Medicine and Health Sciences Commons^™

A Comparative Study Of Venezuelan Immigrants’ Pre- And Post-Migration Concerns For Their Children In The United States And Colombia, Aigerim Alpysbekova, Pablo Montero-Zamora, Mary H Soares, Carolina Scaramutti, Sumeyra Sahbaz, Maria Duque, Tara Bautista, Maria Fernanda Garcia, Christopher P Salas-Wright, Mildred M Maldonado-Molina, Melissa M Bates, Augusto Pérez-Gómez, Juliana Mejía Trujillo, Eric C Brown, Seth J Schwartz

Faculty, Staff and Student Publications

Research suggests that forced migration may lead to cultural stress and psychological distress. However, little is known about immigrant parents' pre- and post-migration concerns for their children's welfare. The present study examined the concerns of Venezuelan parents who migrated to the United States versus those who migrated to Colombia, and whether post-migration concerns were related to cultural stressors, mental health, and cultural identity. A sample of 609 Venezuelan immigrants completed surveys and responded to an open-ended prompt asking about pre- and post-migration concerns for children's welfare. Lack of safety was the most common pre-migration concern for Venezuelans in the U.S., …

Joint Problem-Solving Orientation, Mutual Value Recognition, And Performance In Fluid Teamwork Environments, Michaela Kerrissey, Zhanna Novikov

Faculty, Staff and Student Publications

INTRODUCTION: Joint problem-solving orientation (JPS) has been identified as a factor that promotes performance in fluid teamwork, but research on this factor remains nascent. This study pushes the frontier of understanding about JPS in fluid teamwork environments by applying the concept to within-organization work and exploring its relationships with performance, mutual value recognition (MVR), and expertise variety (EV).

METHODS: This is a longitudinal, survey-based field study within a large United States healthcare organization

RESULTS: Our results affirm a moderated mediation model wherein JPS enhances performance, both directly and through MVR; EV serves as a moderator in the JPS-MVR relationship. JPS …

Traumatic Tricuspid Regurgitation And Right Coronary Artery Dissection, Kan Chung Yan Joyce, Wong Chun Kit Martin

Journal of the Hong Kong College of Cardiology

Traumatic tricuspid valve regurgitation and coronary artery dissection are rare complications of blunt chest trauma. We report a case of acute severe traumatic tricuspid valve regurgitation and right coronary artery dissection in a young male patient with unremarkable medical history after a road traffic accident.

Dual Activity Of Aromatic And Heterocyclic Compounds As Anti-Inflammatory And Anticancer Promising Agents, Samar Said Fatahala, Rania Helmy Abd El-Hameed, Mosaad Sayed Mohamed, Neama Abdallah Abd El-Tawab

Trends in advanced sciences and technology

As the second leading cause of mortality worldwide, cancer poses a severe threat to human health. Chronic inflammation has recently been linked to an increased risk for a number of malignancies, suggesting that reducing inflammation could be a useful approach to both cancer prevention and treatment. This review delves into the connection between inflammation and cancer and outlines the current use of anti-inflammatory drugs as potentially effective cancer prevention and therapy strategies. we herein describe the main relation and the mechanisms underlying the anti-cancer outcomes of anti-inflammatory agents; namely Non-Steroidal Anti-inflammatory Drugs (NSAIDs), COX-2 inhibitors, LOX-inhibitors, Toll- inhibitors, and antioxidant …

Missed Medical Appointments And The Effect On Patient Care For African Americans Living With Hiv In Alabama, Perpetua Nazon

Walden Dissertations and Doctoral Studies

This quantitative correlational study examined the relationship between the independent variable of missed medical appointments and the dependent variables of race and gender for African American patients living with HIV/AIDS. Previous studies described the major issue that occurs with HIV patients is an increase of missed medical appointments, causing a panic for hospital administrators, who try to implement methods to reduce the rates of missed appointments. The study sample from the Center for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) database covered a total population of 14,521 African American males and females living with HIV in Alabama. Pearson’s …

A Multidisciplinary Approach To Managing Financial Toxicity In Oncology Patients, Katelin Muse

