Medicine and Health Sciences Commons^™

An Analysis Of Trends Of Generic Drugs And Biologic Prices In The U.S., Mohammed Jamjoom

Pharmaceutical Sciences (PhD) Dissertations

Introduction: Drug prices are a significant problem for the US healthcare system. Generic and biosimilar market competition reduces drug and biologic prices, results in substantial savings, and improves patient access and outcomes. As the costs of healthcare and prescription drugs continue to rise, the discussion about drug prices has taken a prominent place at the forefront of national discourse. This study assessed impacting trends in prices of generic, biosimilar, and reference products in the US. We also evaluated the effect of the Affordable Care Act (ACA) of 2010 on biologic prices.

Methods: We extracted a list of the new generic …

The Role Of Cytochrome P450 2e1 In Hepatic Ischemia Reperfusion Injury And Reactive Oxygen Species Formation, Nouf Alwadei

Pharmaceutical Sciences (PhD) Dissertations

The mechanisms of hepatic ischemia/reperfusion (I/R) injury, which occurs during liver transplantation or surgery, are poorly understood. The central pathophysiological phenomenon of this injury is the formation of reactive oxygen species (ROS). Recent studies suggest that P450 enzymes may contribute to ROS generation, which may occur through their uncoupling and/or release of heme and iron after their degradation. Among P450 enzymes, CYP2E1 is unique because it is considered a leaky enzyme, producing significant ROS through uncoupling in the absence of substrates, accelerating its own degradation and reducing its half-life. In this dissertation, we generated and characterized a HepG2 cell line …

An Investigation Of Resistance Training Behavior, Non-Specific Psychological Distress, And Perceived Barriers To Resistance Training In Self-Identifying Female Undergraduate Students, Jody Sobel

Master's Theses

The prevalence and severity of depression symptoms amongst college students, specifically female identifying undergraduate students, is worrisome. There is a great deal of research that suggests a relationship between exercise, specifically resistance training (RT), and mental health. That said, current literature suggests that many female identifying students are not engaging due to perceived barriers. This, perhaps because of the plethora of barriers one can perceive. The purpose of this study was multifold 1) to examine the prevalence and severity of non-specific psychological distress; 2) to determine if there were differences between Kessler 6 Non-Specific Psychological Distress Scale (K6) categories (i.e., …

An Examination Of The Legal Responses By United States To Technological Advances In Organized Drug Smuggling, Abdulwahab Aldossary

University Honors Program

Recent advances in technology have aided terrorists in their ability to smuggle drugs in order to finance their operations. Drug trading routes have changed and so have methods of transportation and financial transaction. This study investigates the improved technology utilized by transnational organized crime groups and how the present laws and policies address the use of the improved technology for drug smuggling. The study will first look into the current models, such as the Counter-Terrorist Funding and Money Laundering model, and understand its weaknesses regarding drug smuggling within the United States. Moreover, the paper will focus on the current laws …

Canine Heartworm Infection And Prophylaxis Use Among Pet Caretakers From The Cumberland Gap Region Of Tennessee, Usa, Charles T. Faulkner

Faculty Other Scholarly Content

The prevalence of infection with canine heartworm (CHW), Dirofilaria immitis, continues to increase across the United States, regardless of the availability of effective and affordable prophylactic products. Current reports of CHW prevalence as estimated by the Companion Animal Parasite Council (CAPC) are thought to under-represent the true magnitude of the issue because pet dogs that do not receive regular veterinary care are often excluded. This study estimated the prevalence of CHW in pet dogs and associated prophylaxis use in pet dogs in the Cumberland Gap Region with a combined doorstep diagnostic testing approach and caretaker survey. Dogs tested (n = …

Himmelfarb Library Liaison Letter - May 2023, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

The Effects Of Sound-Based Intervention On The Daily Performance Of College-Aged Students, Claire Pribble

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

A mixed-methods summary examining the effects of The Listening Program (TLP) on the daily performance of a graduate student is presented. This is a pilot study that will observe the impacts of this program and the possible improvements in focus, visual perception, time management, behavior, and emotional and social regulation. Improvements in self-control/belief and overall stress management were noted.

