Medicine and Health Sciences Commons^™

Behaviours And Psychological Symptoms Of Childhood Dementia: Two Cases Of Psychosocial Interventions, Mustafa Atee, Ineka Whiteman, Rebecca Lloyd, Thomas Morris

Research outputs 2022 to 2026

Childhood dementias are a group of rare, fatal neurodegenerative disorders, characterised by global cognitive decline, loss of previously acquired developmental skills and behaviours and psychological symptoms of dementia (BPSD). Batten disease, or neuronal ceroid lipofuscinosis, and Sanfilippo syndrome, or mucopolysaccharidosis type III, are two of the more common forms of childhood dementia disorders worldwide. While psychosocial interventions are the best available therapeutic approach for BPSD management in adult-onset dementia, there is very limited literature or clinical experience in the context of childhood dementia. To address this gap, we conducted a descriptive case analysis of BPSD profiles, associated contributing factors and …

Twin Scholarships Of Glycomedicine And Precision Medicine In Times Of Single-Cell Multiomics, Seungyoul Oh, Weijie Cao, Manshu Song

Research outputs 2022 to 2026

Systems biology and multiomics research expand the prospects of planetary health innovations. In this context, this mini-review unpacks the twin scholarships of glycomedicine and precision medicine in the current era of single-cell multiomics. A significant growth in glycan research has been observed over the past decade, unveiling and establishing co- and post-translational modifications as dynamic indicators of both pathological and physiological conditions. Systems biology technologies have enabled large-scale and high-throughput glycoprofiling and access to data-intensive biological repositories for global research. These advancements have established glycans as a pivotal third code of life, alongside nucleic acids and amino acids. However, challenges …

The Joint Effects Of Cognitive Function And Sedentary Time On Mortality Risk In Older Adults: 2011-2014 Nhanes, Sarah A. Wilson

UNF Graduate Theses and Dissertations

Background: Examining the joint effects of cognitive function (CF) and sedentary time (ST) may provide insight into the complex mechanisms underlying mortality risk within older adults. This study examines the joint effects of CF and ST on mortality risk in older adults.

Methods: Sample included 2,230 older adults (≥ 60 years of age) participants in the 2011-2014 National Health and Nutrition Examination Survey. The Digit Symbol Substitution Test (DSST), Consortium to Establish a Registry for Alzheimer's Disease (CERAD) subtests, and Animal Fluency (AF) were used to assess CF. Average daily sitting and television time represented ST. Quartiles of CF and …

Use Of Hydroxychloroquine In Multidrug Protocols For Sars-Cov-2, Eleftherios Gkioulekas, Peter A. Mccullough

School of Mathematical & Statistical Sciences Faculty Publications

We review the available evidence supporting the use of hydroxychloroquine-based multidrug protocols in the treatment of COVID-19, in response to a recently published editorial in the Tasman Medical Journal.

Health Policies Within The Poverty Agendas Of Lula And Rousseff, Welington Lazarini, Francis Sodré, Carlos Eduardo Siqueira

Gastón Institute Publications

The anti-poverty agenda has been at the heart of the World Bank’s discourse in recent decades. Social policies started to be identified as strategic for combating poverty and promoting development in poor countries. We analyzed the health policy recommendations made by the World Bank to Brazil in the Lula da Silva and Rousseff administrations from 2003 to 2014. Document analysis was used to explore the partnership contracts between the World Bank and Brazil, projects financed by the World Bank in Brazil, and the document “20 Years of Construction of the Health System in Brazil: An Analysis of the Unified Health …

Testing The Strength Of Thin Feather-Edge Monolithic Multilayered Zirconia Crowns: A Pilot Study With A Novel Acoustic Test, Estelle Saab, Camille Haddad, Maher Abboud, Maha Daou, Amine Zoghbi

International Arab Journal of Dentistry

Introduction: Limited research has explored the mechanical characteristics of recently introduced multilayered monolithic zirconia (MZC) crowns with feather-edge margins design. Moreover, most of the conventional techniques for evaluating the mechanical behavior of brittle dental ceramics rely on destructive tests, making it impossible to precisely evaluate real strength values due to premature crack initiation detection failure.

