Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 7891 - 7920 of 324910

Full-Text Articles in Medicine and Health Sciences

Indian Standard For Alfalfa (Medicago Sativa L.), Kumar Vivekanand, Daisy Katarmal, Indra Gaurav Saxena, Binit Dwivedi, Divya Taneja, Shrishti Dixit, Raj Kumar Manchanda Mar 2026

Indian Standard For Alfalfa (Medicago Sativa L.), Kumar Vivekanand, Daisy Katarmal, Indra Gaurav Saxena, Binit Dwivedi, Divya Taneja, Shrishti Dixit, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

Traditional systems of medicine remain integral to global healthcare, yet variability in herbal raw materials has long challenged their scientific validation and regulatory acceptance. Differences in environmental conditions, harvesting, processing and formulation techniques significantly influence the herb's phytochemical composition, potency, and therapeutic outcomes. Standardisation is therefore essential to ensure safety, efficacy, reproducibility, and regulatory credibility. In this context, the Bureau of Indian Standards (BIS) has developed Indian Standards for medicinal plants and homoeopathic preparations. This article presents an overview of IS 18978:2024, Alfalfa (Medicago sativa L.) for Use in Traditional Medicine—Specification, and IS 19135:2025, Alfalfa Hydro-alcoholic Extract for Use …


Fundamental Research Principles In Homoeopathy: Bridging Empirical And Clinical Evidence, Himanshu Shekhar, Parth Aphale, Shashank Dokania Mar 2026

Fundamental Research Principles In Homoeopathy: Bridging Empirical And Clinical Evidence, Himanshu Shekhar, Parth Aphale, Shashank Dokania

Indian Journal of Research in Homoeopathy

Letter to Editor


Comparative Analysis Of Clearing Methods For 3d Imaging Of The Vasculature In Mineralized Mouse Tissues, Azeez O Ishola, Athira Pillai, Taeyong Ahn, Re-Join Consortium, Chih-Wei Hsu, Brendan Lee, Nele Haelterman, Joshua D Wythe Mar 2026

Comparative Analysis Of Clearing Methods For 3d Imaging Of The Vasculature In Mineralized Mouse Tissues, Azeez O Ishola, Athira Pillai, Taeyong Ahn, Re-Join Consortium, Chih-Wei Hsu, Brendan Lee, Nele Haelterman, Joshua D Wythe

Faculty, Staff and Students Publications

Historically, visualization of vascular networks within the musculoskeletal system, particularly in mineralized tissues such as bones and joints, has been limited to conventional 2D histological approaches. Recent advances in optical tissue clearing technologies and fluorescence imaging approaches in whole, intact tissues offer an entrée to interrogate the vasculature at unprecedented resolution during both musculoskeletal development and in pathologic contexts in three dimensions. However, these clearing techniques were originally not developed for imaging hard mineralized tissues, such as the femur and tibia. Herein, we have optimized tissue decalcification conditions and compared aqueous- and solvent-based tissue clearing approaches to establish an optimal …


Translating Multi-Omics Into Healthcare: Requisites For Scalable And Equitable Implementation, Birute Tumiene, David R Adams, Robert Allaway, Maria J Barrero, Chun-Hung Chan, Víctor Faundes, Vanessa S Fear, Polina Glezer, Claudia Fuchs, Tudor Groza, Elisa J F Houwink, Saumya Shekhar Jamuar, Mary Catherine V Letinturier, Richa Madan Lomash, Ratna Dua Puri, Juergen K V Reichardt, Ruty Mehrian-Shai, Francois H Van Der Westhuizen, Gaurav K Varshney, Shinya Yamamoto, Gareth Baynam Mar 2026

Translating Multi-Omics Into Healthcare: Requisites For Scalable And Equitable Implementation, Birute Tumiene, David R Adams, Robert Allaway, Maria J Barrero, Chun-Hung Chan, Víctor Faundes, Vanessa S Fear, Polina Glezer, Claudia Fuchs, Tudor Groza, Elisa J F Houwink, Saumya Shekhar Jamuar, Mary Catherine V Letinturier, Richa Madan Lomash, Ratna Dua Puri, Juergen K V Reichardt, Ruty Mehrian-Shai, Francois H Van Der Westhuizen, Gaurav K Varshney, Shinya Yamamoto, Gareth Baynam

