Medicine and Health Sciences Commons^™

Enhanced Phenotypes For Identifying Opioid Overdose In Emergency Department Visit Electronic Health Record Data, Ralph Ward, Jihad S. Obeid, Lindsey Jennings, Elizabeth Szwast, William Garrett Hayes, Royal Pipaliya, Cameron Bailey, Skylar Faul, Brianna Polyak, George Hamilton Baker

School of Medicine Publications

Background

Accurate identification of opioid overdose (OOD) cases in electronic healthcare record (EHR) data is an important element in surveillance, empirical research, and clinical intervention. We sought to improve existing OOD electronic phenotypes by incorporating new data types beyond diagnostic codes and by applying several statistical and machine learning methods.

Materials and Methods

We developed an EHR dataset of emergency department visits involving OOD cases or patients considered at risk for an OOD and ascertained true OOD status through manual chart reviews. We developed and validated prediction models using Random Forest, Extreme Gradient Boost, and Elastic Net models that incorporated …

Intouch Week Of September 11, 2023, New York Medical College

InTouch

• Intranasal Immunization Offers Stronger Protection Against COVID-19
• Campus Playground Gets a Makeover
• SOM Student Publishes Research Conducted In Prestigious Fellowship Program
• NYMC and TU Hosts “Ninety Minutes: The Medical Magazine of the Web”
• Calling Artists For The Asprinio Fitness Center Wall Project
• NYMC Research: Patric K. Stanton, Ph.D.

Treatment Of Older Adults With Flt3-Mutated Aml: Emerging Paradigms And The Role Of Frontline Flt3 Inhibitors, Nicholas J Short, Daniel Nguyen, Farhad Ravandi

Faculty, Staff and Student Publications

FLT3 is the most frequently mutated gene in acute myeloid leukemia (AML), with FLT3 internal tandem duplication (ITD) mutations being associated with a more aggressive clinical course. While two large, randomized clinical trials have shown a survival benefit with the frontline use of an oral FLT3 inhibitor (midostaurin or quizartinib) in patients with FLT3-mutated AML, the role of FLT3 inhibitors in older adults with newly diagnosed FLT3-mutated AML remains unclear. A definitive improvement in survival has not been observed in intensively treated patients over 60 years of age receiving frontline FLT3 inhibitors. Furthermore, many patients with FLT3-mutated AML are unsuitable …

Determinants Of Hormonal Contraceptive Use Among Adolescent Females In The Republic Of Benin, Marlene Joannie Bewa

USF Tampa Graduate Theses and Dissertations

Introduction: Globally, 17 million adolescent girls—ages 15-19-- give birth every year, which affects educational and professional outcomes such as school completion, future employment, and economic empowerment. In Benin, adolescent girls have a substantial unmet need for sexual and reproductive health (SRH) information and services. More specifically, the need for hormonal contraceptive products and services, as well as accurate, age-appropriate, and comprehensive sexuality education, is not met universally.

Objective: This research objective is to understand personal, behavioral, and environmental barriers and facilitators to the access and uptake of modern contraceptive methods among adolescents in Benin. This will inform recommendations for improving …

Integrative Multi-Omic Cancer Profiling Reveals Dna Methylation Patterns Associated With Therapeutic Vulnerability And Cell-Of-Origin, Wen-Wei Liang, Rita Jui-Hsien Lu, Reyka G Jayasinghe, Steven M Foltz, Eduard Porta-Pardo, Yifat Geffen, Michael C Wendl, Rossana Lazcano, Iga Kolodziejczak, Yizhe Song, Akshay Govindan, Elizabeth G Demicco, Xiang Li, Yize Li, Sunantha Sethuraman, Samuel H Payne, David Fenyö, Henry Rodriguez, Maciej Wiznerowicz, Hui Shen, D R Mani, Karin D Rodland, Alexander J Lazar, Ana I Robles, Li Ding, Clinical Proteomic Tumor Analysis Consortium

