Medicine and Health Sciences Commons^™

Pengaruh Penggunaan Asam Sulfat (H2so4) Dan Asam Formiat (Hcooh) Pada Proses Pikel Terhadap Kualitas Kulit Jadi (Leather) Domba Garut (The Effect Of Sulfuric Acid (H2so4) And Formic Acid (Hcooh) In Pickle Process On Garut Sheep Leather Quality), Jajang Gumilar, Wendry Setiyadi Putranto, Eka Wulandari

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan berbagai tingkat asam sulfat (H2So4) dan asam formiat (HCOOH) pada proses pikel  terhadap kualitas kulit jadi (leather) Domba Garut. Kualitas Kulit jadi didasarkan pada kadar keasaman (pH), kadar krom (Cr2O3), dan kadar air (H2O). Penelitian ini dilakukan secara eksperimen menggunakan pola faktorial dengan rancangan dasar rancangan acak lengkap, menggunakan 48 lembar kulit Domba Garut jantan ukuran 90. Kulit-kulit tersebut dibagi kedalam 16 kelompok. Tiap-tiap kelompok diberikan perlakuan penggunaan asam sulfat dan asam formiat. Masing-masing kelompok diulang sebanyak 3 kali ulangan. Hasil penelitian ini menunjukkan bahwa penggunaan berbagai tingkat asam sulfat (H2So4) dan asam …

Pengaruh Suplemen Zn-Proteinat, Cu-Proteinat Dan Kompleks Ca-Minyak Ikan Dalam Ransum Berbasis Pucuk Tebu Amoniasi Terhadap Performans Domba Jantan Persilangan Priangan X Barbados, U. Hidayat Tanuwiria, Budi Ayuningsih

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan mempelajari pengaruh suplemen Zn-Proteinat, Cu-Proteinat dan Ca-Minyak dalam ransum berbasis pucuk tebu diamoniasi terhadap pertumbuhan dan efisiensi ransum pada domba jantan persilangan Priangan x Barbados. Percobaan dilakukan terhadap 5 ekor domba jantan yang sedang tumbuh dengan menggunakan rancangan Bujur Sangkar Latin (BSL) 5x5,  lima macam ransum yaitu R1 = campuran 50% pucuk tebu amoniasi + 50% konsentrat, R2 = R1 + 2% Zn-proteinat, R3 = R1 + 2% Cu-proteinat, R4 = R2 + 2% Cu-proteinat, dan R5 = R4 + Ca-minyak ikan. Hasil yang diperoleh menunjukkan bahwa pemberian Zn-proteinat, Cu-proteinat dan komplek  Ca-minyak tidak mempengaruhi konsumsi ransum, …

Prospective Comparison Of Wbc Spect/Ct And Conventional Mri For Diagnosing Osteomyelitis And Monitoring Treatment Response In Diabetic Foot Infections, Orhan Oz, Amber M. Sherwood, Peter A. Crisologo, Amanda L. Killeen, Kavita Bhavan, Javier La Fontaine, Katie L. Rubitschung, Helena Hwang, Robert W. Haley, Lawrence A. Lavery

School of Podiatric Medicine Publications

Aims/hypothesis: Osteomyelitis is a common complication of diabetic foot ulcers and a leading cause of lower limb amputations globally. Accurate diagnosis of diabetic foot osteomyelitis (DFO) is essential for effective infection management and improving prognosis. This study aimed to compare the performance of white blood cell (WBC)-single photon emission computed tomography (SPECT)/computed tomography (CT) and conventional MRI in the initial diagnosis of DFO and in detecting residual infection during treatment monitoring, using bone biopsy as the reference standard.

Methods: In this prospective clinical study, 47 patients with foot wounds suspicious for DFO underwent 99mTc-WBC SPECT/CT and MRI, followed by bone …

Pesticides Associated With Incident Diabetes Among Licensed Private Pesticide Applicators In The Agricultural Health Study Cohort (1993–2021), Christine G Parks, Qian Xiao, Jesse Wilkerson, Jonathan N Hofmann, Laura E Beane Freeman, Dale P Sandler

Faculty, Staff and Student Publications

Background: Growing evidence suggests pesticides may increase risk of type 2 diabetes, but data are limited on many specific chemicals.

