Users, Fatma Di̇lek Gökharman, Sonay Aydin, Sali̇h Ci̇hat Paltun, Erdem Fati̇hoğlu, Şafak Yalçin Şahi̇ner, Pinar Nerci̇s Koşar

Turkish Journal of Medical Sciences

Background/aim: Synthetic cannabinoids (SCs) are full agonists of both cannabinoid receptors. Conventional magnetic resonance imaging (MRI) findings of SC users are mainly defined as diffusion restriction and T2/FLAIR hyperintensity. Diffusion tensor imaging (DTI) studies examining SC users have shown contradictory results. The aim of this study was to define white matter (WM) changes of SC users using DTI. Materials and methods: The study included 22 patients with a history of using SC for 5-37 months, and 22 healthy, age and sex- matched control subjects. A total of 41 diffusion gradient directions were used in the acquisition of diffusion imaging data. …

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Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo Jan 2020

Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo

Turkish Journal of Medical Sciences

Background/aim: We aimed to explore the roles of glycoprotein glycosylation in the pathogenesis of Kashin-Beck disease (KBD), and evaluated the effectiveness of sodium hyaluronate treatment. Materials and methods: Blood and saliva were collected from KBD patients before and after the injection of sodium hyaluronate. Normal healthy subjects were included as controls. Saliva and serum lectin microarrays and saliva and serum microarray verifications were used to screen and confirm the differences in lectin levels among the three groups. Results: In saliva lectin microarray, bindings to Sophora japonica agglutinin (SJA), Griffonia (Bandeiraea) simplicifolia lectin I (GSL-I), Euonymus europaeus lectin (EEL), Maackia amurensis …

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The Relationship Of The Immune Response Mediator Genes' Polymorphic Variants With The Methotrexate Efficacy In Juvenile Idiopathic Arthritis, Liliia Nazarova, Ksenia Danilko, Viktor Malievsky, Denis Karimov, Akhat Bakirov, Tatiana Viktorova Jan 2020

The Relationship Of The Immune Response Mediator Genes' Polymorphic Variants With The Methotrexate Efficacy In Juvenile Idiopathic Arthritis, Liliia Nazarova, Ksenia Danilko, Viktor Malievsky, Denis Karimov, Akhat Bakirov, Tatiana Viktorova

Turkish Journal of Medical Sciences

Background/aim: The aim of the study was to analyze the relationship of the immune response mediator genes' polymorphic loci (TNFA rs1800629, LTA rs909253, IL1B rs16944, IL2-IL21 rs6822844, IL2RA rs2104286, IL6 rs1800795, IL10 rs1800872, MIF rs755622, CTLA4 rs3087243, NFKB1 rs28362491, PTPN22 rs2476601, PADI4 rs2240336) variants with the methotrexate efficacy in juvenile idiopathic arthritis (JIA). Materials and methods: The study included 274 JIA patients from the Republic of Bashkortostan, Russia. Achieving the American College of Rheumatology Pediatric 30 (ACR Pedi 30) response was regarded as the presence of the response to methotrexate (otherwise, as the absence), while achieving clinical remission on medication …

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Changes In P1 Latencies Of Children With Normal Hearing And Those With Cochlear Implants, Emre Eski̇ci̇oğlu, Günay Kirkim, Selhan Gürkan, Serpi̇l Mungan Durankaya, Tahsi̇n Oğuz Başokçu, Eni̇s Alpi̇n Güneri̇ Jan 2020

Changes In P1 Latencies Of Children With Normal Hearing And Those With Cochlear Implants, Emre Eski̇ci̇oğlu, Günay Kirkim, Selhan Gürkan, Serpi̇l Mungan Durankaya, Tahsi̇n Oğuz Başokçu, Eni̇s Alpi̇n Güneri̇

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to determine the age-related latency interval of P1 latencies of children with normal hearing, and to evaluate the P1 latency changes after surgery in children who underwent cochlear implantation. Materials and methods: We evaluated 60 children with normal hearing and 16 children with cochlear implants aged 0-6 years using cortical auditory evoked potentials. P1 latencies were measured only once in the children with normal hearing, and on the postoperative first day, and the first, third, and sixth postoperative months in the children with cochlear implants. Results: There was a statistically significant decrease in …

