Medicine and Health Sciences Commons^™

A Health Care Comparison Of Areas In Ghana And In The United States, Lindsey Matsumoto

Honors Projects

The health care system is an important factor for the well-being of the human population all around the world, and yet, health care can differ greatly depending on a variety of factors including location and culture. When referring to health care, it is appropriate to include skilled physicians, hospitals, care clinics, and medical equipment. This article conducts a literature review that compares the health care systems of two countries, the Republic of Ghana and the United States of America. This information is relevant for not only expanding one’s knowledge, but also for travel purposes, as both countries have highly populated …

Systematic Review With Meta-Analysis: Prevalence Of Prior And Concurrent Barrett’S Oesophagus In Oesophageal Adenocarcinoma Patients, Mimi C Tan, Nabil Mansour, Donna L White, Amy Sisson, Hashem B El-Serag, Aaron P Thrift

Library Staff Publications

BACKGROUND: The proportions of patients with oesophageal adenocarcinoma (OAC) diagnosed by Barrett's oesophagus surveillance or with pre-existing Barrett's oesophagus are unclear.

AIM: To estimate the prevalence of prior and concurrent Barrett's oesophagus diagnosis among patients with OAC or oesophagogastric junction adenocarcinomas (OGJAC).

METHODS: We searched PubMed and Embase to identify studies published 1966-1/8/2020 that examined the prevalence of prior (≥6 months) or concurrent Barrett's diagnosis (at cancer diagnosis) among OAC and OGJAC patients. Random effects models estimated overall and stratified pooled prevalence rates.

RESULTS: A total of 69 studies, including 33 002 OAC patients (53 studies) and 2712 patients with …

Polycystic Ovarian Syndrome: Causes, Complications, And Treatments, Toni Tornberg

Biomedical Sciences Undergraduate Research

Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder prevalent in 6-10% of reproductive age women. The purpose of this review paper is to describe both genetic and environmental causes and symptoms of PCOS. Additionally, to summarize the complications women face with a PCOS diagnosis and present treatment and management options. The information forming this paper was compiled from various online heath journals. The results show that both clinical and biochemical examinations are used for the diagnosis of PCOS while the exact cause is unknown. Genetics and environmental factors, specifically the intrauterine environment, are discussed as causes. Management and treatment options …

Microbial Experience Influences Tumor- Infiltrating T Lymphocytes, Hanna Groeber

Masters Theses

Immune cells, including T cells, have been used for anti-cancer therapy with varying degrees of success. One potential reason for immunotherapy failures in clinical trials may be that typical specific pathogen free (SPF) mice do not accurately replicate human microbial experience, which has important influence on shaping the adaptive immune response. Recently, several previous studies have shown that the immune system of SPF mice more closely resembles newborn human immunity, whereas immune systems from mice exposed to diverse pathogens more closely reflect adult human immunity.

To study the impact of microbial experience on the immune response, we have adopted a …

Barriers And Facilitators To Voting For People With Disabilities In Michigan Rural Communities, Christian Aguilar-Quiroz, Kaylyn Brzys, Chris Paclibar, Kyle Witte

Community Based

Objective: In this study, we sought to investigate and obtain data on the perceived barriers and facilitators that rural Michigan residents with disabilities face throughout the voting process.

Method: We conducted two separate focus groups in two different rural areas of Michigan asking a series of semi-structured questions about the participants’ voting experiences. We obtained recorded interviews, qualitative data, of their answers to these prepared questions.

Results: Physical accessibility was limited by poor lighting for people with low vision problems and a lack of accommodations for those who are not able to stand for a prolonged time while waiting in …

The Perceived Effects Of Occupational Therapy Interventions For Those Who Recently Transitioned From Homelessness To Permanent Housing, Sydney Krol, Madison Muir, Katie Johnson, Kristin Hazlett, Kaelyn Hughs

Community Based

OBJECTIVE. The study's objective was to examine the perceived effects of occupational therapy services for families who have recently transitioned to permanent housing from a period of homelessness.

METHOD. The study used a qualitative research design. One family received occupational therapy interventions administered by occupational therapy student researchers. Exit interview was audio recorded and transcribed.Themes and codes were derived from the transcription.