Walden Dissertations and Doctoral Studies

Patients with a cancer diagnosis are counseled at length about the standard of care treatment options, which may include surgery, radiation, anticancer medications, and chemo/immunotherapy through an informed consent process. Unfortunately, the potential economic burden and the accompanying psychological burden is seldom discussed up front. There is a significant need for routine screening and a multidisciplinary approach to the prevention of financial toxicity for the oncology patient. The purpose of this doctoral project was to lead an interprofessional team in the development of a clinical practice guideline for routine financial screening using the Comprehensive Score for Financial Toxicity (COST) tool …

Impact Of Traditional Education And Learner-Centered Education On Standardized Tests, Courtney Marie Winslow

Walden Dissertations and Doctoral Studies

There is a current shortage of approximately 45,000 nurses and nursing faculty to train student nurses, a number that is projected to grow. One proposed method to combat the shortage is to transition from traditional lecture-based classrooms to a learner-centered approach. Asking or requiring faculty to transition an entire nursing program from one teaching method to another without supporting data could be a waste of valuable time and resources. It could also prove detrimental to a program if students were unable to pass the NCLEX-RN exam, and a program was forced to close. The current study examined whether there was …

Structural And Functional Studies Of The Human Members Of The Macrophage Migration Inhibitory Factor Family, Andrew Parkins

University of the Pacific Theses and Dissertations

Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT) are the two human members of the MIF superfamily, which are implicated in an array of autoimmune disorders, inflammatory diseases, and cancer via their pleiotropic functionality. Despite only sharing 34% sequence identity, MIF and D-DT have high structural homology and overlapping functional traits, including activation of the type II cell surface receptor CD74 and keto-enol tautomerase activity. The MIF and/or D-DT-induced activation of CD74 leads to signaling cascades pivotal for cell growth, proliferation, and inhibition of apoptosis. Such characteristics make MIF and D-DT attractive molecular targets for drug discovery.

Currently, all …

Elaboration Of Diquinanes To Access Trifunctional Angular Triquinanes And Designed Dna Polymerase Α Inhibitors, Spencer M. Webber

University of the Pacific Theses and Dissertations

Natural products are of great significance to the pharmaceutical industry in the development of new drugs. Diquinane or bicyclo[3.3.0]octane is a conspicuous structural unit existing in the carbo-frameworks of a wide range of natural products such as alkaloids and terpenoids. These diquinane-containing molecules not only exhibit intriguing architectures, but also showcase a broad spectrum of significant bioactivities, which draw widespread attention from the global synthetic community. A more specific group of compounds containing a diquinane moiety with one extra 5-membered ring are called the angular triquinanes.In this work, we have developed a general synthetic scheme to the angular triquinanes. We …

Development Of Nano Formulations Of Lipophilic Platinum Complexes Against Lung Cancer, Zizhao Xu

University of the Pacific Theses and Dissertations

Lung cancer remains a leading cause of death worldwide and urges the development of more effective and safer treatment options. Conventional platinum-based drugs like cisplatin, while effective, are associated with significant systemic toxicity, particularly nephrotoxicity. Nano formulations, such as liposomal and micellar delivery systems, represent a promising approach to enhance the anticancer activity and reduce the toxicity of platinum complexes.

This study develops and evaluates novel miriplatin-loaded nano formulations for lung cancer therapy. We prepared and screened various liposomal and micellar formulations of miriplatin by either thin-film hydration or co-solvent evaporation, which identified a number of formulations with appropriate sizes …

Utilizing Ai Integrated Neuroimaging Technology To Expand Upon Machine Learning In Positron Emission Tomography Technology With The Aim Of Detecting Amyloid Beta Biomarkers Early In The Onset Of Alzheimer's., Ethan S. Terman

UROP Posters

Early intervention in Alzheimer's is vital for treatment. The earlier a professional can detect symptoms and make a diagnosis the earlier a prognosis can be implemented. With the prevalence of data in our day-to-day world combined with Artificial intelligence (AI), utilizing both for machine learning can pave the way for more accurate and efficient detection of Alzheimer's and other neurodegenerative diseases. AI combined with Machine learning (ML) increases diagnostic efficiency and reduces human errors, making it a valuable resource for physicians and clinicians alike. With the increasing amount of data processing and image interpretation required, the ability to use AI …