Faculty, Staff and Student Publications

DNA methylation plays a critical role in establishing and maintaining cellular identity. However, it is frequently dysregulated during tumor development and is closely intertwined with other genetic alterations. Here, we leveraged multi-omic profiling of 687 tumors and matched non-involved adjacent tissues from the kidney, brain, pancreas, lung, head and neck, and endometrium to identify aberrant methylation associated with RNA and protein abundance changes and build a Pan-Cancer catalog. We uncovered lineage-specific epigenetic drivers including hypomethylated FGFR2 in endometrial cancer. We showed that hypermethylated STAT5A is associated with pervasive regulon downregulation and immune cell depletion, suggesting that epigenetic regulation of STAT5A …

Sex Hormone-Binding Globulin (Shbg) Mitigates Er Stress And Improves Viability And Insulin Sensitivity In Adipose-Derived Mesenchymal Stem Cells (Asc) Of Equine Metabolic Syndrome (Ems)-Affected Horses, Nabila Bourebaba, Mateusz Sikora, Badr Qasem, Lynda Bourebaba, Krzysztof Marycz

Faculty, Staff and Student Publications

BACKGROUND: Equine metabolic syndrome (EMS), which encompasses insulin resistance, low-grade inflammation and predisposition to laminitis is a critical endocrine disorder among the most prevalent conditions affecting horses from different breeds. According to the most recent research, low human sex hormone-binding globulin (SHBG) serum levels correlate with an increased risk of obesity, insulin resistance and diabetes, and may contribute to overall metabolic dysregulations. This study aimed to test whether exogenous SHBG could protect EMS affected adipose-derived stromal stem cells (EqASC

METHODS: EqASC

RESULTS: Obtained data demonstrated that exogenous SHBG treatment significantly promoted ASCs cells proliferation, cell cycle and survival with reduced …

Krasg12d Inhibition Reprograms The Tumor Microenvironment Of Early And Advanced Pancreatic Cancer To Promote Fas-Mediated Killing By Cd8+ T Cells, Krishnan K Mahadevan, Kathleen M Mcandrews, Valerie S Lebleu, Sujuan Yang, Hengyu Lyu, Bingrui Li, Amari M Sockwell, Michelle L Kirtley, Sami J Morse, Barbara A Moreno Diaz, Michael P Kim, Ningping Feng, Anastasia M Lopez, Paola A Guerrero, Francesca Paradiso, Hikaru Sugimoto, Kent A Arian, Haoqiang Ying, Yasaman Barekatain, Lakshmi Kavitha Sthanam, Patience J Kelly, Anirban Maitra, Timothy P Heffernan, Raghu Kalluri

Faculty, Staff and Student Publications

The KRASG12D mutation is present in nearly half of pancreatic adenocarcinomas (PDAC). We investigated the effects of inhibiting the KRASG12D mutant protein with MRTX1133, a non-covalent small molecule inhibitor of KRASG12D, on early and advanced PDAC and its influence on the tumor microenvironment. Employing 16 different models of KRASG12D-driven PDAC, we demonstrate that MRTX1133 reverses early PDAC growth, increases intratumoral CD8+ effector T cells, decreases myeloid infiltration, and reprograms cancer associated fibroblasts. MRTX1133 leads to regression of both established PanINs and advanced PDAC. Regression of advanced PDAC requires CD8+ T cells and immune checkpoint blockade (ICB) synergizes with MRTX1133 …

Elimination Of Oncogenic Kras In Genetic Mouse Models Eradicates Pancreatic Cancer By Inducing Fas-Dependent Apoptosis By Cd8+ T Cells, Krishnan K Mahadevan, Valerie S Lebleu, Elena V Ramirez, Yang Chen, Bingrui Li, Amari M Sockwell, Mihai Gagea, Hikaru Sugimoto, Lakshmi Kavitha Sthanam, Desiree Tampe, Michael Zeisberg, Haoqiang Ying, Abhinav K Jain, Ronald A Depinho, Anirban Maitra, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