RESULTS. Three themes and seven codes were identified, which encompassed the participants perception of the intervention. The themes were lifestyle transformation, mindset development, and client centered care. The codes were organization and planning, roles and routines, goal progression, …

Occupation-Based Learning Modules In Preparation For Parole: A Program Evaluation, Alisha Cheyne, Gabrielle Martino, Elizabeth Vander Wall, Natalie Wallace

Community Based

A qualitative research study was conducted that examined occupational therapy students’ fieldwork rotation at Muskegon Correctional Facility, where they implemented a 15-week pre-parole program. One focus group with three participants was conducted. Transcription, coding, and theming followed, providing five themes; restriction, OT perceptions, learning styles, future needs, and relationships. Results showed areas of needs within this population, ways occupational therapy can address this need, and general improvements that can be made to pre-release programs.

Exploratory Study Of Children With Sensory Processing Disorder (Spd) Without An Autism Spectrum Disorder (Asd) Diagnosis, Breanna Williams, Lauren Brown, Kendall Grzywa, Emma Green

Pediatrics

The purpose of this study was to explore the prevalence of children with sensory processing disorder (SPD) without an autism spectrum disorder (ASD) diagnosis. Examples of these diagnoses include attention deficit hyperactivity disorder (ADHD), cerebral palsy (CP), posttraumatic stress disorder (PTSD), Oppositional Defiant Disorder (ODD), and Reactive Attachment Disorder (RAD). This was an exploratory descriptive study that gathered quantitative data through the Sensory Processing Measure (SPM) Home Form. The SPM Home Form was provided by occupational therapy (OT) students and completed by the child’s caregiver. The scores fell into three interpretive ranges: Typical, Some Problems, and Definite Dysfunction. Researchers hypothesized …

Caregiver Perspective On Sensory Diet And Therapeutic Listening For Children With Autism Spectrum Disorder And/Or Sensory Processing Disorder, Mikayla M. Brett, Lynette Zulquairnain, Katlyn Ribant

Pediatrics

Due to the high prevalence of Autism Spectrum Disorder (ASD) and Sensory Processing Disorder (SPD), there is a high demand for more research on effective interventions in order to improve quality of life and engagement in meaningful occupations for individuals with ASD and/or SPD. Sensory Diet (SD) and Therapeutic Listening © (TL) are interventions commonly utilized with individuals with ASD and/or SPD, however, there is limited research on their combined use. The purpose of this study is to determine the effectiveness of the combined occupational therapy (OT) interventions of SD and TL on the occupational performance of children with ASD …

Diagnosis And Management Of Malignant Peripheral Nerve Sheath Tumors: Current Practice And Future Perspectives, Bethany C Prudner, Tyler Ball, Richa Rathore, Angela C Hirbe

2020-Current year OA Pubs

One of the most common malignancies affecting adults with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the malignant peripheral nerve sheath tumor (MPNST), a highly aggressive sarcoma that typically develops from benign plexiform neurofibromas. Approximately 8-13% of individuals with NF1 will develop MPNST during young adulthood. There are few therapeutic options, and the vast majority of people with these cancers will die within 5 years of diagnosis. Despite efforts to understand the pathogenesis of these aggressive tumors, the overall prognosis remains dismal. This manuscript will review the current understanding of the cellular and molecular progression of MPNST, diagnostic …

Disease And Treatment Patterns Among Patients With Pouch-Related Conditions In A Cohort Of Large Tertiary Care Inflammatory Bowel Disease Centers In The United States, Edward L Barnes, Laura Raffals, Millie D Long, Gaurav Syal, Maia Kayal, Ashwin Ananthakrishnan, Benjamin Cohen, Joel Pekow, Parakkal Deepak, Jean-Frederic Colombel, Hans H Herfarth, Robert S Sandler

2020-Current year OA Pubs

BACKGROUND: Gaps exist in our understanding of the clinical course of pouch-related disorders.

METHODS: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch.

RESULTS: Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery.

CONCLUSIONS: Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system.

