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Articles 8581 - 8610 of 324921
Full-Text Articles in Medicine and Health Sciences
Conditions Affecting The Gi Tract: The Dental Professional’S Role, Sherri M. Lukes, Rdh, Ms, Faadh
Conditions Affecting The Gi Tract: The Dental Professional’S Role, Sherri M. Lukes, Rdh, Ms, Faadh
The Journal of the Michigan Dental Association
This article explores the critical role dental professionals play in identifying gastrointestinal (GI) conditions through their oral manifestations. It provides an overview of various pathologies, including HPV-induced oropharyngeal cancer, gastroesophageal reflux disease (GERD), and inflammatory bowel diseases like Crohn’s and ulcerative colitis. The author describes specific oral signs, such as dental erosion and aphthous ulcerations, that can serve as early indicators of systemic disease. The piece advocates for an interdisciplinary approach to patient care, emphasizing that dental practitioners are often on the front lines of diagnosing serious systemic health issues.
News You Need, David Foe
News You Need, David Foe
The Journal of the Michigan Dental Association
This comprehensive news section covers a wide range of association updates, including previews of the 2026 Annual Session and the Mission of Mercy volunteer event. It provides critical "Dental Benefit Briefs" regarding claims appeals, CMS rule changes for prior authorization, and code deletions affecting reimbursement. The source also features a Q&A with the new ADA 9th District Trustee and highlights new guidelines for using generative AI in dental journalism. Additionally, it reports on community grants and charitable programs like Livingston District’s "Gold for Food".
What Ce Do I Need To Take To Renew My Dea License?, Rachel Sinacola Dds, Ms
What Ce Do I Need To Take To Renew My Dea License?, Rachel Sinacola Dds, Ms
The Journal of the Michigan Dental Association
This resource provides practical answers to member questions about licensure and association events. It explains the new DEA requirement for a one-time eight-hour training on substance use disorders and highlights available MDA courses that fulfill this mandate. The source also details significant changes to the MDA Annual Session registration process, which now uses a simplified pass system rather than individual course registration. Additionally, it offers guidance on renewing dental licenses through the MiPLUS platform and downloading the MDA member logo.
When Toxic Behaviors Sneak Into Practice, Amrita Patel, Dds
When Toxic Behaviors Sneak Into Practice, Amrita Patel, Dds
The Journal of the Michigan Dental Association
This article addresses the challenge for new dentists in identifying and managing toxic workplace behaviors. It details common red flags such as chronic negativity, poor communication, "blame culture," and excessive production pressure that compromises ethics. The author explains how these environments can lead to burnout and practicing defensively rather than confidently. The source emphasizes the importance of developing self-awareness, seeking external mentorship, and establishing professional boundaries. It concludes that recognizing when to leave an unhealthy practice is an act of professional self-respect and essential for long-term career satisfaction.
The Back Page: Helping The Homeless Through The Delonis Oral Health Initiative, Sarah Tomaka, Dds
The Back Page: Helping The Homeless Through The Delonis Oral Health Initiative, Sarah Tomaka, Dds
The Journal of the Michigan Dental Association
This feature story highlights a student-led initiative at the University of Michigan School of Dentistry to provide dental care to Ann Arbor's unhoused population. Through the Delonis Oral Health Initiative, students have partnered with a local shelter to connect over 100 vulnerable patients with essential treatment. The article discusses the profound impact of treating dental pain on an individual's ability to pursue stable housing and a better life. It also showcases how the program provides students with meaningful leadership and community service experience while addressing a critical gap in public health.
