Medicine and Health Sciences Commons^™

Biochemical Recurrence Surrogacy For Clinical Outcomes After Radiotherapy For Adenocarcinoma Of The Prostate, Soumyajit Roy, Jeff M Michalski, Et Al.

2020-Current year OA Pubs

PURPOSE: The surrogacy of biochemical recurrence (BCR) for overall survival (OS) in localized prostate cancer remains controversial. Herein, we evaluate the surrogacy of BCR using different surrogacy analytic methods.

MATERIALS AND METHODS: Individual patient data from 11 trials evaluating radiotherapy dose escalation, androgen deprivation therapy (ADT) use, and ADT prolongation were obtained. Surrogate candidacy was assessed using the Prentice criteria (including landmark analyses) and the two-stage meta-analytic approach (estimating Kendall's tau and the

RESULTS: Overall, 10,741 patients were included. Dose escalation, addition of short-term ADT, and prolongation of ADT duration significantly improved BCR (hazard ratio [HR], 0.71 [95% CI, 0.63 …

Barriers And Enablers Of Weight Loss Maintenance After Bariatric Surgery, Shukri Farah Mohamed

Thesis/ Dissertation Defenses

Weight loss maintenance following bariatric surgery is still a challenging task, with a great probability of failure and weight regain. Aims: This qualitative study aimed to use the socialecological model to better understand barriers and facilitators of weight loss maintenance in adult Emiratis who have undergone bariatric surgery. Methods: This qualitative research involved in-depth individual interviews of 35 adults who performed bariatric surgery at Altaie Center in Abu Dhabi, United Arab Emirates between January 2018, and December 2019 (40 % male) with a mean age of 36.3±8.6 years. The only two surgeries included in this study were sleeve gastrectomy (SG) …

Quad Bike Injuries In The United Arab Emirates: Evidence For Injury Prevention Strategies, Preetha Menon Karuveetil

Thesis/ Dissertation Defenses

Background: Quad bikes, also known as all-terrain vehicles (ATVs), are versatile vehicles designed for navigating uneven terrain. Originally intended for agricultural purposes, they have gained popularity for recreational use, particularly in the Middle East, notably the United Arab Emirates (UAE). They are associated with substantial safety risks, resulting in injuries ranging from lacerations to severe traumatic injuries, imposing a significant economic burden on healthcare systems. Aims: This research addresses a critical gap in the existing literature by focusing on quad bike injuries in the unique context of the UAE, taking into account its desert environment, rider characteristics, and sociodemographic factors. …

Canagliflozin Ameliorates Autistic-Like Features And Mitigates Brain Oxidative Stress Levels In Valproic Acid-Induced Autism, Mohammad Moutaz Nakhal

Thesis/ Dissertation Defenses

Autism spectrum disorder (ASD) is a neurodevelopmental disease with a substantially increasing incidence rate. It is mainly characterized by repetitive behavior, intellectual difficulties, social communication and interactions deficits. Many medications, dietary supplements, and behavioral treatments have been recommended for ASD management, however, there is no cure yet. Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory and antioxidant effects. The main objective of this study is to assess the ability of canagliflozin in improving the behavioural characteristics of autistic rats and investigate the efficacy of canagliflozin in …

Large Language Model Use Cases For Instruction, Plus A Primer On Prompt Engineering, Roy Haggerty, Justin Cochran

LSU Health New Orleans Symposium Series on Artificial Intelligence

AMA Credit Designation Statement: The Louisiana State University School of Medicine, New Orleans designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

NCPD Credit Designation Statement: Nursing participants may earn 1.0 NCPD contact hours. Each nursing participant must be present for the entire session for which NCPD contact hours are requested and must complete an evaluation of the session to receive credit.