Faculty, Staff and Students Publications

Multi-omics in combination with advanced computational methodologies synthesizes diverse omics data to provide deeper insights into molecular interactions and offers transformative potential for unravelling phenomenon behind disease complexities, improving diagnostics, disease prevention, and personalized treatments. This integrative strategy enables our understanding of gene-environment relationships, chronic disease progression, and the intricate molecular pathways involved in health. Effective multi-omics analyses require robust data sharing, accessibility, interoperability, and governance, which are critical for linking genomic elements to phenotypic traits. The Global Alliance for Genomics and Health advocates for responsible data-sharing practices, by promoting key principles such as transparency and equity. By emphasizing a …


Incidence Of Autoimmune Diseases In Children With Atopy Treated With Dupilumab, Stanislaw J Gabryszewski, Kathryn Hirabayashi, Morgan Botdorf, Mitchell Maltenfort, Christopher B Forrest, Theresa W Guilbert, Madeline Schutt, Hiroki Morizono, Gerardo Vazquez Garcia, Anna Cristina Garza-Mayers, Joseph Demetrius Hernandez, Sara Anvari, Suchitra Rao, Jonathan M Spergel Mar 2026

Incidence Of Autoimmune Diseases In Children With Atopy Treated With Dupilumab, Stanislaw J Gabryszewski, Kathryn Hirabayashi, Morgan Botdorf, Mitchell Maltenfort, Christopher B Forrest, Theresa W Guilbert, Madeline Schutt, Hiroki Morizono, Gerardo Vazquez Garcia, Anna Cristina Garza-Mayers, Joseph Demetrius Hernandez, Sara Anvari, Suchitra Rao, Jonathan M Spergel

Faculty, Staff and Students Publications

Background: The type 2 inflammation-blocking agent dupilumab has gained traction as an effective treatment of multiple atopic diseases. New-onset autoimmune manifestations have been infrequently reported in dupilumab-treated atopic patients, primarily among adults. Autoimmune outcomes in atopic children on dupilumab are less clear.

Objective: We aimed to determine if dupilumab treatment of atopic children is associated with increased autoimmune or autoinflammatory disease diagnosis risk.

Methods: Using a multi-institutional electronic health record database composed of 10 PEDSnet academic health systems, we performed a retrospective cohort study of children aged 6-17 with atopy (ie, moderate-to-severe atopic dermatitis and/or persistent asthma, as defined by …


Net Benefit Of Surveillance Varies By Hepatocellular Carcinoma Risk In Patients With Cirrhosis, Akash Patel, Elena Gavrila, Sruthi Yekkaluri, Yujin Hoshida, Ruben Hernaez, Amit G Singal Mar 2026

Net Benefit Of Surveillance Varies By Hepatocellular Carcinoma Risk In Patients With Cirrhosis, Akash Patel, Elena Gavrila, Sruthi Yekkaluri, Yujin Hoshida, Ruben Hernaez, Amit G Singal

Faculty, Staff and Students Publications

Background: The risk of hepatocellular carcinoma (HCC) and net benefit of surveillance may differ between patients with cirrhosis. We compared the benefits and harms of HCC surveillance across risk strata in patients with cirrhosis.

Methods: We leveraged a cohort of patients with cirrhosis from a pragmatic RCT of HCC surveillance outreach enrolled between March 2018 and April 2021. Patients were stratified into low-, intermediate-, and high-risk categories based on published thresholds for three validated clinical risk scores. We calculated HCC incidence rates and moderate-to-severe physical harms for each risk stratum.

Results: Of 2142 patients with cirrhosis followed for a median …


Residual Risk Of Hyperkalemia Among Patients With Heart Failure Treated With Both Sglt2i And Arni, Stephen J Greene, Shachi Patel, Khaja Chinnakondepalli, Stefan D Anker, Michael Böhm, Biykem Bozkurt, Javed Butler, John Gf Cleland, Andrew J Coats, Nihar Desai, Victoria Donachie, Ellie Kelepouris, Giuseppe Rosano, Carla-Maria Brandes, Andrew J Sauer Mar 2026

Residual Risk Of Hyperkalemia Among Patients With Heart Failure Treated With Both Sglt2i And Arni, Stephen J Greene, Shachi Patel, Khaja Chinnakondepalli, Stefan D Anker, Michael Böhm, Biykem Bozkurt, Javed Butler, John Gf Cleland, Andrew J Coats, Nihar Desai, Victoria Donachie, Ellie Kelepouris, Giuseppe Rosano, Carla-Maria Brandes, Andrew J Sauer

Faculty, Staff and Students Publications

No abstract provided.