Objectives: The main objective of the study was to assess the load capacity of translucent multilayered monolithic zirconia crowns with feather-edge margin thicknesses of 0.4 mm and 0.5 mm. Additionally, the research introduced a novel non-destructive acoustic emission testing (AET) technique in the …

The Role Of Neutrophil-To-Lymphocyte Ratio (Nlr), Lymphocyte-To-Monocyte Ratio (Lmr), And Platelet-To-Lymphocyte Ratio (Plr) In Oral Cancer And Acute Dental Infections, Sasti Priya Govindasamy Sukumar, Ravikumar Pethagounder Thangavelu, Karthik Rajaram Mohan, Ramachandra Reddy Gowda Venkatesha, Kumar Appusamy

International Arab Journal of Dentistry

Objectives: The present study was a cross-sectional observational study, which was carried out on patients reported to the Department of Oral Medicine and Radiology. This study aims to evaluate the hemogram parameters NLR, LMR, and PLR among 90 Patients.

Methods: Patients were divided into 3 groups: Group A consists of 30 patients with histopathological confirmed oral cancer. Group B consists of 30 patients who presenting acute dental infections. Group C consists of 30 patients clinically healthy subjects. The hemogram parameters NLR, LMR and PLR were compared in the 3 groups and we studied their correlation to the clinical …

Bone-To-Implant Surface Contact As A Criterion For Immediate Implant Placement With Simultaneous Sinus Augmentation In The Upper Molars' Interradicular Bone: A Radiological Cbct Study, Nawal Baba, Nabil Ghosn, Abdel Rahman Kassir, Lara Nasr, Gabriel Menassa, Carole Chakar

International Arab Journal of Dentistry

Objectives: The aim of this study is to determine which type of vertical relationship (between molar apices and the sinus floor) is correlated with the most favorable bone to implant contact (BIC).

Methods: The CBCT database of the Faculty of Dental Medicine was used for datasets. For each dataset, a prosthetically-driven virtual implant placement was placed in the remaining interradicular bone. Potential BIC was measured using two different implant macrogeometries (straight and tapered).

Results: The study included 20 maxillary molars with divergent root anatomy: 90% of the molars had a type II vertical relationship with the sinus …

Ai And Radiologist Assessments On The Prevalence Of Tmj Osteoarthritis Using Radiographic Images: A Comparative Study, Louloua Mourad, Nayer Abo El Saad, Yehia El Mahallawy

International Arab Journal of Dentistry

Objectives: This study aims to address the significant discomfort and functional impairment associated with temporomandibular joint osteoarthritis (TMJ OA), which negatively impacts the quality of life. It emphasizes the importance of prompt diagnosis and explores the potential of an Artificial Intelligence (AI) system to enhance TMJ OA diagnosis.

Methods: The prevalence of TMJ OA was evaluated using 3 diagnostic tools: the gold standard, the AI model, and an examiner. In total, 132 patients who performed 190 cone-beam computed tomography (CBCT) images were included.

Results: The prevalence of TMJ OA was 62.11% using the gold standard, 63.68% using …

Clinical Assessment Of The Abutment Teeth Of Children Undergoing Space Maintainer Therapy: A Randomised Controlled Trial, Ayesha Fathima, Ganesh Jeevanandan, Prabhadevi Maganur, Suman Panda, Ather Syed Ahmed, Satish Vishwanathaiah

International Arab Journal of Dentistry

Introduction: The band and loop space maintainer are one of the most commonly used fixed space maintainers in children. However, prolonged use of appliances in the oral cavity may lead to changes in gingival health and an increased risk of caries.

Objectives: This study aims to evaluate the clinical parameters of the abutment teeth, specifically the banded teeth and the tooth to which the loop is extended.