Neurodevelopmental Vulnerability To Gestational Ozone Exposure, Vishnupriya Alavala, Sarah E. Brent, Christopher G. Canal, Joseph Wang, Russell P. Hunter, Matthew J. Campen, Andrew K. Ottens

UROP Posters

Ambient air pollution accounts for about 4.2 million premature deaths annually per the World Health Organization. Ozone (O3) is a highly reactive air pollutant found in smog and is implicated in cellular damage leading to organ dysfunction. Ambient air pollution is associated with neurodevelopmental, behavioral, and cognitive disorders though ozone’s role is unknown. Studies here look at ozone exposure shortly after implantation vs. shortly before term to evaluate differences in neurodevelopmental susceptibility over time.

To inquire on the effects of ozone on the fetal brain, pregnant Sprague-Dawley rats were exposed once to 0.3 ppm of O3 or filtered air (FA) …

Raman Microspectroscopy For Detection Of Oral Potentially Malignant Disorders Using Minimally Invasive Brush Biopsy Samples, Isha Behl

Doctoral

Oral cancer is one of the most common cancers worldwide. The current gold standard for screening and diagnosis of oral premalignant and cancerous lesions is histopathological examination. Subjectivity is a major limitation of this technique, however. Other diagnostic methods exist, but they are not sensitive enough for early detection of potentially malignant disorders (PMDs), as these methods are based on morphological changes, which can occur late in malignant transformation. Raman spectroscopy, on the other hand, can provide molecular level information of the biological sample, through unique vibrational fingerprints of molecules. This is advantageous over the gold standard method, as molecular …

Ict-Enabled Change In Healthcare Organisations: Examining Implementation Practice Of Healthcare Documentation Projects, Selma Judia Furtado

Doctoral

No abstract provided.

Female Athletes With Better Psychological Readiness Are At Higher Risk For Second Acl Injury After Primary Acl Reconstruction, Ryan Zarzycki, Kathleen Cummer, Elanna Arhos, Matthew Failla, Jacob J. Capin, Angela H. Smith, Lynn Snyder-Mackler

Physical Therapy Faculty Research and Publications

Background: Approximately 1 in 4 athletes returning to sports will sustain a second anterior cruciate ligament (ACL) injury. Psychological factors related to kinesiophobia, confidence, and psychological readiness are associated with second ACL injury; however, the evidence is conflicting.

Hypothesis: Athletes who sustain a second ACL injury (ie, graft rupture or contralateral ACL rupture) within 2 years of ACL reconstruction (ACLR) would have greater kinesiophobia, less confidence, and lower psychological readiness prior to return to sport (RTS) compared with athletes who do not sustain a second ACL injury.

Study Design: Secondary analysis of a prospective randomized trial.

Level …

Age-Related Development Of Bilateral Coordination Of The Upper Limbs In Children And Adolescents, Samuel Nemanich, Sheila M. Schindler-Ivens

Physical Therapy Faculty Research and Publications

Bilateral coordination of the upper limbs (UL) is important for activities of daily living and physical activities. Motor coordination improves from childhood through adolescence. However, age-coordination trajectories for bilateral UL movements are not well-established, and it is unclear if bimanual coordination develops slower than unilateral coordination. In this study we examined age-related changes in UL coordination from childhood to late adolescence. Typically-developing children (N = 29, aged 7–17 years) performed unilateral and bilateral, antiphase cycling tasks with their ULs. Variations in cycling velocity and interlimb phase errors were computed as measures of coordination. Linear regression was used to examine …

The Effects Of Attentional Focus Instructions On Approach Jump Performance, Hanwen Liu, Scott Arnett, Dano Tolusso, Kaylee Woodard

Physical Therapy Faculty Research and Publications

Introduction

Attentional focus has been shown to significantly influence motor learning and performance, with external focus instructions enhancing performance compared to internal focus instructions. Research has also demonstrated that novice performance is improved when instructed to focus on skill execution processes rather than outcomes. However, this effect remains untested in complex jumping skills crucial to numerous sports.

Purpose

This study aimed to investigate the effect of internally and externally directed process and outcome focus instructions on approach jump height and approach speed in novice participants.

