Medicine and Health Sciences Commons^™

The Effect Of The Primary Wound Closure Technique In The Surgical Treatment Of Closed Intra-Articular Calcaneal Fractures, Mohamed M. Abd El-Monem Gafar, Ashraf Hassen M. Mohammed, Ahmed A. Elseadawy, Mohamed Salah Labib

Journal of Medicine in Scientific Research

Aim: To assess the impact of the primary wound closure method in the surgical management of closed intra-articular calcaneal fractures, with the aim of improving postoperative wound healing, reducing complications, minimizing expenses, enhancing overall functional outcomes, and restoring foot function and patients' quality of life. Design: Our study, a prospective and retrospective cohort clinical study, was conducted in our hospitals. Patients and Methods: Twenty-eight patients with thirty-one intra-articular calcaneal fractures were enrolled, following stringent inclusion and exclusion criteria for patient selection. These patients underwent open reduction using an extensile lateral approach and internal fixation with plates and screws at our …

Clinical Study Of Combined Arthroscopic Drilling And Platelet Rich Plasma Injection In Knee Osteochondral Lesions In Middle-Aged Patients, Mohamed Salah Labib Mohamed, Mohamed Abd Elmoneam Gafar

Journal of Medicine in Scientific Research

Background: Osteochondral lesions commonly occur in the knee joints and causes detrimental effects on the quality of life. Arthroscopic drilling is the treatment option for mild to moderate lesions. However, it is debatable whether regenerated cartilage from arthroscopic drilling surgery is durable. It is speculated that induction of chondrocyte differentiation from subchondral mesenchymal stem cells is facilitated by platelet-rich plasma (PRP), which is a rich source of diverse growth factors.

Aim of work: To evaluate the procedures of combined arthroscopic drilling and PRP injection intra-articularly for mild to moderate knee osteochondral lesions management.

Patients and Methods: This randomized prospective study …

Short Term Effects Of Bariatric Surgeries On Renal And Hepatic Functions On Obese Morbid Patients, Naglaa F. Al-Mihy, Esayed Elmokadem, Atteyat Aboelmaged Semeya

Journal of Medicine in Scientific Research

Background: Bariatric surgery has emerged as a well-established treatment for achieving long-lasting and successful weight reduction. Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are currently the most frequently done operations. The aim of this research was to investigate the hepatic and renal alterations following bariatric procedures, with a particular focus on SG.

Methods: This observational prospective cohort research was performed on 100 morbidly obese individuals with BMI ≥40 kg/m² who underwent SG. All patients were evaluated before surgery clinically and all laboratory investigations were done before operation as baseline, 3 months, 6 months after surgery, and after one …

Telemedicine And Physical Visits: A Dynamic Duo In Obesity Management Among Adolescents, Egypt, Enas Sayed Abbas, Safaa Al Hussein Tawfik, Gehan Fouad Ahmad, Lamiaa Ibrahim Haroon, Taghreed K. M. Elhady, Amira Said Nassar

Journal of Medicine in Scientific Research

Childhood obesity, a serious global issue, leads to various health problems like diabetes, high blood pressure, high cholesterol, and psychological issues. In Egypt, inconsistent data shows a significant prevalence of obesity among adolescents, influenced by factors like gender, age, and lifestyle. The study aims to explore the effectiveness of telemedicine, in conjunction with physical visits, for managing obesity among adolescents in Egypt. Telemedicine, a cost-effective and engaging alternative to in-person visits, can help patients lose weight and provide a safe, remote alternative, expanding treatment access to hard-to-reach populations. The study is a controlled clinical trial on overweight or obese adolescents …

The Value Of Right Ventricular Systolic Function Assessment By 2d Speckle Tracking Echocardiography In Severe Ms, Alaa Ramadan Youssuf, Mohammad Morsy, Ibrahim Afifi, Mohamed Mansour, Eman H Seddik

Journal of Medicine in Scientific Research

Background: Many patients with long-standing mitral stenosis (MS) experience pulmonary hypertension (PH), which can eventually result in right heart failure. Several studies investigated the RV function changes in MS patients in the perioperative periods but focused on balloon mitral valvotomy (BMV). So our study aimed to assess the RV changes in severe MS patients planned for surgical mitral valve replacement (MVR).