Methods: This prospective clinical study included 35 children between the age group of 5 to 9 years. The children were examined at baseline and 6-month follow-up. The abutment teeth were …

Comparative Evaluation Of Surface Changes And Bond Strength Of Microabrasion-Bleached Enamel Before And After Remineralization With Nano-Hydroxyapatite Paste: An In Vitro Study, Ridhi Dube, Anita Sanap Tandale, Twinkle Kishore Talreja, Karishma Krishnakumar, Prajakta Kokate, Vaishnavi Jemini Kasat

International Arab Journal of Dentistry

Objectives: Comparative evaluation of surface changes and bond strength of Microabrasion Bleached enamel before and after Remineralization with Nano-hydroxyapatite paste, an In vitro study.

Methods: Enamel samples were divided into - Group I - Conventional bleaching (HB), Group II - Conventional bleaching with remineralization (HB+N-Hp), Group III - Microabrasion-assisted bleaching(M+HB), and Group IV - Microabrasion-assisted bleaching with remineralization(M+HB+NHp). Surface roughness was measured using a profilometer. Samples were stored in artificial saliva for two weeks, then bonded with nanofilled composite resin and subjected to shear bond strength (SBS) analysis.

Results: Group IV (M+HB+N-Hp) showed higher surface roughness than …

Diagnosis And Endodontic Treatment Of Odontogenic Cutaneous Sinus Tracts: A Report Of Two Cases, Mayada Jemâa, Marwenne Bouatay, Yesmine Neifar, Mohamed Bassem Khattech

International Arab Journal of Dentistry

Introduction: The odontogenic cutaneous sinus tract (OCST), caused by pulp necrosis, creates connections between pathological spaces and anatomical structures. Extraoral manifestations pose diagnostic challenges leading to inappropriate treatments such as multiple surgery and antibiotic therapies. Effective management requires the treatment of dental pathology through endodontic therapy or extraction. This paper presents two cases of OCST and emphasizes the importance of accurate diagnosis and successful non-surgical endodontic treatment.

Observations: Case report 1: A 23-year-old male patient referred by his dermatologist with a cutaneous sinus tract on his chin that had appeared five years ago. During this period, he reported …

Clinical Management Of Mandibular Permanent Premolars With Periapical Lesion And Bilateral Supernumerary Teeth: A 7-Year Follow-Up Case Report, Chiara Pirani, Shehabeldin Saber, Francesco Iacono

International Arab Journal of Dentistry

Objectives: This 7-years follow-up case report describes two diversified strategies for the management of bilateral mandibular permanent premolars associated with periapical lesion and unerupted supernumerary teeth.

Case Report: A non-syndromic 9 years-old Asian female patient presented pain and swelling of the 35 in anatomical contiguity with an immature and unerupted supernumerary tooth. Clinical examination revealed an intraoral vestibular sinus tract related to the necrotic 35. Periapical radiography and CBCT showed that the 35 had an immature apex associated with a periapical lesion, and a supernumerary tooth in a lingual direction. Endodontic treatment of the 35 was performed by creating …

Endocrown, From Preparation To Bonding: Case Report, Amira Yousfi, Rihab Dakhli, Jilani Saafi, Belhassen Harzallah

International Arab Journal of Dentistry

The restoration of endodontically treated teeth is a real challenge, particularly teeth with extensively damaged coronal tissues. The use of post-retained restorations has been discussed because of the potential tooth weakening due to the additional removal of sound dental structures. In fact, long-term prognosis of a devitalized tooth is closely related to the coronal restoration’s quality and the remaining dental structure. With the development of adhesive dentistry and minimally invasive preparation, new approaches have emerged. Among them, the endocrown which is monolithic ceramic bonded restoration, anchored to the internal portion of pulp chamber and cavity margins that have been used …

