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Articles 69271 - 69300 of 325298

Full-Text Articles in Medicine and Health Sciences

Takotsubo Syndrome: Is It Just A “Broken Heart”?, Haris Muhammad Md, Angila Bag Md, Aparna Iyer Md Nov 2023

Takotsubo Syndrome: Is It Just A “Broken Heart”?, Haris Muhammad Md, Angila Bag Md, Aparna Iyer Md

Journal of Community Hospital Internal Medicine Perspectives

Takotsubo Cardiomyopathy (TCM) is known as stress induced cardiomyopathy which may be triggered by emotional or physical stress. It contributes approximately 0.02% of all the hospitalizations in the US. It is acute and reversible cardiomyopathy with transient decrease in ventricular function and unremarkable angiogram. TCM was initially considered to be a benign condition however recent studies have shown that it may be associated with complications and mortality similar to acute coronary syndrome (ACS). Therefore, its early recognition is fundamental in the management of potentially reversible pathology.


Tachycardia Therapy Outcomes Of Ischemic Versus Nonischemic Cardiomyopathy On Cardiac Resynchronization Therapy: A Propensity Score-Matched Analysis, Jahanzeb Malik, Muhammad Awais, Muhammad Shabbir, Amer Rauf, Shehzad Zaffar, Azmat Hayat, Amin Mehmoodi Nov 2023

Tachycardia Therapy Outcomes Of Ischemic Versus Nonischemic Cardiomyopathy On Cardiac Resynchronization Therapy: A Propensity Score-Matched Analysis, Jahanzeb Malik, Muhammad Awais, Muhammad Shabbir, Amer Rauf, Shehzad Zaffar, Azmat Hayat, Amin Mehmoodi

Journal of Community Hospital Internal Medicine Perspectives

Objective This investigation aimed to investigate differences between dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) patients treated with cardiac resynchronization therapy with defibrillator (CRT-D) for tachycardia therapy-related outcomes as well as mortality during follow-up of at least 1 year. Methods Seventy-eight patients with DCM (n=42) and ICM (n=36) with implantation or upgradation to CRT-D were included in this study and analyzed for incidence of non-sustained ventricular tachycardia (NSVT), non-sustained ventricular fibrillation (NSVF), defibrillator therapies, anti-tachycardia pacing (ATP), and mortality. Results DCM was the underlying etiology in 42 (53.84%) and ICM in 36 (46.15%). Time to first therapy was numerically longer …


Severe Thrombocytopenia In Infective Endocarditis, Mayuri Patel, Biplov Adhikari, Amrit Devkota, Mahsa Mohebtash Nov 2023

Severe Thrombocytopenia In Infective Endocarditis, Mayuri Patel, Biplov Adhikari, Amrit Devkota, Mahsa Mohebtash

Journal of Community Hospital Internal Medicine Perspectives

Thrombocytopenia can be seen in about 20-25% of patients with bacterial infective endocarditis (IE). Platelets have a major role in the pathogenesis of endocarditis, and they are also sensitive monitors of systemic host response to bacteremia. Thrombocytopenia on presentation of patients with IE identifies higher risk groups and carries higher mortality risk. The presence of thrombocytopenia is an independent prognosticator of poor outcomes in IE. We present a case of a 40-year-old male with the history of injection drug use who was diagnosed with IE and was found to have severe thrombocytopenia on admission was treated with intravenous antibiotics, which …


Adult Ileoileal Intussusception Caused By Diffuse Large B-Cell Lymphoma, Scarlet Louis-Jean, Shire Chaudhry, Stephanie Richards Nov 2023

Adult Ileoileal Intussusception Caused By Diffuse Large B-Cell Lymphoma, Scarlet Louis-Jean, Shire Chaudhry, Stephanie Richards

Journal of Community Hospital Internal Medicine Perspectives

Adult intussusception is a rare diagnosis that can be caused by non-Hodgkin’s diffuse large B-cell lymphoma (DLBCL). In this case report, we discuss a middle-aged man who presented with non-specific symptoms of intussusception and absence of classic B symptoms. He was found to have intussusception secondary to stage IIIE, CD20 positive DLBCL. The patient underwent small bowel resection with anastomosis, followed by 6 cycles of R-CHOP, which resulted in complete remission of his neoplasm. In reporting this case, we hope to further highlight the role of malignancy in intussusception and guidance on appropriate therapy.


