Medicine and Health Sciences Commons^™

Release: A Protocol For A Systematic Review Based, Individual Participant Data, Meta- And Network Meta-Analysis, Of Complex Speech-Language Therapy Interventions For Stroke-Related Aphasia, Marian C. Brady, Myzoon Ali, Kathryn Vandenberg, Linda J. Williams, Louise R. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A. Copeland, Tamara B. Cranfill, Marie Di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jackie Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis M. T. Jesus, Maria Kambanaros, Eun Kyoung Kang, Eman M. Khedr, Anthony Pak Hin Kong, Tarja Kukkonen, Marina Laganaro, Matthew A. Lambon Ralph, Ann Charlotte Laska, Beatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian Macwhinney, Rebecca Shisler Marshall, Flavia Mattioli, Ilknur Mavis, Marcus Meinzer, Reza Nilipour, Enrique Noe, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida F. Patricio, Isabel Pavão Martins, Cathy Price, Tatjana Prizl Jakovac, Elizabeth Rochon, Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B. Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P. Szaflarski, Shirley A. Thomas, Mieke Van De Sandt-Koenderman, Ineke Van Der Meulen, Evy Visch-Brink, Linda Worrall, Heather Harris Wright

HPD Articles

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.

Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.

Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison …

Health Access Network: Mehaf Addiction Care Program, Mary Lindsey Smith Phd, Katie Rosingana Ba, Rachel M. Gallo Mph, Evelyn Ali Bs

Substance Use Research & Evaluation

No abstract provided.

Continuation Of Midodrine Upon Icu Discharge, Fahad Hussain, Deepti S. Rao

Quality Improvement/Patient Safety Symposium

Indications for Continuation of Alpha-1 Agonist Midodrine Upon ICU Discharge

Hussain, Fahad, MSII; Rao, Deepti, MD

Introduction:

Persistent hypotension in patients affected by circulatory shock is a common barrier to discharge in the ICU. Even after these patients have been otherwise stabilized, low-level hypotension often ensures that they remain in the ICU on IV vasopressors. Midodrine, an oral α1-agonist, has shown promise as an adjunct therapy to wean patients off IV vasopressors and facilitate earlier discharge from the ICU. According to a recent study done at the Mayo Clinic ICU, Rochester, discharge on Midodrine was associated with a shorter ICU …

The Effect Of Time-Restricted Feeding On Body Weight, Energy, Mood, Sleep, And Hunger Levels Of Adults On Social Media, Rachel Elizabeth Haines

Master's Theses

The purpose of this study was to investigate the effect of time-restricted eighthour feeding on body weight, self-reported energy, mood, and hunger scores, and selfreported sleep patterns of adult men and women on social media. Generally healthy adults ages 18 to 65 were invited on social media to participate in a five-week study which involved a one week of following their normal dietary patterns succeeded by four weeks of practicing time-restricted feeding of eight hours per day, also known as 16 hours of fasting. Daily surveys were created in Survey Monkey and distributed through the messaging platform, Remind, that gathered …

Evaluation Of Antibody Response Directed Against Porcine Reproductive And Respiratory Syndrome Virus Structural Proteins, Hung Q. Luong, Huong T.L. Lai, Hiep L.X. Vu

Nebraska Center for Virology: Faculty Publications

Luciferase-immunoprecipitation system (LIPS), a liquid phase immunoassay, was used to evaluate antibody responses directed against the structural proteins of PRRSV in pigs that were experimentally infected with virulent PRRSV strains. First, the viral N protein was used as a model antigen to validate the assay. The LIPS results were highly comparable to that of the commercial IDEXX PRRS X3 ELISA. Subsequently, the assay was applied to simultaneously measure antibody reactivity against all eight structural proteins of PRRSV. The highest immunoreactivities were detected against GP3, M, and N proteins while the lowest reactivity was detected against ORF5a protein. Comparative analysis of …

Office Of Equity Diversity Report Annual Report Fy2020, Children's Mercy Hospital

Equity & Diversity Annual Reports

A report on equity and diversity at Children's Mercy Hospitals & Clinics, in the care it provides, the people it serves, and in its workforce. Specifically discusses the Equity & Diversity Leadership Structure, Employee Demographics, Patient Demographics, lasting impressions from FY20, and the future of healthcare providers.

