Medicine and Health Sciences Commons^™

New York State Emergency Department Assessment Treatment And Referral Of Individuals Presenting To The Emergency Department With Opioid Use Disorder, Macia Victoria Drummond

Theses & Dissertations

Opioid dependence and addiction are classified as severe medical conditions that cause adverse effects on the individual, their family, and society as a whole. The increasing number of opioid overdose cases and deaths has posed a significant challenge for emergency departments (EDs) as they play a crucial role in providing immediate medical attention to patients with opioid use disorder (OUD). The consequences of OUD are alarming, with high morbidity and mortality rates. The purpose of this study was to examine the policies, practices, and barriers to adherence to nationally recognized clinical best practices for treating patients with OUD in New …

A Psychometric Validation Of The Provider Responses, Treatment, And Care For Trafficked People Instrument, Shaneke O. Pryce

Theses & Dissertations

Background

Human trafficking (HT) is often referred to as modern-day slavery, where force, fraud, or coercion is used to lure an individual into a life of labor or sexual exploitation. Although trafficked persons commonly interface with the healthcare setting, they are often unidentified and returned to the trafficked population. Previous studies have shown that while in captivity, trafficked persons have accessed medical care on various occasions, seeking treatments ranging from minor ailments to more severe ones at emergency departments, primary care clinics, and specialized clinics for sexual and reproductive health (Chisolm-Straker et al., 2016; Lederer &Wetzel, 2014). The inability to …

First Presentation With Neuropsychiatric Symptoms In Autosomal Dominant Alzheimer's Disease: The Dominantly Inherited Alzheimer's Network Study, Antoinette O'Connor, Helen Rice, Josephine Barnes, Natalie S. Ryan, Kathy Y. Liu, Ricardo Francisco Allegri, Sarah Berman, John M. Ringman, Carlos Cruchaga, Martin R. Farlow, Jason Hassenstab, Jae-Hong Lee, Richard J. Perrin, Chengjie Xiong, Brian Gordon, Allan I. Levey, Alison Goate, Neil Graff-Radford, Johannes Levin, Mathias Jucker, Tammie Benzinger, Eric Mcdade, Hiroshi Mori, James M. Noble, Peter R. Schofield, Ralph N. Martins, Stephen Salloway, Jasmeer Chhatwal, John C. Morris, Randall Bateman, Rob Howard, Suzanne Reeves, Nick C. Fox

Research outputs 2022 to 2026

Behavioural changes and neuropsychiatric symptoms (NPS) commonly occur in Alzheimer’s disease (AD) but may not be recognised as AD-related when they are the presenting feature. NPS are important as they are associated with greater functional impairment, poorer quality of life, accelerated cognitive decline and worsened caregiver burden.1 Autosomal dominant AD (ADAD), although < 1% of total AD cases, provides a valuable opportunity to study the clinical heterogeneity of AD. The young age at onset reduces the prevalence of age-related comorbid pathologies and the near 100% penetrance of pathogenic mutations reduces the likelihood of misdiagnosis.2 Anxiety and depression commonly occur in ADAD family members, with increased levels of depression having been found among predementia female mutation carriers.3 Subsequent studies, however, have shown that anxiety and/or depression are common regardless of mutation status, occurring in almost one in three at-risk individuals, with one study reporting a higher rate of depression in non-carriers (17%) than asymptomatic carriers (5%).4 5 Despite the high frequency of NPS in ADAD families, relatively little is known about the proportion of ADAD cases who present with predominantly behavioural symptoms. Our aims were to assess the first reported clinical change in symptomatic ADAD, to compare presentations across genotypes, and to compare cognitive performance between behavioural and cognitive-led presentations.

