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Articles 12061 - 12090 of 328539
Full-Text Articles in Medicine and Health Sciences
Women With Moderate Anaemia Prior To Conception Benefited Most From Nutrition Interventions: A Secondary Analysis Of The Women First Preconception Maternal Nutrition Trial, Sumera Aziz Ali, Ka Kahe, Jeanine Genkinger, Linda Valeri, Sarah Saleem, Saleem Jessani, Robert Goldenberg, Jamie Westcott, Jennifer Kemp, Ana Garces, Lester Figueroa, Shivaprasad Goudar, Sangappa Dhaded, Richard Derman, Antoinette Tshefu Kitoto, Adrien Lokangaka, Melissa Bauserman, Elizabeth Mcclure, Marion Koso-Thomas, Louise Kuhn, Nancy Krebs
Women With Moderate Anaemia Prior To Conception Benefited Most From Nutrition Interventions: A Secondary Analysis Of The Women First Preconception Maternal Nutrition Trial, Sumera Aziz Ali, Ka Kahe, Jeanine Genkinger, Linda Valeri, Sarah Saleem, Saleem Jessani, Robert Goldenberg, Jamie Westcott, Jennifer Kemp, Ana Garces, Lester Figueroa, Shivaprasad Goudar, Sangappa Dhaded, Richard Derman, Antoinette Tshefu Kitoto, Adrien Lokangaka, Melissa Bauserman, Elizabeth Mcclure, Marion Koso-Thomas, Louise Kuhn, Nancy Krebs
Global Health Articles
INTRODUCTION: The Women First (WF) Preconception Maternal Nutrition trial found greater benefits of small-quantity lipid-based nutrient supplements (SQ-LNS) for intrauterine growth among anaemic versus non-anaemic women at preconception. We investigated whether the benefits of SQ-LNS in improving markers of intrauterine growth occurred evenly across the mild to moderate spectrum of pre-pregnancy anaemia.
METHODS: We analysed WF data (n=2443 maternal-newborn dyads) from Pakistan, India, Guatemala and the Democratic Republic of Congo. Women received SQ-LNS either ≥3 months preconception through pregnancy (Arm 1); starting in the late first trimester (Arm 2); or not at all (Arm 3: control), with all supplementations discontinued …
Late-Career Transitions From Private Practice To Academic Dermatology: Financial Drivers, Professional Rewards, And Practical Steps, Joshua R. Jennings, Thomas Helm, Jeremy D. Jackson, Robert T. Brodell, N A
Late-Career Transitions From Private Practice To Academic Dermatology: Financial Drivers, Professional Rewards, And Practical Steps, Joshua R. Jennings, Thomas Helm, Jeremy D. Jackson, Robert T. Brodell, N A
School of Medicine
Independent practice dermatology once promised near-total clinical autonomy and robust profit margins, yet more and more dermatologists have been leaving their “private” practices and contemplating a mid- or late-career move to academia [1]. Openings are available! Over the last 25 years, many academic health centers have evolved to engage clinician educators in support of their educational mission, which requires more clinical rotations for larger student bodies and to provide income to offset losses in research support [23, 39]. Leaving private practice is neither anecdotal nor sentimental; it reflects quantifiable changes in reimbursement, overhead, and the …
The Impact Of Bilingual Home Literacy Practices On The Emergent Literacy Skills Of Hispanic Youth, Sophie Watkins Roberts
The Impact Of Bilingual Home Literacy Practices On The Emergent Literacy Skills Of Hispanic Youth, Sophie Watkins Roberts
Student Theses and Dissertations
This study examined the impact of bilingual home literacy environments (HLEs) on the emergent literacy skills of Hispanic children enrolled in an after-school program in Jonesboro, Arkansas. Thirteen Spanish–English bilingual children in kindergarten through third grade and their parents participated. Parent-reported data were collected using an adapted Spanish–English Reading Questionnaire (SER-Q), and children’s literacy skills were assessed with the Dynamic Indicators of Basic Early Literacy Skills (DIBELS) and the Spanish Reading Inventory–Second Edition (SRI-2). Descriptive and correlational analyses explored within- and cross-language relationships between HLE practices and early reading performance. Results indicated that even modest access to books and daily …
Communication Disorders Graduate Student: Perspective Of Voice, Maycie Brentney Terrell / Blankenship
Communication Disorders Graduate Student: Perspective Of Voice, Maycie Brentney Terrell / Blankenship
Student Theses and Dissertations