On The Nature Of Monozygotic Twin Concordance And Discordance For Autistic Trait Severity: A Quantitative Analysis, Lauren Castelbaum, Chad M Sylvester, Yi Zhang, Qiongru Yu, John N Constantino

2020-Current year OA Pubs

The characterizing features of autism spectrum disorder (ASD) are continuously distributed in nature; however, prior twin studies have not systematically incorporated this knowledge into estimations of concordance and discordance. We conducted a quantitative analysis of twin-twin similarity for autistic trait severity in three existing data sets involving 366 pairs of uniformly-phenotyped monozygotic (MZ) twins with and without ASD. Probandwise concordance for ASD was 96%; however, MZ trait correlations differed markedly for pairs with ASD trait burden below versus above the threshold for clinical diagnosis, with R

Transcriptomes From German Shepherd Dogs Reveal Differences In Immune Activity Between Atopic Dermatitis Affected And Control Skin, K Tengvall, K Bergvall, M Olsson, B Ardesjö-Lundgren, F H G Farias, M Kierczak, Å Hedhammar, K Lindblad-Toh, G Andersson

2020-Current year OA Pubs

Canine atopic dermatitis (CAD) is an inflammatory and pruritic allergic skin disease with both genetic and environmental risk factors described. We performed mRNA sequencing of non-lesional axillary skin biopsies from nine German shepherd dogs. Obtained RNA sequences were mapped to the dog genome (CanFam3.1) and a high-quality skin transcriptome was generated with 23,510 expressed gene transcripts. Differentially expressed genes (DEGs) were defined by comparing three controls to five treated CAD cases. Using a leave-one-out analysis, we identified seven DEGs: five known to encode proteins with functions related to an activated immune system (CD209, CLEC4G, LOC102156842 (lipopolysaccharide-binding protein-like), LOC480601 (regakine-1-like), LOC479668 …

Impact Of Vancomycin-Induced Changes In The Intestinal Microbiota On The Pharmacokinetics Of Simvastatin, Jung Sunwoo, Sang Chun Ji, Andrew Hyoungjin Kim, Kyung-Sang Yu, Joo-Youn Cho, In-Jin Jang, Seunghwan Lee

2020-Current year OA Pubs

The pharmacokinetic (PK) properties of drugs are affected in several ways by interactions with microbiota. The aim of this study was to investigate the effects of oral vancomycin on the gut microbiota and, consequently, on the PKs of simvastatin. An open-label, single arm, sequential crossover study was conducted in six healthy Korean male subjects. After 6 days on a control diet, simvastatin 40 mg was orally administered to the subjects before and after 1 week of oral vancomycin treatment. Blood samples for PK analysis and fecal samples for metagenomic and metabolomic analyses were collected. After vancomycin treatment, the richness of …

Major Septal Defects: Comparative Study Of Down Syndrome And Non-Down Syndrome Infants, Before And After Surgery, Saleha Aziz, Maaha Ayub, Laiba Masood, Muneer Amanullah, Rukhsana Hameed, Shiraz Hashmi, Waris Ahmad

Medical College Documents

Objective: To compare pre-operative, intra-operative, and post-operative parameters in Down syndrome (DS) and non-DS patients with atrioventricular septal defects (AVSD) and inlet ventricular septal defects (VSD) in a tertiary care hospital in Pakistan.
Methods: We conducted a retrospective study at Aga Khan University, Pakistan. All complete atrioventricular septal defect (CAVSD), partial atrioventricular septal defect (PAVSD), and VSD with inlet extension surgical cases from January 2007 to January 2019 were included. Patients with congenital heart diseases other than those listed above were excluded.
Results: In 61 cases, 18 had DS. Median age, mean body surface area (BSA), and height were lower …

Aggressive Angiomyxoma In The Ischiorectal Fossa, Asra Wahid, Abdul Hakeem, Sadaf Khan

Medical College Documents

Aggressive Angiomyxoma (AA) is a soft tissue tumour that principally affects women of the reproductive age, primarily involving the pelvis and the perineum. Despite being slow growing, it is classified as aggressive due to its locally infiltrative nature and high recurrence. It is rare, often asymptomatic and is misdiagnosed. However, it has characteristic features on radiographic imaging. Complete surgical resection is the ideal approach to treat AA. We report a case of an aggressive angiomyxoma in a 17 year old female, located in the ischiorectal fossa and diagnosed incidentally on a magnetic resonance imaging (MRI). The lesion was excised without …