Methods

Twelve individuals aged 18 to 22 participated across three sessions: Familiarization, Test Session 1, …

Heart Rate Variability Is Reduced In Covid-19 Survivors And Associated With Physical Activity And Fatigue, Michael H. Haischer, Lauren E. Opielinski, Lindsey M. Mirkes, Toni D. Uhrich, Rachel E. Bollaert, Michael E. Danduran, Marie K. Hoeger Bement, Linda B. Piacentine, Paula E. Papanek, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Reduced heart rate variability (HRV) and fatigue are common after COVID-19 infection and both are potentially influenced by physical activity (PA). We compared resting HRV, PA from accelerometers and questionnaires, and self-reported fatigue in 41 COVID-19 survivors (~8 months postinfection, 38 ± 17 years) with 41 matched controls. Differences in HRV were observed on acceleration capacity (p = 0.041), deceleration capacity (p = 0.032), high-frequency peak frequency (p = 0.019), absolute low-frequency power (p = 0.042), relative very low-frequency power (p = 0.012), SD2 (from Poincare plot; p = 0.047), and DFA2 (slope of long-term …

Middle-Range Scores From The Patient Determined Disease Steps Scale Reflect Varying Levels Of Walking Dysfunction In Multiple Sclerosis, Robert W. Motl, Whitney Neal, Deborah Backus, Jeffrey Hebert, Kevin K. Mccully, Francois Bethoux, Prudence Plummer, Alexander V. Ng, John Lowman, Hollie Schmidt, Robert Mcburney, Gary R. Cutter

Exercise Science Faculty Research and Publications

Background

Multiple sclerosis (MS) is a leading cause of neurological disability among young and middle-aged adults worldwide, and disability is measured using a variety of approaches, including patient reported outcome measures (PROMs) such as the Patient Determined Disease Steps (PDDS) scale. There is limited evidence for the validity of inferences from the middle-range of scores on the PDDS (i.e., 3 “gait disability” – 6 “bilateral support”), but that range of scores seemingly represents moderate disability characterized by varying levels of walking dysfunction.

Purpose

The current study examined whether the middle-range of scores from the PDDS reflect varying levels of walking …

On The Area-Averaged Effective Sound Absorption Coefficient Of Porous Materials Excited By A Monopole, Franck Sgard, Noureddine Atalla, Olivier Robin, Alain Berry

Études primaires

The area-averaged effective sound absorption coefficient (SAC) of a rigid-backed homogeneous porous material subjected to a monopole excitation is calculated as the absorbed-to-incident sound power ratio. Using Allard's model to describe the sound propagation above the porous material, an analytical model for this power-based SAC is proposed and proves to give a good approximation of the sound absorption performance under monopole excitation of sufficiently large areas of material. The impact of factors on the power-based SAC, such as monopole height, material radial dimension used to calculate the sound powers, and material properties is discussed. The power-based SAC frequency-dependent behavior is …

Measurement Of The Local Static Mechanical Pressure Of Earplugs, Luiz G.C. Melo, Ahmed S. Dalaq, Franck Sgard, Olivier Doutres, Laurianne Legroux, Eric Wagnac

Études primaires

Earplugs are used in various critical industrial sectors, such as construction, aviation, military and defense, transportation, and healthcare. However, they present inherent drawbacks, notably discomfort that can lead to inconsistent and incorrect use, thereby leaving a significant proportion of workers vulnerable to irreversible hearing damage, ranging from tinnitus to deafness. This discomfort is closely linked to a physical parameter known as static mechanical pressure (SMP), representing the pressure exerted by earplugs on the earcanal walls. Determining the SMP is crucial for developing earplugs that prioritize comfort. However, experimental studies in this area are scarce and there is no experimental set-up …

Disability Reduction Following A Lumbar Stabilization Exercise Program For Low Back Pain: Large Vs. Small Improvement Subgroup Analyses Of Physical And Psychological Variables, Christian Larivière, Richard Preuss, Marie-France Coutu, Michael J. Sullivan, Nicolas Roy, Sharon M. Henry

