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Articles 155851 - 155880 of 325435
Full-Text Articles in Medicine and Health Sciences
Can School Be A Source Of Trauma? Assessing Academic Traumatic Stress As A Mechanism Underlying The Health Outcomes Of Black Undergraduate Students, Ebony A. Lambert
Can School Be A Source Of Trauma? Assessing Academic Traumatic Stress As A Mechanism Underlying The Health Outcomes Of Black Undergraduate Students, Ebony A. Lambert
Theses and Dissertations
Research examining Black students’ school experiences demonstrates that exposure to oppressive power dynamics in schools may lead to adverse physiological and psychological consequences. Recent conceptualizations in public discourse further posit that traumatic educational experiences, operationalized here as academic trauma or the cumulative toll of adverse and oppressive experiences in academic settings, may influence Black students’ wellbeing even after they have graduated. However, academic trauma has yet to be investigated empirically, and the health contributions of such educational harm remain unstudied. Moreover, little is known about how culturally-relevant personal characteristics (e.g., emotion regulation strategies) influence Black students’ reactivity to academic trauma. …
Impact Of Performance-Based Budgeting On Quality Outcomes In U.S. Military Healthcare Facilities, Kimberly L. Decker Virginia Commonwealth University
Impact Of Performance-Based Budgeting On Quality Outcomes In U.S. Military Healthcare Facilities, Kimberly L. Decker Virginia Commonwealth University
Theses and Dissertations
Performance-based budgeting (PBB) is a variation of pay for performance that is applicable to government programs. It works by increasing or decreasing funding based on pre-established performance thresholds, which incentivizes organizations to improve performance. In late 2006, the U.S. Army implemented a PBB program in all of its healthcare facilities due to rising concerns over costs and quality in its facilities. The U.S. Army’s PBB program tied hospital-level funding decisions to performance on key cost and quality-related metrics. This study examined the impact of this program and a subsequent PBB program on quality improvement in U.S. Army healthcare facilities. Drawing …
Hospital Investment In Urgent Care: Impacts On Emergent, Outpatient, And Ambulatory Surgery Volumes, Hillary A. Linhart
Hospital Investment In Urgent Care: Impacts On Emergent, Outpatient, And Ambulatory Surgery Volumes, Hillary A. Linhart
Theses and Dissertations
As the popularity of urgent care centers (UCCs) has grown, hospitals have increasingly chosen to invest in this care model. Hospital interest in UCCs is largely driven by two key factors. First, hospitals aim to use UCCs to generate referrals, which generate additional patient volume for downstream hospital services. Secondly, hospital UCC investment presents an opportunity to ease the demand for non-urgent care in the emergency department (ED) by diverting low-acuity ED patients to the more appropriate UCC setting. No study to date has evaluated the impact of hospital UCC investment on referrals or downstream service volumes. A few studies …
An Exploration In Accountable Care Organization Structure, Contingency And Performance, 2015-2017, Siriporn P. Satjapot
An Exploration In Accountable Care Organization Structure, Contingency And Performance, 2015-2017, Siriporn P. Satjapot
Theses and Dissertations
The Patient Protection and Affordable Care Act of 2010 enacted one of the most significant reforms seen in the United States healthcare landscape. The Center for Medicare and Medicaid (CMS) led transformation efforts in regulatory reform and coverage expansion across the U.S. population. Since 2010, care delivery systems have been shifting from episodic, decentralized and fee-for-service models to value-based population health models, like accountable care organizations (ACO). ACOs have been specifically primed for local response to improve the health of their communities. ACO research has traditionally focused on performance measures like mortality, readmissions, quality outcomes and savings. ACO organizational characteristics …
Spag17 Is Important For Protein Trafficking In Mammalian Spermiogenesis, Virali Bhagat
Spag17 Is Important For Protein Trafficking In Mammalian Spermiogenesis, Virali Bhagat
Theses and Dissertations
Spermiogenesis is the process through which undifferentiated germ cells develop into mature spermatozoa. While spermiogenesis is a very well-regulated process, the protein-protein interactions regulating it remain poorly understood. A knockout (KO) mouse for the ciliary protein SPAG17 was generated by our lab. Loss of SPAG17 has been shown to disrupt the transport of proteins important for acrosome biogenesis and manchette functions. With this information, we hypothesized that SPAG17 plays an essential role in protein trafficking during mammalian spermiogenesis. To further investigate this, immunofluorescence (IF) studies were performed in germ cells collected from both WT and SPAG17 KO mice to visualize …
Prediction Of The Vaginal Microbiome Using Urine Samples, Christopher R. Diachok
Prediction Of The Vaginal Microbiome Using Urine Samples, Christopher R. Diachok
Theses and Dissertations
The vaginal microbiome is associated with women’s health, including but not limited to the pathogenesis of bacterial vaginosis, adverse pregnancy outcomes including preterm birth and sexually transmitted infections. However, there has been very limited research on the urinary microbiome and its relationship to the vaginal microbiome. We sought to predict the vaginal microbiome profile using clean catch urine samples from the same person. Here, paired vaginal and urine samples were collected and sequenced by 16S ribosomal RNA sequencing. Alpha and beta diversity analysis showed that there was no significant difference between the paired vaginal and urine microbiomes. In fact, a …
Anticholinergic Burden And Risk Of Cognitive Impairment In Older Adults, Syeda Hashimi
Anticholinergic Burden And Risk Of Cognitive Impairment In Older Adults, Syeda Hashimi
Theses and Dissertations
Studies reveal that 10-27% of older adults chronically use anticholinergic medications. Increased cumulative anticholinergic burden scores are associated with increased risks of dementia. The mechanisms by which anticholinergic drugs negatively impact cognition remain elusive. However, researchers speculate that the drug’s impairment of cholinergic neurons promotes neuroinflammation.