This study examined the influence of training in SPEAK OUT!® on the perceptual ratings of voice and speech made by communication disorders (CD) graduate students. The purpose of this study was to investigate the influence of SPEAK OUT!® training by comparing those who have undergone SPEAK OUT!® training with those who have not. To address this, 36 participants who attend communication disorders graduate programs within the United States were recruited. Data were collected through a Qualtrics survey distributed via email and analyzed using the Statistical Package for the Social Sciences (SPSS). The findings indicate that perceptual ratings across most voice …
Band Directors: Risk Factors For Vocal Dysphonia, Brianna Bumpous
Band Directors: Risk Factors For Vocal Dysphonia, Brianna Bumpous
Student Theses and Dissertations
The voice is an extensively utilized tool for high school marching band directors, which places them at risk for vocal disorders due to the profession's demands. Responsibilities such as leading rehearsals, teaching instrumental techniques, and directing require extensive vocal use in acoustically challenging environments, including football fields, large open indoor practice areas, and loud acoustic spaces. Research exists regarding vocal health for teachers, coaches, and musicians, yet little research has been conducted for high school marching band directors. This non-experimental exploratory study aimed to analyze if high school marching band directors experience dysphonia due to their occupation and if female …
Psychological Impacts Of Caring For Individuals With Fluent Versus Nonfluent Aphasia, Allisyn Rae Converse
Psychological Impacts Of Caring For Individuals With Fluent Versus Nonfluent Aphasia, Allisyn Rae Converse
Student Theses and Dissertations
This investigation sought to explore the mental health differences between caregivers of individuals with fluent aphasia versus caregivers of individuals with nonfluent aphasia with a focus on their levels of depression, anxiety, and stress. This study had a quantitative, non-experimental between group research design, utilizing a Qualtrics survey including the Hospital Anxiety and Depression Scale and the Perceived Stress scale to collect all data. Both caregivers of individuals with nonfluent and fluent aphasia can experience psychological impacts of serving as a caregiver such as elevated stress, anxiety, and depression. However, this study reveals that caregivers of individuals with nonfluent aphasia …
The Knowledge And Perceptions Of Noise-Induced Hearing Loss Among Agricultural Education Students, Madyson Hufstedler
The Knowledge And Perceptions Of Noise-Induced Hearing Loss Among Agricultural Education Students, Madyson Hufstedler
Student Theses and Dissertations
Noise-induced hearing loss (NIHL) is a preventable yet widespread occupational hazard, especially among agricultural workers who are regularly exposed to high levels of noise from equipment, machinery, and firearms (Lander et al., 2007; Milz et al., 2008). Young and future farmers may be particularly vulnerable due to early and prolonged exposure combined with limited awareness about the risks of noise and the importance of hearing protection (Balanay & Kearney, 2015; Martin et al., 2006). This study examined the perceptions and knowledge of NIHL among 83 students (76 high school and 7 college) in northern Arkansas and southern Missouri. A pretest–posttest …
Cv: Erica Brkovic (Speech-Language Pathology), Erica Brkovic
Cv: Erica Brkovic (Speech-Language Pathology), Erica Brkovic
Rehabilitation Sciences Department Curricula Vitae
No abstract provided.
Using The Linear References From The Pangenome To Discover Missing Autism Variants, Yang Sui, Jiadong Lin, Michelle D Noyes, Youngjun Kwon, Isaac Wong, Nidhi Koundinya, William T Harvey, Mei Wu, Kendra Hoekzema, Katherine M Munson, Gage H Garcia, Jordan Knuth, Julie Wertz, Tianyun Wang, Kelsey Hennick, Druha Karunakaran, Rafael A Polo Prieto, Rebecca Meyer-Schuman, Fisher Cherry, Davut Pehlivan, Bernhard Suter, Jonas A Gustafson, Danny E Miller, Human Pangenome Reference Consortium (Hprc), Hanna Berk-Rauch, Tomasz J Nowakowski, Aravinda Chakravarti, Huda Y Zoghbi, Evan E Eichler
