Medicine and Health Sciences Commons^™

Development And Characterization Of A Wee1 Kinase Degrader, Zhengnian Li, Benika J Pinch, Calla M Olson, Katherine A Donovan, Radosław P Nowak, Caitlin E Mills, David A Scott, Zainab M Doctor, Nicholas A Eleuteri, Mirra Chung, Peter K Sorger, Eric S Fischer, Nathanael S Gray

Faculty, Staff and Students Publications

The G1/S cell cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Wee1 regulates the G2/M checkpoint by phosphorylating CDK1 at Tyr15 to prevent mitotic entry. Previous drug development efforts targeting Wee1 resulted in the clinical-grade inhibitor, AZD1775. However, AZD1775 is burdened by dose-limiting adverse events, and has off-target PLK1 activity. In an attempt to overcome these limitations, we developed Wee1 degraders by conjugating AZD1775 to the cereblon (CRBN)-binding ligand, pomalidomide. The resulting lead compound, ZNL-02-096, degrades Wee1 while sparing PLK1, induces G2/M accumulation at 10-fold lower doses …

Quilting And Sharing: Promoting Lifelong Learning And Service To Others, Jennifer Fortuna

The Open Journal of Occupational Therapy

Lynne Hall, an occupational therapist, educator, and quilter based in Kalamazoo, MI, provided the cover art for the Winter 2020 issue of The Open Journal of Occupational Therapy (OJOT). “Four Patch Posy” is a 45” x 55” quilt made from cotton. In her 50th year of occupational therapy practice, Lynne’s philosophy is rooted in lifelong learning and service to others. The quilt aesthetic provides Lynne a creative medium to serve in her community. With her person-centered approach, Lynne facilitates human potential in the clients, students, and community members she serves. Success in both occupational therapy practice and quilting require a …

Developing Tailored Program Proposals For Occupational Therapy In Primary Care, Katie Smith, Mackenzie Day, Sherry Muir, Sue Dahl-Popolizio

The Open Journal of Occupational Therapy

No abstract provided.

Self-Regulation As Key Factor In Protection Against The Harmful Effects Of Adverse Childhood Experiences: Critical Role For Occupational Therapists, Rondalyn Whitney

The Open Journal of Occupational Therapy

No abstract provided.

Comparing Learning Platform Impact On Low Vision Education For Occupational Therapists, Jaimee D. Perea, William Sit

The Open Journal of Occupational Therapy

This pilot study examines the impact of face-to-face, remote, and hybrid learning platforms on satisfaction, confidence, and knowledge-application of occupational therapy practitioners during a synchronous low vision continuing education program. Fifteen participants were divided into three groups, each corresponding to one learning platform. They engaged in two 45-min learning sessions and completed pre, post, and follow-up surveys to measure the impact of the learning platform on the dependent variables of satisfaction, confidence, and knowledge application. No significant differences were found between learning platforms for the three variables, but improvements from pre to follow-up survey were found to be significant for …

Master’S And Doctoral Occupational Therapy Students’ Perceptions Of Research Integration In Their Programs, Jeffrey Sargent, Ashley Wermers, Lauren Russo, Kristin Valdes

The Open Journal of Occupational Therapy

This is a pilot study with the intent of identifying occupational therapy doctorate (OTD) and master’s (MOT) students’ perceptions of research in their coursework. A cross-sectional study was conducted through a survey of OTD and MOT students. The Student Perception of Research Integration Questionnaire (SPRIQ) was emailed to graduate occupational therapy programs in the United States. An unpaired single tailed t-test was used to compare the mean scores between the MOT and OTD student responses for each scale and subscale. Two hundred and twenty-six students filled out the questionnaire. Both the OTD and MOT students had a favorable perception …

A Personal Perspective On Daily Occupations To Counteract Cancer Related Fatigue: A Case Study, Sheila M. Longpre', Katie M. Polo, Mary F. Baxter

The Open Journal of Occupational Therapy

Background: This case study aimed to identify and describe meaningful physical occupations used by a cancer survivor to increase or maintain levels of participation during active chemotherapy and subsequent cancer related fatigue.

Method: A case study approach was used to develop an in-depth description and analysis based on one participant’s experience with breast cancer and associated treatments. A semi-structured interview was conducted. The data were analyzed through description of the case, categories, and themes. It also included categorical aggregation in efforts to seek a collection of instances from the data to explore any issue-relevant meanings.