Utilization And Short-Term Outcomes Of Percutaneous Left Atrial Appendage Occlusion In Patients With Cancer, Yaqi Zhang, Zhuoran Yang, Muhammad Usman Almani, Raquel Soon-Shiong, Bolun Liu Nov 2023

Utilization And Short-Term Outcomes Of Percutaneous Left Atrial Appendage Occlusion In Patients With Cancer, Yaqi Zhang, Zhuoran Yang, Muhammad Usman Almani, Raquel Soon-Shiong, Bolun Liu

Einstein Health Papers

Background

Percutaneous left atrial appendage occlusion (LAAO) has been rapidly evolving since FDA’s approval in 2015 and has become more of a same-day-discharge procedure. Cancer patient with atrial fibrillation/flutter (AF) population can benefit from the procedure but the in-hospital outcomes and readmission data were rarely studied.

Objectives

We investigated the utilization, in-hospital and readmission outcomes in cancer patients with AF who underwent LAAO.

Methods

Data were derived from the National Inpatient Sample and National Readmissions Database from 2016 to 2019. Patients with primary diagnosis of AF admitted for LAAO (ICD-10 code 02L73DK) were grouped by cancer as a secondary diagnosis. …


Immune Responses Induced At One Hour Post Cataract Surgery Wounding Of The Chick Lens, Jodirae Dedreu, Morgan Basta, Janice Walker, Sue Menko Nov 2023

Immune Responses Induced At One Hour Post Cataract Surgery Wounding Of The Chick Lens, Jodirae Dedreu, Morgan Basta, Janice Walker, Sue Menko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

While the lens is an avascular tissue with an immune-privileged status, studies have now revealed that there are immune responses specifically linked to the lens. The response to lens injury, such as following cataract surgery, has been shown to involve the activation of the resident immune cell population of the lens and the induction of immunomodulatory factors by the wounded epithelium. However, there has been limited investigation into the immediate response of the lens to wounding, particularly those induced factors that are intrinsic to the lens and its associated resident immune cells. Using an established chick embryo ex vivo cataract …


Clinical Factors Associated With Need For Neurosurgical Care In Young Children With Imaging For Macrocephaly: A Case Control Study, Jessica F. Rohde, Jeffrey Campbell, Julie Barbera, Elena Taylor, Ashok Ramachandra, Christopher Gegg, Andrea Scherer, Joseph Piatt Nov 2023

Clinical Factors Associated With Need For Neurosurgical Care In Young Children With Imaging For Macrocephaly: A Case Control Study, Jessica F. Rohde, Jeffrey Campbell, Julie Barbera, Elena Taylor, Ashok Ramachandra, Christopher Gegg, Andrea Scherer, Joseph Piatt

Department of Pediatrics Faculty Papers

BACKGROUND: Macrocephaly is present in 2.3% of children with important neurosurgical conditions in the differential diagnosis. The objective of this study was to identify clinical associations with actionable imaging findings among children with head imaging for macrocephaly.

METHODS: We conducted a case-control study of head imaging studies ordered for macrocephaly among children 24 months and younger in a multistate children's health system. Four neurosurgeons reviewed the images, determining cases to be a 'concern' if neurosurgical follow-up or intervention was indicated. Electronic health records were reviewed to collect patient-level data and to determine if surgery was performed. Controls were matched 3:1 …


Preoperative 18f-Fdg Pet/Ct And Ct Radiomics For Identifying Aggressive Histopathological Subtypes In Early Stage Lung Adenocarcinoma, Wookjin Choi, Chia-Ju Liu, Sadegh Riyahi Alam, Jung Hun Oh, Raj Vaghjiani, John Humm, Wolfgang Weber, Prasad Adusumilli, Joseph Deasy, Wei Lu Nov 2023

Preoperative 18f-Fdg Pet/Ct And Ct Radiomics For Identifying Aggressive Histopathological Subtypes In Early Stage Lung Adenocarcinoma, Wookjin Choi, Chia-Ju Liu, Sadegh Riyahi Alam, Jung Hun Oh, Raj Vaghjiani, John Humm, Wolfgang Weber, Prasad Adusumilli, Joseph Deasy, Wei Lu

Department of Radiation Oncology Faculty Papers

Lung adenocarcinoma (ADC) is the most common non-small cell lung cancer. Surgical resection is the primary treatment for early-stage lung ADC while lung-sparing surgery is an alternative for non-aggressive cases. Identifying histopathologic subtypes before surgery helps determine the optimal surgical approach. Predominantly solid or micropapillary (MIP) subtypes are aggressive and associated with a higher likelihood of recurrence and metastasis and lower survival rates. This study aims to non-invasively identify these aggressive subtypes using preoperative 18F-FDG PET/CT and diagnostic CT radiomics analysis. We retrospectively studied 119 patients with stage I lung ADC and tumors ≤ 2 cm, where 23 had …