K2p Channels As Key Regulators Of Cardiovascular And Pulmonary Vascular Function, Hala Y Abdelnasser, Xinchun Pi, Lavannya M Pandit, Bradley K Mcconnell Mar 2026

K2p Channels As Key Regulators Of Cardiovascular And Pulmonary Vascular Function, Hala Y Abdelnasser, Xinchun Pi, Lavannya M Pandit, Bradley K Mcconnell

Faculty, Staff and Students Publications

Two-pore domain potassium (K2P) channels are the most recently identified family of potassium channels. They are regarded as the largest group of background “leak” channels, encoded by 15 mammalian KCNK genes, and divided into six subfamilies (TWIK, TREK, TASK, TALK, THIK, and TRESK). These channels have a role in stabilizing the resting membrane potential. Their widespread presence in the heart and vasculature supports cellular homeostasis by regulating cardiac rhythm, vascular tone, and protection against ischemic stress. The TASK, TWIK, and TREK subfamilies are the most abundantly expressed K2P channel subfamilies in the cardiovascular system, and dysregulation of specific members has …


Evaluation Of Nurses' Leadership Self-Efficacy In Belize, Ruth Rosalee Reina Jones Mar 2026

Evaluation Of Nurses' Leadership Self-Efficacy In Belize, Ruth Rosalee Reina Jones

Walden Dissertations and Doctoral Studies

Nursing leadership in Belize is lacking but crucial to the well-being of patients, families, and the healthcare team. The purpose of this non-experimental, descriptive, comparative study was to a) determine the difference in leadership self-efficacy for current nurse leaders with three years or less of leadership experience compared to current nurse leaders with more than three years of leadership experience in Belize, and b) examine the differences in leadership self-efficacy between nurses in a leadership position and nurses not in a leadership position in Belize. The theories supporting the study were Burns’ transformational leadership theory and leadership self-efficacy, based on …


Fasting-Based Dietary Interventions In Cancer Patients And Survivors: A Scoping Review, Kuang-Yi Wen, Julianne Freedman, Abenezer Melaku Tafese, William Kevin Kelly, Nicole L Simone Mar 2026

Fasting-Based Dietary Interventions In Cancer Patients And Survivors: A Scoping Review, Kuang-Yi Wen, Julianne Freedman, Abenezer Melaku Tafese, William Kevin Kelly, Nicole L Simone

Department of Medical Oncology Faculty Papers

Background: Fasting-based interventions are increasingly investigated as adjuncts to cancer treatment for the potential to reduce therapy-related toxicities, improve metabolic health, and enhance quality of life. However, clinical evidence regarding their efficacy, tolerability, and acceptability remains limited and fragmented. This scoping review aimed to systematically map the current evidence on fasting-based interventions in cancer patients and survivors.

Methods: A literature search was conducted in PubMed, Scopus, Web of Science, and CINAHL up to 10 June 2025. Eligible interventional studies included cancer patients or survivors and evaluated fasting-based interventions, such as time-restricted eating, intermittent fasting, short-term fasting, or fasting-mimicking …


Multi-Modal Tensor Fusion For Alzheimer’S Disease Recognition, Mason Li, Tiffany Le, Jiajing Huang, Yuxin Wen Mar 2026

Multi-Modal Tensor Fusion For Alzheimer’S Disease Recognition, Mason Li, Tiffany Le, Jiajing Huang, Yuxin Wen

Engineering Faculty Articles and Research

Accurate and early diagnosis of Alzheimer’s disease (AD) is critical for effective intervention, disease monitoring, and patient care. Traditional diagnostic approaches rely on a single modality, such as clinical assessments, neuroimaging, or genetic markers, which may fail to capture the complex, multifaceted nature of AD. Multimodal learning has therefore been explored to integrate complementary information across data sources. However, conventional fusion strategies, including early feature concatenation and late decision-level fusion, often model modalities independently and fail to capture high-order cross-modal interactions. To address these limitations, we propose a multimodal tensor fusion network (MTFN) that integrates heterogeneous data sources, including visual …


