Medicine and Health Sciences Commons^™

2020-04-27 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Week Of April 27, 2020, New York Medical College

InTouch

• NYMC Observes Yom Hashoah Virtually
• NYMC Experts Leading the Way in Coronavirus Updates

Development And Characterization Of Selective Cb2r Inverse Agonists As A Novel Anti-Inflammatory Therapy For Neuroinflammation – Mechanisms Of Action In Murine And Human Microglia Models Provide Valuable Insights Into Their Therapeutic Potential, Sahar Saleh Alghamdi

Theses and Dissertations (ETD)

Introduction: Recently, research has revealed the presence of cannabinoid receptor 2 (CB2R) in the central nervous system (CNS); since then, the receptor has emerged as a promising therapeutic target for treating multiple neurodegenerative diseases (NDD) such as Alzheimer’s (AD), Parkinson’s (PD), Human Immunodeficiency Virus (HIV) and Multiple Sclerosis (MS). The restricted and upregulated expression of CB2R in activated microglia and lack of psychotropic activity make this receptor an attractive target for discovering novel therapy to treat neuroinflammatory diseases for which there is currently no curative treatment. Methodology: A library of compounds were synthesized and evaluated in ACTOne and TANGO-bla functional …

Relation Between Linguistic Awareness Skills And Spelling In Adults: A Comparison Among Scoring Procedures, Victoria Henbest

Victoria S. Henbest Publications

Spelling is a skill that relies on an individual's linguistic awareness, the ability to overtly manipulate language. The ability to accurately spell is important for academic and career success into adulthood. The spelling skills of adults have received some attention in the literature, but there is limited information regarding which approach for analyzing adults' spelling is optimal for guiding instruction or intervention for those who struggle. Thus, we aimed to examine the concurrent validity of four different scoring methods for measuring adults' spellings (a dichotomous scoring method and three continuous methods) and to determine whether adults' linguistic awareness skills differentially …

Challenges Of Pediatric Disease In Adulthood, Dennis J. Baumgardner, Brian Chicoine

Journal of Patient-Centered Research and Reviews

Some chronic diseases — such as the rare bone disease X-linked hypophosphatemia, the impetus for a study reported within Volume 7, Issue 2 of the Journal of Patient-Centered Research and Reviews — are diagnosed in childhood but become more symptomatic in adulthood. In this editorial, the challenges, pitfalls, and opportunities regarding the care of adults with childhood-onset chronic diseases are examined using Down syndrome, cystic fibrosis, congenital heart disease, and Hirschsprung disease as examples.

What Outcomes Matter To Patients After Joint Or Spine Surgery?, Robin R. Whitebird, Leif I. Solberg, Christine K. Norton, Jeanette Y. Ziegenfuss, Stephen E. Asche, Elizabeth S. Grossman

Journal of Patient-Centered Research and Reviews

Purpose: Patient-reported outcome measures (PROMs) are increasingly used in clinical care, but there have been few studies of what patients identify as the most important outcomes.

Methods: Semi-structured interviews were conducted with 65 patients undergoing hip or knee replacement, spinal discectomy/laminotomy, or a spinal fusion. Interviews focused on outcomes patients identified as important, perceived usefulness of standardized PROMs measures, and contextual situations important to their care. Data were analyzed using a directed content analysis approach.

Results: Patients identified desired outcomes that were unique and important to them. Their preferred outcomes focused in the areas of freedom from pain, getting back …

Giving Credence To The Experience Of X-Linked Hypophosphatemia In Adulthood: An Interprofessional Mixed-Methods Study, Melissa Hughes, Carolyn Macica, Catherine Meriano, Maya Doyle

Journal of Patient-Centered Research and Reviews

Purpose: X-linked hypophosphatemia (XLH) is a rare X-linked dominant metabolic bone disease, often diagnosed in childhood but causing increasing physical debilitation and pain in adulthood. Physical comorbidities of XLH in adulthood include pervasive and early-onset degenerative arthritis, mineralizing enthesophytes and osteophytes, osteomalacia and pseudofracture, dental abscesses, and hearing loss.