Plasma Metabolomics And Quantitative Interstitial Abnormalities In Ever-Smokers, Bina Choi, Raúl San José Estépar, Suneeta Godbole, Jeffrey L Curtis, Jennifer M Wang, Rubén San José Estépar, Ivan O Rosas, Jared R Mayers, Brian D Hobbs, Craig P Hersh, Samuel Y Ash, Meilan K Han, Russell P Bowler, Kathleen A Stringer, George R Washko, Wassim W Labaki Nov 2023

Plasma Metabolomics And Quantitative Interstitial Abnormalities In Ever-Smokers, Bina Choi, Raúl San José Estépar, Suneeta Godbole, Jeffrey L Curtis, Jennifer M Wang, Rubén San José Estépar, Ivan O Rosas, Jared R Mayers, Brian D Hobbs, Craig P Hersh, Samuel Y Ash, Meilan K Han, Russell P Bowler, Kathleen A Stringer, George R Washko, Wassim W Labaki

Faculty, Staff and Students Publications

BACKGROUND: Quantitative interstitial abnormalities (QIA) are an automated computed tomography (CT) finding of early parenchymal lung disease, associated with worse lung function, reduced exercise capacity, increased respiratory symptoms, and death. The metabolomic perturbations associated with QIA are not well known. We sought to identify plasma metabolites associated with QIA in smokers. We also sought to identify shared and differentiating metabolomics features between QIA and emphysema, another smoking-related advanced radiographic abnormality.

METHODS: In 928 former and current smokers in the Genetic Epidemiology of COPD cohort, we measured QIA and emphysema using an automated local density histogram method and generated metabolite profiles …


Hepatic Palmitoyl-Proteomes And Acyl-Protein Thioesterase Protein Proximity Networks Link Lipid Modification And Mitochondria, Sarah L Speck, Dhaval P Bhatt, Qiang Zhang, Sangeeta Adak, Li Yin, Guifang Dong, Chu Feng, Wei Zhang, M Ben Major, Xiaochao Wei, Clay F Semenkovich Nov 2023

Hepatic Palmitoyl-Proteomes And Acyl-Protein Thioesterase Protein Proximity Networks Link Lipid Modification And Mitochondria, Sarah L Speck, Dhaval P Bhatt, Qiang Zhang, Sangeeta Adak, Li Yin, Guifang Dong, Chu Feng, Wei Zhang, M Ben Major, Xiaochao Wei, Clay F Semenkovich

2020-Current year OA Pubs

Acyl-protein thioesterases 1 and 2 (APT1 and APT2) reverse S-acylation, a potential regulator of systemic glucose metabolism in mammals. Palmitoylation proteomics in liver-specific knockout mice shows that APT1 predominates over APT2, primarily depalmitoylating mitochondrial proteins, including proteins linked to glutamine metabolism. miniTurbo-facilitated determination of the protein-protein proximity network of APT1 and APT2 in HepG2 cells reveals APT proximity networks encompassing mitochondrial proteins including the major translocases Tomm20 and Timm44. APT1 also interacts with Slc1a5 (ASCT2), the only glutamine transporter known to localize to mitochondria. High-fat-diet-fed male mice with dual (but not single) hepatic deletion of APT1 and APT2 have insulin …


Quantifying And Correcting Bias Due To Outcome Dependent Self-Reported Weights In Longitudinal Study Of Weight Loss Interventions, Jiayi Tong, Rui Duan, Ruowang Li, Chongliang Luo, Jason H Moore, Jingsan Zhu, Gary D Foster, Kevin G Volpp, William S Yancy Jr, Pamela A Shaw, Yong Chen Nov 2023

Quantifying And Correcting Bias Due To Outcome Dependent Self-Reported Weights In Longitudinal Study Of Weight Loss Interventions, Jiayi Tong, Rui Duan, Ruowang Li, Chongliang Luo, Jason H Moore, Jingsan Zhu, Gary D Foster, Kevin G Volpp, William S Yancy Jr, Pamela A Shaw, Yong Chen

2020-Current year OA Pubs

In response to the escalating global obesity crisis and its associated health and financial burdens, this paper presents a novel methodology for analyzing longitudinal weight loss data and assessing the effectiveness of financial incentives. Drawing from the Keep It Off trial-a three-arm randomized controlled study with 189 participants-we examined the potential impact of financial incentives on weight loss maintenance. Given that some participants choose not to weigh themselves because of small weight change or weight gains, which is a common phenomenon in many weight-loss studies, traditional methods, for example, the Generalized Estimating Equations (GEE) method tends to overestimate the effect …