Methods: In 29,527 private pesticide applicators in the Agricultural Health Study cohort (enrolled 1993-1997 in Iowa and North Carolina), 3,847 incident diabetes cases were identified by self-report during follow-up surveys in 1999-2003, 2005-2010, 2013-2015, and 2019-2021. We examined 50 pesticides reported at enrollment, updated in 1999-2003 or 2005-2010, prior to diabetes diagnosis or end of follow-up, using log-binomial regression to calculate relative risks (RR) and 95% confidence intervals (CI) for ever-use and intensity-weighted lifetime days (IWLD) use (tertiles, T1-3), adjusting …

Potensi Pakan Serat Dan Daya Dukungnya Terhadap Populasi Ternak Ruminansia Di Wilayah Kabupaten Garut, U. Hidayat Tanuwiria, A. Yulianti, A. Mushawwir

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan untuk mempelajari potensi pakan asal limbah tanaman pangan dan daya dukungnya terhadap populasi ternak ruminansia di wilayah kabupaten Garut. Penelitian dilakukan dengan cara survey dan pengumpulan data sekunder.  Hasil penelitian menunjukkan bahwa Potensi pakan asal rumput alam dan jerami asal limbah tanaman pangan di seluruh wilayah kabupaten Garut adalah 414.211,1 ton bahan kering (BK) yang terdiri atas 151.395,6 ton BK asal rumput dan 262.815,5 ton BK asal limbah tanaman pangan. Daya dukung pakan terhadap populasi ternak adalah 124.706 satuan ternak (ST), yang terdiri atas 45.580,5 ST ternak ruminansia kecil dan 79.125,5 ST ternak ruminansia besar.

Kata Kunci …

Potensi Pakan Asal Limbah Tanaman Pangan Dan Daya Dukungnya Terhadap Populasi Ternak Ruminansia Di Wilayah Sumedang (Agriculture By Product As Potential Feed And Its Carrying Capacity In Sumedang), U. Hidayat Tanuwiria, N. Mayasari, A. Yulianti

Jurnal Ilmu Ternak Universitas Padjadjaran

Penelitian ini bertujuan untuk mempelajari potensi pakan asal limbah tanaman pangan dan daya dukungnya terhadap populasi ternak ruminansia di wilayah kabupaten Sumedang. Penelitian dilakukan dengan cara survey dan pengumpulan data sekunder.  Hasil penelitian menunjukkan bahwa Potensi pakan asal rumput alam dan jerami asal limbah tanaman pangan di seluruh wilayah kabupaten Sumedang adalah 284.784,72 ton bahan kering (BK) yang terdiri atas 86.937,65 ton BK asal rumput dan 197.847,07 ton BK asal limbah tanaman pangan. Daya dukung pakan terhadap populasi ternak adalah 85.739,79 satuan ternak (ST), yang terdiri atas 26.174,21 ST ternak ruminansia kecil dan 59.565,58 ST ternak ruminansia besar. Potensi protein …

Pemanfaatan Gelatin Tepung Sagu (Metroxylon Sago) Sebagai Bahan Pakan Ternak Ruminansia (Utilization Of Sago (Metroxylon Sago) Gelatin As Feed Ruminant), Harry Triely Uhi

