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Articles 7741 - 7770 of 324827
Full-Text Articles in Medicine and Health Sciences
Improving Collaboration Between Rns And Crnas For Informed Consents, Bella Warren, Aliyah Frutiger
Improving Collaboration Between Rns And Crnas For Informed Consents, Bella Warren, Aliyah Frutiger
Scholars Week
This presentation focuses on improving collaboration and communication between Registered Nurses (RNs) and Certified Registered Nurse Anesthetists (CRNAs) to help with the informed consent process for epidurals during labor. It emphasizes that obtaining informed consent during active labor can impair the patient’s cognitive function from pain and stress. The research shows that earlier education, prior to severe pain, improves the quality of comprehension the patient has during the process. Therefore they will be able to fully understand the risks, benefits and alternatives to epidural anesthesia.
Shared Decision-Making For Patient Compliance, Lydia Vernon, Breanna Day
Shared Decision-Making For Patient Compliance, Lydia Vernon, Breanna Day
Scholars Week
This evidence-based project focuses on shared decision-making between the healthcare team and the patient. As well as how this implementation affects patient compliance. An issue of patient noncompliance was brought to attention, and this project will address how shared decision-making interventions can decrease patients’ feelings of overwhelmingness and underpreparedness, ultimately leading to better compliance after discharge. By focusing on these interventions, patient compliance increases, and as a result, patient outcomes benefit, and readmission rates decline.
The Standardization Of Protocols For Lines And Drips In Complex Cases, Allee A. Rudolph
The Standardization Of Protocols For Lines And Drips In Complex Cases, Allee A. Rudolph
Scholars Week
Medication errors occur far too often, yet many can be prevented through simple measures such as intravenous line labeling. Clear, highly visible labels enable quick identification reducing the response time in critical situations. The incorporation of color-coding and icons can only enhance the ability to distinguish between the lines with confidence.
Reducing Falls Through Innovative Assessment Scales, Emily Oliver, Alisa Helt
Reducing Falls Through Innovative Assessment Scales, Emily Oliver, Alisa Helt
Scholars Week
Fall occurrences remain an important issue in hospital settings that contribute to longer hospital stays, higher healthcare costs, and increased health risks for patients. This evidence based practice project evaluates current research that addresses how to reduce the amount of falls that occur in hospitals, specifically through innovative fall risk assessments. Key findings from the studies include the use of the Activity Measure for Post-Acute Care (AM-PAC) and the Modified Dionne’s Egress Test as a means to evaluate patients mobility function, and therefore gain a better understanding of how at risk a patient is for falls.
Implementation Of A Dual-Registered Nurse Skin Assessment Protocol To Reduce Hospital Acquired Pressure Injuries, Kaylie V. Newbold, Nishita Trivedi, Mckenzie Clendenen, Jariah Mcdaniel
Implementation Of A Dual-Registered Nurse Skin Assessment Protocol To Reduce Hospital Acquired Pressure Injuries, Kaylie V. Newbold, Nishita Trivedi, Mckenzie Clendenen, Jariah Mcdaniel
Scholars Week
Hospital-acquired pressure injuries(HAPIs) remain a significant patient safety concern due to gaps in early detection, lack of structured skin assessments, and thorough documentation. This evidence based practice project proposes a dual-Registered Nurse skin assessment protocol, requiring two Registered Nurses to perform a full risk assessment and co-sign documentation, within two hours of hospital admission, and every 12 hours thereafter. Implementing these practices will improve accuracy, reduce missed injuries, further improve the use of other skin assessment tools such as the Braden Scale. This set of interventions promotes early detection, prevention, accountability, and improved patient outcomes, guided by the Health Promotion …
Reducing Nurse Burnout, Kaylee R. Mofield
Reducing Nurse Burnout, Kaylee R. Mofield
Scholars Week
I presented an evidence-based project to a healthcare facility with interventions and a suggested policy change to help reduce nurse burnout. One suggested policy change I made was changing the staffing policy. Within this new policy I suggest that if the patient census was 25 patients it calls for 5 nurses, 17-20 patient calls for 4 nurses, 16 or less patients calls for 3 nurses; along with no calling off staff due to census but rather utilizing this staff as a float or resource nurse. Another suggestion I made was nursing leadership holding monthly “check-in” meetings separate from the monthly …