This case study focuses on one college-aged individual who is successfully and independently managing her graduate experience, receives no accommodations for disability, and has no previous experience with The Listening Program. Self-reports indicated high levels of intermittent stress and anxiety which …

Measuring Awareness Of Spd And Interprofessional Collaboration And Practices Among Professionals In An Elementary Public School Setting, Kyra Resende

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Sensory Processing Disorder (SPD) is a neurological condition in which the brain has trouble receiving and responding to sensory information, which can lead to sensory dysregulation (Rodden, 2023). Because everyone constantly receives sensory input, having SPD can impact a child’s life in numerous ways, such as academic and social success. Research indicates that 5% to 16% of students may have this neurological condition (Bunim, 2013), which is significant enough to expect that school professionals have appropriate awareness about SPD. Additionally, there is usually an overlap of professionals who serve students experiencing SPD, resulting in a need for interprofessional collaboration (IPC) …

University Campus Breastfeeding, Knowledge, And Perceptions Of Support: An Exploratory Study, Allison L. Scott, Ann W. Lambert, Chih-Hsuan Wang, Kelly V. Johnson, Jessica Weiss, Tony Stankus

The Eleanor Mann School of Nursing Faculty Publications and Presentations

Breastfeeding is often considered principally a biological issue but success is impacted by the socio-ecological environment of the lactating parent. Identifying current attitudes towards breastfeeding is essential in the effort toward normalizing breastfeeding in communities, including university campuses. The study explored campus community knowledge, awareness, and attitudes about breastfeeding, including available resources and applicable laws on two university campuses in the southern United States. This cross-sectional, self-reporting study utilized the Iowa Infant Feeding Attitude Scale and an adaptation of the Breastfeeding Behavior Questionnaire to survey a convenience sample. Results revealed decreased awareness of protective laws, availability of private lactation space, …

Associations Between Technology Use, Responsive Feeding, And Child Temperament Among Prior Prenatal Intervention Participants, Alison K. Ventura, Chantelle N. Hart, Suzanne Phelan, Elissa Jelalian

Kinesiology and Public Health

Objectives: The primary objective was to examine associations between mothers’ television and mobile device (TV/MD) use and responsive feeding during an observed mother-toddler mealtime interaction. The secondary objective was to assess whether dimensions of child temperament were associated with mothers’ TV/MD use. Methods: Participants from a prenatal lifestyle intervention trial to prevent excess gestational weight gain among women with overweight and obesity (N 5 77) were observed during a dinnertime meal when their children were aged 19.4 6 0.9 months. Trained video coders used the Responsiveness to Child Feeding Cues Scale to rate child strength of early/subtle, positive active, and …

Immunomodulatory Effects Of Resolvin D2 In A Model Of Infection, Prem Yugandhar Kadiyam Sundarasivarao

Graduate School of Biomedical Sciences Theses and Dissertations

Dysregulated hyperinflammatory host immune response to underlying bacterial infections is a characteristic of sepsis. In sepsis, bacteria often trigger abnormal hyperinflammatory responses which can cause multiple organ failure and if sustained can lead to an immunosuppressive phase where the host is susceptible to secondary infections caused by opportunistic bacteria like Pseudomonas aeruginosa (P. aeruginosa). In our studies, we used a 2-hit model of cecal ligation and puncture (CLP) followed by P. aeruginosa secondary lung infection to investigate cellular and molecular mechanisms in the beneficial action of resolvin D2 (RvD2). Resolvins of the D-series are a group of fatty acids known …

Functional Movement Screen: Exploring Interrater Reliability Between Students, Austin Weisz, Lindsey Knoll, Emily Schuster, Cooper Tietz

Physical Therapy Scholarly Projects

Purpose: The purpose of this study was to assess the interrater reliability of the most recent Functional Movement Screen (FMS), between four second-year physical therapy students. The most recent FMS has added the ankle clearing test (pain and mobility categories) after the inline lunge and modified the rotary stability movement pattern and criteria for scoring. To our knowledge, there has not been a reliability study completed with the most recent additions and modifications of the FMS.

