Medicine and Health Sciences Commons^™

Men And Women Have Similar Responses In Arterial Stiffness And Wave Reflection Post - High - Fat Meal, C M. Weiner, E F. Blake, S E. Mascone, L E. Eagan, S M. Ranadive

International Journal of Exercise Science: Conference Proceedings

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No Impact Of Biological Sex On Cutaneous Vascular Response To 39ºc Local Heating, A C. Williams, G A. Dillon, S T. Wolf, W Larry Kenney Facsm, L M. Alexander Facsm

International Journal of Exercise Science: Conference Proceedings

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Skin Tone Representation In Kinesiology Textbook: Objective And Subjective Analysis, A L. Winger, R Creath, L A. Portzer

International Journal of Exercise Science: Conference Proceedings

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Medical French: A Practical Guide, Eric Sanfilippo, Laura Londono, Troy Mohamed

Guides

Please enjoy this pertinent medical French dictionary with over 2000 words and phrases related to medicine and healthcare translated by George Washington University medical students. Inside are 19 chapters divided by specialty that encompass anatomy, labs, diagnostics, imaging, and medical terminology specific to each system. We hope that you will find this useful when interacting with and connecting to your French-speaking patients in the clinic and hospital.

Medical School Watercooler Newsletter - June 15, 2023, Lindsey Lyle

Watercooler Newsletter

This is the June 15, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Alumni and friends celebrate 50 years of the Whiddon college of medicine
• SRFC to offer screenings June 16
• Medical students present cases at annual symposium
• Graduate students awarded dean's predoctoral fellowships

Sample Article, Sample Author

Jurnal Anestesi Perioperatif

Abstract here.

Sample Article, Sample Author

Jurnal Anestesi Perioperatif

Abstract here.

Sample Article, Sample Author

Jurnal Anestesi Perioperatif

Abstract here.

Missed And Prior Diagnoses In Children Later Diagnosed With Autism, Maire Diemer

Dissertations

Awareness of autism is rising, yet social determinants of health continue to impact rates, ages of diagnosis, and diagnostic load. Different psychiatric labels carry stigmas; unequal rates of diagnoses may indicate biases in the healthcare system. This study investigates six prior diagnoses (ADHD, disorders of conduct, adjustment, anxiety, mood, and intellectual disability) assigned to children who are later diagnosed with autism. The study investigates how race, sex, and geographic factors were associated with age of diagnosis and diagnostic load. This study utilized a sample of 13,850 children aged 2-10 who were diagnosed with autism on Missouri Medicaid between 2015 and …

Should Canada Adopt Managed Access Agreements In Canada For Expensive Drugs?, Melanie Mcphail, Tania M. Bubela

Office of the Provost

Drugs are increasingly authorized based on less mature evidence, leaving payors faced with significant clinical and cost-effectiveness uncertainties. As a result, payors must often choose between reimbursing a drug that may not turn out to be cost-effective (or may even be unsafe) or delaying the reimbursement of a drug that is cost-effective and offers clinical benefit to patients. Novel reimbursement decision models and frameworks, such as managed access agreements (MAAs), may address this decision challenge. Here, we provide a comprehensive overview of the legal limitations, considerations, and implications for adopting MAAs in Canadian jurisdictions. We begin with an overview of …

Final (Year 2) Report To Oha On Sogi Demographic Standards For Minors, Martin Arrigotti, Nell Carpenter, Kieran Chase, Alysia Cox, Itai Jeffries, Alexis Dinno

OHSU-PSU School of Public Health Faculty Publications and Presentations

Executive Summary

The report synthesizes thoughtful recommendations of the authors to the Oregon Health Authority (OHA) about routine data collection of SOGI† (sex, sexual orientation, and gender) demographic data in minors for clinical and reporting purposes. We see five primary motivations to routinely collect SOGI data, including to:

1. create an inclusive practice in order to welcome and make space for people from historically excluded genders, sexes, and sexual orientations,
2. promote health equity between minority and majority SOGI identities,
3. direct group-specific services towards those who need them,
4. represent the actual diversity of Oregon, and its communities, and
5. shift normative expectations about …

Inoculation For Neutralizing Misinformation: Replication Of An Experiment On The Effect Of The Fake Experts’ Strategy In Climate Change Communication’S Context, Joseph Abdalla

Theses and Dissertations

Low acceptance of climate change and low support for its mitigation efforts can be due to public misconceptions towards climate change. Climate skeptics use a communication strategy of fake experts to spread misinformation through spokespersons who are not experts in the field. Inoculation can be a protective approach for tackling the misinformation’s effect. Previous research was conducted in the United States and Germany and was never conducted in Africa. This study aimed to complement the previous research findings with results for Egypt by replication an experiment by Cook et al. with a 2 × 2 between-subjects design. A total of …