We hypothesize that drugs with anticholinergic properties will induce inflammation in the brain. MCP1 and IL 6 are chemokines that contribute to neuroinflammation. We investigated the influence of diphenhydramine (Benadryl) on the production of MCP1 and IL-6 in Normal Human Astrocytes and Paroxetine on the production of MCP1 in Normal Human Astrocytes and Normal …
Advanced Preparation Makes Research In Emergencies And Isolation Care Possible: The Case Of Novel Coronavirus Disease (Covid-19), David Brett-Major, Elizabeth R. Schnaubelt, Hannah M. Creager, Abigail Lowe, Theodore J. Cieslak, Jacob M. Dahlke, Daniel W. Johnson, Paul D. Fey, Keith F. Hansen, Angela L. Hewlett, Bruce G. Gordon, Andre C. Kalil, Ali S. Khan, Mark G. Kortepeter, Christopher J. Kratochvil, Luann Larson, Deborah A. Levy, James Linder, Sharon J. Medcalf, Mark E. Rupp, Michelle M. Schwedhelm, James N. Sullivan Md, Angela M. Vasa, Michael C. Wadman, Rachel E. Lookadoo, John-Martin J. Lowe, James V. Lawler, M. Jana Broadhurst
Advanced Preparation Makes Research In Emergencies And Isolation Care Possible: The Case Of Novel Coronavirus Disease (Covid-19), David Brett-Major, Elizabeth R. Schnaubelt, Hannah M. Creager, Abigail Lowe, Theodore J. Cieslak, Jacob M. Dahlke, Daniel W. Johnson, Paul D. Fey, Keith F. Hansen, Angela L. Hewlett, Bruce G. Gordon, Andre C. Kalil, Ali S. Khan, Mark G. Kortepeter, Christopher J. Kratochvil, Luann Larson, Deborah A. Levy, James Linder, Sharon J. Medcalf, Mark E. Rupp, Michelle M. Schwedhelm, James N. Sullivan Md, Angela M. Vasa, Michael C. Wadman, Rachel E. Lookadoo, John-Martin J. Lowe, James V. Lawler, M. Jana Broadhurst
Journal Articles: Epidemiology
The optimal time to initiate research on emergencies is before they occur. However, timely initiation of high-quality research may launch during an emergency under the right conditions. These include an appropriate context, clarity in scientific aims, preexisting resources, strong operational and research structures that are facile, and good governance. Here, Nebraskan rapid research efforts early during the 2020 coronavirus disease pandemic, while participating in the first use of U.S. federal quarantine in 50 years, are described from these aspects, as the global experience with this severe emerging infection grew apace. The experience has lessons in purpose, structure, function, and performance …
Diagnostic Accuracy Of Chest Computed Tomography Scans For Suspected Patients With Covid-19: Receiver Operating Characteristic Curve Analysis, Lianpin Wu, Qike Jin, Jie Chen, Jiawei He, David Brett-Major, Jianghu James Dong
Diagnostic Accuracy Of Chest Computed Tomography Scans For Suspected Patients With Covid-19: Receiver Operating Characteristic Curve Analysis, Lianpin Wu, Qike Jin, Jie Chen, Jiawei He, David Brett-Major, Jianghu James Dong
Journal Articles: Epidemiology
BACKGROUND: Computed tomography (CT) scans are increasingly available in clinical care globally. They enable a rapid and detailed assessment of tissue and organ involvement in disease processes that are relevant to diagnosis and management, particularly in the context of the COVID-19 pandemic.
OBJECTIVE: The aim of this paper is to identify differences in the CT scan findings of patients who were COVID-19 positive (confirmed via nucleic acid testing) to patients who were confirmed COVID-19 negative.