Histologic Analysis Of Peri-Implant Soft Tissue Around External Hexagon And Morse Taper Implant Connections, Daniel Sartorelli Marques De Castro, Jefferson David Melo De Matos, Jozely Francisca Mello Lima, Guilherme Da Rocha Scalzer Lopes, Mário Alexandre Coelho Sinhoreti, Daher Antonio Queiroz, Carlos Do Reis Pereira De Araújo
Histologic Analysis Of Peri-Implant Soft Tissue Around External Hexagon And Morse Taper Implant Connections, Daniel Sartorelli Marques De Castro, Jefferson David Melo De Matos, Jozely Francisca Mello Lima, Guilherme Da Rocha Scalzer Lopes, Mário Alexandre Coelho Sinhoreti, Daher Antonio Queiroz, Carlos Do Reis Pereira De Araújo
Faculty, Staff and Student Publications
Background: Twenty patients rehabilitated with screw-retained full-arch implant-supported prostheses functioning for at least one year were included.
Material and methods: This clinical study included 20 patients rehabilitated with screw-retained full-arch implant-supported prostheses in function for at least 1 year. Participants were allocated into two groups according to the implant-abutment connection design: external hexagon (EH; n = 10) and Morse taper (MT; n = 10). One peri-implant soft tissue biopsy specimen was obtained from each patient and processed for hematoxylin-eosin staining. Histological evaluation assessed epithelial hyperplasia, epithelial organization, inflammatory infiltrate intensity, and connective tissue fibrosis. Data normality was assessed using the …
Airway Management In Thoracic Anesthesia: Eactaic Consensus Document, Manuel Granell, Caroline Vanpeteghem, Jo Mourisse, Mert Senturk, Laszlo Szegedi, Mohamed El Tahan, Chirojit Mukherjee, Izumi Kawagoe, Waheed Karzai, Marcus Lance
Airway Management In Thoracic Anesthesia: Eactaic Consensus Document, Manuel Granell, Caroline Vanpeteghem, Jo Mourisse, Mert Senturk, Laszlo Szegedi, Mohamed El Tahan, Chirojit Mukherjee, Izumi Kawagoe, Waheed Karzai, Marcus Lance
Anaesthesiology, East Africa
This article is the third in a series of articles prepared as part of a comprehensive, international and professional society–approved consensus project to advise on thoracic anesthesia. It represents the views and structured opinions of experts delegated to the Airway Management Task Force of the Thoracic Subcommittee of the European Association of Cardiothoracic Anaesthesiology and Intensive Care (EACTAIC). This review highlights the main concepts and expert opinion of international leaders on the task of lung isolation and separation, as well as the current recommendations on the benefits and disadvantages of different devices in both routine and difficult airway scenarios. The …
Monitoring In Thoracic Anesthesia: Eactaic Consensus Document, Mohamed El Tahan, Edda Tschernko, Tamás Végh, Jo Mourisse, Mert Sentürk, Katarina Lenartova, Maria Alberici, Thomas Wasserscheid, Nandor Marczin, Marcus Lance
Monitoring In Thoracic Anesthesia: Eactaic Consensus Document, Mohamed El Tahan, Edda Tschernko, Tamás Végh, Jo Mourisse, Mert Sentürk, Katarina Lenartova, Maria Alberici, Thomas Wasserscheid, Nandor Marczin, Marcus Lance
Anaesthesiology, East Africa
This is the first part of a series of articles prepared for a comprehensive, international, and professional society–approved consensus project to advise on thoracic anesthesia. It represents the views and structured opinions of experts delegated to the General Management: Monitoring Task Force of the Thoracic Subcommittee of the European Association of Cardiothoracic Anaesthesiology and Intensive Care (EACTAIC). This review highlights international leaders’ main concepts and expert opinions on how monitoring is the core task of anesthesiologists involved in the care of thoracic patients, providing recommendations for assessing principal organ systems and using different devices in routine and specialized scenarios. The …
Key Predictors Of Postpartum Depression And Anxiety Symptoms Among Mothers In Kilifi, Kenya: A Machine Learning Approach, Faith Benson, Rachel Odhiambo, Willie Brink, Anthony Ngugi, Akbar Waljee, Eileen Weinheimer-Haus, Cheryl Moyer, Ji Zhu, Amina Abubakar
Key Predictors Of Postpartum Depression And Anxiety Symptoms Among Mothers In Kilifi, Kenya: A Machine Learning Approach, Faith Benson, Rachel Odhiambo, Willie Brink, Anthony Ngugi, Akbar Waljee, Eileen Weinheimer-Haus, Cheryl Moyer, Ji Zhu, Amina Abubakar
Institute for Human Development, East Africa
Background:
The burden of maternal postpartum depression and anxiety is disproportionately high in sub-Saharan Africa (SSA), yet the use of advanced analytical methods to capture the complex interplay of variables influencing these conditions remains underexplored.