Methods: A case-control study was carried out on severe MS patients planned for surgical MVR being unfit for BMV were subjected to conventional MS indices, RV Fractional area change (FAC), lateral tricuspid annular plane systolic excursion (TAPSE), RV global …

Mediastinal Packing For Massive Bleeding Following Acute Ascending Aortic Dissection Surgery: Outcomes And Risk Factors Analysis, Ahmed Shafeek Ali, Mostafa Abd Al Salam Mohamed Ghazi, Mahmoud Maher Abdou Ibrahim, Haitham Alshahat Ramadan

Journal of Medicine in Scientific Research

Background: Surgery for Acute Ascending Aortic Dissection (AAAD) is often complicated by severe perioperative coagulopathy and critical bleeding. Mediastinal packing is a widely recognised technique used to manage and control this complication. This retrospective study aims to analyze early outcomes and potential risk factors for patients subjected to mediastinal packing after AAAD surgery.

Methods: 352 consecutive patients who had undergone acute ascending aortic dissection (AAAD) surgery were studied at the National Heart Institution between February 2014 and Mars 2023. These patients were divided into two groups: the mediastinal packing with delayed closure group (n = 53; 15.05%) and …

Repair Vs. Replacement For Chronic Ischemic Mitral Valve Regurgitation: A Retrospective Cohort Study., Ahmed A Faragalla, Ahmed M Elshiemy, Sherif A Elhindawy, Ahmed A. Abedelhamid

Journal of Medicine in Scientific Research

Background: Chronic ischemic mitral regurgitation (CIMR) presents a surgical dilemma: repair or replace the mitral valve during coronary artery bypass grafting (CABG).

Aim of the work: This study investigates early outcomes following mitral valve repair versus replacement during CABG for CIMR patients.

Methods: The study employed a retrospective design, enrolling 100 patients who underwent CABG surgery with either mitral valve repair or replacement at the National Heart Institute. Patients were stratified into Group I (repair) and Group II (replacement). Further stratification within each group categorized patients by mitral regurgitation (MR) severity (moderately severe or severe).

Results: This analysis of mitral …

Adverse Pregnancy Outcomes Among Elderly Primigravida Women At Al-Galaa Maternity Teaching Hospital, Sherif M. Safwat, Marwa R. Shahin

Journal of Medicine in Scientific Research

Backgrounds: Pregnancy at advanced maternal age (AMA) is seen as a risk factor for poor maternal and perinatal outcomes. However, pregnancies with advanced maternal age have become more common in recent decades. This is attributable to increased employment options for women, a shift in gender norms, and improved reproductive medicine.

Objectives: Reviewing and assessment of the adverse pregnancy outcomes in elderly primigravida women compared to those with younger age.

Methodology: A case-control research study was conducted on patients who had attended for delivery at Al-Galaa Maternity Teaching Hospital during the period of one year from January 2022 to January 2023. …

One- Piece Foldable Intraocular Lens Versus 3- Piece Iol In Scleral Fixation Running Title, Ghada Samir Mohamed, Mohamed Gaber Abdallah

Journal of Medicine in Scientific Research

purpose.: To assess the stability of postoperative Intraocular Lens (IOL) between the one- piece foldable and three- piece IOLs by surgical technique of scleral fixation and so the efficacy of usage of one-piece IOL in this technique.

Material and method: This is a randomized controlled study includes one hundred eighteen eyes, which is divided into 2 groups. The group A includes fifty-nine eyes has implanted one- piece foldable IOL, while Group B with equal number of cases implanted three- piece foldable IOL. Cases were followed up for 12 months, every 3-month duration. Horizontal and vertical IOL optic tilt has been …

Abdominal Versus Vaginal Uterine Bisection For Retrieval Of Large Uteri During Laparoscopic Hysterectomy, Heba R. Elbasuiny, Ayman S. Dawood, Mohamed A. Raslan

