Medicine and Health Sciences Commons^™

Youth Tackle Football: A Parent's Decision, Steven Smallshaw

Undergraduate Theses and Capstone Projects

In this paper I will look at the statistics and likelihood of brain damage occurring in children who participate in full contact football, using a 2017 study done by Boston University’s Chronic Traumatic Encephalopathy Center, where former football players were tested for the effects of sustained trauma they first received from playing tackle football at a young age. This paper seeks to explain why participation in youth tackle football is still so high despite studies from Boston University and others like it. This paper incorporates interviews from coaches and directors of youth football elaborating on their opinions of young children’s …

The Need For Change In Emergency Medical Approach When Caring For Individuals With Autism, Hannah Watkins

Undergraduate Theses and Capstone Projects

This paper highlights the need for policy changes and additional training related to caring for individuals with autism in emergency situations. Individuals with autism spectrum disorder are at risk of receiving inadequate care due to the challenges that come with such a complex diagnosis. Depending on the severity of autism for each individual, behavioral outbursts and aggression can often occur due to the overwhelming amount of stimulation in the emergency department environment. While medical professionals have the potential to be a great help during times of crisis, there is often very little training given to providers in regard to delivering …

Results Of The Adhere Upper Airway Stimulation Registry And Predictors Of Therapy Efficacy., Erica Thaler, Richard Schwab, Joachim Maurer, Ryan Soose, Christopher Larsen, Suzanne Stevens, Damien Stevens, Maurits Boon, Colin Huntley, Karl Doghramji, Tina Waters, Alan Kominsky, Armin Steffen, Eric Kezirian, Benedikt Hofauer, Ulrich Sommer, Kirk Withrow, Kingman Strohl, Clemens Heiser

Department of Psychiatry and Human Behavior Faculty Papers

OBJECTIVE/HYPOTHESIS: The ADHERE Registry is a multicenter prospective observational study following outcomes of upper airway stimulation (UAS) therapy in patients who have failed continuous positive airway pressure therapy for obstructive sleep apnea (OSA). The aim of this registry and purpose of this article were to examine the outcomes of patients receiving UAS for treatment of OSA.

STUDY DESIGN: Cohort Study.

METHODS: Demographic and sleep study data collection occurred at baseline, implantation visit, post-titration (6 months), and final visit (12 months). Patient and physician reported outcomes were also collected. Post hoc univariate and multivariate analysis was used to identify predictors of …

Occupational Therapy Student Preparedness For Clinical Fieldwork, Jean A. Mccaffery

All Theses And Dissertations

Topic, Problem and Purpose: Experiential learning and occupational therapy student preparedness. Occupational therapy education programs must prepare occupational therapy students for practice. Traditional observational Level I Fieldwork presents challenges to achieve student-learning objectives and often places the burden of supervision on practicing therapist. The purpose of this study was to explore occupational therapy students’ perceptions of preparedness for Level II Fieldwork following participation in a skill-based experiential learning opportunity as an alternative to traditional observational Level I Fieldwork.

Research Question and Sub-Questions: What is the graduate occupational therapy student’s perception of preparedness for intensive Level II Fieldwork following a skill-based, …

Equine Massage Following Intense Work: Effects On Plasma Creatine Kinase, Brittany Pilat

Undergraduate Honors Thesis Projects

Horses are elite athletes, and many of them receive specialized care to keep them operating at their highest potential. Alternative modalities of healing- such as equine massage- have begun to grow in the equine world due to many perceived benefits. Equine massage is thought to decrease inflammation and reduce muscle tension and soreness. The aim of this study was to observe the effect of equine massage on creatine kinase (CK) levels in the blood following intense work. A total of 12 horses were randomly assigned to either the control group (n=6) or the test group (n=6). All horses were exercised …

Dietary Fat And Sugar Differentially Affect Β-Adrenergic Stimulation Of Cardiac Erk And Akt Pathways In C57bl/6 Male Mice Subjected To High-Calorie Feeding, Sadia Ashraf, Gizem Yilmaz, Xu Chen, Romain Harmancey

Faculty, Staff and Student Publications

BACKGROUND: High dietary fat and sugar promote cardiac hypertrophy independently from an increase in blood pressure. The respective contribution that each macronutrient exerts on cardiac growth signaling pathways remains unclear.