Efficacy Of Individualised Homoeopathic Medicines As An Adjunct To Conventional Iron And Folic-Acid Supplementation In Iron Deficiency Anaemia Among Reproductive-Aged Women: Single-Blind, Randomised, Placebo-Controlled Trial, Avidipta Hazra, Tanmay Sarkar, Debarsi Das, Rakesh Ghosh, Chandrani Ghosh Mar 2026

Efficacy Of Individualised Homoeopathic Medicines As An Adjunct To Conventional Iron And Folic-Acid Supplementation In Iron Deficiency Anaemia Among Reproductive-Aged Women: Single-Blind, Randomised, Placebo-Controlled Trial, Avidipta Hazra, Tanmay Sarkar, Debarsi Das, Rakesh Ghosh, Chandrani Ghosh

Indian Journal of Research in Homoeopathy

Background: Iron deficiency anaemia (IDA) is a major public health concern affecting women of reproductive age globally. If left untreated, it can cause various health issues including fatigue, shortness of breath, abnormal heart rhythms, chest pain, and complications during pregnancy. Objectives: To evaluate the efficacy of individualised homoeopathic medicines (IHMs) with iron and folic acid supplement (IFS) in treatment of iron deficiency among reproductive-aged women, in comparison with placebos with IFS. Methods: Single-blind, randomised, placebo-controlled clinical trial was conducted over total six months at the outpatient-department, of which participants received interventions and outcome assessments for three months. Reproductive women (15–49 …


Engagement Patterns With #Naturalremedies On Tiktok: Formative Analysis, Apeksha Mewani, Corey H. Basch, Keanu Renne-Glover, Vincent Jones Ii, Cristiana Cordero, Adea Gutiqi Mar 2026

Engagement Patterns With #Naturalremedies On Tiktok: Formative Analysis, Apeksha Mewani, Corey H. Basch, Keanu Renne-Glover, Vincent Jones Ii, Cristiana Cordero, Adea Gutiqi

Publications and Research

This research letter provides formative evidence from a cross-sectional analysis of 118 TikTok videos under #NaturalRemedies, identifying content formats and expertise cues associated with higher engagement, while also demonstrating the feasibility of using engagement metrics and thematic coding to analyze health narratives on emerging platforms such as TikTok.


Mdm4 At The Crossroads: Beyond P53 And Mdm2., Dipesh Thapa, Allison St John, Alejandro Parrales, Atul Ranjan, Tomoo Iwakuma Mar 2026

Mdm4 At The Crossroads: Beyond P53 And Mdm2., Dipesh Thapa, Allison St John, Alejandro Parrales, Atul Ranjan, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

MDM4 (Murine Double Minute 4), also known as MDMX, is a crucial negative regulator of the tumor suppressor p53. MDM4 heterodimerizes with MDM2 to enhance MDM2-mediated ubiquitination and degradation of p53, thereby promoting tumorigenesis. Beyond its canonical role in inhibiting p53 activity, recent studies have revealed diverse p53-independent functions. MDM4 interacts with various proteins, including p73, E2F1, casein kinase 1α, PPARα, and TRIM21 to regulate cell cycle progression, β-catenin-mediated pre-leukemic progression, and ferroptosis independent of p53. In addition, MDM4 functions independently of both p53 and MDM2 by interacting with proteins, such as SMAD family members 3/4, retinoblastoma protein (pRB), p21, …


Mitochondrial Transfer And Induced Ros As A Therapeutic Strategy In Idh2-Mutant Chondrosarcoma, Vegas R. Bedder, Caleb Wyckoff, Chris Osgood, Gavin A. Vasquez, Michael Stacey Mar 2026

Mitochondrial Transfer And Induced Ros As A Therapeutic Strategy In Idh2-Mutant Chondrosarcoma, Vegas R. Bedder, Caleb Wyckoff, Chris Osgood, Gavin A. Vasquez, Michael Stacey

Knowledge and Creativity Expo

Chondrosarcoma (CS) are common bone cancers that produce cartilaginous tumors and are extremely refractive to chemo-and-radiation therapies, leaving very limited treatment options. They contain mutations in the isocitrate dehydrogenase genes, IDH1 or IDH2. Either IDH1 or IDH2 mutations are present in individual tumors, but not both. They both convert alphaketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG). D2HG can be transported from the tumors to cells of the tumor microenvironment (TME) where it can alter metabolic and epigenetic profiles in recipient cells. The process of α-KG to D2HG conversion occurs in the cytoplasm of IDH1 mutant cells, and in the …