Études primaires

Background: Little is known about why patients with low back pain (LBP) respond differently to treatment, and more specifically, to a lumbar stabilization exercise program. As a first step toward answering this question, the present study evaluates how subgroups of patients who demonstrate large and small clinical improvements differ in terms of physical and psychological changes during treatment. Methods: Participants (n = 110) performed the exercise program (clinical sessions and home exercises) over eight weeks, with 100 retained at six-month follow-up. Physical measures (lumbar segmental instability, motor control impairments, range of motion, trunk muscle endurance and physical performance tests) were …

An Impedance Tube Technique For Estimating The Insertion Loss Of Earplugs, K. Carillo, O. Doutres, F. Sgard

Études primaires

This paper proposes a quick and straightforward technique for estimating the insertion loss (IL) of earplugs measured on an acoustical test fixture (ATF) using a commercial impedance tube. In this method, the earplug's acoustic properties (i.e., its transmission loss and the reflection coefficient of its medial surface) are determined from its transfer matrix measured using the three-microphones impedance tube method modified here for the current application. The IL is then estimated using a one-dimensional analytical model of open and occluded earcanals based on the wavefield decomposition theory. The method is evaluated numerically and experimentally from 50 Hz to 6.5 kHz. …

Excess Risk Of Covid-19 Infection And Mental Distress In Healthcare Workers During Successive Pandemic Waves: Analysis Of Matched Cohorts Of Healthcare Workers And Community Referents In Alberta, Canada, Jean-Michel Galarneau, France Labrèche, Quentin Durand-Moreau, Shannon Ruzycki, Anil Adisesh, Igor Burstyn, Tanis Zadunayski, Nicola Cherry

Études primaires

Objectives: To investigate changes in risk of infection and mental distress in healthcare workers (HCWs) relative to the community as the COVID-19 pandemic progressed. Methods: HCWs in Alberta, Canada, recruited to an interprovincial cohort, were asked consent to link to Alberta’s administrative health database (AHDB) and to information on COVID-19 immunization and polymerase chain reaction (PCR) testing. Those consenting were matched to records of up to five community referents (CRs). Physician diagnoses of COVID-19 were identified in the AHDB from the start of the pandemic to 31 March 2022. Physician consultations for mental health (MH) conditions (anxiety, stress/adjustment reaction, depressive) …

Comparative Evaluation Of Different Spinal Stability Metrics, Amir Hossein Eskandari, Farshid Ghezelbash, Aboulfazl Shirazi-Adl, Christian Larivière

Études primaires

Direct in vivo measurements of spinal stability are not possible, leaving computational estimations (such as dynamic time series and structural analyses) as the feasible option. However, differences between different stability assessment approaches and metrics remain unclear. To explore this, we asked 32 participants to perform 35 cycles of repetitive lifts with and without load (4/2.6 kg for males/females). EMG signals and 3D kinematics were collected via 12 surface electrodes and 17 inertial sensors, and three dynamical stability measures were computed: short and long temporal and conventional maximum Lyapunov exponents (LyE) and maximum Floquet multipliers (FM). A dynamic subject-specific EMG-assisted musculoskeletal …

Occupational Pressures Of Frontline Workers Enforcing Covid-19 Pandemic Measures In Ontario And Quebec, Canada, Pamela Hopwood, Ellen Maceachen, Daniel Côté, Samantha B. Meyer, Shannon Majowicz, Ai-Thuy Huynh, Meghan K. Crouch, Joyceline Amoako, Yamin T. Jahangir, Amelia León Correal, Antonela Ilic

Études primaires

BACKGROUND:During the COVID-19 pandemic, low-wage public-facing frontline workers (FLWs), such as grocery store clerks, were required to monitor retail customers and enforce COVID-19 protocols. OBJECTIVE:This analysis aimed to examine FLWs experiences of enforcing COVID-19 pandemic measures. METHODS:Between September 2020 and March 2021, in Ontario and Quebec (Canada), we conducted in-depth interviews about customer-related work and health risks with FLWs who interacted with the public (n = 40) and their supervisors (n = 16). Using a lens of situational analysis, verbatim transcripts were coded according to recurring topics. RESULTS:We found that enforcing public health measures placed already-precarious workers in difficult occupational …