Comparison Of Joint Mobilization And Movement Pattern Training For Patients With Hip-Related Groin Pain: A Pilot Randomized Clinical Trial, Marcie Harris-Hayes, Patricia Zorn, Karen Steger-May, Megan M Burgess, Rebecca D Demargel, Suzanne Kuebler, John Clohisy, Simon Haroutounian Nov 2023

Comparison Of Joint Mobilization And Movement Pattern Training For Patients With Hip-Related Groin Pain: A Pilot Randomized Clinical Trial, Marcie Harris-Hayes, Patricia Zorn, Karen Steger-May, Megan M Burgess, Rebecca D Demargel, Suzanne Kuebler, John Clohisy, Simon Haroutounian

2020-Current year OA Pubs

OBJECTIVE: The objective of this study was to assess the feasibility of completing a randomized clinical trial (RCT) and examine the preliminary effects of 2 interventions for hip-related groin pain (HRGP).

METHODS: In this pilot RCT, patients with HRGP, who were 18 to 40 years old, were randomized (1:1 ratio) to a joint mobilization (JtMob) group or a movement pattern training (MoveTrain) group. Both treatments included 10 supervised sessions and a home exercise program. The goal of JtMob was to reduce pain and improve mobility through peripherally and centrally mediated pain mechanisms. The key element was physical therapist-provided JtMob. The …


Potential Effects Of Masking, Quarantine, Treatment, And Vaccines On Swine Flu, Helen Pennington, Erin Bodine Nov 2023

Potential Effects Of Masking, Quarantine, Treatment, And Vaccines On Swine Flu, Helen Pennington, Erin Bodine

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Mathematical Modeling, Analysis And Simulation Of Patient Detox Journey, Adan Baca, Diego Gonzalez Nov 2023

Mathematical Modeling, Analysis And Simulation Of Patient Detox Journey, Adan Baca, Diego Gonzalez

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.


Smartphone-Based High-Performance Thin Layer Chromatographic Method Along With Benchtop Densitometry For Simultaneous Quantification Of Co-Formulated Dutasteride With Silodosin And Their Residuals On Manufacturing Equipment's Surfaces, Mina Wadie, Ezzat M. Abdel-Moety, Mamdouh R. Rezk, Hoda M. Marzouk Nov 2023

Smartphone-Based High-Performance Thin Layer Chromatographic Method Along With Benchtop Densitometry For Simultaneous Quantification Of Co-Formulated Dutasteride With Silodosin And Their Residuals On Manufacturing Equipment's Surfaces, Mina Wadie, Ezzat M. Abdel-Moety, Mamdouh R. Rezk, Hoda M. Marzouk

Bulletin of Faculty of Pharmacy Cairo University

The significant advancement in smartphone digital cameras has expanded the possibilities for their usage as a portable, easily used detector in several analytical procedures. In this study, a unique and smart high-performance thin layer chromatographic (HPTLC) method based on a smartphone was presented for the simultaneous analysis of silodosin and dutasteride, two urological medications used to treat benign prostatic hyperplasia.First, environmentally friendly mobile phase was used to achieve chromatographic separation, and for repeatable findings, the produced plates were shot using the back camera of smartphone mounted atop a made-up twoillumination source chamber.


Comparative Analysis Of Swine Antibody Responses Following Vaccination With Live-Attenuated And Killed African Swine Fever Virus Vaccines, Hung Q. Luong, Huong T. L. Lai, Lam Q. Truong, The N. Nguyen, Hanh D. Vu, Hoa T. Nguyen, Lan T. Nguyen, Trang H. Pham, David Scott Mcvey, Hiep Vu Nov 2023

Comparative Analysis Of Swine Antibody Responses Following Vaccination With Live-Attenuated And Killed African Swine Fever Virus Vaccines, Hung Q. Luong, Huong T. L. Lai, Lam Q. Truong, The N. Nguyen, Hanh D. Vu, Hoa T. Nguyen, Lan T. Nguyen, Trang H. Pham, David Scott Mcvey, Hiep Vu

Nebraska Center for Virology: Faculty Publications

African swine fever virus (ASFV) is circulating in many swine-producing countries, causing significant economic losses. It is observed that pigs experimentally vaccinated with a live-attenuated virus (LAV) but not a killed virus (KV) vaccine develop solid homologous protective immunity. The objective of this study was to comparatively analyze antibody profiles between pigs vaccinated with an LAV vaccine and those vaccinated with a KV vaccine to identify potential markers of vaccineinduced protection. Thirty ASFV seronegative pigs were divided into three groups: Group 1 received a single dose of an experimental LAV, Group 2 received two doses of an experimental KV vaccine, …