Multifactorial Profiling Of Epigenetic Landscapes At Single-Cell Resolution Using Multi-Tag, Michael P Meers, Geneva Llagas, Derek H Janssens, Christine A Codomo, Steven Henikoff

2020-Current year OA Pubs

Chromatin profiling at locus resolution uncovers gene regulatory features that define cell types and developmental trajectories, but it remains challenging to map and compare different chromatin-associated proteins in the same sample. Here we describe Multiple Target Identification by Tagmentation (MulTI-Tag), an antibody barcoding approach for profiling multiple chromatin features simultaneously in single cells. We optimized MulTI-Tag to retain high sensitivity and specificity, and we demonstrate detection of up to three histone modifications in the same cell: H3K27me3, H3K4me1/2 and H3K36me3. We apply MulTI-Tag to resolve distinct cell types and developmental trajectories; to distinguish unique, coordinated patterns of active and repressive …

Distinct Hyperuricemia Trajectories Are Associated With Different Risks Of Incident Diabetes: A Prospective Cohort Study, Jia Liu, Huiying Pan, Yue Liu, Mengying Guan, Xia Li, Shuo Chen, Xingyao Tong, Yanxia Luo, Xiaonan Wang, Xinghua Yang, Xiuhua Guo, Jingbo Zhang, Lixin Tao

Research outputs 2022 to 2026

Background and aim: Conflicting results suggest a link between serum uric acid and diabetes and previous studies ignored the effect of continuous exposure of serum uric acid on diabetes risk. This study aims to characterize hyperuricemia trajectories in middle-aged adults and to examine its potential impact on diabetes risk, considering the role of obesity, dyslipidemia, and hypertension. Methods and results: The cohort included 9192 participants who were free of diabetes before 2013. The hyperuricemia trajectories during 2009–2013 were identified by latent class growth models. Incident diabetes during 2014–2018 was used as the outcome. Modified Poisson regression models were used to …

Does Antibiotic Awareness Campaigns Exposure Decrease Intention To Demand Antibiotic Treatment? Testing A Structural Model Among Parents In Western Australia, Aaron Lapuz Alejandro, Wei Wei Cheryl Leo, Mieghan Bruce, Kaymart Gimutao

Research outputs 2022 to 2026

Antimicrobial resistance (AMR) is one of the key public health concerns the world is facing today. The effect of antibiotic awareness campaigns (AACs) on consumer behaviour has been documented in the literature with mixed results. Understanding the mechanism for how AACs affect target populations is vital in designing effective and tailored campaigns. Using structural equation modelling our study examined the relationships among people's exposure to antibiotic awareness campaigns, knowledge of AMR prevention, AMR risk perception, and intention to seek antibiotic treatment. This study also tested the moderating effect of anxiety and societal responsibility on preventing AMR, and on their intention …

The Validity Of Hawkin Dynamics Wireless Dual Force Plates For Measuring Countermovement Jump And Drop Jump Variables †, Andrew J. Badby, Peter D. Mundy, Paul Comfort, Jason P. Lake, John J. Mcmahon

Research outputs 2022 to 2026

Force plate testing is becoming more commonplace in sport due to the advent of commercially available, portable, and affordable force plate systems (i.e., hardware and software). Following the validation of the Hawkin Dynamics Inc. (HD) proprietary software in recent literature, the aim of this study was to determine the concurrent validity of the HD wireless dual force plate hardware for assessing vertical jumps. During a single testing session, the HD force plates were placed directly atop two adjacent Advanced Mechanical Technology Inc. in-ground force plates (the “gold standard”) to simultaneously collect vertical ground reaction forces produced by 20 participants (27 …

The Complement System And Human Autoimmune Diseases, Samantha L Coss, Danlei Zhou, Gilbert T. Chua, Rabheh Abdul Aziz, Robert P. Hoffman, Yee Ling Wu, Stacy P. Ardoin, John P. Atkinson, Chack-Yung Yu

2020-Current year OA Pubs

Genetic deficiencies of early components of the classical complement activation pathway (especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic autoimmune disease systemic lupus erythematosus (SLE), but their prevalence is extremely rare. In contrast, isotype genetic deficiency of C4A and acquired deficiency of C1q by autoantibodies are frequent among patients with SLE. Here we review the genetic basis of complement deficiencies in autoimmune disease, discuss the complex genetic diversity seen in complement C4 and its association with autoimmune disease, provide guidance as to when clinicians should suspect and test for complement deficiencies, and outline …

Optimizing Collaboration Among Clinical Pharmacy Specialists And Behavioral Health Providers In The Primary Care Setting To Increase Mental Health Access, Ryan Ferris, Christine Doran, Bonnie Jiron, Dara L. Johnson

Providence Pharmacy PGY2 Program at Providence Medical Group 2023

No abstract provided.