Effects Of Adropin On Metabolic Parameters, Oxidative Stress, And Cell Proliferation In Animal Model Of Diabetes Mellitus, Ifrah Ali

Thesis/ Dissertation Defenses

Diabetes mellitus (DM) is a major health issue that has reached alarming levels, affecting around 537 million of the global adult population. DM is a group of metabolic diseases characterized by hyperglycemia with disturbance in carbohydrate, fat, and protein metabolism. The proposed therapeutic options for DM are different according to their mechanism of action, and peptide therapy is one of these options. Adropin, a peptide hormone involved in energy homeostasis, has shown promising results in the treatment of diabetes by lowering fasting blood glucose, reducing insulin resistance, and minimizing fat storage. Moreover, it has been demonstrated that adropin is engaged …

Early Life Exposure To Broccoli Sprouts Confers Stronger Protection Against Enterocolitis Development In An Immunological Mouse Model Of Inflammatory Bowel Disease, Lola Holcomb, Johanna M. Holman, Molly Hurd, Brigitte Lavoie, Louisa Colucci, Benjamin Hunt, Timothy Hunt, Marissa Kinney, Jahnavi Pathak, Gary M. Mawe, Peter L. Moses, Emma Perry, Allesandra Stratigakis, Tao Zhang, Grace Chen, Suzanne L. Ishaq, Yanyan Li

Pharmacy Faculty Scholarship

Crohn’s disease (CD) is a presentation of inflammatory bowel disease (IBD) that manifests in childhood and adolescence and involves chronic and severe enterocolitis, immune and gut microbial dysregulation, and other complications. Diet and gut-microbiota-produced metabolites are sources of anti-inflammatories that could ameliorate symptoms. However, questions remain on how IBD influences biogeographic patterns of microbial location and function in the gut, how early life transitional gut communities are affected by IBD and diet interventions, and how disruption to biogeography alters disease mediation by diet components or microbial metabolites. Many studies on diet and IBD use a chemically induced ulcerative colitis model, …

Decrease Copd Readmissions With Aprn Interventions Using Agile Implementation, Andrea D. Conley Msn, Rn, Agcns-Bc, Mscrn

Nursing Publications, Posters, & Presentations

Abstract presented at the 2023 Nursing Research Symposium.

Objectives/Aim/Purpose

In September 2022 a team was established and tasked with decreasing COPD readmissions.

Review Of The Literature: Analysis Of The Effectiveness Of Mobile Integrated Health - Community Paramedicine Programs In Reducing Pre-Hospital Ems Calls And Transportations, Annika N. Schultz, Justin Gambini

Doctor of Medical Science (DMSc)

Pre-hospital Emergency Medical Service (EMS) systems, including fire departments and ambulance transport services, are increasingly overburdened with high call volumes and unnecessary utilization of services leading to provider burnout, depletion of resources and rising healthcare costs. Many local EMS systems have recognized a need for a more sustainable solution to help reduce the number of unnecessary 9-1-1 calls and transportation to the Emergency Department (ED). Local agencies are beginning to expand the role and scope of practice for paramedics through programs referred to as Mobile Integrated Health – Community Paramedicine (MIH-CP). This new branch of medicine aims to provide patient-centered …

"You Get What You Need When You Need It": A Mixed Methods Examination Of The Feasibility And Acceptability Of A Tailored Digital Tool To Promote Physical Activity Among Women In Midlife., Danielle Arigo, Jonathan Mathias Lassiter, Kiri Baga, Daija A Jackson, Andrea Lobo, Timothy C Guetterman

College of Science & Mathematics Departmental Research

During midlife (ages 40-60), women experience myriad changes that elevate their risk for cardiovascular disease (CVD), including decreased physical activity (PA). Women cite lack of social support for PA and lack of active peers who can serve as role models as key barriers. Digital tools such as web applications can provide exposure to these social inputs; they are also accessible in daily life and require modest time investment. However, as few tools have been designed to meet the unique needs of women in midlife with CVD risk, our research team previously built a web application that is tailored for this …

Bair Gown Evaluation Of Implementation: Patient Comfort, Surgical Site Infection, And Cost Analysis, Elizabeth Ringer Msn, Rn

Posters & Presentations

Poster presented at the Parkview Nursing Research Symposium, 2023.

It is a Perioperative (Periop) Standard of Care to maintain normothermia or a temperature above 36.0°C (96.9°F) for all patients receiving general anesthesia. The Parkview Randallia periop area has implemented a Bair Gown Active Warming System; this paper evaluates patient comfort, staff perception, surgical site infection (SSI) rate, and cost of said system. Previously, all patients would receive passive warming via warm blankets in preop and postop and active warming in the Operating Room (OR) via a Bair Hugger Blanket. The average preop temperatures were the same before and after implementation …

Adipose Tissue Dysregulation Leads To Chronic Systemic Inflammation, Jamie Rausch Phd, Rn

Posters & Presentations

IU School of Nursing Poster presented at Parkview Nursing Research Symposium 2023.