Using The Linear References From The Pangenome To Discover Missing Autism Variants, Yang Sui, Jiadong Lin, Michelle D Noyes, Youngjun Kwon, Isaac Wong, Nidhi Koundinya, William T Harvey, Mei Wu, Kendra Hoekzema, Katherine M Munson, Gage H Garcia, Jordan Knuth, Julie Wertz, Tianyun Wang, Kelsey Hennick, Druha Karunakaran, Rafael A Polo Prieto, Rebecca Meyer-Schuman, Fisher Cherry, Davut Pehlivan, Bernhard Suter, Jonas A Gustafson, Danny E Miller, Human Pangenome Reference Consortium (Hprc), Hanna Berk-Rauch, Tomasz J Nowakowski, Aravinda Chakravarti, Huda Y Zoghbi, Evan E Eichler
Duncan NRI Faculty and Staff Publications
To better understand large-effect pathogenic variation associated with autism, we generated long-read sequencing (LRS) data to construct phased and near-complete genome assemblies (average contig N50 = 43 Mbp, QV = 56) for 189 individuals from 51 families with unsolved cases. We applied read- and assembly-based strategies to facilitate comprehensive characterization of de novo mutations, structural variants (SVs), and DNA methylation. Using LRS pangenome controls, we efficiently filtered >97% of common SVs exclusive to 87 offspring. We find no evidence of increased autosomal SV burden for probands when compared to unaffected siblings yet observe a suggestive trend toward an increased SV …
Gastrointestinal Histology Of Systemic Sclerosis: A Systematic Review, Aidan K Strother, Robert M Anderton, Naveen Kalavar, Ali Y Ayla, Tracy Ashby, Amanda Mayer, Roshan Dongre, Francesco Bonomi, Silvia Bellando Randone, Michael Hughes, Zsuzsanna H Mcmahan
Gastrointestinal Histology Of Systemic Sclerosis: A Systematic Review, Aidan K Strother, Robert M Anderton, Naveen Kalavar, Ali Y Ayla, Tracy Ashby, Amanda Mayer, Roshan Dongre, Francesco Bonomi, Silvia Bellando Randone, Michael Hughes, Zsuzsanna H Mcmahan
Library Staff Publications
Objective: To systematically review and synthesize the histological findings of gastrointestinal (GI) tissue in patients with systemic sclerosis (SSc), aiming to clarify the role of fibrosis and other pathological processes in SSc-related GI disease.
Methods: A comprehensive literature search was conducted across MEDLINE (OVID), Web of Science, and Cochrane Library databases for studies published in English from 1960 to 2025. Inclusion criteria required studies to report qualitative histological findings from GI tissue (esophagus to anorectum) in adult SSc patients, excluding those with overlapping autoimmune diseases or malignancy. Data extraction and appraisal were performed independently by multiple reviewers.
Results: Of 1697 …
2025 Highlights In Non-Invasive Neurostimulation And Neuromodulation For Headache Management, Chai Ching Ng, Hsiangkuo Yuan
2025 Highlights In Non-Invasive Neurostimulation And Neuromodulation For Headache Management, Chai Ching Ng, Hsiangkuo Yuan
Department of Jefferson Headache Center Papers and Presentations
No abstract available
Introducing "Visual Bibliographies" As A Novel Tool For Communicating Complexity: A Knowledge Translation Case Study From Aboriginal And Torres Strait Islander Primary Health Care Research, Kathleen P. Conte, Alison Laycock, Jodie Bailie, Veronica Matthews, Ross Bailie
Introducing "Visual Bibliographies" As A Novel Tool For Communicating Complexity: A Knowledge Translation Case Study From Aboriginal And Torres Strait Islander Primary Health Care Research, Kathleen P. Conte, Alison Laycock, Jodie Bailie, Veronica Matthews, Ross Bailie
Homelessness Research & Action Collaborative Publications and Presentations
Background
Effective knowledge translation ensures health care research has desired impacts – this is particularly important for Indigenous communities who have historically not benefited from research about and on them. Yet much knowledge translation in Indigenous contexts continues without community partnerships and disregards Indigenous values, languages and knowledge-sharing practices. Visual approaches can be engaging knowledge translation strategies that align with Indigenous knowledge translation traditions and amplify Indigenous perspectives. In this paper, we introduce a new tool we have coined a “Visual Bibliography” for knowledge generation and translation, developed within a large-scale, participatory research collaboration in Aboriginal and Torres Strait Islander …
Tead-Independent Mechanisms Of Yap Function In Cardiomyocyte Cell Cycle Reentry, Lin Liu, Chang-Ru Tsai, Todd R Heallen, Wyatt Paltzer, Yuka Morikawa, Fansen Meng, Jun Wang, James F Martin
Tead-Independent Mechanisms Of Yap Function In Cardiomyocyte Cell Cycle Reentry, Lin Liu, Chang-Ru Tsai, Todd R Heallen, Wyatt Paltzer, Yuka Morikawa, Fansen Meng, Jun Wang, James F Martin