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Neuroprotective Effects Of Quercetin On Cerebral Vasospasm Following Experimental Subarachnoid Haemorrhage In Rats, Şanser Gül, Evren Aydoğmuş, Burak Bahadir, Mustafa Çağatay Büyükuysal, Berrak Güven Jan 2020

Neuroprotective Effects Of Quercetin On Cerebral Vasospasm Following Experimental Subarachnoid Haemorrhage In Rats, Şanser Gül, Evren Aydoğmuş, Burak Bahadir, Mustafa Çağatay Büyükuysal, Berrak Güven

Turkish Journal of Medical Sciences

Background/aim: We examined the protective effects of the natural flavonoid, quercetin, against cerebral vasospasm in an experimental rat subarachnoid haemorrhage (SAH) model. Materials and methods: Thirty-eight albino Wistar rats were divided into five groups as follows: group 1 (G1, n=8), no experimental intervention; group 2 (G2, n=8), subarachnoid physiological saline; group 3 (G3, n=8), SAH; group 4 (G4, n=7) SAH and low-dose (10 mg/kg) quercetin treatment; group 5 (G5, n=7), SAH and high-dose (50 mg/kg) quercetin treatment. Subarachnoid haemorrhage was induced by injection of 0.15 cc of autologous blood taken from the tail artery into the cisterna magna from the …

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The Effect Of Rituximab On Encapsulated Peritoneal Sclerosis In An Experimental Rat Model, Süleyman Karaköse, Ayşe Zeynep Bal, Eylem Pinar Eser, Murat Duranay Jan 2020

The Effect Of Rituximab On Encapsulated Peritoneal Sclerosis In An Experimental Rat Model, Süleyman Karaköse, Ayşe Zeynep Bal, Eylem Pinar Eser, Murat Duranay

Turkish Journal of Medical Sciences

Background/aim: Peritoneal sclerosis may be observed in varied manifestations. However, the most serious form is the encapsulated peritoneal sclerosis. We researched the effect of rituximab on peritoneal fibrosis in an experimental rat model. Materials and methods: Twenty-four Wistar Albino rats were divided into 4 equal groups. During weeks 0-3; group I received isotonic saline (IS) solution, group II, group III, and group IV received chlorhexidine gluconate (CG) via intraperitoneal (i.p.) route. In the next 3 weeks nothing adminestred to both group I and group II but IS solution was adminestred to group III via i.p. route and 375 mg/m2/ week …

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Analysing The Blood-Stemming Effect Of Ankaferd Blood Stopper In Medulla Spinalis Surgery, Dursun Turkoz, Cem Demi̇rel, Hüseyi̇n Sataloğlu, Cengiz Cokluk Jan 2020

Analysing The Blood-Stemming Effect Of Ankaferd Blood Stopper In Medulla Spinalis Surgery, Dursun Turkoz, Cem Demi̇rel, Hüseyi̇n Sataloğlu, Cengiz Cokluk

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the possible toxicity of the Ankaferd Blood Stopper (ABS) on the neural system. Materials and methods: Thirty Sprague Dawley rats were randomized into ABS (n: 15) and control (n: 15) groups. Following the anaesthetic induction, total laminectomy was performed to the lower thoracic, and upper lumbar areas in both groups and medulla spinalis was exposed. Two myelotomies were performed on the medulla spinalis. One millilitre ABS was applied to the incision site in the ABS group, and one millilitre 0.9% saline solution was applied in the control group. Rats were observed …

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Reply To Letter To The Editor, Zehra İpek Arslan Aydin Jan 2020

Reply To Letter To The Editor, Zehra İpek Arslan Aydin

Turkish Journal of Medical Sciences

No abstract provided.