Oncogenic KrasG12D (Kras*) is critical for the initiation and maintenance of pancreatic ductal adenocarcinoma (PDAC), and a known repressor of tumor immunity. Conditional elimination of Kras* in genetic mouse models of PDAC leads to reactivation of Fas, CD8+ T cell mediated apoptosis, and complete eradication of tumors. Kras* elimination recruits activated CD4+ and CD8+ T cells and promotes the activation of antigen presenting cells. Mechanistically, Kras* mediated immune evasion involves epigenetic regulation of the Fas death receptor in cancer cells, via methylation of its promoter region. Further, analysis of human RNA sequencing identifies that high KRAS expressing PDAC tumors show …

The Spatiotemporal Dynamics Of Semantic Integration In The Human Brain, Evan S Schaffer, Neeli Mishra, Matthew R Whiteway, Wenze Li, Michelle B Vancura, Jason Freedman, Kripa B Patel, Venkatakaushik Voleti, Liam Paninski, Elizabeth M C Hillman, L F Abbott, Richard Axel

Faculty, Staff and Student Publications

What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous behaviors. This revealed neural representations of behavior on multiple spatial and temporal scales. The activity of most neurons correlated (or anticorrelated) with running and flailing over timescales that ranged from seconds to a minute. Grooming elicited a weaker global response. Significant residual activity not directly correlated with behavior was high dimensional and reflected the activity …

Reduced Maternal Immunity And Vertical Transfer Of Immunity Against Sars-Cov-2 Variants Of Concern With Covid-19 Exposure Or Initial Vaccination In Pregnancy., Rupsa Boelig, Sidhartha Chaudhury, Gregory D Gromowski, Sandra Mayer, Jocelyn King, Zubair H Aghai, Elke Bergmann-Leitner

Department of Obstetrics and Gynecology Faculty Papers

INTRODUCTION: As the SARS-CoV-2 pandemic continues to evolve, we face new variants of concern with a concurrent decline in vaccine booster uptake. We aimed to evaluate the difference in immunity gained from the original SARS-CoV-2 mRNA vaccine series in pregnancy versus SARS-CoV-2 exposure during pregnancy against recent variants of concern.

STUDY DESIGN: This is a retrospective analysis of previously collected samples from 192 patients who delivered between February 2021 and August 2021. Participants were categorized as 1) COVID vaccine: mRNA vaccine in pregnancy, 2) COVID-exposed, and 3) controls. The primary outcome was neutralizing capacity against wild-type, Delta, and Omicron-B1 between …

Peripheral Arterial Disease And Complications Of Total Knee Arthroplasty: Indications For Advanced Vascular Imaging And Minimally Invasive Soft Tissue Coverage Procedures, Kristopher Katira, Antony Martin, Anna Garbuzov, James Ferrer, Brian Chuong, Ross Parkerson, George Chimento

School of Medicine Faculty Publications

Soft tissue coverage of knee wounds can be challenging, in particular in the setting of peripheral arterial disease and knee arthroplasty complications. Options for soft-tissue coverage range from conservative wound care to invasive pedicled and free flaps. Unlike traditional wound coverage problems in plastic surgery patients, arthroplasty coverage decisions oblige surgeons to take into account the possibility of secondary orthopedic procedures. The two cases presented in this manuscript demonstrate the importance of vascular imaging, in particular angiography. In both cases, the workhorse medial gastrocnemius flap harvest could have resulted in critical limb ischemia. When secondary orthopedic revision is required at …

Phasedancer: A Novel Targeted Assembler Of Segmental Duplications Unravels The Complexity Of The Human Chromosome 2 Fusion Going From 48 To 46 Chromosomes In Hominin Evolution, Barbara Poszewiecka, Krzysztof Gogolewski, Justyna A Karolak, Paweł Stankiewicz, Anna Gambin

Faculty, Staff and Students Publications

Resolving complex genomic regions rich in segmental duplications (SDs) is challenging due to the high error rate of long-read sequencing. Here, we describe a targeted approach with a novel genome assembler PhaseDancer that extends SD-rich regions of interest iteratively. We validate its robustness and efficiency using a golden-standard set of human BAC clones and in silico-generated SDs with predefined evolutionary scenarios. PhaseDancer enables extension of the incomplete complex SD-rich subtelomeric regions of Great Ape chromosomes orthologous to the human chromosome 2 (HSA2) fusion site, informing a model of HSA2 formation and unravelling the evolution of human and Great Ape genomes.