Reduced Grey Matter Volume In Adolescents With Conduct Disorder: A Region‑Of‑Interest Analysis Using Multivariate Generalized Linear Modeling, Ru Zhang, Robert James R. Blair, Karina S. Blair, Matthew Dobbertin, Jaimie Elowsky, Johannah Bashford‑Largo, Ahria J. Dominguez, Melissa Hatch, Sahil Bajaj Nov 2023

Reduced Grey Matter Volume In Adolescents With Conduct Disorder: A Region‑Of‑Interest Analysis Using Multivariate Generalized Linear Modeling, Ru Zhang, Robert James R. Blair, Karina S. Blair, Matthew Dobbertin, Jaimie Elowsky, Johannah Bashford‑Largo, Ahria J. Dominguez, Melissa Hatch, Sahil Bajaj

Center for Brain, Biology, and Behavior: Faculty Publications

Background

Conduct disorder (CD) involves a group of behavioral and emotional problems that usually begins during childhood or adolescence. Structural brain alterations have been observed in CD, including the amygdala, insula, ventrolateral and medial prefrontal cortex, anterior cingulate cortex, and fusiform gyrus. The current study developed a multivariate generalized linear model (GLM) to differentiate adolescents with CD from typically developing (TD) adolescents in terms of grey matter volume (GMV).

Methods

The whole‐brain structural MRI data were collected from 96 adolescents with CD (mean age = 16.188 ± 1.259 years; mean IQ = 104.292 ± 8.107 ; 63 males) and 90 …


Perioperative Experiences Of Transgender Adults Seeking Gender-Affirming Surgery, Alan T. Makhoul, R. Thomas Day, Jasmine C. Walker, Catherine Hammack-Aviran, Salam Al Kassis, Julian S. Winocour, Brian C. Drolet Nov 2023

Perioperative Experiences Of Transgender Adults Seeking Gender-Affirming Surgery, Alan T. Makhoul, R. Thomas Day, Jasmine C. Walker, Catherine Hammack-Aviran, Salam Al Kassis, Julian S. Winocour, Brian C. Drolet

Law Faculty Scholarship

Purpose: Transgender individuals have been systemically excluded from U.S. health care, creating barriers and disparities that other populations do not face. Gender-affirming surgery represents an emerging treatment modality for gender dysphoria, however, little is known about how transgender patients experience the perioperative pathway. This study sought to characterize the experiences of transgender patients seeking genderaffirming surgery and identify opportunities for improvement.

Methods: A qualitative study was conducted at an academic medical center between July and December 2020. Semistructured interviews were conducted after a postoperative encounter with adult patients who had undergone gender-affirming surgery within the past year. A purposive sampling …


Evaluation Of The Success Rate Of Endoscopic Dacryocystorhinostomy With Early Bicanalicular Stent Removal, Lauren N. Demaria, Evan H. Black, Dianne M. Schlachter Nov 2023

Evaluation Of The Success Rate Of Endoscopic Dacryocystorhinostomy With Early Bicanalicular Stent Removal, Lauren N. Demaria, Evan H. Black, Dianne M. Schlachter

Conference Presentation Abstracts

No abstract provided.


Integrative Review: Job Satisfaction Among Nurse Leaders, Meghan Wheeler, Sharrissa Beckford, Chelsey Smith Nov 2023

Integrative Review: Job Satisfaction Among Nurse Leaders, Meghan Wheeler, Sharrissa Beckford, Chelsey Smith

Master of Science in Nursing Final Projects

The intention behind this research was to identify trends and factors that impact the job satisfaction of nurse leaders in the healthcare setting in America today. The organizational support provided to nursing leaders was consistently found to be a key part of job satisfaction. Mental health and well-being were also identified as integral pieces to ensure nurse leaders were confident in their role and decrease intent to leave. Work/life balance was also found to be an important factor in ensuring nurse leaders experienced high levels of job satisfaction. The burnout of nurse leaders can happen for a variety of reasons …


Identification Of Blood Protein Biomarkers Associated With Prostate Cancer Risk Using Genetic Prediction Models: Analysis Of Over 140,000 Subjects, Hua Zhong, Jingjing Zhu, Shuai Liu, Dalia H Ghoneim, Praveen Surendran, Tao Liu, Sarah Fahle, Adam Butterworth, Md Ashad Alam, Hong-Wen Deng, Herbert Yu, Chong Wu, Lang Wu Nov 2023