Incubation With Porcine Urinary Bladder Matrix Yields A Late-Stage Wound Transcriptome In Endothelial Cells And Keratinocytes Isolated From Both Diabetic And Non-Diabetic Subjects, John T. Paige, Daniel J. Lightell, Hunter F. Douglas, Natasha C. Klingenberg, Thaidan Pham, T. Cooper Woods

School of Medicine Faculty Publications

Proper wound closure requires the functional coordination of endothelial cells (ECs) and keratinocytes. In the late stages of wound healing, keratinocytes become activated and ECs promote the maturation of nascent blood vessels. In diabetes mellitus, decreased keratinocyte activation and impaired angiogenic action of ECs delay wound healing. Porcine urinary bladder matrix (UBM) improves the rate of wound healing, but the effect of exposure to UBM under diabetic conditions remains unclear. We hypothesized that keratinocytes and ECs isolated from both diabetic and non-diabetic donors would exhibit a similar transcriptome representative of the later stages of wound healing following incubation with UBM. …

A Comparative Assessment Of Approvals And Discontinuations Of Systemic Antibiotics And Other Therapeutic Areas, Rosa Rodriguez-Monguio, Enrique Seoane-Vazquez, John H. Powers Iii

Pharmacy Faculty Articles and Research

Since 1980, the US Congress has passed legislation providing several incentives to encourage the development and regulatory approval of new drugs, particularly antibiotics. We assessed long-term trends and characteristics of approvals and discontinuations of all new molecular entities, new therapeutic biologics, and gene and cell therapies approved by the US Food and Drug Administration (FDA), as well as reasons for discontinuations by therapeutic class, in the context of laws and regulations implemented over the past four decades. In the period 1980–2021, the FDA approved 1310 new drugs, of which 210 (16.0%) had been discontinued as of 31 December 2021, including …

Diagnosis Of Periprosthetic Joint Infection: The Utility Of Biomarkers In 2023, Mehmet Kursat Yilmaz, Ahmad Abbaszadeh, Saad Tarabichi, Ibrahim Azboy, Javad Parvizi

Rothman Institute Papers

Periprosthetic joint infection (PJI) is a rare yet devastating complication following total joint arthroplasty (TJA). Early and accurate diagnosis of PJI is paramount in order to maximize the chances of successful treatment. However, we are yet to identify a single “gold standard” test for the diagnosis of PJI. As a result, the diagnosis of PJI is often challenging. Currently, the 2018 ICM definition of PJI is the only validated diagnostic criteria available. This article will review the importance of serum and synovial biomarkers in the diagnosis of PJI. In addition, it will provide a brief overview of the emerging modalities …

Lifelong Fitness In Ambulatory Children And Adolescents With Cerebral Palsy Ii: Influencing The Trajectory, Susan V. Duff, Justine D. Kimbel, Marybeth Grant-Beuttler, Theresa Sukal-Moulton, Noelle G. Moreau, Kathleen M. Friel

Physical Therapy Faculty Articles and Research

Physical activity of at least moderate intensity in all children contributes to higher levels of physical and psychological health. While essential, children with cerebral palsy (CP) often lack the physical capacity, resources, and knowledge to engage in physical activity at a sufficient intensity to optimize health and well-being. Low levels of physical activity place them at risk for declining fitness and health, contributing to a sedentary lifestyle. From this perspective, we describe a framework to foster a lifelong trajectory of fitness in ambulatory children with CP (GMFCS I–III) as they progress into adolescence and adulthood, implemented in conjunction with a …

Discovery Of A Potent Highly Biased Mor Partial Agonist Among Diastereomeric C9-Hydroxyalkyl-5-Phenylmorphans., Joshua A. Lutz, Agnieszka Sulima, Eugene S. Gutman, Eric W. Bow, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Carol A. Paronis, Jack Bergman, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice

Pharmaceutical Sciences Faculty Publications

All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists. These compounds were designed to lessen the lipophilicity observed with their C9-alkenyl substituted relatives. Many of the 12 diastereomers that were obtained were found to have nanomolar or subnanomolar potency in the forskolin-induced cAMP accumulation assay. Almost all these potent compounds were fully efficacious, and three of those chosen for in vivo evaluation, 15, 21, and 36, were all extremely G-protein biased; none of the three compounds recruited beta-arrestin2. Only one of the …

Bispecific Psma Antibodies And Car-T In Metastatic Castration-Resistant Prostate Cancer., Kevin K Zarrabi, Vivek Narayan, Patrick Mille, Matthew R Zibelman, Benjamin Miron, Babar Bashir, William Kevin Kelly

