Medicine and Health Sciences Commons^™

National Death Rates From Firearms Due To Legal Intervention For Native Americans, Hanrui Huang

OHSU-PSU School of Public Health Annual Conference

According to the CDC, deaths from legal intervention are defined as deaths caused by injuries inflicted by law enforcement officers. Although some studies have examined high rates of fatal legal intervention shootings among African Americans, rates for Native Americans have not been adequately examined, despite similar racial biases and stereotypes. This study aims to examine national data and examine the association of fatal legal intervention shootings and Native communities.

The available data provided on legal intervention (CDC) was studied to understand death rates for different races. The data was then analyzed to examine changes over time between 2008 and 2018. …

The Epidemiology Of Firearm-Related Injuries Presenting At The Two Level-1 Trauma Centers In Oregon From 2009-2019, Kamil Narayan, Kathleen F. Carlson, Susan Defrancesco

OHSU-PSU School of Public Health Annual Conference

Injury is an important clinical and public health problem worldwide. Firearm-related injury is an important source of trauma-related morbidity and increases the risk of death. The CDC reports that in 2017, 74.5% of homicides deaths and 50.6% of suicide deaths were caused by firearms. The purpose of our retrospective chart review is to describe the epidemiology of firearm-related injuries presenting in the emergency department of two level-1 trauma centers in Oregon over a 10-year period. The study involves victims of gunshot injuries of all ages who were treated in the OHSU and Legacy Emanuel Emergency Department during the calendar years …

Associations With Early Intervention Evaluation, Eligibility, And Services Engagement In A Multi-Site Sample, Mohadeseh Solgi, Katharine Zuckerman, Alicia Feryn

OHSU-PSU School of Public Health Annual Conference

TITLE: Associations with Early Intervention Evaluation, Eligibility, and Services Engagement in a multi-site sample

Background: Parental concerns are usually highly predictive of child developmental delays; however, the relationship of parent concerns with Part C Early Intervention (EI) service use is unclear.

Objective: The goals of this project were to test the associations of parent concern presence, age of child at time of parent concerns, number of concerns, type of parental concern, and recency of parental concerns, with EI evaluation, eligibility, and services engagement after referral.

Design/Methods: We collected survey data on parent concerns, EI service use data, and family demographics …

Structure, Function And Metabolism Of Hepatic And Adipose Tissue Lipid Droplets: Implications In Alcoholic Liver Disease, Sathish Kumar Natarajan, Karuna Rasineni, Murali Ganesan, Dan Feng, Benita L. Mcvicker, Mark A. Mcniven, Natalia A. Osna, Justin L. Mott, Carol A. Casey, Kusum K. Kharbanda

School of Veterinary and Biomedical Sciences: Faculty Publications

For more than 30 years, lipid droplets (LDs) were considered as an inert bag of lipid for storage of energy-rich fat molecules. Following a paradigm shift almost a decade ago, LDs are presently considered an active subcellular organelle especially designed for assembling, storing and subsequently supplying lipids for generating energy and membrane synthesis (and in the case of hepatocytes for VLDL secretion). LDs also play a central role in many other cellular functions such as viral assembly and protein degradation. Here, we have explored the structural and functional changes that occur in hepatic and adipose tissue LDs following chronic ethanol …

Important Commencement Information, April 7, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo from the Office of the Registrar to graduating students about options for commencement.

2020-04-07_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health departments …

Histidine-Triad Hydrolases Provide Resistance To Peptide-Nucleotide Antibiotics., Eldar Yagmurov, Darya Tsibulskaya, Alexey Livenskyi, Marina Serebryakova, Yury I Wolf, Sergei Borukhov, Konstantin Severinov, Svetlana Dubiley

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The Escherichia coli microcin C (McC) and related compounds are potent Trojan horse peptide-nucleotide antibiotics. The peptide part facilitates transport into sensitive cells. Inside the cell, the peptide part is degraded by nonspecific peptidases releasing an aspartamide-adenylate containing a phosphoramide bond. This nonhydrolyzable compound inhibits aspartyl-tRNA synthetase. In addition to the efficient export of McC outside the producing cells, special mechanisms have evolved to avoid self-toxicity caused by the degradation of the peptide part inside the producers. Here, we report that histidine-triad (HIT) hydrolases encoded in biosynthetic clusters of some McC homologs or by standalone genes confer resistance to McC-like …

Osteopathy And The Pandemic Of 1918, Robyn Oro

Notes from the Archives

No abstract provided.

