Medicine and Health Sciences Commons^™

A Case Report Of Subdiaphragmatic Right Kidney As A Positional Variant Of Cephalad Renal Ectopia, Chandana A Reddy, Suganitha Balasundaram, Vasudha Kulkarni

KCACON 2023

No abstract provided.

Bilateral Accessory Bellies Of The Anterior Belly Of The Digastric Muscle: Anatomical Variations And Clinical Implications, Harshavardhan Sai Sadineni, Sushma Prabhath, Nandini P Bhat

KCACON 2023

No abstract provided.

Heart Connections - Endocardial Cushion Defects, Akshatha Jois Y A, Nishaa P, Hema N

KCACON 2023

No abstract provided.

Variations In The Size Of The Right Kidney And Branching Pattern Of Right And Left Renal Artery And Its Hilar Structures With Its Clinical Correlations - A Case Report, Febina Fk, R Huban Thomas

KCACON 2023

No abstract provided.

A Study Of Morphometric And Morphological Variations Of Lister’S Tubercle, Ameen Hussain, Shivpriya ., Seema .

KCACON 2023

No abstract provided.

Absent Pulmonary Valve Syndrome, Dhanush M, Padmalatha K, Nishaa P

KCACON 2023

No abstract provided.

Aberrant Head Of Triceps And Biceps Brachii Muscle With Vascular Variation: A Case Report., Aamna Kausar, Roshni Sadashiv, Sharanya Rao, Sonal Nayak, Veena V Kulkarni

KCACON 2023

No abstract provided.

Arteriovenous Fistula Between The Inferior Mesenteric Artery And Vein, Agamdeep Singh Bedi, Sheetal V Pattanshetti, Shilpa M Bhimalli

KCACON 2023

No abstract provided.

Morphology And Morphometry Of Human External Ear – A Comparative Study, Shwetha ., Chandni Gupta

KCACON 2023

No abstract provided.

A Review Of Federal And Statewide Guidelines And Their Effects On Orthopedics, Johann Braithwaite, John M. Tarazi, Joshua Gruber, Jarret Boroniec, Randy Cohn, Adam Bitterman

HPD Articles

In the past three decades, the use of opioids has risen tremendously. Pain was named the “fifth patient vital sign” in the 1990s, and from that point, opioid usage has continued to grow throughout the 2010s leading to its recognition as a crisis. The United States is responsible for 80% of the global opioid usage while only accounting for less than 5% of the global population. Previously opioids were mostly used to treat acute pain, however, opioids have been most recently used to manage chronic pain as well. The opioid crisis has presented new challenges in treating pain while preventing …

Association Between Number Of Vasopressors And Mortality In Covid-19 Patients, Michael Sunnaa, Mina Kerolos, Max Ruge, Ahmad Gill, Jeanne M. Du-Fay-De-Lavallaz, Perry Robin, Joanne Michelle Dumlao Gomez, Kim Williams, Anupama Rao, Annabelle Santos Volgman, Karolina Marinescu, Tisha Marie Suboc

COVID-19 Papers, Posters, and Presentations

Study objective

Study the clinical outcomes associated with the number of concomitant vasopressors used in critically ill COVID-19 patients.

Design

A single-center retrospective cohort study was conducted on patients admitted with COVID-19 to the intensive care unit (ICU) between March and October 2020.

Setting

Rush University Medical Center, United States.

Participants

Adult patients at least 18 years old with COVID-19 with continuous infusion of any vasopressors were included.

Main outcome measures

60-day mortality in COVID-19 patients by the number of concurrent vasopressors received.