Jurnal Ilmu Ternak Universitas Padjadjaran

Telah dilakukan penelitian pemanfaatan gelatin sagu sebagai bahan pakan ternak ruminansia. Tujuan penelitian untuk mengetahui suhu, waktu dan ratio volume air yang tepat selama pemanasan sampai terbentuknya gelatinisasi. Justifikasi terjadinya proses gelatinisasi didasarkan atas rusaknya bentuk granula yang dilihat dengan  mikroskop elektron dan mikroskop polarisasi. Perlakuan yang digunakan R1 (Tepung sagu 100 gram + suhu   80 ⁰C); R2 (Tepung sagu 100 gram + suhu   85 ⁰C); R3 (Tepung sagu 100 gram + suhu   90 ⁰C); R4 (Tepung sagu 100 gram + suhu   95 ⁰C); dan R5 (Tepung sagu 100 gram + suhu 100 ⁰C). Parameter …

Pengaruh Tepung Cangkang Rajungan (Portunus Pelagicus) Sebagai Sumber Kitin Dalam Ransum Terhadap Kandungan Lemak Feses Dan Efisiensi Pakan Tikus Putih (Rattus Norvegiccus) Strain Wistar (The Effect Of Crabs Shells (Portunus Pelagicus) As A Source Of Chi, Muhamad Fatah Wiyatna, Irba U. Warsono, Aminuddin Parakkasi

Jurnal Ilmu Ternak Universitas Padjadjaran

Cangkang rajungan mengandung kitin yang persentasenya paling besar berupa polisakarida. Kitin dan derivat-derivatnya telah banyak digunakan dalam berbagai keperluan terutama untuk kesehatan. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh pemberian tepung rajungan sebagai sumber kitin terhadap efisiensi pakan dan kandungan lemak feces tikus putih Rattus norvegicus) strain Wistar. Penelitian menggunakan rancangan acak lengkap pola faktorial 2x5 dengan tiga kali ulangan. Faktor pertama adalah jenis kelamin dan kedua level tepung rajungan yaitu 0%, 5%, 10%, 15%, and 20%. Hasilnya penelitian menunjukkan tidak ada interaksi antara jenis kelamin dengan kandungan teung rajungan dalam ransum. Kandungan lemak dalam feces tertinggi diperoleh …

Pengaruh Lama Penyimpanan Semen Cair Ayam Buras Pada Suhu 5 0c Terhadap Periode Fertil Dan Fertilitas Sperma (The Storage Time Effect Of The Local Chicken Chilled Semen At 5 0c On Fertility And Fertile Period Of Sperm), Nurcholidah Solihati, Ruhijat Idi, Rangga Setiawan, I.Y. Asmara

Jurnal Ilmu Ternak Universitas Padjadjaran

Tujuan penelitian ini untuk mengetahui sejauh mana pengaruh lama penyimpanan semen cair ayam buras pada suhu 5⁰C terhadap periode fertil dan fertilitas sperma.  Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan setiap perlakuan diulang 6 kali.  Lama penyimpanan yang digunakan dalam penelitian ini adalah penyimpanan 1 jam (0 hari), 24 jam (1 hari) dan 48 jam (2 hari).  Peubah yang diukur adalah periode fertil dan fertilitas sperma. Data yang diperoleh dianalisis dengan analisis sidik ragam, dan untuk mengetahui perbedaan antar perlakuan diuji dengan menggunakan uji jarak berganda Duncan. Hasil penelitian menunjukan bahwa lama penyimpanan semen …

Dietary Nitrate Supplementation Worsens Resistance Exercise Performance In Resistance-Trained Females, Sydney N. Brennan, Raymond T. Gerardo, Trevor J. Molnar, Justin M. Foster, Ryan Tran, Kyle S. Geppert, Christopher B. Sottile, Michael Egiazarian, Abigail F. Ballhagen, Stewart D. Gonzalez, Adam Pennell, Rachel Tan

International Journal of Exercise Science: Conference Proceedings

Dietary nitrate supplementation appears to preferentially target type II muscle fibers for beneficial effects; however, research examining the efficacy of nitrate in females and resistance exercise is scarce. PURPOSE: To investigate if dietary nitrate, provided as concentrated nitrate-rich beetroot juice (BR), improved resistance exercise performance in back squat and bench press compared to nitrate-depleted beetroot juice (PL) in resistance-trained females. METHODS: Eighteen resistance-trained females aged reported to the lab for a total of four visits over a 2-week period. Participants performed a one repetition maximum protocol (1RM) and familiarization to the experimental protocol, and were assigned in a randomized, double-blind …