Craniofacial Differences And Safe Sleep Practices: Findings From A Caregiver Survey At A Children’S Hospital, Cait Vuturo-Brady, Aracelia S. Aldrete, Jesus Gil Inciong, Miccah Seaman, Rianna Leazer Mar 2026

Craniofacial Differences And Safe Sleep Practices: Findings From A Caregiver Survey At A Children’S Hospital, Cait Vuturo-Brady, Aracelia S. Aldrete, Jesus Gil Inciong, Miccah Seaman, Rianna Leazer

Knowledge and Creativity Expo

Purpose

Many infants with cleft lip and/or palate (CL/P) have airway issues that make supine, flat-surface sleep challenging.1 Prior studies indicate that alternative positioning may reduce obstructive events,2 and early sleep-disordered breathing can affect later development.3  Despite this, caregivers of infants with craniofacial differences rarely receive tailored sleep guidance, and no evidence-based, condition-specific recommendations currently exist.4,5

Methods

This single-site, cross-sectional study evaluated sleep practices, caregiver education, and barriers to adherence among parents of children (< 3 years) with CL/P treated at CHKD’s Craniofacial Program. Eligible caregivers (n=117) were identified via query of the electronic medical record by CHKD Data Governance and invited to complete an anonymous REDCap survey assessing demographics, sleep environment, counseling, and understanding of safe-sleep recommendations.

Results & Conclusions

Of the 11 caregivers who completed the survey, 91% reported crib sleep, though several also used beds, couches, …


Optimizing Continuous Renal Replacement Therapy (Crrt) In The Icu: A Qsen-Based Framework For Nursing Decision-Making Support, Leslie Okhirkhian Mar 2026

Optimizing Continuous Renal Replacement Therapy (Crrt) In The Icu: A Qsen-Based Framework For Nursing Decision-Making Support, Leslie Okhirkhian

Knowledge and Creativity Expo

Nurses in critical care environments must exercise precise clinical judgement to recognize patient destabilization cues while managing the complex biomedical technologies that support failing physiological systems. Continuous Renal Replacement Therapy (CRRT) is a modality for hemodynamically unstable patients requiring fluid overload management and waste removal; however, it is a complex technology that demands nurses navigate a “tightrope” between renal perfusion and hemodynamic stability. Despite its prevalence, there is no concise decision-making support for nursing care in the current literature based on the Quality and Safety Education for Nurses (QSEN) strategies. This presentation addresses this gap by proposing a QSEN-based, standardized …


Evaluating Sensory Sensitivities Among Children With Autism Spectrum Disorder In An Adaptive Gymnastics Program, Aicha Kaouss, Bradley Eppinger, Austin Ebbrecht, Kailash Ram, Kaitlin P. Hardy Md Mar 2026

Evaluating Sensory Sensitivities Among Children With Autism Spectrum Disorder In An Adaptive Gymnastics Program, Aicha Kaouss, Bradley Eppinger, Austin Ebbrecht, Kailash Ram, Kaitlin P. Hardy Md

Knowledge and Creativity Expo

Introduction: Children with autism spectrum disorder (ASD) participate in physical activity at lower rates than their neurotypical peers1. Sensory sensitivities, reported in approximately 75–95% of children with ASD, may contribute to this disparity2. Gymnastics environments involve bright lighting and loud noise, which can precipitate sensory overload. The impact of specific sensory features on participation in adaptive gymnastics remains underexplored.

Methods: A cross-sectional study recruited caregivers of children aged 3–12 years with an ASD diagnosis enrolled in the EVMS Adaptive Gymnastics Program. Caregivers completed the Sensory Experiences Questionnaire–Third Edition (SEQ-3)3 and supplemental survey items on Redcap which assessed environmental triggers and …


Parental Safe Sleep Knowledge And Infant Safe Sleep Practices In Tidewater, Virginia, Karen Hancock, Kathie Zimbrow, Carolyn Rutledge Mar 2026

Parental Safe Sleep Knowledge And Infant Safe Sleep Practices In Tidewater, Virginia, Karen Hancock, Kathie Zimbrow, Carolyn Rutledge

Knowledge and Creativity Expo

Tidewater, VA has the highest SIDS rate in the state. The purpose of this submission is to contribute to the limited knowledge available on parental knowledge and infant safe sleep practices in Tidewater, VA. Through this study we have attempted to identify impediments to infant safe sleep practices and hope to use this information to address gaps in education on infant safe sleep practices.