Results

A total of 637 patients met our inclusion criteria, of whom 338 (53.1 %) required the …

A Review Of The Role Of Tendon Stem Cells In Tendon-Bone Regeneration, Junjie Chen, Chuanfeng Jiang, Lu Yin, Yingqi Liu, Yue He, Sen Li, Huarui Shen

Faculty, Staff and Student Publications

Tendon-bone injuries are a prevalent health concern associated with sports and other physically demanding activities. These injuries have a limited innate healing ability, often leading to the formation of scar tissue rather than the regeneration of healthy tendon tissue. This scar tissue results from excessive fibrosis during the early healing process and often leads to reduced tendon function and an increased risk of reinjury. Traditionally, surgical reconstruction has been the primary treatment for tendon-bone injuries. However, restoring the natural structure and mechanical properties of tendons after surgical reconstruction presents a considerable challenge. Recently, the potential of stem cell therapy has …

Her3 Functions As An Effective Therapeutic Target In Triple Negative Breast Cancer To Potentiate The Antitumor Activity Of Gefitinib And Paclitaxel, Hui Lyu, Fei Shen, Sanbao Ruan, Congcong Tan, Jundong Zhou, Ann D. Thor, Bolin Liu

School of Medicine Faculty Publications

Background: Triple negative breast cancer (TNBC) represents a significant clinical challenge. Chemotherapy remains the mainstay for a large part of TNBC patients, whereas drug resistance and tumor recurrence frequently occur. It is in urgent need to identify novel molecular targets for TNBC and develop effective therapy against the aggressive disease. Methods: Immunohistochemistry was performed to examine the expression of HER3 in TNBC samples. Western blots were used to assess protein expression and activation. Cell proliferation and viability were determined by cell growth (MTS) assays. TCGA databases were analyzed to correlate HER3 mRNA expression with the clinical outcomes of TNBC patients. …

Classification Of Missense Variants In The N-Methyl-D-Aspartate Receptor Grin Gene Family As Gain- Or Loss-Of-Function, Scott J Myers, Hongjie Yuan, Riley E Perszyk, Jing Zhang, Sukhan Kim, Kelsey A Nocilla, James P Allen, Jennifer M Bain, Johannes R Lemke, Dennis Lal, Timothy A Benke, Stephen F Traynelis

Faculty, Staff and Student Publications

Advances in sequencing technology have generated a large amount of genetic data from patients with neurological conditions. These data have provided diagnosis of many rare diseases, including a number of pathogenic de novo missense variants in GRIN genes encoding N-methyl-d-aspartate receptors (NMDARs). To understand the ramifications for neurons and brain circuits affected by rare patient variants, functional analysis of the variant receptor is necessary in model systems. For NMDARs, this functional analysis needs to assess multiple properties in order to understand how variants could impact receptor function in neurons. One can then use these data to determine whether the …

Characterization Of An Mtbp Hypomorphic Allele In A Diethylnitrosamine-Induced Liver Carcinogenesis Model, Atul Ranjan, Elizabeth A. Thoenen, Atsushi Kaida, Stephanie Wood, Terry Van Dyke, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

MTBP is implicated in cell cycle progression, DNA replication, and cancer metastasis. However, the function of MTBP remains enigmatic and is dependent on cellular contexts and its cellular localization. To understand the in vivo physiological role of MTBP, it is important to generate Mtbp knockout mice. However, complete deletion of the Mtbp gene in mice results in early embryonic lethality, while its heterozygous deletion shows modest biological phenotypes, including enhanced cancer metastasis. To overcome this and better characterize the in vivo physiological function of MTBP, we, for the first time, generated mice that carry an Mtbp hypomorphic allele (MtbpH …

First-In-Human Prospective Trial Of Sonobiopsy In High-Grade Glioma Patients Using Neuronavigation-Guided Focused Ultrasound, Jinyun Yuan, Lu Xu, Chih-Yen Chien, Yaoheng Yang, Yimei Yue, Siaka Fadera, Andrew H Stark, Katherine E Schwetye, Arash Nazeri, Rupen Desai, Umeshkumar Athiraman, Aadel A Chaudhuri, Hong Chen, Eric C Leuthardt

2020-Current year OA Pubs

Sonobiopsy is an emerging technology that combines focused ultrasound (FUS) with microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive molecular diagnosis of brain diseases. Here, we report the first-in-human prospective trial of sonobiopsy in high-grade glioma patients to evaluate its feasibility and safety in enriching plasma circulating tumor biomarkers. A nimble FUS device integrated with a clinical neuronavigation system was used to perform sonobiopsy following an established clinical workflow for neuronavigation. Analysis of blood samples collected before and after FUS sonication showed that sonobiopsy enriched plasma circulating tumor DNA (ctDNA), including a maximum increase of 1.6-fold for the mononucleosome …