Glycemic Control After Meals On People With Type 2 Diabetes And Prediabetes Following Resistance Exercise, Isaac Chapman, Kosar Valaei, Oscar Chavez, Marissa Ramirez, Jacob Dawes, Maja Gebauer, Christine M. Mermier, Jonathan Little, Luotao Lin, Gretchen M. Ray, Roberto Mota Alvidrez, Zachary A. Mang, Fabiano Amorim, Valmor Tricoli, Flavio De Castro Magalhaes

International Journal of Exercise Science: Conference Proceedings

Resistance exercise (RE) has been shown to improve glycemic control after a meal in type 2 diabetes (T2D) and prediabetes under controlled laboratory settings. PURPOSE: To investigate the effects of RE on glycemic control in a free-living environment. METHODS: This was a 4-arm randomized crossover study involving 22 participants with T2D (n=12) or prediabetes (n=10). Glucose was monitored using a continuous glucose monitoring device through the experimental situations that involved three separate exercise sessions: a high-intensity RE session (3 sets x 8 reps, 75%-1RM, 120 sec interval), a rest-redistribution RE session (6 sets x 4 reps, 75%-1RM, 60 sec interval), …

Body Composition Of Older Active Adults: The Huntsman Senior Games Study, Abby M. Hansen, Dale R. Wagner Facsm, Heather Feeny, Paxton Catillon, Alyssa Mcnutt, Elizabeth Cafferty, Ben Taylor, Matthew Densley, Nicolas Clark, Andrew Creer

International Journal of Exercise Science: Conference Proceedings

Body composition variables are important when it comes to studying athletic performance. With an aging population, being actively engaged in athletic competition in one’s “golden years” is more common than in previous generations. However, there is a lack of normative data for senior athletes relative to their younger counterparts. PURPOSE: The purpose of this study was to analyze the correlation between age and both body fat percentage (%BF) and fat-free mass index (FFMI) in senior athletes and classify the percentile ranks of these body composition variables. METHODS: Data were collected using an InBody 770 Multi-Frequency Bioelectrical Impedance Analysis machine. Data …

Effects Of Hypobaric Hypoxia During Intermittent Cycling Bouts On Markers Of Acute Kidney Injury, Jacob D. Dawes, Alyssa R. Bailly, Jonathan W. Specht, Christopher B. Hart, Mateo Griego, Marissa Ramirez, Kaia G. Allen, Alexander Smaragdas, Fabiano T. Amorim

International Journal of Exercise Science: Conference Proceedings

Many individuals travel to high altitudes for recreational or occupational purposes. Hypobaric hypoxia (HH) at altitude decreases arterial oxygen saturation (SaO₂), reduces oxygen delivery to tissues, and can adversely affect organ function. Exercise, independent of HH, significantly decreases renal blood flow (RBF). Therefore, performing exercise in HH may further impair oxygen delivery and place additional strain on the kidneys. While the impact of chronic HH on kidneys has been documented, there is limited research on the risk of acute kidney injury (AKI) under these conditions. PURPOSE: To investigate the effects of acute HH exposure during intermittent exercise …

Can Passive Water Immersion Shape Force Production Capacity?, Joonsun Park, Talin Louder

International Journal of Exercise Science: Conference Proceedings

Previous studies have shown mechanistic neurophysiological evidence to foster motor cortical and plasticity alongside improved cerebral perfusion. Although evidence remains limited, these neural effects suggest passive immersion may enhance force output capacity. PURPOSE: This study aimed to investigate the acute effects of passive water immersion in a seated position on lower-extremity isometric strength as measured by isometric mid-thigh pull (IMTP) performance on land. METHODS: Thirty-three active young adults (age: 22.64 ± 4.18 years, height: 174.55 ± 10.28 cm, mass: 81.45 ± 18.77 kg) completed both land and water conditions (LC and WC), with pre- and post-tests using within …