Faculty, Staff and Students Publications
Adult mammalian hearts exhibit limited regenerative capacity because of the restricted renewal of cardiomyocytes. Recent studies reveal that mammalian hearts exhibit transient regenerative potential within a short time frame after birth, suggesting a regulatory mechanism that prevents adult hearts from initiating a regenerative response to cardiac injury. Here, we discovered that an active form of YAP, named YAP6SA, which is not inhibited by the Hippo signaling pathway and does not interact with TEADs, induces cardiomyocyte cell cycle reentry. In addition, YAP6SA interacts with scaffold protein MPDZ to regulate Rho GTPases and promote cell cycle progression in cardiomyocytes (CMs). Importantly, YAP6SA …
Intestinal Epithelial Tlr5 Signaling Promotes Barrier-Supportive Macrophages, Lisette Peres-Tintin, Dean B Matthews, Nikketa Stanford, Karuna Ganesh, Mary K Estes, Gretchen E Diehl
Intestinal Epithelial Tlr5 Signaling Promotes Barrier-Supportive Macrophages, Lisette Peres-Tintin, Dean B Matthews, Nikketa Stanford, Karuna Ganesh, Mary K Estes, Gretchen E Diehl
Faculty, Staff and Students Publications
Intestinal macrophages are essential for epithelial barrier repair. In homeostasis, macrophages are continuously replenished by recruitment of circulating CCR2+ monocytes into the intestinal lamina propria. This requires the commensal microbiota, however, the specific microbial factors and downstream host pathways that coordinate macrophage replenishment are inadequately understood. Here, we show that colonization with an E. coli isolate increased CCR2+ macrophages in the intestine and ameliorated pathology in a colitis model. Using human colonic organoids, we showed E. coli colonization induced CCL2 secretion by intestinal epithelial stem cells which promoted monocyte migration. In vivo, protection was abolished in the absence of epithelial …
De Novo Variants In The Splicing Factor Gene Sf3b1 Are Associated With Neurodevelopmental Disorders, Solène Chapalain, Camille Desdouets, Séverine Commet, Changlian Zhu, Yiran Xu, Yangong Wang, Tony Roscioli, Frederic Tran-Mau-Them, Laurence Faivre, Julien Maraval, Julian Delanne, Anne-Sophie Denommé-Pichon, Antonio Vitobello, Céline Jost, Marc Planes, Susan Hiatt, Patricia Wheeler, Claudia Gonzaga-Jauregui, Heng Wang, Baozhong Xin, Valerie Sency, Michael C Kruer, Somayeh Bakhtiari, Patrick Sulem, Cynthia Curry, Trine Prescott, Gertrud Strobl-Wildemann, Theresa Brunet, Martine Doco Fenzy, Thomas Courtin, Céline Poirsier, Trine Bjørg Hammer, Christina D Fenger, Melissa Macpherson, Kosuke Izumi, Jacqueline Leonard, Dong Li, Elaine H Zackai, Ian A Glass, Scott Ward, Philippe M Campeau, Maria Carla Hermida Borroto, Laurence Le Moigno, Hilde Van Esch, Liesbeth De Waele, Daniel G Calame, James R Lupski, Giulia Barcia, Cristina Peduto, Pauline Planté-Bordeneuve, Lucie Dupuis, Roberto Mendoza-Londono, Dimitri J Stavropoulos, Jennifer Gillibert-Duplantier, Thomas Besnard, Laura Do Souto Ferreira, Benjamin Cogné, Stéphane Bézieau, Arnaud Droit, Laurent Corcos, Eric Lippert, Claude Férec, Sebastien Küry, Delphine G Bernard
De Novo Variants In The Splicing Factor Gene Sf3b1 Are Associated With Neurodevelopmental Disorders, Solène Chapalain, Camille Desdouets, Séverine Commet, Changlian Zhu, Yiran Xu, Yangong Wang, Tony Roscioli, Frederic Tran-Mau-Them, Laurence Faivre, Julien Maraval, Julian Delanne, Anne-Sophie Denommé-Pichon, Antonio Vitobello, Céline Jost, Marc Planes, Susan Hiatt, Patricia Wheeler, Claudia Gonzaga-Jauregui, Heng Wang, Baozhong Xin, Valerie Sency, Michael C Kruer, Somayeh Bakhtiari, Patrick Sulem, Cynthia Curry, Trine Prescott, Gertrud Strobl-Wildemann, Theresa Brunet, Martine Doco Fenzy, Thomas Courtin, Céline Poirsier, Trine Bjørg Hammer, Christina D Fenger, Melissa Macpherson, Kosuke Izumi, Jacqueline Leonard, Dong Li, Elaine H Zackai, Ian A Glass, Scott Ward, Philippe M Campeau, Maria Carla Hermida Borroto, Laurence Le Moigno, Hilde Van Esch, Liesbeth De Waele, Daniel G Calame, James R Lupski, Giulia Barcia, Cristina Peduto, Pauline Planté-Bordeneuve, Lucie Dupuis, Roberto Mendoza-Londono, Dimitri J Stavropoulos, Jennifer Gillibert-Duplantier, Thomas Besnard, Laura Do Souto Ferreira, Benjamin Cogné, Stéphane Bézieau, Arnaud Droit, Laurent Corcos, Eric Lippert, Claude Férec, Sebastien Küry, Delphine G Bernard