Journal of Medicine in Scientific Research

Objective To assess the operative time, blood loss, and safety of two retrieval techniques in large uteri during total laparoscopic hysterectomy. Methods A cohort multicenter study conducted at Tanta University Hospitals and private laparoscopy centers in Delta region, Egypt, from June 2021 till October 2023. In this study, 73 patients were enrolled in this study and allocated into either abdominal bisection (Group I) or vaginal bisection (Group II). Abdominal bisection is performed by endoknife, while vaginal bisection is made by scalpel. Uterine size, hysterectomy time, uterine retrieval time, blood loss, and complications were recorded and compared. Results The mean age, …

Effect Of Yellow (577) Sub-Liminal Laser In Treatment Of Center Involved Macular Edema, Mohammed Shikhoun Ahmed, Eman Mohamed Etify, Tomas Nader Zakaria

Journal of Medicine in Scientific Research

Background: Advances in laser technology have led to the development of selective treatment without chorio-retinal damage. Subthreshold micropulse yellow laser has widespread benefits for the treatment of different macular disorders, as it allows the treatment of central macular edema without damage of photoreceptors or ganglion cell complex. Methods: Two hundred eyes of 120 patients with center involved mild to moderate macular edema attending at vitro-retinal unit/ ophthalmology department at Sohag Teaching Hospital were included. A pre-subliminal laser assessment of BCVA, CMT, and GCC was performed. Follow-up assessments were performed at one month, three months and six months post-laser treatment. Results: …

Conservative Approach Compared To Cesarean Hysterectomy In Mangement Of Placenta Accreta Spectrum At Tanta University Hospitals, Muhammad Abdelrahim Abdelgwaad, Ayman Shehata Dawod, Hesham Mohammad Elsaid Borg, Heba Rady Elbassiouny

Journal of Medicine in Scientific Research

Placenta accreta spectrum (PAS) poses a significant issue for obstetricians, primarily attributed to the rising incidence of pregnant women presented by this condition. This research aimed to evaluate management options of placenta accreta spectrum (PAS) at Tanta University Hospitals and to assess safety and efficacy of Shehata's procedure compared to cesarean hysterectomy. Patients & Methods: This observational study was carried out prospectively involving 70 pregnant women presented with PAS to the Emergency Room and Outpatient Clinic of the Obstetrics Department at Tanta University Hospitals, spanning from July 2023 to July 2024. Comprehensive demographic and surgical data were collected and documented. …

Inter-Reader Agreement And Accuracy Of O-Rads Mr Risk Stratification System In Assessment Of Adnexal Lesions, Mena Elerian Youssef Ekladious, Jehan Ibrahim M. Altohamy, Rania Hassan Mostafa Ahmed, Suzan Farouk Ibrahim Salib, Shrouk Mohamed Awadallah

Journal of Medicine in Scientific Research

Background Ultrasound is the initial modality employed to investigate adnexal lesions due to its high sensitivity and specificity in excluding malignancy when classic benign characteristics are observed. Nevertheless, the positive predictive value (PPV) of cancer can vary from 7% to 50% when a lesion has indeterminate imaging features in the US, and the PPV for cancer can range from 29% up to more than 50% when a lesion exhibits characteristics that are concerned for malignancy. (2). MRI has the capacity to enhance the PPV from cancer to 71%, with a negative predictive value of 98%. (3). The MRI's ability to …

Factors Affecting Non-Compliance With Treatment Among Diabetic Students At Sohag University, Rasha Gamal-El-Din Abu-El-Goud, Samah Wagdy Elkhayat, Ahmed Fathy Hamed, Seham Ahmed Abokresha

Journal of Medicine in Scientific Research

Background and objectives: Diabetes mellitus (DM) is a metabolic disease characterized by insufficient insulin synthesis, action, or both. Its prevalence is estimated to be alarmingly increasing. The aim of the study was studying factors influencing the non-compliance of diabetic students at Sohag University with treatment. Methods: Cross-sectional study at Sohag University for 7 months. Total number of diabetic students involved in the study was 153 students chosen from medical reports of administration of medical affairs in the university from May to November 2022; the participants who were studying in a scientific faculty were 51 (33.3%), and in Literary faculty were …