Results: Following …

Defining Mobile Tech Posture: Prevalence And Position Among Millennials, Nathan Short, Michelle Mays, Alex Cool, Ariana Delay, Ali Lannom, Laryn O'Donnell, Ruth Stuber

The Open Journal of Occupational Therapy

Background: Mobile technologies have revolutionized daily life, significantly impacting ADLs and IADLs, as well as use of the hand and upper extremity. The primary objectives of this study are to (a) provide a formal goniometric description of mobile tech posture and (b) examine the prevalence of this sub-optimal posture among a group of graduate students.

Method: This study used a cross-sectional study design. Comprehensive goniometric measurements of the neck and upper extremity were taken with participants (N = 46) using their mobile devices while texting or using the Internet. Handheld usage data from the iPhone Screen Time …

Mapping Occupational Therapy Practice With Postsecondary Students: A Scoping Review, Karen M. Keptner, Karen Mccarthy

The Open Journal of Occupational Therapy

Background: Legislation supports a role for occupational therapy in postsecondary settings, but this area is not a common practice area and the practice area is not well understood. This scoping review maps current literature of occupational therapists working with students in postsecondary settings in order to inform future research and practice.

Method: After identifying included articles, a narrative description of the quantitative studies along with a concept map were completed. A qualitative thematic analysis of the articles was also conducted.

Results: Twenty-five articles met the inclusion criteria. Quantitative results describe occupational therapy services as both a direct …

Sensory Processing Patterns And Internalizing Behaviors In The Pediatric And Young Adult General Population: A Scoping Review, Kasey Kotsiris, Jennifer Westrick, Lauren Little

The Open Journal of Occupational Therapy

Background: While research has largely focused on the relationship between sensory processing patterns and internalizing behaviors (e.g., anxiety, depression) in children with autism spectrum disorder or attention deficit hyperactivity disorder, this relationship is not fully understood among the general population or across development.

Method: This scoping review addressed the following research question: How are sensory processing patterns associated with internalizing behaviors (e.g., anxiety, depression) among children with various conditions as well as typically developing children from birth to 22 years of age?

Results: Since 2005, n = 97 peer-reviewed articles have addressed this topic and were included …

Scoping Review Of Interventions To Promote Social Participation In Adolescents And Young Adults With Neurodisability, Conall O'Rourke, Mark Linden, Gary Bedell

The Open Journal of Occupational Therapy

Background: Social participation, described as taking part in, being involvement and engaged with, and doing or being with others, is an important health outcome. Adolescents and young adults with neurodisability are often restricted in their social participation, particularly if they experience social and executive functioning challenges. A scoping review was conducted to examine interventions aimed at improving social participation in adolescents and young adults with neurodisability characterized by these challenges.

Method: The scoping review included peer-reviewed empirical studies published from 1990 to 2016 that employed psychosocial interventions to improve social participation in young people 13 to 24 years …

Schizophrenia Spectrum Disorders: Linking Motor And Process Skills, Sensory Patterns, And Psychiatric Symptoms, Lola Halperin, Janet Falk-Kessler

The Open Journal of Occupational Therapy

Background: Consistent evidence suggests sensory abnormalities and skill deficits in people with Schizophrenia Spectrum Disorder (SSD). Further exploration of their sensory patterns and performance skills is warranted to promote community participation among these individuals.

Method: This study examined sensory patterns and motor and process skills in relationship to psychiatric symptoms in adult patients with SSD. Participants were evaluated using the Adolescent/Adult Sensory Profile, the Assessment of Motor and Process Skills, and the Brief Psychiatric Rating Scale.

Results: Of the 18 participants, the majority showed sensory differences, deficits in motor and process skills, and the presence of moderate …

State Of The Journal: 400,000 And Growing, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

Augmenting The Pressure-Based Pasteurization Of Listeria Monocytogenes By Synergism With Nisin And Mild Heat, Sadiye Aras, Md Niamul Kabir, Shahid Chowdhury, Aliyar Cyrus Fouladkhah

Agricultural and Environmental Sciences Faculty Research

The current study investigated Listeria monocytogenes inactivation using mild heat with elevated hydrostatic pressure and nisin under buffered condition. A four-strain pathogen mixture was exposed to 0 (control) and up to 9 min of (1) 4 °C elevated pressure; (2) 4 °C elevated pressure and nisin; (3) 4 °C nisin; (4) heat at 40 °C; (5) 40 °C elevated pressure; (6) 40 °C elevated pressure and nisin; and (7) 40 °C nisin. Elevated hydrostatic pressure at 400 MPa (Hub880 Explorer, Pressure BioScience Inc., Easton, MA, USA) and nisin concentration of 5000 IU/mL were used in the trials. Analyses of variance …