The Provider Perspective On Behavioral Health Care For Transgender And Gender Nonconforming Individuals In The Central Great Plains: A Qualitative Study Of Approaches And Needs, Natalie Holt, Debra A. Hope, Richard Mocarski, Heather Meyer, Robyn King, Nathan Woodruff

Trans Collaborations Academic Papers

Purpose—Transgender and gender nonconforming (TGNC) individuals interact with mental health care systems at high rates and experience substantial barriers to care. Rural TGNC individuals face additional disparities in accessing appropriate mental health services. Little research has focused on the mental healthcare providers who work with TGNC individuals in underserved areas. The current study sought to describe the mental health care services delivered by providers perceived as affirming by TGNC community members in the Central Great Plains.

Methods—We conducted qualitative interviews with 10 providers to understand how providers seek cultural competency and conceptualize and work with their TGNC clients given the …

Gulls As Sources Of Environmental Contamination By Colistin-Resistant Bacteria, Alan B. Franklin, Andrew M. Ramey, Kevin T. Bentler, Nicole L. Barrett, Loredana M. Mccurdy, Christina A. Ahlstrom, Jonas Bonnedahl, Susan A. Shriner, Jeffrey C. Chandler

United States Department of Agriculture Wildlife Services: Staff Publications

In 2015, the mcr-1 gene was discovered in Escherichia coli in domestic swine in China that conferred resistance to colistin, an antibiotic of last resort used in treating multi-drug resistant bacterial infections in humans. Since then, mcr-1 was found in other human and animal populations, including wild gulls. Because gulls could disseminate the mcr-1 gene, we conducted an experiment to assess whether gulls are readily colonized with mcr-1 positive E. coli, their shedding patterns, transmission among conspecifics, and environmental deposition. Shedding of mcr-1 E. coli by small gull flocks followed a lognormal curve and gulls shed one strain >101 …

Piscivorous Bird Use Of Aquaculture And Natural Water Bodies In Mississippi, Paul C. Burr, Jimmy I. Avery, Garrett M. Street, Bronson K. Strickland, Brian S. Dorr

United States Department of Agriculture Wildlife Services: Staff Publications

Double crested cormorants (Phalacrocorax auritus) and great egrets (Ardea alba) have an extensive history of human wildlife conflict with the aquaculture industry of western Mississippi, USA, due to

their depredation of cultured catfish (Ictalurus spp.). Although aquaculture is abundant, western Mississippi also contains naturally occurring water bodies that offer alternative forage opportunities to these species. How cormorants or egrets distribute themselves among these 2 foraging options is unknown, but it has been generally assumed each species uses aquaculture disproportionately more because of the high density of available prey. To test this assumption, we surveyed these …

Control Or Eradication: Problems In The Management Of Invasive Birds, Michael L. Avery, Chris J. Feare

United States Department of Agriculture Wildlife Services: Staff Publications

Humans have captured, transported and intentionally released wild birds for centuries (Blackburn et al., 2009). Motivations for such purposeful introductions include food (West and Zhou, 2007), religion (Agoramoorthy and Hsu, 2007), sport (McDowall, 1994), biocontrol (Bennett and Hughes, 1959; Kurdila, 1995) and aesthetics (Ryan, 1906; Thomson, 1922). Many purposeful bird introductions were the work of acclimatization societies, particularly in North America, New Zealand and Australia. These societies were formed in the 19th century by European settlers to transport bird species from their homelands in efforts to establish them in the newly settled regions (Thomson, 1922; Dunlap, 1997). As a result …

Impact Of The Affordable Care Act On Referral To Care For People Living With Hiv In Appalachia, Cameron A. Wade, Timothy N. Crawford, Nicole Leedy, Alice C. Thornton

Family Medicine Faculty Publications

Introduction: The Affordable Care Act (ACA) enacted on March 23, 2010 significantly impacted access to healthcare for people living with HIV (PLWH). Expansion of care was accomplished in three areas: eliminating exclusions for pre-existing conditions, elimination of lifetime caps on healthcare expenditures, and expansion of Medicaid eligibility.

Purpose: This study evaluated the impact of state implementation of the ACA Medicaid expansion on referral to HIV care at a Ryan White federally funded clinic in Kentucky (University of Kentucky Bluegrass Care Clinic [UK BCC]).