“Picture This!“: Innovative Approach To Hapi Reduction In A Surgical Trauma Neuro Icu​, Morgan Minnich Minnich Bsn, Rn, Cbis Sticu, Michelle Moss Asn, Rn, Ccrn Sticu, Janette Richardson

Posters & Presentations

Presented at the Nursing Research Symposium 2023

The primary purpose of this qualitative improvement project was to increase frequency of photos by bedside staff leading to a picture-perfect view and a story of the patient’s skin. Additionally, the purpose included:

• Decrease HAPI rate in STICU
• Develop Higher Standard of Care r/t Skin
• Educate patients and families on importance of skin r/t illness while hospitalized

Hapi: Reduction Steering Committee & Charter, Juli Johnson, Linda Francis, Cathy Warner, Cori Ames, Lorenzo Manquero, Brooke Randol Msn, Rn, Agcns-Bc, Cmsrn, Cws

Posters & Presentations

Poster presented at the Parkview Nursing Research Symposium 2023.

Stand up a multi-year project & charter aimed at decreasing the HAPI rate by 20%

Inspire. Explore. Embrace: A Recipe For Filling The Experience Complexity Gap, Mary Hunt Msn, Rn, Npd-Bc

Posters & Presentations

Poster presented at the Parkview Nursing Research Symposium, 2023

Purpose: The goal of the Student Nurse Program is to increase the applications to nursing schools, increase preparation of nursing students for clinicals, decrease the orientation time for new graduates, increase new graduate confidence, and first- year retention rate.

Evaluating Nursing Workflow & Satisfaction Through Patient Sleep Promotion On An Orthopedic Trauma Unit, Samantha Tiede Bsn, Rn

Posters & Presentations

Poster presented at Parkview Nursing Research Symposium, 2023.

Questioned the evidence and necessity around the nursing practice of routine, every four-hour, vital signs during bedtime hours in relation to nursing workflow, satisfaction, and staffing limitations.

Reviewed current staff opinions and personal practices regarding patient rest. Also identified miscellaneous physician orders used to direct patient sleep promotion.

Evaluated opportunities for sleep promotion resulting in the discovery of a “Sleep Bundle” pilot on the acute medical floors.

Adapted pilot to better suit the needs of the orthopedic trauma patient population.

Goal: Balancing nursing tasks and aiding in improved patient outcomes.

Reducing Hospital Utilizations For Urinary Tract Infections Through Education, Tiffany Ulmer Msn, Rn, Ccm, Danielle Adam Bsn, Rn, Amb-Bc

Posters & Presentations

Poster was presented at Parkview Nursing Research Symposium, 2023.

Population Health is a department within Parkview Health that uses care coordination services to improve patient outcomes, quality care, and patient satisfaction while reducing overall healthcare costs.

The purpose of this evidence-based project (EBP) was to identify or develop an educational tool to be used within the Population Health department to educate older adults at risk for developing UTIs. •The first goal was to increase awareness of early UTI symptoms and when to seek medical treatment. •The second goal was to increase awareness of the different evidence-based prevention strategies and other …

Skin Safety Bootcamp: Empowering Nurses To Own Hapi Prevention: A Quality Improvement Initiative, Brooke Randol Msn, Rn, Agcns-Bc, Cmsrn, Cws, Michelle Wood Msn, Rn-Bc

Posters & Presentations

Poster presented at Parkview Nursing Research Symposium, 2023

Question: For inpatient cardiovascular nurses, does implementing a skin safety bootcamp improve the use of pressure injury prevention interventions compared to preintervention, resulting in a decrease in hospital-acquired pressure injuries?

Enhancing Diabetes Care With Peer Mentorship And Support Groups, Barry Mccann Bsn, Rn

Posters & Presentations

Poster presented at the Parkview Nursing Research Symposium, 2023.

Continued increase in prevalence of type 2 diabetes indicates need for more effective interventions to support lifestyle and behavior changes (ADA 2018).