Methods: Forty-five physical therapy students participated and were videotaped completing the Functional Movement Screen (FMS) and were rated by four current second-year physical …

Physical Therapy Clinical Instructor's Viewpoints On Entry-Level Performance Of Physical Therapy Students And New Graduates, Elhana Selimovie

Physical Therapy Scholarly Projects

Purpose: The purpose of this study was to gain perspective on how physical therapy clinical instructors (CI) define entry-level in relation to the field of physical therapy. The research question asked CIs was whether or not there was a difference in how CIs defined entry-level physical therapists. Entry level is defined as “a student who is capable of functioning without guidance or supervision while managing simple or complex conditions, with proficiency in skilled examinations, interventions, and clinical reasoning, and is able to maintain 100% of a full-time therapist’s caseload in a cost-effective manner.”

Methods: A survey was sent …

The Progression, Treatment, And Rehabilitation Of Guillain Barré Syndrome: Case Report, Hannah M. Shaffer

Physical Therapy Scholarly Projects

Background and Purpose: Guillain Barré Syndrome (GBS) is an acute demyelinating disease of the peripheral nervous system. It is characterized by sudden progressive weakness and paraesthesias of the limbs. This case study evaluates the effectiveness of physical therapy (PT) and the use of body-weight support gait training (BWST) in the return to function in GBS patients.

Case Description: The patient was a 42-year-old female who presented to the acute care hospital with sudden onset paresthesias and weakness causing sudden loss of ambulation and functional mobility.

Interventions: Due to decreased activity tolerance, initial PT treatment consisted of passive …

The Effects Of Physical Therapy For Acute Knee Pain With Meniscuc Involvement: A Case Report, Courtney R. Hornung

Physical Therapy Scholarly Projects

Introduction: Cartilage tears and osteoarthritis are upon the most common sources of knee pain. The peak incidence for degenerative meniscal tears in women are from ages 61-70. The meniscus acts as a cushion within the knee and if this becomes damaged or degenerates over time, osteoarthritis is likely to become a factor as well. The purpose of this study is to find whether or not physical therapy is an appropriate treatment option for a patient with knee pain with indications of osteoarthritis and a meniscal involvement.

Case Description: The patient is an 82 year old female who came …

The Effects Of Palmar Cooling On Power, Strength, And Endurance: An Investigative Study, Madison Kramer

Physical Therapy Scholarly Projects

Purpose/Hypothesis: For many athletes and active individuals, the ability to improve endurance, strength, and power is a common goal. Millions of people around the world engage in sporting events and other physical activities every day. While each sport has differing physical requirements, each sport requires varying degrees of endurance, strength, and power. During sporting events or exercise routines, body temperature increases and eventually begins to have a negative impact on performance. Research on palmar cooling has shown endurance benefits. The palm is an area of the body with abundant anastomoses, or cross-connections of blood vessels. These areas transfer heat …

Social Support And Perceptions Of Covid-19-Related Emotional Impact On Mental Health Among Early Adolescents In Appalachia, Hannah M. Layman, Michael J. Mann, Megan L. Smith, Steven M. Kogan, Alfgeir L. Kristjansson

Public and Population Health Faculty Publications and Presentations

Background: Young people who experience higher levels of social support from their schools and families have been shown to be less likely to develop symptoms of negative mental health outcomes such as depression and anxiety.1–4 This raises questions concerning how young people's stress and psychological changes due to the COVID-19 pandemic as well as social support during this time have affected their overall mental health. The aim of this study was to assess the association between sources of parental- and school-level social support and youth perceptions of COVID-19-related emotional impact on mental health among early adolescent girls and boys in …

Quantifying The Effect Of Socio-Economic Predictors And The Built Environment On Mental Health Events In Little Rock, Ar, Alfieri Ek, Grant Drawve, Samantha Robinson, Jyotishka Datta

Sociology and Criminology Faculty Publications and Presentations

Law enforcement agencies continue to grow in the use of spatial analysis to assist in identifying patterns of outcomes. Despite the critical nature of proper resource allocation for mental health incidents, there has been little progress in statistical modeling of the geo-spatial nature of mental health events in Little Rock, Arkansas. In this article, we provide insights into the spatial nature of mental health data from Little Rock, Arkansas between 2015 and 2018, under a supervised spatial modeling framework. We provide evidence of spatial clustering and identify the important features influencing such heterogeneity via a spatially informed hierarchy of generalized …