Irritable Bowel Syndrome: Proposed Mechanisms Of Pathophysiology And The Underlying Dysregulation Of Brain-Gut Interaction, Hailey Haddix

Senior Honors Theses

Irritable bowel syndrome (IBS) is a disease of the gastrointestinal tract affecting approximately 11-21% of people worldwide (Xiao et al., 2021). This research focuses on the dysregulation of gut homeostasis in IBS and explains how the pathophysiology of the gut is controlled by the bidirectional brain-gut axis. The mechanisms of the brain-gut axis consist of neuro-immune cross talk, neuro-hormone cross talk, microbiome-gut signaling, and the HPA-axis. Each of these contribute to one or more of the possible phenotypes of gut pathophysiology, which could include intestinal permeability, visceral hypersensitivity, and motility disturbance (Xiao et al., 2021). Stress is also an important …

Infertility: An Evaluation Of Treatment Modalities And Ethical Considerations, Elise Ferenczy

Senior Honors Theses

This thesis reviews a variety of options for treatment of infertility, along with ethical considerations for each. The basis for ethical concerns will be primarily a biblical worldview, as the goal is to support Christian couples in decisions regarding infertility treatment. The biblical worldview is outlined to provide readers with an understanding of its core principles, and the Bible is used as the primary source for ethical discussion. The most common etiologies of infertility are outlined, followed by treatment modalities grouped by category. While some modalities present very few ethical concerns, others require careful consideration in many regards. Many of …

Strengthening The Understanding Of South Partnerships And Rigor In Addressing Social Determinants Of Child And Adolescent Mental Health, Manasi Kumar

Brain and Mind Institute

The Journal of Adolescent Health's current supplement presents the work of a highly active team of researchers who are focusing on developing a strong body of evidence around child and adolescent mental health in Sub-Saharan Africa. The supplement lays out scholarship generated through years of partnership between researchers based in the United States—some of whom are from Sub-Saharan context, specifically Uganda—in connecting applied social work, community mental health for children and adolescents, and family development. The work comprises a series of articles embedded within several National Institutes of Health–funded grants by authors based in the United States in partnership with …

An Evaluation Of Hospital-Based Health Technology Assessment Processes In The United States., Scott Skinner

Electronic Theses and Dissertations

This research study explored the practices of hospital-based health technology assessment (HTA) in the U.S., as experienced by healthcare technology management (HTM) professionals. HTA can play an important role in helping to evaluate health technologies at both the macro (e.g., policy) level as well as at the micro (e.g., institutional) level of the public health ecosystem (C. S. Goodman, 2004). HTA seeks to broadly evaluate the effects, properties, and other impacts of various health technologies (C. S. Goodman, 2004). Common goals of HTA are to evaluate the safety, effectiveness, and cost-benefit of health technologies. A primarily phenomenological approach was used …

The Influences Of The Public Health Care System And Education System On The Economic Growth Of Swaziland, Grace Greer

International and Global Studies Undergraduate Honors Theses

The Kingdom of Eswatini, also known as Swaziland, has one of the youngest populations in the world with over 70% of citizens being under the age of 18 years old. This creates a substantial opportunity for economic, social, and educational growth in a country previously plagued with diseases such as HIV/AIDS, poor health care infrastructure cutting off thousands from basic care, and an educational system with a very low attendance rate and an even lower graduation rate. By evaluating the root causes of such issues dating back to the colonial era there is an opportunity to reprioritize health care and …

Genetic Mutations Of KCa2.3 And KCa3.1 Channels Affect Ca2+ Sensitivity, Razan Orfali