Faculty, Staff and Students Publications
SF3B1 is an essential and ubiquitous splicing factor that plays a pivotal role in the early steps of pre-mRNA splicing. Recurrent somatic missense mutations in SF3B1 are frequent in cancers, but no constitutional variant has been reported so far. We describe here a cohort of 26 individuals with neurodevelopmental disorders, harbouring SF3B1 constitutional heterozygous variants that appeared mostly de novo. Patients present with a global developmental delay, associated with variable neurological and facial dysmorphic traits. A dichotomy may emerge between patients harbouring predicted loss of function (n = 9) and missense variants (n = 17), the latter being associated with …
Pediatric Acute Myeloid Leukemia Tumor Composition Predicts Patient Outcomes At Diagnosis And Reveals Mechanisms Of Resistance To Chemotherapy, Max Rochette, Sohani Sandhu, Lana Kim, Sridevi Addanki, Josh Cooper, Hua-Sheng Chiu, Jessica Epps, Sonal Somvanshi, Barry Zorman, Maria Rodriguez Martinez, Marianna Rapsomaniki, Susanne Unger, Burkhard Becher, Joanna S Yi, Tsz-Kwong Man, Michele L Redell, Pavel Sumazin
Pediatric Acute Myeloid Leukemia Tumor Composition Predicts Patient Outcomes At Diagnosis And Reveals Mechanisms Of Resistance To Chemotherapy, Max Rochette, Sohani Sandhu, Lana Kim, Sridevi Addanki, Josh Cooper, Hua-Sheng Chiu, Jessica Epps, Sonal Somvanshi, Barry Zorman, Maria Rodriguez Martinez, Marianna Rapsomaniki, Susanne Unger, Burkhard Becher, Joanna S Yi, Tsz-Kwong Man, Michele L Redell, Pavel Sumazin
Faculty, Staff and Students Publications
Although most pediatric acute myeloid leukemia (pAML) patients achieve complete remission with standard-of-care chemotherapy, overall outcomes are poor, and 40% will eventually relapse. Improved methods for risk assessment at diagnosis and alternative therapies are needed to improve outcomes for these patients. Toward these objectives, we characterized the clonal composition of pAMLs, identifying subclones that expand or transform between diagnosis and relapse. We further showed that the abundance of these expanding and transforming subclones in diagnostic samples is predictive of patient outcomes and, similarly, predicts response to chemotherapy and targeted therapies in patient samples and patient-derived xenograft models. Moreover, gene expression …
Hiv Vpr Induces Demethylation Of The Snca Antisense Promoter, Leading To Neurocognitive Impairment, Jin Park, Lynn G Kirby, Jeannie Chin, Jaroslav Jelinek, Natalia Shcherbik, Bassel E Sawaya
Hiv Vpr Induces Demethylation Of The Snca Antisense Promoter, Leading To Neurocognitive Impairment, Jin Park, Lynn G Kirby, Jeannie Chin, Jaroslav Jelinek, Natalia Shcherbik, Bassel E Sawaya
Faculty, Staff and Students Publications
Human immunodeficiency virus type 1 (HIV-1) alpha-synuclein (α-Syn) aggregation is a hallmark of neurodegenerative diseases. Accumulation and aggregation of α-Syn are often observed in individuals with HIV-1 cognitive impairments. The direct mechanistic link between α-Syn dysregulation and HIV-associated neurocognitive disorders (HAND) remains unclear. Emerging evidence suggests that epigenetic changes, particularly deoxyribonucleic acid (DNA) demethylation, influence α-Syn regulation. We show that the HIV-1 protein viral protein R (Vpr) demethylates the antisense promoter within intron 1 of the alpha-synuclein gene (SNCA), potentially contributing to increased α-Syn expression. Elevated α-Syn promotes aggregation, causing synaptic dysfunction and impaired mitochondrial transport. These processes contribute to …
Fyn-Saracatinib Complex Structure Reveals An Active State-Like Conformation, Josephine C Ferreon, Allan Chris M Ferreon, Choel Kim
Fyn-Saracatinib Complex Structure Reveals An Active State-Like Conformation, Josephine C Ferreon, Allan Chris M Ferreon, Choel Kim
Faculty, Staff and Students Publications
Fyn is a Src-family tyrosine kinase implicated in synaptic dysfunction and neuroinflammation across multiple neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Saracatinib (AZD0530) is a potent Src-family inhibitor that has been explored as a repurposed therapeutic; however, its clinical utility is limited by poor kinase selectivity caused by high sequence conservation within Src-family ATP-binding sites. Here, we combine surface plasmon resonance (SPR) and X-ray crystallography to define saracatinib recognition by the Fyn kinase domain (KD). SPR single-cycle kinetics shows that saracatinib binds the isolated Fyn KD and full-length Fyn with low-nanomolar affinity, whereas dasatinib binds with subnanomolar …