• Evidence indicates attending diabetes self management education programs can improve diabetes outcomes, unfortunately they are often under referred and underutilized (Powers et al. 2015, Boakye et al. 2018).

• Limited class times, locations, and capacities can make attendance for all patients difficult and vulnerable populations are less likely to participate (Boakye et al. 2018).

• Diabetes education programs often lack culturally and individually relevant guidance, provide no long-term …

Evaluating Effects Of Academic-Practice Partnerships A Literature Review, Katherine M. Edwards Msn, Rn, Ccrn-K

Posters & Presentations

Poster was presented at Parkview Nursing Research Symposium, 2023

Purpose of Project: ♦ Stakeholder satisfaction and benefits evaluated to understand what effects academic-practice partnership programs have on healthcare systems and nursing students ♦ Literature review was the method utilized to examine the effects of partnership programs for healthcare system and nursing student satisfaction

Raccoon Spatial Ecology In The Rural Southeastern United States, Jacob E. Hill, Madison L. Miller, James L. Helton, Richard B. Chipman, Amy Gilbert, University Of Georgia, Guha Dharmarajan, Olin E. Rhodes Jr.

United States Department of Agriculture Wildlife Services: Staff Publications

The movement ecology of raccoons varies widely across habitats with important implications for the management of zoonotic diseases such as rabies. However, the spatial ecology of raccoons remains poorly understood in many regions of the United States, particularly in the southeast. To better understand the spatial ecology of raccoons in the southeastern United States, we investigated the role of sex, season, and habitat on monthly raccoon home range and core area sizes in three common rural habitats (bottomland hardwood, upland pine, and riparian forest) in South Carolina, USA. From 2018–2022, we obtained 264 monthly home ranges from 46 raccoons. Mean …

Charting And Checking For Suicidality In A Family Medicine Residency Clinic, Bridget Murphy, Stacy Ogbeide

Journal of Human Services Scholarship and Interprofessional Collaboration

Suicide is a leading cause of death in the United States, and many individuals who die by suicide are likely to have seen a primary care physician (PCP) within the month of their death. Thus, the goal of this quality improvement (QI) project was to examine suicidality documentation practices of interprofessional clinicians within a Family Medicine residency clinic, thus providing rationale for continued research and a template for other clinics to emulate. The QI project used the Plan-Do-Study-Act cycle to survey 28 Family Medicine residents, faculty, and trainees for the Plan stage of the cycle in 2022 and assessed their …

A Novel Machine-Learning Framework Based On A Hierarchy Of Dispute Models For The Identification Of Fish Species Using Multi-Mode Spectroscopy, Mitchell Sueker, Amirreza Daghighi, Alireza Akhbardeh, Nicholas Mackinnon, Gregory Bearman, Insuck Baek, Chansong Hwang, Jianwei Qin, Amanda M Tabb, Jiahleen B Roungchun, Rosalee S Hellberg, Fartash Vasefi, Moon Kim, Kouhyar Tavakolian, Hossein Kashani Zadeh

Faculty, Staff and Student Publications

Seafood mislabeling rates of approximately 20% have been reported globally. Traditional methods for fish species identification, such as DNA analysis and polymerase chain reaction (PCR), are expensive and time-consuming, and require skilled technicians and specialized equipment. The combination of spectroscopy and machine learning presents a promising approach to overcome these challenges. In our study, we took a comprehensive approach by considering a total of 43 different fish species and employing three modes of spectroscopy: fluorescence (Fluor), and reflectance in the visible near-infrared (VNIR) and short-wave near-infrared (SWIR). To achieve higher accuracies, we developed a novel machine-learning framework, where groups of …

Medication Review Project For The Aspiring Ma Iii, Marie Millan

Articles, Abstracts, and Reports

No abstract provided.

Recent Incarceration, Substance Use, Overdose, And Service Use Among People Who Use Drugs In Rural Communities, Daniel B. Hoover, P. Todd Korthuis, Elizabeth Needham Waddell, Canyon Foot, Caitlin Conway, Heidi M. Crane, Peter D. Friedmann, Vivian F. Go, Mai T. Pho, Milan F. Satcher, Adams Sibley, Ryan P. Westergaard, April M. Young, Ryan Cook

Dartmouth Scholarship

Importance Drug use and incarceration have a substantial impact on rural communities, but factors associated with the incarceration of rural people who use drugs (PWUD) have not been thoroughly investigated.