Pharmaceutical Sciences (PhD) Dissertations

The Ca²⁺-activated potassium channels K_Ca channels are a unique family of potassium channels activated by intracellular calcium. K_Ca channels are critical for maintaining K⁺ homeostasis and modulate several physiological processes, from the firing properties of neurons to the control of the transmitter release. The Ca²⁺ sensitivity of these channels allows intracellular Ca²⁺ to regulate the electrical activity of the cell membrane. Increased Ca²⁺ sensitivity of K_Ca channels caused by gain of function mutations (GOF) in the KCNN genes results in a broad spectrum of human channelopathies, including Zimmermann- Laband syndrome (ZLS), …

Lymphatic Dysfunction And Associated Systemic Inflammation In Lymphedema, Assessed By Nirf-Li Imaging And Plasma Cytokine/Chemokine Analysis, Anna Vang

Dissertations and Theses (Open Access)

Breast cancer-related lymphedema (BCRL) manifests as swelling of the upper extremities and trunk as a result of lymphatic fluid buildup due to radiation therapy (RT), surgical lymph node removal, or chemotherapy. As there is currently no cure, BCRL treatment aims to improve quality of life (QOL). First-line treatment involves specialized massage therapy and the use of compression garments. Second-line treatments include reparative lymphatic microsurgeries such as lymphovenous bypass (LVB) and/or vascularized lymph node transplant (VLNT). There is a need for better understanding of the etiology of BCRL and lymphatic microsurgery outcomes. Blood specimens and near-infrared fluorescent lymphatic imaging (NIRF- LI)data …

A Research Review Of Antidepressants For The Treatment Of Major Depressive Disorder, Connor Grady

Senior Honors Theses

The prevalence of major depressive disorder (MDD) in the U.S. has been significantly on the rise between 2015 and 2020, with adolescents and young adults (ages 18-34) contributing the most to this increase (Goodwin et al., 2022). The trend represents a disturbing downturn in the mental health of U.S. adults and warrants close attention and consideration. As the case number of MDD has continuously risen in the recent past, medical practitioners have been searching for more effective solutions. The techniques for combating the symptoms and curing the disease have varied, but one option consistently respected throughout the literature has been …

Anti-Vaccination: Addressing Vaccine Hesitancy And Its Consequences For Modern Public Health Policy, Joshua Bird

Senior Honors Theses

Modern vaccination is arguably the most significant medical achievement in human history. Through widespread vaccination, populations are no longer susceptible to diseases that plagued humanity for most of its existence (measles, rubella, smallpox). While vaccinations have largely shown themselves as safe and efficacious under most circumstances, small but considerable portions of the worldwide population reject vaccination for various social, religious, and political reasons. Research indicates that vaccine hesitancy spans all socioeconomic boundaries, affecting patients and their physicians. To explore the underlying themes of vaccine hesitancy and their relationship to loss aversion and omission bias, a study of various factors underlying …

Analysis Of Vein Grafting Versus Arteriovenous Loop In Microvascular Head And Neck Reconstruction: Multicenter Series Of 36 Patients, Kaitlynne Y. Pak, Spencer R. Anderson, Tyler L. Langenfeld, Kenneth Tan, Allison Slijepcevic, Sunishka Wimalawansa, Yadranko Ducic, Mark K. Wax, Sameep P. Kadakia

Orthopaedic Surgery Faculty Publications

Background: The utilization of an arteriovenous loop is an underreported technique that affords the creation of reliable vascular options. Understanding the efficacy and impacting variables of microvascular reconstruction with an arteriovenous loop can be critical to its use.

Methods: Multi-institutional study of 36 patients who underwent vein grafting or AV loop with free tissue transfer.