Effect Of Previous Night Alcohol On Thermoregulatory And Physiological Strain During Prolonged Physical Work In The Heat, Marissa Ramirez, Jonathan W. Specht, Flavio De Castro Magalhaes, Fabiano Amorim, Whitley C. Atkins

International Journal of Exercise Science: Conference Proceedings

Many occupational workers engage in strenuous physical work in hot environments for prolonged periods, placing them at risk of heat-related illness due to increasing physiological strain identified by increasing core temperature (Tcore) and heart rate (HR). Lifestyle behaviors, such as smoking, caffeine and alcohol consumption, and sleep deprivation, may further exacerbate heat strain and increase susceptibility to heat-related illness. Notably, alcohol consumption the night before work, and the subsequent hangover, may amplify physiological strain by impairing heat dissipation. However, no previous studies have evaluated the impact of alcohol hangover on heat strain during physical work in the heat. PURPOSE: …

Evaluating The Accuracy Of Sex-Dependent Algorithms In Commercial Wrist-Worn Wearables For Exercise Energy Expenditure, Olivia R. Perez, Dustin W. Davis, Michael W. H. Wong, James W. Navalta Facsm

International Journal of Exercise Science: Conference Proceedings

Commercial wrist-worn wearable devices are popular among sports and health enthusiasts. Energy expenditure (EE) is a valuable measurement returned from these devices, but the accuracy is variable. A gap exists in sport and exercise science concerning sex-specific accuracy and input algorithms. Purpose: This study aimed to evaluate the sex-specific validity of five commercial wrist-worn wearable devices in estimating exercise EE, with indirect calorimetry as the criterion. Methods: 97 adult participants were outfitted with two devices (n = 20 per device), one set to the "female" sex option on the right wrist and the other set to the "male" sex …

Sex-Specific Changes In Pbmc Mitochondrial Respiration Following Acute Exercise, Ryan R. Moon

International Journal of Exercise Science: Conference Proceedings

Exercise-trained individuals exhibit greater immune system function, which may be attributed in part to enhanced peripheral blood mononuclear cell (PBMC) function. Exercise training is a potent stimulator of mitochondrial adaptation, which may help explain improvements in immunity. However, the mechanisms by which exercise acutely modulates PBMCs to promote beneficial adaptations remain unclear. Purpose: The purpose of this study was to test the hypothesis that a single bout of aerobic exercise modulates PBMC mitochondrial function. Methods: Twenty-eight healthy young adults (13 females, 15 males; age 21.84 ± 2.78 years) completed a graded exercise test (VO₂max: 41.4 ± 7.64 ml O₂·kg⁻¹·min⁻¹) followed …

The Association Between Muscular Strength And C-Reactive Protein Among Post-Menopausal Women: Effect Modification By Hormone Replacement Therapy, Sarah Krager, Bethany Barone-Gibbs, Amanda Paluch, Samantha Ehrlich, Amy Miller, William Boyer

International Journal of Exercise Science: Conference Proceedings

Previous studies suggest that the inflammatory marker C-reactive protein (CRP) may be elevated in post-menopausal women taking hormone replacement therapy (HRT). Muscular strength is associated with more favorable CRP profiles. However, this association has not been examined among post-menopausal women on HRT. PURPOSE: This study aims to examine the association of lower leg strength and CRP while considering potential effect modification by HRT using a representative sample of U.S. adults. METHODS: The final sample (n=1,238) included post-menopausal women (≥50 years) who participated in the 1999-2002 National Health and Examination Survey (NHANES). CRP was examined continuously and categorically (/dl vs 3-10 …

Possible Intervertebral Disc Disease Related To Ventricular Tachycardia In A Labrador Retriever, Nadthagarn Glaewketgarn, Sirilak Disatian Surachetpong