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Investigation The Potential Use Of Silver Nanoparticles Synthesized By Propolis Extract As N-Acyl-Homoserine Lactone-Mediated Quorum Sensing Systems Inhibitor, Sedef İlk, Gamze Tan, Ezgi̇ Emül, Necdet Sağlam Jan 2020

Investigation The Potential Use Of Silver Nanoparticles Synthesized By Propolis Extract As N-Acyl-Homoserine Lactone-Mediated Quorum Sensing Systems Inhibitor, Sedef İlk, Gamze Tan, Ezgi̇ Emül, Necdet Sağlam

Turkish Journal of Medical Sciences

Background/aim: Quorum sensing (QS) is a chemical communication process that bacteria use to regulate virulence. Inhibition of QS (antiQS) overcomes the pathogenicity of bacteria. Silver nanoparticles (AgNPs) have been used as antimicrobials against pathogens, but have not been used against QS-mediated bacterial infection. Also, studies have been carried out on the inhibitory effects of propolis based structures on pathogen growth, but no studies have been found on their potential use as QS inhibitor. The present study aims to investigate the synthesis and characterization of silver nanoparticles (AgNPs) reduced with propolis extract (P-AgNPs) and evaluation of their antimicrobial and, for the …

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Baicalein Nanofiber Scaffold Containing Hyaluronic Acid And Polyvinyl Alcohol: Preparation And Evaluation, Kamel Bachimam, Ezgi̇ Emül, Necdet Sağlam, Feza Korkusuz Jan 2020

Baicalein Nanofiber Scaffold Containing Hyaluronic Acid And Polyvinyl Alcohol: Preparation And Evaluation, Kamel Bachimam, Ezgi̇ Emül, Necdet Sağlam, Feza Korkusuz

Turkish Journal of Medical Sciences

Background/aim: Bone tumor is one of the major causes of tissue bone loss, particularly after performing surgical excision operation to bone lesion that needs to be replaced by biomaterials and ensure a complete filling of tissue-loss spaces. The purpose of our study was to produce a nanofiber-based bone graft scaffold to fill the gaps resulted from bone cancer treatment and also capable of carrying functional molecules that can play a major role in preventing further cancer growth at the targeted bone tissue. Materials and methods: Electrospinning method was used in order to produce nanofibers from different kinds of polymers; Hyaluronic …

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A Novel Urethra Compression Technique Using Turkish Continence Device For Male Urinary Incontinence, Öner Odabaş, İrem Gül Sancak, Yusuf Kasap, Zerri̇n Mahmut, Erkan Ölçücüoğlu, Sedat Taştemur, Nesli̇han İnci̇ Zengi̇n Jan 2020

A Novel Urethra Compression Technique Using Turkish Continence Device For Male Urinary Incontinence, Öner Odabaş, İrem Gül Sancak, Yusuf Kasap, Zerri̇n Mahmut, Erkan Ölçücüoğlu, Sedat Taştemur, Nesli̇han İnci̇ Zengi̇n

Turkish Journal of Medical Sciences

Background/aim: The male sling operation and artificial urinary sphincter implantation are common methods for treating urinary incontinence. However, there are some drawbacks to these methods such as infection, urethral erosion, pain, inefficiency, and the technical difficulty of the operations. Here we describe a new device we have named the Turkish Continence Device (TCD) which has advantages over these other methods. The aim of this study was perform experiments with the TCD prototype in vivo and ex vivo to determine efficiency, convenience of implantation, and negative effects.Materials and methods: We implanted the prototype device in male goats and sheep, compressing the …

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Value Of Prognostic Scores In Antineutrophil Cytoplasmic Antibody (Anca) Associated Vasculitis Patients In Intensive Care Unit: A Multicenter Retrospective Cohort Study From Turkey, Uğur Özdemi̇r, Nazmi̇ye Ebru Ortaç Ersoy, Recep Ci̇van Yüksel, Erhan Kaya, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu, Arzu Topeli̇ İski̇t, Muhammet Güven, Murat Sungur, Neri̇man Defne Altintaş Jan 2020

Value Of Prognostic Scores In Antineutrophil Cytoplasmic Antibody (Anca) Associated Vasculitis Patients In Intensive Care Unit: A Multicenter Retrospective Cohort Study From Turkey, Uğur Özdemi̇r, Nazmi̇ye Ebru Ortaç Ersoy, Recep Ci̇van Yüksel, Erhan Kaya, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu, Arzu Topeli̇ İski̇t, Muhammet Güven, Murat Sungur, Neri̇man Defne Altintaş

Turkish Journal of Medical Sciences

Background/aim: There is a need for a scoring system for predicting ICU prognosis of patients with ANCA-associated vasculitis (AAV), but there are limited data on it in the literature. Therefore, we aimed to determine the scores that can estimate the prognosis of patients with AAV during intensive care follow up.Materials and methods: All adult patients admitted to the medical ICUs of 4 reference university hospitals in Turkey due to AAV activation and/or disease/treatment complications in the last 10 years were included in this study. Demographic data, treatments before ICU, the Birmingham Vasculitis Activity Score (BVAS) score at the time of …