Fast Track In The Emergency Department, Raegan Luechtefeld, Ella Kjellberg
Fast Track In The Emergency Department, Raegan Luechtefeld, Ella Kjellberg
Scholars Week
Emergency departments nationwide all consistently work to improve efficiency and patient care, reduce wait times to be seen and length of stay, decrease overcrowding, and increase both staff and patient satisfaction. One way to utilize evidence-based practice and provide better patient outcomes is to implement “fast tracks” into emergency departments. This is used as a triage tool in order to separate critical patients from ones with minor illnesses and injuries. Fast tracks help to accomplish all of the stated goals by helping the providers and nurses to give more specialized and efficient care. The purpose of this evidence-based practice project …
Decreasing Wound Healing Times By Decreasing Stress Levels, Bayleigh S. Kraus, Colson Burnett, Kelsey Spann
Decreasing Wound Healing Times By Decreasing Stress Levels, Bayleigh S. Kraus, Colson Burnett, Kelsey Spann
Scholars Week
The relationship between stress levels and delayed wound healing needs to be further investigated, particularly in hospitalized and chronically ill patients. Research shows that psychological stress can impair immune function, reduce tissue regeneration, and prolong inflammation, all of which slow the healing process. It is important to explore how both acute and chronic stress affect different types of wounds, such as surgical incisions, pressure injuries, and diabetic ulcers. Additionally, identifying which stress-reduction interventions are most effective in improving healing outcomes is essential. Understanding these factors can help nurses implement targeted, evidence-based interventions to promote faster recovery.
Implementing Labor Plans To Increase Labor Satisfaction, Allyson G. Johnson, Emma G. Hancock, Kinley Edwards
Implementing Labor Plans To Increase Labor Satisfaction, Allyson G. Johnson, Emma G. Hancock, Kinley Edwards
Scholars Week
This scholarly presentation examines the implementation of a standardized birth plan tool within a healthcare facility to improve maternal birth satisfaction. The project focuses on enhancing patient-provider communication, supporting shared decision-making, and ensuring that patient preferences are clearly documented and respected throughout labor and delivery. Findings suggest that integrating a structured birth plan tool may increase maternal satisfaction and promote more patient-centered obstetric care.
Reducing 30-Day Readmissions: Simplifying Discharge, Olivia Hibbs
Reducing 30-Day Readmissions: Simplifying Discharge, Olivia Hibbs
Scholars Week
Hospital readmissions within 30 days remain a major challenge for healthcare systems and are often linked to ineffective discharge communication and low patient health literacy. Improving discharge planning through simplified instructions, early education, and the teach-back method can help ensure patients understand their medications, follow-up care, and warning signs after leaving the hospital. Strengthening communication and care coordination during the transition from hospital to home may improve patient outcomes and reduce preventable readmissions.
Meds-To-Beds Improving Medication Adherence, Hannah Draper, Regan Ashby, Ryan Rieke
Meds-To-Beds Improving Medication Adherence, Hannah Draper, Regan Ashby, Ryan Rieke
Scholars Week
The Meds-to-Beds program improves medication adherence by delivering prescribed medications directly to patients before hospital discharge, ensuring timely access and reducing barriers such as transportation or pharmacy delays. By incorporating bedside education from pharmacists, patients gain a clearer understanding of their medications, which enhances confidence and proper use. This coordinated approach has been shown to decrease readmission rates and improve overall patient outcomes.
Implementing A Health Literacy Assessment To Reduce Readmissions, Saiylor M. Beecham, Jewel Render, Bethany Pruitt
Implementing A Health Literacy Assessment To Reduce Readmissions, Saiylor M. Beecham, Jewel Render, Bethany Pruitt
Scholars Week
This presentation examines the impact of limited health literacy on patient outcomes, highlighting its role in medication errors and hospital readmissions. Grounded in Dorothea Orem’s Self-Care Deficit Theory, it emphasizes the importance of implementing standardized, non-stigmatizing health literacy assessments to improve nurse-patient communication and patient understanding. Evidence-based strategies such as teach-back methods and plain language education are recommended to enhance patient safety and reduce preventable readmissions.