A Split And Inducible Adenine Base Editor For Precise In Vivo Base Editing, Hongzhi Zeng, Qichen Yuan, Fei Peng, Dacheng Ma, Ananya Lingineni, Kelly Chee, Peretz Gilberd, Emmanuel C Osikpa, Zheng Sun, Xue Gao

Faculty, Staff and Students Publications

DNA base editors use deaminases fused to a programmable DNA-binding protein for targeted nucleotide conversion. However, the most widely used TadA deaminases lack post-translational control in living cells. Here, we present a split adenine base editor (sABE) that utilizes chemically induced dimerization (CID) to control the catalytic activity of the deoxyadenosine deaminase TadA-8e. sABE shows high on-target editing activity comparable to the original ABE with TadA-8e (ABE8e) upon rapamycin induction while maintaining low background activity without induction. Importantly, sABE exhibits a narrower activity window on DNA and higher precision than ABE8e, with an improved single-to-double ratio of adenine editing and …

Proteogenomic Insights Suggest Druggable Pathways In Endometrial Carcinoma, Yongchao Dou, Lizabeth Katsnelson, Marina A Gritsenko, Yingwei Hu, Boris Reva, Runyu Hong, Yi-Ting Wang, Iga Kolodziejczak, Rita Jui-Hsien Lu, Chia-Feng Tsai, Wen Bu, Wenke Liu, Xiaofang Guo, Eunkyung An, Rebecca C Arend, Jasmin Bavarva, Lijun Chen, Rosalie K Chu, Andrzej Czekański, Teresa Davoli, Elizabeth G Demicco, Deborah Delair, Kelly Devereaux, Saravana M Dhanasekaran, Peter Dottino, Bailee Dover, Thomas L Fillmore, Mckenzie Foxall, Catherine E Hermann, Tara Hiltke, Galen Hostetter, Marcin Jędryka, Scott D Jewell, Isabelle Johnson, Andrea G Kahn, Amy T Ku, Chandan Kumar-Sinha, Paweł Kurzawa, Alexander J Lazar, Rossana Lazcano, Jonathan T Lei, Yi Li, Yuxing Liao, Tung-Shing M Lih, Tai-Tu Lin, John A Martignetti, Ramya P Masand, Rafał Matkowski, Wilson Mckerrow, Mehdi Mesri, Matthew E Monroe, Jamie Moon, Ronald J Moore, Michael D Nestor, Chelsea Newton, Tatiana Omelchenko, Gilbert S Omenn, Samuel H Payne, Vladislav A Petyuk, Ana I Robles, Henry Rodriguez, Kelly V Ruggles, Dmitry Rykunov, Sara R Savage, Athena A Schepmoes, Tujin Shi, Zhiao Shi, Jimin Tan, Mason Taylor, Mathangi Thiagarajan, Joshua M Wang, Karl K Weitz, Bo Wen, C M Williams, Yige Wu, Matthew A Wyczalkowski, Xinpei Yi, Xu Zhang, Rui Zhao, David Mutch, Arul M Chinnaiyan, Richard D Smith, Alexey I Nesvizhskii, Pei Wang, Maciej Wiznerowicz, Li Ding, D R Mani, Hui Zhang, Matthew L Anderson, Karin D Rodland, Bing Zhang, Tao Liu, David Fenyö