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Effect Of Sugammadex On Chest Radiographic Abnormality In The Early Postoperative Period After Video-Assisted Thoracoscopic Lobectomy, Dong Kyu Lee, Sung Wook Kang, Hyun Koo Kim, Hyo Sung Kim, Heezoo Kim Jan 2020

Effect Of Sugammadex On Chest Radiographic Abnormality In The Early Postoperative Period After Video-Assisted Thoracoscopic Lobectomy, Dong Kyu Lee, Sung Wook Kang, Hyun Koo Kim, Hyo Sung Kim, Heezoo Kim

Turkish Journal of Medical Sciences

Background/aim: Sugammadex, which offsets the effects of neuromuscular blocking agents (NMBs), has advantages over traditional reversal agents like pyridostigmine, as it enables fast and reliable recovery from neuromuscular blockade. This study compared the incidence of early postoperative chest radiographic abnormalities (CRA) between sugammadex (group S) and pyridostigmine (group P) following video-assisted thoracoscopic (VAT) lobectomy for lung cancer.Materials and methods: We performed a retrospective cohort analysis by reviewing the medical records of patients who underwent VAT lobectomy at a single university medical center. We defined the early postoperative CRA as a characteristic appearance on chest radiograph up to 2 days after …

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Alterations In Follicular Fluid Bmp-15 Rna Expression In Women Undergoing Controlled Ovarian Hyperstimulation, Şükri̇ye Derya Deveci̇ Jan 2020

Alterations In Follicular Fluid Bmp-15 Rna Expression In Women Undergoing Controlled Ovarian Hyperstimulation, Şükri̇ye Derya Deveci̇

Turkish Journal of Medical Sciences

Background/aim: Bone morphogenetic protein-15 (BMP-15) is one of the maturation indicators of the ovarian follicular pool. The aim of this study was to investigate the possible difference of follicular fluid (FF) BMP-15 RNA expression among low, normal, and high responder women attending controlled ovarian hyperstimulation-intracytoplasmic sperm injection (COH-ICSI) cycles.Materials and methods: This cross-sectional study was conducted with 75 FFs of COH-ICSI cycles performed at the IVF Unit of University Hospital. Twenty FF from low response (group 1), 27 FF from normal response (group 2), and 28 FF from high response (group 3) were recruited for the study between September 2014 …

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Statistical Shape Analysis Of Hand And Wrist In Paediatric Population On Radiographs, Ural Koç, İlker Ercan, Senem Özdemi̇r, Semi̇h Bolu, Ayşegül Yabaci, Onur Taydaş Jan 2020

Statistical Shape Analysis Of Hand And Wrist In Paediatric Population On Radiographs, Ural Koç, İlker Ercan, Senem Özdemi̇r, Semi̇h Bolu, Ayşegül Yabaci, Onur Taydaş

Turkish Journal of Medical Sciences

Background/aim: The goal of this study was to compare differences in hand and wrist shapes and to evaluate these according to growth and allometry in children on radiographs related to bone age.Materials and methods: The study included 263 males and 189 females. A total of 452 left hand and wrist radiographs were retrospectively collected. Standard anatomical landmarks marked on radiographs.Results: There were seen to be significant differences in comparisons of hand and wrist shapes according to sex (P = 0.009). The most suitable model in the growth models was seen as the Gompertz growth model for both females and males …

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He Utility Of Synovial Fluid Levels Of Adamts9 And Adamts4 In Predicting Treatment Responses To Intraarticular Steroid Injections In Patients With Knee Osteoarthritis, Kenan Özler Jan 2020

He Utility Of Synovial Fluid Levels Of Adamts9 And Adamts4 In Predicting Treatment Responses To Intraarticular Steroid Injections In Patients With Knee Osteoarthritis, Kenan Özler