METHODS: A retrospective cohort study was proposed to compare patient clinical characteristics and CT scan findings in suspected COVID-19 cases. A multivariable logistic model with …
The Impact Of Body Mass Index And Sociodemographic Factors On Moderate-To-Vigorous Physical Activity And Sedentary Behaviors Of Women With Young Children: A Cross-Sectional Examination, Danae M. Dinkel, Nicholas Hein, Kailey Snyder, Mohammad Siahpush, Shannon I. Maloney, Lynette M. Smith, Evi A. Farazi, Corrine K. Hanson
The Impact Of Body Mass Index And Sociodemographic Factors On Moderate-To-Vigorous Physical Activity And Sedentary Behaviors Of Women With Young Children: A Cross-Sectional Examination, Danae M. Dinkel, Nicholas Hein, Kailey Snyder, Mohammad Siahpush, Shannon I. Maloney, Lynette M. Smith, Evi A. Farazi, Corrine K. Hanson
Journal Articles: Epidemiology
OBJECTIVES: Moderate-to-vigorous physical activity provides multiple benefits to women after childbirth. To achieve these benefits, the recommendation that adults obtain, 150 min of moderate-to-vigorous physical activity per week and reduce sedentary behaviors, also applies to women in the post-partum phase of the life span. However, research examining the moderate-to-vigorous physical activity and sedentary behaviors of women with young children (0-2 years) is limited. A greater understanding of these behaviors from a nationally representative sample is needed. Therefore, the primary objective of this study was to determine the levels of moderate-to-vigorous physical activity and sedentary behaviors of a nationally representative sample …
The Covid-19 Response In Nebraska: How Students Answered The Call, Sabrine Chengane, Anlan Cheney, Sierra Garth, Sharon J. Medcalf
The Covid-19 Response In Nebraska: How Students Answered The Call, Sabrine Chengane, Anlan Cheney, Sierra Garth, Sharon J. Medcalf
Journal Articles: Epidemiology
The Student Response Team at the University of Nebraska Medical Center answered the statewide call to assist local health departments during the coronavirus disease 2019 (COVID-19) pandemic. As a voluntary student-led effort, the SRT assisted health departments to conduct contact tracing, monitor social media, and educate the public. Their experience demonstrates how students can increase the public health surge capacity of local health departments while gaining applied experience during public health emergencies. This call-to-action commentary proposes that SRTs should be formed, trained, and deployed through academic institutions across the nation and the globe, during and beyond the current pandemic.
Colorectal Cancer Screening Uptake: Differences Between Rural And Urban Privately-Insured Population, Mesnad Alyabsi, Jane L. Meza, K. M. Monirul Islam, Amr Soliman, Shinobu Watanabe-Galloway
Colorectal Cancer Screening Uptake: Differences Between Rural And Urban Privately-Insured Population, Mesnad Alyabsi, Jane L. Meza, K. M. Monirul Islam, Amr Soliman, Shinobu Watanabe-Galloway
Journal Articles: Epidemiology
Earlier studies investigated rural-urban colorectal cancer (CRC) screening disparities among older adults or used surveys. The objective was to compare screening uptake between rural and urban individuals 50-64 years of age using private health insurance. Data were analyzed from 58,774 Blue Cross Blue Shield of Nebraska beneficiaries. Logistic regression was used to assess the association between rural-urban and CRC screening use. Results indicate that rural individuals were 56% more likely to use the Fecal Occult Blood Test (FOBT) compared with urban residents, but rural females were 68% less likely to use FOBT. Individuals with few Primary Care Physician (PCP) visits …