Objective:
To apply machine learning (ML) methods to predict depressive and anxiety symptoms in postpartum mothers and to identify key and actionable predictors.
Methods:
This cross-sectional study included 1,995 biological mothers of singleton infants aged 0–6 months, using survey data collected between March 2023 and March 2024 in Kaloleni and Rabai sub-counties, Kilifi County, Kenya, within the Kaloleni–Rabai Health and Demographic Surveillance …
Wellness Connection Newsletter March 2026, Roger Williams University School Of Law
Wellness Connection Newsletter March 2026, Roger Williams University School Of Law
Life of the Law School (1993- )
No abstract provided.
Himmelfarb Library Liaison Letter - March 2026, The George Washington University, Himmelfarb Health Science Library
Himmelfarb Library Liaison Letter - March 2026, The George Washington University, Himmelfarb Health Science Library
Himmelfarb Library Liaison Letters
No abstract provided.
Results From Jail-Based Substance Use Treatment In Tooele County, Matthew Huntington, Shianne Anderson
Results From Jail-Based Substance Use Treatment In Tooele County, Matthew Huntington, Shianne Anderson
Outcomes and Impact Quarterly
This article describes the development and outcomes of a jail-based substance use treatment program in Tooele County, Utah. The program addresses the elevated overdose risk among individuals leaving incarceration through education, peer support, and coordinated reentry planning. Program outcomes include reduced recidivism and improved connection to recovery supports.
Stroke Increases Motor Output Variability During Maximal Voluntary Isometric Contractions Of Knee Extensor Muscles In Adults, Zhilun Zhou, Stephanie Christine Wolfe, Brian Schmit, Matthew J. Durand, Sandra Hunter, Allison Hyngstrom
Stroke Increases Motor Output Variability During Maximal Voluntary Isometric Contractions Of Knee Extensor Muscles In Adults, Zhilun Zhou, Stephanie Christine Wolfe, Brian Schmit, Matthew J. Durand, Sandra Hunter, Allison Hyngstrom
Physical Therapy Faculty Research and Publications
Greater motor output variability (MOV, inconsistency and unsteadiness) during submaximal tasks post stroke is associated with poorer motor performance. However, little is known about MOV during maximal tasks and relationships with clinical measures of motor performance among stroke survivors. This study determined inconsistency (across discrete attempts) and unsteadiness (within a single attempt) during knee extension maximal voluntary isometric contractions (MVICs) in stroke survivors and neurotypical controls. Forty-three stroke survivors (28 female) and 31 age-matched neurotypical controls (15 female) performed a minimum of five knee extension MVICs with paretic and non-paretic legs (stroke) or dominant leg (controls). Inconsistency was calculated as …
Improving Equity Within The Holistic Admission Process Through Race-Neutral Holistic Review: A Before And After Cross-Sectional Study, Megan Eikenberry, Kylie Scott, Jaime González, Josh Subialka, Lacey Frankland, Patrice Ayala, Mark Kargela, Byron Russell
Improving Equity Within The Holistic Admission Process Through Race-Neutral Holistic Review: A Before And After Cross-Sectional Study, Megan Eikenberry, Kylie Scott, Jaime González, Josh Subialka, Lacey Frankland, Patrice Ayala, Mark Kargela, Byron Russell
Physical Therapy Faculty Publications
Introduction: The US Physical therapist (PT) workforce lacks racial and ethnic diversity, which may contribute to health disparities. Holistic review (HR) admission methods may improve workforce diversity by evaluating applicants' academic metrics, experiences, and personal attributes. Holistic review processes must adapt following the 2023 Supreme Court ruling prohibiting race-based admission criteria.