Does The Application Of Polywave Light-Curing Units Influence Physico-Mechanical Properties Of Resin-Based Materials? A Meta-Analysis Of In Vitro Studies, Miguel Ángel Fernández-Barrera, Rim Bourgi, Abigailt Flores-Ledesma, Cristina Pereira Isolan, Vincenzo Tosco, Bogdan Dimitriu, Carlos Enrique Cuevas-Suárez, Monika Lukomska-Szymanska, Louis Hardan

International Arab Journal of Dentistry

The objective of this study was to systematically review the existing literature and to assess the effect of the use of polywave light-curing units on the properties of resin-based materials. A thorough search was conducted across five electronic databases: PubMed (MedLine), ISI Web of Science, SciELO, Scopus, and EMBASE. Inclusion criteria comprised in-vitro studies that compared the effects of polywave light-emitting diode (LED) curing units with monowave LED curing units on resin-based material properties. Two reviewers evaluated the methodological quality of the included studies, considering parameters from previous systematic reviews. Meta-analyses were conducted using Review Manager version 5.3.5 (The Cochrane …

Psychedelic Expectancies And Post-Traumatic Stress Disorder Symptoms, Samantha Gomez

Electronic Theses & Dissertations (2024 - present)

Millions of Americans struggle with posttraumatic stress disorder (PTSD) every year. Though typical treatments work for some, patients often drop out of treatment. Given that patients are often retelling their traumatic experiences, or confronting stimuli and situations that are relevant to the experience, psychotherapy for PTSD can be psychologically demanding and intensive. These factors provide a further understanding for the high rates of PTSD treatment attrition. Psychedelic assisted psychotherapy (PAP) is a potential option to mitigate these concerns. Preliminary research on PAP has revealed effective and promising results. However, questions about PAP and their public perception remain. Furthermore, treatment expectancies, …

Hospital Surge Capacity In Co-Occurring Mass Casualty Incidents, Carolyn Solimine

Electronic Theses & Dissertations (2024 - present)

The COVID-19 pandemic has brought sweeping disruption and changes across healthcare systems. Examining how these changes have impacted surge capacity and capabilities is necessary to plan for future co-occurring surge-creating events in hospital Emergency Departments (EDs) and Intensive Care Units (ICUs). While there is extensive research on patient surge management, no study has looked at how the presence of a prolonged surge would impact the healthcare system’s ability to handle a concurrent acute patient surge. This study seeks to demonstrate the need for comprehensive planning for co-occurring patient surges in New York State using hospital capacity data from Health and …

Assessing Associations Between Emergency Room Visits For Respiratory And Cardiovascular Diseases And Criteria Air Pollutants Exposure In New York State, Tamba Solomon Lebbie

Electronic Theses & Dissertations (2024 - present)

Abstract

Air pollution is a major environmental health hazard for the general population. Approximately 90% of the global population is at risk of both indoor and outdoor air pollution, and it accounts for an estimated 7 million premature deaths every year according to the World Health Organization (WHO). Multiple studies including epidemiological and molecular analyses have confirmed the negative effects of air pollutants on human health even at levels within the WHO guidelines. This study examines the health impacts of releases of criteria air pollution from point sources in New York State (NYS). There is evidence from population studies that …

Optimizing The Community Health Worker (Chw) Program In Belize And Understanding Its Unique Intermediary Position Within The Health System: Perspective From The World Health Organization (Who) Health Systems Approach, Andrei R. Chell

Electronic Theses & Dissertations (2024 - present)

Human resources for health (HRH) are the backbone of a well-functioning and resilient health system. Issues related to HRH recruitment, retention, planning, leadership and governance have been amplified by the coronavirus disease 2019 (COVID-19) pandemic and have posed additional and unprecedented challenges in many countries. Community health workers (CHWs) in particular, are uniquely positioned to be frontline health care workers (HCWs) that are considered a vital link between communities and the formal health system. Globally, the benefits of CHW programs have been well documented, and there is substantial evidence of the efficacy and effectiveness of these programs. However, countries are …

