Medicine and Health Sciences Commons^™

Open Repair Of An Infected Abdominal Aortic Aneurysm In A Patient With Vascular Ehlers-Danlos Syndrome, Bernardo C Mendes, Diego V S Rodrigues, Indrani Sen, Juan Bowen, Gustavo S Oderich

Faculty, Staff and Student Publications

No abstract provided.

Perioperative Team-Based Morbidity And Mortality Conferences: A Systematic Review Of The Literature, Aubrey Samost-Williams, Roni Rosen, Alexander Hannenberg, Melis Lydston, Garrett M Nash, Mary Brindle

Faculty, Staff and Student Publications

OBJECTIVE: This systematic review aimed to identify key elements of perioperative team-based morbidity and mortality conferences (TBMMs) and their impact on patient safety, education, and quality improvement outcomes.

BACKGROUND: Patient safety in the perioperative period is influenced by system, team, and individual behaviors. However, despite this recognition, single-discipline morbidity and mortality conferences remain a mainstay of educational and quality improvement efforts.

METHODS: A structured search was conducted in MEDLINE Complete, Embase, Web of Science, ClinicalTrials.gov, Cochrane CENTRAL, and ProQuest Dissertations and Theses Global in July 2022. Search results were screened, and the articles meeting inclusion criteria were abstracted.

RESULTS: Seven …

Understanding Ip3r Channels: From Structural Underpinnings To Ligand-Dependent Conformational Landscape, Mariah R Baker, Guizhen Fan, Vikas Arige, David I Yule, Irina I Serysheva

Faculty, Staff and Student Publications

Inositol 1,4,5-trisphosphate receptors (IP3Rs) are ubiquitously expressed large-conductance Ca2+-permeable channels predominantly localized to the endoplasmic reticulum (ER) membranes of virtually all eukaryotic cell types. IP3Rs work as Ca2+ signaling hubs through which diverse extracellular stimuli and intracellular inputs are processed and then integrated to result in delivery of Ca2+ from the ER lumen to generate cytosolic Ca2+ signals with precise temporal and spatial properties. IP3R-mediated Ca2+ signals control a vast repertoire of cellular functions ranging from gene transcription and secretion to the more enigmatic brain activities such as learning and memory. IP3Rs open and release Ca2+ when they bind both …

Rapidly Progressing Autoimmune Hemolytic Anemia In A Pediatric Patient With Covid-19., Julia E. Kononowicz, M. Farhan Ali, William Palko, Sean Pyper, Nisha Agasthya

Manuscripts, Articles, Book Chapters and Other Papers

SARS-CoV-2 is a novel virus that is known to have a predilection for complications associated with the respiratory system. Although COVID-19 has a wide spectrum of manifestations, the pathophysiology of severe illness remains poorly understood but is thought to be associated with fulminant cytokine release. While severe complications secondary to COVID-19 in the pediatric population are considered rare, they do happen. Children with and without comorbidities have required intensive care unit admissions for respiratory distress and, more notably, multisystem inflammatory syndrome in children (MIS-C). While MIS-C is associated with hematologic complications, such as thrombocytopenia and coagulopathies, it is not associated …

Zranb1 Is An Nbs1 Deubiquitinase And A Potential Target To Overcome Radioresistance And Parp Inhibitor Resistance In Triple-Negative Breast Cancer, Ying Mei, Qinglei Hang, Hongqi Teng, Fan Yao, Mei-Kuang Chen, Mien-Chie Hung, Yutong Sun, Li Ma

Faculty, Staff and Student Publications

No abstract provided.

Differentiating Urgent From Elective Cases Matters In Minority Populations: Developing An Ordinal "Desirability Of Outcome Ranking" To Increase Granularity And Sensitivity Of Surgical Outcomes Assessment, Michael A Jacobs, Susanne Schmidt, Daniel E Hall, Karyn B Stitzenberg, Lillian S Kao, Chen-Pin Wang, Laura S Manuel, Paula K Shireman

Faculty, Staff and Student Publications

BACKGROUND: Surgical analyses often focus on single or binary outcomes; we developed an ordinal Desirability of Outcome Ranking (DOOR) for surgery to increase granularity and sensitivity of surgical outcome assessments. Many studies also combine elective and urgent procedures for risk adjustment. We used DOOR to examine complex associations of race/ethnicity and presentation acuity.