What Are The Perceptions And Lived Experiences Of Canadian Injured Workers About The Provision Of Physiotherapy Services Using Telerehabilitation?, Anne Hudon, Maxi Miciak, Teri Slade, Stacey Lovo, Jackie L. Whittaker, Daniel Côté, Debbie E. Feldman, Dahlia Kairy, Marie Laberge, Beverley Mckeen, Lynn Cooper, Douglas P. Gross

Études primaires

Purpose

Despite evidence of efficacy, the effectiveness of telerehabilitation in real-world clinical settings is still largely unknown. Telerehabilitation requires a substantial transformation of the organization and delivery of traditional services. Considering that a virtual setting can create unique challenges for providing physiotherapy services and given the physical and potential hands-on nature of evidence-based assessments and interventions, it is important to investigate what injured workers think of receiving physiotherapy care via telerehabilitation and to examine if rehabilitation needs are adequately met.

Methods

A qualitative interpretive description study was conducted to explore the perspectives and experiences of 17 injured workers receiving physiotherapy …

Les Pratiques Professionnelles Des Pomiculteurs Exposés Aux Pesticides : Des Savoir-Faire De Métier Aux Pratiques Stratégiques, Caroline Jolly, Alain Garrigou, Elise Ledoux

Études primaires

Dans les très petites entreprises pomicoles, le propriétaire assume majoritairement seul la préparation et la pulvérisation des pesticides. Le respect des mesures de prévention prescrites n’élimine pas l’exposition, pouvant occasionner des effets à la santé. L’objectif est de décrire les pratiques professionnelles développées par les pomiculteurs. Elles visent à limiter l’exposition aux pesticides tout en produisant des fruits de qualité, contribuant ainsi à l'essor de leur entreprise. La recherche-intervention mobilisant l’ergotoxicologie a été réalisée auprès de pomiculteurs au Québec. La diversité des pratiques professionnelles présentées s’inscrit dans les domaines d’activités de la gestion stratégique (p. ex. : développement de l’entreprise) …

The Role Of Age As A Risk Factor For Pickleball-Related Injuries, Ches Jones, Bart Hammig

Health, Human Performance and Recreation Faculty Publications and Presentations

Pickleball is a popular sport that includes players from many different demographics. The popularity has resulted in not only increases in participation but also in activity related injuries. The purpose of this study was to identify risk factors along with potential mechanisms for injuries related to pickleball and identify effective countermeasures. Methods included the identification of pickleball related injuries from a US National Emergency Room database (NEISS). A narrative section of the database was used to identify and categorize potential mechanisms of injury. Results indicated that the types and mechanisms of injury relate to three specific age groups: younger, middle …

Preclinical Study And Parallel Phase Ii Trial Evaluating Antisense Stat3 Oligonucleotide And Checkpoint Blockade For Advanced Pancreatic, Non-Small Cell Lung Cancer And Mismatch Repair-Deficient Colorectal Cancer, Chad Tang, Genevieve P Hartley, Coline Couillault, Ying Yuan, Heather Lin, Courtney Nicholas, Anupallavi Srinivasamani, James Dai, Ecaterina E Ileana Dumbrava, Siqing Fu, Daniel D Karp, Aung Naing, Sarina A Piha-Paul, Jordi Rodon Ahnert, Shubham Pant, Vivek Subbiah, Timonthy A Yap, Apostolia M Tsimberidou, Paola Guerrero, Sarah Dhebat, Theresa Proia, Michael A Curran, David S Hong

Faculty, Staff and Student Publications

Objective: To evaluate signal transducer and activator of transcription 3 (STAT3) inhibition we conducted a co-clinical trial testing danvatirsen, a STAT3 antisense oligonucleotide (ASO) and checkpoint inhibition in conjunction with preclinical experiments.

Methods and analysis: Orthotopically implanted pancreatic cancer (pancreatic adenocarcinoma (PDAC)) was treated with STAT3 ASO with immune checkpoint inhibition. Tumour infiltrating immune cell populations were characterised via flow cytometry. In vitro experiments evaluated STAT3 inhibition in pancreatic stellate cells (PSCs) and myeloid-derived suppressor cells (MDSCs).A phase II trial employing a Simon II stage design tested the clinical efficacy of danvatirsen and durvalumab in non-small cell lung cancer (NSCLC), …