Flexor Tenotomy For The Treatment Of Hallux Ulcers, Nathalia Esmeral, Val E. Haddon, Chase G. Dahl, Erin Lewis, David Khakshoor

Podiatry

Aims: To assess and evaluate the relationship between flexor tenotomies in a clinical setting and the time course for healing neuropathic, diabetic and structural deformity hallux ulcers.

Methods: This retrospective study analyzes the medical files of 1,471 patients treated for digital foot ulcers by flexor tenotomies between September 2011 and January 2019. For the intent of this particular research, focus was preserved towards the effect of flexor tenotomy on healing time to address hallux ulcers. A total of 97 patients between the ages of 41 and 86 years old underwent flexor tenotomy for the treatment of hallux ulcers with a …

Comparison Of Blood Lactate And Perceived Exertion Responses In Two Matched Time-Under- Tension Protocols, Salvador Vargas-Molina, Fernando Martín-Rivera, Diego A. Bonilla, Jorge L. Petro, Leandro Carbone, Ramón Romance, Manuel Dediego, Brad J. Schoenfeld, Javier Benítez-Porres

Publications and Research

Purpose: The aim of this study was to compare the concentration of blood lactate [bLa-] and the subjective perception of exertion of trained men in a moderate repetition protocol (MRP) versus a high repetition protocol (HRP) equated for time under tension.

Methods: A sample of 40 healthy young men (aged, 23.2 ± 4.0 years; height, 177.3 ± 7.0 cm; BMI, 24.3 ± 2.2) performed two sessions of 8 sets of bicep curls with a one-week recovery interval between the trials. In the HRP protocol, 20 repetitions were performed with a cadence of 2 seconds of eccentric and 1 …

Social, Economic, And Political Events Affect Gender Equity In China, Nepal, And Nicaragua: A Matched, Interrupted Time-Series Study, Tuan T. Nguyen, Ashley Darnell, Amy Weissman, Edward A. Frongillo Jr., Roger Mathisen, Karin Lapping, Timothy D. Mastro, Mellissa Withers

Faculty Publications

: Progress in gender equity can improve health at the individual and country levels.: This study's objective was to analyze recent trends in gender equity and identify historical and contextual factors that contributed to changes in gender equity in three countries: China, Nepal, and Nicaragua.: To assess gender equity trends, we used the Gender Gap Index (GGI) from the World Economic Forum's Global Gender Gap Report (2006-2017). The GGI incorporated data on economic participation, educational attainment, health, and political empowerment for almost 150 countries. We selected China, Nepal, and Nicaragua because of their major changes in GGI and diversity in …

Biogeographic Study Of Human Gut-Associated Crassphage Suggests Impacts From Industrialization And Recent Expansion, Tanvi P/ Honap, Krithivasan Sankaranarayanan, Stephanie L. Schnorr, Andrew T. Ozga, Christina Warinner, Cecil M. Lewis Jr.

Anthropology Faculty Research

CrAssphage (cross-assembly phage) is a bacteriophage that was first discovered in human gut metagenomic data. CrAssphage belongs to a diverse family of crAss-like bacteriophages thought to infect gut commensal bacteria belonging to Bacteroides species. However, not much is known about the biogeography of crAssphage and whether certain strains are associated with specific human populations. In this study, we screened publicly available human gut metagenomic data from 3,341 samples for the presence of crAssphage sensu stricto (NC_024711.1). We found that crAssphage prevalence is low in traditional, hunter-gatherer populations, such as the Hadza from Tanzania and Matses from Peru, as compared to …

Combining Fmri During Resting State And An Attention Bias Task In Children, Anita Harrewijn, Rany Abend, Julia Linke, Melissa A. Brotman, Nathan A. Fox, Ellen Leibenluft, Anderson M. Winkler, Daniel Samuel Pine

School of Medicine Publications

Neuroimaging studies typically focus on either resting state or task-based fMRI data. Prior research has shown that similarity in functional connectivity between rest and cognitive tasks, interpreted as reconfiguration efficiency, is related to task performance and IQ. Here, we extend this approach from adults to children, and from cognitive tasks to a threat-based attention task. The goal of the current study was to examine whether similarity in functional connectivity during rest and an attention bias task relates to threat bias, IQ, anxiety symptoms, and social reticence. fMRI was measured during resting state and during the dot-probe task in 41 children …