The Effect Of Weight Bias On The Prevalence Of Cardiovascular Disease, Manuela Paki Amouzou

Undergraduate Theses and Capstone Projects

The condition of obesity has been recognized by the American Medical Association (AMA) as a multi-faceted chronic disease. Previous studies have shown an associational relationship between recorded weight bias in healthcare providers, in society at large, andtowards oneself and negative health outcomes. In addition, the increased rate of recorded obesity is often tied to the increased incidence of cardiovascular disease in the population. Therefore, it is imperative to discuss the causes of this relationship and an updated course of treatment. The purpose of this study is to evaluate how the attitudes and beliefs of healthcare providers towards people who are …

Prefrontal Activation During Inhibition Of A Balance Recovery Step, Ezinne Abugu

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The ability to quickly step is an important strategy to avoid a fall. However, real-world settings often constrain a stepping path. Such constraints necessitate response inhibition to prevent an inappropriate step and select a new course of action to ultimately recover balance. The present study investigated neural mechanisms that underlie this ability to stop a highly automatic balance recovery step. In the field of cognitive neuroscience, response inhibition has typically been researched using focal hand reaction tasks performed by seated participants. This approach combined with neuroimaging has revealed a neural stopping network, which includes the right Inferior Frontal Gyrus (right …

The Effect Of Exercise Interventions On Cognitive Functions In Individuals With Down Syndrome: A Systematic Review Of The Literature, Emma Moreland

Masters Theses & Specialist Projects

Purpose: Previous research showed that exercise positively impacts cognition, specifically executive functioning. This systematic review aims to determine the impact of exercise on cognitive functions in people with Down Syndrome.

Method: A systematic review of the research literature related to the influence of exercise on cognition for individuals with Down syndrome was carried out. Included studies were evaluated for level of evidence and appraised for strength of study design. Post-intervention change score differences between groups were analyzed using effect sizes (Hedge’s g).

Results: Fifteen intervention studies met inclusionary criteria and were included in the systematic review. Levels of evidence for …

An Improvement Science Approach To Understanding Adaptive Leadership As A Tool For Diabetes Educators To Teach Patient Self-Efficacy, Allie Carter

Dissertations

Background: Worldwide diabetes is estimated at 415 million, and that number is expected to increase to 642 million by 2040 (Roberts et al., 2017). Certified Diabetes Care and Educational Specialists (CDCES) and other health care providers strive to teach patients with diabetes skills that assist them in developing and maintaining self-efficacy. Current education methods are not always enough to help a patient navigate effects of their diabetes. Using the adaptive leadership principles can provide educators an interventional practice that facilitates patient self-management. This study explores the effectiveness of adaptive leadership when applied to the diabetes education delivery and confirms the …

Qualitative Development Of Items For A Young Adult Autism Spectrum Disorder Screener, David Roehm

Masters Theses & Specialist Projects

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits across multiple domains such as deficits in social communication and restricted, repetitive patterns of behavior. The prevalence of ASD has increased over time, and while there are ample screeners and assessments for children, there is a distinct lack of screeners for young adults between the ages of 18 and 25 years. The present study focused on exploring the gap in screeners for ASD in young adults and assessing the insight of experts in the field toward the development of a screener for ASD in young adults. Participants (N = …

Women’S Pornography Use And Sexuality Education In U.S. Public Schools, Julie Fraumeni-Mcbride

Education (PhD) Dissertations

The relationship between sexuality education and self-reported pornography use is not well understood in the context of public policy and education. Little is known about women’s pornography use and the effects such exposure could have on female sexuality and well-being; therefore, this study sought to fill that gap. This study broadly examined the relationship between sexuality education in U.S. public schools and women’s pornography use to provide recommendations for future research and public policy. To do this, quantitative methods (i.e., Welch’s t tests for hypothesis testing and ANCOVAs for covariate elimination) were used in a sample of women who attended …