Building A Contextually-Relevant Understanding Of Resilience Among African American Youth Exposed To Community Violence., Briana Woods-Jaeger, Emily Siedlik, Amber Adams, Kaitlin Piper, Paige O'Connor, Jannette Berkley-Patton

Manuscripts, Articles, Book Chapters and Other Papers

Studies consistently demonstrate that African American youth experience disproportionate levels of community violence, which is associated with negative health and well-being outcomes among these youth. The frequency and severity of community violence exposure is a unique challenge for these youth and requires tailored approaches to promote resilience after community violence exposure. However, limited research exists that operationalizes resilience after community violence based on the unique context and lived experience of African American youth. Developing a more contextually relevant understanding of resilience is critical to reducing health inequities experienced by African American youth and promoting their well-being. Five focus groups were …

Mealtime Insulin Bolus Score Increases Prior To Clinic Visits In Youth With Type 1 Diabetes., Andrew Mcconville, Amy E. Noser, Mark A. Clements, Susana R. Patton

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Multiple studies confirm the occurrence of 'white coat adherence' (WCA), a term describing an increase in engagement with self-care tasks just prior to a scheduled clinic appointment, across cohorts with multiple chronic conditions. In youth with type 1 diabetes (T1D), research also shows an increase in self-monitoring blood glucose frequency ahead of youths' clinic visits. While studies show preliminary evidence for the occurrence of WCA in youth with T1D, no study has examined the effect of WCA and mealtime insulin dosing behaviors in youth with T1D. The frequency of mealtime insulin bolusing score (BOLUS) is an objective measure of …

Igf1r Immunohistochemistry In Ewing's Sarcoma As Predictor Of Response To Targeted Therapy., Elizabeth Gonzalez, Marilyn Bui, Atif Ahmed

Manuscripts, Articles, Book Chapters and Other Papers

Objectives: Ewing's sarcoma is an aggressive malignancy of bone and soft tissue in children and young adults. Despite advances in modern therapy, metastasis can occur and results in high mortality. The objective of this study was to identify whether the signaling transduction proteins, insulin growth factor receptor (IGF1R) and S6 kinase (S6K), can predict poor prognosis in Ewing's sarcoma.

Methods: After the Institutional Research Board approval, immunohistochemical experiments on tissue microarray slides containing 32 archived Ewing's sarcoma tumor samples were performed with antibodies against IGF1Rb and p-S6K. Immunohistochemical staining results were correlated with patients' clinical data including clinical stage and …

Palbociclib Treatment Alters Nucleotide Biosynthesis And Glutamine Dependency In A549 Cells, Lindsey R. Conroy, Pawel Lorkiewicz, Liqing He, Xinmin Yin, Xiang Zhang, Shesh N. Rai, Brian F. Clem

Neuroscience Faculty Publications

Background

Aberrant activity of cell cycle proteins is one of the key somatic events in non-small cell lung cancer (NSCLC) pathogenesis. In most NSCLC cases, the retinoblastoma protein tumor suppressor (RB) becomes inactivated via constitutive phosphorylation by cyclin dependent kinase (CDK) 4/6, leading to uncontrolled cell proliferation. Palbociclib, a small molecule inhibitor of CDK4/6, has shown anti-tumor activity in vitro and in vivo, with recent studies demonstrating a functional role for palbociclib in reprogramming cellular metabolism. While palbociclib has shown efficacy in preclinical models of NSCLC, the metabolic consequences of CDK4/6 inhibition in this context are largely unknown.

Methods

In …

Thrower's Exostosis Of The Shoulder: A Systematic Review With A Novel Classification, Michael T. Freehill, Sandeep Mannava, Laurence D. Higgins, Alexandre Lädermann, Austin V. Stone

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background: A variety of thrower's exostoses are grouped under the term Bennett lesion, which makes understanding diagnosis and treatment difficult.

Purpose: To identify all types of reported thrower's and overhead athlete's exostoses and categorize them into a classification system to allow a morphology-based classification.

Study Design: Systematic review; Level of evidence, 4.

Methods: A systematic review of all articles pertaining to Bennett lesions and thrower's exostosis was performed. The classification and treatments were evaluated to describe the types, proposed causes, diagnosis, and treatment options.