Department of Medical Oncology Faculty Papers

Prostate cancer is the most common cancer among men and the second leading cause of cancer-related deaths in men in the United States. The treatment paradigm for prostate cancer has evolved with the emergence of a variety of novel therapies which have improved survival; however, treatment-related toxicities are abundant and durable responses remain rare. Immune checkpoint inhibitors have shown modest activity in a small subset of patients with prostate cancer and have not had an impact on most men with advanced disease. The discovery of prostate-specific membrane antigen (PSMA) and the understanding of its specificity to prostate cancer has identified …

Strict Conservation Yet Non-Essential Nature Of Plasmid Gene Bba40 In The Lyme Disease Spirochete Borrelia Burgdorferi, Irene N Kasumba, Kit Tilly, Tao Lin, Steven J Norris, Patricia A Rosa

Faculty, Staff and Student Publications

The highly segmented genome of Borrelia burgdorferi, the tick-borne bacterium that causes Lyme disease, is composed of a linear chromosome and more than 20 co-existing endogenous plasmids. Many plasmid-borne genes are unique to B. burgdorferi and some have been shown to provide essential functions at discrete points of the infectious cycle between a tick vector and rodent host. In this study, we investigated the role of

Neuropharmacology Of Human [Tera2.Cl.Sp12] Stem Cell-Derived Neurons In Ultra-Long-Term Culture For Antiseizure Drug Discovery, Hamed Salmanzadeh, Ankita Poojari, Atefeh Rabiee, Benjamin D. Zeitlin, Robert F. Halliwell

School of Pharmacy Faculty Articles

Modeling the complex and prolonged development of the mammalian central nervous system in vitro remains a profound challenge. Most studies of human stem cell derived neurons are conducted over days to weeks and may or may not include glia. Here we have utilized a single human pluripotent stem cell line, TERA2.cl.SP12 to derive both neurons and glial cells and determined their differentiation and functional maturation over 1 year in culture together with their ability to display epileptiform activity in response to pro-convulsant agents and to detect antiseizure drug actions. Our experiments show that these human stem cells differentiate in vitro …

Atomistic Assessment Of Drug-Phospholipid Interactions Consequent To Cancer Treatment: A Study Of Anthracycline Cardiotoxicity, Yara Elsayed Ahmed

Theses and Dissertations

Despite being one of the most effective chemotherapeutic agents developed to date, Anthracyclines are notorious for their cardiotoxicity. Their clinical use is frequently limited both in dosage and in prescription due to the severe cardiac damage they cause. The mechanism of anthracycline-induced cardiotoxicity is not yet fully understood. However, it is hypothesized that interactions with the myocardial membrane play an important role in imparting cardiotoxicity. In this study, we use molecular dynamics simulations and density functional theory calculations to study the anthracycline drug molecules and the interactions that they have with the myocardial membrane. We construct a myocardial membrane model …

Assessing The Correlation Between The Socioeconomic Level And Cognitive Function Among Older Adults In Egypt, Macy Abougabal

Theses and Dissertations

The number of older adults is increasing worldwide at an unprecedented rate. Some countries began to understand the challenges of aging, while others are still at the stage of comprehending the true dimensions of the situation. There is a global focus on aging research to appropriately mitigate the negative impact of aging and cognitive decline. Not only that dementia add economic pressure on governments, it also increase the psychological and physical burden of the caregivers. Scholars have previously studied socioeconomic level in three variables, namely work, education, and income, and their relationship with cognitive function. It was concluded that the …

Association Of Health Literacy With Demographic Features, Health-Related Behaviors, And Health Risk Indicators Among Egyptian Adults: Online Cross-Sectional Study, Rana Gamal Hassan

Theses and Dissertations

Health literacy is recognized as a significant determinant of health. Limited health literacy is a growing issue worldwide. It has a significant role facing the rising trends of non-communicable diseases (NCDs) through improving its modifiable risk factors. Therefore, studying the association between health literacy and different health-related behaviors is very important to guide both healthcare professionals and policy makers to set up the proper interventions. Our study aims to a) examine the health literacy levels among Egyptian adults, b) investigate the association of health literacy relative to socio-demographic features, health related behaviors, and self-reported health status. This is a cross-sectional …

Complement C3ar Depletion Reverses Hif-1Α-Induced Metabolic Impairment And Enhances Microglial Response To Aβ Pathology, Manasee Gedam, Michele M Comerota, Nicholas E Propson, Tao Chen, Feng Jin, Meng C Wang, Hui Zheng

Faculty, Staff and Students Publications

Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain. Using a knockin mouse line in which a Td-tomato reporter is incorporated into the endogenous C3ar1 locus, we identified 2 major subpopulations of microglia with differential C3aR expression. Expressing the Td-tomato reporter on the APPNL-G-F-knockin (APP-KI) background revealed a significant shift of microglia to a high-C3aR-expressing subpopulation and they were enriched around amyloid β (Aβ) plaques. Transcriptomic analysis of C3aR-positive microglia documented dysfunctional metabolic signatures, including upregulation of hypoxia-inducible factor 1 (HIF-1) signaling and abnormal lipid metabolism in APP-KI mice compared with wild-type controls. Using primary …