Review of literature: Holistic review criteria are program-specific and align with institutional and programmatic goals. While HR is shown to improve student body diversity, most PT education programs heavily emphasize academic metrics, which may disadvantage racial and ethnic minority (REM) applicants from acceptance. This study examines the racial and …
Trends In Health-Based Drinking Water Violations For Coliform Bacteria In The United States, Amber Lyon-Colbert, Kshipra Sharma
Trends In Health-Based Drinking Water Violations For Coliform Bacteria In The United States, Amber Lyon-Colbert, Kshipra Sharma
Public Health Faculty Publications
This research seeks to determine whether health-based drinking water violations for total coliforms have increased since the Revised Total Coliform Bacteria Rule established in 2013 and fully implemented in 2016 by the Environmental Protection Agency under the Safe Drinking Water Act; as well as determine the geographic regions, states and territories in the United States with the highest number of health-based Total Coliform Rule and Revised Total Coliform Rule violations. We obtained data for drinking water violations involving total coliform bacteria from the Safe Drinking Water Information System for 2000-2019 and trend analysis was completed by state, region, water source, …
Examining Rural Population Characteristics And Access To Care In 2022: A Study Of Health Professional Shortage Areas (Hpsas) And Medically Underserved Areas (Muas), Craig Holden, Shena Popat, Rachel Van Vleet, Shalanda Henderson, Carina Hoyer, Alana Knudson
Examining Rural Population Characteristics And Access To Care In 2022: A Study Of Health Professional Shortage Areas (Hpsas) And Medically Underserved Areas (Muas), Craig Holden, Shena Popat, Rachel Van Vleet, Shalanda Henderson, Carina Hoyer, Alana Knudson
ETSU/NORC Rural Health Research Center Policy Briefs
No abstract provided.
An Examination Of All-Payer Inpatient Rural Hospital Bypass, Craig D. Holden, Shena Popat, Alana Knudson, Marilyn G. Klug
An Examination Of All-Payer Inpatient Rural Hospital Bypass, Craig D. Holden, Shena Popat, Alana Knudson, Marilyn G. Klug
ETSU/NORC Rural Health Research Center Policy Briefs
No abstract provided.
A Joint Effort: Stakeholders' Perspectives Of Medication Management Reviews In Australian Residential Aged Care, Rajendra Gyawali, Marea O'Donnell, Rachel Jenkins, Amy D. Nguyen, Lalit Yadav, Rosemary Saunders, Fiona J. Clay, Johanna I. Westbrook, Karla Seaman, Magdalena Z. Raban
A Joint Effort: Stakeholders' Perspectives Of Medication Management Reviews In Australian Residential Aged Care, Rajendra Gyawali, Marea O'Donnell, Rachel Jenkins, Amy D. Nguyen, Lalit Yadav, Rosemary Saunders, Fiona J. Clay, Johanna I. Westbrook, Karla Seaman, Magdalena Z. Raban
Research outputs 2022 to 2026
Objective: Residential Medication Management Review (RMMR) is a government-funded pharmacist-led service to address medication-related problems, such as polypharmacy, which are prevalent in aged care. Despite known benefits, concerns remain about the service's effective implementation to benefit residents. We aimed to explore stakeholders' perspectives of the service and identify challenges and improvement opportunities. Method: A qualitative study was conducted using individual interviews and focus groups with 21 stakeholders, including general practitioners (GPs), a nurse practitioner, registered nurses, pharmacists and consumers. Audio transcripts of the discussions were thematically analysed using inductive coding. Results: Seven interconnected themes were identified, highlighting complexities in RMMR …
The Relationships Between Social Network Size, Loneliness And Personality In Individuals Living With A Neurological Condition: An Exploratory Study, Isabella Branson, Kate Turner, Mitchell Turner, Manja Laws, Leah Dempsey, Simon Laws, Mandy Stanley, Johnny Lo, Travis Cruickshank