Running Shoes For Posterior Tibial Tendon Problems, Matthew Klein

Faculty Publications - College of Physical Therapy

Our perspective on stability and guidance are one of the many things that make Doctors of Running unique. I, Matt Klein, generally need at least mild stability in my footwear. Like many of our readers, I have continued to navigate and understand what a stability shoe is, what options there are out there, what actually provides stability/guidance and who stability actually works best for. Recent research has suggested that stability shoes tend to benefit those with a history of pronation-related injuries or who are unable to control the natural pronation motion during gait (Malisoux et al., 2016; Williems et al., …

ประสบการณ์การบริหารทรัพยากรสุขภาพของพยาบาลกลุ่มงานประกันสุขภาพโรงพยาบาลศูนย์, พชร พีระพัฒนพงษ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยเชิงคุณภาพเชิงพรรณนานี้ มีวัตถุประสงค์เพื่อบรรยายประสบการณ์การบริหารทรัพยากรสุขภาพของพยาบาลกลุ่มงานประกันสุขภาพ โรงพยาบาลศูนย์ ผู้ให้ข้อมูล คือ พยาบาลวิชาชีพที่ปฏิบัติงานบริหารทรัพยากรสุขภาพ ในกลุ่มงานประกันสุขภาพ โรงพยาบาลศูนย์ไม่น้อยกว่า 5 ปี ผ่านการอบรมหลักสูตรที่เกี่ยวข้องกับการบริหารทรัพยากรสุขภาพ และมีความยินดีในการเข้าร่วมการวิจัย จำนวนทั้งสิ้น 12 ราย เก็บรวบรวมข้อมูลโดยใช้วิธีการสัมภาษณ์เชิงลึก (In-dept interview) ร่วมกับการสังเกต (Observation) และการจดบันทึกภาคสนาม (Field notes) วิเคราะห์ข้อมูลแบบแก่นสาระตามวิธีการของ Braun and Clarke และตรวจสอบความน่าเชื่อถือของข้อมูลตามเกณฑ์ของ Guba and Lincoln ผลการวิเคราะห์ข้อมูลประสบการณ์การบริหารทรัพยากรสุขภาพของพยาบาลกลุ่มงานประกันสุขภาพ โรงพยาบาลศูนย์ ประกอบด้วย 5 ประเด็นหลัก และ 19 ประเด็นย่อย ดังต่อไปนี้ 1. การบริหารองค์ความรู้และศักยภาพบุคลากร ประกอบด้วย 4 ประเด็นย่อย ได้แก่ 1.1) การเรียนรู้และเข้าใจเกณฑ์กองทุนต่าง ๆ 1.2) การใช้ความรู้ความชำนาญด้านการพยาบาล 1.3) การพัฒนาทักษะการให้รหัสโรคและหัตถการ และ 1.4) การติดตามความรู้ด้านนโยบายและการเปลี่ยนแปลงระบบสุขภาพ 2. การทบทวนการใช้ทรัพยากรสุขภาพ ประกอบด้วย 3 ประเด็นย่อย ได้แก่ 2.1) การทบทวนความสมบูรณ์ของข้อมูลเพื่อการเบิกจ่าย 2.2) การทบทวนความสมเหตุสมผลของการใช้ทรัพยากร และ 2.3) การจัดทำรายงานและบันทึกผลการทบทวน 3. การบริหารงบประมาณและความคุ้มค่าของทรัพยากรสุขภาพ ประกอบด้วย 5 ประเด็นย่อย ได้แก่ 3.1) การวิเคราะห์ต้นทุนและผลตอบแทน 3.2) การควบคุมงบประมาณ 3.3) การบริหารมาตรฐานการดูแลผู้ป่วยให้สอดคล้องกับสิทธิ 3.4) การพัฒนากระบวนการให้เอื้อต่อการเบิกจ่าย และ 3.5) การสร้างนวัตกรรมหรือบริการใหม่ที่คุ้มค่า 4. การประสานงานเพื่อสร้างความร่วมมือใช้ทรัพยากรสุขภาพอย่างเหมาะสม ประกอบด้วย 3 ประเด็นย่อย ได้แก่ 4.1) การประสานงานภายในองค์กร 4.2) การประสานงานกับหน่วยงานภายนอก และ 4.3) การประสานงานกับผู้รับบริการ 5. …