OBJECTIVE: The goal of this study was to investigate the mechanisms by which high amounts of dietary fat and sugar affect cardiac growth regulatory pathways.

METHODS: Male C57BL/6 mice (9 wk old; n = 20/group) were fed a standard rodent diet (STD; kcal% protein-fat-carbohydrate, 29-17-54), a high-fat diet (HFD; 20-60-20), a high-fat and high-sugar Western diet (WD; 20-45-35), a high-sugar diet with mixed carbohydrates (HCD; 20-10-70), or a high-sucrose diet …

Unique Case Of Anca-Negative Pauci-Immune Necrotizing Glomerulonephritis With Diffuse Alveolar Hemorrhage, Potentially Associated With Midostaurin, Jonathan D Pankow, Guillaume Richard-Carpentier, Naval G Daver, William F Glass, Jaya Kala

Faculty, Staff and Student Publications

We present a 61-year-old male with FLT3-mutated acute myeloid leukemia treated with midostaurin who developed acute kidney injury requiring hemodialysis and pulmonary renal syndrome. Antibodies to proteinase-3, myeloperoxidase, and glomerular basement membrane were negative. Renal biopsy confirmed acute pauci-immune focal necrotizing glomerulonephritis (GN) with fibrin crescents indicating rapidly progressing glomerulonephritis. He improved with pulse methylprednisolone, intravenous cyclophosphamide, and plasma exchange with resolution of hemoptysis. This case highlights the importance of prompt renal biopsy to guide early initiation of life-saving therapies. To our knowledge, this is the first reported case of ANCA-negative pauci-immune necrotizing GN likely secondary to midostaurin.

Draft Genome Sequences Of Two Extensively Drug-Resistant Strains Of Acinetobacter Baumannii Isolated From Clinical Samples In Pakistan, Sara Lomonaco, Matthew A. Crawford, Christine Lascols, Debra J. Fisher, Kevin Anderson, David R. Hodge, Segaran P. Pillai, Stephen A. Morse, Erum Khan, Molly A. Hughes, Marc W. Allard, Shashi K. Sharma

Department of Pathology and Laboratory Medicine

Infections in immunocompromised patients that are caused by extensively drug-resistant (XDR) Acinetobacter baumannii strains have been increasingly reported worldwide. In particular, carbapenem-resistant A. baumannii strains are a prominent cause of health care-associated infections. Here, we report draft genome assemblies for two clinical XDR A. baumannii isolates obtained from hospitalized patients in Pakistan.

Collective Imagination, Haley Lynch

Psychology

Life is filled with experiences that contribute to who we are, who we will become, and the social connections we make. We are constantly reflecting on past experiences, be it alone or with others, as well as thinking about what is to come and where we see ourselves in the future. Social and cognitive psychology research has focused on the processes behind autobiographical memory and episodic simulation. The link between collective memory and episodic simulation is the focus of the present study. The specific aim is to explore the potential link between reflecting on past experiences and imagining the future …

Neurological Manifestations Of Covid-19, Dureshahwar Kanwar, Abdul Mannan Baig, Mohammad Wasay

Section of Neurology

Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has turned out to be a formidable pandemic. Upcoming evidence from confirmed cases of COVID-19 suggests an anticipated incursion of patients with neurological manifestations in the weeks to come. An expression of the angiotensin-converting enzyme 2 (ACE 2), the cellular receptor for SARS-CoV-2 over the glial cells and neurons have made the brain a potential target. Neurotoxicity may occur as a result of direct, indirect and post-infectious complications. Attention to neurological deficits in COVID-19 is fundamental to ensure appropriate, timely, beneficial management of the affected patients. Most …

New Trends In Radiology Education, Time To Adapt Locally, Faheem Ullah Khan, Noman Khan, Muhammad Arif Saeed

Department of Radiology

No abstract provided.