The Relationships Between Social Network Size, Loneliness And Personality In Individuals Living With A Neurological Condition: An Exploratory Study, Isabella Branson, Kate Turner, Mitchell Turner, Manja Laws, Leah Dempsey, Simon Laws, Mandy Stanley, Johnny Lo, Travis Cruickshank
Research outputs 2022 to 2026
Background: People living with a neurological condition often report having smaller social networks and less frequent social contact, leading to greater loneliness and worse quality of life. This study explored the relationships between personality traits, social network size (SNS) and perceived loneliness in this population. Methods: Sixty-eight individuals diagnosed with a neurological condition participated in this study. Perceived loneliness was assessed using the UCLA Loneliness Scale – Version 3, SNS was evaluated by the Social Network Index and personality traits were examined using the NEO Factor Five Inventory. Path analysis was conducted to determine if loneliness was negatively associated with …
Work Challenges And Cancer-Related Cognitive Impairment: Level Of Education Accounts For Unmet Needs Beyond Cognitive Impairment Severity, Darren Haywood, Susan L. Rossell, Ashley Henneghan, Frank D. Baughman, Jennifer Haywood, Evan Dauer, Annika Hegde, Ahmed A. Moustafa, Nicolas H. Hart
Work Challenges And Cancer-Related Cognitive Impairment: Level Of Education Accounts For Unmet Needs Beyond Cognitive Impairment Severity, Darren Haywood, Susan L. Rossell, Ashley Henneghan, Frank D. Baughman, Jennifer Haywood, Evan Dauer, Annika Hegde, Ahmed A. Moustafa, Nicolas H. Hart
Research outputs 2022 to 2026
Purpose: Cancer-related cognitive impairment (CRCI) can impact cancer survivors’ return to work and occupational functioning for many years following the completion of cancer treatment. Understanding the characteristics of CRCI-related occupational difficulties and unmet supportive care needs is critical for the development of effective interventions. Within occupational roles, a higher level of education is typically associated with greater cognitive load and different demands. The objective of this study was to examine whether the level of education accounted for CRCI-related (a) occupational difficulties and (b) occupational unmet supportive care needs, beyond the contributions of perceived cognitive functioning and employment level. Methods: A …
Improving Vaccination In People With Ckd: Report From A National Kidney Foundation Working Group, Susan F. Massengill, Kenneth A. Andreoni, Keith A. Bellovich, Cheryl Courtlandt, Vimal K. Derebail, David L. Feldman, Gia J. Oh, John W. Sleasman, Kristina A. Bryant, Improving Vaccination In Ckd Working Group
Improving Vaccination In People With Ckd: Report From A National Kidney Foundation Working Group, Susan F. Massengill, Kenneth A. Andreoni, Keith A. Bellovich, Cheryl Courtlandt, Vimal K. Derebail, David L. Feldman, Gia J. Oh, John W. Sleasman, Kristina A. Bryant, Improving Vaccination In Ckd Working Group
Department of Surgery Faculty Papers
People with chronic kidney disease (CKD) are particularly vulnerable to vaccine-preventable infections. Therefore, the National Kidney Foundation organized a multidisciplinary working group, including people with CKD and family care partners, to develop recommendations to improve vaccination rates, vaccination effectiveness, and health care for the CKD population. A modified Delphi process was used to achieve consensus on the recommendations. Recommendations on vaccination in CKD patients were organized into these categories: (1) patient preferences; (2) assessing the vaccination status of patients with CKD; (3) assessing vaccine response in patients with CKD; (4) vaccination of immunocompromised patients; (5) vaccination in posttransplant patients; (6) …