Methods: Retrospective chart review of all newly enrolled patients at the UK BCC between March 2010 and …

Task-Offload Tools Improve Productivity And Performance In Geopolitical Forecasting, Ion Juvina, Othalia Larue, Colin Widmer, Subhashini Ganapathy, Srikanth Nadella, Brandon Minnery, Lance Ramshaw, Emile Servan-Schreiber, Maurice Balick, Ralph Weischedel

Psychology Faculty Publications

Recent studies in geopolitical forecasting have identifiedpsychological variables that predict forecasting accuracy.We studied the effect of providing human forecasters withautomated information search and task management supporttools. Our research aimed to determine whether use of thesupport tools could explain additional variance in forecast-ing performance above and beyond psychological variables.We found that the provided tools encouraged participants todo more work (i.e., information search, communication, re-flection, etc.), which in turn resulted in improved forecast-ing performance.

Someone's Missing...And I Think It's Me: Our Great Adventure With Dementia, J. L. Gaustad

Someone's Missing...and I Think It's Me

Someone’s Missing…and I Think It’s Me is a unique blend of memoir, advice, and art. Gaustad chronicles her experiences with her late husband, prominent artist and VCU faculty member Gerald Donato, as they try to navigate the mysteries and terrors of early-onset dementia. Beautifully illustrated with original artwork by the author, Donato, and artist friends, Gaustad takes a brutally honest, sometimes harrowing, and ultimately life-affirming look at their challenged marriage. Although her original intent was to create a guide for those dealing with brain illness in loved ones, the book became a testament to the beauty and humor to be …

Covid-19 In Indigenous Communities: Five Protective Factors Of “Exercising” Sovereignty, Kelsey Leonard, Natalie Welch, Alisse Ali-Joseph

Faculty Publications

Indigenous Peoples have an inherent responsibility and right to “exercising” sovereignty - the practice of sport and physical activity in performance of our cultural, political, and spiritual citizenship (Ali-Joseph 2018). During the COVID-19 pandemic, access to and equity (inequity) in sport and physical activity has been felt (physically, spiritually, politically) within Indigenous communities. We implement an abundance-based Indigenous approach to understanding Indigenous Peoples’ responses to the coronavirus pandemic through sport and its far-reaching ramifications in Indian Country. In response to the COVID-19 pandemic we have seen Indigenous Peoples utilize social media such as Facebook and TikTok to reimagine Indigenous sport …

The Protection Of Children And Their Rights: A Comparison Between The United States And Costa Rica, Abigail Rothweiler

Undergraduate Research Symposium

Abstract:

Introduction: In Missouri, there are over 13,000 children who are currently receiving care through the state foster care system. Because being removed from their families causes life-long trauma and decreased quality of life for many children, it is important that the situation is approached in the best way. While there are differences between St. Louis, Missouri and San Jose, Costa Rica, the Costa Rican child welfare system, El Patronato Nacional de Infancia (PANI), uses several strategies that may be beneficial in St. Louis.

Purpose: To examine the current policies and programs in San Jose, Costa Rica to …

Silver Salt-Mediate Benzylation Of Carbohydrates Under Mildly Acidic Conditions, Nicholas Forsythe, Samira Escopy, Yashapal Singh 2436808, Alexei Demchenko

Undergraduate Research Symposium

When looking at biomolecules, carbohydrate represent a large group of macromolecules that play an important role in the body. Most importantly, carbohydrates provide an energy supply for organisms, but it is proven that they are also involved in a myriad of other processes. Furthermore, synthesizing these molecules leads to advancements in chemistry, such as drug design, and other structures such as glycolipids play important roles in the immune system. Understanding this, an efficient and reliable way to create these carbohydrates is needed.

The protection and deprotection manipulations of carbohydrates play an essential role in synthetic carbohydrate chemistry.¹ Using benzyl …

Improving Preclinical To Clinical Translation In Alzheimer's Disease Research., Stacey J Sukoff Rizzo, Andi Masters, Kristen D. Onos, Sara Quinney, Michael Sasner, Adrian Oblak, Bruce T Lamb, Paul R Territo, Model-Ad Consortium

Faculty Research 2020

Introduction: Preclinical testing in animal models is a critical component of the drug discovery and development process. While hundreds of interventions have demonstrated preclinical efficacy for ameliorating cognitive impairments in animal models, none have confirmed efficacy in Alzheimer's disease (AD) clinical trials. Critically this lack of translation to the clinic points in part to issues with the animal models, the preclinical assays used, and lack of scientific rigor and reproducibility during execution. In an effort to improve this translation, the Preclinical Testing Core (PTC) of the Model Organism Development and Evaluation for Late-onset AD (MODEL-AD) consortium has established a rigorous …

Is There A Relationship Between Having Residency Application Personal Statements Reviewed By The Library's Editing Service And Medical Students' Match Into Their Preferred Residency Specialty?, Lisa Price, Jamie L. Pelley

Libraries Scholarship

Objectives: This study investigates whether there is a relationship between Rowan University School of Osteopathic Medicine's fourth-year medical students' acceptance into their preferred specialty for residency and their submission of the Personal Statement portion of their residency application for review/edit by the Library's editing service. We hope that our results will aid other institutions which may be considering whether to provide a similar service.