การพัฒนาวิธี Real-Time Quantitative Rt-Pcrสำหรับตรวจหาลีดเดอร์อาร์เอ็นเอซับจีโนมิกของเชื้อไวรัส Sars-Cov-2, สินินาถ เพชราช
การพัฒนาวิธี Real-Time Quantitative Rt-Pcrสำหรับตรวจหาลีดเดอร์อาร์เอ็นเอซับจีโนมิกของเชื้อไวรัส Sars-Cov-2, สินินาถ เพชราช
Chulalongkorn University Theses and Dissertations (Chula ETD)
โรคอุบัติใหม่ไวรัสโคโรนา 2019 (COVID-19) เกิดจากการติดเชื้อ Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) โรคนี้ติดต่อกันได้ง่ายจากคนสู่คน ทำให้ไวรัสแพร่ระบาดอย่างต่อเนื่องไปทั่วโลก การตรวจติดตามและการประเมินไวรัสที่ปลดปล่อยเชื้อ (viral shedding) เป็นระยะเวลานานหลายสัปดาห์ จึงมีความสำคัญต่อการป้องกันและควบคุมการแพร่กระจายของเชื้อ ซึ่งเป็นอุปสรรคต่อการบริหารจัดการทางการแพทย์ รวมถึงมีค่าใช้จ่ายในการรักษาสูง ดังนั้นการตรวจพบ SARS-CoV-2 subgenomic RNA leader (sgRNA) เป็นตัวบ่งบอกสถานะของไวรัสในระยะ active มีความสามารถเพิ่มจำนวนได้ ในงานวิจัยนี้ได้ตรวจติดตามระยะเวลาการปลดปล่อย SARS-CoV-2 sgRNA leader และ genomic RNA (gRNA) จากตัวอย่างระบบทางเดินหายใจ 111 ตัวอย่าง (ของผู้ป่วย COVID-19 จำนวน 10 ราย) ด้วยวิธี real-time quantitative RT-PCR (qRT-PCR) ผลการทดลองพบว่า E-sgRNA leader สามารถตรวจพบได้นานถึง 15 วัน และตรวจพบในตัวอย่างที่มีปริมาณไวรัส (viral load) มากกว่า 100,000 copies/ml (≥1E+05 virus E gene copies/ml) ในขณะที่ gRNA ยังตรวจพบได้นานถึง 24 วัน นอกจากนี้ยังค้นพบว่ามีผู้ป่วย COVID-19 จำนวน 2 ใน 10 ราย ที่ E-sgRNA leader ปรากฏตัวอีกครั้งหลังจากที่ตรวจไม่พบแล้วเป็นเวลา 2 วัน ถึง 8 วัน ด้วยเหตุนี้เพื่อความปลอดภัย จึงแนะนำให้ผู้ป่วยกักตัวหรือแยกตัวอย่างน้อย 14 วันหลังจากได้รับอนุญาตให้กลับบ้าน ดังนั้นการประเมิน E-sgRNA leader เป็นประโยชน์ต่อการวางแผนการรักษาผู้ป่วยโรคติดเชื้อไวรัส COVID-19
ผลของการฝึกการรับรู้และตอบสนองที่ข้อต่อร่วมกับการออกกำลังกายแบบสั่นสะเทือนทั้งร่างกายต่อการทรงตัวและการทำงานของระบบประสาทกล้ามเนื้อในนักกีฬาที่มีภาวะข้อเท้าไม่มั่นคง, ณภัทร เครือทิวา
Chulalongkorn University Theses and Dissertations (Chula ETD)
เพื่อศึกษาและเปรียบเทียบผลของการฝึกการรับรู้และตอบสนองที่ข้อต่อร่วมกับการออกกำลังกายแบบสั่นสะเทือนทั้งร่างกายที่มีต่อความสามารถในการทรงตัวและการทำงานของระบบประสาทกล้ามเนื้อในนักกีฬาที่มีภาวะข้อเท้าไม่มั่นคง ผู้เข้าร่วมงานวิจัยเป็นนักกีฬาระดับมหาวิทยาลัย ทั้งเพศชายและหญิงที่มีภาวะข้อเท้าไม่มั่นคง จำนวน 52 คน มีอายุระหว่าง 18-27 ปี โดยผ่านการตรวจร่างกายและเกณฑ์การคัดเข้าก่อนเข้าร่วมงานวิจัย จากการตอบแบบสอบถามประเมินตนเอง CAIT ได้คะแนนน้อยกว่าหรือเท่ากับ 24 คะแนน โดยแบ่งผู้เข้าร่วมวิจัยออกเป็น 4 กลุ่มๆ ละ 13 คน ได้แก่ กลุ่มควบคุมที่ไม่ได้รับการฝึกการรับรู้และตอบสนองที่ข้อต่อร่วมกับการออกกำลังกายแบบสั่นสะเทือนทั้งร่างกาย (Control) กลุ่มทดลอง 1 ที่ได้รับการฝึกการรับรู้และตอบสนองที่ข้อต่อเพียงอย่างเดียว (PPT) กลุ่มทดลอง 2 ที่ได้รับการออกกำลังกายแบบสั่นสะเทือนทั้งร่างกายเพียงอย่างเดียว (WBV) และกลุ่มทดลอง 3 ที่ได้รับการฝึกการรับรู้และตอบสนองที่ข้อต่อร่วมกับการออกกำลังกายแบบสั่นสะเทือนทั้งร่างกายต่อเนื่องกัน (PPT+WBV) โดยกลุ่มทดลองทั้ง 3 กลุ่มได้รับโปรแกรมการฝึกที่กำหนด 3 ครั้งต่อสัปดาห์ เป็นระยะเวลา 6 สัปดาห์ ในช่วงการทดลองทุกกลุ่มจะได้รับการฝึกซ้อมทักษะตามปกติภายใต้การควบคุมดูแลของผู้ฝึกสอน ทำการเก็บรวบรวมข้อมูลก่อนและหลังการฝึก ได้แก่ ข้อมูลคุณลักษณะทั่วไป การทดสอบความสามารถในการทรงตัวขณะอยู่นิ่งโดยเครื่องไบโอเด็กซ์ (Biodex stability system) และการทรงตัวขณะเคลื่อนไหวโดยการทดสอบการทรงตัวตามแนวเส้นรูปดาว (Star excursion balance