Association Of Plasma Neurofilament Light Chain With Microstructural White Matter Changes In Down Syndrome, Herminia Diana Rosas, Nathaniel David Mercaldo, Yasemin Hasimoglu, Melissa Petersen, Lydia R. Lewis, Florence Lai, David Powell, Asim Dhungana, Ali Demir, David Keater, Michael Yassa, Adam M. Brickman, Sid O'Bryant

Neuroscience Faculty Publications

INTRODUCTION: Both micro- and macrostructural white matter (WM) abnormalities, particularly those related to axonal degeneration, are associated with cognitive decline in adults with Down syndrome (DS) prior to a diagnosis of Alzheimer disease. Neurofilament light chain (NfL) is a support protein within myelinated axons released into blood following axonal damage. In this study we investigated cross-sectional relationships between WM microstructural changes as measured by diffusion tensor imaging (DTI) and plasma NfL concentration in adults with DS without dementia.

METHODS: Thirty cognitively stable (CS) adults with DS underwent diffusion-weighted MRI scanning and plasma NfL measurement. DTI measures of select WM tracts …

Get It In Writing: How To Make Medications For Opioid Use Disorder Available During Incarceration, Margaret J. Mcgladrey, Jordan Kelsch, Michelle R. Lofwall, Laura C. Fanucchi, Sharon L. Walsh, Carrie B. Oser

Center on Drug and Alcohol Research Faculty Publications

In a case example from the Kentucky HEALing Communities Study, extensive resources were deployed to address structural barriers and facilitate the provision of medication for opioid use disorder (OUD) in an urban county jail. However, implementation was unsuccessful, and this case example emphasizes the importance of including evidence-based medication for OUD (MOUD) treatment in the scope of work of jails’ contracted medical providers. The privatization of correctional health care services allows local governments with opioid abatement funds to incorporate requirements into medical provider contracts to screen all people entering jails for OUD and to offer MOUD at intake, throughout incarceration, …

The Development Of A Recovery Coaching Training Curriculum To Facilitate Linkage To And Increase Retention On Medications For Opioid Use Disorder, Trevor Moffitt, Amanda Fallin-Bennett, Laura Fanucchi, Sharon L. Walsh, Christopher Cook, Devin Oller, Anna Ross, Molly Gallivan, John Lauckner, Jeremy Byard, Phoebe Wheeler-Crum, Michelle R. Lofwall

Center on Drug and Alcohol Research Faculty Publications

Introduction: Medication treatment for opioid use disorder (MOUD) decreases opioid overdose risk and is the standard of care for persons with opioid use disorder (OUD). Recovery coach (RC)-led programs and associated training curriculums to improve outcomes around MOUD are limited. We describe our comprehensive training curriculum including instruction and pedagogy for novel RC-led MOUD linkage and retention programs and report on its feasibility.

Methods–pedagogy and training development: The Kentucky HEALing (Helping to End Addiction Long-termSM) Communities Study (HCS) created the Linkage and Retention RC Programs with a local recovery community organization, Voices of Hope-Lexington. RCs worked to reduce participant barriers …

A Brief Report On Juvenile Amyotrophic Lateral Sclerosis Cases In The United States National Als Registry: 2010– 2018, Jaime Raymond, Jasmine Berry, Edward J. Kasarskis, Theodore Larson, D. Kevin Horton, Paul Mehta

Neurology Faculty Publications

Juvenile ALS (jALS) is a rare form of ALS, defined as symptom onset before age 25. This report describes the demographic characteristics of confirmed and likely jALS cases in a large cohort of ALS patients ascertained in the National ALS Registry (Registry) from 2010 to 2018. Patients in the Registry must be at least 18 years of age. Of the 44 identified patients, 37.8% were diagnosed at age 24, were more likely to be nonwhite (54.5%), male (79.5%), and live in the Midwest or Northeast regions (54.5%) of the US. Some 68.9% of the jALS cases were received from federal …

The Differential Proteomic Response To Ischemic Stroke In Appalachian Subjects Treated With Mechanical Thrombectomy, Christopher J. Mclouth, Benton Maglinger, Jacqueline A. Frank, Kristin J. Hazelwood, Jordan P. Harp, Will Cranford, Shivani Pahwa, David Dornbos Iii, Amanda L. Trout, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker

Neurology Faculty Publications

Introduction The Appalachia region of North America is known to have significant health disparities, specifically, worse risk factors and outcomes for stroke. Appalachians are more likely to have comorbidities related to stroke, such as diabetes, obesity, and tobacco use, and are often less likely to have stroke interventions, such as mechanical thrombectomy (MT), for emergent large vessel occlusion (ELVO). As our Comprehensive Stroke Center directly serves stroke subjects from both Appalachian and non-Appalachian areas, inflammatory proteomic biomarkers were identified associated with stroke outcomes specific to subjects residing in Appalachia. Methods There were 81 subjects that met inclusion criteria for this …

Perceived Versus Actual Hiv Risk Among Prep Indicated Persons With Criminal Legal Involvement, Taylor Krajewski, Katherine H. Lemasters, Carrie B. Oser, Lauren Brinkley-Rubinstein

Behavioral Science Faculty Publications

Individuals involved with community supervision experience multi-level obstacles impacting health outcomes. This is a high-risk period for HIV acquisition due to potential reengagement in unprotected sex and/or unsafe injection drug practices. This study aimed to assess the congruence between actual and perceived HIV risk and the degree to which individual, social, and behavioral factors impact risk perception among individuals on community supervision. While all participants were clinically indicated for PrEP, most participants (81.5%) did not consider themselves at risk for HIV (69.5%) or were not sure of their risk (12.0%). Among those with no or unsure perceived risk, 94% engaged …

Screening Incarcerated Women For Opioid Use Disorder, Michele Staton, Martha Tillson, Mary M. Levi, Matthew Webster, Carrie B. Oser, Carl Leukefeld

Behavioral Science Faculty Publications

The overall aim of the present study is to examine the utility of the DSM OUD Checklist and the NM-ASSIST screening tools to identify symptoms consistent with OUD among incarcerated women in county jails. This study contributes to the existing literature because research on screening and assessment approaches for incarcerated women has been limited. The focus of the current study is to describe the screening procedures and study recruitment for a larger parent study focused on increasing treatment linkages. Study findings indicate a positive correlation between indicators of OUD using the two screening tools, as well as a high degree …

Trends In Youth Opinions About Police Agencies In The United States, 2017–2021, Delvon T. Mattingly, Nancy L. Fleischer

Behavioral Science Faculty Publications

Introduction: As civil unrest about policing in the United States (US) continue, research on changing opinions about police agencies is needed, especially among younger populations. These opinions may be associated with distress and other health outcomes that come with public health implications.

Methods: We aggregated and used yearly 2017 to 2021 data on 12th-grade youth living in the US from the Monitoring the Future cross-sectional study (n = 7132). We categorized opinions about police agency job per- formance into 1) very poor/poor (hereafter: poor), 2) fair/good/very good, and 3) no opinion. To examine trends in policy agency opinions over time, …

A Social History Of Opioids’ Crimedical Cycle, Jerel M. Ezell, Alex Rains, Babatunde Patrick Ajayi, Kyle Miller, Erin Augustine, Dawn Goddard-Eckrich, Elizabeth N. Kinnard, Michelle R. Lofwall

Behavioral Science Faculty Publications

Historically, public and political discourse around people who nonmedically use opioids has largely been rendered via a deficits-oriented lens, presenting this population as weak, disinterested, and deviant,and thus undesirable and ill-positioned for wellness and communal integration. These narratives, and subsequent policies used to engage people who use opioids, are intermittently formed and disrupted by geopolitical changes, as public and institutional attitudes, often driven by racial and class-related considerations, shift. As part of what we term the crimedical cycle, a population’s behaviors fluctuate between periods of medicalization and criminalization. Strengths-based theory, an offshoot of ‘positive psychology’ that helps contextualize the crimedical …

Extended-Release Injection Vs Sublingual Buprenorphine For Opioid Use Disorder With Fentanyl Use, Edward V. Nunes, Sandra D. Comer, Michelle R. Lofwall, Sharon L. Walsh, Stefan Peterson, Fredrik Tiberg, Peter Hjelmstrom, Natalie R. Budilovsky-Kelley

Behavioral Science Faculty Publications

Importance: Fentanyl has exacerbated the opioid use disorder (OUD) and opioid overdose epidemic. Data on the effectiveness of medications for OUD among patients using fentanyl are limited.