2020-04-07 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Balance Of Adults With Chronic Ankle Instability Following A 6-Week Core Stability Program, Natalie Dickol

Theses and Dissertations

Ankle injuries are one of the most common injuries in the athletic population because of the anatomy of the ankle in conjunction with dynamic activity. During injury, mechanoreceptors are damaged, effecting neuromuscular control. Lack of neuromuscular control puts patients at risk for re-injury. Chronic ankle instability (CAI) has been defined as a condition associated with recurrent sprains and persistent symptoms, including feelings of "giving way," loss of function and limited movement and continuous ankle pain. Patients with CAI are commonly shown to have functional deficits in postural control, such as overcompensating on the uninvolved limb or unable to maintain proper …

A Mutation-Specific, Single-Arm, Phase 2 Study Of Dovitinib In Patients With Advanced Malignancies., Matthew H Taylor, Ajjai S Alva, Timothy Larson, Sebastian Szpakowski, Das Purkaystha, Alpesh Amin, Linda Karpiak, Sarina A Piha-Paul

Articles, Abstracts, and Reports

BACKGROUND: Receptor tyrosine kinases (RTKs) play key roles in tumorigenesis. The multi-RTK inhibitor dovitinib has demonstrated promising antitumor activity in multiple cancers.

PATIENTS AND METHODS: In this phase 2, open-label, single-arm study, patients with advanced malignancies with RTK-pathway genetic aberrations whose disease progressed on/following standard treatment received dovitinib (500 mg/day; 5-days-on/2-days-off). The primary endpoint was clinical benefit rate (CBR; complete response, partial response [PR], or stable disease [SD] for ≥ 16 weeks).

RESULTS: Of 80 patients enrolled, common tumors included gastrointestinal stromal tumors (GIST; 20.0%), colorectal cancer (CRC; 18.8%), and ovarian cancer (10.0%). Patients were heavily pretreated (median prior lines …

Lived Experiences With Inauthenticity Of The Physician Assistant Program Admission Essay: A Phenomenological Study, Pollyanna Kabara

CUP Ed.D. Dissertations

Inauthenticity occurs in the physician assistant program admission process when students plagiarize content of the admission essay. This qualitative research study focused on the experiences of physician assistant admission committee members with the admission process, including the experiences of physician assistant admission committee members with the authenticity of the admission process. The experience with the components of the admission process were discussed through eight interviews with physician assistant admission committee members from accredited physician assistant programs in the United States. Phenomenology was the research method used to evaluate the experience the admission committee members have had with the components of …

Increasing Knowledge And Self-Efficacy In Nurses Orienting To Cardiovascular Surgery Using A New Periop 202 Program, David Reinhart

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

The operating room theater can be intimidating for new nurses, thus leading to a shortage of nurses who are comfortable working in this environment. Evidence supports that 50% of perioperative nurses in 2017 were between the age of 50 and 59. Additionally, no formal didactic courses are being offered in undergraduate programs and the challenging environment related directly to the future shortage of perioperative nurses. This negatively impacts the number of trained perioperative cardiovascular nurses. The project proposed a new didactic educational Perioperative (Periop) 202 program that aimed to increase nurses’ self-efficacy to function on the cardiovascular operating room (CVOR) …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Kinesiology Student Awarded Grant by I'm An Athlete to Assist with Research

2020-04-07 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Anastasiya Nestsiarovich, Praveen Kumar, Hannah Groves, Danielle Rivera, Estefania Montanez, Tudor I. Opera, Andrew S. Rowland, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

Today we celebrate World Health Day: JAMA suggests ways to support healthcare workers in the crisis. NM Emergency orders extended. Some NM prisoners freed. Pueblos threatened by outbreaks. CDC to provide $186M in state funding for surveillance programs. Colleges hit hard financially. Nine states refuse to issue stay-at-home order. Wuhan cautiously ends its 76-day lockdown. Lack of cough and fever for children creates special challenges. Fauci JAMA interview tomorrow. WHO guidelines and megatrial of 4 therapies. Numerous CDC guidelines. 23 clinical trials registered today. One negative result on hydroxychloroquine efficacy. In vitro screens suggest promising FDA drugs for …