Faculty, Staff and Students Publications

We characterized a prospective endometrial carcinoma (EC) cohort containing 138 tumors and 20 enriched normal tissues using 10 different omics platforms. Targeted quantitation of two peptides can predict antigen processing and presentation machinery activity, and may inform patient selection for immunotherapy. Association analysis between MYC activity and metformin treatment in both patients and cell lines suggests a potential role for metformin treatment in non-diabetic patients with elevated MYC activity. PIK3R1 in-frame indels are associated with elevated AKT phosphorylation and increased sensitivity to AKT inhibitors. CTNNB1 hotspot mutations are concentrated near phosphorylation sites mediating pS45-induced degradation of β-catenin, which may render …

Adapting Shift Work Schedules For Sleep Quality, Sleep Duration, And Sleepiness In Shift Workers., Gerben Hulsegge, Pieter Coenen, Gregg M Gascon, Manisha Pahwa, Birgit Greiner, Ciarán Bohane, Imelda S Wong, Juha Liira, Rachel Riera, Daniela V Pachito

Ambulatory and Primary Care Articles

BACKGROUND: Shift work is associated with insufficient sleep, which can compromise worker alertness with ultimate effects on occupational health and safety. Adapting shift work schedules may reduce adverse occupational outcomes.

OBJECTIVES: To assess the effects of shift schedule adaptation on sleep quality, sleep duration, and sleepiness among shift workers.

SEARCH METHODS: We searched CENTRAL, PubMed, Embase, and eight other databases on 13 December 2020, and again on 20 April 2022, applying no language restrictions.

SELECTION CRITERIA: We included randomised controlled trials (RCTs) and non-RCTs, including controlled before-after (CBA) trials, interrupted time series, and cross-over trials. Eligible trials evaluated any of …

Sex Differences In Paternal Arsenic-Induced Intergenerational Metabolic Effects Are Mediated By Estrogen, Yanfeng Xue, Yingyun Gong, Xin Li, Fei Peng, Guolian Ding, Zhao Zhang, Junchao Shi, Ilma Saleh Savul, Yong Xu, Qi Chen, Leng Han, Shengyong Mao, Zheng Sun

Faculty, Staff and Students Publications

BACKGROUND: Gene-environment interactions contribute to metabolic disorders such as diabetes and dyslipidemia. In addition to affecting metabolic homeostasis directly, drugs and environmental chemicals can cause persistent alterations in metabolic portfolios across generations in a sex-specific manner. Here, we use inorganic arsenic (iAs) as a prototype drug and chemical to dissect such sex differences.

METHODS: After weaning, C57BL/6 WT male mice were treated with 250 ppb iAs in drinking water (iAsF0) or normal water (conF0) for 6 weeks and then bred with 15-week-old, non-exposed females for 3 days in cages with only normal water (without iAs), to generate iAsF1 or conF1 …

Effects On Slp Graduate Students’ Clinical Skills Following “Case Study Nights”, George Pagano, Carmine Lacertosa, Fred Stal

Discovery Day

This poster describes the evolution of graduate students in their clinical knowledge and attitudes before and after participating in case study nights. Speech- Language Pathology students from Long Island University (LIU) -Brooklyn had the opportunity to observe a professional describe various clinical etiologies, assessments, and treatments coupled with a client presentation during two semesters. Student evaluations measured clinician’s outcome with respect to service delivery and treatment approaches when working with multiple clients with communication disorders.

Are We Ready For This?: Students’ Introspection On Clinical Preparedness, George Pagano, Lauren Sher, Caroline Woods

Discovery Day

This poster describes graduate student clinicians' self-assessment of preparedness for off-campus pediatric and adult externships in speech-language pathology by examining the reported positive components as well as perceived areas of development in their graduate-level preparation. The subsequent feedback has implications for enhancing the clinical preparation aspect of speech-language pathology graduate programs.

How To Stop Killing Patients With Healthcare-Associated Infections, Ann Bernstein, Emily Demino, Jonathan Eng, Peter Forman

Discovery Day

Background. Healthcare-associated infections (HAIs), also known as nosocomial infections, are a significant cause of preventable death for patients receiving treatment for medical or surgical conditions. HAIs are attributed to 99,000 patient deaths in the United States annually. These infections rack up an estimated $20 billion of additional costs per year by extending the length of stay for hospitalized patients and increasing the cost of treatment at the same time. Current empirical findings highlight the severity and gravity of the effect that HAIs have on patient communities around the world.