Methods: This mixed-methods analysis included physical findings, diagnostic imaging, occupational and physical therapy assessments, and semi-structured interviews by social work to understand the functional outcomes and lived experience of XLH in adulthood, through connections between qualitative data obtained by social work and occupational therapy with the quantitative findings from other disciplines. …

Caries Prevalence And Severity In Immature Permanent First Molar Teeth In Sanliurfa City, Turkey, Ahmet Aras, Mehmet Sinan Dogan

Journal of Dentistry Indonesia

The prevalence of dental caries, a major public health problem in high-income countries, is gradually increasing in many low- and middle-income countries. The aim of this study is to evaluate the prevalence and severity of caries in the immature permanent first molars (PFMs) of children aged 7–9 years. Methods: This work is a retrospective analysis of caries in immature PFMs as observed from the panoramic radiographs of patients aged 7–9 years who presented to the pediatric clinic. The mean number of decayed, missing, or filled teeth (DMFT) and caries severity of immature PFMs were assessed. Results: A total of 3,112 …

Demographic And Clinical Profile Of Gingival Oral Lichen Planus In A Group Of Thai Individuals, Pissacha Daroonpan, Ruchadaporn Kaomongkolgit, Weeraya Tantanapornkul, Jadesada Palasuk

Journal of Dentistry Indonesia

Objective: This study aimed to determine the clinical profile of the gingival lesions of oral lichen planus (OLP) in a group of Thai patients. Methods: The dental records of 67 patients were reviewed. Results: In this study, 51 (76.1%) women and 16 (23.9%) men with a female-to-male ratio of 3.2:1 were included. The average age of patients with OLP was 56.0 ± 12.5 years (ranged = 20–81 years). Furthermore, 52 (77.6%) patients had a history of systemic diseases, and hypertension was predominant. All the patients presented with symptomatic OLP. Multiple OLP lesions were observed in 56 (83.6%) …

Evaluation Of The Relation Between Impacted Mandibular Third Molar Classification And Inferior Alveolar Canal, Sinan Yasin Ertem, Halil Anlar

Journal of Dentistry Indonesia

Objective: The development, eruption, and proximity of mandibular third molars with the inferior alveolar canal are highly variable. The classification of mandibular third molars and their relationship with the inferior alveolar canal were discussed. Methods: A total of 1,024 orthopantomograms (OPGs) from 422 male patients and 602 female patients were examined. The position of the mandibular third molars and their proximity to the inferior alveolar canal were evaluated. Results: Mandibular third molars were observed in 652 (63.67%) of the 1,024 OPGs. According to the Winter’s classification, the most common position of third molars was the vertical position …

Health-Related Anxiety In The Management Of Oral Soreness In An Hivseropositive Patient, Masita Mandasari, Zulvia Oktanida Syarif, Febrina Rahmayanti

Journal of Dentistry Indonesia

The number of people living with HIV (PLHIV) has been increasing since the first known case in the early 1980s. However, PLHIV can also experience comorbidities, such as health anxiety. In the oral cavity, anxiety is often associated with the etiology of parafunctional habits. Anxiety can be measured using self-administered instruments, such as the Hospital Anxiety and Depression Scale (HADS) and Short-Health Anxiety Inventory (SHAI), which is specifically used in the medical setting. Objectives: We are describing a case of HIV positive patient with health anxiety who presented to the oral medicine clinic in our hospital with a complaint of …

Differential Diagnosis And Histopathological Analysis Of Localized Gingival Overgrowths: Study Of 218 Cases From Northeast Thailand, Lordjie Marr Morilla, Ajiravudh Subarnbhesaj, Poramaporn Klanrit

Journal of Dentistry Indonesia

Localized gingival overgrowths (LGOs) are relatively common clinical findings. These lesions can be associated with chronic irritation, infections, or they can represent benign or malignant tumors that can either be primary or metastatic. The etiology of these lesions is multifactorial, but the most prevalent cause is reactive hyperplasia and inflammation induced by dental plaque. Objective: This study presents the prevalence of LGOs in Northeast Thailand and identifies the most common LGOs in the region. Methods: A series of 218 LGO cases was studied. Results: Pyogenic granuloma (PG), gingival squamous cell carcinoma (GSCC), and peripheral ossifying fibroma (POF) were the three …

Effect Of Acid Etching And Er:Yag Laser Enamel Conditioning On The Microleakage Of Glass Carbomer Fissure Sealants, Neslihan Ozveren, Yesim Sesen Uslu, Nazmiye Donmez

Journal of Dentistry Indonesia

Objective: This study aimed to evaluate the effects of Er:YAG laser used alone or in combination with acid etching as surface conditioners on the microleakage of a glass carbomer fissure sealant for permanent molar teeth.