Femoral Structure And Biomechanical Characteristics In Sanfilippo Syndrome Type-B Mice, Frederick J. Ashby, Evelyn J. Castillo, Yan Ludwig, Natalia K. Andraka, Cong Chen, Julia C. Jamieson, Nadia Kabbej, John D. Summerville, Jose I. Aquirre, Coy D. Heldermon, University Of Florida
Femoral Structure And Biomechanical Characteristics In Sanfilippo Syndrome Type-B Mice, Frederick J. Ashby, Evelyn J. Castillo, Yan Ludwig, Natalia K. Andraka, Cong Chen, Julia C. Jamieson, Nadia Kabbej, John D. Summerville, Jose I. Aquirre, Coy D. Heldermon, University Of Florida
Knowledge and Creativity Expo
Sanfilippo syndrome Type-B, also known as mucopolysaccharidosis IIIB (MPS IIIB), accounts for approximately one-third of all Sanfilippo syndrome patients and is characterized by a similar natural history as Type-A. Patients suffer from developmental regression, bone malformation, organomegaly, GI distress, and profound neurological deficits. Despite human trials of enzyme replacement therapy (ERT) (SBC-103, AX250) in MPS IIIB, there is currently no FDA approved treatment and a few palliative options. The major concerns of ERT and gene therapy for the treatment of bone malformation are the inadequate biodistribution of the missing enzyme, N-acetyl-α-glucosaminidase (NAGLU), and that the skeleton is a poorly hit …
Incidental Left Ventricular Fibroma Detected During Pre-Participation Screening In A Young Athlete, Alya J. Al Hashmi, Meetha S. Al Ameri, Asna Ayoob, Hafsa Maryam, Fiza Halima
Incidental Left Ventricular Fibroma Detected During Pre-Participation Screening In A Young Athlete, Alya J. Al Hashmi, Meetha S. Al Ameri, Asna Ayoob, Hafsa Maryam, Fiza Halima
Journal of the Saudi Heart Association
Primary cardiac fibromas are rare benign tumors that may carry arrhythmic risk. We report a case of cardiac fibroma that was incidentally detected in an 18-year-old athlete with echocardiography and MRI during routine pre-championship screening. Following multidisciplinary heart team discussion and shared decision-making, surgical excision was performed due to potential arrhythmic risk in the setting of high-intensity athletic activity.
Influence Of Serve Type And Speed On Passing Success In Elite Czech Men's Volleyball, Miroslav Krajcigr, Petr Bahenský, David Marko, Sára Šestáková, Ladislav Čepička
Influence Of Serve Type And Speed On Passing Success In Elite Czech Men's Volleyball, Miroslav Krajcigr, Petr Bahenský, David Marko, Sára Šestáková, Ladislav Čepička
Baltic Journal of Health and Physical Activity
Background: Serve effectiveness plays a critical role in volleyball, influencing the opponent’s reception and subsequent attack. While smash serves are powerful, float serves may disrupt the opponent through unpredictable flight patterns. This study examined how serve type and speed affect reception quality in elite men’s volleyball. Methods: A total of 543 serves (254 float, 289 smash) from one Czech Extraliga team across seven home matches were analyzed using video recordings and radar measurements. Serve speeds were grouped into predefined categories. Effectiveness was defined as the sum of effective receptions and aces; error serves were excluded. Reception outcomes were classified as …
Examining The Relationship Between A Positive Obstructive Sleep Apnea Diagnosis And Referring Symptoms Of The Pregnant Patient, Christina Emerson, Beth Tremblay
Examining The Relationship Between A Positive Obstructive Sleep Apnea Diagnosis And Referring Symptoms Of The Pregnant Patient, Christina Emerson, Beth Tremblay
Knowledge and Creativity Expo
PROBLEM: Many healthcare providers do not routinely screen pregnant individuals for obstructive sleep apnea (OSA), contributing to its underdiagnosis and potentially leading to various pregnancy-related health issues. Currently used OSA screening tools, such as the Berlin Questionnaire, STOP-BANG Questionnaire, and Epworth Sleepiness Scale, often demonstrate poor predictive value in pregnant women due to the dynamic physiological changes of pregnancy and the differing presentation of OSA in this population.
PURPOSE: To examine the relationships between a positive OSA diagnosis, patient characteristics, and the symptoms among pregnant patients referred for sleep studies.
EBP QUESTIONS: 1) Is there a relationship between certain referring …
Predicting Trauma Admission In Anticoagulated Geriatric Patients Presenting With A Ground Level Fall, Y-Nhi H. Bui Ms, Trevor Glad Bmus, Dylan Jack Bs, Michael Martyak
Predicting Trauma Admission In Anticoagulated Geriatric Patients Presenting With A Ground Level Fall, Y-Nhi H. Bui Ms, Trevor Glad Bmus, Dylan Jack Bs, Michael Martyak
Knowledge and Creativity Expo
Our study undertook a rigorous investigation into an expanding trauma patient population, tackling some of the significant challenges with this patient population in trauma triage. Our research has not only addressed key questions, but has also paved the way for future inquiries by offering innovative perspectives. This presentation is particularly important given the current advancements and interests in geriatric trauma. We hope that our findings will influence ongoing projects and spark collaborations among diverse research communities.