Results: A total of 27 studies were included in the systematic review. The anatomic locations …

Predictors Of Biologic Use And Satisfaction Among Patients With Psoriasis: An Analysis And Geographic Visualization Of The 2016 And 2017 National Psoriasis Foundation Annual Surveys, Clinton W. Enos, Hadiza I. Galadima, Arjun Saini, Stacie Bell, Michael Siegel, Abby S. Van Voorhees

Community & Environmental Health Faculty Publications

Background: There are an increasing number of biologic therapies approved for the treatment of psoriasis. Previous reports have identified undertreatment as a concern in the United States. Undertreatment has been associated with decreased patient satisfaction and increased morbidity.

Objectives: Assess biologic use and satisfaction among respondents to the 2016 and 2017 National Psoriasis Foundation (NPF) Annual Surveys.

Methods: Retrospective data analysis of the 2016 and 2017 NPF Annual Survey responses from individuals with psoriasis. ArcGIS Pro software was utilized to generate maps and perform an optimized hot spot analysis of moderate-to-severe psoriasis and biologic use.

Results: …

Llusd Articulator - Volume 31, Number 1, Loma Linda University School Of Dentistry

Articulator (Dentistry)

Contents:

6 | Dean's Message
10 | Curriculum transformation continues
11 | Holli Riter appointed Chief Medical Officer
15 | Patient Layla's "jaw in a day"
17 | Just-in-time Homecoming 2020
26 | From the Class of 1970, a story of service
27 | LLUSD manages a pandemic
33 | Imaging Clinic acquires NewTom VGi EVO
35 | Lane Thomsen honored for CE contributions

Outbreak Of Novel Coronavirus (2019-Ncov): The First Three-Month Experience Of Anesthesiologists In Thai University Hospital, Benjamas Kiatkasemsan, Mutita Chaichalothorn, Titipon Payongsri, Somrat Charuluxananan

Chulalongkorn Medical Journal

No abstract provided.

Bioceramic Resonance Induced Extrasensory Perception Or Altered State Of Consciousness: A Pilot Study Of Taiwan, Ting Kai Leung

Chulalongkorn Medical Journal

No abstract provided.

Effect Of A Family Member Support Program On Exercise Behavior Among Family Members With Hypertensive Patients, Warangkana Sonjai, Yupa Jewpattanakul, Rukchanok Koshakri

Chulalongkorn Medical Journal

No abstract provided.

Outcomes Of Hyperbaric Oxygen Therapy For Central Retinal Artery Occlusion In Somdech Phra Pinklao Hospital, Chatchadaporn Kraisornpornsan, Thosporn Vimolkej, Napang Kedkovid

Chulalongkorn Medical Journal

No abstract provided.

Impact Of A Multimodal Intervention Program On Hand Hygiene Compliance At Bangkok Tertiary Care Hospital, Wipaporn Natalie Songtaweesin, Suvaporn Anugulruengkit, Rujipat Samransamruajkit, Darintr Sosothikul, Mayuree Prinyawat, Ornanong Tangsrijitdee, Anry Nakphunsung, Patchareeyawan Srimuan, Jiratchaya Sophonphan, Chitsanu Pancharoen

Chulalongkorn Medical Journal

No abstract provided.

Effect Of Social Skills Training Program On Social Functioning In Patients With Major Depressive Disorder In Outpatient Psychiatric Department, King Chulalongkorn Memorial Hospital, Vanussanun Jannim, Peeraphon Lueboonthavatchai

Chulalongkorn Medical Journal

No abstract provided.

Using Spatial Methods To Better Understand Food Insecurity And Snap Under-Participation In Texas, Ryan Ramphul

Dissertations and Theses (Open Access)

The overall objective of this research is to use spatial methods to better understand food insecurity and SNAP under-participation in Texas. Paper 1 assesses whether a sample of community dwelling Medicare and Medicaid beneficiaries, who screen positive for food insecurity at healthcare locations in Harris County, exhibit a spatial pattern in terms of where they live. In other words, it tests whether or not there are statistically significant neighborhood hot spots or cold spots of food insecurity against a null hypothesis of complete spatial randomness. This approach is novel because it uses address-level data on patients who report being food …