Medicine and Health Sciences Commons^™

Self-Efficacy With Telehealth Examination: The Doctor Of Physical Therapy Student Perspective, Derrick F. Campbell, Jean-Michel Brismee, Brad Allen, Troy Hooper, Manuel A. Domenech, Kathleen J. Manella

Philippine Journal of Physical Therapy

Introduction: The shift to telehealth exposed gaps in our understanding of how physical therapy students perceive patient assessment in a remote situation using the examination component of the patient/client management (PCM) model. The purpose of the study was to compare Doctor of Physical Therapy (DPT) students’ self-efficacy performing patient assessment using the examination component of the PCM model using telehealth compared with conventional examination. To achieve the purpose of this study, the Physical Therapist Self-Efficacy (PTSE) scale was used. More specifically, self-efficacy in clinical reasoning was measured using the following items: (1) PTSE total score (2) performance of tests …

Effectiveness Of Using Exercise App In Improving Exercise Adherence And Aerobic Endurance Of Football Players, Cheryll D.N.N. Obra, Agatha C.S. Quidilla, Rome J. Cajigal, Jannah K.A. Jerez, Shiela M.A. Ramos, Reyma J.C. Malabed

Philippine Journal of Physical Therapy

Introduction. The use of mobile apps known as mHealth is starting to shape the delivery of physical therapy care not only in patients but also to the healthy population. Using an exercise app is a potential strategy to promote physical activity among individuals. Thus, this pilot study examined the utility of the Nike® Training Club app in increasing exercise adherence and enhancing aerobic endurance.

Methods. The study utilized one-way repeated measures over time quasi-experimental design. It used purposive sampling to select 10 college football players aged 18-25 years old. After downloading the app, the participants were required to perform a …

Healthy Eating And Physical Activity: Analysing Soweto’S Young Adults’ Perspectives With An Intersectionality Lens, Gudani Mukoma, Edna Bosire, Sonja Klingberg, Shane A. Norris

Brain and Mind Institute

Background and objectives: Non-communicable diseases (NCDs) are taking a toll on Africa’s youth at younger ages than in other regions. These are attributed to risk factors that usually advance in adolescence, such as unhealthy diets and reduced physical activity. Young adults in South Africa, particularly women, tend to be sedentary, consume energy-dense diets low in micronutrients, and are more likely to develop NCDs much earlier in life than those in high-income countries. With an intersectionality perspective, this study explored young adults’ barriers and solutions to addressing these risk factors in Soweto.

Setting: Soweto, Johannesburg, South Africa, is one …

Assessment Of Ongoing Challenges With The Parental Nutrition Ordering Processes Within The Lehigh Valley Health Network, Victoria Rosado, Kimberly Cephas Ms, Rd, Cnsc, Rachael Geosits Ms, Rdn, Cnsc, Ldn, Courtney Kalamar Rd, Cnsc, Ldn, Melissa Faura Rd, Ldn, Ann Flickinger Ms, Rd, Ldn

Research Scholars

No abstract provided.

Functional Ability And Quality Of Life Of Adult Patients With Hearing Loss: A Cross-Sectional Study, Shalini Saligrama, Soumya Christabel Dr., Jomon C U

Manipal Journal of Nursing and Health Sciences

Background and aim: The loss of hearing becomes precious when it is lacking, which makes it valuable. Hearing loss commonly affects functional ability and quality of life (QoL). Assessing the QoL in individuals with hearing loss helps with interventions and modifications of life habits. Objectives: The purpose of this study was to assess the functional ability and QoL of adult patients with hearing loss and to find the correlation between functional ability and QoL. Materials and methods: Adult patients (132) aged between 19 and 70 were chosen, all experiencing sensorineural, conductive, or mixed hearing impairments ranging from moderate to …

The Effect Of Visual Feedback On Vocal Compensation Abilities In Individuals With Post-Stroke Aphasia, Marissa Rylee Olson

Theses and Dissertations

Speech production is a complex and highly organized process comprised of various sensory and perceptual components. Post-stroke aphasia can impair speech production abilities by interrupting individuals’ ability to detect and correct speech errors and produce their targeted behavior. Contemporary models of speech production aim to understand the relationship between sensory systems and the human ability to produce perceptually accurate speech. This study seeks to understand the relationship between visual feedback and vocal compensation abilities in individuals with post-stroke aphasia to determine the effectiveness of incorporating visual feedback into therapeutic expressive language intervention. It was hypothesized that that the multi-sensory experimental …