Rational And Practical Use Of Imaging In Covid-19 Pneumonia, Saba Sohail

Department of Radiology

The severe form of the COVID-19 pandemic caused by the SARS-CoV-2 virus, has largely manifested as a predominant respiratory illness causing severe pneumonia characterized by bilateral, subpleural ground glass haze, progressing to consolidation, and fibrosis on imaging. There is some discrepancy between the governmental guidelines, professional Societies and Radiology and Respiratory Medicine specialists with divided opinions between the use of the chest X-rays and CT scan, and whether the use be screening or diagnostic. So far, the most balanced recommendations have been proposed by the Fleischner Society, which are endorsed by the Radiological Society of Pakistan as well. This writeup …

A Comparison Of Vertical Ground Reaction Forces In Single-Leg Jump Take-Offs And Double-Leg Jump Take-Offs In Indoor Collegiate Volleyball Players, Margaret Elisabeth Latchford, Maggie Mcdermott, Austin Deshner, Moroni De Moors, Will W. Peveler

Masters Theses

The purpose of this study was to determine if differences in vertical ground reaction forces (vGRFs) exist between single-leg take-off approaches (SL) and double-leg take-off approaches (DL) and if sex or positional differences existed in vGRFs in SL- or DL-style approaches. It was hypothesized that DL jumps would generate greater vGRFs, males would generate greater vGRFs in both styles, and middle blockers would have higher SL vGRFs while pin hitters would have higher DL vGRFs. Nine collegiate volleyball players (4 female; 5 male) (age: 20.44 ± 1.42 years; height: 186.02 ± 6.44 cm; body mass: 78.21 ± 10.63kg; body fat: …

Determining The Prevalence And Impact Of Bullying And Cyberbullying As A Contributing Factor In Patients Who Have Been Admitted Into An Inpatients Facility., Kelley Kardys, Rachel Pfafman, Connie Kerrigan, Lauren Reining, Michelle Drouin, Jessica Pater

Health Services and Informatics Research

Presented in APNA 33rd Annual Conference, October 2-5, 2019, New Orleans, Louisiana: Mini Concurrent Session Abstracts.

Parkview Project: Cyberbullying

Clinical Features, Diagnosis And Management Of Covid-19 Patients In The Outdoor Setting, Bushra Jamil

Department of Medicine

In a brief span of a few months, coronavirus disease (COVID-19) pandemic has brought a major paradigm shift in operation of clinical services around the world. Infection may be mild, moderate or severe; many remain asymptomatic. High burden of non-communicable and communicable diseases theoretically puts Pakistani population at increased risk of severe COVID-19 infection. Considering the universal risk of infection, the outpatient services in Pakistan need to be redesigned. Starting with risk assessment of the facility and provision of a dedicated telephone connection, structure and workflow need to be redesigned in order to minimise risk of exposure to healthcare professionals, …

How Positive And Negative Affect Relate To Postoperative Pain In Children Undergoing Surgery, Stephanie Munduruca, Ryan Johnson

Student Scholar Symposium Abstracts and Posters

Positive affect has been shown to be associated with lower levels of postoperative pain, while negative affect is associated with higher levels of pain. More recent research asks if subscales of positive affect such as calm, well-being, and vigor could be related to pain experiences. Studies of postoperative pain in children relating to positive and negative affect are limited, with none examining the connection between positive affect subscales and negative affect subscales (anger, anxiety, and depression) and children’s pain. This study addresses that gap by uncovering the relationships between the aforementioned subscales to postoperative pain in children. This study was …

Utilizing Best Practices Of 3d-Modeling And Printing In Veterinary Medicine To Analyze Elbow Incongruity Of A Maltese Canine, Johnny Altwal