The Social And Biological Frontiers Of Polio: Comparing Global Eradication Strategies, Srisai A. Turangi
The Social And Biological Frontiers Of Polio: Comparing Global Eradication Strategies, Srisai A. Turangi
Honors Program: Senior Projects (Public)
This paper provides a comparative analysis of the divergent global strategies for poliomyelitis (polio) eradication, examining the historical and structural contexts of developed nations – the United States and United Kingdom – alongside the enduring challenges in endemic regions such as Nigeria and Pakistan. Biomedical innovations like the Inactivated Polio Vaccine (IPV) and Oral Polio Vaccine (OPV) have helped bring the world to a state of almost complete global eradication, but progress is still uneven due to variations in funding, healthcare infrastructure, and the legacy of colonialism. Studies reveal how a framework where global health inequalities remained, allowed for resource-rich …
Exploring Clinician Decision-Making Behind Preoperative Ekg Orders In Primary Care, Joon Cha, Katerina C. Valavanis Md, Grant M. Greenberg M.D., M.H.S.A., M.A.
Exploring Clinician Decision-Making Behind Preoperative Ekg Orders In Primary Care, Joon Cha, Katerina C. Valavanis Md, Grant M. Greenberg M.D., M.H.S.A., M.A.
USF-LVHN SELECT
No abstract provided.
What Are We Doing Right? A Qualitative Analysis Of Health Disparity Conversations With Lgbtq+ Older Adults, Skylar Lung, Ashlee Randolph, Nyann Biery Ms, Lynn M. Wilson Do
What Are We Doing Right? A Qualitative Analysis Of Health Disparity Conversations With Lgbtq+ Older Adults, Skylar Lung, Ashlee Randolph, Nyann Biery Ms, Lynn M. Wilson Do
USF-LVHN SELECT
No abstract provided.
Effect Of Dynamic Fatigue Loading On The Adaptation And Retention Of Maxillary Single Dentures Reinforced With Digitally Constructed Zirconia And Cobalt–Chromium Frameworks, Ghada Elgindy, Fardos N Rizk, Marwa Ezzat Sabet, Hebatallah Tarek Mohamed
Effect Of Dynamic Fatigue Loading On The Adaptation And Retention Of Maxillary Single Dentures Reinforced With Digitally Constructed Zirconia And Cobalt–Chromium Frameworks, Ghada Elgindy, Fardos N Rizk, Marwa Ezzat Sabet, Hebatallah Tarek Mohamed
Dentistry
Background. The impact of dynamic fatigue loading on denture adaptation and retention is clinically important. Zirconia and cobalt–chromium (Co–Cr) frameworks enhance denture strength, but their performance under cyclic loading remains unclear. Objectives. The aim of the study was to evaluate the adaptation and retention of maxillary single dentures reinforced with digitally constructed Co–Cr or zirconia frameworks after a simulated 1 year of function. Material and methods. Three types of maxillary single dentures were constructed on maxillary master casts. Group A included maxillary dentures without reinforcement (control group), whereas groups B and C encompassed maxillary dentures reinforced with digitally designed and …
Evaluating Icd-11 Against Established Terminology Standards: A Dual-Framework Analysis, Kathy L. Giannangelo, Susan H. Fenton, Mary H. Stanfill
Evaluating Icd-11 Against Established Terminology Standards: A Dual-Framework Analysis, Kathy L. Giannangelo, Susan H. Fenton, Mary H. Stanfill
Faculty, Staff and Student Publications
Background
The healthcare world is evaluating and adopting the World Health Organization’s (WHO’s) International Statistical Classification of Diseases and Related Health Problems Eleventh Revision (ICD-11) for Mortality and Morbidity Statistics (MMS). The objective of this study is to evaluate the degree to which the ICD-11 Foundation and the ICD-11 MMS linearization adhere to accepted terminology practices.