Posture Care Management In School Based Settings For Children With Complex Physical Disabilities, Sabrina Rodriguez, Mary Jan Greer, Lee Ann Hoffman

Summer 2023 Virtual OTD Capstone Symposium

Posture care management (PCM) is an intervention that helps protect a person’s body through different positions within different contexts. PCM is not a singular direct intervention as each person is different and has different needs. This process is especially important for those who cannot reposition themselves such as children with complex physical disabilities. These children rely mainly for caregivers and school staff this process since home and school are the main places they spend the beginning years of their lives. Therefore, it is important to educate caregivers and school staff on the guidelines of proper PCM to promote health, well-being, …

Occupational Therapists' Perceptions Of Sensory Processing Evaluation Methods, Grace Hong, Jazminne Orozco Arteaga, Karen Park

Summer 2023 Virtual OTD Capstone Symposium

Background: This study aimed to obtain occupational therapists’ (OTs) experiences and perspectives on current evaluation tools who work with clients with sensory processing challenges in their clinical settings. Method: This research was a mixed-method study. Data was collected from surveys (n = 11) which had a mix of nominal, interval, close-ended, and open-ended questions. Following survey completion, participants were given the option to complete a semi-structured interview (n = 2) consisting of open-ended questions to clarify survey responses and gather additional information about their experiences. Results: The results indicated a high number of various barriers and limitations …

Plan For Retirement Versus The Occupational Impact Throughout Retirement: The Significance Of Identity And Role Transitions, Priscilla Guardado, Amy Lyons-Brown

Summer 2023 Virtual OTD Capstone Symposium

OBJECTIVE: The purpose of this study was to conduct a mixed methods research study on retired individuals and identifying their occupational identity throughout their retired experience.

METHODS: Using survey methods, a demographic questionnaire was sent out to individuals who signed up to participate in the study. To participate, individuals had to be in the age range of 50-80 years with a minimum of 2 years post retirement. A total of 15 participants initially signed up with a 93% survey response rate (n=14) and 86% (n=13) response rate for completion of the study with an interview.

RESULTS: Most participants reported dealing …

The Occupational Impacts That Sexual Assault Has On Female College Students, Breannah Scheiderman, Amy Lyons-Brown

Summer 2023 Virtual OTD Capstone Symposium

This mixed methods study outlines some of the occupational impacts that sexual assault has on female college students. Data was collected by both a survey and personal testimonies from readily available experiences. This paper introduces the problem and some things that can be done from an occupational therapy perspective.

Advanced Prognostic Modeling For Breast Cancer Patients: Leveraging Data-Driven Approaches For Survival Analysis, Theophilus Gyedu Baidoo

Theses and Dissertations

Breast cancer is the second most prevalent form of cancer in women in the United States. Each year, about 264,000 cases of breast cancer are diagnosed in women and of this number, about 42,000 women lose their lives as reported by the Centers for Disease Control and Prevention. Early detection and effective treatment are crucial for improving survival rates and reducing mortality. This study aimed to explore the influential factors that may risk the survival of women with the disease and compare their predictive abilities using several error and performance metrics. The study uses a dataset from the National Cancer …

Neural Mechanisms Related To The Enhanced Auditory Selective Attention Following Neurofeedback Training: Focusing On Cortical Oscillations, Hwan Shim, Leah Gibbs, Karsyn Rush, Jusung Ham, Subong Kim, Sungyoung Kim, Inyong Choi

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Selective attention can be a useful tactic for speech-in-noise (SiN) interpretation as it strengthens cortical responses to attended sensory inputs while suppressing others. This cortical process is referred to as attentional modulation. Our earlier study showed that a neurofeedback training paradigm was effective for improving the attentional modulation of cortical auditory evoked responses. However, it was unclear how such neurofeedback training improved attentional modulation. This paper attempts to unveil what neural mechanisms underlie strengthened auditory selective attention during the neurofeedback training paradigm. Our EEG time–frequency analysis found that, when spatial auditory attention was focused, a fronto-parietal brain network was activated. …

Etiologies And Predictors Of 30-Day Readmission In Heart Failure: An Updated Analysis, Akhil Jain, Shilpkumar Arora, Viral Patel, Maharshi Raval, Karnav Modi, Nirav Arora, Rupak Desai, Behnam Bozorgnia, Raphael Bonita

Einstein Health Papers

BACKGROUND AND OBJECTIVES: Readmissions in heart failure (HF), historically reported as 20%, contribute to significant patient morbidity and high financial cost to the healthcare system. The changing population landscape and risk factor dynamics mandate periodic epidemiologic reassessment of HF readmissions.