Simulated Patient's Feedback To Improve Communication Skills Of Clerkship Students, Ayesha Aleem Qureshi, Tabassum Zehra

Department for Educational Development

Background: The changing trends of the society and revisions to medical education have changed the way medical students are trained to adroitly care for patients hence, patient centered care has become need of today's society and communication skills are imperative in developing patient physician relationship. Increasingly, simulations are being used to aid medical students to incorporate theoretical knowledge into practice. There are innumerable studies regarding communication skills in terms of reliability, validity and feasibility but no such study has been documented using simulated patient's feedback in improving communication skills in Pakistan. The aim of this study is to explore whether …

An Experimental Analysis Of Voice Volume For Children With Autism Spectrum Disorder, Arturo Garcia

Thesis Projects

Inappropriate prosodic production is an often observed, but rarely treated, communication skill deficit for individuals with autism. Expanding on previous literature, we conducted a functional analysis on the voice volume responses (VVR) of two children with ASD utilizing similar procedures to those from Edgerton and Wine (2017). Further, we evaluated the efficacy of using visual feedback from an app and a function-based treatment to decrease inappropriate VVR and increase appropriate VVR. Results of the functional analysis indicated loud VVR was maintained by social negative reinforcement (escape from demands) for one participant and by both social negative and automatic reinforcement for …

January 2020, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Us Trends Of Opioid-Use Disorders And Associated Factors Among Hospitalized Patients With Spinal Conditions And Treatment From 2005 To 2014, Se Won Lee, Jay Shen, Sun Jung Kim, Sung-Youn Chun, Pearl Kim, Jahan Riaz, Ji Won Yoo, Jinwook Hwang

School of Public Health Faculty Research

Study Design: Serial cross-sectional study utilizing the National Inpatient Sample (NIS) 2005 to 2014. Objective: The aim of this study was to examine the trends of opioid-use disorders among hospitalized patients with spinal conditions and treatment and to identify its contributing factors. Summary of Background Data: The opioid is widely used in chronic spinal conditions, and misuse of prescriptions is the main culprit of the opioid crisis. Cannabis, the most commonly utilized illicit drug, has recently been substituted for opioid despite increasing cannabis-use emergency room visits. There is limited information on opioid-use disorders, the association with cannabis, and other contributing …

Post-War Environmental Pollution As A Risk Factor Of Congenital Disorders In Iraq: A Study Review: Post-War Environmental Pollution As A Risk Factor Of Congenital Disorders In Iraq: A Study Review, Muna Al-Hamdany

Iraqi National Journal of Medicine

Background: Several years of war with the recent terrorist conflicts have cumulatively affected Iraq’s land, air, water, and health infrastructure, and a substantial rise in the incidence of congenital defects has been reported in the period following the Gulf War in 1991, which was principally accredited to the environmental contamination by depleted uranium._x000D_ Aim: The aim is to review some published works of literature that are specifically concerned with environmental pollution after the war in Iraq as a possible risk factor for developmental disorders._x000D_ Patients and Methods: In addition to the published articles, this review includes direct descriptive data of …

Expression Of Cytokines And Chemokines As Predictors Of Stroke Outcomes In Acute Ischemic Stroke, Sarah R. Martha, Qiang Cheng, Justin F. Fraser, Liyu Gong, Lisa A. Collier, Stephanie M. Davis, Doug Lukins, Abdulnasser Alhajeri, Stephen Grupke, Keith R. Pennypacker

Institute for Biomedical Informatics Faculty Publications

Introduction: Ischemic stroke remains one of the most debilitating diseases and is the fifth leading cause of death in the US. The ability to predict stroke outcomes within the acute period of stroke would be essential for care planning and rehabilitation. The Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC; clinicaltrials.gov NCT03153683) study collects arterial blood immediately distal and proximal to the intracranial thrombus at the time of mechanical thrombectomy. These blood samples are an innovative resource in evaluating acute gene expression changes at the time of ischemic stroke. The purpose of this study was to identify inflammatory genes and …