Machine Learning Techniques For The Identification Of Risk Factors Associated With Food Insecurity Among Adults In Arab Countries During The Covid-19 Pandemic, Radwan Qasrawi, Maha Hoteit, Reema Tayyem, Khlood Bookari, Haleama Al Sabbah, Iman Kamel, Somaia Dashti, Sabika Allehdan, Hiba Bawadi, Mostafa Waly, Mohammed O. Ibrahim, Stephanny Vicuna Polo, Diala Abu Al-Halawa

All Works

BACKGROUND: A direct consequence of global warming, and strongly correlated with poor physical and mental health, food insecurity is a rising global concern associated with low dietary intake. The Coronavirus pandemic has further aggravated food insecurity among vulnerable communities, and thus has sparked the global conversation of equal food access, food distribution, and improvement of food support programs. This research was designed to identify the key features associated with food insecurity during the COVID-19 pandemic using Machine learning techniques. Seven machine learning algorithms were used in the model, which used a dataset of 32 features. The model was designed to …

Morphometry Of Accessory Head Of Flexor Pollicis Longus – A Cadaveric Study, Shwetha K, Pushpalatha K

KCACON 2023

No abstract provided.

Exploring The Pathological Implications Of Tuberous Sclerosis On Anatomy: A Case Study, Deepali Malik, Padmalatha K, Nishaa P

KCACON 2023

No abstract provided.

Menstrual Cup Cognizance: Unveiling The Perceptions And Barriers Among Medical Students, Harshitha Md, Archana Bj, Asha K R

KCACON 2023

No abstract provided.

Transverse Process Of Atlas As A Surgical Landmark For Various Head And Neck Surgeries – A Ct Assisted Study, Madhu P Raj, Jyothi K C, Shailaja Shetty, Ashok Kumar

KCACON 2023

No abstract provided.

A Cross-Sectional Study To Correlate Cognitive Ability And Learning Styles Using Wechsler Adult Intelligence Scale And Vark Questionnaire Tools, Krishna Sree Yalamanchili, Vasudha Kulkarni

KCACON 2023

No abstract provided.

Foetal Cardiac Anatomical Evaluation As A Biomarker For Chromosomal Anomalies: A Case Series, Eshaan U Jalihal, Padmalatha K, Nishaa P

KCACON 2023

No abstract provided.

Psychology And Attitude Regarding Voluntary Body Donation In Registered Body Donors And Nonbody Donors: A Comparative Study, Shambhavi Vivek Joshi, Elvin Joshua Pinto, Anne D Souza, Pratham Kogalur, Prasanna L C

KCACON 2023

No abstract provided.

A Study On Symmetry Of Important Paired Foramina In Human Skulls, Aditya Krishna Murthy

KCACON 2023

No abstract provided.

Morphometric Study On Lateralsulcus (Ls): A Cadaveric Study, Sarthak Pandey, Rohini Punja

KCACON 2023

No abstract provided.

Lipid Composition Of Developing Central Nervous System, Sumukha Hegde, Divya Chandran, Dinesh Upadhya

KCACON 2023

No abstract provided.

Collagen And Elastic Fiber Frequency In Tortuous Arteries By Microscopy, Thanush P, Ashwini C Appaji

KCACON 2023

No abstract provided.

Effect Of Metformin On Behavioral Changes And Inflammatory Markers In Brain In Bacterial Lipopolysaccharide Induced Neuroinflammatory Model Of Albino Wistar Rats, Vandana Blossom, Sheethal Ullal, Rajalaxmi Rai, Nayantara Ak, Aradhana Marathe

KCACON 2023

No abstract provided.

A Morphological Study Of Interthalamic Adhesions In Northern Karnataka Brains: A Cadaveric Study, Navya Sharma, Suma Dnyanesh, Anushka Dungarwal, Shilpa Mbhimalli

KCACON 2023

No abstract provided.