STUDY DESIGN: NSQIP (2013 to 2019) cohort study assessing DOOR outcomes across race/ethnicity groups risk-adjusted for frailty, operative stress, preoperative acute serious conditions, and elective, urgent, and emergent cases.

RESULTS: The cohort included 1,597,199 elective, 340,350 urgent, and 185,073 emergent cases with patient mean age of 60.0 …

Inorganic Fertilizer Use And Its Association With Rice Yield Gaps In Sub-Saharan Africa, Jean-Martial Johnson, Ali Ibrahim, Elliott Ronald Dossou-Yovo, Kalimuthu Senthilkumar, Yasuhiro Tsujimoto, Hidetoshi Asai, Kazuki Saito

Faculty, Staff and Student Publications

Where and which countries should receive higher priority for improving inorganic fertilizer use in rice fields in sub-Saharan Africa (SSA)? This study addressed this question by assessing the spatial variation in fertilizer use and its association with rice yield and yield gap in 24 SSA countries through a systematic literature review of peer-reviewed papers, theses, and grey literature published between 1995 and 2021. The results showed a large variation in N, P, and K fertilizer application rates and rice yield and an opportunity for narrowing the yield gap by increasing N and P rates, especially in irrigated rice systems. We …

Low Pitch Significantly Reduces Helical Artifacts In Abdominal Ct, Moiz Ahmad, Peng Sun, Christine B Peterson, Marcus R Anderson, Xinming Liu, Ajaykumar C Morani, Corey T Jensen

Faculty, Staff and Student Publications

Purpose: High helical pitch scanning minimizes scan times in CT imaging, and thus also minimizes motion artifact and mis-synchronization with contrast bolus. However, high pitch produces helical artifacts that may adversely affect diagnostic image quality. This study aims to determine the severity and incidence of helical artifacts in abdominal CT imaging and their relation to the helical pitch scan parameter.

Methods: To obtain a dataset with varying pitch values, we used CT exam data both internal and external to our center. A cohort of 59 consecutive adult patients receiving an abdomen CT examination at our center with an accompanying prior …

Rare Variants In Ano1, Encoding A Calcium-Activated Chloride Channel, Predispose To Moyamoya Disease, Amélie Pinard, Wenlei Ye, Stuart M Fraser, Jill A Rosenfeld, Pavel Pichurin, Scott E Hickey, Dongchuan Guo, Alana C Cecchi, Maura L Boerio, Stéphanie Guey, Chaker Aloui, Kwanghyuk Lee, Markus Kraemer, Saleh Omar Alyemni, Michael J Bamshad, Deborah A Nickerson, Elisabeth Tournier-Lasserve, Shozeb Haider, Sheng Chih Jin, Edward R Smith, Kristopher T Kahle, Lily Yeh Jan, Mu He, Dianna M Milewicz

Faculty, Staff and Student Publications

Moyamoya disease, a cerebrovascular disease leading to strokes in children and young adults, is characterized by progressive occlusion of the distal internal carotid arteries and the formation of collateral vessels. Altered genes play a prominent role in the aetiology of moyamoya disease, but a causative gene is not identified in the majority of cases. Exome sequencing data from 151 individuals from 84 unsolved families were analysed to identify further genes for moyamoya disease, then candidate genes assessed in additional cases (150 probands). Two families had the same rare variant in ANO1, which encodes a calcium-activated chloride channel, anoctamin-1. Haplotype analyses …

Temporal Characterization Of Acute Pain And Toxicity Kinetics During Radiation Therapy For Head And Neck Cancer A Retrospective Study, Vivian Salama, Sara Youssef, Tianlin Xu, Kareem A Wahid, Jaime Chen, Jillian Rigert, Anna Lee, Katherine A Hutcheson, Brandon Gunn, Jack Phan, Adam S Garden, Steven J Frank, William Morrison, Jay P Reddy, Michael T Spiotto, Mohamed A Naser, Cem Dede, Renjie He, Abdallah S R Mohamed, Lisanne V Van Dijk, Ruitao Lin, Carlos J Roldan, David I Rosenthal, Clifton D Fuller, Amy C Moreno, Md Anderson Head And Neck Cancer Symptom Working Group

Faculty, Staff and Student Publications

OBJECTIVES: Pain during Radiation Therapy (RT) for oral cavity/oropharyngeal cancer (OC/OPC) is a clinical challenge due to its multifactorial etiology and variable management. The objective of this study was to define complex pain profiles through temporal characterization of pain descriptors, physiologic state, and RT-induced toxicities for pain trajectories understanding.