Methodology. The Google Scholar search engine was utilized with the search …

Tick-Talk: Human Babesiosis, Brieanne Bieber, Angelica Giuliani, Hannah Palochak

Discovery Day

Background: Human babesiosis is a parasitic infection caused by species of the protozoan Babesia, most commonly B. microti. The organism invades the erythrocytes causing them to lyse. The infection is transmitted through the Ixodes tick, which is commonly found on white mice and white tailed deer. Outbreaks of this disease most commonly occur in the Northeastern region of the United States, specifically New England and Long Island, New York, during spring and summer months, due to the greater proximity of vectors to humans. Patients who are infected can have a range of symptoms from asymptomatic to severe manifestations, including …

Prescription Drug Abuse, Matthew Barlow, Chloe Connolly, Tim Godfrey, Jenna Plean

Discovery Day

Background. In the United States, the leading cause of injury death is from prescription drug overdose. The most commonly abused prescription medications are (a) pain relievers (opioids), (b) CNS depressants (tranquilizers, sedatives, hypnotics), and (c) stimulants. Opioids are a class of drugs that includes both heroin and prescription pain relievers. CNS depressants are for managing anxiety and stimulates are used in ADHD. A consequence of abuse is drug overdose death, with opioids being the leading cause. Opioids are safe for short term use but have a strong potential to be abused resulting in addiction. In order to understand this …

All Shook Up: A Review Of Sport-Related Concussions In High School Athletes, Daniel Mclaren, Kevin O’Connell, Matthew Paparella, Nicholas Petito

Discovery Day

Background: Concussions comprise 24.8% of the total injuries in high school athletes, putting developing brains at risk for neurocognitive dysfunction. Recent research has been geared towards finding the most effective process for (a) diagnosing, (b) treating and (c) preventing concussions. The most recent data from the Centers for Disease Control and Prevention (CDC) show that 329,290 children were diagnosed with a sports related concussion or traumatic brain injury (TBI) in 2012.

Methods: A systematic review of current literature was performed using the Long Island University online library database and Google Scholar. Search terms included: (a) concussion, (b) sports, (c) high …

Teen Pregnancy, Carly Anderson, Brianna Fuessler, Anna Forgach, Holly Stumpf

Discovery Day

Background. In 2015, more than 200,000 babies were born to women aged 15-19, a record low for teens in the United States. However, it remains substantially higher than in other western industrialized nations. The highest rates of teen pregnancy occur in the rural areas of the Southern states. Black and Hispanic teens are more than twice as likely as White teens to become pregnant. Factors that contribute to teen pregnancy include (a) low socioeconomic conditions, (b) lower education, (c) low income levels, (d) decreased healthcare access, and (e) being on welfare. The U.S. government has been working to combat these …

Domestic Violence, Kevin Berardi, Ashley John, Ryan Moran, Steph Perella

Discovery Day

Background. Domestic violence, intimate partner violence (IPV), or domestic abuse, is defined as a pattern of behaviors used by one partner to maintain power and control over another partner in an intimate relationship. These behaviors include physical acts and nonphysical acts, including using (a) intimidation, (b) coercion, (c) threats, (d) isolation, and (e) finances to maintain power. Domestic abuse occurs regardless of (a) race, (b) gender, (c) age, (d) sexual orientation, and (e) socioeconomic status. The immediate effects of domestic violence manifest in the form of physical injuries, including (a) cuts, (b) bruises, (c) bitemarks, (d) concussions, and (e) …

Have You Checked Your Skin Late?, Kristina Mortzfield, Jordan Clark, Lia Disciascio, Mary Lynam

Discovery Day

Background. Skin cancer, while preventable, is diagnosed in 20% of Americans. All populations are susceptible, but factors that increase risk of development include: (a) male gender, (b) fair skin, (c) aging, (d) personal history of UV radiation exposure, and (e) previous history of skin cancer. Non-melanoma types, basal cell carcinoma and squamous cell carcinoma, have a lower risk of metastasis while melanoma, if not detected early, can result in distant and fatal metastasis.