test) วัดการรับรู้ความรู้สึกที่ข้อต่อ (Joint position senses, JPS) วัดความแข็งแรงของกล้ามเนื้อข้อเท้า ทดสอบการทำงานของข้อเท้าโดยการกระโดดลงสู่พื้น (Time to stability, TTS) และฮอฟแมนรีเฟล็กซ์ (H-reflex) ที่กล้ามเนื้อน่องด้านใน (Soleus muscle) ผลการวิจัยพบว่า ในกลุ่มควบคุม ไม่พบความแตกต่างของทุกตัวแปรก่อนและหลังการทดสอบอย่างมีนัยสำคัญทางสถิติ (p>0.05) ขณะที่ทั้ง 3 กลุ่มทดลอง มีค่าเฉลี่ยความสามารถในการทรงตัวทั้งขณะอยู่นิ่ง เวลาที่ผู้ทดสอบอยู่นิ่งหลังจากที่กระโดดลงมาสู้พื้นด้วยขาข้างเดียว และค่าเฉลี่ยความสูงของ H-reflex ที่กล้ามเนื้อ Soleus ดีขึ้นอย่างมีนัยสำคัญทางสถิติ (p<0.05) ยกเว้นบางตัวแปรในกลุ่ม WBV ที่มีค่าความสามารถในการการรับรู้ตำแหน่งของข้อต่อที่ไม่เปลี่ยนแปลง (p>0.05) ส่วนกลุ่ม PPT ไม่พบความแตกต่างก่อนและหลังการฝึกอย่างมีนัยสำคัญทางสถิติ (p>0.05) ของค่าความแข็งแรงของกล้ามเนื้อข้อเท้าและความสามารถในการทรงตัวขณะเคลื่อนไหว และกลุ่ม PPT+WBV ไม่พบความแตกต่างของความแข็งแรงของกล้ามเนื้อข้อเท้าที่ก่อนและหลังการฝึกอย่างมีนัยสำคัญทางสถิติ (p …0.05)>
Demonstration Of Reciprocal Diurnal Variation In Human Serum T3 And Rt3 Concentration Demonstrated By Mass Spectrometric Analysis And Establishment Of Thyroid Hormone Reference Intervals., Qian Sun, Lívia Avallone, Brian Stolze, Katherine A Araque, Yesim Özarda, Jacqueline Jonklaas, Toral Parikh, Kerry Welsh, Likhona Masika, Steven J Soldin
Demonstration Of Reciprocal Diurnal Variation In Human Serum T3 And Rt3 Concentration Demonstrated By Mass Spectrometric Analysis And Establishment Of Thyroid Hormone Reference Intervals., Qian Sun, Lívia Avallone, Brian Stolze, Katherine A Araque, Yesim Özarda, Jacqueline Jonklaas, Toral Parikh, Kerry Welsh, Likhona Masika, Steven J Soldin
Articles, Abstracts, and Reports
Background: There has been a wide range of reference intervals proposed in previous literature for thyroid hormones due to large between-assay variability of immunoassays, as well as lack of correction for collection time. We provided the diurnal reference intervals for five thyroid hormones, namely total thyroxine (TT4), total triiodothyronine (TT3), free thyroxine (FT4), free triiodothyronine (FT3), and reverse T3 (rT3), measured in serum samples of healthy participants using a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method.
Methods: Couplet serum samples (a.m. and p.m.) were collected from 110 healthy females and 49 healthy males. Healthy volunteers were recruited from four participating centers …
Intravascular Lymphoma With Progressive Cns Hemorrhage And Multiple Dissections., Ricky Chen, Gurjeet Singh, J Scott Mcnally, Cheryl A Palmer, Adam De Havenon
Intravascular Lymphoma With Progressive Cns Hemorrhage And Multiple Dissections., Ricky Chen, Gurjeet Singh, J Scott Mcnally, Cheryl A Palmer, Adam De Havenon
Articles, Abstracts, and Reports
Introduction: Intravascular lymphoma (IVL) is an uncommon and often fatal disease characterized by intraluminal proliferation of lymphomatous cells within blood vessels. Because of a heterogeneous clinical presentation and lack of sensitive diagnostic protocols, diagnosis of IVL is most often made at autopsy. However, with early diagnosis and appropriate chemotherapy, the prognosis is greatly improved and complete remission is possible. In order to broaden the possible presentations of IVL, we present a patient with an atypical manifestation of biopsy-proven intravascular large B-cell lymphoma who suffered dissections of both intracranial and extracranial arteries in addition to progressive intracranial hemorrhages.