Student Scholar Symposium Abstracts and Posters

Research on the application of 3D-printed models in human medicine is extensive, but it is relatively new for veterinary medicine. With the increased numbers of certified veterinary radiologists and animal imaging facilities, best practices in 3D model design and printing can be explored. This project was two-fold. First, an encompassing literature review was generated, outlining the development and uses of computer-generated 3D models in connection to their applications in veterinary medicine. Accurate renderings of an animal’s anatomy can be used to train new students, educate clients on their pets’ needs, and guide veterinarian surgical approaches. Several different cases were explored …

Mode Of Delivery And Infant Cognitive Development, Madison Olson, Laura M. Glynn

Student Scholar Symposium Abstracts and Posters

The rate of nonindicated cesarean births is increasing each year within the United States. Although cesarean delivery can function as a life- saving intervention, emerging evidence suggests that it may also be associated with deleterious developmental consequences for the child. Here we test the hypothesis that mode of delivery is associated with cognitive development during infancy. 229 pregnant women were recruited and their infants’ cognitive development was assessed at 6, 12 and 24 months with the Bayley Scales of Infant Development. Medical charts were reviewed by obstetric nurses to determine prenatal medical risk and birth outcomes, including mode of delivery. …

Demographic Predictors Of Adult Behaviors In The Pediatric Postoperative Environment, Natasha H. Hikita, Amber Osorno, Carlie Taurosa, Michelle A. Fortier, Zeev N. Kain, Brooke N. Jenkins

Student Scholar Symposium Abstracts and Posters

Over 85% of children experience postoperative pain. If poorly treated, pediatric postoperative pain may lead to various negative health outcomes. Adult behaviors may be associated with child experiences in the postoperative environment. For example, adult behaviors such as distraction, humor, and coping advice divert a child’s attention away from their pain and thus, may significantly reduce child postoperative distress. In contrast, adult behaviors such as empathy, reassurance, and apology direct a child’s attention towards their pain which may increase a child’s overall postoperative distress. Moreover, patient demographic factors, like child ethnicity, may significantly alter the frequency of use of these …

The Effects Of Zoledronate And Sleep Deprivation On The Distal Femur Trabecular Thickness Of Ovariectomized Rats: Application Of Different Statistical Methods, Erin Nolte

Student Scholar Symposium Abstracts and Posters

Osteoporosis is a disease that causes the degradation of bone, leading to an increased risk of fracture. 1 in 3 women over the age of 50 will be affected by Osteoporosis. This study aims to understand how bone is affected by sleep deprivation in estrogen-deficient rats, and how Zoledronate might negate the inimical effects of sleep deprivation on bone. As bone mineral density (BMD) is a crude evaluation of the architectural changes seen in Osteoporosis, trabecular thickness may serve as a better single evaluation of bone health. 31 Wistar female rats were ovariectomized and separated into 4 random groups. The …

Searching For Neural Mechanisms Of Social Cognition, Chandler Siemonsma, Cristina Uribe, Louanne Boyd, Aaron Schurger, Deanna Hughes, Tian Lan

Student Scholar Symposium Abstracts and Posters

Social cognition involves the integration and pruning of perceptual information which leads to the formation of an abstract representation, which is also known as the perceptual gist. This study examined 87 differences in visual perception of Mooney face stimuli of differing sizes and the relationship to gist formation in ten individuals with autism compared to neurotypical controls. Parents of both groups completed the Social Responsiveness Scale (SRS-2) to assess social functioning in real-world scenarios.