Methods. A review of the literature was completed using Google. The terms searched included: (a) skin cancer risk factors, (b) skin cancer prevention, (c) skin cancer screening. …

Social Inequalities And The Adoption Of Health Misinformation In Cameroon: Implications On Health Behaviour, Eugene Nche Che

Library Philosophy and Practice (e-journal)

Public health restrictions in response to the COVID-19 pandemic resulted in an increase in the reliance on social media for peer interactions. This resulted in the proliferation of medical misinformation and conspiracy theories that undermined public support for disease control measures, and influenced negative health attitudes such as vaccine denial. The aim of this study was to determine how social inequalities influence the adoption of health related misinformation, and the extent to which the adoption of health misinformation results in poor health behaviours. The study employed an exploratory survey design, and relied on both quantitative and qualitative methods to collect …

Pica: The Mysterious Eating Disorder, James Ferrante, Justin Fisher, Tara Sung, Spencer Wenzel

Discovery Day

Background. ‘Pica’ is the Latin word for magpie, a bird that ingests inedible substances. The DSM-V defines pica as a disorder of persistent eating of nonnutritive, nonfood substances over a period of at least one month. Although pica is a disorder that affects a widespread population, it is seen as a social anomaly which prevents patients from admitting their behavior. As the behavior continues unnoticed and untreated, patients will experience the adverse effects of ingesting foreign materials. Thus, healthcare providers and family members should educate themselves on pica’s etiologies and manifestations to prevent complications and avoid unnecessary hospitalizations.

Methods. …

Postpartum Depression, Danny Masterson, Christina Butigian, Arlinda Kubati, Emily Ramdeholl, Leticia Sanchez

Discovery Day

Background: Postpartum depression (PPD) affects 10-20% of women in the US. It is a condition in which mothers’ experience depression during pregnancy or within 4 weeks postpartum. Numerous physiological, socio-economic, and psychological factors have been linked to postpartum depression. Mothers with postpartum depression can experience feelings of (a) extreme sadness, (b) anxiety, and (c) exhaustion that may make it difficult for them to complete activities of daily living for themselves or for others. PPD in its severest form can lead to suicide and acts of harming the newborn.

Methodology: Information was gathered using the search engines: (a) Pubmed, (b) PubMed …

Cracking The Code: The Systematic Development Of A Matrix To Increase Credible And Dependable Coding Of Qualitative Data, Greta Gray, Ms, Otr/L

Post-Professional Occupational Therapy Doctorate Culminating Presentations

A systematic, credible, and dependable coding matrix was developed to deductively code the qualitative data from the Clinician’s Perceptions of Infusing Coaching into their Occupational Therapy Practice study (CPIC). A coding matrix is used to organize qualitative data into meaningful units of text to be interpreted by the researchers. Codes for this project were deductively organized under categories from Roger’s Diffusion of Innovation Theory (RDIT), a framework that identifies how a new idea is adopted in practice. Five preliminary coders, with one leading the process, participated in the development of the coding matrix to reduce the risk of bias influencing …

Life Balance, Stress, And Occupational Burnout In Occupational Therapy Assistant Students: An Exploratory Study, Olivia W. Hammond, Mba, Otr/L, Cht

Post-Professional Occupational Therapy Doctorate Culminating Presentations

The United States healthcare worker burnout crisis demands immediate attention. College is critical for preparing occupational therapy assistant students (OTA) to address life balance, stress, and burnout as they transition into the workforce. However, little is known about these factors in this population. In this doctoral presentation, the primary author presents her doctoral project, which explored OTA students' life balance and its association with their perceived stress and occupational burnout across employment status, residential status, years of study, and age. A cross-sectional Qualtrics e-survey was distributed to OTA students ages 18 and older, including a demographic survey, Life Balance Inventory …