Conclusion: IVL is …
Myd88 Regulates A Prolonged Adaptation Response To Environmental Dust Exposure-Induced Lung Disease, Amber N. Johnson, Jack R. Harkema, Amy J. Nelson, John D. Dickinson, Julianna Kalil, Michael J. Duryee, Geoffrey M. Thiele, Balawant Kumar, Amar B. Singh, Rohit Gaurav, Sarah C. Glover, Ying Tang, Debra J. Romberger, Tammy Kielian, Jill A. Poole
Myd88 Regulates A Prolonged Adaptation Response To Environmental Dust Exposure-Induced Lung Disease, Amber N. Johnson, Jack R. Harkema, Amy J. Nelson, John D. Dickinson, Julianna Kalil, Michael J. Duryee, Geoffrey M. Thiele, Balawant Kumar, Amar B. Singh, Rohit Gaurav, Sarah C. Glover, Ying Tang, Debra J. Romberger, Tammy Kielian, Jill A. Poole
Journal Articles: Internal Medicine
BACKGROUND: Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor protein myeloid differentiation factor88 (MyD88) is fundamental in regulating acute inflammatory responses to organic dust extract (ODE), yet its role in repetitive exposures is unknown and could inform future strategies.
METHODS: Wild-type (WT) and MyD88 knockout (KO) mice were exposed intranasally to ODE or saline daily for 3 weeks (repetitive exposure). Repetitively exposed animals were also subsequently rested with no treatments for 4 weeks followed by single rechallenge with saline/ODE.
RESULTS: Repetitive …
Heightened Levels Of Antimicrobial Response Factors In Patients With Rheumatoid Arthritis, Prathapan Ayyappan, Robert Z. Harms, Jennifer A. Seifert, Elizabeth A. Bemis, Marie L. Feser, Kevin D. Deane, M Kristen Demoruelle, Ted R. Mikuls, V Michael Holers, Nora Sarvetnick
Heightened Levels Of Antimicrobial Response Factors In Patients With Rheumatoid Arthritis, Prathapan Ayyappan, Robert Z. Harms, Jennifer A. Seifert, Elizabeth A. Bemis, Marie L. Feser, Kevin D. Deane, M Kristen Demoruelle, Ted R. Mikuls, V Michael Holers, Nora Sarvetnick
Journal Articles: Surgery
Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease leading to considerable disability over time. The disease can be characterized by the presence of multiple autoantibodies in the serum and synovial fluid. Microbial dysbiosis is proposed to play a role in the pathogenesis of RA. Increased systemic bacterial exposure leads to elevated levels of antimicrobial response factors (ARFs) in the circulation. In the present study, we tested whether RA patients have increased levels of ARFs by analyzing the levels of multiple ARFs in serum from RA patients and healthy age and sex-matched controls. The levels of soluble CD14 (sCD14), lysozyme, …
Age-Related Visual Dynamics In Hiv-Infected Adults With Cognitive Impairment., Boman R. Groff, Alex I. Wiesman, Michael T. Rezich, Jennifer O'Neill, Kevin R. Robertson, Howard S. Fox, Susan Swindells, Tony W. Wilson
Age-Related Visual Dynamics In Hiv-Infected Adults With Cognitive Impairment., Boman R. Groff, Alex I. Wiesman, Michael T. Rezich, Jennifer O'Neill, Kevin R. Robertson, Howard S. Fox, Susan Swindells, Tony W. Wilson
Journal Articles: Internal Medicine
OBJECTIVE: To investigate whether aging differentially affects neural activity serving visuospatial processing in a large functional neuroimaging study of HIV-infected participants and to determine whether such aging effects are attributable to differences in the duration of HIV infection.
METHODS: A total of 170 participants, including 93 uninfected controls and 77 HIV-infected participants, underwent neuropsychological assessment followed by neuroimaging with magnetoencephalography (MEG). Time-frequency analysis of the MEG data followed by advanced image reconstruction of neural oscillatory activity and whole-brain statistical analyses were used to examine interactions between age, HIV infection, and cognitive status. Post hoc testing for a mediation effect of …
Innovative Framework For Academic And Public Health Departments' Partnership On Preparing Future Practitioners- Preliminary Data, Michele Kekeh, Muge Akpinar-Elci, Myngoc Nguyen, Nancy Welch
Innovative Framework For Academic And Public Health Departments' Partnership On Preparing Future Practitioners- Preliminary Data, Michele Kekeh, Muge Akpinar-Elci, Myngoc Nguyen, Nancy Welch
Community & Environmental Health Faculty Publications
This article presents a model to respond to current public health challenges and transform knowledge into preventive strategies. It also presents an innovative way for academic institutes and public health departments to focus on public health workforce development. Academic institutes partnership with public health departments have started fostering service-learning opportunities to engage students in public health with an emphasis on the specific public health outcomes. However, the benefit of service–learning projects on the health departments and the populations served is largely unknown. Recently, these service-learning opportunities are becoming less sustainable due to the inability of preceptors to provide the necessary …
Anemia And It's Associated Factors Among Adolescents In Kuwait, Lemia Shaban, Abdullah Al-Taiar, Abdur Rahman, Reem Al-Sabah, Olusegun Mojiminiyi
Anemia And It's Associated Factors Among Adolescents In Kuwait, Lemia Shaban, Abdullah Al-Taiar, Abdur Rahman, Reem Al-Sabah, Olusegun Mojiminiyi
Community & Environmental Health Faculty Publications
We estimated the prevalence of anemia among school children and investigated factors associated with this problem in Kuwait. A cross-sectional study was conducted on 1415 adolescents randomly selected from middle schools in Kuwait. Hemoglobin, iron, ferritin, folate and vitamin B-12, in addition to many other laboratory indicators, were measured in a venous blood sample. Data on risk factors for anemia were collected from parents and adolescents. Multiple logistic regression was used to investigate factors associated with anemia. The prevalence of anemia was 8.06% (95% CI: 6.69-9.60%), which was significantly higher among females compared to males (10.96% vs. 5.04%; p < 0.001). Mean (SD) Hb level was 133.7 (9.89) g/L and 130.00 (10.48) g/L among males and females, respectively (p < 0.001). The prevalence of mild, moderate and severe anemia was 5.94%, 1.91% and 0.21%, respectively. Gender, age, iron concentration and ferritin were associated with anemia in multivariable analysis. These data indicate that anemia among school children in Kuwait is of mild public health significance. Further reduction in anemia in school girls should focus on correcting iron deficiency. Surveillance systems for anemia may consider using a cut-off point that is specific for the method of blood sampling and the method of Hb measurement.