The Thai Journal of Veterinary Medicine

Ventricular arrhythmia (VA) is a common arrhythmia in dogs. Several extracardiac causes such as pain may contribute this condition. This case report describes a 9-year-old neutered male Labrador Retriever with ventricular tachycardia (VT) potentially related to severe neck pain due to intervertebral disc disease (IVDD). The dog was referred with a sign of inability to walk, tachypnea and an irregular heartbeat. Electrocardiography confirmed VT at 160-200 bpm and an increased cardiac troponin I level (35.22 ng/ml). Despite antiarrhythmic treatment, the VT persisted. Cardiac evaluation revealed no structural abnormalities. Interestingly, VT episodes were provoked by cervical palpation and resolved following analgesic …

Plasma Proteomic Profiling Reveals Distinct Protein Signatures Associated With Hepatocellular Carcinoma In Chronic Hepatitis B Infection, Sidnooma Véronique Zongo, Michael A. Bauer, Lassina Traore, Tegwinde Rebeca Compaore, Albert Théophane Yonli, Augustin Tozoula Bambara, Palwendé Romuald Boua, Roger Arsène Sombié, Oumar Barro, Sosthene K. Somda, Mahamoudou Sanou, Jeremy James Martinson, Jean Christopher Chamcheu, Lewis R. Roberts, Mitesh J Borad, Bolni Marius Nagalo, Alan J Tackett, Adama Sanou, Florencia Wendkuuni Djigma, Jacques Simpore

Faculty Publications

Background

Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), yet reliable biomarkers for early detection and risk stratification remain limited. This study aimed to identify plasma proteins associated with disease progression from chronic HBV infection to HCC.

Methods

Plasma proteomic profiling was conducted using high-resolution LC–MS/MS on samples from healthy controls, chronic HBV carriers, patients with cirrhosis, and individuals with HBV-associated HCC. Differentially expressed proteins were identified through bioinformatics analysis, and protein–protein interaction networks were reconstructed to assess functional relevance.

Results

Eight proteins displayed distinct, stage-specific expression patterns along the disease continuum. ICAM1, TIMP1, …

Host-Derived Interleukin-1Α Drives Tumor Immunosuppression By Reprogramming Tumor-Associated Myeloid Cells, Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson, Katie Kathrein, Alissa R. Armstrong, R. Michael Gower, Igor Roninson Ph.D., Eugenia Broude, Mengqian Chen Ph.D., Hao Ji, Chang-Uk Lim, Hongjun Wang, Daping Fan, Peisheng Xu Ph.D., Hexin Chen

Faculty Publications

Myeloid cells are highly heterogeneous and play key roles in establishing an immunosuppressive tumor microenvironment (TME), but the mechanisms controlling their differentiation remain unclear. Using orthotopic murine breast cancer models, we investigated how interleukin-1α (IL-1α) influences this process. Deletion of host Il1α resulted in rejection of transplanted tumors. Single-cell RNA sequencing identified CX3CR1⁺ macrophages as the main source of IL-1α in the TME. Il1α deficiency disrupted monocyte–macrophage differentiation, reducing CX3CR1⁺ macrophages and increasing iNOS⁺ macrophages. Myeloid cells from Il1α⁻/⁻ hosts induced lower PD-1 and CTLA-4 expression in co-cultured CD8⁺ T cells than those from wild-type hosts. CellChat analysis showed …

Betting On The Future By Re-Discovering The Past: History Of Hospital Infrastructure In Early Las Vegas And Southern Nevada, Aidy Weeks

Library Faculty Research

In the summer of 2025, the library director began reviewing resources available from the University Libraries Special Collections Portal to learn about early hospital infrastructure in Las Vegas and Southern Nevada. Using the keyword “hospital”, they reviewed 1,000 records to locate primary resources that could help tell the story of Las Vegas’s first hospital and Southern Nevada early history. In total, they located photos, oral histories, city documents, and newspaper articles, to help put together a timeline of which hospitals, current events, and key figures were critical in establishing a medical presence in Las Vegas and Southern Nevada. Information was …