METHODS: National Readmission Database (NRD, 2019) was used to identify HF-related hospitalizations and evaluated for demographic, admission characteristics, and comorbidity differences between patients readmitted vs. those not readmitted at 30-days. Causes of readmission and predictors of all-cause, HF-specific, and non-HF-related readmissions were analyzed.

RESULTS: Of 48,971 HF patients, the readmitted cohort was younger (mean 67.4 vs. 68.9 years, p≤0.001), had …

A Dynamical Systems Approach To Characterizing Brain–Body Interactions During Movement: Challenges, Interpretations, And Recommendations, Derek C. Monroe, Nathaniel T. Berry, Peter C. Fino, Christopher K. Rhea

Rehabilitation Sciences Faculty Publications

Brain–body interactions (BBIs) have been the focus of intense scrutiny since the inception of the scientific method, playing a foundational role in the earliest debates over the philosophy of science. Contemporary investigations of BBIs to elucidate the neural principles of motor control have benefited from advances in neuroimaging, device engineering, and signal processing. However, these studies generally suffer from two major limitations. First, they rely on interpretations of ‘brain’ activity that are behavioral in nature, rather than neuroanatomical or biophysical. Second, they employ methodological approaches that are inconsistent with a dynamical systems approach to neuromotor control. These limitations represent a …

Pregnancy In United States Immigration Detention: Listening To Migrant Women's Stories, Amanda Heffernan

Nursing ETDs

Over the last five years, dramatic shifts in immigration policy across three presidential administrations have impacted migrants arriving at the U.S.’ southern border, with unique impacts on pregnant migrants. The purpose of this study was to document, analyze and contextualize the experience of pregnancy in United States immigration detention. Specifically, the study aimed to: 1) understand the situation of pregnant migrants detained in United States immigration detention facilities between 2017-2022; 2) situate the experience of detained pregnant migrants within multiple contexts, including their own individual and family migration stories and the larger context of United States immigration policy; and 3) …

2023-2024 Pediatric Subspecialty Trainees, Children's Mercy Kansas City

Residents and Fellows Portraits

Photo composites of the graduate pediatric trainees in adolescent medicine, allergy/immunology, child abuse pediatrics, child neurology, clinical neuro-psychology, coagulation, clinical child psychology, clinical child psychology internship, epilepsy, hospice & palliative care, pediatric anesthesiology, pediatric bioethics, neonatal-perinatal medicine, pediatric adolescent gynecology, pediatric cardiology, pediatric EM/child abuse, pediatric critical care medicine, pediatric dentistry, pediatric emergency medicine, pediatric endocrinology, pediatric gastroenterology, pediatric hematology/oncology, pediatric hospital medicine, pediatric infectious diseases, pediatric nephrology, pediatric ophthalmology; pediatric optometry, pediatric orthopedic surgery, pediatric otolaryngology, pediatric pulmonology, pediatric rehabilitation, pediatric sports medicine, pediatric surgery, sleep medicine, pharmacy, pediatric residency and med/peds residency.

The Effect Of Two Sintering Cycles And Aging On Biaxial Flexural Strength Of Strength Gradient Multi-Layered Zirconia (An Vitro Study), Passent Hm El Galab, Maged Zohdy, Fatma Makkeyah, Mustafa Noor

Dentistry

No abstract provided.

Fast Inference Of Genetic Recombination Rates In Biobank Scale Data, Ardalan Naseri, William Yue, Shaojie Zhang, Degui Zhi

Faculty, Staff and Student Publications

Although rates of recombination events across the genome (genetic maps) are fundamental to genetic research, the majority of current studies only use one standard map. There is evidence suggesting population differences in genetic maps, and thus estimating population-specific maps, are of interest. Although the recent availability of biobank-scale data offers such opportunities, current methods are not efficient at leveraging very large sample sizes. The most accurate methods are still linkage disequilibrium (LD)-based methods that are only tractable for a few hundred samples. In this work, we propose a fast and memory-efficient method for estimating genetic maps from population genotyping data. …

Initiating A Childhood Obesity Screening Process In An Urban Pediatric Office, Kesha Thomas

Doctor of Nursing Practice Projects

Background: The benefit of identifying a pediatric patient with obesity is to prevent many chronic health conditions that can occur from diabetes. Pediatric patients can be at risk for prediabetes, low self-esteem, and musculoskeletal issues. The patients that are at higher risk for childhood obesity are African American and Hispanics.