Risk Factors For Workplace Encounters With Weapons By Hospital Employees, James Blando, Chalsie Paul, Mariana Szklo-Coxe
Risk Factors For Workplace Encounters With Weapons By Hospital Employees, James Blando, Chalsie Paul, Mariana Szklo-Coxe
Community & Environmental Health Faculty Publications
Objective:The specific aim of this study was to determine which risk factors were associated with frequent weapons confiscation in a healthcare facility. This study investigated the hypothesis that hospital-related factors impact the frequency of weapons confiscation.
Study design:Cross-sectional.
Methods:A cross-sectional survey was administered on-line to hospital security directors and assessed the associations of organizational factors with the frequency of weapons confiscation.
Results:It was found that hospitals with metal detectors were more than 5 times as likely to frequently confiscate weapons, suggesting this intervention is effective. It was also found that hospitals with psychiatric units were more likely to have frequent …
An Analysis Of Inclusion Resources, As A Pathway To Retention Of Minority Students In The Medical Profession, Beverly K. Andre
An Analysis Of Inclusion Resources, As A Pathway To Retention Of Minority Students In The Medical Profession, Beverly K. Andre
PCOM Capstone Projects
What is Diversity? Retention? Often, these terms are used interchangeably without true understanding of their individual meanings. Diversity is offering a variety or having multiple ethnicities amongst a cohort in proportions seen within society. However, retention refers to the continuous possession or maintenance of the variation seen in said cohort. With regards to medical institutions, it seems that there is no separation. Many medical institutions seek to be diverse and create a picture of multiethnic cohorts but regrettably, effective retention techniques aren’t always adopted to make these visions a reality. The damage caused by the lack of adequate retention techniques …
A Systematic Review Of The Of Factors Contributing To Sustained Homelessness And Those Influencing The Deterioration Of Homeless Health And Healthcare, Mojisola Delano
A Systematic Review Of The Of Factors Contributing To Sustained Homelessness And Those Influencing The Deterioration Of Homeless Health And Healthcare, Mojisola Delano
PCOM Capstone Projects
Homelessness is a perpetual problem occurring in society. With a lack of competency of either government institutions or private establishments to provide the required intervention to provide shelter and aid for the existing homeless population or to prevent further homelessness; the next best objective would be to keep this population healthy, by employing hygiene interventions. However, there is a serve lack in hygiene interventions as well. A few US cities and many counties abroad have begun to research and implement strategies for sanitary intervention in homeless hygiene in hopes that if they are unable to “cure” homelessness, then they can …
A Discrete Age Structured Model Of Hantavirus In A Rodent Reservoir In Paraguay, Megan A. Rúa
A Discrete Age Structured Model Of Hantavirus In A Rodent Reservoir In Paraguay, Megan A. Rúa
Biological Sciences Faculty Publications
Many rodent-borne hantaviruses are zoonotic pathogens that can cause disease in humans through inhalation of aerosolized rodent excreta. To evaluate the prevalence of Jaborâ virus (JABV) over time within its rodent reservoir, Akodon montensis, we formulated a mathematical model with multiple rodent age classes and unique infection class progression features. We then parameterized the model with data collected from a survey of JABV harbored by Akodon montensis in the Mbaracayú Reserve in Paraguay. Our model incorporates three types of infection over the lifetime of the rodent as well as a recovered class. A new feature of the model allows transition …
Defining Current Gaps In Quality Measures For Cancer Immunotherapy: Consensus Report From The Society For Immunotherapy Of Cancer (Sitc) 2019 Quality Summit, Sara Pai, David Blaisdell, Rachel Brodie, Robert G. Carlson, Heidi Finnes, Michele Galioto, Roxanne E. Jensen, Tom Valuck, Antonia R. Sepulveda, Howard L. Kaufman
Defining Current Gaps In Quality Measures For Cancer Immunotherapy: Consensus Report From The Society For Immunotherapy Of Cancer (Sitc) 2019 Quality Summit, Sara Pai, David Blaisdell, Rachel Brodie, Robert G. Carlson, Heidi Finnes, Michele Galioto, Roxanne E. Jensen, Tom Valuck, Antonia R. Sepulveda, Howard L. Kaufman
Population and Public Health Sciences Faculty Publications