Reducing Work-Related Screen-Time In Healthcare Workers During Leisure Time (Reduce Screen) - A Randomized Controlled Trial, Karsten Bartels, Karan Shah, Emelind Sanchez Rodriguez, Julie T Hoffman, Megan L Rolfzen, Juana Mora Valdovinos, Afton L Hassett, Daniel I Sessler

Faculty, Staff and Student Publications

The ubiquitous availability of work-related applications on personal devices makes healthcare workers prone to working during leisure time. We tested the hypothesis that an intervention to reduce work-related screen time during a weekend off reduces stress in healthcare workers in a pragmatic parallel design randomized controlled trial between November 2021 and November 2023. Healthcare workers using a smartphone with a work email application were eligible. Randomization was 1:1 to no treatment or a threefold educational intervention to: 1) activate automated responses to emails received, 2) reduce screen time, and 3) uninstall work applications from personal devices. The primary outcome was …

Forecasting (Nano)Medical Technologies: Lessons From The Covid-19 Pandemic For Science And Society, Vuk Uskoković

Administration and Staff Articles and Research

Successful translation of medical devices from the bench to the bedside is conditioned by the accurate estimation of market opportunities. Because market conditions can change significantly over time, this assessment is challenging in the early stages of technological development. In this study a qualitative analysis of market trends and regulatory frameworks was conducted to assess how transient market conditions influence the development and distribution of nanomedical technologies, using nanotechnologies developed for COVID-19 as the example. The findings demonstrate that the unpredictable nature of the COVID-19 pandemic has led to a volatile market for nanomedical solutions, discouraging private sector investment and …

Quality Control Of Actinium-225 And 225ac-Radiopharmaceuticals: Francium-221 To Be Or Not To Be?, Miguel Toro-Gonzalez, Luke Wheeless, Vijai Kumar Reddy Tangadanchu, Cory Hawkins, Shannon Provo, William Smith, Michael Hommen, Dan Devries, Jim Harvey, Tyler Drum, Diane S Abou

2020-Current year OA Pubs

BACKGROUND: Actinium-225 radiopharmaceuticals have drawn great interest in cancer therapy due to their tumor-specific delivery of cytotoxic alpha-particles. Quality control (QC) is critical for these potent agents and there is currently no consensus for best practice of actinium-225 QC. Detection of actinium-225 (T

RESULTS: The plastic silicon scanner resulted in RCY% differences between 30 min and > 5 h evaluations, whereas the gas-filled proportional counter, when varying voltages, showed minor differences. Similarly, HPGe-TLC demonstrated equivalent RCY% between both equilibria. The NaI(Tl), LSC- TLC, and HPLC-gamma counting significantly underestimated RCY% or RCP% at 30 min. Considering gamma well counting LOQ and

CONCLUSION: …

Premature Aging In Serious Mental Illness, Breno S Diniz, Gabriel R Fries, Chia-Ling Kuo, Ming Xu, Eric J Lenze

Faculty, Staff and Student Publications

Serious mental illnesses (SMIs), including major depressive disorder, bipolar disorder, and schizophrenia, have long been linked to cognitive decline, multiple chronic medical conditions, and premature mortality. These factors significantly contribute to the severe disability seen in SMIs, extending beyond the severity of psychopathology and indicating a premature aging phenotype associated with these conditions. The mechanisms that underlie the relationship between SMIs and the premature aging phenotype are not well understood, but recent evidence suggests that individuals with SMIs may exhibit accelerated biological aging. In this review, we present a comprehensive analysis of the current literature, demonstrating the potential association of …

Foxo1 Inhibition And Fadd Knockdown Have Opposing Effects On Anticancer Drug-Induced Cytotoxicity And P21 Expression In Osteosarcoma Cells, Danielle Walker, Antanay Hall, Alexis Bonwell, Nancy Gordon, Danielle Robinson, Mario G Hollomon