This abstract will be presented in poster presentation form and is appropriate for the following categories: Maternal, Child, and Neonatal Nursing as well as Public Health and Community Nursing.

Contributions to this work were made by …


Evidence-Based Practice Medication Reconciliation Protocol: Process To Increase Adherence To Medication Reconciliation Process, Oksana Bregman Mar 2026

Evidence-Based Practice Medication Reconciliation Protocol: Process To Increase Adherence To Medication Reconciliation Process, Oksana Bregman

Student Scholarly Projects

Practice Problem: The practice problem for the primary care facility is the inconsistent completion of medication reconciliation (MR) by primary care providers (PCPs), despite attempts by some providers to compare the clinic medication list with the external records and update the electronic health records (EHR). The absence of a standardized evidence-based practice (EBP) MR protocol has resulted in variable practices and increased risk for medication discrepancies during patient encounters.

PICOT: The PICOT question that guided this project was: In primary care providers (P), how does the Evidence-based practice process redesign and workflow optimization protocol (I) compared to current practice (C) …


Parents Engaging In Early Literacy (Peel): Outcomes From A Shared Reading Program Implemented Via Text Messaging, Victoria Henbest, Brenda L. Beverly, Gina M. Mejia Mar 2026

Parents Engaging In Early Literacy (Peel): Outcomes From A Shared Reading Program Implemented Via Text Messaging, Victoria Henbest, Brenda L. Beverly, Gina M. Mejia

Victoria S. Henbest Publications

Purpose: Investigators delivered an asynchronous parent education for improving early literacy skills of typically developing preschoolers. The home-based shared-book reading program, PEEL, consisted of strategies modeled via videos and sent as text messages.

Method: Twenty parent-child dyads were randomly assigned to one of two 8-week programs targeting evidence-based early literacy strategies. One parent group was taught strategies to support print-related knowledge for learning to read, and the other learned skills to promote vocabulary and story knowledge underlying comprehension.

Results: The asynchronous parent education resulted in more frequent parental use of taught strategies compared to non-taught strategies during …


Randomized Controlled Trial Outcomes For Homestyles-2, An Online Obesity Prevention Program For Families With Children In Middle Childhood, Carol Byrd-Bredbenner, Angelica A. Pozzoli, Kaitlyn M. Eck, John Worobey, Karla Pagan Shelnutt, Melissa D. Olfert, Virginia Quick Mar 2026

Randomized Controlled Trial Outcomes For Homestyles-2, An Online Obesity Prevention Program For Families With Children In Middle Childhood, Carol Byrd-Bredbenner, Angelica A. Pozzoli, Kaitlyn M. Eck, John Worobey, Karla Pagan Shelnutt, Melissa D. Olfert, Virginia Quick

College of Health Professions Faculty Papers

Background: Parents are children’s primary role models, are food and physical activity gatekeepers, and create the home structure/lifestyle environment. Thus, parents strongly influence children’s weight-related behaviors and have the opportunity to cultivate a “culture of health” within the home. Methods: The aim of the HomeStyles-2 (also called HomeStyles-Child) RCT was to determine whether this online, novel, age-appropriate, family intervention enabled and motivated the 131 systematically randomly assigned by computer parents of children in middle childhood (ages 6 to 11) in the experimental condition to shape home environments and healthy weight-related lifestyle practices to be more supportive of optimal health and …


The Psychology Of Offensive And Defensive Intergroup Violence: Preregistered Insights From 58 Countries, Jonas R. Kunst, Tomasz Besta, Michał Jaśkiewicz, Et Al, Lauren E. Duncan Mar 2026

The Psychology Of Offensive And Defensive Intergroup Violence: Preregistered Insights From 58 Countries, Jonas R. Kunst, Tomasz Besta, Michał Jaśkiewicz, Et Al, Lauren E. Duncan