Heterotopic Pancreas Masquerading As Barrett’S Esophagus, Suravi Khanal, Shama Bhandari, Anish Paudel
Heterotopic Pancreas Masquerading As Barrett’S Esophagus, Suravi Khanal, Shama Bhandari, Anish Paudel
Tower Health Research Day
No abstract provided.
Interview With Orca Award Winner David Hage, Unl Chemistry; Drug-Protein Interactions, Mark Griep, David Hage
Interview With Orca Award Winner David Hage, Unl Chemistry; Drug-Protein Interactions, Mark Griep, David Hage
UNL ORCA Interview Series
Prof. David Hage was awarded the ORCA in 2018. He was born in La Crosse, Wisconsin, and earned a bachelor’s in chemistry at the University of Wisconsin in La Crosse. Next, he earned a doctorate from Iowa State University and did postdoctoral work at the Mayo Clinic in Rochester, Minnesota. In 1989, he joined UNL as an assistant professor of chemistry and quickly rose through the ranks. He has won many awards and, for the past 13 years, has been the James Hewet University Professor of Chemistry. Allow me to share some remarkable facts about Dave before we get into …
Dyadic Internalized Stigma, Resilience, And Psychological Distress Among People With Hiv And Their Family Members: An Actor-Partner Interdependence Mediation Model Analysis, Fanghui Shi, Xueying Yang, Shan Qiao Ph.D., Cheuk Chi Tam Ph.D., M.S., M.A., Shuaifeng Liu, Yuejiao Zhou, Xiaoming Li Ph.D.
Dyadic Internalized Stigma, Resilience, And Psychological Distress Among People With Hiv And Their Family Members: An Actor-Partner Interdependence Mediation Model Analysis, Fanghui Shi, Xueying Yang, Shan Qiao Ph.D., Cheuk Chi Tam Ph.D., M.S., M.A., Shuaifeng Liu, Yuejiao Zhou, Xiaoming Li Ph.D.
Faculty Publications
Despite robust evidence showing the mediation role of psychological resilience in the impacts of HIV-related stigma on psychological distress, most studies were conducted from an intrapersonal perspective. Limited studies have examined the dyadic effects of HIV-related stigma and resilience on psychological distress for people with HIV (PWH) and their family members. This study aimed to explore the actor-partner effect and the mediation role of resilience in the relationship between internalized stigma and psychological distress among PWH and family members dyads. Between October 2023 and December 2023, a total of 800 PWH-family member dyads were recruited from two urban cities and …
A Livelihood Intervention Improved Nutritional, Mental Health And Sexual Health Outcomes Among Hiv-Affected Adolescents In Western Kenya: Results From The Shamba Maisha Randomised Controlled Trial, Sheri D. Weiser, Lila Aziz Sheira, Pauline Wekesa, Jennifer Monroe Zakaras, Edward A. Frongillo Jr. Ph.D., Elly Weke, Jason M. Nagata, Amy A. Conroy, Marguerita Lightfoot, Torsten B. Neilands, Lisa M. Butler, Elizabeth A. Bukusi, Craig R. Cohen, Maricianah Atieno Onono
A Livelihood Intervention Improved Nutritional, Mental Health And Sexual Health Outcomes Among Hiv-Affected Adolescents In Western Kenya: Results From The Shamba Maisha Randomised Controlled Trial, Sheri D. Weiser, Lila Aziz Sheira, Pauline Wekesa, Jennifer Monroe Zakaras, Edward A. Frongillo Jr. Ph.D., Elly Weke, Jason M. Nagata, Amy A. Conroy, Marguerita Lightfoot, Torsten B. Neilands, Lisa M. Butler, Elizabeth A. Bukusi, Craig R. Cohen, Maricianah Atieno Onono
Faculty Publications
Introduction Interventions that address household-level factors, including food insecurity (FI) and poverty, may reduce HIV risk and improve sexual and reproductive health (SRH) among adolescent girls and young women (AGYW).