The Effect Of Presenting Concerns On Providers’ Assessment Of Patients' Suicide Risk, Alexandria Brunkow

Electronic Theses & Dissertations (2024 - present)

Objective: Suicide is the 10^th leading cause of death in the U.S. with nearly 50,000 people per year dying by suicide. Public health approaches to suicide prevention focus on screening people in primary and mental health care settings and offering treatment to those who screen positive. Research shows that mental health providers may not recognize risk factors for suicide and miss opportunities to screen patients who may be at risk. Providers’ mental representations of suicide risk may be influencing their perception of patient risk and contributing to low screening rates. This study used an experimental vignette case design to …

Ribosome Hibernation Factor Induces Antibiotic Persisters Of Mycobacterium Tuberculosis In Neutrophil-Rich Lung Lesions, Jamie Corro

Electronic Theses & Dissertations (2024 - present)

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is a prescient global health threat and the leading cause of death by an infectious agent. Treatment of Mtb infection involves administering 2-4 antibiotics for a minimum of 6 months. This extended drug regimen is required to target a subpopulation of persistent bacilli. As their name implies, these bacteria can “persist” by acquiring nonhereditary and transient antibiotic tolerance. Although the precise mechanism is unknown, it’s often attributed to slowing cellular growth and metabolic processes. During zinc deprivation, bacteria can remodel their ribosomes by replacing their zinc-binding paralogues containing the CXXC motif (C+) …

A Descriptive Analysis Of Depressive Symptoms And Body Image By Race/Ethnicity And Nativity Status Among Adolescents, Radhika Prasad

Electronic Theses & Dissertations (2024 - present)

Previous research on the immigrant health paradox among children and adolescents show a mental health advantage yet it is unclear if this applies in a similar magnitude to females (Fillion et al., 2018; Zarei et al., 2023). Immigrants may be exposed to stressors related to immigration and acculturation. Some research suggests that females respond more to stress through internalizing symptoms relative to males (Hall-Lande et al., 2007; Adkins et al., 2009). Given these gender differences in stress response, female immigrants may be particularly vulnerable to the psychological consequences of immigration related stressors. The immigrant health paradox has also overlooked subjective …

Advancing Small Molecule Therapies For Myotonic Dystrophy Type 1, Sawyer M. Hicks

Electronic Theses & Dissertations (2024 - present)

Myotonic dystrophy type 1 (DM1) is a multisystemic disorder caused by the expression of expanded CUG (CUG^exp) repeat RNA from the myotonic dystrophy protein kinase (DMPK) gene. This CUG^exp repeat RNA’s gain-of-function mechanism leads to the sequestration of muscleblind-like (MBNL) proteins, resulting in widespread alternative splicing dysregulation across tissues. Despite significant research, there are currently no approved therapeutics targeting the underlying causes of DM1. This dissertation explores the development and optimization of a novel class of small molecules, Modified Polycyclic Compounds (MPCs), designed to address splicing dysregulation in DM1. MPCs were designed from previously published …

Clearing Ethnic Minority Roadblocks To Entry Into The Field Of Dietetics: A Mixed Analysis, Lisa C. Best

UNF Graduate Theses and Dissertations

Background - Dietitians are represented by fewer than 3% African Americans and 6% Hispanics compared with population demographics of 13% and 19% respectively. Despite 50 years of research on pipeline education, mentorship programs, cultural competency, and funding opportunities, minority participation in dietetics remains disproportionately low. At a time of increasing health care disparity, it is more important than ever to recruit and retain minorities in dietetics to optimally serve an ever increasingly diverse population.

Methods - 18 Historically Black Colleges and 26 high Hispanic census schools nationwide were contacted by email and follow-up phone call to explore and address ethnic …

Food Insecurity And Eating Disorders In College Students: Two Scoping Reviews, Barbara Jan Goldman

UNF Graduate Theses and Dissertations

Objective: These scoping reviews explore the broad body of research post-secondary students experiencing food insecurity and eating disorders, to identify trends and gaps to inform future research.