Objective: To assess the effectiveness of sublingual or extended-release injection formulations of buprenorphine for the treatment of OUD among patients with and without fentanyl use.

Design, Setting, and Participants: Post hoc analysis of a 24-week, randomized, double-blind clinical trial conducted at 35 outpatient sites in the US from December 2015 to November 2016 of sublingual buprenorphine-naloxone vs extended-release subcutaneous injection buprenorphine (CAM2038) for patients with OUD subgrouped by presence vs absence of fentanyl …

Adgrl1 Is A Glucose Receptor Involved In Mediating Energy And Glucose Homeostasis, Kavaljit H Chhabra, Siresha Bathina, Tumininu S Faniyan, Dennis J Samuel, Muhammad Ummear Raza, Leticia Maria De Souza Cordeiro, Gonzalo Viana Di Prisco, Brady K Atwood, Jorge Robles, Lauren Bainbridge, Autumn Davis

Pharmacology and Nutritional Sciences Faculty Publications

AIMS/HYPOTHESIS: The brain is a major consumer of glucose as an energy source and regulates systemic glucose as well as energy balance. Although glucose transporters such as GLUT2 and sodium-glucose cotransporter 2 (SGLT2) are known to regulate glucose homeostasis and metabolism, the identity of a receptor that binds glucose to activate glucose signalling pathways in the brain is unknown. In this study, we aimed to discover a glucose receptor in the mouse hypothalamus.

METHODS: Here we used a high molecular mass glucose-biotin polymer to enrich glucose-bound mouse hypothalamic neurons through cell-based affinity chromatography. We then subjected the enriched neurons to …

Rare Variant Analyses Validate Known Als Genes In A Multi-Ethnic Population And Identifies Antxr2 As A Candidate In Pls, Tess D. Pottinger, Joshua E. Motelow, Gundula Povysil, Cristiane A. Martins Moreno, Zhong Ren, Hemali Phatnani, The New York Genome Center Als Sequencing Consortium, Timothy J. Aitman, Javier Santoyo‑Lopez, Scottish Genomes Partnership, Hiroshi Mitsumoto, Als Cosmos Study Group, Pls Cosmos Study Group, Gtac Investigators, David B. Goldstein, Matthew B. Harms

Neurology Faculty Publications

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting over 300,000 people world‑ wide. It is characterized by the progressive decline of the nervous system that leads to the weakening of muscles which impacts physical function. Approximately, 15% of individuals diagnosed with ALS have a known genetic variant that contributes to their disease. As therapies that slow or prevent symptoms continue to develop, such as antisense oligonucleotides, it is important to discover novel genes that could be targets for treatment. Additionally, as cohorts continue to grow, performing analyses in ALS subtypes, such as primary lateral sclerosis (PLS), becomes possible …

Abnormalities In Pharyngeal Arch-Derived Structures In Satb2-Associated Syndrome, Yuri A. Zarate, Katherine Bosanko, Nada Derar, Jennifer L. Fish

Pediatrics Faculty Publications

SATB2-associated syndrome (SAS, glass syndrome, OMIM#612313) is a neurodevelopmental autosomal dominant disorder with frequent craniofacial abnormalities including palatal and dental anomalies. To assess the role of Satb2 in craniofacial development, we analyzed mutant mice at different stages of development. Here, we show that Satb2 is broadly expressed in early embryonic mouse development including the mesenchyme of the second and third arches. Satb2-/- mutant mice exhibit microglossia, a shortened lower jaw, smaller trigeminal ganglia, and larger thyroids. We correlate these findings with the detailed clinical phenotype of four individuals with SAS and remarkable craniofacial phenotypes with one requiring mandibular distraction in …

Correction: Bayesian Kinetic Modeling For Tracer-Based Metabolomic Data, Xu Zhang, Ya Su, Andrew N. Lane, Arnold Stromberg, Teresa Whei-Mei Fan, Chi Wang

Statistics Faculty Publications

No abstract provided.