Outcomes Of The "Brca Quality Improvement Dissemination Program": An Initiative To Improve Patient Receipt Of Cancer Genetics Services At Five Health Systems., Erica M Bednar, Minxing Chen, Michael T Walsh, Amanda L Eppolito, Molly H Klein, Kelly Teed, Brittany Hodge, Jordan Hunter, Han Gill Chao, Dillon Davis, Wilshauna Serchion, Cara Yobbi, Rebekah Krukenberg, Sandra B Jenkinson, Jennifer J Moore, Cassandra Garcia, Fatimaeliza Gonzalez, Towanna Murray, Linda D Nielsen, Brenda Ho, Megan Haas, Sarah B Greenzweig, Abby Anderson, Christina Johnson, Nichole A Morman, Elizabeth Bowdish, Emaline Wise, Julia N Cooper, Pauline Kefalas Russ, Katelyn Tondo-Steele, Buonarotti F De Gracia, Brooke Levin, Kristin Mattie, Kathryn Zarnawski, Molly Kalasinski, Jennifer Stone, Caitlin O'Brien, Alexa Bream, Aidan M Kennedy, Rachel A Paul, Michelle Bilbao, Maureen Romero, Rebecca L Carr, Jennifer M Siettmann, Anna K Vercruyssen, Kaycee Leon, Banu K Arun, Andrew V Grainger, David P Warshal, Erin Bowman, Timothy A Goedde, Deepa Halaharvi, Kellie Rath, Generosa Grana, Lida Mina, Karen H Lu

Oncology Articles

OBJECTIVE: A quality improvement initiative (QII) was conducted with five community-based health systems' oncology care centers (sites A-E). The QII aimed to increase referrals, genetic counseling (GC), and germline genetic testing (GT) for patients with ovarian cancer (OC) and triple-negative breast cancer (TNBC).

METHODS: QII activities occurred at sites over several years, all concluding by December 2020. Medical records of patients with OC and TNBC were reviewed, and rates of referral, GC, and GT of patients diagnosed during the 2 years before the QII were compared to those diagnosed during the QII. Outcomes were analyzed using descriptive statistics, two-sample t-test, …

Inner Portraits, Bethany Salisbury

Graduate Theses

This paper investigates the many interconnected layers of women’s mental health through portraiture and how animal and plant symbolism can represent the way women's hormones and bodily health affect their mental health. I reveal how the artwork created presents these connections and inner mental health narratives to the viewer, creating a space of empathy, destigmatization, and self-reflection. This body of portraiture art connects five women through a series of both two-and three-dimensional portraits based on interviews using my own adaptation of Sara Lawrence-Lightfoots’ (1983) portrait methodology.

Women and non-binary individuals have always dealt with difficult interactions of bodily and mental …

The Relationship Between Communicative Confidence And Identity In Everyday Life For People With Aphasia, Karina Escobar

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Aphasia is primarily a neurological language disorder, which can also affect cognition, attention, and executive functioning skills. In recent years, researcher has taken an interest in understanding quality of life for people with aphasia, specifically communicative confidence, social relationships, and identity. The aim of this study was to determine how communicative confidence and social relationships affect a person’s identity, as well as the importance of therapy groups. We designed and used confidence and independence survey scales pre-aphasia, post-aphasia but before attending aphasia therapy groups, and post-aphasia and after having attended aphasia therapy groups. We also asked clarifying questions based on …

Integrating Ebm And The Basic Sciences - A Valuable Medical School Assignment, Deborah A. Crooke, Elizabeth D. Drugge

NYMC Faculty Posters

No abstract provided.

Bronchiolitis: Albuterol Use, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

The Efficacy Of Neuroleptics On Mental Health Disorders, Rathea Hersi

Honor’s College Freeman Research Journal

Mental health disorders affect a lot of people in the world and can be triggered by a wide variety of reasons. The treatment of mental health disorders varies based on the type of disorder one is dealing with, as well as the symptoms that each portrays. While history has changed how people view mental health disorders, it also shows that the models of treatment used have not always been beneficial to the wellness of human beings. Research shows that there are different ways in which mental health disorders affect the brain, which means that a study of the different parts …