Methods: Forty sound human permanent molar teeth were randomly divided into four experimental groups based on enamel etching methods: group I, no surface conditioning; group II, 37% phosphoric acid etching; group III, Er:YAG laser etching; and group IV, sequential laser etching and acid etching. After surface conditioning procedures were conducted, the teeth were sealed with a glass carbomer seal. The teeth were subjected …

Evaluation Of Clinical Single Dental Implants Made Between 2013 And 2017, Zozan Erdoğmuş

Journal of Dentistry Indonesia

Objective: This retrospective study aimed to determine the profile of patients who underwent single tooth implants between 2013 and 1017 and to evaluate long-term follow-up and success. Methods: The results of 79 patients who underwent single dental intra-bone dental implantation in Diyarbakır Oral and Dental Health Hospital between 2013 and 2017 were evaluated separately in terms of gender, age, implanted area and number, systemic diseases affecting implant health, and missing implants. Results: In this study, single tooth implants were evaluated in 79 patients with a mean age of 39.55 years in men and 30.44 years in women. …

Oral Health And Related Behavior Of Children Aged 9–12 With Attention Deficit Hyperactivity Disorder In Tron District, Thailand, Duangruethai Khobkham, Kanyarat Korwanich, Narumanas Korwanich

Journal of Dentistry Indonesia

Attention deficit hyperactivity disorder (ADHD) is a common biobehavioral childhood disorder that leads to significant behavioral problems that affect everyday life. Objective: This study aimed to compare oral health and oral health behaviors among children with and without ADHD. Methods: The study included 105 children aged 9–12 years with ADHD and 105 age-, gender-, and family income-matched children without ADHD. Clinical data as caries, periodontal health, and traumatic dental injuries were recorded by calibrated examiners. All parents of the children completed questionnaires about the oral health behaviors of their children by a single interview. Data were compared using Chi-square test, …

Management Of Atypical Symmetrical Ankylosis Of Maxillary Deciduous First Molars With Permanent Successors: A Single Case Report, Kemal Gulduren, Aylin İslam

Journal of Dentistry Indonesia

Dentoalveolar ankylosis is the union between the tooth root and the dentoalveolar bone. Clinically, the affected tooth is unsuccessful to erupt, exhibits an infraocclusal position within the dentoalveolar arch, elicits a metallic sound on percussion, and has reduced or absent mobility. Objective: This single case report illustrates the management of idiopathically ankylosed maxillary deciduous first molars. Case report: The patient was a 6-year-old female with maxillary deciduous first molars in infraocclusal position due to idiopathic ankylosis. The ankylosed deciduous teeth were monitored regularly. After a 27-month follow-up, the infraocclusion became severe. No vertical deficiencies in other alveolar regions were detected. …

Erupted Compound Odontoma Associated With Missing Tooth: A Rare Case Report, Weeraya Tantanapornkul, Ruchadaporn Kaomongkolgit, Sirilawan Tohnak, Lalitkorn Promma, Soranan Chantarangsu

Journal of Dentistry Indonesia

Odontomas are one of the most frequently found odontogenic tumors that consist of dental tissues. Odontomas have been classified into two types: compound and complex odontomas. They are usually discovered on routine radiographic examination. In rare cases, the odontoma erupt into the oral cavity, called an erupted odontoma. The first case was published in 1980, and since then, there have been not more than 50 cases being reported in the literature. Most of the reported cases are erupted complex odontoma. This case report represents a rare case of an erupted compound odontoma in a young patient who came with the …

Myocardial Work Index: A Novel Method For Assessment Of Myocardial Function In South Asian Recreational Athletes, Shantanu Sengupta, Renuka Jain, Nitin Burkule, Susan Olet, Bijoy K. Khandheria

Journal of Patient-Centered Research and Reviews

Purpose: We used a novel noninvasive method based on speckle-tracking echocardiography to evaluate myocardial performance in South Asian recreational athletes who completed a half marathon.

