Medicine and Health Sciences Commons^™

Effects Of Intermittent Pneumatic Compression On Delayed Onset Muscle Soreness (Doms) In Long Distance Runners, Shane N. Draper, Emily L. Kullman, Kenneth E. Sparks, Kathleen Little, Joan Thoman

Nursing Faculty Publications

© 2020, Western Kentucky University. All rights reserved. The purpose of this study was to observe the effectiveness of intermittent pneumatic compression (IPC) on reducing C-reactive protein (CRP) and DOMS after long distance running. Ten distance runners, five males and five females, ages 20-53 years performed two 20mile runs at 70% VO2 max. Each run was followed by either no treatment (control) or IPC treatment for five consecutive days. For the IPC run, participants were treated for one hour immediately following the run and daily for five more days thereafter. On control runs, participants did not receive any treatment. Serum …

Hepatitis B Seroprevalence In The U.S. Military And Its Impact On Potential Screening Strategies, Paul T. Scott, Robert L. Cohen, David Brett-Major, Shilpa Hakre, Jennifer A. Malia, Jason F. Okulicz, Charmagne G. Beckett, Jason M. Blaylock, Michael A. Forgione, Stephen A. Harrison, Clinton K. Murray, Francisco J. Rentas, Roland L. Fahie, Adam W. Armstrong, Aatif M. Hayat, Laura A. Pacha, Peter Dawson, Beth Blackwell, Angelia A. Eick-Cost, Hala H. Maktabi, Nelson L. Michael, Linda L. Jagodzinski, Steven B. Cersovsky, Sheila A. Peel

Journal Articles: Epidemiology

INTRODUCTION: Knowledge of the contemporary epidemiology of hepatitis B virus (HBV) infection among military personnel can inform potential Department of Defense (DoD) screening policy and infection and disease control strategies.

MATERIALS AND METHODS: HBV infection status at accession and following deployment was determined by evaluating reposed serum from 10,000 service members recently deployed to combat operations in Iraq and Afghanistan in the period from 2007 to 2010. A cost model was developed from the perspective of the Department of Defense for a program to integrate HBV infection screening of applicants for military service into the existing screening program of screening …

Evaluation Of The Therapeutic Efficacy Of Praziquantel Against Schistosomes In Seven Countries With Ongoing Large-Scale Deworming Programs, B. Levecke, J. Vlaminck, L. Andriamaro, S. Ame, V. Belizario, Abraham Degarege, D. Engels, B. Erko, A. D. Garba, G. M. Kaatano, Z. Mekonnen, A. Montresor, P. Olliaro, O. S. Pieri, M. Sacko, S. O. Sam-Wobo, L. A. Tchuem Tchuenté, J. P. Webster, J. Vercruysse

Journal Articles: Epidemiology

The World Health Organization (WHO) recommends periodic assessment of the therapeutic efficacy of praziquantel (PZQ) to detect reduced efficacy that may arise from drug resistance in schistosomes. In this multi-country study (2014), we assessed the therapeutic efficacy of a single oral dose of PZQ (40 mg/kg) against Schistosoma mansoni (Brazil, Cameroon, Ethiopia, Mali, Madagascar and Tanzania), S. haematobium (Cameroon, Ethiopia, Mali, Tanzania and Zanzibar) and S. japonicum (the Philippines) infections in school-aged children, across a total of 12 different trials. Each trial was performed according to the standardized methodology for evaluating PZQ efficacy as described by the WHO. Overall, therapeutic …

Nanoformulation Of The Superoxide Dismutase Mimic, Mntnbuoe-2-Pyp5+, Prevents Its Acute Hypotensive Response, Sarah L. Schlichte, Svetlana Romanova, Kenichi Katsurada, Elizabeth A. Kosmacek, Tatiana K. Bronich, Kaushik K. Patel, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman

Journal Articles: Cellular & Integrative Physiology

Scavenging superoxide (O₂^•-) via overexpression of superoxide dismutase (SOD) or administration of SOD mimics improves outcomes in multiple experimental models of human disease including cardiovascular disease, neurodegeneration, and cancer. While few SOD mimics have transitioned to clinical trials, MnTnBuOE-2-PyP⁵⁺ (BuOE), a manganese porphyrin SOD mimic, is currently in clinical trials as a radioprotector for cancer patients; thus, providing hope for the use of SOD mimics in the clinical setting. However, BuOE transiently alters cardiovascular function including a significant and precipitous decrease in blood pressure. To limit BuOE's acute hypotensive action, we developed a mesoporous silica nanoparticle …

Addiction After Taking Pain Relief Medicine For Post-Surgery, Kelie A. Nicholson Vélez

College of Pharmacy Student Research

No abstract provided.

The Pharmacokinetics Of A Novel Anti-Renalase Antibody Used For The Treatment Of Melanoma In A Congenic Mouse Species, Oriyomi Alimi

Yale Medicine Thesis Digital Library

The pharmacokinetics of a humanized anti-RNLS monoclonal antibody used for the treatment of melanoma in a congenic mouse species

Authors: Oriyomi Alimi1, Gary Desir1

1Department of Internal Medicine, Yale School of Medicine, New Haven, CT

Cancer cells can overcome signaling that restrains their growth and promotes senescence and cell death. Renalase (RNLS) is a secreted flavoprotein that functions as a survival factor after ischemic and toxic injury, signaling through the plasma calcium channel PMCA4b to activate the PI3K/AKT and MAPK pathways. In addition, recent studies, indicate that dysregulated RNLS signaling promotes survival of melanoma cells due to its capacity to …

Neonatal Outcomes In Planned Community Birth Settings, Catherine E. Binger, Kaitlin Kinkoph

All Electronic Theses and Dissertations

Background/Purpose: The safety of community births is a common point of discussion, especially in regard to neonates. Planned community births are supported for low risk, informed patients by the ACNM. The purpose of this literature review was to understand neonatal morbidity and mortality in planned community birth settings. Theoretical Framework: Orlando’s Nursing Theory focuses on immediate patient needs and promotes growth of nurses in unstable environments. This theory applies the competency of the nurse’s practice and the satisfaction of the patient. The Orlando Nursing Theory will be applied and explored as a framework in relation to neonatal outcomes in different …

Effect Of Silver Diamine Fluoride On Candida Albicans Associated With Early Childhood Caries, Sarah Al Kukash

Student Theses, Dissertations and Capstones

BACKGROUND: Early childhood caries (ECC) is one of the most prevalent infectious diseases in childhood worldwide. It afflicts 23% of the preschoolers in the U.S. It most frequently targets children from poor socioeconomic families and racial/ethnic minority backgrounds and becomes a serious public health problem. The major pathogen of ECC is Streptococcus mutans (S. mutans). However, the occurrence of ECC is positively associated with the presence of Candida albicans (C. albicans). It is well established that Silver Diamine Fluoride (SDF), a recent Food and Drug Administration (FDA)-off labeled approved agent for arresting dental caries, exhibits a robust antibacterial effect on …

Teaming For Transition: Interprofessional Collaboration, Megan Sturdivant, Emily Thompson, Sam Skelton, Rebecca Mallory

2020 Honors Symposium

The transition from youth to young adult for individuals with severe disabilities is difficult, provides few opportunities for employment, and offers less of a chance to connect with friends and engage with people. This research presents ways that speech-language pathologists, occupational therapists, school counselors, and special educators can collaborate to create a successful transition process for individuals with severe disabilities.

Development Of Early Social Interactions In Infants Exposed To Artificial Intelligence From Birth, Anna Vest

2020 Honors Symposium

Emersion in a ‘smart’ world of technology starts the day an infant enters the door of a home shared with Amazon Alexa, Siri, Nest, and perhaps a smart baby bassinet. This exposure raises a question about how artificial intelligence might yield a different experience in social and interactive life for infants that have been exposed to it from their earliest days.