A New Spatially-Resolved Method To Sample Biofilms From Drinking Water Fountains, Yi Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

A drinking fountain, also called a water fountain, is a facility designed to provide drinking water in public space. It consists of a basin and a spout. The users need to bend down to the stream to collect or drink water. The history of water fountains can be traced back to ancient Rome. Even before potable water was provided to individual homes, water for drinking was already made available to citizens through access to public fountains. Nowadays, drinking water fountains usually exist in public places, like schools, hospitals, and libraries. Many jurisdictions in the United States require drinking fountains to …

Network Meta-Analysis To Compare Venaseal With Other Superficial Venous Therapies For Chronic Venous Insufficiency., Raghu Kolluri, Janice Chung, Sue Kim, Nibir Nath, Bhoomika Bajaj Bhalla, Tarun Jain, Joseph Zygmunt, Alun Davies

Heart and Vascular Articles

OBJECTIVE: Several randomized controlled trials (RCTs) have compared different interventions for chronic venous insufficiency (CVI) management, but mixed comparison of these interventions is lacking. The aim of this network meta-analysis was to compare VenaSeal closure system (Medtronic, Minneapolis, Minn) with endovenous laser ablation (EVLA), radiofrequency ablation (RFA), mechanochemical ablation, sclerotherapy, and surgery for management of CVI to achieve anatomic success (complete closure of treated vein within 6 months after intervention) as the primary outcome and health-related quality of life (HRQoL; EuroQol-5 Dimension, Aberdeen Varicose Vein Questionnaire), Venous Clinical Severity Score (VCSS), pain scores, and adverse events as secondary outcomes.

METHODS: …

Bispecific Human Il2-Ccr4 Immunotoxin Targets Human Cutaneous T-Cell Lymphoma, Haoyu Wang, Zhaohui Wang, Huiping Zhang, Zeng Qi, Ariel C Johnson, David Mathes, Elizabeth A Pomfret, Erin Rubin, Christene A Huang, Zhirui Wang

Faculty, Staff and Student Publications

The majority of clinically diagnosed cutaneous T‐cell lymphomas (CTCL) highly express the cell‐surface markers CC chemokine receptor 4 (CCR4) and/or CD25. Recently, we have developed diphtheria toxin‐based recombinant Ontak®‐like human IL2 fusion toxin (IL2 fusion toxin) and anti‐human CCR4 immunotoxin (CCR4 IT). In this study, we first compared the efficacy of the CCR4 IT vs IL2 fusion toxin for targeting human CD25+CCR4+ CTCL. We demonstrated that CCR4 IT was more effective than IL2 fusion toxin. We further constructed an IL2‐CCR4 bispecific IT. The bispecific IT was significantly more effective than either IL2 fusion toxin or CCR4 IT alone. The bispecific …

Baclofen-Induced Changes In The Resting Brain Modulate Smoking Cue Reactivity: A Double-Blind Placebo-Controlled Functional Magnetic Resonance Imaging Study In Cigarette Smokers, Ariel Ketcherside, Kanchana Jagannathan, Sudipto Dolui, Nathan Hager, Nathaniel Spilka, Chaela Nutor, Hengyi Rao, Teresa Franklin, Reagan Wetherill

Psychology Faculty Publications

Objective: Smoking cue-(SC) elicited craving can lead to relapse in SC-vulnerable individuals. Thus, identifying treatments that target SC-elicited craving is a top research priority. Reduced drug cue neural activity is associated with recovery and is marked by a profile of greater tonic (resting) activation in executive control regions, and increased connectivity between executive and salience regions. Evidence suggests the GABA-B agonist baclofen can reduce drug cue-elicited neural activity, potentially through its actions on the resting brain. Based on the literature, we hypothesize that baclofen’s effects in the resting brain can predict its effects during SC exposure.