Saga/Atac Complexes Sustain Aberrant Chromatin Regulation And Promote Tumorigenesis In Diffuse Midline Glioma, Brittany R Eberl, Alan L Jiao, Adam F Kebede, Barry M Zee, Margaret M Harrington, Mariella G Filbin, Akdes Serin-Harmanci, Yang Shi, Jamie N Anastas
Saga/Atac Complexes Sustain Aberrant Chromatin Regulation And Promote Tumorigenesis In Diffuse Midline Glioma, Brittany R Eberl, Alan L Jiao, Adam F Kebede, Barry M Zee, Margaret M Harrington, Mariella G Filbin, Akdes Serin-Harmanci, Yang Shi, Jamie N Anastas
Faculty, Staff and Students Publications
Diffuse midline gliomas (DMG) are aggressive pediatric brain tumors characterized by chromatin and transcriptional dysregulation induced by H3K27M mutations. Strategies for overcoming epigenetic dysfunction to reduce DMG tumorigenesis remain limited. We identified multiple components of the SAGA and ATAC chromatin regulatory complexes as DMG genetic dependencies and found that genetic or pharmacological inhibition of the SAGA/ATAC-associated chromatin reader SGF29 reduces DMG proliferation. Small molecules targeting SAGA/ATAC-associated histone acetylation, ubiquitination, and methylation similarly suppressed DMG growth. Further chromatin profiling and RNAseq analyses reveal that SGF29 controls H3K9ac and H3K4me3 dynamics at both H3K27M-bound and H3K27M-independent target genes linked to proliferation, differentiation, …
Multilevel Analysis Of The Food And Physical Activity Environment And Adult Obesity Across U.S. Counties And States
Faculty, Staff and Student Publications
Adult obesity rates have risen steadily across the United States over the past decade, with more than 40% of adults affected. Persistent geographic and demographic disparities exist in obesity prevalence across the nation. While prior research has examined individual or environmental associated factors of obesity, limited studies have addressed both physical activity and food environments across the nation using multilevel approaches. This cross-sectional ecological study (2014-2024) used a two-level random intercept model to assess the association between county- and state-level factors and adult obesity prevalence across over 3000 U.S. counties nested within 51 states. County-level associated factors included food insecurity, …
Tumor Cell Clustering Enhances Metastatic Competence By Regulating The H3k36 Histone Demethylase Kdm2a, Dejian Zhao, Tang Tang, Sampada Chande, Minghui Zhao, Yuchen Huo, Thomas F Westbrook, Qin Yan, Don X Nguyen
Tumor Cell Clustering Enhances Metastatic Competence By Regulating The H3k36 Histone Demethylase Kdm2a, Dejian Zhao, Tang Tang, Sampada Chande, Minghui Zhao, Yuchen Huo, Thomas F Westbrook, Qin Yan, Don X Nguyen
Faculty, Staff and Students Publications
Disseminated tumor cells can form clusters via cell-cell adhesion, which increases their capacity to initiate metastasis. Metastatic clusters are characterized by distinct changes in transcription, suggesting that epigenetic mechanisms underlie their unique phenotypic state. By performing functional epigenomic studies in models of non-small cell lung cancer, we identified the histone H3 lysine 36 (H3K36) demethylase KDM2A as being differentially required for the fitness of metastatic cell clusters. This contextual dependency on KDM2A is predicated by tumor cell-cell aggregation, which specifically induces KDM2A binding to CpG island enriched promoters. At these defined genomic loci, KDM2A maintains H3K36 monomethylation, which preferentially correlates …
Community And Individual Risk Factors Associated With Tuberculosis Treatment Outcomes: Ca, Md, And Oh, [2017-2021]., Kadiatu Banjoko
Community And Individual Risk Factors Associated With Tuberculosis Treatment Outcomes: Ca, Md, And Oh, [2017-2021]., Kadiatu Banjoko
Walden Dissertations and Doctoral Studies
