Medicine and Health Sciences Commons^™

Retrospective Analysis Of The Association Of Non-Carious Cervical Lesions With Bruxism, Angelica J. Bustos, Tanya Al-Talib, Neamat H. Abubakr

Dental Medicine Faculty Research

Recently, bruxism became the center of attention for the etiological research of non-carious cervical lesions (NCCLs). The present study aims to investigate the presence and types of NCCLs associated with bruxism. Retrospective keywords search of the clinical notes of all patient charts in axiUmTM was performed using the terms “bruxism”, “attrition”, “abrasion”, “erosion”, and “abfraction”. All bruxer patients 18 years and older who presented to the UNLV School of Dental Medicine (01/01/2014 to 09/30/2018) with the complete record were included. To determine the statistical analysis implications, the chi-square test was used. Commonest types of NCCL associated with bruxism were attrition …

Short Treatment With Antalarmin Alters Adrenal Gland Receptors In The Rat Model Of Endometriosis, Annelyn Torres-Reveron, Maahrose Rana, Varesh Gorabi, Leslie L. Rivera-Lopez, Caroline B. Appleyard

Health & Biomedical Sciences Faculty Publications

Endometriosis is a chronic inflammatory disorder in which endometrial tissue is found outside the uterine cavity. Previous reports suggest that there is a dysregulation of the hypothalamic pituitary adrenal axis during the progression of endometriosis. Our previous report showed that a short-term treatment with antalarmin, a corticotrophin releasing hormone receptor type 1 (CRHR1) antagonist decreases the number and size of endometriotic vesicles in the auto-transplantation rat model of endometriosis. Our current goal was to examine the mRNA expression of intra-adrenal receptors to better understand the mechanisms of the hypothalamic pituitary adrenal (HPA) axis involvement in endometriosis. We used two groups …

Assessment Of Outcomes And Novel Immune Biomarkers In Metaplastic Breast Cancer: A Single Institution Retrospective Study., Evan Morgan, Anupama Suresh, Akaansha Ganju, Daniel G Stover, Robert Wesolowski, Sagar Sardesai, Anne Noonan, Raquel Reinbolt, Jeffrey Vandeusen, Nicole Williams, Mathew A Cherian, Zaibo Li, Gregory Young, Marilly Palettas, Julie Stephens, Joseph Liu, Amanda Luff, Bhuvaneswari Ramaswamy, Maryam Lustberg

Women’s Health Articles

BACKGROUND: Metaplastic breast cancer remains poorly characterized given its rarity and heterogeneity. The majority of metaplastic breast cancers demonstrate a phenotype of triple-negative breast cancer; however, differences in clinical outcomes between metaplastic breast cancer and triple-negative breast cancer in the era of third-generation chemotherapy remain unclear.

METHODS: We compared the clinical outcomes between women with metaplastic breast cancer and women with triple-negative breast cancer diagnosed between 1994 and 2014. Metaplastic breast cancer patients were matched 1:3 to triple-negative breast cancer patients by stage and age at diagnosis. Distant disease-free survival (DDFS) and overall survival (OS) were estimated using Kaplan Meier …

Early-Morning And Late-Night Maximal Runs: Metabolic And Perceived Exertion Outcomes, Jenna L. Carducci, Matthew J. Garver, Whitley J. Stone, Meera Penumetcha, Dustin W. Davis, Nicolas M. Philipp, Josie N. Hair

Topics in Exercise Science and Kinesiology

• People may exercise at the ends of their day to fit activity into their schedule; the purpose of this investigation was to determine if metabolic or perceived exertion outcomes differed between maximal runs early in the morning and late at night.
• After consuming a standardized, glucose drink, thirteen recreationally active individuals completed an early-morning and a late-night run on the treadmill while researchers measured metabolic (aerobic capacity and substrate usage) and perceived exertion outcomes.
• Point of application #1: Aerobic capacity (maximal consumption of oxygen) and the usage of fat as a fuel to support energy production during exercise were …

Guidelines For Reviewers: Topics In Exercise Science And Kinesiology, James W. Navalta, Donald L. Hoover, Robert Salatto, Whitley J. Stone, Scott Lyons Phd