First-In-Human Studies Of Mw01-6-189wh, A Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, And Pharmacodynamic Studies In Healthy Adult Volunteers, Linda J. Van Eldik, Lumy Sawaki, Karen Bowen, Daniel T. Laskowitz, Robert J. Noveck, Byron Hauser, Lynn Jordan, Tracy G. Spears, Huali Wu, Kevin Watt, Shruti Raja, Saktimayee M. Roy, D. Martin Watterson, Jeffrey T. Guptill

Sanders-Brown Center on Aging Faculty Publications

MW01-6-189WH (MW189) is a novel central nervous system-penetrant small-molecule drug candidate that selectively attenuates stressor-induced proinflammatory cytokine overproduction and is efficacious in intracerebral hemorrhage and traumatic brain injury animal models. We report first-in-human, randomized, double-blind, placebo-controlled phase 1 studies to evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending intravenous doses of MW189 in healthy adult volunteers. MW189 was safe and well tolerated in single and multiple doses up to 0.25 mg/kg, with no clinically significant concerns. The most common drug-related treatment-emergent adverse event was infusion-site reactions, likely related to drug solution acidity. No clinically concerning changes …

The Relationship Between The Prevalence Of Cardiovascular Disease And Health Risk Appraisals In College-Age Students, Brandi Curtis

Theses and Dissertations

The purpose of this study is to investigate the prevalence of cardiovascular disease risk factors in college-age students as compared to their health risk appraisal score for cardiovascular disease. Two-hundred fifty-seven females and two-hundred eight males from a moderately-sized, midwestern university participated in the study with the subjects having a mean age of 21.06 ±2.13 yr. and 21.57 ±2.34 yr., a BMI of 23.89 ±4.64 and 25.73± 4.03, and a body fat of 27.88 ±8.91% and 17.86± 8.49%, respectively. All testing was completed during a single session. Height and weight were obtained to calculate body mass index (BMI). Physical fitness …

What Did We Learn About Vads In 2019?, Maya Guglin

The VAD Journal

This is our 6th annual literature review on mechanical circulatory support (MCS) devices.

Our previous reports for 2014, 2015, 2016, 2017, 2018 were published as open access articles and were well received by the readers. In this paper, we summarize the most interesting and important, from our standpoint, publications from 2019. As we have done for the past two years, a section on extracorporeal membrane oxygenation (ECMO) is included and primarily addresses new developments in veno-arterial ECMO use.

Kinematic And Acoustic Adaptation To A Bite Block During Syllable Production, Allison Marie Barney

Theses and Dissertations

The purpose of the current study was to gain a better understanding of speech adaptation by examining kinematic and acoustic adaptation to bite block perturbation over time. Fifteen native American English speakers (7 female, 8 male) with no history of speech, language, or hearing deficits participated in the study. Custom bite blocks were created for speakers which created a 10mm interincisal gap when inserted. Speakers produced five repetitions of the sentence, I say ahraw /ərɑ/ (as part of a larger set) prior to bite block insertion, immediately following bite block insertion, 2-mintues post insertion, 4-minutes post insertion, 6-minutes post insertion, …

School Of Nursing News, Georgia Southern University

Nursing: News & Publications (2013-2023)

• School of Nursing Ranked one of the Top Schools

Acetylation Of Histone H3k27 Signals The Transcriptional Elongation For Estrogen Receptor Alpha, Yujing Gao, Lijia Chen, Yali Han, Fangrui Wu, Wen-Si Yang, Zheng Zhang, Tong Huo, Yingmin Zhu, Chengtai Yu, Hong Kim, Mark Lee, Zhen Tang, Kevin Phillips, Bin He, Sung Yun Jung, Yongcheng Song, Bokai Zhu, Rui-Ming Xu, Qin Feng

Faculty, Staff and Students Publications

As approximately 70% of human breast tumors are estrogen receptor α (ERα)-positive, estrogen and ERα play essential roles in breast cancer development. By interrupting the ERα signaling pathway, endocrine therapy has been proven to be an effective therapeutic strategy. In this study, we identified a mechanism by which Transcription Start Site (TSS)-associated histone H3K27 acetylation signals the Super Elongation Complex (SEC) to regulate transcriptional elongation of the ESR1 (ERα) gene. SEC interacts with H3K27ac on ESR1 TSS through its scaffold protein AFF4. Depletion of AFF4 by siRNA or CRISPR/Cas9 dramatically reduces expression of ESR1 and its target genes, consequently inhibiting …