Methods: Transthoracic echocardiography was performed on 24 recreational athletes 48 hours before they took part in a half marathon (premarathon), within 2 hours of half marathon completion (postmarathon), and 72 hours after completion. Clinical, laboratory, and echocardiographic variables were collected. Speckle-tracking echocardiography was performed in all subjects to characterize myocardial mechanics.

Results: Mean age of participants was 41.8 ± 7.4 years, and 23 (95.8%) were male. No subject had a prior history of coronary artery …

Dancing During Labor: Social Media Trend Or Future Practice?, Caroline P. Toberna, Drew Horter, Kayla Heslin, Marie M. Forgie, Emily Malloy, Jessica J. F. Kram

Journal of Patient-Centered Research and Reviews

Over the past 30 years, medical interventions in pregnancy and childbirth have increased. Some pregnant women seek less invasive and nonpharmacological options to manage discomforts during labor. While exercise during pregnancy is recommended, less is known about exercise, specifically dancing, during labor. While anecdotal evidence is supportive, little is known about the implications of exercise and dance during the first stage of labor for pain reduction and labor progression. Some movements common in dance, such as expanding hip circles that loosen and relax muscles of the pelvic floor, may be beneficial to women during labor. Available evidence suggests that dancing …

Letter To The Editor: Pediatric Injuries In Kids Cafés And Risk Factors For Significant Injuries: A 6-Year Cross-Sectional Study Using A Multicenter Injury Registry In Korea, Akbar Shoukat Ali, Raheel Allana, Rahim Jandani

Department of Medicine

No abstract provided.

Fear Not...No Falls, Jennifer A. Rabenold Msn, Rn, Cdn

Patient Care Services / Nursing

No abstract provided.

Sars-Cov-2 Infection In A Patient On Chronic Hydroxychloroquine Therapy: Implications For Prophylaxis, Khalid M. Dousa, Sharad S. Malavade, Jennifer Furin, Barbara Gripshover, Marjorie Hatszegi, Leila Hojat, Elie Saade, Robert A. Salata

Faculty Scholarship

People exposed to COVID-19 have a risk of developing disease, and health care workers are at risk at a time when they are badly needed during a health care crisis. Hydroxychloroquine and chloroquine have been used as treatment and are being considered as prophylaxis. Our patient developed COVID-19 while on hydroxychloroquine and although more work is needed, this calls into question the role of these medications as preventive therapy.

Infectious Diseases Society Of America Guidelines On The Treatment And Management Of Patients With Covid-19, Amy Hirsch, Yngve Falck-Ytter

Faculty Scholarship

Background: There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature. Objective: Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. Methods: IDSA formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. Process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and …

Exploratory Analysis Of The Relationship Between Tnf-Α And Sbp In The Baseline Cohort Of The Dietary Approaches To Stop Hypertension (Dash)-Sodium Trial, Khalid Farhan

Annual SHSP Student Research and Scholarship Day

No abstract provided.

The Weekend Effect Among High Ed Utilizers, Wilson Tan, Adam Block

Annual SHSP Student Research and Scholarship Day

No abstract provided.

Medical School Watercooler Newsletter - April 26, 2020, Lindsey Lyle

Watercooler Newsletter

This is the April 26, 2020 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Daniel to receive alumni award from UAB Public Health

Phung, physician-scientist, joins pathology faculty at USA College of Medicine

Feelings are neither good nor bad – they just are

2020-04-26_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

2020-04-26_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.

2020-04-26_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data is updated on an ongoing basis.

MDHHS has established a regional hub strategy to assist in reducing the spread of COVID-19 within nursing facilities. COVID-19 Regional Hubs have established units dedicated to treating COVID-19-affected individuals and have established appropriate staffing levels and protocols to support this level of care.
These case counts reflect current cases of COVID-19 among facility residents reported …

2020-04-26_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health departments …