Methods This cluster randomised controlled trial in Kenya assessed AGYW living in households of adults enrolled in Shamba Maisha (SM). SM was a multisectoral agricultural livelihood intervention designed to improve HIV health. At the trial end, we used linear and logistic regressions to compare differences between the intervention and control arms in FI, and mental health among AGYW-caregiver pairs and SRH outcomes among the AGYW, accounting for clusters with robust …
Nerandomilast In Progressive Pulmonary Fibrosis: Data From The Whole Follow-Up Period Of The Fibroneer-Ild Trial, Marlies S Wijsenbeek, Shervin Assassi, Arata Azuma, Vincent Cottin, Anna-Maria Hoffmann-Vold, Toby M Maher, Fernando J Martinez, Justin M Oldham, Luca Richeldi, Claudia Valenzuela, Hui Gu, Ivana Ritter, Susanne Stowasser, Michael Kreuter
Nerandomilast In Progressive Pulmonary Fibrosis: Data From The Whole Follow-Up Period Of The Fibroneer-Ild Trial, Marlies S Wijsenbeek, Shervin Assassi, Arata Azuma, Vincent Cottin, Anna-Maria Hoffmann-Vold, Toby M Maher, Fernando J Martinez, Justin M Oldham, Luca Richeldi, Claudia Valenzuela, Hui Gu, Ivana Ritter, Susanne Stowasser, Michael Kreuter
Faculty, Staff and Student Publications
Background: In the FIBRONEER-ILD trial in patients with progressive pulmonary fibrosis (PPF), nerandomilast 9 mg bid and 18 mg bid reduced the decline in forced vital capacity at week 52 compared with placebo (the primary endpoint). We assessed the effects of nerandomilast up to the final database lock.
Methods: Time to first acute exacerbation of ILD, hospitalisation for respiratory cause, or death (key secondary endpoint) and other time-to-event endpoints were assessed.
Results: 1176 patients, of whom 512 were taking background nintedanib, received nerandomilast or placebo. At final database lock, mean (sd) exposure to trial medication was 15.1 (5.7) months and …
The Development Of A Framework To Classify Medication Deprescribing Among Patients With Type 2 Diabetes In Primary Care Practices, Puja B Gandhi, Yoav Jacob, Joeita F Macfield, Gia Merlo, Stefanie M Meyer, Shivani S Patel, Caroline Rhéaume, Kara L Staffier, Madeline Watson, Micaela C Karlsen
The Development Of A Framework To Classify Medication Deprescribing Among Patients With Type 2 Diabetes In Primary Care Practices, Puja B Gandhi, Yoav Jacob, Joeita F Macfield, Gia Merlo, Stefanie M Meyer, Shivani S Patel, Caroline Rhéaume, Kara L Staffier, Madeline Watson, Micaela C Karlsen
Faculty, Staff and Student Publications
No abstract provided.
Strategic Planning Time Horizons And Hospital Performance Outcomes, David Meyer
Strategic Planning Time Horizons And Hospital Performance Outcomes, David Meyer
MUSC Theses and Dissertations
Background: Despite widespread adoption of strategic planning in healthcare, empirical evidence linking strategic planning time horizons to hospital financial and quality performance outcomes remains limited. Healthcare executives invest substantial resources in strategic planning processes, yet lack evidence-based guidance on whether longer or shorter planning horizons yield enhanced financial and quality-related results.
Methods: This study employed an exploratory sequential mixed-methods design combining executive survey data with archival performance data. A REDCap survey was administered to 22 hospital CEOs, CFOs, and other C-suite executives between January and February 2026. Survey responses were matched to publicly available financial and quality performance data from …
Measurable Gains In Understanding Interprofessional Competencies: Insights From Medical Student Clerkship Observation Of A Nicu Graduate Follow-Up Clinic, Grace Berentson, Liliana Bronner, Neil Kalsi, Paige Hardy, Brianna Brei, Kerry Miller
Measurable Gains In Understanding Interprofessional Competencies: Insights From Medical Student Clerkship Observation Of A Nicu Graduate Follow-Up Clinic, Grace Berentson, Liliana Bronner, Neil Kalsi, Paige Hardy, Brianna Brei, Kerry Miller
Posters and Presentations: Family Medicine
No abstract provided.
Evaluating U.S. Health Policy Levers Using Difference-In-Differences: Hospital Acquisitions, Global Budgets, And Income Policies, Kola Adegoke
NYMC Student Theses and Dissertations
Abstract
Background: U.S. health policy relies on multiple levers to influence system performance, financial stability, and population health. This dissertation uses a three-paper portfolio to evaluate organizational change (hospital acquisitions), payment reform (Maryland all-payer global budgets), and income-related state policies, applying difference-in-differences (DiD) designs with prespecified diagnostics to support causal interpretation.