Laminectomy With Fusion Is Associated With Greater Functional Improvement Compared With Laminectomy Alone For The Treatment Of Degenerative Lumbar Spondylolisthesis: A Systematic Review And Meta-Analysis, Geet Shukla, Sai S. Chilakapati, Abhijith V. Matur, Paolo Palmisciano, Fatu Conteh, Louisa Onyewadume, Henry Ofori Duah, Azante Griffith, Xu Tao, Phillip Vorster, Sahil Gupta, Joseph Cheng, Benjamin Motley, Owoicho Adogwa

College of Nursing Faculty Research and Publications

Study Design.  Systematic review and Meta-analysis. Objective.  To compare outcomes and complications profile of laminectomy alone versus laminectomy and fusion for the treatment of degenerative lumbar spondylolisthesis (DLS). Summary of Background Data.  Degenerative lumbar spondylolisthesis is a common cause of back pain and functional impairment. DLS is associated with high monetary (up to $100 billion annually in the US) and nonmonetary societal and personal costs. While nonoperative management remains the first-line treatment for DLS, decompressive laminectomy with or without fusion is indicated for the treatment-resistant disease. Methods.  We systematically searched PubMed and EMBASE for RCTs and cohort studies from inception …

Shared Care Networks Assisting Older Adults: New Insights From The National Health And Aging Trends Study, Mengyao Hu, Vicki A Freedman, Sarah E Patterson, Nora Lewis

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVES: Caregiving research often assumes older adults receiving care have a primary caregiver who provides the bulk of care. Consequently, little is known about the extent to which care responsibilities are shared more evenly within a care network, the characteristics associated with sharing, or the consequences for meeting older adults' care needs.

RESEARCH DESIGN AND METHODS: We analyze a sample of U.S. older adults receiving care from the 2011 National Health and Aging Trends Study (n = 2,398). Based on variables reflecting differences in care hours, activities, and care provided by the whole network, we create network typologies …

Colocalization Of Linezolid Resistance (Cfr) And Virulence Factors Cytolysin And Hemolysin (Cln And Hln) On A Plasmid In Enterococcus Faecalis, Nikita V Singh, Kavindra V Singh, An Q Dinh, Cesar A Arias, William C Shropshire, Blake M Hanson, Barbara E Murray

Faculty, Staff and Student Publications

No abstract provided.

Initial Understanding Of Public Stigma Against Childhood Cancer Survivors, Nele Loecher

USF Tampa Graduate Theses and Dissertations

As childhood cancer survival rates climb to new records, it is increasingly important to focus on improving the psychological wellbeing of survivors living years beyond their diagnosis. One potential contributor to psychological distress for childhood cancer survivors (CCSs) is stigma. The fear of stigma can lead to CCSs concealing their identity as a CCS, which in turn can strain workplace and intimate relationships, creating a strain on CCSs’ social and work life. Additionally, the internalization of negative stereotypes or rejection of falsely positive stereotypes around cancer can exacerbate psychological distress. To establish what stereotypes and stigma CCS might be contending …

Evolutionary And Functional History Of The Escherichia Coli K1 Capsule., Sergio Arredondo-Alonso, George Blundell-Hunter, Zuyi Fu, Rebecca A. Gladstone, Alfred Fillol-Salom, Jessica Loraine, Elaine Cloutman-Green, Pål J. Johnsen, Ørjan Samuelsen, Anna K. Pöntinen, François Cléon, Susana Chavez-Bueno, Miguel A. De La Cruz, Miguel A. Ares, Manivanh Vongsouvath, Agnieszka Chmielarczyk, Carolyne Horner, Nigel Klein, Alan Mcnally, Joice N. Reis, José R. Penadés, Nicholas R. Thomson, Jukka Corander, Peter W. Taylor, Alex J. Mccarthy

Manuscripts, Articles, Book Chapters and Other Papers

Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, which is fundamental to elucidating its role in the expansion of successful lineages. Using systematic surveys of invasive E. coli isolates, we show that the K1-cps locus is present in a quarter of bloodstream infection isolates and has emerged …

Variability Of Air Sampling Results Using Air-O-Cell Cassettes, Christina M. Haworth

USF Tampa Graduate Theses and Dissertations

No current federal or state standards for mold exposure exist, partly due to the lack of accurate methods for assessing fungal exposure. Exposure to airborne fungal spores can result in several symptoms such as allergic rhinitis, coughing, and fatigue. Non-industrial occupational settings are common and fungal exposures may occur in these environments. The purpose of this study is to evaluate the meaningfulness of fungal spore trap results from samples collected in both a corporate office and a university classroom. Air-O-Cell cassettes with a Zefon Bio-Pump were used to collect one outdoor and three indoor samples at each location on three …