Ethical Imperatives Critical To Effective Disease Control In The Coronavirus Pandemic: Recognition Of Global Health Interdependence As A Driver Of Health And Social Equity, George A. Gellert Md, Mph, Mpa

Journal of Health Ethics

Ethical imperatives critical to effective disease control in the coronavirus pandemic: Recognition of global health interdependence as a driver of health and social equity

George A. Gellert MD, MPH, MPA

ABSTRACT

Decades into the era of emerging infectious diseases, the 2019-2020 coronavirus pandemic has caught the world, and the United States in particular, poorly prepared to engage effective public health disease prevention and control measures. In part, this reflects poor public health planning, response, logistical preparation and pandemic readiness, and complacency by governments and disease control agencies. In terms of future responses to emerging infection pandemics, these deficiencies can be …

Assessing Food Insecurity During Covid-19 Pandemic, Kevin Fitzpatrick

COVID-19

Presentation: Assessing Food Insecurity During COVID-19 Pandemic

Assessing Food Insecurity In The United States During Covid-19 Pandemic, Kevin M. Fitzpatrick, Casey Harris, Grant Drawve

COVID-19

Means and number/percentage of respondents for each state are presented in Table 1. These responses are based on a representative, post-strata weighted national sample (n=10,368) of US adults collected in the last week of March 2020. Even though the responses are weighted, in those states where fewer than 50 respondents are surveyed, those states are treated as missing cases and food insecurity percentages are not provided.

Osteopathic Medicine Program 2020, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Mobile Technology Intervention For Weight Loss In Rural Men: Protocol For A Pilot Pragmatic Randomised Controlled Trial, Christine M. Eisenhauer, Fabiana Almeida Brito, Aaron M. Yoder, Kevin A. Kupzyk, Carol H. Pullen, Katherine E. Salinas, Jessica Miller, Patricia A. Hageman

Journal Articles: Physical Therapy

INTRODUCTION: Men who are overweight or obese in the rural Midwestern USA are an unrepresented, at-risk group exhibiting rising rates of cardiovascular disease, poor access to preventive care and poor lifestyle behaviours that contribute to sedentary lifestyle and unhealthy diet. Self-monitoring of eating and activity has demonstrated efficacy for weight loss. Use of mobile technologies for self-monitoring eating and activity may address rural men's access disparities to preventive health resources and support weight loss. Our pilot trial will assess the feasibility and acceptability of two mobile applications for weight loss in rural men to inform a future, full-scale trial.

METHODS …

The Potential Effects Of Hormonal Therapy And Stress On The Oral Health Of The Transitioning Population, Elena G. Cantwell, Devon Mcclure

Dental Hygiene Student Scholarship

Problem: In terms of healthcare, the transgender population is underserved. Unfortunately, these individuals often experience stress related to seeking preventative care and fear discrimination. These factors preventing them from seeking care, in addition to hormone therapy taken during the transition process, could have severe impacts on their dental health. The purpose of this study is to establish a link between the hormone therapy used during gender transitioning and the effect on oral health. While there is a correlation between hormone replacement therapy and clinical evidence that sex hormones can impact on periodontal tissues, few studies have linked this knowledge to …

Microhemorrhages In Professional Motocross Athletes: A Case Series, Brianna Millsaps, Philip R. Worts, David C. Berg, Scott O. Burkhart

Faculty Publications - Doctor of Psychology (PsyD) Program

Introduction: Motocross is a sport in which riders race 250–450 cc four-stroke dirt bikes and are potential-ly subjected to a high frequency of head injuries starting at a very young age. The objective of this case series is to present the findings following gradient echo T2-weighted MRI (SWI) upon clinical evaluation after a concussion in 4 young professional motocross racers.