Psychology: Faculty Publications

Historically, intergroup violence has been motivated by both offensive and defensive goals, often blending narratives of protection with ambitions of domination. In a preregistered study spanning 58 countries, we show that defensive and offensive extremist intentions are positively correlated yet psychologically distinct, relating differently to individual and societal factors. Defensive extremist intentions were far more common and primarily linked to narcissism and Machiavellianism, whereas offensive extremist intentions were primarily associated with social dominance orientation and religious fundamentalism, were lower in more democratic and developed societies, and higher in those experiencing violence and conflict. This global evidence suggests that violent extremist …


How Does Striving Against Adversity Impact Emotional Well-Being And Cardiovascular Risk In Children?, Brooks B. Gump, Stefanie Pilkay, Xiafei Wang, Sara Vasilenko, Nader H. Attallah-Yunes, Sarah Woolf-King, Stephen Maisto, Edith Chen, Craig K. Ewart Mar 2026

How Does Striving Against Adversity Impact Emotional Well-Being And Cardiovascular Risk In Children?, Brooks B. Gump, Stefanie Pilkay, Xiafei Wang, Sara Vasilenko, Nader H. Attallah-Yunes, Sarah Woolf-King, Stephen Maisto, Edith Chen, Craig K. Ewart

Population Health Research Brief Series

Working hard and persisting through challenges (i.e., striving) are often encouraged for children who face adversity.  But for children facing severe adversity, striving can come with hidden costs. This brief summarizes findings from a study using data from the Environmental Exposures and Child Health Outcomes (EECHO) cohort (N=283, 2013-2017) of children ages 9-11 in Syracuse, NY. The authors find that children facing adversity who strived harder reported lower depression and hostility. However, high-striving high-adversity children also experienced significantly higher blood pressure and enlarged heart chambers than their lower striving peers, both risk factors for future heart disease.


Molecular Characterization Of Humanized Apoe Mouse Models Reveals Source And Genotype Dependent Differences, Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani, Suren Jeevaratnam, Xue Zhang, Meghan Mcreynolds, Yuzhou Chang, Fangfang Qi, William Tauer, Cassandra Rosenberg, Melissa Wren, Tadafumi C Ikezu, Yuka A Martens, Minghui Wang, Bin Zhang, Gregory W Carter, Michael Sasner, David M Holtzman, Junmin Peng, Long-Jun Wu, Takahisa Kanekiyo, Chia-Chen Liu, Guojun Bu Mar 2026

Molecular Characterization Of Humanized Apoe Mouse Models Reveals Source And Genotype Dependent Differences, Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani, Suren Jeevaratnam, Xue Zhang, Meghan Mcreynolds, Yuzhou Chang, Fangfang Qi, William Tauer, Cassandra Rosenberg, Melissa Wren, Tadafumi C Ikezu, Yuka A Martens, Minghui Wang, Bin Zhang, Gregory W Carter, Michael Sasner, David M Holtzman, Junmin Peng, Long-Jun Wu, Takahisa Kanekiyo, Chia-Chen Liu, Guojun Bu

The Brown Foundation: Institute of Molecular Medicine

Background

Humanized APOE targeted-replacement (TR) mice are essential tools for studying apoE isoform effects in Alzheimer’s disease (AD) and other apoE-related disorders. Despite their widespread use, existing APOE mouse models, generated with different gene targeting strategies, have not been directly compared in terms of apoE isoform expression, lipid profiles, and transcriptomic signatures. Such differences could impact how we interpret APOE genotype-related outcomes, as well as related underlying molecular mechanisms.

Methods

We conducted a comprehensive molecular comparison of humanized APOE mouse models from three sources: Taconic Biosciences (TAC), the Cure Alzheimer’s Fund (CAF), and The Jackson Laboratory (JAX). We assessed apoE …


Contrast-Associated Acute Kidney Injury After Thrombectomy For Ischemic Stroke: Prognostic Impact And Can-Rest Predictive Score, Ghil Schwarz, Angelo Cascio Rizzo, Gareth Ambler, Pawel Wrona, Agnieszka Slowik, Szymonn Kotas, Mohamed F. Doheim, Alhamza R. Al-Bayati, Raul G. Nogueira, Ameer E. Hassan, Samantha Miller Mar 2026