Methods: Three search engines (PubMed, Web of Science, and CINHAL Full Text) were systematically searched for articles reporting on food security status in U.S. college students for manuscript one and post-secondary students experiencing food insecurity and maladaptive eating behaviors or eating disorders for manuscript two.

Results: One-hundred and sixty studies met inclusion criteria for manuscript one. Emerging high-risk student characteristics include gender non-conforming (GNC) and non-binary, financial independence in college, and pregnant and …

Learning From 50 Years Of Aboriginal Alcohol Programs: A Summary, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

This publication is a summary of key messages from the book, Learning from 50 years of Aboriginal alcohol programs: beating the grog in Australia by Peter d’Abbs and Nicole Hewlett.

The book provides a comprehensive overview of the many actions taken over the last 50 years to prevent and reduce alcohol harms among Aboriginal people with a focus on actions led by Aboriginal communities. This summary of the book was developed by the HealthInfoNet Alcohol and other Drugs Knowledge Centre in collaboration with the authors, and aims to provide an accessible synthesis of the information and lessons learned as …

Estimating Cardiorespiratory Fitness In Older Adults Using The International Physical Activity Questionnaire, Kelsey R. Sewell, Jeremiah J. Peiffer, Shaun J. Markovic, Belinda M. Brown

Research outputs 2022 to 2026

Introduction:

Non-exercise estimates of cardiorespiratory fitness hold great utility for epidemiological research and clinical practice. Older adults may yield the greatest benefit from fitness estimates due to limited capacity to undergo strenuous maximal exercise testing, however, few of the previously developed non-exercise equations are suitable for use in older adults. Thus, the current study developed a non-exercise equation for estimating cardiorespiratory fitness in older adults derived from the widely used International Physical Activity Questionnaire (IPAQ).

Methods:

This study was a secondary analysis of baseline data from a randomized controlled trial. Participants were community-dwelling, cognitively unimpaired older adults aged 60–80 years …

Re-Living Trauma Near Death: An Integrative Review Using Grounded Theory Narrative Analysis, Nikki Johnston, Michael Chapman, Jo Gibson, Catherine Paterson, Murray Turner, Karen Strickland, Wai Man Liu, Christine Phillips, Kasia Bail

Research outputs 2022 to 2026

Background: Symptoms of emotional and physical stress near death may be related to previous experiences of trauma. Objective: To investigate current evidence regarding the following: (1) Is previous trauma identified in people who are dying, and if so, how? (2) How is previous trauma associated with the experience of death/dying in people with or without cognitive impairment? and (3) What palliative care interventions are available to people with previous trauma at the end of life? Design: This integrative review was conducted per Whittemore and Knafl’s guidelines, which involves a stepped approach, specifically (1) problem identification, (2) literature search, (3) data …

The European Association For Predictive, Preventive And Personalized Medicine (Epma) World Congress 2024: Pioneering The Intersection Of Tourism And Health Science, Fangli Hu, Jun Wen

Research outputs 2022 to 2026

No abstract provided.

Variations In The Germinal Center Response Revealed By Genetically Diverse Mouse Strains, Anne Marie Aubin, Daria Vdovenko, Roxanne Collin, Lois Balmer, Lise Coderre, Grant Morahan, Félix Lombard-Vadnais, Sylvie Lesage

Research outputs 2022 to 2026

The humoral response is complex and involves multiple cellular populations and signaling pathways. Bacterial and viral infections, as well as immunization regimens, can trigger this type of response, promoting the formation of microanatomical cellular structures called germinal centers (GCs). GCs formed in secondary lymphoid organs support the differentiation of high-affinity plasma cells and memory B cells. There is growing evidence that the quality of the humoral response is influenced by genetic variants. Using 12 genetically divergent mouse strains, we assessed the impact of genetics on GC cellular traits. At steady state, in the spleen, lymph nodes and Peyer's patches, we …