Topics in Exercise Science and Kinesiology

• The purpose of this document is to serve as a guide for evaluators who agree to review work submitted to Topics in Exercise Science and Kinesiology.
• To assist evaluators, a Reviewer Rubric has been created with the following sections: Title Page and Abstract, Introduction and Methods Page, Point of Application Page(s), Other Considerations, and Reviewer Decisions.
• Point of application: Reviewing the Title and Abstract page – rubric shared for title, author list, affiliations, the abstract, and key words.
• Point of application: Reviewing the Introduction and Methods page – evaluation of introductory paragraph, paragraph for methodology and/or results.
• Point of …

Effects Of Deceptive Footwear Condition On Subjective Comfort And Running Biomechanics, Zoe Y.S. Chan, Ivan P.H. Au, Janet H. Zhang-Lea, Reed Ferber, Gary Shum, Winko W. An, Roy T.H. Cheung

Human Physiology Faculty Scholarship

Comfort is a major criterion for footwear selection. Previous studies have suggested that physical properties were not enough to predict comfort and psychological factors could also affect the perception. To understand comfort, this study examined the effect of controlled shoe description and price cue on the perception of comfort. Furthermore, this study also examined the running biomechanics in response to footwear conditions of differing comfort. Fifteen runners completed treadmill running tests in two conditions: Shoe A and Shoe B. The same pair of neutral running shoes was used in both conditions, yet, Shoe B was described to be the “latest …

What's Happening: January 13, 2020, Maine Medical Center

What's Happening

No abstract provided.

Comprehensive Pharmacy Practice And Patient Care Php 548, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Week Of January 13, 2020, New York Medical College

InTouch

• Ira J. Bedzow, Ph.D., is Named UNESCO Chair of Bioethics
• Department of Surgery Hosts Sixteenth Annual Louis R.M. Del Guercio, M.D., Distinguished Visiting Professorship and Research Day
• Graduate Student Association Aims to Enhance Student Life
• Center for Disaster Medicine Hosts Pediatric Focused Disaster Response Training

Antiproliferative And Apoptotic Effects Of Proteins From Black Seeds (Nigella Sativa) On Human Breast Mcf-7 Cancer Cell Line, Yamna Khursid, Basir Syed, Shabana U. Simjee, Obaid Beg, Aftab Ahmed

Pharmacy Faculty Articles and Research

Background

Nigella sativa (NS), a member of family Ranunculaceae is commonly known as black seed or kalonji. It has been well studied for its therapeutic role in various diseases, particularly cancer. Literature is full of bioactive compounds from NS seed. However, fewer studies have been reported on the pharmacological activity of proteins. The current study was designed to evaluate the anticancer property of NS seed proteins on the MCF-7 cell line.

Methods

NS seed extract was prepared in phosphate-buffered saline (PBS), and proteins were precipitated using 80% ammonium sulfate. The crude seed proteins were partially purified using gel filtration …

Planning A ‘Dancing At The Vatican’ Screening To Celebrate The Global Huntington's Disease Community's Journey, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Novel Histological Index For Evaluation Of Environmental Enteric Dysfunction Identifies Geographic-Specific Features Of Enteropathy Among Children With Suboptimal Growth, Ta-Chiang Liu, Kelley Vanbuskirk, Syed Asad Ali, M. Paul Kelly, Lori R. Holtz, Omer H. Yilmaz, Kamran Sadiq, Najeeha Talat Iqbal, Beatrice Amadi, Sana Syed

Department of Paediatrics and Child Health

Background: A major limitation to understanding the etiopathogenesis of environmental enteric dysfunction (EED) is the lack of a comprehensive, reproducible histologic framework for characterizing the small bowel lesions. We hypothesized that the development of such a system will identify unique histology features for EED, and that some features might correlate with clinical severity.
Methods: Duodenal endoscopic biopsies from two cohorts where EED is prevalent (Pakistan, Zambia) and North American children with and without gluten sensitive enteropathy (GSE) were processed for routine hematoxylin & eosin (H&E) staining, and scanned to produce whole slide images (WSIs) which we shared among study pathologists …

Hypercholesterolemia Accelerates Both The Initiation And Progression Of Angiotensin Ii-Induced Abdominal Aortic Aneurysms, Jing Liu, Hisashi Sawada, Deborah A. Howatt, Jessica J. Moorleghen, Olga A. Vsevolozhskaya, Alan Daugherty, Hong S. Lu

Pharmacology and Nutritional Sciences Faculty Publications

Objective: This study determined whether hypercholesterolemia would contribute to both the initiation and progression of angiotensin (Ang)II-induced abdominal aortic aneurysms (AAAs) in mice.