Turkish Journal of Medical Sciences

Background/aim: This study aims to identify the role of synovial fluid levels of a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) and a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) for the prediction of intraarticular steroid injection success in knee osteoarthritis (OA).Material and methods: A total of eighty-four advanced stage knee OA patients (42 with stage 3 OA and 42 with stage 4 OA) were enrolled in the study. Baseline and posttreatment outcomes were determined using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Pretreatment synovial fluid ADAMTS9 and ADAMTS4 levels were measured by enzyme linked immunosorbent assay …

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Presence Of Paroxysmal Nocturnal Hemoglobinuria In Patients With Idiopathic Portal Vein Thrombosis: A Single-Center Study, Cengi̇z Demi̇r, Senar Ebi̇nç, Ömer Eki̇nci̇ Jan 2020

Presence Of Paroxysmal Nocturnal Hemoglobinuria In Patients With Idiopathic Portal Vein Thrombosis: A Single-Center Study, Cengi̇z Demi̇r, Senar Ebi̇nç, Ömer Eki̇nci̇

Turkish Journal of Medical Sciences

Background/aim: Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare clonal hematopoietic stem cell disease characterized by chronic hemolytic anemia and thrombosis. We report data from a study of the occurrence of PNH among patients with idiopathic portal vein thrombosis (PVT). Materials and methods: Patients who were followed up with the diagnosis of idiopathic PVT were enrolled into this study. Those with laboratory and/or imaging evidence of any local or systemic factor that could lead to PVT were excluded. PNH clone was examined in all patients using established FLAER methodology.Results: A total of 112 patients (42 males and 70 females), none …

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Correlation Of Language Lateralization With Resting State Hippocampal Connectivity In Temporal Lobe Epilepsy Patients, Ali̇ Murat Koç, Ali̇ Yusuf Öner, Hali̇l Özer, Meli̇ke Güryildirim, Emi̇n Turgut Tali, Fati̇h Öncü, Murat Uçar, Erhan Bi̇li̇r, İrem Çapraz, Gökhan Kurt Jan 2020

Correlation Of Language Lateralization With Resting State Hippocampal Connectivity In Temporal Lobe Epilepsy Patients, Ali̇ Murat Koç, Ali̇ Yusuf Öner, Hali̇l Özer, Meli̇ke Güryildirim, Emi̇n Turgut Tali, Fati̇h Öncü, Murat Uçar, Erhan Bi̇li̇r, İrem Çapraz, Gökhan Kurt

Turkish Journal of Medical Sciences

Background/aim: The main purpose of this study is to evaluate the resting state hippocampal connectivity with language areas and to correlate them with laterality index calculations on single subject basis, hence to present hippocampal lateralization for language with rs-fMRI.Materials and methods: Task based and rs-fMRI data were gathered from a total of 45 subjects in 3T scanner. BrainVoyager QX, SPM, and CONN softwares were used for data analysis. LI score of each subject was calculated and converted into normalized LI score (nLI). Intrahemispheric rs-connectivity analysis was performed between hippocampus and Broca's regions on both sides. Correlation between these variables was …

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Antioxidant Effects Of Dexmedetomidine Against Hydrogen Peroxide-Induced Dna Damage In Vitro By Alkaline Comet Assay, Mustafa Sirri Kotanoğlu, Ela Kadioğlu, Esra Emerce, Çeti̇n Kaymak, Ayşe Özcan, Hülya Başar Jan 2020

Antioxidant Effects Of Dexmedetomidine Against Hydrogen Peroxide-Induced Dna Damage In Vitro By Alkaline Comet Assay, Mustafa Sirri Kotanoğlu, Ela Kadioğlu, Esra Emerce, Çeti̇n Kaymak, Ayşe Özcan, Hülya Başar

Turkish Journal of Medical Sciences

Background/aim: Dexmedetomidine (DEX) is an alpha-2 adrenergic agonist that is commonly used as a sedative and anesthetic. The protective effects of DEX against oxidative damage under both in vitro and in vivo conditions have been demonstrated. It was aimed to evaluate and compare the protective effects of DEX and vitamin C (Vit C) on DNA against H2O2-induced DNA damage in human lymphocyte cell cultures in vitro by alkaline Comet assay.Materials and methods: Lymphocyte cell cultures were divided into 5 groups, as the negative control, solvent control, positive control, hydrogen peroxide (H2O2; 150 µM) + DEX (1 µM; 2.5 µM; 5 …