Methods: This case-control study reviews Match records for the years 2018 and 2019 (the years for which data was available) and compares the Match rates into the preferred residency specialty of those who submitted their Personal …

Life In Hampton Roads Survey Press Release #3: Hurricanes And Covid-19, Social Science Research Center, Old Dominion University

Life in Hampton Roads Survey Report

Hurricane Evacuation & Sheltering During COVID-19

The 2020 Life in Hampton Roads (LIHR) survey includes several questions concerning how residents plan to prepare for and respond to hurricanes during the COVID19 pandemic.

Life In Hampton Roads Survey Press Release #8: Health And Covid-19, Social Science Research Center, Old Dominion University

Life in Hampton Roads Survey Report

Life in Hampton Roads: COVID-19 and Health

The 2020 survey included several questions about health-related concerns and behaviors of residents during the COVID-19 pandemic. Responses provide insight into the experiences and concerns of Hampton Roads citizens around a variety of health-related topics.

Despite the COVID-19 pandemic, about three-quarters of Hampton Roads residents felt that their health in general was good (19.6%) or excellent (55.8%). Only 2.7% rated their health as poor while one in five rated their health as fair (20.8%).

Life In Hampton Roads Survey Press Release #2: Policy And Local Response Covid-19, Social Science Research Center, Old Dominion University

Life in Hampton Roads Survey Report

Life in Hampton Roads: Politics, Policy and COVID-19 Response

The survey included several questions that provide a window into the views of Hampton Roads citizens concerning policy choices and leadership during the COVID-19 pandemic response. Overall and on most issues the public was quite divided, with divisions often falling along party lines, but President Trump and the Centers for Disease Control and Prevention (CDC) seemed to elicit the strongest negative and positive responses, respectively. A substantial majority approved of Governor Northam’s timing on the initial stay-at-home order, and respondents leaned toward the view that additional restrictions on public activity should …

Implementation Of The Lasater Clinical Judgment Rubric As A Progress Review Tool, Lydia Lazzara

Nursing DNP Projects

The organization determined there was a lack of a standardized progress review tool to objectively evaluate nurses’ clinical judgment during orientation. Further assessment determined gaps in communication between the preceptors and unit-based nursing education specialists (NESs), and a perceived lack of value in progress reviews. Tanner’s (2006) review of nearly 200 nursing research articles determined a nurse’s clinical judgments impact patient outcomes, making it imperative that organizations ensure their nurses have adequate clinical judgment to protect patients. Lasater’s clinical judgment rubric (LCJR), based on Tanner’s (2006) clinical judgment model was the only published tool found for assessing nurses’ clinical judgment. …

Alteration Of The Gut Microbiome In Normal And Overweight School Children From Selangor With Lactobacillus Fermented Milk Administration, Narcisse Joseph, Jonathan B. Clayton, Susan L. Hoops, Carter A. Linhardt, Amalia Mohd Hashim, Barakatun Nisak Mohd Yusof, Suresh Kumar, Syafinaz Amin Nordin

Food for Health: Publications

Childhood obesity is a serious public health problem worldwide. Perturbations in the gut microbiota composition have been associated with the development of obesity in both children and adults. Probiotics, on the other hand, are proven to restore the composition of the gut microbiome which helps reduce the development of obesity. However, data on the effect of probiotics on gut microbiota and its association with childhood obesity is limited. This study aims to determine the effect of probiotics supplement intervention on gut microbiota profiles in obese and normal-weight children. A total of 37 children, 17 normal weight, and 20 overweight school …

Stool Microbiome, Ph And Short/Branched Chain Fatty Acids In Infants Receiving Extensively Hydrolyzed Formula, Amino Acid Formula, Or Human Milk Through Two Months Of Age, Car Reen Kok, Bradford Brabec, Maciej Chichlowski, Cheryl L. Harris, Nancy Moore, Jennifer L. Wampler, Jon Vanderhoof, Devin Rose, Robert Hutkins