Methods
This study consisted of an evaluation of the ICD-11 Foundation and ICD-11 MMS, using two established evaluation frameworks. Initial assessments were independently evaluated using publicly available documentation and designated one of five endpoints: meets criterion, partially meets criterion, does not meet criterion, criterion …
Information Extraction From Clinical Notes: Are We Ready To Switch To Large Language Models?, Yan Hu, Xu Zuo, Yujia Zhou, Xueqing Peng, Jimin Huang, Vipina K Keloth, Vincent J Zhang, Ruey-Ling Weng, Cathy Shyr, Qingyu Chen, Xiaoqian Jiang, Kirk E Roberts, Hua Xu
Information Extraction From Clinical Notes: Are We Ready To Switch To Large Language Models?, Yan Hu, Xu Zuo, Yujia Zhou, Xueqing Peng, Jimin Huang, Vipina K Keloth, Vincent J Zhang, Ruey-Ling Weng, Cathy Shyr, Qingyu Chen, Xiaoqian Jiang, Kirk E Roberts, Hua Xu
Faculty, Staff and Student Publications
Objectives: To assess the performance, generalizability, and computational efficiency of instruction-tuned Large Language Model Meta AI (LLaMA)-2 and LLaMA-3 models compared to bidirectional encoder representations from transformers (BERT) for clinical information extraction (IE) tasks, specifically named entity recognition (NER) and relation extraction (RE).
Materials and methods: We developed a comprehensive annotated corpus of 1588 clinical notes from 4 data sources-UT Physicians (UTP) (1342 notes), Transcribed Medical Transcription Sample Reports and Examples (MTSamples) (146), Medical Information Mart for Intensive Care (MIMIC)-III (50), and Informatics for Integrating Biology and the Bedside (i2b2) (50), capturing 4 clinical entities (problems, tests, medications, other treatments) …
03-17-26 Bor Hsc Committee Notice Of Meeting, Patricia Serna
03-17-26 Bor Hsc Committee Notice Of Meeting, Patricia Serna
HSC Committee (A subcommittee of the UNM Board of Regents)
03-17-26 BOR HSC Committee Notice of Meeting
Pharmacogenetics Of Cyp3a5 In Pediatric Patients With Eosinophilic Esophagitis., Janelle R. Noel-Macdonnell Phd, Norah Almahbub, Erin C. Boone, Wendy Y. Wang, Dilyara Cheranova, Lisa Harvey, Valentina Shakhnovich, Rachel Chevalier
Pharmacogenetics Of Cyp3a5 In Pediatric Patients With Eosinophilic Esophagitis., Janelle R. Noel-Macdonnell Phd, Norah Almahbub, Erin C. Boone, Wendy Y. Wang, Dilyara Cheranova, Lisa Harvey, Valentina Shakhnovich, Rachel Chevalier
Manuscripts, Articles, Book Chapters and Other Papers
Eosinophilic esophagitis (EoE) is an atopic inflammatory disease with limited treatment options. Though swallowed topical steroids are commonly used, they are not effective in all patients. We investigated the presence of CYP3A4/5 and ABCB1 (P-glycoprotein) mRNA in esophageal tissue and its differential expression by genotype in pediatric patients. Esophageal tissue biopsies were obtained from pediatric patients undergoing standard of care endoscopy. Levels of CYP3A4, CYP3A5, and ABCB1 mRNA were measured using droplet digital PCR and compared across patients with and without EoE. Genotypes for common, clinically relevant CYP3A5 variants were evaluated in a cohort of individuals with and without EoE. …
E3 Ubiquitin Ligases And Asthma Relief, Ajay P. Nayak
E3 Ubiquitin Ligases And Asthma Relief, Ajay P. Nayak
Department of Medicine Faculty Papers
No abstract provided.