Methods: Study 1 examined hospital change-of-ownership (CHOW) acquisitions using a national hospital-year panel from RAND HCRIS (2014–2023), linked to CHOW timing data from 2016–2023. Effects on revenue outcomes were estimated using a staggered difference-in-differences design implemented with the Callaway and Sant’Anna estimator, using doubly robust inverse probability weighting, hospital-level …
Assessing Type 2 Diabetes Mellitus, Christine A. Mccaulay
Assessing Type 2 Diabetes Mellitus, Christine A. Mccaulay
Walden Dissertations and Doctoral Studies
This Doctor of Nursing Practice capstone project presents the development and evaluation of a clinical practice guideline (CPG) for the assessment and management of Type 2 Diabetes Mellitus in adults. The project addresses the ongoing challenge of diabetes-related complications and hospitalizations, highlighting the critical role of personalized patient education and the integration of smartphone technology for home monitoring. Central to this initiative was the question of whether an expert panel would endorse an evidence-based guideline for diabetes monitoring using innovative technology, as evaluated by the AGREE II tool. A robust review of the literature supported the guideline’s development, with high-quality …
Reducing Social Isolation In Elderly Hospice Patients Through Structured Social Interventions, Ashley Babayan
Reducing Social Isolation In Elderly Hospice Patients Through Structured Social Interventions, Ashley Babayan
Walden Dissertations and Doctoral Studies
This doctoral project was conducted as a quality improvement organizational change initiative aimed at reducing social isolation among elderly hospice patients through structured social interventions. Social isolation is a significant psychosocial concern in hospice populations and is associated with increased emotional distress, depression, and decreased quality of life. Despite hospice care’s holistic philosophy, structured and standardized social engagement interventions are inconsistently implemented across settings, creating a gap in practice. The practice-focused question guiding this project was: In elderly hospice patients experiencing social isolation, how do structured social interventions (regular visits, group activities, and emotional support systems), compared to standard hospice …
Socioeconomic Disparities In Readmission Outcomes And Cardiac Procedures Among Atrial Fibrillation Hospitalizations, Muhammad U. Almani, Muhammad Yousuf, Noor Fatima, Muhammad Q. Ullah, Muhammed Arshad
Socioeconomic Disparities In Readmission Outcomes And Cardiac Procedures Among Atrial Fibrillation Hospitalizations, Muhammad U. Almani, Muhammad Yousuf, Noor Fatima, Muhammad Q. Ullah, Muhammed Arshad
Einstein Health Papers
Introduction: Atrial fibrillation (AF) remains one of the leading dysrhythmias incurring hospitalization. We set out to determine the impact of socioeconomic status (SES) on in-hospital cardiac procedures and the readmission outcomes in patients with AF. Methods: The National Readmission Database (NRD) was searched for adults with a primary diagnosis of AF between 2010 and 2019. We determined unplanned AF-specific readmission within 30 days. Median neighborhood household income was assessed by patient zip code as quartiles: low income (Q1), middle income (Q2), upper-middle income (Q3), and high income (Q4). Differences in in-hospital cardiac procedures during the index hospitalization and probability of …
Donor Sex And Platelet Storage Change The Therapeutic Effects Of Platelet-Derived Extracellular Vesicles On Endothelium, Mandeep Kaur, Malvika Gupta, Sowmya Shree Gopal, Charles E. Wade, Jessica C. Cardenas, Amit K. Srivastava
Donor Sex And Platelet Storage Change The Therapeutic Effects Of Platelet-Derived Extracellular Vesicles On Endothelium, Mandeep Kaur, Malvika Gupta, Sowmya Shree Gopal, Charles E. Wade, Jessica C. Cardenas, Amit K. Srivastava
Cardeza Foundation for Hematologic Research
Platelet-derived extracellular vesicles (PEVs) play an active role in vascular protection and repair and are being explored as a viable alternative to platelet therapy. Because platelet function and stability are shaped by donor sex and storage conditions, these same factors are likely to influence the PEVs they release. Understanding these influences is key to developing PEVs into a safe and dependable therapeutic option. In this study, we investigated how donor sex and platelet storage affect the therapeutic properties of PEVs. To address this, PEVs were isolated from platelets of healthy male and female donors. Platelets were either processed immediately after …