Contrast-Associated Acute Kidney Injury After Thrombectomy For Ischemic Stroke: Prognostic Impact And Can-Rest Predictive Score, Ghil Schwarz, Angelo Cascio Rizzo, Gareth Ambler, Pawel Wrona, Agnieszka Slowik, Szymonn Kotas, Mohamed F. Doheim, Alhamza R. Al-Bayati, Raul G. Nogueira, Ameer E. Hassan, Samantha Miller

School of Medicine Publications

Background and objectives: Contrast-associated acute kidney injury (CA-AKI) is a potentially preventable complication after exposure to iodinated contrast media. In patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke (AIS), the incidence and clinical impact are poorly characterized, and no validated prediction tool is currently available. The aim of this study was to assess the incidence and prognostic significance of CA-AKI in EVT-treated patients with AIS and to develop and validate a predictive score.

Methods: A retrospective, multicenter cohort study was conducted involving EVT-treated patients across 73 centers in 16 countries (January-December 2023). Inclusion criteria were age ≥18 years, absence …


Thalamic Organization Differentially Contributes To Clinical Conditions In Epilepsy, Qirui Zhang, Sam S. Javidi, Ankeeta Ankeeta, Michael R. Sperling, Zhiqiang Zhang, Joseph I. Tracy Mar 2026

Thalamic Organization Differentially Contributes To Clinical Conditions In Epilepsy, Qirui Zhang, Sam S. Javidi, Ankeeta Ankeeta, Michael R. Sperling, Zhiqiang Zhang, Joseph I. Tracy

Farber Institute for Neuroscience Faculty Papers

BACKGROUND: The thalamus plays an important role in key clinical conditions of focal temporal lobe epilepsy (TLE), but no investigation has examined whether the same thalamic local and connectome properties shape a patient's status across these different conditions.

METHODS: This retrospective longitudinal MRI study used resting-state fMRI and structural imaging to identify whole-brain focal/regional and connectome-level features associated with six binary clinical conditions of TLE (pre/post-surgery, seizure and neurocognitive outcomes, pathology, seizure subtype, and SOZ lateralization) in 91 patients across two centers (age range: 15-65 years) and 85 matched healthy participants (age range: 18-60 years).

RESULTS: Across conditions, relative to …


Racial And Ethnic Differences In The Clinical Presentation Of Celiac Disease In The United States: A Multi-Institutional Retrospective Analysis, Joy Zhao, John C. Lin, Jason C. Lin, Stephanie M. Moleski Mar 2026

Racial And Ethnic Differences In The Clinical Presentation Of Celiac Disease In The United States: A Multi-Institutional Retrospective Analysis, Joy Zhao, John C. Lin, Jason C. Lin, Stephanie M. Moleski

Division of Gastroenterology and Hepatology Faculty Papers

No abstract provided.


Molecular Characterization Of Humanized Apoe Mouse Models Reveals Source And Genotype Dependent Differences, Na Wang, David M Holtzman, Et Al. Mar 2026

Molecular Characterization Of Humanized Apoe Mouse Models Reveals Source And Genotype Dependent Differences, Na Wang, David M Holtzman, Et Al.

2020-Current year OA Pubs

BACKGROUND: Humanized APOE targeted-replacement (TR) mice are essential tools for studying apoE isoform effects in Alzheimer’s disease (AD) and other apoE-related disorders. Despite their widespread use, existing APOE mouse models, generated with different gene targeting strategies, have not been directly compared in terms of apoE isoform expression, lipid profiles, and transcriptomic signatures. Such differences could impact how we interpret APOE genotype-related outcomes, as well as related underlying molecular mechanisms. METHODS: We conducted a comprehensive molecular comparison of humanized APOE mouse models from three sources: Taconic Biosciences (TAC), the Cure Alzheimer’s Fund (CAF), and The Jackson Laboratory (JAX). We assessed apoE …


Impact Of Prior Bendamustine Exposure On Bispecific Antibody Outcomes In Relapsed/Refractory Follicular Lymphoma, Gloria Iacoboni, David A Russler-Germain, Jing Luan, Et Al. Mar 2026

Impact Of Prior Bendamustine Exposure On Bispecific Antibody Outcomes In Relapsed/Refractory Follicular Lymphoma, Gloria Iacoboni, David A Russler-Germain, Jing Luan, Et Al.

2020-Current year OA Pubs

No abstract provided.