Diverse Approaches To Predicting Drug-Induced Liver Injury Using Gene-Expression Profiles, G. Rex Sumsion, Michael S. Bradshaw Iii, Jeremy T. Beales, Emi Ford, Griffin R. G. Caryotakis, Daniel J. Garrett, Emily D. Lebaron, Ifeanyichukwu O. Nwosu, Stephen R. Piccolo

Faculty Publications

Drug-induced liver injury (DILI) is a serious concern during drug development and the treatment of human disease. The ability to accurately predict DILI risk could yield significant improvements in drug attrition rates during drug development, in drug withdrawal rates, and in treatment outcomes. In this paper, we outline our approach to predicting DILI risk using gene-expression data from Build 02 of the Connectivity Map (CMap) as part of the 2018 Critical Assessment of Massive Data Analysis CMap Drug Safety Challenge.

2020 January 14 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Foxd3 Regulates Vista Expression In Melanoma., Sheera R. Rosenbaum, Meghan Knecht, Mehri Mollaee, Zhijiu Zhong, Dan A. Erkes, Peter A. Mccue, Chervoneva, Adam C. Berger, Jennifer A. Lo, David E. Fisher, Jeffrey E. Gershenwald, Michael A. Davies, Timothy J. Purwin, Andrew E. Aplin

Department of Cancer Biology Faculty Papers

Immune checkpoint inhibitors have improved patient survival in melanoma, but the innate resistance of many patients necessitates the investigation of alternative immune targets. Many immune checkpoint proteins lack proper characterization, including V-domain Ig suppressor of T cell activation (VISTA). VISTA expression on immune cells can suppress T cell activity; however, few studies have investigated its expression and regulation in cancer cells. In this study, we observe that VISTA is expressed in melanoma patient samples and cell lines. Tumor cell-specific expression of VISTA promotes tumor onset in vivo, associated with increased intratumoral T regulatory cells, and enhanced PDL-1 expression on tumor-infiltrating …

Outcomes In Pediatric Studies Of Medium-Chain Acyl-Coa Dehydrogenase (Mcad) Deficiency And Phenylketonuria (Pku): A Review., Michael Pugliese, Kylie Tingley, Andrea Chow, Nicole Pallone, Maureen Smith, Alvi Rahman, Pranesh Chakraborty, Michael T Geraghty, Julie Irwin, Laure Tessier, Stuart G Nicholls, Martin Offringa, Nancy J Butcher, Ryan Iverson, Tammy J Clifford, Sylvia Stockler, Brian Hutton, Karen Paik, Jessica Tao, Becky Skidmore, Doug Coyle, Kathleen Duddy, Sarah Dyack, Cheryl R Greenberg, Shailly Jain Ghai, Natalya Karp, Lawrence Korngut, Jonathan Kronick, Alex Mackenzie, Jennifer Mackenzie, Bruno Maranda, John J Mitchell, Murray Potter, Chitra Prasad, Andreas Schulze, Rebecca Sparkes, Monica Taljaard, Yannis Trakadis, Jagdeep Walia, Beth K Potter

Paediatrics Publications

BACKGROUND: Inherited metabolic diseases (IMDs) are a group of individually rare single-gene diseases. For many IMDs, there is a paucity of high-quality evidence that evaluates the effectiveness of clinical interventions. Clinical effectiveness trials of IMD interventions could be supported through the development of core outcome sets (COSs), a recommended minimum set of standardized, high-quality outcomes and associated outcome measurement instruments to be incorporated by all trials in an area of study. We began the process of establishing pediatric COSs for two IMDs, medium-chain acyl-CoA dehydrogenase (MCAD) deficiency and phenylketonuria (PKU), by reviewing published literature to describe outcomes reported by authors, …

Nutrition Intervention Using Behavioral Change Communication Without Additional Material Inputs Increased Expenditures On Key Food Groups In Bangladesh, Andrea M. Warren, Edward A. Frongillo, Phuong H. Nguyen, Purnima Menon

Faculty Publications

Background

Behavioral change communication (BCC) promotes skills and knowledge to improve infant and young child feeding, but without additional material inputs, recipients must develop strategies to translate knowledge into action. Using data from the Alive & Thrive initiative in Bangladesh (2010–2014), we aimed to test whether households receiving the intensive intervention (opposed to the nonintensive intervention) increased expenditures on key foods for mothers and children (e.g., foods that were promoted by the intervention and also changed in maternal and child diets).

Methods

The intensive intervention provided interpersonal counseling, community mobilization, and mass media campaigns to promote breastfeeding and complementary feeding. …