There are unsuccessful treatment outcomes with Tuberculosis (TB) disease, although effective therapies exist. This study aimed to identify predictors of unsuccessful treatment using the socioecological model. A quantitative cross-sectional study and multinomial logistic regression analysis were used to measure the associations between long-term care (LTC), homelessness, correctional facility, Human Immunodeficiency Virus (HIV), diabetes, excess alcohol, illicit drug use, and TB treatment outcomes of death, lost to follow-up, and treatment refusal. The sample consisted of 7,589 individuals aged 15 and older with pulmonary TB between 2017 and 2021, residing in California, Ohio, and Maryland. Findings indicated a correlation between community factors …
Analisis Usia Awal Merokok Remaja Dan Perilaku Merokok Orang Tua Di Indonesia: Studi Gshs 2015, Cathrine Jane David, Qonita Ayunina, Janitra Larasati, Glory Soemoele
Analisis Usia Awal Merokok Remaja Dan Perilaku Merokok Orang Tua Di Indonesia: Studi Gshs 2015, Cathrine Jane David, Qonita Ayunina, Janitra Larasati, Glory Soemoele
Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan
Kebiasaan merokok masih menjadi permasalahan kesehatan global, termasuk Indonesia. Tingginya prevalensi perokok usia remaja menjadi tantangan kesehatan masyarakat yang salah satu penyebabnya adalah perilaku merokok orang tua. Oleh karena itu, penelitian ini bertujuan untuk menganalisa hubungan antara perilaku merokok orang tua dengan usia awal merokok pada remaja. Penelitian ini menggunakan desain studi potong lintang berdasarkan data Global School-based Student Health Survey (GSHS) 2015. Sampel penelitian ini berjumlah 2027 responden yang dipilih secara acak sistematik. Analisis data dilakukan dengan analisis univariat dan bivariat menggunakan uji Chi-square untuk melihat hubungan antar variabel. Hasil analisis menunjukkan bahwa sebagian besar responden memulai kebiasaan merokok …
Analisis Klaim Odc Dan Kesiapan Sistem Informasi Rumah Sakit Dalam Mendukung Pengelolaan Klaim Bpjs: Studi Kasus Di Rs. Fatmawati, Grahyta Dhamayanti, Arifin Arifin
Analisis Klaim Odc Dan Kesiapan Sistem Informasi Rumah Sakit Dalam Mendukung Pengelolaan Klaim Bpjs: Studi Kasus Di Rs. Fatmawati, Grahyta Dhamayanti, Arifin Arifin
Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan
Masalah klaim tertunda BPJS Kesehatan pada layanan rawat inap kategori one day care (ODC) masih menjadi isu strategis di Rumah Sakit (RS) Fatmawati. Hal ini menyebabkan layanan tidak efisien dan potensi kerugian finansial. Hingga saat ini, mekanisme deteksi dini yang sistematis untuk mengidentifikasi masalah potensi klaim ODC belum tersedia secara optimal. Penelitian ini bertujuan menganalisis pola klaim ODC serta menyusun model konseptual deteksi dini potensi klaim ODC berbasis data Sistem Informasi Manajemen Rumah Sakit (SIMRS). Penelitian menggunakan desain deskriptif analitik dengan pendekatan metode campuran. Analisis kuantitatif dilakukan terhadap 2.401 data klaim rawat inap periode Januari–April 2025 di RS. Fatmawati, meliputi …
When Textbook Meets Reality: A Rare Case Of Boerhaave’S Syndrome With Mackler’S Triad, Taiwo Ajani, Jose J. Loayza Pintado, Nayiri Derian, Andres Suarez-Parraga, Ernesto Garza
When Textbook Meets Reality: A Rare Case Of Boerhaave’S Syndrome With Mackler’S Triad, Taiwo Ajani, Jose J. Loayza Pintado, Nayiri Derian, Andres Suarez-Parraga, Ernesto Garza
School of Medicine Publications
Boerhaave’s syndrome is a rare and life-threatening form of spontaneous esophageal perforation, typically triggered by forceful vomiting and often misdiagnosed due to nonspecific clinical features. Although Mackler’s triad (vomiting, chest pain, and subcutaneous emphysema) is classically associated with the condition, it is infrequently observed in full. We present the case of a 32-year-old man with a history of ulcerative colitis (UC) who presented to the emergency department with acute chest pain and repeated vomiting following dinner. He reported a sensation of food impaction and sought care 2 hours after symptom onset. Examination revealed subcutaneous emphysema and abdominal tenderness. Imaging with …
Creative Arts To Enhance Cervical Cancer Awareness Using Art-Based Messages From A Nigerian Crowdsourcing Open Call: Qualitative Thematic Analysis, Abdulhammed O Babatunde, Olufunto A Olusanya, Peter Kalulu, Temitope Ojo, Onyekachukwu Anikamadu, Juliet Iwelunmor, Et Al.
Creative Arts To Enhance Cervical Cancer Awareness Using Art-Based Messages From A Nigerian Crowdsourcing Open Call: Qualitative Thematic Analysis, Abdulhammed O Babatunde, Olufunto A Olusanya, Peter Kalulu, Temitope Ojo, Onyekachukwu Anikamadu, Juliet Iwelunmor, Et Al.