MATERIALS AND METHODS: Using an electronic health record registry, 351 OC/OPC patients treated with RT from 2013 to 2021 were included. Weekly numeric scale pain scores, pain descriptors, vital signs, physician-reported toxicities, and analgesics were analyzed using linear mixed effect models and Spearman's correlation. Area under the pain curve (AUC

RESULTS: …

Stromal-Derived Nrg1 Enables Oncogenic Kras Bypass In Pancreas Cancer, Jincheng Han, Jiaqian Xu, Yonghong Liu, Shaoheng Liang, Kyle A Labella, Deepavali Chakravarti, Denise J Spring, Yan Xia, Ronald A Depinho

Faculty, Staff and Student Publications

Activating KRAS mutations (KRAS*) in pancreatic ductal adenocarcinoma (PDAC) drive anabolic metabolism and support tumor maintenance. KRAS* inhibitors show initial antitumor activity followed by recurrence due to cancer cell-intrinsic and immune-mediated paracrine mechanisms. Here, we explored the potential role of cancer-associated fibroblasts (CAFs) in enabling KRAS* bypass and identified CAF-derived NRG1 activation of cancer cell ERBB2 and ERBB3 receptor tyrosine kinases as a mechanism by which KRAS*-independent growth is supported. Genetic extinction or pharmacological inhibition of KRAS* resulted in up-regulation of ERBB2 and ERBB3 expression in human and murine models, which prompted cancer cell utilization of CAF-derived NRG1 as a …

Atopic Dermatitis And The Risk Of Myocardial Infarction And All-Cause Mortality: A Nationwide Population-Based Cohort Study, Yu Ri Woo, Minah Cho, Kyung Do Han, Sang Hyun Cho, Ji Hyun Lee

Faculty, Staff and Student Publications

PURPOSE: Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with various comorbidities. However, inconsistent results on the risk of myocardial infarction (MI) and mortality have been reported in patients with AD. This study was aimed to evaluate the risk of MI and all-cause mortality in patients with AD.

METHODS: This nationwide population-based retrospective cohort study enrolled 56,205 adults ≥ 20 years of age with AD and 3,825,609 controls without AD from the Korean National Health Service (NHIS) database from 2009 to 2016.

RESULTS: The risk of MI (adjusted hazard ratio [aHR], 1.111, 95% confidence interval [CI], 1.050-1.176) was …

Diversity, Equity, And Inclusion In The Melanoma Research Community, Marie E Portuallo, David Y Lu, Gretchen M Alicea, Joel Bolling, Rebecca Lee, Jennifer Mcquade, Allison Betof Warner, Michael Davies, Ashani Weeraratna, Jessie Villanueva, Vito W Rebecca

Faculty, Staff and Student Publications

The inaugural Diversity and Inclusion in Science Session was held during the 2021 Society for Melanoma Research (SMR) congress. The goal of the session was to discuss diversity, equity, and inclusion in the melanoma research community and strategies to promote the advancement of underrepresented melanoma researchers. An international survey was conducted to assess the diversity, equity, and inclusion (DEI) climate among researchers and clinicians within the Society for Melanoma Research (SMR). The findings suggest there are feelings and experiences of inequity, bias, and harassment within the melanoma community that correlate with one's gender, ethnic/racial group, and/or geographic location. Notably, significant …

Maximizing Wound Coverage In Full-Thickness Skin Defects: A Randomized-Controlled Trial Of Autologous Skin Cell Suspension And Widely Meshed Autograft Versus Standard Autografting, Sharon Henry, Steven Mapula, Mark Grevious, Kevin N. Foster, Herbert Phelan, Jeffrey Shupp, Rodney Chan, David Harrington, Neil Mashruwala, David A. Brown, Haaris Mir, George Singer, Alfredo Cordova, Lisa Rae, Theresa Chin, Lourdes Castanon, Derek Bell, William Hughes, Joseph A. Molnar

Department of Surgery Faculty Papers

BACKGROUND: Traumatic insults, infection, and surgical procedures can leave skin defects that are not amenable to primary closure. Split-thickness skin grafting (STSG) is frequently used to achieve closure of these wounds. Although effective, STSG can be associated with donor site morbidity, compounding the burden of illness in patients undergoing soft tissue reconstruction procedures. With an expansion ratio of 1:80, autologous skin cell suspension (ASCS) has been demonstrated to significantly decrease donor skin requirements compared with traditional STSG in burn injuries. We hypothesized that the clinical performance of ASCS would be similar for soft tissue reconstruction of nonburn wounds.