Identification Of Blood Protein Biomarkers Associated With Prostate Cancer Risk Using Genetic Prediction Models: Analysis Of Over 140,000 Subjects, Hua Zhong, Jingjing Zhu, Shuai Liu, Dalia H Ghoneim, Praveen Surendran, Tao Liu, Sarah Fahle, Adam Butterworth, Md Ashad Alam, Hong-Wen Deng, Herbert Yu, Chong Wu, Lang Wu

Faculty, Staff and Student Publications

Prostate cancer (PCa) brings huge public health burden in men. A growing number of conventional observational studies report associations of multiple circulating proteins with PCa risk. However, the existing findings may be subject to incoherent biases of conventional epidemiologic studies. To better characterize their associations, herein, we evaluated associations of genetically predicted concentrations of plasma proteins with PCa risk. We developed comprehensive genetic prediction models for protein levels in plasma. After testing 1308 proteins in 79 194 cases and 61 112 controls of European ancestry included in the consortia of BPC3, CAPS, CRUK, PEGASUS, and PRACTICAL, 24 proteins showed significant …


Repurposing Egfr Inhibitors For Oral Cancer Pain And Opioid Tolerance, Maria Daniela Santi, Morgan Zhang, Naijiang Liu, Chi T Viet, Tongxin Xie, Dane D Jensen, Moran Amit, Huilin Pan, Yi Ye Nov 2023

Repurposing Egfr Inhibitors For Oral Cancer Pain And Opioid Tolerance, Maria Daniela Santi, Morgan Zhang, Naijiang Liu, Chi T Viet, Tongxin Xie, Dane D Jensen, Moran Amit, Huilin Pan, Yi Ye

Faculty, Staff and Student Publications

Oral cancer pain remains a significant public health concern. Despite the development of improved treatments, pain continues to be a debilitating clinical feature of the disease, leading to reduced oral mobility and diminished quality of life. Opioids are the gold standard treatment for moderate-to-severe oral cancer pain; however, chronic opioid administration leads to hyperalgesia, tolerance, and dependence. The aim of this review is to present accumulating evidence that epidermal growth factor receptor (EGFR) signaling, often dysregulated in cancer, is also an emerging signaling pathway critically involved in pain and opioid tolerance. We presented preclinical and clinical data to demonstrate how …


Identification Of Circulating Proteins Associated With General Cognitive Function Among Middle-Aged And Older Adults, Adrienne Tin, Alison E Fohner, Qiong Yang, Jennifer A Brody, Gail Davies, Jie Yao, Dan Liu, Ilana Caro, Joni V Lindbohm, Michael R Duggan, Osorio Meirelles, Sarah E Harris, Valborg Gudmundsdottir, Adele M Taylor, Albert Henry, Alexa S Beiser, Ali Shojaie, Annabell Coors, Annette L Fitzpatrick, Claudia Langenberg, Claudia L Satizabal, Colleen M Sitlani, Eleanor Wheeler, Elliot M Tucker-Drob, Jan Bressler, Josef Coresh, Joshua C Bis, Julián Candia, Lori L Jennings, Maik Pietzner, Mark Lathrop, Oscar L Lopez, Paul Redmond, Robert E Gerszten, Stephen S Rich, Susan R Heckbert, Thomas R Austin, Timothy M Hughes, Toshiko Tanaka, Valur Emilsson, Ramachandran S Vasan, Xiuqing Guo, Yineng Zhu, Christophe Tzourio, Jerome I Rotter, Keenan A Walker, Luigi Ferrucci, Mika Kivimäki, Monique M B Breteler, Simon R Cox, Stephanie Debette, Thomas H Mosley, Vilmundur G Gudnason, Lenore J Launer, Bruce M Psaty, Sudha Seshadri, Myriam Fornage Nov 2023

Identification Of Circulating Proteins Associated With General Cognitive Function Among Middle-Aged And Older Adults, Adrienne Tin, Alison E Fohner, Qiong Yang, Jennifer A Brody, Gail Davies, Jie Yao, Dan Liu, Ilana Caro, Joni V Lindbohm, Michael R Duggan, Osorio Meirelles, Sarah E Harris, Valborg Gudmundsdottir, Adele M Taylor, Albert Henry, Alexa S Beiser, Ali Shojaie, Annabell Coors, Annette L Fitzpatrick, Claudia Langenberg, Claudia L Satizabal, Colleen M Sitlani, Eleanor Wheeler, Elliot M Tucker-Drob, Jan Bressler, Josef Coresh, Joshua C Bis, Julián Candia, Lori L Jennings, Maik Pietzner, Mark Lathrop, Oscar L Lopez, Paul Redmond, Robert E Gerszten, Stephen S Rich, Susan R Heckbert, Thomas R Austin, Timothy M Hughes, Toshiko Tanaka, Valur Emilsson, Ramachandran S Vasan, Xiuqing Guo, Yineng Zhu, Christophe Tzourio, Jerome I Rotter, Keenan A Walker, Luigi Ferrucci, Mika Kivimäki, Monique M B Breteler, Simon R Cox, Stephanie Debette, Thomas H Mosley, Vilmundur G Gudnason, Lenore J Launer, Bruce M Psaty, Sudha Seshadri, Myriam Fornage