Food for Health: Publications

CRISPR–Cas is an anti-viral mechanism of prokaryotes that has been widely adopted for genome editing. To make CRISPR–Cas genome editing more controllable and safer to use, anti-CRISPR proteins have been recently exploited to prevent excessive/prolonged Cas nuclease cleavage. Anti-CRISPR (Acr) proteins are encoded by (pro)phages/(pro)viruses, and have the ability to inhibit their host’s CRISPR–Cas systems. We have built an online database AcrDB (http://bcb.unl.edu/AcrDB) by scanning ∼19 000 genomes of prokaryotes and viruses with AcrFinder, a recently developed AcrAca (Acr-associated regulator) operon prediction program. Proteins in Acr-Aca operons were further processed by two machine learning-based programs (AcRanker and PaCRISPR) to obtain …

Effects Of Ankle Angular Position And Standing Surface On Postural Control Of Upright Stance, Fawaz A. Alwadani, Huaqing Liang, Alexander S. Aruin

Physical Therapy Faculty Research

The purpose of the study was to investigate the effects of ankle angular position and standing surface type on static upright balance. Ten young adults stood on a force platform or on a firm wedge that induced 15° of either dorsiflexion or plantarflexion. In addition, a piece of foam was placed on top of the force platform and on the wedge. The center of pressure distance and velocity in the anteroposterior and mediolateral directions were calculated. Significantly larger magnitudes in most of the investigated variables were seen while standing with ankles in the dorsiflexion when compared with standing with the …

Machine Learning Prediction Of Glioblastoma Patient One-Year Survival, Andrew Du '20, Warren Mcgee, Jane Y. Wu

Student Publications & Research

Glioblastoma (GBM) is a grade IV astrocytoma formed primarily from cancerous astrocytes and sustained by intense angiogenesis. GBM often causes non-specific symptoms, creating difficulty for diagnosis. This study aimed to utilize machine learning techniques to provide an accurate one-year survival prognosis for GBM patients using clinical and genomic data from the Chinese Glioma Genome Atlas. Logistic regression (LR), support vector machines (SVM), random forest (RF), and ensemble models were used to identify and select predictors for GBM survival and to classify patients into those with an overall survival (OS) of less than one year and one year or greater. With …

Formative Work To Design A Digital Learning Self-Assessment And Feedback Tool To Prevent Weight Gain Among College Students, M.A Napolitano, S.B. Lynch, M.N. Mavredes, B.D. Shambon, L. Posey

Health Sciences Education Research

Objective: While colleges have implemented brief, tailored interventions for health-risk areas such as alcohol prevention, theoretically-guided digital learning offerings for weight gain prevention have lagged behind in programming and implementation. Thus, the objective was to design and usability test a weight gain prevention digital learning platform for college students with modules targeting key nutrition and physical activity behaviors. Methods: Development occurred in iterative phases: formative research, descriptive normative data collection, prototype development, and usability testing. Formative research consisted of background work and survey administration to incoming and current freshmen. Prototype development was guided by theories of behavior change and cognitive …

Himmelfarb Library Annual Report 2020, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Annual Report

No abstract provided.

Improvement In Overground Walking After Treadmill-Based Gait Training In A Child With Agenesis Of The Corpus Callosum, Gena Henderson, Matthew Beerse, Huaqing Liang, Diego Ferreira, Jianhua Wu

Physical Therapy Faculty Research

Background: Agenesis of the corpus callosum (ACC) is a rare congenital brain defect that produces a wide variety of cognitive and motor impairments. Literature regarding the response of pediatric populations with ACC to physical rehabilitation is scarce. Treadmill-based gait training (TT) has been shown to improve walking ability in some pediatric populations but has not been investigated in children with ACC.

Objective: The purpose of this study was to investigate the effect of a novel treadmill intervention paradigm on the gait parameters of a child with ACC.

Design: A single-participant design with 2 phases was used.

Methods: The settings were …

Imaginary Companions: The Children Who Create Them And The Adult Response, Sarah Tsang

Undergraduate Honors College Theses 2016-

As a part of childhood development, the need for companionship and socialization are a necessity. But what happens when a child does not have any friends or adults to socialize with? Imaginary friends (also known as imaginary companions or ICs) are created to befriend children and help them develop their emotions. This thesis is a literary study about the field of imaginary companions, the children who create them, and the response the environment has to these “invisible friends.”