2020-Current year OA Pubs
BACKGROUND: Cervical cancer is a leading cause of cancer deaths among women in Nigeria, yet awareness is low. Historically, art has served as a medium for processing emotions and sharing experiences, which can be effective in promoting health and behavior change.
OBJECTIVE: This study aimed to examine art submissions and social media engagement from a Nigerian crowdsourcing open call to inform co-designed strategies for cervical cancer prevention among women.
METHODS: This study reported following the SRQR (Standard Reporting for Qualitative Research) guideline. From October to November 2023, we launched an open call for art on social media, inviting adult women …
Two Axes Of White Matter Development, Audrey C Luo, Deanna M Barch, Et Al.
Two Axes Of White Matter Development, Audrey C Luo, Deanna M Barch, Et Al.
2020-Current year OA Pubs
Despite decades of neuroimaging research, how white matter develops along the length of major tracts in humans remains unknown. Here, we identify fundamental patterns of white matter maturation by examining developmental variation along major, long-range cortico-cortical tracts in youth ages 5-23 years using diffusion MRI from three large-scale, cross-sectional datasets (total N = 2716). Across datasets, we delineate two replicable axes of human white matter development. First, we find a deep-to-superficial axis, in which superficial tract regions near the cortical surface exhibit greater age-related change than deep tract regions. Second, we demonstrate that the development of superficial tract regions aligns …
Clinical Workflow Of Spine Stereotactic Radiotherapy And Radiosurgery: Insights From A Single-Institution Physics Perspective, Dennis Mackin, Gizem Cifter, Yana Zlateva, Jihong Wang, Yao Ding, Zhiheng Wang, Fada Guan, Travis C Salzillo, Shane Krafft, Jing Li, Martin C Tom, Amol J Ghia, Tina Marie Briere
Clinical Workflow Of Spine Stereotactic Radiotherapy And Radiosurgery: Insights From A Single-Institution Physics Perspective, Dennis Mackin, Gizem Cifter, Yana Zlateva, Jihong Wang, Yao Ding, Zhiheng Wang, Fada Guan, Travis C Salzillo, Shane Krafft, Jing Li, Martin C Tom, Amol J Ghia, Tina Marie Briere
Faculty, Staff and Student Publications
Spine stereotactic radiotherapy and radiosurgery (SSRS) techniques, encompassing both fractionated stereotactic treatments and single-fraction radiosurgery, are widely used for the management of spinal metastases due to their ability to deliver highly conformal radiation while limiting dose to adjacent critical structures. Clinical outcomes following SSRS, including durable local control and acceptable toxicity, have been reported previously in multiple institutional series. In this manuscript, we describe the clinical workflow used to deliver SSRS at a high-volume academic center, with emphasis on the medical physics processes that support routine clinical practice. Key elements of the workflow include patient selection, treatment region-specific immobilization, CT …
Writing Professional Papers Worksheet With Scavenger Hunt: A Simple Strategy To Strengthen Dietetic Writing, Stacy Bevan
Writing Professional Papers Worksheet With Scavenger Hunt: A Simple Strategy To Strengthen Dietetic Writing, Stacy Bevan
Journal of Dietetic Education
Time between learning scientific writing skills and when dietetic students need to transfer that knowledge to discipline-specific research papers in upper division courses may result in a lack of writing skills. Dietetic educators be unfamiliar with writing strategies to improve student writing. A Writing Professional Papers worksheet was developed to help students define components of professional papers, draft a thesis, and then participate in a scavenger hunt using examples of two types of professional papers to identify target issues and avoid common issues seen in student papers. Students in an upper division Maternal and Child Nutrition course responded to an …
Public Policy Education: Insights From Graduate Dietetics Students, J. Mitchell Vaterlaus, Lindsay Ganong, D. Coleen Kaiser, Emily Patten
Public Policy Education: Insights From Graduate Dietetics Students, J. Mitchell Vaterlaus, Lindsay Ganong, D. Coleen Kaiser, Emily Patten
Journal of Dietetic Education
Objective: To examine graduate dietetics students’ experiences completing a public policy course outside of their discipline. Methods: Participants were 40 graduate dietetics students at a university in the Western United States. At the conclusion of a public policy course offered through another department, students completed online surveys with fixed-response and open-ended items. Quantitative data were analyzed using paired t tests, and qualitative responses were examined using codebook thematic analysis. Results: Three themes included (1) Recognizing the interconnection between policy and dietetics practice, (2) From policy hesitancy to policy understanding; and (3) Humanizing policy: public policy and holistic client care. Students …