Integrating Mouse And Human Genetic Data To Move Beyond Gwas And Identify Causal Genes In Cholesterol Metabolism, Zhonggang Li, James A Votava, Gregory J M Zajac, Jenny N Nguyen, Fernanda B Leyva Jaimes, Sophia M Ly, Jacqueline A Brinkman, Marco De Giorgi, Sushma Kaul, Cara L Green, Samantha L St Clair, Sabrina L Belisle, Julia M Rios, David W Nelson, Mary G Sorci-Thomas, William R Lagor, Dudley W Lamming, Chi-Liang Eric Yen, Brian W Parks

Faculty, Staff and Students Publications

Identifying the causal gene(s) that connects genetic variation to a phenotype is a challenging problem in genome-wide association studies (GWASs). Here, we develop a systematic approach that integrates mouse liver co-expression networks with human lipid GWAS data to identify regulators of cholesterol and lipid metabolism. Through our approach, we identified 48 genes showing replication in mice and associated with plasma lipid traits in humans and six genes on the X chromosome. Among these 54 genes, 25 have no previously identified role in lipid metabolism. Based on functional studies and integration with additional human lipid GWAS datasets, we pinpoint Sestrin1 as …

Knitting Service-Learning And Professional Training: Advocating For Dental Care For People With Intellectual Disabilities, Raj Gandhi

The International Undergraduate Journal For Service-Learning, Leadership, and Social Change

No abstract provided.

The Relationship Between Working Memory, Procedural Learning, And Declarative Memory In Children With Specific Language Impairment, Allison Grace Herring

LSU Master's Theses

Background: Children with specific language impairment (SLI) have recently been suggested to have subclinical deficits in executive function skills. The current study seeks to better understand these deficits by exploring the role of nonverbal working memory in word learning and statistical learning in this population. Method: Participants included typically developing children along with children with SLI ranging from ages 8-12 years old. Word learning was assessed using a fast-mapping task, statistical learning was measured using a word-segmentation task, and nonverbal working memory was measured using an N-back task. Results: A significant difference was found between children’s segmentation accuracy scores. …

Old Habits—A Semester At Home In 2020, Hannah Tienvieri

Reflections, Poetry, Photos, and other Writings

This is a poem I wrote after the student body was sent home for the remainder of the spring semester. This piece is an expression of the isolation and unique feeling of regression that came in the early days of the pandemic, particularly caused by being confined to my childhood bedroom.

Correlation Between Cognition And Balance Among Middle-Aged And Older Adults Observed Through A Tai Chi Intervention Program, Tao Xiao, Lin Yang, Lee Smith, Paul D. Loprinzi, Nicola Veronese, Jie Yao, Zonghao Zhang, Jane Jie Yu

Faculty and Student Publications

© Copyright © 2020 Xiao, Yang, Smith, Loprinzi, Veronese, Yao, Zhang and Yu. Background: Age-associated decline in cognition and balance may cause severe ability loss for daily living activities among middle-aged and older adults. The relationship between cognition and balance in this aging population remains to be explored. Objective: The present study Is exploratory in nature and aimed to examine the relationship between balance (both static and dynamic components) and global cognitive function among middle-aged and older adults through Tai Chi (TC) practice as a research avenue. Methods: A short-term (12 weeks) intervention of TC was conducted among middle-aged and …

2020 April 6 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Ada News - 04/06/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Democratic Governors Are Quicker In Responding To The Coronavirus Than Republicans, Luke Fowler, Jaclyn Kettler, Stephanie Witt

Public Policy and Administration Faculty Publications and Presentations

While the coronavirus pandemic is a national and international concern, state and local officials find themselves on the front lines of the public health battle.

Governors, in particular, have been in the spotlight in recent weeks. New York’s Andrew Cuomo has been praised by news outlets for his leadership at the epicenter of the U.S. outbreak, while others have been criticized for slow responses.

A clear partisan gap has emerged in how quickly governors have declared emergencies and issue stay-at-home orders. Democratic governors have issued orders three to four days sooner than Republican governors, on average.

Covid-19: Hospital And Intensive Care Unit (Icu) Bed Capacity In The Mountain West, Ember Smith, Kaylie Pattni, Caitlin Saladino, William E. Brown

Health

Utilizing the Harvard Global Health Institute’s (HGHI) COVID-19 projections, this fact sheet examines the potential hospital and ICU bed shortages in the Mountain West region: Arizona, Colorado, New Mexico, Nevada, and Utah.