Clinical Findings: Microhemorrhages were found in 2 of 4 riders. Areas of microhemorrhages were not aligned with a previously positive CT finding from a prior concussion in 1 rider.

Conclusions: Microhemorrhages were found in 2 young motocross riders following a …

Regulating Physician-Assisted Suicide, Colm O'Connor

Online Blog

No abstract provided.

Ethics And Execution: Investigating The Death Penalty In Relation To Mental Health, Elizabeth Hall

Online Blog

No abstract provided.

Physical Fitness Improvements Of 8-Week Light Vs. Heavy Tyreflip Training In Young Adults, Del P. Wong, Anthony Weldon, Jake K. Ngo

Faculty of Management & Hospitality (THEi)

This study compared the effects of eight-week tyre flipping training intervention using light and heavy tyres on physical fitness performance. Twenty-nine young physically active males were divided into light (n = 15) and heavy (n = 14) tyre flipping groups evenly according to body weight and height. Body-to-tyre weight ratios were 0.61 ± 0.06 for the light tyre (LTTG) and 1.51 ± 0.16 for the heavy tyre training (HTTG) groups. Fitness parameters were measured before and after the intervention. One-way ANCOVA analysis indicated no significant between-group differences when pre-test values were controlled. Both groups demonstrated within-group improvements in 6RM bench …

European Heart Rhythm Association (Ehra) International Consensus Document On How To Prevent, Diagnose, And Treat Cardiac Implantable Electronic Device Infections - Endorsed By The Heart Rhythm Society (Hrs), The Asia Pacific Heart Rhythm Society (Aphrs), The Latin American Heart Rhythm Society (Lahrs), International Society For Cardiovascular Infectious Diseases (Iscvid) And The European Society Of Clinical Microbiology And Infectious Diseases (Escmid) In Collaboration With The European Association For Cardio-Thoracic Surgery (Eacts), C. Blomström-Lundqvist, V. Traykov, P. A. Erba, H. Burri, J. C. Nielsen, M. G. Bongiorni, J. Poole, G. Boriani, L. M. Epstein, E. Mangoni, +10 Additional Authors

Journal Articles

© 2019 The Author(s). Published by Oxford University Press on behalf of the European Society of Cardiology. Pacemakers, implantable cardiac defibrillators, and cardiac resynchronization therapy devices are potentially life-saving treatments for a number of cardiac conditions, but are not without risk. Most concerning is the risk of a cardiac implantable electronic device (CIED) infection, which is associated with significant morbidity, increased hospitalizations, reduced survival, and increased healthcare costs. Recommended preventive strategies such as administration of intravenous antibiotics before implantation are well recognized. Uncertainties have remained about the role of various preventive, diagnostic, and treatment measures such as skin antiseptics, pocket …

Inpatient Use Of Ambulatory Telemetry Monitors For Covid-19 Patients Treated With Hydroxychloroquine And/Or Azithromycin, D. Chang, M. Saleh, J. Gabriels, H. Ismail, B. Goldner, J. Willner, S. Beldner, R. Mitra, R. John, L. M. Epstein

Journal Articles

No abstract provided.

Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic., N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. Choi, M. K. Chung, G. Conte, L. M. Epstein, P. D. Varosy, +13 Additional Authors

Journal Articles

No abstract provided.

An Algorithm For Managing Qt Prolongation In Coronavirus Disease 2019 (Covid-19) Patients Treated With Either Chloroquine Or Hydroxychloroquine In Conjunction With Azithromycin: Possible Benefits Of Intravenous Lidocaine, R. L. Mitra, S. A. Greenstein, L. M. Epstein

Journal Articles

No abstract provided.

Challenges In The Interpretation And Application Of Typical Imaging Features Of Covid-19., Mm Hammer, Ca Raptis, Ts Henry, A Shah, S Bhalla, Md Hope

Journal Articles

No abstract provided.