Results: 58.3% of patients received prior radiation and 38.9% prior flap reconstruction. Flap success for vein grafting was 76% and AV loop was 100% (p = 0.16). Success for the radiated cohort was 90.5% and non-radiated 80% (p = 0.63). Flap success for the radiated, …

Gender Role Conflict Experienced By Baccalaureate Level Male Nursing Students At The University Of Southern Mississippi, Brantley Snowden

Honors Theses

This study aims to determine the presence of gender role conflict experienced by male nursing students at the University of Southern Mississippi. Thirty-one male nursing students participated in this study. A 55-question survey was distributed via email to men in the baccalaureate nursing program at the University of Southern Mississippi. The survey contained a brief demographic section and a 53-question Likert scale section. The Likert scale questions were adopted from two validated surveys; the Inventory of Male Friendliness in Nursing Programs (IMFNP), and the Gender Role Conflict Scale – Short Form (GRCS-SF). Thirty questions were derived from the IMFNP and …

Exploring Relationships And Intimacy With Adults With Intellectual And/Or Developmental Disabilities (I/Dd), Gabrielle Kennedy, Jazminne Orozco Arteaga, Thais Petrocelli

Spring 2023 Virtual OTD Capstone Symposium

This capstone project, Exploring Relationships and Intimacy with Adults with Intellectual and/or Developmental Disabilities (I/DD), was completed by a Doctor of Occupational Therapy candidate at the University of St. Augustine for Health Sciences. The purpose of the project is to increase adults with I/DD's access to intimate partner relationships, sexual expression, and occupations related to intimacy by providing adaptive, community-centered, and meaningful resources.

The current occupational deprivation that the population experiences surrounding intimacy, sexual expression, and intimate partner relationships must be addressed to improve the population’s overall quality of life, health, and well-being. This project aims to inspire and …

Mental Health Awareness Month Display, Isabella Piechota, Arianna Tillman, Kalea Brown

Library Displays and Bibliographies

A bibliography created to accompany a display about Mental Health Awareness Month in May 2023 at the Leatherby Libraries at Chapman University.

Therapies In Stiff-Person Syndrome: Advances And Future Prospects Based On Disease Pathophysiology, Marinos Dalakas

Department of Neurology Faculty Papers

Among the glutamic acid decarboxylase (GAD)-antibody-spectrum disorders, the most common phenotypic subset is the stiff-person syndrome (SPS), caused by impaired GABAergic inhibitory neurotransmission and autoimmunity characterized by very high titers of GAD antibodies and increased GAD-IgG intrathecal synthesis. If not properly treated or untreated because of delayed diagnosis, SPS progresses leading to disability; it is therefore fundamental to apply the best therapeutic schemes from the outset. This article is focused on the rationale of specific therapeutic strategies based on the SPS pathophysiology targeting both the impaired reciprocal GABAergic inhibition to symptomatically improve the main clinical manifestations of stiffness in the …

From Inpatient Facility To The Everyday Classroom - Examining The Process Of Reintegration For Arkansas Youths, Grace Webb

Honors Theses

This thesis focuses on analyzing the current policies set in place within the state of Arkansas for student reintegration following a prolonged absence from school due to mental health issues. It is designed to explore what barriers and disconnections there are between mental health care and continued care after discharge of youths from an inpatient mental health facility and re-entry into the classroom. Within this thesis, current conditions impacting youth mental health and education are explored, as well as current school counseling plans throughout four school districts in various regions across the state. To my knowledge gathered from my findings, …

Oncolytic Virus Immunotherapy: Development And Potential For Cancer Treatment, Olivia Guinness

Honors Scholar Theses

The American Cancer Society estimates that in 2023, 1,958,310 new cancer cases and 609,820 cancer deaths will occur in the United States [16]. A promising therapeutic option that has been supported by recent clinical trials is the use of oncolytic viruses to treat malignant tumors. The mechanism of action of existing treatments, such as chemotherapy, radiotherapy, and surgery, differs from that of oncolytic virus therapy because oncolytic viruses are able to affect cancer cells with specificity, minimizing side effects. When infecting a normal, non-cancerous cell, oncolytic viruses do not replicate, leaving healthy cells unaffected. In tumor cells, oncolytic viruses will …