Purpose: The Doctor of Nursing Practice project aims to identify a pediatric patient that is obese to make sure that the patient is assessed appropriately and to discuss an appropriate intervention for the patient. To make sure all pediatrics have an accurate height, weight, and A1C during their well-child visit. …

The Implementation Of The Pressure Injury Prevention Protocol To Reduce The Incidence Of Hospital-Acquired Pressure Injuries In A Va Medical Surgical Unit, Nekia Whitlow

Doctor of Nursing Practice Projects

Background: The clinical gap in service addressed in the DNP project was hospital-acquired pressure injuries. A hospital-acquired pressure injury (HAPI) is a local injury to the skin and underlying tissue during an inpatient hospital stay. The injury is caused by pressure, shear, or both (The Joint Commission (TJC), 2022). The development of a HAPI can result from other factors, such as advanced age, immobility, perfusion issues, nutritional status, illness severity, and chronic conditions (Rondinelli, Zuniga, Kipnis, et al., 2018). Immobile or sedated patients in the intensive care units are the most at risk because they have medical conditions that prevent …

Maxillary And Mandibular Incisor And Molar Dentoalveolar Heights In Untreated Subjects Presenting Class I And Class Ii Malocclusion, Samantha Zavada Cardinal

Master's Theses (2009 -)

Objective : Class II malocclusion has been extensively studied, however there are many unanswered questions. This study analyzed the difference in incisor and molar dentoalveolar heights of untreated subjects presenting with Class I and Class II malocclusion. Dentialveolar heights are an aspect of the craniofacial complex that changes with growth and development and are manipulated by orthodontists. These changes hold important clinical implications for the development, maintenance and treatment of malocclusions. Methods : A sample of 96 untreated Class I and Class II subjects, with a total of 611 cephalograms was drawn from the archives of the University of Michigan …

Alveolar Bone Remodeling In Response To Orthodontic Tooth Movement, Matthew Raymond Mcgrady

Master's Theses (2009 -)

Objective: Dental protrusion and retrusion are common malocclusions in clinical orthodontics. When teeth are moved orthodontically, the alveolar bone surrounding the teeth remodels. In the past, incisor retraction-associated alveolar bone remodeling has been studied. However, less is known about the alveolar bone remodeling after incisors are proclined. This study aimed to assess the changes in alveolar bone thickness after proclination of maxillary incisors. The null hypothesis was that there is no difference in the surrounding alveolar bone thickness after orthodontic tooth movement. Materials and Methods: Patients were selected under the inclusion criteria of moderate-to-severe bimaxillary dental retrusion (U1-SN < 97°, L1-MP < 88.0°), absence of craniofacial anomalies, non-extraction, absence of missing teeth, with quality pre-and post-treatment lateral cephalometric images. Nineteen patients (10 males, 9 females; mean age 14.7 years) were selected, and their pre-treatment and post-treatment lateral cephalograms were digitally traced using a customized cephalometric analysis to compare changes in labial and lingual alveolar bone thickness (ABT) after orthodontic treatment. A two-sample t-test with R statistical software version 4.1.2 was used to measure the differences between the pre- and post-treatment cephalometric measurements. A p value less than 0.05 was considered statistically significant. Results: According to the SN-7° measurement method, ABT increased at the labial(b) SN-7 (0.27mm ± 0.70; p<0.05) and U1 labial(c) SN-7 (0.79mm ± 1.56; p<0.05) levels; however, ABT decreased at the U1 lingual (c) SN-7 (1.13mm ± 1.35; p<0.05) level. According to the perpendicular of the long axis of U1 root measurement method, ABT increased at the U1 labial(c) ⊥U1 (0.55mm ± 1.35; p<0.05) level while ABT decreased at the U1 lingual (b) ⊥U1 (0.79mm ± 1.03; p<0.05) and U1 lingual (c) ⊥U1 (1.61mm ±1.39; p<0.05) levels. Statistically significant changes were also found in post-treatment incisor angulation U1-SN° (8.05° ± 8.25; p<0.05), U1 – NA° (7.44° ± 8.08; p < 0.05) and post-treatment incisor position U1 – NA (mm) (1.64mm ± 2.63; p<0.05). Conclusion:The null hypothesis was rejected based on our results. There are statistically significant changes to the labial and lingual alveolar bone (ABT) after proclination of the maxillary incisors. Our data support previous findings in orthodontics literature. Further studies should be conducted that can employ larger sample sizes with imaging methods that overcome the limitations of conventional two-dimensional imaging.