Faculty, Staff and Student Publications

Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We identify 246 protein measures quantified by the SomaScan assay as associated with cognitive function (p < 4.9E-5, n up to 7289). Of these, 45 were replicated using SomaScan data, and three were replicated using Olink data at Bonferroni-corrected significance. Enrichment analysis linked the proteins associated with general cognitive function to cell signaling pathways and synapse architecture. Mendelian randomization analysis implicated higher levels of NECTIN2, a protein mediating viral entry into neuronal cells, with higher Alzheimer's disease (AD) risk (p = 2.5E-26). Levels of 14 other protein measures were implicated as consequences of AD susceptibility (p < 2.0E-4). Proteins implicated as causes or consequences of AD susceptibility may provide new insight into the potential relationship between immunity and AD susceptibility as well as potential therapeutic targets.


A Multicenter Study Validates The Who 2022 Classification For Conjunctival Melanocytic Intraepithelial Lesions With Clinical And Prognostic Relevance, Hardeep Singh Mudhar, Yamini Krishna, Simon Cross, Claudia Auw-Haedrich, Raymond Barnhill, Svetlana Cherepanoff, Ralph Eagle, James Farmer, Robert Folberg, Hans Grossniklaus, Martina C. Herwig-Carl, Martin Hyrcza, Sandra Lassalle, Karin U. Loeffler, Alexandre Moulin, Tatyana Milman, Robert M. Verdijk, Steffen Heegaard, Sarah E. Coupland Nov 2023

A Multicenter Study Validates The Who 2022 Classification For Conjunctival Melanocytic Intraepithelial Lesions With Clinical And Prognostic Relevance, Hardeep Singh Mudhar, Yamini Krishna, Simon Cross, Claudia Auw-Haedrich, Raymond Barnhill, Svetlana Cherepanoff, Ralph Eagle, James Farmer, Robert Folberg, Hans Grossniklaus, Martina C. Herwig-Carl, Martin Hyrcza, Sandra Lassalle, Karin U. Loeffler, Alexandre Moulin, Tatyana Milman, Robert M. Verdijk, Steffen Heegaard, Sarah E. Coupland

Wills Eye Hospital Papers

Several nomenclature and grading systems have been proposed for conjunctival melanocytic intraepithelial lesions (C-MIL). The fourth "WHO Classification of Eye Tumors" (WHO-EYE04) proposed a C-MIL classification, capturing the progression of noninvasive neoplastic melanocytes from low- to high-grade lesions, onto melanoma in situ (MIS), and then to invasive melanoma. This proposal was revised to the WHO-EYE05 C-MIL system, which simplified the high-grade C-MIL, whereby MIS was subsumed into high-grade C-MIL. Our aim was to validate the WHO-EYE05 C-MIL system using digitized images of C-MIL, stained with hematoxylin and eosin and immunohistochemistry. However, C-MIL cases were retrieved from 3 supraregional ocular pathology …


Glutamate Receptor Dysregulation And Platelet Glutamate Dynamics In Alzheimer's And Parkinson's Diseases: Insights Into Current Medications, Deepa Gautam, Ulhas Naik, Meghna Naik, Santosh Yadav, Rameshwar Nath Chaurasia, Debabrata Dash Nov 2023

Glutamate Receptor Dysregulation And Platelet Glutamate Dynamics In Alzheimer's And Parkinson's Diseases: Insights Into Current Medications, Deepa Gautam, Ulhas Naik, Meghna Naik, Santosh Yadav, Rameshwar Nath Chaurasia, Debabrata Dash

Cardeza Foundation for Hematologic Research

Two of the most prevalent neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and Parkinson's disease (PD), present significant challenges to healthcare systems worldwide. While the etiologies of AD and PD differ, both diseases share commonalities in synaptic dysfunction, thereby focusing attention on the role of neurotransmitters. The possible functions that platelets may play in neurodegenerative illnesses including PD and AD are becoming more acknowledged. In AD, platelets have been investigated for their ability to generate amyloid-ß (Aß) peptides, contributing to the formation of neurotoxic plaques. Moreover, platelets are considered biomarkers for early AD diagnosis. In PD, platelets have been studied for …