METHODS: A …

Chronic Illness Education 2023: Workout Your Mind: How Exercise Can Help Fight Depression, Sarah Bdeir, Kevin Cobty, Dana Josifoski, Joyce Li, Sujit Prasad, Ahmad Khatib, Kishwar Basith

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Survey For Copd Risk Factors For Clinic Use, Saleh Al-Juburi, Alexa Kalaj, Amrutha Kotlure, Hannah Lee, Salvatore Serra, Juwan Taylor, Mirna Kaafarani

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: How To Promote Mental Wellness As Medical Students, Sneha Bhargava, Basel Mhaimeed, Demetrius Moncrease, Parshva Salvi, Marissa Yaldo, Fadumo Yusuf, Anna Kang

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Misconceptions Surrounding Adult Obesity With Targeted Educational Materials, Andrew Lemmen, Shrila Rajendran, Daniel Saxon, Devun Birk, Timothy Li, Pooja Polamarasetti

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Analyzing Effective And In-Effective Treatment Options For Physicians In Training With Anxiety And Depression., Sophia Gandarillas, Cyra Kharas, Robert Leone, Mihika Sridhar, Kishwar Basith

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Prevalence Of Anxiety In First And Second-Generation American Medical Students, Cyrus Amirfazli, Nina Brahmbhatt, Adam Chaban, Aminah Fayyaz, Karina Haleblian, Ajay Pradhan, Kishwar Basith

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Managing Cholesterol, Gabriella Gonzales, Leane Kuo, Tannia M. Rodriguez, Anah Nicolai, Mitchell Wu, Michelle Malik

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Deciphering Food Labels, Paige Awtrey, Jessica Elderkin, Hajirah Farah, Dylan Kato, Michael Salloum, Jack Visser, George Kidess

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Prevention And Treatment Of Cardiovascular Disease Amid Food Insecurity In Southeast Michigan, Kirsten Brinkmeier, John Gallagher, Hovhannes Hayrapetyan, Nasser Junedi, Julia Malewicz, Alisha Williams

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Healthy Heart Habits For Kids, Chase Aaron, Jane Dow, Max Jones, Karamoja Monchamp, Ingrid Rocha, Arhan Shetty, Kelsey Gockman

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Increasing Youth Healthy Eating In The Pediatric Population: An Effort To Reduce Cardiovascular Risk Factors, Mohammad Al-Hadidi, Molly Dahle, Jovan Jande, Krishni Kumaresan, Jessica Long, Trevor Ruesch, Jamil Jomaa

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Adult Obesity & Sedentary Lifestyle In Detroit, Lisa Doan, Kimera Harris, Cornelius Lau, Hani Nasr, Ciara White, Pooja Polamarasetti

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Empowering Type I Diabetes Management In Adolescents (13-18 Yo), James Burtka, Nelson Pinto, Alyssa Rogers, Siddharth Tirumala, Maria Tjilos, Kaitlin Verkuilen, Aarti Patel

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: From Playtime To Prevention: Innovative Approaches For Promoting Cardiovascular Health In Children, Isabella Anton, Parnia Behinaein, Patrick Kollman, Yage Pi, Samy Shelbaya, Jacob Waitzman, Dhruvil Patel

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: A Guide To Chronic Obstructive Pulmonary Disease, Emma Burke, David Allen, Elena Busuito, Zachary Chen, Rebekah Pitpitan, Rubi Walker, Mirna Kaafarani

Patient Education Projects

No abstract provided.

Chronic Illness Education 2023: Increasing Nutritional Literacy For Adults Living With Type Ii Diabetes In Detroit, Mi, Morolayo Ilori, Katherine Gavagan, Izma Khaliq, Srikanth Pillai, Nabeel Sumbal, Derya Turk, Zechariah Jean

Patient Education Projects

No abstract provided.