Short And Long-Term Effects Of Conventional And Miniscrew-Assisted Rapid Palatal Expansion On Hard Tissues Using Voxel-Based Superimposition Of Serial Cbcts, Isaac R. Empson

Master's Theses (2009 -)

Objective: The objective of this study was to evaluate the short-term and long-term hard tissue changes with miniscrew-assisted rapid palatal expansion (MARPE) and rapid palatal expansion (RPE) compared to a matched control group with voxel based superimposition and three dimensional cone-beam computed tomography (CBCT) analysis. Methods:After IRB review, a total of 180 cone beam computed tomography (CBCT) scans were analyzed for 60 patients with a mean age of 13.9 years at 3 time points: pretreatment (T1), Post-Expansion (T2), and Post-treatment (T3). Patients were divided into 3 groups: MARPE, RPE, and controls. Voxel-based superimposition was performed for CBCTs from T1 to …

The Decline Of Physical Activity With Age In School-Aged Children With Cerebral Palsy: A Single-Center Cross-Sectional Observational Study, Jinuk Lee, Min-Hwa Suk, Soojin Yoo, Jeong-Yi Kwon

Health & Human Performance Faculty Publications

Maintaining physical activity is important for children with cerebral palsy (CP). This study examined whether age predicted habitual physical activity (HPA) or cardiorespiratory fitness (CRF) in school-aged children with CP and clarified the relationship between HPA and CRF. We utilized cross-sectional data from 39 children with CP (18 girls and 21 boys; mean age 7.44 years; mean body weight 24.76 kg; mean body mass index 15.97 kg/m2; hemiplegic or diplegic CP). The participants wore an accelerometer (ActiGraph) for five days to measure HPA, physical activity energy expenditure (kcal/kg/d), sedentary physical activity (%SPA), light physical activity, moderate-to-vigorous physical activity (%MVPA), and …

Hippocampal Volume And The Detection Of Mild Cognitive Impairment In An Older Adult Population: Assessing Performance On Cognitive Screeners Administered In-Person And Electronically, Kristen Fabrizi

Dissertations

The present study investigated how performance on in-person and electronic neuropsychological assessment measures predicted subcortical hippocampal volume and cognitive decline consistent with mild cognitive impairment. It was hypothesized that the Montreal Cognitive Assessment would display better predictive strength than the Cogstate Brief Battery when evaluating subcortical hippocampal volume measured via structural magnetic resonance imaging. It was further hypothesized that the Montreal Cognitive Assessment would be more sensitive to predicting group membership to the diagnostic classification of mild cognitive impairment compared to the Cogstate Brief Battery. The sample included 445 older adult participants selected from the Alzheimer’s Disease Neuroimaging Initiative 3. …

Associations Between Kir/Kir-Ligand Genotypes And Clinical Outcome For Patients With Advanced Solid Tumors Receiving Bempeg Plus Nivolumab Combination Therapy In The Pivot-02 Trial, A S Feils, A K Erbe, J Birstler, K Kim, U Hoch, S L Currie, T Nguyen, D Yu, A O Siefker-Radtke, N Tannir, S M Tolaney, A Diab, P M Sondel

Faculty, Staff and Student Publications

Bempegaldesleukin (BEMPEG), a CD122-preferential IL2 pathway agonist, has been shown to induce proliferation and activation of NK cells. NK activation is dependent on the balance of inhibitory and excitatory signals transmitted by NK receptors, including Fc-gamma receptors (FCγRs) and killer immunoglobulin-like receptors (KIRs) along with their KIR-ligands. The repertoire of KIRs/KIR-ligands an individual inherits and the single-nucleotide polymorphisms (SNPs) of FCγRs can influence NK function and affect responses to immunotherapies. In this retrospective analysis of the single-arm PIVOT-02 trial, 200 patients with advanced solid tumors were genotyped for KIR/KIR-ligand gene status and FCγR SNP status and evaluated for associations with …

Dna Methylation-Based Classifier Differentiates Intrahepatic Pancreato-Biliary Tumours, Mihnea P Dragomir, Teodor G Calina, Eilís Perez, Simon Schallenberg, Meng Chen, Thomas Albrecht, Ines Koch, Peggy Wolkenstein, Benjamin Goeppert, Stephanie Roessler, George A Calin, Christine Sers, David Horst, Florian Roßner, David Capper

Faculty, Staff and Student Publications

BACKGROUND: Differentiating intrahepatic cholangiocarcinomas (iCCA) from hepatic metastases of pancreatic ductal adenocarcinoma (PAAD) is challenging. Both tumours have similar morphological and immunohistochemical pattern and share multiple driver mutations. We hypothesised that DNA methylation-based machine-learning algorithms may help perform this task.