Covid-19 Epidemic Peer Support And Crisis Intervention Via Social Media, P Cheng, G Xia, P Pang, B Wu, W Jiang, Y-T Li, M Wang, Q Ling, X Chang, X Bi, +3 Additional Authors

Journal Articles

No abstract provided.

Covid-19 In Children: More Than Meets The Eye, Sh F. Hagmann

Journal Articles

No abstract provided.

Educating Surgeons To Educate Patients About The Covid-19 Pandemic, A Saxena, M Bullock, Jr Danoff, Ds Rodd, Sj Fischer, Bm Stronach, Br Levine

Journal Articles

No abstract provided.

Time To Intra-Arrest Therapeutic Hypothermia In Out-Of-Hospital Cardiac Arrest Patients And Its Association With Neurologic Outcome: A Propensity Matched Sub-Analysis Of The Princess Trial, A. Awad, F. S. Taccone, M. Jonsson, S. Forsberg, J. Hollenberg, A. Truhlar, M. Ringh, B. S. Abella, L. B. Becker, P. Nordberg, +2 Additional Authors

Journal Articles

© 2020, The Author(s). Purpose: To study the association between early initiation of intra-arrest therapeutic hypothermia and neurologic outcome in out-of-hospital cardiac arrest. Methods: A prespecified sub-analysis of the PRINCESS trial (NCT01400373) that randomized 677 bystander-witnessed cardiac arrests to transnasal evaporative intra-arrest cooling initiated by emergency medical services or cooling started after hospital arrival. Early cooling (intervention) was defined as intra-arrest cooling initiated < 20 min from collapse (i.e., ≤ median time to cooling in PRINCESS). Propensity score matching established comparable control patients. Primary outcome was favorable neurologic outcome, Cerebral Performance Category (CPC) 1–2 at 90 days. Complete recovery (CPC 1) was among secondary outcomes. Results: In total, 300 patients were analyzed and the proportion with CPC 1–2 at 90 days was 35/150 (23.3%) in the intervention group versus 24/150 (16%) in the control group, odds ratio (OR) 1.92, 95% confidence interval (CI) 0.95–3.85, p =.07. In patients with shockable rhythm, CPC 1–2 was 29/57 (50.9%) versus 17/57 (29.8%), OR 3.25, 95%, CI 1.06–9.97, p =.04. The proportion with CPC 1 at 90 days was 31/150 (20.7%) in the intervention group and 17/150 (11.3%) in controls, OR 2.27, 95% CI 1.12–4.62, p =.02. In patients with shockable rhythms, the proportion with CPC 1 was 27/57 (47.4%) versus 12/57 (21.1%), OR 5.33, 95% CI 1.55–18.3, p =.008. Conclusions: In the whole study population, intra-arrest cooling initiated < 20 min from collapse compared to cooling initiated at hospital was not associated with improved favorable neurologic outcome. In the subgroup with shockable rhythms, early cooling was associated with improved favorable outcome and complete recovery.

Rapid Donor Identification Improves Survival In High-Risk First-Remission Patients With Acute Myeloid Leukemia, J. M. Pagel, M. Othus, G. Garcia-Manero, M. Fang, J. P. Radich, D. A. Rizzieri, G. Marcucci, S. A. Strickland, R. L. Bayer, F. R. Appelbaum, +10 Additional Authors

Journal Articles

PURPOSE: Patients with acute myeloid leukemia with high-risk cytogenetics in first complete remission (CR1) achieve better outcomes if they undergo allogeneic hematopoietic cell transplantation (HCT) compared with consolidation chemotherapy alone. However, only approximately 40% of such patients typically proceed to HCT. METHODS: We used a prospective organized approach to rapidly identify donors to improve the allogeneic HCT rate in adults with high-risk acute myeloid leukemia in CR1. Newly diagnosed patients had cytogenetics obtained at enrollment, and those with high-risk cytogenetics underwent expedited HLA typing and were encouraged to be referred for consultation with a transplantation team with the goal of …