Background Quality measures are important because they can help improve and standardize the delivery of cancer care among healthcare providers and across tumor types. In an environment characterized by a rapidly shifting immunotherapeutic landscape and lack of associated long-term outcome data, defining quality measures for cancer immunotherapy is a high priority yet fraught with many challenges. Methods Thus, the Society for Immunotherapy of Cancer convened a multistakeholder expert panel to, first, identify the current gaps in measures of quality cancer care delivery as it relates to immunotherapy and to, second, advance priority concepts surrounding quality measures that could be developed …
The Va Mission Act Of 2018: A Potential Game Changer For Rural Gme Expansion And Veteran Health Care, Anne Victoria Neale, Phil Lupo, Marjorie A. Bowman, Dean A. Seehusen
The Va Mission Act Of 2018: A Potential Game Changer For Rural Gme Expansion And Veteran Health Care, Anne Victoria Neale, Phil Lupo, Marjorie A. Bowman, Dean A. Seehusen
Population and Public Health Sciences Faculty Publications
The Veterans Healthcare Administration (VHA) is the largest health care delivery system in the United States. It includes 172 medical centers (VAMCs), with over 1,100 Community Based Outpatient Centers (CBOCs) and various other sites of care. In addition to training physicians to care for veterans and active duty service members, the VHA is also directed to assist in supplying health care personnel to the nation.Through its Office of Academic Affiliations (OAA), VHA develops partnerships with Accreditation Council for Graduate Medical Education (ACGME)/American Osteopathic Association (AOA) accredited residency program sponsoring institutions. These collaborations include 144 out of 152 allopathic medical schools …
Individual Ems Disposition In The Prehospital Setting To Predict Future Opioid Overdose And Mortality, Lillie Valliere
Individual Ems Disposition In The Prehospital Setting To Predict Future Opioid Overdose And Mortality, Lillie Valliere
Global Public Health | Senior Theses
Introduction
There have been over 400,000 deaths related to prescription opioids in the US since 1999, with the highest prevalence among individuals aged 45-54 years old. However, adults between the ages of 18 and 34 have the highest prevalence of misuse of prescription opioids. With accidental overdoses as a leading cause of death, Marin County is just one community that is heavily impacted by this ongoing epidemic. Statistics related to non-fatal and fatal opioid overdoses are difficult to accurately count due to the differing ways counties may categorize cause of death, diagnoses, and other contributing factors. However, looking at 911 …
Effects Of Latinx Parental English Proficiency On Stress, Maria Alvarez Pineda
Effects Of Latinx Parental English Proficiency On Stress, Maria Alvarez Pineda
Global Public Health | Senior Theses
Background
In the United States, patients who have Limited English Proficiency (LEP) report having more problems communicating with their children’s doctor which leads to these children having worse health care access than those who have parents with a High English Proficiency (HEP). Parents with LEP also experience discrimination in this setting which can lead to increased psychological distress. The goal of this study was to determine if the level of English Proficiency is associated to stress levels and discrimination among Latinx parents when they take their chidlren to the doctor.
Methods
Participants consisted of 22 Latinx parents (86.4% Mexican and …
Communication Of Professional Readiness In Dietetics And Human Nutrition Undergraduates: A Pilot Study, Heather Norman-Burgdolf, Emily M. Dewitt, Nathan L. Vanderford, Julie Plasencia
Communication Of Professional Readiness In Dietetics And Human Nutrition Undergraduates: A Pilot Study, Heather Norman-Burgdolf, Emily M. Dewitt, Nathan L. Vanderford, Julie Plasencia
Dietetics and Human Nutrition Faculty Publications
Learning experiences within the dietetics and human nutrition undergraduate curricula develop knowledge and skills pertinent to student career goals. Core competency requirements are extensively assessed in these programs, yet the communication of transferable skills gained and student professional readiness are rarely examined. The purpose of this study was to evaluate undergraduate students' perceived professional readiness following six professional development workshops on transferable skills and career preparedness communicated through resumes and personal statements. In this pilot study, twelve upper-level dietetics and human nutrition students self-assessed their resumes and personal statements with rubrics and completed surveys before and after the intervention. Following …