Methods: In this longitudinal, …

Preferences In Information Processing, Marginalized Identity, And Non-Monogamy: Understanding Factors In Suicide-Related Behavior Among Members Of The Alternative Sexuality Community, Robert J. Cramer, Jennifer Langhinrichsen-Rohling, Andrea R. Kaniuka, Corrine N. Wilsey, Annelise Mennicke, Susan Wright, Erika Montanaro, Jessamyn Bowling, Kristin E. Heron

Psychology Faculty Publications

Suicide-related behavior (SRB) is a mental health disparity experienced by the alternative sexuality community. We assessed mental health, relationship orientation, marginalized identities (i.e., sexual orientation minority, gender minority, racial minority, ethnic minority, and lower education), and preferences in information processing (PIP) as factors differentiating lifetime SRB groups. An online cross-sectional survey study was conducted in 2018. Members of the National Coalition for Sexual Freedom (NCSF; n = 334) took part. Bivariate analyses identified the following SRB risk factors: female and transgender/gender non-binary identity, sexual orientation minority identity, lower education, suicide attempt/death exposure, Need for Affect (NFA) Avoidance, depression, and anxiety. …

A Call For Grounding Implicit Bias Training In Clinical And Translational Frameworks, Nao Hagiwara, Frederick W. Kron, Mark W. Scerbo, Ginger S. Watson

Psychology Faculty Publications

Since the publication of Unequal Treatment in 2003,¹ the number of studies investigating the implicit bias of health-care providers and its troubling consequences has increased exponentially. Bias can occur in all three psychological components: affects (ie, prejudice), cognition (ie, stereotypes), and behaviour (ie, discrimination). Implicit bias refers to prejudicial attitudes towards and stereotypical beliefs about a particular social group or members therein. These prejudicial attitudes and stereotypical beliefs are activated spontaneously and effortlessly, which often result in discriminatory behaviours.² This definition is consistent with how implicit bias is defined in psychology³ and in literature on health disparities. …

Dietary Fat And Sugar Differentially Affect Β-Adrenergic Stimulation Of Cardiac Erk And Akt Pathways In C57bl/6 Male Mice Subjected To High-Calorie Feeding, Sadia Ashraf, Gizem Yilmaz, Xu Chen, Romain Harmancey

Faculty, Staff and Student Publications

BACKGROUND: High dietary fat and sugar promote cardiac hypertrophy independently from an increase in blood pressure. The respective contribution that each macronutrient exerts on cardiac growth signaling pathways remains unclear.

OBJECTIVE: The goal of this study was to investigate the mechanisms by which high amounts of dietary fat and sugar affect cardiac growth regulatory pathways.

METHODS: Male C57BL/6 mice (9 wk old; n = 20/group) were fed a standard rodent diet (STD; kcal% protein-fat-carbohydrate, 29-17-54), a high-fat diet (HFD; 20-60-20), a high-fat and high-sugar Western diet (WD; 20-45-35), a high-sugar diet with mixed carbohydrates (HCD; 20-10-70), or a high-sucrose diet …

Efficacy Of Antibiotic Therapy In Those Diagnosed With Chronic Lower Back Pain, Alexander Marcel Lee

Physician Assistant Scholarly Project Papers

Chronic back pain affects approximately eight percent of the American population, yet no treatment has been agreed upon universally. Recent studies suggest that between 20-30 percent of lower back pain cases are caused by a low-virulence bacterial infection of the intervertebral disks in those who suffered disc herniation. This scholarly project is to investigate: In patients with chronic lower back pain and Modic changes after disc herniation, what is the effect of antibiotic therapy on reducing pain symptoms compared to placebo. This literature review used the following electronic databases: ClinicalKey, Cochrane Library, Embase, and PubMed. Keywords and mesh terms refined …

Hpv Vaccine In Adolescents: How To Increase Uptake, Natasha Richesin

Physician Assistant Scholarly Project Papers

The human papillomavirus (HPV) is a sexually transmitted virus that affects both males and females of all ages. An HPV vaccine was developed to help protect against harmful infections caused by the virus. This literature review focuses on the relationship between the HPV vaccine and its low uptake from untoward events, misinformation surrounding the vaccine, and different education methods. PubMed, Clinical Key, and Cochrane electronic databases are used for the literature review. A comprehensive literature review was conducted, and articles utilized were based on the age of the population being 11 to 29 years old, the HPV vaccine’s involvement in …