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What Is The Impact Of Ppar-? Agonist-Rosiglitazone On Ovarian Reserve After Hysterectomy? An Experimental Study, Burcu Gündoğdu Öztürk, Ömer Lütfi̇ Tapisiz, Berna Di̇lbaz, Serkan Bariş Mülazimoğlu, Kami̇l Hakan Müftüoğlu, Betül Dündar, Ümi̇t Göktolga Jan 2020

What Is The Impact Of Ppar-? Agonist-Rosiglitazone On Ovarian Reserve After Hysterectomy? An Experimental Study, Burcu Gündoğdu Öztürk, Ömer Lütfi̇ Tapisiz, Berna Di̇lbaz, Serkan Bariş Mülazimoğlu, Kami̇l Hakan Müftüoğlu, Betül Dündar, Ümi̇t Göktolga

Turkish Journal of Medical Sciences

Background/aim: To evaluate the effects of hysterectomy on rat ovaries and the possible protective role of peroxisome proliferator-activated receptor gamma (PPAR-?) agonist-rosiglitazone against ovarian reserve decrement.Materials and methods: Forty-five adult Wistar albino rats were randomly divided into three groups. Hysterectomy was performed (n = 15) in group 1 [H]; 1 mg/kg/day PPAR-? agonist/rosiglitazone was used for 50 days after hysterectomy (n = 15) in group 2 [H + R]; a sham operation was performed (n = 15) in group 3 [control, C]. Blood samples were collected for anti-Müllerian hormone (AMH) evaluation in all groups and simultaneous ovarian Doppler examination was …

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Assessment Of Ankaferd Blood Stopper In Experimental Liver Ischemia Reperfusion Injury, Abdullah Durhan, Koray Koşmaz, Marlen Süleyman, Mesut Tez, Abdullah Şenli̇kci̇, Can Ersak, Yilmaz Ünal, Mevlüt Recep Pekci̇ci̇, Fati̇h Karaahmet, Mehmet Şeneş, İlknur Alkan Kuşabbi̇, Eylem Pinar Eser, Sema Hücümenoğlu Jan 2020

Assessment Of Ankaferd Blood Stopper In Experimental Liver Ischemia Reperfusion Injury, Abdullah Durhan, Koray Koşmaz, Marlen Süleyman, Mesut Tez, Abdullah Şenli̇kci̇, Can Ersak, Yilmaz Ünal, Mevlüt Recep Pekci̇ci̇, Fati̇h Karaahmet, Mehmet Şeneş, İlknur Alkan Kuşabbi̇, Eylem Pinar Eser, Sema Hücümenoğlu

Turkish Journal of Medical Sciences

Background/aim: To investigate possible protective effects of Ankaferd Blood Stopper® (ABS) in an experimental liver ischemia reperfusion injury (IRI) model. Materials and methods: The study was carried out on 30 female rats separated into 3 groups as sham, control (IRI), and treatment (IRI + ABS) groups. In the IRI + ABS group, 0.5 mL/day ABS was given for 7 days before surgery. In the IRI and IRI + ABS groups, the hepatic pedicle was clamped for 30 min to apply ischemia. Then, after opening the clamp, 90-min reperfusion of the liver was provided. Blood and liver tissue samples were taken …

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Antiinfective And Wound-Healing Pleiotropic Actions Of Ankaferd Hemostat, İbrahi̇m Celaletti̇n Haznedaroğlu, Mustafa Çelebi̇er Jan 2020

Antiinfective And Wound-Healing Pleiotropic Actions Of Ankaferd Hemostat, İbrahi̇m Celaletti̇n Haznedaroğlu, Mustafa Çelebi̇er

Turkish Journal of Medical Sciences

To the Editor,We read with great interest the article entitled "An evaluation of the effects of caffeic acid phenethyl ester and Ankaferd blood stopper on secondary wound healing of oral mucosal tissue", published recently in the Journal[1]. The authors indicated that Ankaferd Hemostat (Ankaferd Blood Stopper, ABS) and caffeic acid phenethyl ester had positive effects on the oral wound healing process. Since ABS has already been used in dental surgery for years, it is known as not irritable to the oral mucosa [2]. ABS antibacterial, antiinfective, and cellular features are also established [3]. More importantly, ABS is clinically effective in …

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