Inhibition Of Gap Junction Formation Prior To Implantation Of Bone Marrow-Derived Mesenchymal Cells Improves Function In The Ischemic Myocardium, Santipongse Chatchavalvanich, Robert A. Boomsma, Jack M. Tietema, David Geenen

Open Access Publishing Support Funded Articles

Bone marrow-derived mesenchymal stem cells (BM-MSC) are reported to induce beneficial effects in the heart following ischemia, but a loss of these cells within hours of implantation could significantly diminish their long-term effect. We hypothesized that early coupling between BM-MSC and ischemic cardiomyocytes through gap junctions (GJ) may play an important role in stem cell survival and retention in the acute phase of myocardial ischemia. To determine the effect of GJ inhibition on murine BM-MSC in vivo, we induced ischemia in mice using 90 min left anterior descending coronary artery (LAD) occlusion followed by BM-MSC implantation and reperfusion. The inhibition …

Refinement Of Saliva Microrna Biomarkers For Sports-Related Concussion, Steven D. Hicks, Cayce Onks, Raymond Y. Kim, Kevin J. Kim, Kevin J. Zhen, Jayson Loeffert, Andrea C. Loeffert, Robert P. Olympia, Gregory Fedorchak, Samantha Devita, Zofia Gagnon, Callan Mcloughlin, Miguel M. Madeira, Scott L. Zuckerman, Timothy Lee, Matthew Heller, Chuck Monteith, Thomas R. Campbell, Christopher Neville, Elise Fengler, Michael N. Dretsch

Rehabilitation Sciences Faculty Publications

Purpose

Recognizing sport-related concussion (SRC) is challenging and relies heavily on subjective symptom reports. An objective, biological marker could improve recognition and understanding of SRC. There is emerging evidence that salivary micro-ribonucleic acids (miRNAs) may serve as biomarkers of concussion; however, it remains unclear whether concussion-related miRNAs are impacted by exercise. We sought to determine whether 40 miRNAs previously implicated in concussion pathophysiology were affected by participation in a variety of contact and non-contact sports. Our goal was to refine a miRNA-based tool capable of identifying athletes with SRC without the confounding effects of exercise.

Methods

This case-control study harmonized …

Pandemic Review: South Los Angeles, Madeline Carmella Acosta

Whittier Scholars Program

IMPORTANCE The COVID-19 pandemic has deepened the discussion on social inequality and vulnerabilities of the Black, Indigenous, and People of Color (BIPOC) community. The understanding is that inequality is a multifaceted issue that stems from the historical mistreatment of BIPOC individuals—their sociodemographic and economic backgrounds are at the most risk in population studies. Many predictors of contracting COVID-19 included employment status (ability to work from home), education level, income (wealth), and housing conditions (environment) (Rozenfeld et al., 2020). Contracting COVID-19 in South Los Angeles was more likely to happen among those from racial and ethnic minorities and those living in …

The Importance Of Mood And Motivation Of An Individual In The Success Of Physical Therapy, Spencer Wagner

Honors Program: Senior Projects (Public)

Physical therapy is a health profession that helps people improve their movement and range of motion in certain body areas. Since the time it was founded, physical therapists have mainly focused on the physical health of the patient. While that is their job, they may not have been as successful because they neglected the mental health of the patient. The mindset of an individual, particularly their mood and motivation, can influence how they progress through physical therapy and how successful they are in regaining functionality in their affected body area. The purpose of this study is to determine how the …

Synthetic Or Not: Implications Of Hormonal Birth Control On Women’S Hormones And The Cortisol Stress Response, Maddie Perry '23

Honor Scholar Theses

Women’s bodies are the subject of decision-making and control, yet women’s lives are dismally ignored. The field of women’s health is highly understudied, and the demand for that adequate research must be granted to the women’s health field. This interdisciplinary research study investigated stress response differences between hormonal birth control users and non-users. Hormonal birth control (HBC) is one of the greatest technologies afforded to women and further research is necessary to ensure women are guaranteed bodily autonomy and women’s health education. Due to altered hormonal signaling, HBC has been linked to behavioral and decision making differences in women. Building …