Faculty, Staff and Student Publications

Forkhead box class O1 (FOXO1) and fas-associated death domain (FADD) regulate cell death pathways and homeostatic processes such as cell cycle progression and apoptosis. FADD phosphorylation promotes nuclear localization of FOXO1, and FOXO1 regulates FADD expression. Therefore, it is plausible that FOXO1 and FADD have synergistic or antagonistic effects on cell cycle regulation and the response to anticancer drug treatment in cancer cells. In the present study, we report that AS1842856-mediated inhibition of FOXO1 reverses anticancer drug-induced cytotoxicity, while FADD knockdown increases anticancer drug-induced cytotoxicity in osteosarcoma (OS). Reversed anticancer drug-induced cytotoxicity was accompanied by G2/M cell cycle arrest and …

Plans4care, A Web Application Providing Caregivers Personalized Solutions To Manage Dementia-Related Care Challenges: Proof Of Concept And Efficacy Trial, Laura N. Gitlin, Eric Jutkowitz, Catherine V. Piersol, Sokha Koeuth, Taylor Sivori, Melinda J. Webster, Rachel N. Barnett, David L. Roth

Department of Occupational Therapy Faculty Papers

OBJECTIVE: Few dementia caregivers have access to evidence-based support programs. Web applications (app) may address this gap. Plans4Care, a web app, provides caregivers with on-demand personalized solutions to address care challenges. We present results of a proof-of-concept study and describe a trial protocol to test efficacy.

METHODS: To use Plans4Care, caregivers respond to brief onboarding questions, assess dementia patients' cognitive function, identify care challenges, and generate "action plans" (personalized strategies). Telehealth sessions with dementia-trained care advisors are available. A proof-of-concept study evaluated a clickable prototype using standardized technology scales to determine if >75 % scored positively on four criteria (acceptability, …

The Effects Of Percussion Therapy (Theragun™) On Recovery From Contraction-Induced Muscle Damage In Highly Trained Participants, Maja Gebauer, Oscar Chavez Jr., Jonathan W. Specht, Whitley C. Atkins, Christine M. Mermier, Michael Deyhle

International Journal of Exercise Science: Conference Proceedings

The Effects of Percussion Therapy (Theragun™) on Recovery from Contraction-Induced Muscle Damage in Highly Trained Participants

MAJA GEBAUER, OSCAR CHAVEZ JR., JONATHAN W. SPECHT, WHITLEY C. ATKINS CHRISTINE MERMIER & MICHAEL R. DEYHLE

Exercise Science Laboratory; Department of Health, Exercise, and Sport Sciences; University of New Mexico; Albuquerque, NM

Category: Doctoral

Advisor / Mentor: Deyhle, Michael ([email protected])

ABSTRACT

The impacts of percussion therapy on athletes is not fully understood. PURPOSE: Investigate the effects of a two-minute treatment with a percussion gun (Theragun™) on muscle soreness, ROM, and strength performance following eccentric exercise of the hamstring muscles in highly trained …

Real-Time Hemodynamic Deterioration Following Polymorphic Ventricular Tachycardia In A Patient With Preexisting Aicd Implanted With Lvad, Dhruvil Patel, Maya Guglin, Deepa Iyer, Chonyang Albert, Jagpreet Grewal, Kenneth Dulnuan

The VAD Journal

Ventricular arrhythmias (VAs) are common in patients with a left ventricular assist device (LVAD), but the literature remains inconclusive regarding the benefits of an automatic implantable cardioverter-defibrillator (AICD) in this population, especially in those with a preexisting device before LVAD implantation. Here, we report the acute hemodynamic consequences of polymorphic ventricular tachycardia in a patient with a preexisting biventricular AICD who was implanted with an LVAD (HeartMate 3). This case underscores the importance of considering AICD placement on a case-by-case basis and highlights the need for a well-designed study to establish its benefit in this population.