METHODS: We assembled genome-wide DNA methylation data for iCCA (n = 259), PAAD (n = 431), and normal bile duct (n = 70) from publicly available sources. We split this cohort into a reference (n = 399) and a validation set (n = 361). Using the reference cohort, we trained three machine learning models to differentiate between these entities. Furthermore, …

Multi-Task Learning With Dynamic Re-Weighting To Achieve Fairness In Healthcare Predictive Modeling, Can Li, Sirui Ding, Na Zou, Xia Hu, Xiaoqian Jiang, Kai Zhang

Faculty, Staff and Student Publications

The emphasis on fairness in predictive healthcare modeling has increased in popularity as an approach for overcoming biases in automated decision-making systems. The aim is to guarantee that sensitive characteristics like gender, race, and ethnicity do not influence prediction outputs. Numerous algorithmic strategies have been proposed to reduce bias in prediction results, mitigate prejudice toward minority groups and promote prediction fairness. The goal of these strategies is to ensure that model prediction performance does not exhibit significant disparity among sensitive groups. In this study, we propose a novel fairness-achieving scheme based on multitask learning, which fundamentally differs from conventional fairness-achieving …

Predicting Benefit From Immune Checkpoint Inhibitors In Patients With Non-Small-Cell Lung Cancer By Ct-Based Ensemble Deep Learning: A Retrospective Study, Maliazurina B Saad, Lingzhi Hong, Muhammad Aminu, Natalie I Vokes, Pingjun Chen, Morteza Salehjahromi, Kang Qin, Sheeba J Sujit, Xuetao Lu, Elliana Young, Qasem Al-Tashi, Rizwan Qureshi, Carol C Wu, Brett W Carter, Steven H Lin, Percy P Lee, Saumil Gandhi, Joe Y Chang, Ruijiang Li, Michael F Gensheimer, Heather A Wakelee, Joel W Neal, Hyun-Sung Lee, Chao Cheng, Vamsidhar Velcheti, Yanyan Lou, Milena Petranovic, Waree Rinsurongkawong, Xiuning Le, Vadeerat Rinsurongkawong, Amy Spelman, Yasir Y Elamin, Marcelo V Negrao, Ferdinandos Skoulidis, Carl M Gay, Tina Cascone, Mara B Antonoff, Boris Sepesi, Jeff Lewis, Ignacio I Wistuba, John D Hazle, Caroline Chung, David Jaffray, Don L Gibbons, Ara Vaporciyan, J Jack Lee, John V Heymach, Jianjun Zhang, Jia Wu

Faculty, Staff and Student Publications

BACKGROUND: Only around 20-30% of patients with non-small-cell lung cancer (NCSLC) have durable benefit from immune-checkpoint inhibitors. Although tissue-based biomarkers (eg, PD-L1) are limited by suboptimal performance, tissue availability, and tumour heterogeneity, radiographic images might holistically capture the underlying cancer biology. We aimed to investigate the application of deep learning on chest CT scans to derive an imaging signature of response to immune checkpoint inhibitors and evaluate its added value in the clinical context.

METHODS: In this retrospective modelling study, 976 patients with metastatic, EGFR/ALK negative NSCLC treated with immune checkpoint inhibitors at MD Anderson and Stanford were enrolled from …

Radiomic And Deep Learning Characterization Of Breast Parenchyma On Full Field Digital Mammograms And Specimen Radiographs: A Pilot Study Of A Potential Cancer Field Effect, Natalie Baughan, Hui Li, Li Lan, Matthew Embury, Isaiah Yim, Gary J Whitman, Randa El-Zein, Isabelle Bedrosian, Maryellen L Giger

Faculty, Staff and Student Publications

PURPOSE: In women with biopsy-proven breast cancer, histologically normal areas of the parenchyma have shown molecular similarity to the tumor, supporting a potential cancer field effect. The purpose of this work was to investigate relationships of human-engineered radiomic and deep learning features between regions across the breast in mammographic parenchymal patterns and specimen radiographs.

APPROACH: This study included mammograms from 74 patients with at least 1 identified malignant tumor, of whom 32 also possessed intraoperative radiographs of mastectomy specimens. Mammograms were acquired with a Hologic system and specimen radiographs were acquired with a Fujifilm imaging system. All images were retrospectively …