Methods and Results: To determine whether hypercholesterolemia accelerates the initiation of AAAs, male low-density lipoprotein (LDL) receptor -/- mice were either fed one week of Western diet prior to starting AngII infusion or initiated Western diet one week after starting AngII infusion. During the first week of AngII infusion, mice fed normal diet had less luminal expansion of the suprarenal aorta compared to those initiated Western diet after the first week of AngII infusion. The two groups …

Trends In Mental Well-Being Of Non-Hispanic White Children Of Midlife Parents With Low Education, Neeraj Bhandari

School of Public Health Faculty Research

Background: It is unknown whether recent increase in mortality and morbidity linked to mental despair (eg, suicide, opioid addiction, alcoholism) in midlife non-Hispanic whites (NHWs) was accompanied by declines in mental well-being of NHW children. The author examined aggregate trends in the mental well-being of NHW children between 2003 and 2018. Methods: The author used linear (unadjusted) regression to generate estimates of long period (ie, between 2003-2005 and 2016-2018) and annual change in mental well-being and self-assessed health from the National Health Interview Survey data on 68 057 NHW children (aged 4-17 years). Results: The NHW children showed no significant …

Population Council Annual Evaluation Report: Opening Futures (Abriendo Futuros) For Indigenous Girls In Yucatan, Mexico, Silvana Larrea

Poverty, Gender, and Youth

This Population Council Annual Evaluation Report includes evaluation activities from December 1, 2015 to December 1, 2019, and future evaluation plans (2019–21), as part of the Opening Futures (Abriendo Futuros) project for indigenous girls in Yucatan, Mexico. The first section describes the finalized analysis of the impact evaluation of the pilot phase; the second section reports the progress of evaluation activities; and the third section includes an evaluation of future plans for the period December 1, 2019 to November 30, 2021.

Rankl/Rank Promotes The Migration Of Gastric Cancer Cells By Interacting With Egfr, Xing Wan, Yongxi Song, Honghong Fang, Ling Xu, Xiaofang Che, Shuo Wang, Xiaomeng Zhang, Lingyun Zhang, Ce Li, Yibo Fan, Kezuo Hou, Zhi Li, Xueqing Wang, Yunpeng Liu, Xiujuan Qu

Research outputs 2014 to 2021

BACKGROUND: The incidence and mortality rates of gastric cancer (GC) rank in top five among all malignant tumors. Chemokines and their receptor-signaling pathways reportedly play key roles in the metastasis of malignant tumor cells. Receptor activator of nuclear factor κB ligand (RANKL) is a member of the tumor necrosis factor family, with strong chemokine-like effects. Some studies have pointed out that the RANKL/RANK pathway is vital for the metastasis of cancer cells, but the specific mechanisms in GC remain poorly understood. RESULTS: This study reports original findings in cell culture models and in patients with GC. Flow cytometry and western …

Computer-Assisted Planning For Minimally Invasive Anterior Two-Thirds Laser Corpus Callosotomy: A Feasibility Study With Probabilistic Tractography Validation., Vejay N. Vakharia, Rachel E. Sparks, Sjoerd B. Vos, Yarema Bezchlibnyk, Ashesh D. Mehta, Jon T. Willie, Chengyuan Wu, Ashwini Sharan, Sebastien Ourselin, John S Duncan

Department of Neurosurgery Faculty Papers

BACKGROUND: Anterior two-thirds corpus callosotomy is an effective palliative neurosurgical procedure for drug-refractory epilepsy that is most commonly used to treat drop-attacks. Laser interstitial thermal therapy is a novel stereotactic ablative technique that has been utilised as a minimally invasive alternative to resective and disconnective open neurosurgery. Case series have reported success in performing laser anterior two-thirds corpus callosotomy. Computer-assisted planning algorithms may help to automate and optimise multi-trajectory planning for this procedure.

OBJECTIVE: To undertake a simulation-based feasibility study of computer-assisted corpus callostomy planning in comparison with expert manual plans in the same patients.