A Qualitative Study On Parenting Practices To Sustain Adolescent Health Behaviors In American Indian Families, Christine Hodgson, Dylan Decker, Teresia M O'Connor, Melanie Hingle, Francine C Gachupin Nov 2023

A Qualitative Study On Parenting Practices To Sustain Adolescent Health Behaviors In American Indian Families, Christine Hodgson, Dylan Decker, Teresia M O'Connor, Melanie Hingle, Francine C Gachupin

Children’s Nutrition Research Center Staff Publications

American Indian (AI) adolescents who practice healthy behaviors of sleep, nutrition, physical activity, and limited screen time can lower their lifetime risk of diet-sensitive disease. Little is known about how AI parenting practices influence the health behaviors of youth. The objective of this qualitative study was to explore how a group of AI parents of youths at risk of disease influenced their youth’s health behaviors after a family intervention. A secondary objective was to understand the role of AI parents in supporting and sustaining health behavior change in their youths following the intervention. Semi-structured in-depth interviews were conducted with AI …


How To Cru: Submitting A Clinical Research Utilization Form, Susan Stell, Gwendolyn Williams Nov 2023

How To Cru: Submitting A Clinical Research Utilization Form, Susan Stell, Gwendolyn Williams

Nursing Research and EBP Day 2023

To increase nurses’ comfort level with applying research to nursing practice, the Clinical Research Utilization (CRU) Form was created. Most nurses in the Rochester Regional Health system are required to complete one CRU Form every year, and nurses who complete 2 are able to use their second CRU for the clinical ladder. This poster helps provides guidance for nurses who are submitting a CRU Form.


Standardization Tools In Rrh Triage: A Nursing Based Review, Makayla Boff, Julie Voelkl, Cynthia Garofono, Colin Dewyea, Heather Farren Nov 2023

Standardization Tools In Rrh Triage: A Nursing Based Review, Makayla Boff, Julie Voelkl, Cynthia Garofono, Colin Dewyea, Heather Farren

Nursing Research and EBP Day 2023

Long wait times to be seen in outpatient clinics has led to an increase of triage messages for nurses within RRH. Could standardizing nursing triage protocol improve efficiency of patients care while building confidence and satisfaction among nurses? If protocols and standardizations tools are implemented to nursing staff then collectively we should see triage messages being answered in a more timely fashion, providing quicker care to patients as nurses will become more confident in the care they provide due to more precise guidelines being set out for them to follow.

Within RRH ambulatory offices surveys were created and distributed among …


Retention Among New Graduate Rns With And Without Transition To Practice Nurse Residency Programs, Grace Newman, Calie Ferraina, Amanda Burling Nov 2023

Retention Among New Graduate Rns With And Without Transition To Practice Nurse Residency Programs, Grace Newman, Calie Ferraina, Amanda Burling

Nursing Research and EBP Day 2023

Question: Does a structured nurse residency program affect the rate of retention among newly graduated RNs?

Hypothesis: A structured nurse residency program will impact the retention of new graduate RNs.

Methods: Articles reviewed for RN retention rates for nurses with and without nurse residency programs.

Results: Research supports that transition to practice (TTP) programs have been successful in new graduate RN retention rates. TTP programs help the new graduate develop skills to cope more effectively with their transition and lead to healthier, more balanced careers. Typical TTP programs were generally 12 months in length, had a dedicated program coordinator and …


Nurse Residency Program: Is This Worth My Time?, Gracie Puls, Sydney Wellspeak, Ashley Ernle, Cheryl Mcgee, Sarah Glor Nov 2023

Nurse Residency Program: Is This Worth My Time?, Gracie Puls, Sydney Wellspeak, Ashley Ernle, Cheryl Mcgee, Sarah Glor

Nursing Research and EBP Day 2023

Question: The purpose of this evidence-based practice project was to determine in new graduate nurses, how does Nurse Residency Program versus traditional orientation effect confidence and competence in high risk/low volume procedures.

Hypothesis: It was hypothesized that Nurse Residency Program was superior to traditional orientation for improving confidence and competence in high risk/low volume procedures.

Methods: A literature review was conducted using CINAHL with key words “orientation”, “Nurse Residency Program”, “confidence”, “competence”, and “transition”.

Results: The results of the literature search identified two studies that utilized quantitative strategies and found statistically significant results favoring Nurse Residency Programs over orientation alone. …