Objective To characterize associations between recent incarceration, overdose, and substance use disorder (SUD) treatment access among rural PWUD.

Design, Setting, and Participants For this cross-sectional study, the Rural Opioid Initiative research consortium conducted a survey in geographically diverse rural counties with high rates of overdose across 10 US states (Illinois, Wisconsin, North Carolina, Oregon, Kentucky, West Virginia, Ohio, Massachusetts, New Hampshire, and Vermont) between January 25, 2018, and March 17, …

Global Variation In Diabetes Diagnosis And Prevalence Based On Fasting Glucose And Hemoglobin A1c, Ncd Risk Factor Collaboration (Ncd-Risc), Bin Zhou, Kate E. Sheffer, James E. Bennett, Edward W. Gregg, Goodarz Danaei, Rosie K. Singleton, Jonathan E. Shaw, Gladys Maestre, Jesus D. Melgarejo

School of Medicine Publications

Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed …

Social Activity Restriction And Psychological Health Among Caregivers Of Older Adults With And Without Dementia, Elliane Irani, Kylie Meyer, Scott Emory Moore, Kedong Ding

Faculty Scholarship

Objectives: We examined associations between social activity restriction and psychological distress and well-being for caregivers of older adults with and without dementia, and if the identified associations are different for the two groups. Methods: Using data from the 2017 National Study of Caregiving, we identified caregivers of older adults with (N = 541) and without (N = 1701) dementia. Linear regression models were estimated, adjusting for caregivers’ age, gender, race, education, relationship to care recipient, and self-rated health. Results: Restriction in visiting friends and family and attending religious services were associated with higher distress in dementia caregivers. Restriction in visiting …

Left Juxtaposition Of The Right Atrial Appendage: Pitfalls In Diagnosis, Kanya Singhapakdi, Wesam Sourour, Thomas Kimball

School of Medicine Faculty Publications

Several congenital anomalies of the right atrial appendage (RAA) have been described including aneurysm, herniation (in association with a pericardial defect), and left juxtaposition. The left juxtaposition of the RAA (LJRAA), first described by Birmingham in 1893 and subsequently introduced by Dixon in 1954, is usually associated with complex cardiac malformations such as obstruction of the left ventricular outflow tract. In this case report, we will describe an unusual variant of LJRAA in the absence of any other cardiac defects, which was initially misinterpreted as an aortic dissection. The correct diagnosis was made after careful reinterpretation and the use of …

Designing For Community Engagement: User-Friendly Refugee Wellness Center Planning Process And Concept, A Health Design Case Study, Ellen Solomon, Brandon Joa, Shandon Coffman, Billie Faircloth, Marc Altshuler, Bon Ku

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Refugee and immigrant populations have diverse cultural factors that affect their access to health care and must be considered when building a new clinical space. Health design thinking can help a clinical team evaluate and consolidate these factors while maintaining close contact with architects, patients' community leaders, and hospital or institutional leadership. A diverse group of clinicians, medical students, community leaders and architects planned a clinic devoted to refugee and immigrant health, a first-of-its-kind for South Philadelphia.

METHODS: The planning process and concept design of this wellness center is presented as a design case study to demonstrate how principles …

Raccoon Spatial Ecology In The Rural Southeastern United States, Jacob E. Hill, Madison L. Miller, James L. Helton, Richard B. Chipman, Amy T. Gilbert, James C. Beasley, Guha Dharmarajan, Olin E. Rhodes Jr.

United States Department of Agriculture Wildlife Services: Staff Publications

The movement ecology of raccoons varies widely across habitats with important implications for the management of zoonotic diseases such as rabies. However, the spatial ecology of raccoons remains poorly understood in many regions of the United States, particularly in the southeast. To better understand the spatial ecology of raccoons in the southeastern US, we investigated the role of sex, season, and habitat on monthly raccoon home range and core area sizes in three common rural habitats (bottomland hardwood, upland pine, and riparian forest) in South Carolina, USA. From 2018–2022, we obtained 264 monthly home ranges from 46 raccoons. Mean monthly …