METHODS: Ten patients were selected …

Using Mobile Phones To Improve Community Health Workers Performance In Low-And-Middle-Income Countries, Anam Shahil Feroz, Rawshan Jabeen, Sarah Saleem

Community Health Sciences

Background: In low-and-middle-income countries community health workers are the core component of the PHC system as they act as a liaison between the communities and the healthcare facilities. Evidence suggests that the services offered by these workers have helped in the decline of maternal and child morbidity and mortality rates and the burden of communicable and non-communicable diseases. However, the coverage and the overall progress towards achieving the SDG targets is very sluggish. The recent consensus concerning this current pace of progress, is that it relates to financial and human resources constraints. CHWs are overburdened as they are expected to …

Increased Episodes Of Aspiration On Videofluoroscopic Swallow Study In Children With Nasogastric Tube Placement., Sarah T. Edwards, Linda Ernst, Ashley K. Sherman, Ann M. Davis

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Given the limited evidence available, the impact of nasogastric (NG) tube placement on swallowing in children is not well understood. When a child needs to be fed enterally, the current standard is to initially place an NG tube and leave it in place for the first few months of supplemental or total enteral nutrition. It is important to understand if placement of NG tubes has a negative effect on a patient's swallow.

METHODS: We retrospectively reviewed the charts of those children who had videofluoroscopic swallow studies (VFSS) to identify all children who had an NG tube in place at …

Why Do Women Deliver Where They Had Not Planned To Go? A Qualitative Study From Peri-Urban Nairobi Kenya., V. Naanyu, V. Mujumdar, C. Ahearn, M. Mcconnell, J. Cohen

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: In urban Kenya, couples face a wide variety of choices for delivery options; however, many women end up delivering in different facilities from those they had intended while pregnant. One potential consequence of this is delivering in facilities that do not meet minimum quality standards and lack the capacity to provide treatment for obstetric and neonatal complications.

METHODS: This study investigated why women in peri-urban Nairobi, Kenya deliver in facilities they had not intended to use. We used 60 in-depth audio-recorded interviews in which mothers shared their experiences 2-6 months after delivery. Descriptive statistics were used to summarize socio-demographic …

Analyses Of The 2019 Nobel Prize In Physiology Or Medicine: Molecular Machinery For Cellular Oxygen Level Response, Neyda V. Gilman

Library Scholarship

Gregg L. Semenza, William G Kaelin, Jr, and Sir Peter J. Ratcliffe were awarded the 2019 Nobel Prize for Physiology or Medicine on October 7, 2019. Their work led to the understanding of how cells recognize and adapt to varying oxygen levels. Hypoxia-inducible nuclear factors play an essential role in this mechanism by turning on other genes that work towards increasing oxygen levels in hypoxic environments. Other vital pieces of the machinery include von Hippel-Lindau proteins and prolyl hydroxylation. Due to the necessity of oxygen in numerous human physiological systems, this discovery will likely have nearly immeasurable impacts on human …

Research With Novel Technology: Advances In Concussion Diagnosis And Mouthpiece Utilization During Performance, Dena P. Garner

Journal of the South Carolina Academy of Science

No abstract provided.

Medical School Watercooler Newsletter - January 12, 2020, Lindsey Lyle

Watercooler Newsletter

This is the January 12, 2020 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Basic Medical Sciences alumna prepares for World Marathon Challenge
• USA Health Basketball Game Day set for Jan. 18
• Cook retires after four decades of service to USA College of Medicine
• A day in the life of a postdoctoral research fellow
• Pathology to host Research Seminar Series Jan. 16
• Satisfaction high among USA College of Medicine graduates

Postpartum Depression! One Iv And I Am Back To Happy!, Gabrielle Dubruille

All Publications

No abstract provided.

Medical Marijuana High On Drug Interaction, Shahrzad Ghanavi

All Publications

No abstract provided.

Lgbt – Gender Identification And Pharmacist Approach To Care Of The Patient, Alexandra Angel

All Publications

No abstract provided.

What A Blood Bath! Andexxa® Makes A Splash! Current Trends In Anticoagulation Reversal, Marianela Robainas

All Publications

No abstract provided.

Update On Oral Oncolytics, Elizabeth Osmon

All Publications

No abstract provided.

What A Blood Bath! Andexxa® Makes A Splash! Current Trends In Anticoagulation Reversal, Michael Pasqualicchio

All Publications

No abstract provided.

Precautions & Handling Of Hazardous Chemotherapeutic Agents, Paula Sayegh

All Publications

No abstract provided.